Ropeginterferon alfa-2b

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Ropeginterferon alfa-2b
Accession Number
DB15119
Type
Biotech
Groups
Investigational
Description

Ropeginterferon alfa-2b is under investigation in clinical trial NCT01949805 (Pegylated Interferon Alpha-2b Versus Hydroxyurea in Polycythemia Vera).

Synonyms
Not Available
External IDs
AOP2014
Categories
UNII
981TME683S
CAS number
1335098-50-4

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be decreased when combined with Ropeginterferon alfa-2b.
3-isobutyl-1-methyl-7H-xanthineThe metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Ropeginterferon alfa-2b.
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Ropeginterferon alfa-2b.
7-DeazaguanineThe metabolism of 7-Deazaguanine can be decreased when combined with Ropeginterferon alfa-2b.
7,9-DimethylguanineThe metabolism of 7,9-Dimethylguanine can be decreased when combined with Ropeginterferon alfa-2b.
8-azaguanineThe metabolism of 8-azaguanine can be decreased when combined with Ropeginterferon alfa-2b.
8-chlorotheophyllineThe metabolism of 8-chlorotheophylline can be decreased when combined with Ropeginterferon alfa-2b.
9-DeazaguanineThe metabolism of 9-Deazaguanine can be decreased when combined with Ropeginterferon alfa-2b.
9-MethylguanineThe metabolism of 9-Methylguanine can be decreased when combined with Ropeginterferon alfa-2b.
AcefyllineThe metabolism of Acefylline can be decreased when combined with Ropeginterferon alfa-2b.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
Not Available
ATC Codes
L03AB15 — Ropeginterferon alfa-2b

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1RecruitingTreatmentHealthy Volunteers1
2RecruitingPreventionChronic Myeloid Leukemia in Remission1
2RecruitingTreatmentPolycythemia Vera (PV)1
2RecruitingTreatmentPrimary Myelofibrosis / Secondary Myelofibrosis1
3Active Not RecruitingOtherPolycythemia Vera (PV)1
3CompletedTreatmentPolycythemia Vera (PV)2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Delaporte E, Renton KW: Cytochrome P4501A1 and cytochrome P4501A2 are downregulated at both transcriptional and post-transcriptional levels by conditions resulting in interferon-alpha/beta induction. Life Sci. 1997;60(10):787-96. doi: 10.1016/s0024-3205(97)00006-4. [PubMed:9064483]

Drug created on May 20, 2019 08:51 / Updated on September 02, 2019 20:27