Displaying drugs 3576 - 3600 of 11741 in total
Sufentanil
Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes.
Also known as Dsuvia, the sublingual form is used for the management of acute pain in adults that...
Approved
Investigational
Matched Description: … Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a ... This route of administration is intended to be a simple, effective, non-invasive analgesic option to …
Tenapanor
Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). It was first designed and synthesized in 2012. As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and currently only medication within its class[A185489,A185492,A185495] and...
Approved
Investigational
Matched Description: … first and currently only medication within its class[A185489,A185492,A185495] and therefore exists as a ... Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant …
Umbralisib
Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with rituximab (an anti-CD20 drug), either alone or in combination with chemotherapy. Unfortunately, many patients experience a relapse or develop resistance to these drugs. Treatment options then become limited, and alternate treatments for the lymphoma are...
Approved
Investigational
Withdrawn
Matched Description: … Unfortunately, many patients experience a relapse or develop resistance to these drugs. ... Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with ... On February 5, 2021, the Food and Drug Administration granted accelerated approval to umbralisib, a …
Tocainide
An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels.
Approved
Matched Description: … An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels. …
Oxtriphylline
Oxtriphylline is the choline salt form of theophylline. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all...
Approved
Matched Description: … Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor …
Ciprocinonide
Approved
Investigational
Mecasermin
Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1)[FDA Label]. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is...
Approved
Investigational
Matched Description: … IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a …
Daratumumab
Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for...
Approved
Matched Description: … [A7935] It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ …
Famotidine
Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H2 receptor antagonists, famotidine displays high selectivity towards...
Approved
Matched Description: … Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric ... H2 receptor antagonists, famotidine displays high selectivity towards this receptor; in a ... inhibiting gastric acid secretion than [cimetidine] and eight times more potent than [ranitidine] on a …
Pimavanserin
Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT2A and HT2C receptors. Unlike other atypical antipsychotics, pimavanserin lacks inherent dopaminergic activity. In fact, pimavanserin is the...
Approved
Investigational
Matched Description: … [L48241,A232573] Pimavanserin was also under review as a potential treatment for dementia-related psychosis ... hallucinations and delusions associated with Parkinson's disease psychosis thanks to favorable results from a …
Oxaprozin
Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
Approved
Matched Description: … Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation …
Amaranthus spinosus pollen
Amaranthus spinosus pollen is the pollen of the Amaranthus spinosus plant. Amaranthus spinosus pollen is mainly used in allergenic testing.
Approved
Orthosiphon aristatus leaf
Approved
Experimental
Pegvaliase
Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from Anabaena variabilis that converts phenylalanine to ammonia and trans-cinnamic acid . Both the U.S. Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the treatment of adult patients with phenylketonuria (PKU). Phenylketonuria is a...
Approved
Investigational
Matched Description: … The presence of a PEG moiety in pegvaliase-pqpz allows a reduced immune response and improved pharmacodynamic ... Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis ... Phenylketonuria is a rare autosomal recessive disorder that is characterized by deficiency of the enzyme …
Sotorasib
Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer. This mutation makes up >50% of all KRAS mutations. Mutant KRAS discovered in 1982 but was not considered a druggable...
Approved
Investigational
Matched Description: … [A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s …
Salmon calcitonin
Synthetic peptide, 32 residues long formulated as a nasal spray.
Approved
Investigational
Matched Description: … Synthetic peptide, 32 residues long formulated as a nasal spray. …
Triamterene
Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on...
Approved
Matched Description: … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. ... Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management ... [A177985] Since it acts on the distal nephron where only a small fraction of sodium ion reabsorption …
Decitabine
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia. Further mutations leading to increased proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a poor prognosis.[A215082, A215092] Among treatment options, nucleoside analogues such as...
Approved
Investigational
Matched Description: … Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying ... proliferation of cancerous cells can eventually lead to secondary acute myeloid leukemia, which has a …
Betazole
A histamine H2 agonist used clinically to test gastric secretory function.
Approved
Matched Description: … A histamine H2 agonist used clinically to test gastric secretory function. …
Gemifloxacin
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are...
Approved
Investigational
Matched Description: … Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment …
Streptococcus pneumoniae type 6a capsular polysaccharide antigen
Approved
Experimental
Etafedrine
Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined with other drugs in the brand names Nethaprin and Dalmacol . It was previously available as both the free base and as the hydrochloride salt manufactured by Sanofi-Aventis (now Sanofi) has been discontinued .
Ethylephedrine is...
Approved
Matched Description: … Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined ... The hydrochloride is be prepared by passing hydrogen chloride through a solution of ethylephedrine in …
Bird pepper
Bird pepper is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Bird pepper is a plant/plant extract used in some OTC (over-the-counter) products. …
Anisotropine methylbromide
Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary...
Approved
Matched Description: … Anisotropine methylbromide is a quaternary ammonium compound. ... activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a …
Displaying drugs 3576 - 3600 of 11741 in total