Famotidine - DrugBank

ID Pharmacology Interactions References Trials Economics Properties Spectra Taxonomy

Targets (1)Enzymes (1)Transporters (2)

Targets (1)Enzymes (1)Transporters (2)Biointeractions (5)

Identification

Name

Famotidine

Accession Number

DB00927 (APRD00296)

Type

Small Molecule

Groups

Approved

Description

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. [PubChem]

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

(1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide

3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide

3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine

Famotidina

Famotidinum

N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide

External IDs

L 643341 / MK-208 / YM-11170

Product Ingredients

Not Available

Product Images

Approved Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Bci Famotidine	Tablet	40 mg	Oral	Baker Cummins Inc	Not applicable	Not applicable	Canada
Bci Famotidine	Tablet	20 mg	Oral	Baker Cummins Inc	Not applicable	Not applicable	Canada
Famotidine	Powder, for suspension	40 mg/5mL	Oral	Paddock Laboratories, Inc.	2010-05-28	Not applicable	US
Famotidine 10mg	Tablet	10 mg	Oral	Laboratoire Riva Inc	Not applicable	Not applicable	Canada
Famotidine Injection	Solution	10 mg	Intravenous	Mylan Pharmaceuticals	Not applicable	Not applicable	Canada
Famotidine Injection	Solution	10 mg	Intravenous	Hospira, Inc.	Not applicable	Not applicable	Canada
Famotidine Injection	Solution	10 mg	Intravenous	Fresenius Kabi	Not applicable	Not applicable	Canada
Famotidine Injection	Solution	10 mg	Intravenous	Mylan Pharmaceuticals	Not applicable	Not applicable	Canada
Famotidine IV Injection	Solution	10 mg	Intravenous	Teva	Not applicable	Not applicable	Canada
Famotidine IV Injection	Solution	10 mg	Intravenous	Teva	Not applicable	Not applicable	Canada
Famotidine Omega -(with Preservative,benzyl Alcohol)	Solution	10 mg	Intravenous	Omega Laboratories Ltd	2003-10-31	Not applicable	Canada
Famotidine Omega -(without Preservative)	Solution	10 mg	Intravenous	Omega Laboratories Ltd	2003-10-30	Not applicable	Canada
Famotidine Tablets	Tablet	40 mg	Oral	Sanis Health Inc	2010-06-15	Not applicable	Canada
Famotidine Tablets	Tablet	20 mg	Oral	Sanis Health Inc	2010-06-15	Not applicable	Canada
Famotidine Tablets	Tablet	40 mg	Oral	Ivax Pharmaceuticals Incorporated	Not applicable	Not applicable	Canada
Famotidine Tablets	Tablet	20 mg	Oral	Ivax Pharmaceuticals Incorporated	Not applicable	Not applicable	Canada
Famotidine-20	Tablet	20 mg	Oral	Pro Doc Limitee	2000-05-23	2010-07-13	Canada
Famotidine-40	Tablet	40 mg	Oral	Pro Doc Limitee	2000-05-23	2010-07-13	Canada
Mylan-famotidine	Tablet	40 mg	Oral	Mylan Pharmaceuticals	1995-12-31	Not applicable	Canada
Mylan-famotidine	Tablet	20 mg	Oral	Mylan Pharmaceuticals	1995-12-31	Not applicable	Canada
Ntp-famotidine	Tablet	40 mg	Oral	Teva	Not applicable	Not applicable	Canada
Ntp-famotidine	Tablet	20 mg	Oral	Teva	Not applicable	Not applicable	Canada
Nu-famotidine Tab 20mg	Tablet	20 mg	Oral	Nu Pharm Inc	1994-12-31	2012-09-04	Canada
Nu-famotidine Tab 40mg	Tablet	40 mg	Oral	Nu Pharm Inc	1994-12-31	2012-09-04	Canada
Penta-famotidine	Tablet	40 mg	Oral	Pentapharm Ltd.	Not applicable	Not applicable	Canada
Penta-famotidine	Tablet	20 mg	Oral	Pentapharm Ltd.	Not applicable	Not applicable	Canada
Pepcid	Tablet, film coated	20 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	1986-10-15	2016-12-23	US
Pepcid	Tablet, film coated	20 mg/1	Oral	Marathon Pharmaceuticals	1986-10-15	2016-10-13	US
Pepcid	Powder, for suspension	40 mg/5mL	Oral	Salix Pharmaceuticals	1987-06-01	Not applicable	US
Pepcid	Tablet, film coated	40 mg/1	Oral	Marathon Pharmaceuticals	1986-10-15	2016-10-13	US
Pepcid I.V. 10mg/ml	Solution	10 mg	Intravenous	Merck Ltd.	1987-12-31	2006-11-10	Canada
Pepcid Tab 20mg	Tablet	20 mg	Oral	Merck Ltd.	1986-12-31	2013-07-15	Canada
Pepcid Tab 40mg	Tablet	40 mg	Oral	Merck Ltd.	1986-12-31	2013-07-15	Canada
Ratio-famotidine 20mg	Tablet	20 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	2000-07-11	2006-08-04	Canada
Ratio-famotidine 40mg	Tablet	40 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	2000-07-11	2006-08-04	Canada
Rhoxal-famotidine	Tablet	40 mg	Oral	Rhoxalpharma Inc	1999-08-03	2004-08-02	Canada
Rhoxal-famotidine	Tablet	20 mg	Oral	Rhoxalpharma Inc	1999-08-03	2004-08-02	Canada
Riva-famotidine 20 mg	Tablet	20 mg	Oral	Laboratoire Riva Inc	2000-05-15	2003-07-28	Canada
Riva-famotidine 40 mg	Tablet	40 mg	Oral	Laboratoire Riva Inc	2000-05-15	2003-07-28	Canada
Teva-famotidine	Tablet	40 mg	Oral	Teva	1993-12-31	Not applicable	Canada
Teva-famotidine	Tablet	20 mg	Oral	Teva	1993-12-31	Not applicable	Canada
Ulcidine	Tablet	20 mg	Oral	Valeant Canada Lp Valeant Canada S.E.C.	1998-03-24	2014-07-30	Canada
Ulcidine	Tablet	40 mg	Oral	Valeant Canada Lp Valeant Canada S.E.C.	1998-03-24	2014-07-30	Canada

Approved Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Apo-famotidine Injectable	Solution	10 mg	Intravenous	Apotex Corporation	2004-05-27	2013-08-02	Canada
Apo-famotidine Injectable	Solution	10 mg	Intravenous	Apotex Corporation	2003-11-17	2013-08-02	Canada
Apo-famotidine Tab 20mg USP	Tablet	20 mg	Oral	Apotex Corporation	1993-12-31	Not applicable	Canada
Apo-famotidine Tab 40mg USP	Tablet	40 mg	Oral	Apotex Corporation	1993-12-31	Not applicable	Canada
Famotidine	Tablet, film coated	20 mg/1	Oral	Cardinal Health	2009-06-10	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Aidarex Pharmaceuticals LLC	2001-04-16	Not applicable	US
Famotidine	Injection, solution	10 mg/mL	Intravenous	Fresenius Kabi	2001-03-15	Not applicable	US
Famotidine	Injection	10 mg/mL	Intravenous	Mylan Institutional	2008-06-26	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2001-04-16	2017-03-08	US
Famotidine	Injection, solution	10 mg/mL	Intravenous	Pfizer Laboratories Div Pfizer Inc.	2011-05-10	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	A S Medication Solutions	2001-04-16	2017-06-20	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2012-07-27	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Golden State Medical Supply	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Mylan Institutional	2001-05-01	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Clinical Solutions Wholsesale	2017-07-06	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Major	2009-06-10	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Wockhardt	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2010-04-30	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2015-12-22	Not applicable	US
Famotidine	Powder, for suspension	40 mg/5mL	Oral	Lupin Pharmaceuticals	2010-06-29	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2001-04-16	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Unit Dose Services	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Remedy Repack	2013-03-05	2016-11-30	US
Famotidine	Tablet	20 mg/1	Oral	Unit Dose Services	2016-01-29	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Proficient Rx LP	2016-01-29	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Clinical Solutions Wholsesale	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Cardinal Health	2010-10-13	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Remedy Repack	2013-07-01	2017-01-04	US
Famotidine	Tablet	20 mg/1	Oral	Blue Point Laboratories	2014-04-07	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Apotheca, Inc.	2001-04-16	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	St. Marys Medical Park Pharmacy	2013-07-10	Not applicable	US
Famotidine	Injection	10 mg/mL	Intravenous	West Ward Pharmaceutical	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Aurobindo Pharma	2015-12-22	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2016-01-29	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Mc Kesson Contract Packaging	2011-10-25	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Golden State Medical Supply	2001-04-16	2017-06-20	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Teva	2001-04-16	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Av Pak	2014-10-06	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Nu Care Pharmaceutical, Inc.	2016-01-29	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Cardinal Health	2010-05-07	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Av Kare, Inc.	2015-11-16	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2009-07-01	2017-01-05	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Carilion Materials Management	2001-04-16	Not applicable	US
Famotidine	Powder, for solution	40 mg/5mL	Oral	Hi Tech Pharmacal Co., Inc.	2016-03-16	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	A S Medication Solutions	2001-04-16	2017-06-20	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Kaiser Foundations Hospitals	2005-02-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Mylan Pharmaceuticals	2001-04-16	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Unit Dose Services	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2013-12-30	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Mesource Pharmaceuticals	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Legacy Pharmaceutical Packaging	2009-10-26	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Dr Reddy's Laboratories	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2001-04-16	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	North Star Rx Llc	2009-07-01	2016-10-13	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2014-09-30	2017-02-04	US
Famotidine	Injection	10 mg/mL	Intravenous	Mylan Institutional	2008-06-26	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Remedy Repack	2014-10-30	2017-04-27	US
Famotidine	Tablet	20 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2016-01-29	Not applicable	US
Famotidine	Powder, for suspension	40 mg/5mL	Oral	Zydus Pharmaceuticals Usa, Inc.	2010-05-27	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2001-04-16	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Remedy Repack	2015-03-20	2017-04-14	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Remedy Repack	2013-03-05	2016-11-30	US
Famotidine	Tablet	20 mg/1	Oral	Unit Dose Services	2016-01-29	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Cardinal Health	2013-07-05	Not applicable	US
Famotidine	For suspension	40 mg/5mL	Oral	Novel Laboratories, Inc.	2012-12-17	Not applicable	US
Famotidine	Tablet	10 mg/1	Oral	bryant ranch prepack	2010-02-18	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Amerincan Health Packaging	2007-03-20	2016-01-31	US
Famotidine	Tablet	20 mg/1	Oral	Alembic Pharmaceuticals Limited	2016-01-29	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2001-04-16	Not applicable	US
Famotidine	Injection, solution	10 mg/mL	Intravenous	Pfizer Laboratories Div Pfizer Inc.	2011-05-10	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Cardinal Health	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Lake Erie Medical Dba Quality Care Produts Llc	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2015-03-23	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Northwind Pharmaceuticals	2014-08-25	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	bryant ranch prepack	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Major	2009-06-10	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Wockhardt	2001-04-16	Not applicable	US
Famotidine	Injection	10 mg/mL	Intravenous	West Ward Pharmaceutical	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Wockhardt	2001-04-16	Not applicable	US
Famotidine	Injection, solution	20 mg/50mL	Intravenous	Baxter Laboratories	2001-05-10	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2016-05-31	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Alembic Pharmaceuticals Limited	2016-01-29	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2011-02-11	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2017-04-25	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Physicians Total Care, Inc.	2007-07-10	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Blue Point Laboratories	2014-04-07	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Stat Rx USA	2001-04-16	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Carlsbad Technology, Inc.	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Aurobindo Pharma	2015-12-22	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Unit Dose Services	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Ncs Health Care Of Ky, Inc Dba Vangard Labs	2010-04-30	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Directrx	2014-01-01	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2012-07-27	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2013-03-05	2016-11-08	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Legacy Pharmaceutical Packaging	2009-10-26	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Dr Reddy's Laboratories	2001-04-16	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2015-08-26	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Aidarex Pharmaceuticals LLC	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2015-06-16	2017-06-20	US
Famotidine	Injection	10 mg/mL	Intravenous	Mylan Institutional	2008-06-26	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Northwind Pharmaceuticals	2014-12-29	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	bryant ranch prepack	2001-04-16	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Blenheim Pharmacal, Inc.	2015-03-25	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	St. Marys Medical Park Pharmacy	2014-04-21	Not applicable	US
Famotidine	Injection	10 mg/mL	Intravenous	West Ward Pharmaceutical	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Wockhardt	2001-04-16	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Preferreed Pharmaceuticals Inc.	2016-12-22	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Avera Mc Kennan Hospital	2015-03-01	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	A S Medication Solutions	2001-04-16	2017-06-20	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Teva	2001-04-16	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Av Pak	2014-10-06	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Red Pharm Drug, Inc.	2016-01-29	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Cardinal Health	2010-09-01	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Av Kare, Inc.	2013-09-18	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Mc Kesson Packaging Services A Buisness Unit Of Mc Kesson Corporation	2007-06-12	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Carilion Materials Management	2001-04-16	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Alembic Pharmaceuticals Limited	2016-01-29	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2001-04-16	Not applicable	US
Famotidine	Injection, solution	10 mg/mL	Intravenous	Pfizer Laboratories Div Pfizer Inc.	2011-05-10	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Proficient Rx LP	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Remedy Repack	2017-01-20	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Nucare Pharmaceuticals, Inc.	2016-01-29	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Mylan Pharmaceuticals	2001-04-16	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Unit Dose Services	2016-01-29	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Alembic Pharmaceuticals Limited	2016-01-29	Not applicable	US
Famotidine	For suspension	40 mg/5mL	Oral	Gavis Pharmaceuticals, LLC.	2012-12-17	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Remedy Repack	2017-04-25	Not applicable	US
Famotidine	Tablet, film coated	40 mg/1	Oral	Physicians Total Care, Inc.	2002-11-15	Not applicable	US
Famotidine	Injection, solution	10 mg/mL	Intravenous	Fresenius Kabi	2001-07-19	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	North Star Rx Llc	2009-07-01	2016-10-13	US
Famotidine	Tablet	40 mg/1	Oral	Carlsbad Technology, Inc.	2001-04-16	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	Dispensing Solutions, Inc.	2001-04-16	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Pd Rx Pharmaceuticals, Inc.	2011-02-11	Not applicable	US
Pepcid	Tablet, film coated	40 mg/1	Oral	Valeant Pharmaceuticals North America	2001-04-16	Not applicable	US
Pepcid	Tablet, film coated	20 mg/1	Oral	Marathon Pharmaceuticals	2001-04-16	Not applicable	US
Pepcid	Tablet, film coated	40 mg/1	Oral	Marathon Pharmaceuticals	2014-05-27	Not applicable	US
Pepcid	Tablet, film coated	40 mg/1	Oral	Marathon Pharmaceuticals	2001-04-16	Not applicable	US
Pepcid	Tablet, film coated	20 mg/1	Oral	Valeant Pharmaceuticals North America	2001-04-16	Not applicable	US
Pepcid	Tablet, film coated	20 mg/1	Oral	Marathon Pharmaceuticals	2014-05-27	Not applicable	US

Approved Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
7 Select Acid Controller	Tablet	20 mg/1	Oral	7 Eleven	2014-08-05	Not applicable	US
Acid Control	Tablet	10 mg	Oral	Teva	1997-06-17	Not applicable	Canada
Acid Control	Tablet	20 mg	Oral	Apotex Corporation	2014-04-28	Not applicable	Canada
Acid Control	Tablet	10 mg	Oral	Vita Health Products Inc	1998-10-27	Not applicable	Canada
Acid Control	Tablet	10 mg	Oral	Apotex Corporation	2000-07-11	Not applicable	Canada
Acid Control	Tablet	10 mg	Oral	Pendopharm Division Of De Pharmascience Inc	1997-09-08	2015-01-19	Canada
Acid Control Original Strength	Tablet	10 mg/1	Oral	Medicine Shoppe International	2009-10-19	Not applicable	US
Acid Controller	Tablet	20 mg/1	Oral	H.E.B.	2016-09-14	Not applicable	US
Acid Controller	Tablet	20 mg/1	Oral	International Laboratories, Llc	2016-05-27	Not applicable	US
Acid Controller	Tablet	10 mg/1	Oral	H.E.B.	2015-10-23	Not applicable	US
Acid Controller	Tablet	20 mg/1	Oral	Walgreen	2006-09-26	Not applicable	US
Acid Controller	Tablet	20 mg/1	Oral	Shopko Stores Operating	2013-07-17	Not applicable	US
Acid Controller	Tablet	20 mg/1	Oral	Cvs Health	2006-09-28	Not applicable	US
Acid Controller Maximum Strength	Tablet	20 mg/1	Oral	Safeway	2007-06-15	Not applicable	US
Acid Controller Original Strength	Tablet	10 mg/1	Oral	Cvs Health	2009-10-17	Not applicable	US
Acid Controller Original Strength	Tablet	10 mg/1	Oral	Walgreen	2009-08-28	Not applicable	US
Acid Controller Original Strength	Tablet	10 mg/1	Oral	Safeway	2009-12-13	Not applicable	US
Acid Reducer	Tablet	10 mg/1	Oral	Publix Supermarkets, Inc.	2009-11-23	Not applicable	US
Acid Reducer	Tablet	10 mg/1	Oral	L. Perrigo Company	2014-07-23	Not applicable	US
Acid Reducer Maximum Strength	Tablet	20 mg/1	Oral	Rite Aid	2006-09-29	Not applicable	US
Acid Reducer Maximum Strength	Tablet	20 mg/1	Oral	Meijer Distribution	2006-09-29	Not applicable	US
Acid reducer original strength	Tablet	10 mg/1	Oral	Hannaford Brothers Company	2010-02-03	Not applicable	US
Acid Reducer Original Strength	Tablet	10 mg/1	Oral	Meijer Distribution	2009-10-14	Not applicable	US
Acid Reducer Original Strength	Tablet	10 mg/1	Oral	Hyvee	2009-10-19	Not applicable	US
Acid Reducer Original Strength	Tablet, coated	10 mg/1	Oral	Hyvee	2001-09-24	Not applicable	US
Acid Reducer Original Strength	Tablet	10 mg/1	Oral	Rite Aid	2009-09-10	Not applicable	US
Acid Reducer Original Strength	Tablet	10 mg/1	Oral	Western Family Foods	2009-10-23	Not applicable	US
Act	Tablet	10 mg	Oral	Novopharm Limited	Not applicable	Not applicable	Canada
Apo-famotidine	Tablet	10 mg	Oral	Apotex Corporation	1999-01-30	Not applicable	Canada
Basic Care famotidine	Tablet	20 mg/1	Oral	L. Perrigo Company	2017-08-10	Not applicable	US
Berkley and Jensen Acid Controller	Tablet	20 mg/1	Oral	BJWC	2006-11-08	Not applicable	US
Berkley and Jensen Famotidine	Tablet	20 mg/1	Oral	BJWC	2013-12-09	Not applicable	US
Calmicid AC Acid Reducer	Tablet, film coated	20 mg/1	Oral	Melaleuca, Inc.	2011-01-20	Not applicable	US
Care One Acid Reducer Original Strength	Tablet	10 mg/1	Oral	American Sales Company	2009-10-09	Not applicable	US
CareOne Acid Reducer	Tablet	10 mg/1	Oral	American Sales Company	2016-10-04	Not applicable	US
CareOne Acid Relief	Tablet	20 mg/1	Oral	American Sales Company	2016-09-22	Not applicable	US
Dg Health Heartburn Prevention	Tablet	20 mg/1	Oral	Dolgencorp	2010-02-14	Not applicable	US
Dg Health Heartburn Prevention Original Strength	Tablet	10 mg/1	Oral	Dolgencorp	2010-03-10	Not applicable	US
Equaline Heartburn Prevention	Tablet	20 mg/1	Oral	Supervalu	2014-12-05	Not applicable	US
Equaline Heartburn Prevention	Tablet	10 mg/1	Oral	Supervalu	2009-09-18	Not applicable	US
equate Acid Controller Original Strength	Tablet	10 mg/1	Oral	Walmart Stores	2009-10-30	Not applicable	US
Equate Famotidine	Tablet	10 mg/1	Oral	Walmart Stores	2016-01-04	Not applicable	US
Equate Famotidine	Tablet	20 mg/1	Oral	Walmart Stores	2007-05-02	Not applicable	US
Family Wellness Acid Reducer	Tablet	10 mg/1	Oral	Family Dollar Services	2013-09-19	Not applicable	US
Family Wellness Acid Reducer	Tablet	20 mg/1	Oral	Family Dollar Services	2013-08-30	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Value Merchandisers	2010-07-23	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Shopko Stores Operating	2010-07-23	Not applicable	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Select Brand	2012-02-13	Not applicable	US
Famotidine	Tablet	10 mg/1	Oral	Dr Reddy's Laboratories	2006-09-30	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Aurohealth LLC	2016-04-26	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	H.E.B.	2014-04-09	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Amerisource Bergen	2010-07-23	Not applicable	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Fred's	2010-06-25	Not applicable	US
Famotidine	Tablet, film coated, extended release	10 mg/1	Oral	Spirit Pharmaceuticals, Llc	2013-08-19	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Ipca Laboratories Limited	2010-07-23	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Walgreen	2013-11-07	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Magno Humphries, Inc.	2016-04-26	Not applicable	US
Famotidine	Tablet	10 mg/1	Oral	Walmart Stores	2012-07-05	Not applicable	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Chain Drug Marketing Association	2010-06-25	Not applicable	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Kinray	2011-10-03	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Walmart Stores	2011-11-04	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Wockhardt	2010-08-06	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Dr Reddy's Laboratories	2006-09-30	Not applicable	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Av Pak	2017-04-03	2017-08-24	US
Famotidine	Tablet	20 mg/1	Oral	bryant ranch prepack	2010-08-06	Not applicable	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Value Merchandisers	2010-06-25	Not applicable	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Teva	2014-05-15	Not applicable	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Aurohealth LLC	2016-04-26	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Walmart Stores	2016-04-26	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Wockhardt	2010-08-06	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Kinray	2012-02-15	Not applicable	US
Famotidine	Tablet	40 mg/1	Oral	H.J. Harkins Company	2001-04-16	Not applicable	US
Famotidine	Tablet	10 mg/1	Oral	Ipca Laboratories Limited	2010-06-25	Not applicable	US
Famotidine	Tablet	10 mg/1	Oral	Wockhardt	2005-03-07	Not applicable	US
Famotidine	Tablet	10 mg/1	Oral	IVAX Pharmaceuticals, Inc.	2010-02-18	2016-01-31	US
Famotidine	Tablet, film coated	10 mg/1	Oral	Magno Humphries, Inc.	2016-04-26	Not applicable	US
Famotidine	Tablet	20 mg/1	Oral	Safecor Health, LLC	2014-09-30	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Harris Teeter	2016-04-26	Not applicable	US
Famotidine	Tablet, film coated	20 mg/1	Oral	Chain Drug Marketing Association	2010-07-23	Not applicable	US
Famotidine	Tablet	10 mg/1	Oral	Nash Finch Company (Our Family)	2013-10-15	Not applicable	US
Famotidine - Acid Controller	Tablet, film coated	20 mg/1	Oral	Ohm Laboratories, Inc.	2010-07-23	Not applicable	US
Famotidine - Acid Controller	Tablet, film coated	10 mg/1	Oral	Win Co Foods, Llc,	2012-05-01	Not applicable	US
Famotidine - Acid Controller	Tablet, film coated	20 mg/1	Oral	Win Co Foods, Llc,	2012-05-01	Not applicable	US
Famotidine - Acid Controller	Tablet, film coated	10 mg/1	Oral	Ohm Laboratories, Inc.	2010-06-25	Not applicable	US
Famotidine original strength	Tablet	10 mg/1	Oral	EQUATE (Walmart Stores, Inc.)	2012-12-18	Not applicable	US
Good Neighbor Pharmacy Acid Reducer	Tablet, coated	10 mg/1	Oral	Amerisource Bergen	2001-06-05	Not applicable	US
Good Neighbor Pharmacy acid reducer	Tablet	10 mg/1	Oral	Carilion Materials Management	2009-10-07	Not applicable	US
Good Neighbor Pharmacy Acid Reducer	Tablet	10 mg/1	Oral	Amerisource Bergen	2016-12-12	Not applicable	US
Good Neighbor Pharmacy acid reducer	Tablet	10 mg/1	Oral	Amerisource Bergen	2009-10-07	Not applicable	US
Good Neighbor Pharmacy acid reducer	Tablet	10 mg/1	Oral	Carilion Materials Management	2009-10-07	Not applicable	US
Good Neighbor Pharmacy Acid Reducer Maximum Strength	Tablet	20 mg/1	Oral	Amerisource Bergen	2006-10-24	Not applicable	US
Good Sense Acid Reducer	Tablet	10 mg/1	Oral	L. Perrigo Company	2009-10-23	Not applicable	US
Good Sense Acid Reducer	Tablet	20 mg/1	Oral	L. Perrigo Company	2007-03-16	Not applicable	US
Harris Teeter Acid Reducer	Tablet	20 mg/1	Oral	Harris Teeter	2015-03-24	Not applicable	US
Health Mart Famotidine	Tablet	10 mg/1	Oral	Mc Kesson	2012-03-20	Not applicable	US
Health Mart Famotidine	Tablet	20 mg/1	Oral	Mc Kesson	2012-03-20	Not applicable	US
Healthy Accents Famotidine	Tablet	10 mg/1	Oral	Dza Brands,	2009-12-10	Not applicable	US
Healthy Accents Famotidine maximum strength	Tablet	20 mg/1	Oral	Dza Brands,	2008-04-13	Not applicable	US
Heartburn Prevention	Tablet	20 mg/1	Oral	Kroger	2015-02-05	Not applicable	US
Heartburn Prevention Acid Reducer	Tablet	10 mg/1	Oral	H.E.B.	2009-09-11	Not applicable	US
Heartburn Prevention Original Strength	Tablet	10 mg/1	Oral	Kroger	2009-10-09	Not applicable	US
Heartburn Relief	Tablet	10 mg/1	Oral	Select Corporation	2014-03-14	Not applicable	US
Heartburn Relief Original Strength	Tablet	10 mg/1	Oral	Avera Mc Kennan Hospital	2015-03-06	Not applicable	US
Heartburn Relief Original Strength	Tablet	10 mg/1	Oral	Major	2009-09-09	Not applicable	US
Humana Pharmacy Acid Reducer	Tablet	20 mg/1	Oral	Humana, Inc	2016-12-21	Not applicable	US
Kirkland Signature Acid Controller	Tablet	20 mg/1	Oral	Costco Wholesale	2007-05-24	Not applicable	US
Leader Acid Reducer Maximum Strength	Tablet	20 mg/1	Oral	Cardinal Health	2006-11-02	Not applicable	US
Leader Acid Reducer Original Strength	Tablet	10 mg/1	Oral	Cardinal Health	2009-10-14	Not applicable	US
Maalox H2 Acid Controller	Tablet	10 mg	Oral	Apotex Corporation	1997-11-30	2011-08-05	Canada
Major Heartburn Relief Maximum Strength	Tablet	20 mg/1	Oral	Major	2006-09-29	Not applicable	US
Maximum Strength	Tablet	20 mg/1	Oral	Publix Supermarkets, Inc.	2007-12-03	Not applicable	US
Maximum Strength Acid Reducer	Tablet	20 mg/1	Oral	Lnk International, Inc.	2013-08-01	2016-02-10	US
Maximum Strength Pepcid Ac	Tablet	20 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2007-04-16	Not applicable	Canada
Members Mark Famotidine	Tablet	20 mg/1	Oral	Sam's West, Inc	2006-09-28	Not applicable	US
Pepcid Ac	Tablet	10 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	Not applicable	Not applicable	Canada
Pepcid Ac	Tablet	10 mg	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	1996-07-23	Not applicable	Canada
Pepcid AC	Tablet, chewable	20 mg/1	Oral	Mc Neil Consumer Pharmaceuticals Co.	2008-02-01	2017-03-04	US
Pepcid Ac (chewable Tab) - 10mg	Tablet	10 mg	Oral	Merck Ltd.	1997-04-28	2007-07-31	Canada
Pepcid Ac Maximum Strength	Tablet, film coated	20 mg/1	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	2003-09-01	Not applicable	US
Pepcid AC Original Strength	Tablet, film coated	10 mg/1	Oral	Johnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division	1995-10-01	Not applicable	US
Peptic Guard	Tablet	10 mg	Oral	Mylan Pharmaceuticals	1997-12-12	2016-11-02	Canada
Premier Value Famotidine	Tablet, film coated	20 mg/1	Oral	Premier Value	2010-07-23	Not applicable	US
Premier Value Famotidine	Tablet, film coated	10 mg/1	Oral	Premier Value	2010-06-25	Not applicable	US
Rx Act Heartburn Prevention maximum strength	Tablet	20 mg/1	Oral	H.E.B.	2006-09-28	Not applicable	US
ShopRite Acid Reducer	Tablet	10 mg/1	Oral	Wakfern Food Corporation	2013-08-02	Not applicable	US
ShopRite Acid Reducer	Tablet	20 mg/1	Oral	Wakfern Food Corporation	2013-06-20	Not applicable	US
Signature Care Acid Controller	Tablet	10 mg/1	Oral	Safeway	2015-09-04	Not applicable	US
Signature Care Acid Controller maximum strength	Tablet	20 mg/1	Oral	Safeway	2015-09-04	Not applicable	US
Simply Right Famotidine	Tablet	20 mg/1	Oral	Sam's West, Inc	2012-01-26	Not applicable	US
Smart Sense Acid Reducer	Tablet	10 mg/1	Oral	Kmart Corporation	2010-12-14	Not applicable	US
Smart Sense Acid Reducer Maximum Strength	Tablet	20 mg/1	Oral	Kmart Corporation	2010-12-21	Not applicable	US
Smart Sense Famotidine	Tablet	20 mg/1	Oral	Kmart Corporation	2014-02-07	Not applicable	US
Smart Sense Famotidine	Tablet	10 mg/1	Oral	Kmart Corporation	2014-02-18	Not applicable	US
Sound Body Acid Reducer	Tablet	20 mg/1	Oral	Big Lots Stores, Inc.	2015-05-21	Not applicable	US
Sunmark Acid Reducer	Tablet, coated	10 mg/1	Oral	Mc Kesson	2003-08-11	Not applicable	US
Sunmark Acid Reducer	Tablet	10 mg/1	Oral	Mc Kesson	2009-09-10	Not applicable	US
SunMark Acid Reducer maximum strength	Tablet	20 mg/1	Oral	Mc Kesson	2007-06-18	Not applicable	US
TopCare Acid Reducer	Tablet	10 mg/1	Oral	Topco Associates	2009-09-11	Not applicable	US
TopCare Acid Reducer	Tablet	20 mg/1	Oral	Topco Associates	2006-09-28	Not applicable	US
Up and Up Acid Reducer Original Strength	Tablet	10 mg/1	Oral	Target Corporation.	2009-10-13	Not applicable	US
Up and Up acid reducer original strength	Tablet, coated	10 mg/1	Oral	Target Corporation.	2009-07-09	Not applicable	US
Up and Up Famotidine	Tablet	20 mg/1	Oral	Target Corporation.	2012-05-03	Not applicable	US
Up and Up Famotidine	Tablet	10 mg/1	Oral	Target Corporation.	2015-03-13	Not applicable	US

Unapproved/Other Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Famotidine	Injection, solution	2 mg/mL	Intravenous	Cantrell Drug Company	2014-06-11	Not applicable	US

International Brands

Name	Company
Amfamox	Not Available
Antodine	Not Available
Confobos	Not Available
Cronol	Not Available
Digervin	Not Available
Dispromil	Not Available
Duovel	Not Available
Durater	Not Available
Famocid	Not Available
Famosan	Not Available
Famotep	Not Available
Famox	Not Available
Famoxal	Not Available
Famtac	Not Available
Famulcer	Not Available
Fanosin	Not Available
Fluxid	Not Available
Gaster	Not Available
Lecedil	Not Available
Motiax	Not Available
Mylanta AR	Not Available
Notidin	Not Available
Nulceran	Not Available
Panalba	Not Available
Pepcid	Not Available
Pepcid RPD	Not Available
Pepcidin	Not Available
Pepcidine	Not Available
Pepdine	Not Available
Pepfamin	Not Available
Quamatel	Not Available
Renapepsa	Not Available
Rubacina	Not Available
Sedanium-R	Not Available
Supertidine	Not Available
Tairal	Not Available
Tipodex	Not Available
Ulfagel	Not Available
Ulfamid	Not Available
Ulgarine	Not Available
Vagostal	Not Available

Brand mixtures

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Acid Controller Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Safeway	2008-08-06	Not applicable	US
Acid Controller Complete dual action	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Walgreen	2008-07-30	Not applicable	US
Acid Reducer Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Rite Aid	2009-05-15	Not applicable	US
Acid Reducer Plus Antacid	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Rite Aid	2010-06-03	Not applicable	US
Berkley and Jensen Acid Controller Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	BJWC	2009-07-08	Not applicable	US
Care One Acid Reducer and Antacid Dual Action	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	American Sales Company	2008-08-01	Not applicable	US
Care One Acid Reducer plus Antacid Dual Action	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	American Sales Company	2008-08-01	Not applicable	US
CareOne Acid Reducer Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	American Sales Company	2016-09-29	Not applicable	US
Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Kroger	2008-10-09	Not applicable	US
Complete Dual Action	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Hyvee	2008-08-11	Not applicable	US
DG Health Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Dolgencorp	2009-07-16	Not applicable	US
Dual Action	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Publix Supermarkets, Inc.	2008-12-05	Not applicable	US
Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Kroger	2008-09-09	Not applicable	US
Duexis	Famotidine Ibuprofen	Tablet, coated	Oral	Horizon Pharma, Inc.	2011-04-29	Not applicable	US
DUO Fusion	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Boehringer Ingelheim	2016-03-01	Not applicable	US
Equaline Complete Dual Action	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Supervalu	2008-09-02	Not applicable	US
Equate Acid Reducer Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Walmart Stores	2008-08-08	Not applicable	US
Family Wellness Acid Controller Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Family Dollar Services	2012-08-02	Not applicable	US
Good Neighbor Pharmacy Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Amerisource Bergen	2008-08-04	Not applicable	US
Good Neighbor Pharmacy Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Amerisource Bergen	2016-01-29	Not applicable	US
Good Sense Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	L. Perrigo Company	2008-08-05	Not applicable	US
Good Sense Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	L. Perrigo Company	2016-01-06	Not applicable	US
Health Mart Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Mc Kesson	2013-01-05	Not applicable	US
Health Mart Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Mc Kesson	2016-01-12	Not applicable	US
Healthy Accents Famotidine Calcium Carbonate Magnesium Hydroxide	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Dza Brands,	2015-03-28	Not applicable	US
Leader Acid Reducer Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Cardinal Health	2012-05-02	Not applicable	US
Pepcid Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Mcneil Consumer Healthcare Division Of Johnson & Johnson Inc	2001-05-14	Not applicable	Canada
Preferred Plus Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Kinray	2015-04-27	Not applicable	US
ShopRite Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Wakfern Food Corporation	2013-06-18	Not applicable	US
ShopRite Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Wakfern Food Corporation	2016-02-05	Not applicable	US
Signature Care Acid Controller Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Safeway	2015-09-04	Not applicable	US
Signature Care Acid Reducer Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Safeway	2016-03-02	Not applicable	US
Simply Right Famotidine Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Sam's West, Inc	2012-03-10	Not applicable	US
Smart Sense Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Kmart Corporation	2011-06-21	Not applicable	US
Smart Sense Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Kmart Corporation	2014-04-29	Not applicable	US
Sunmark complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Mc Kesson	2012-12-04	Not applicable	US
Sunmark Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Mc Kesson	2016-01-14	Not applicable	US
Topcare Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Topco Associates	2008-08-05	Not applicable	US
TopCare Complete acid reducer plus antacid	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Topco Associates	2008-08-05	Not applicable	US
Topcare Dual Action Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Topco Associates	2016-02-29	Not applicable	US
Up and Up Acid Controller Complete Dual Action	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Target Corporation.	2009-07-31	Not applicable	US
Up and Up dual action acid controller complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Target Corporation.	2009-06-26	Not applicable	US
Up and Up Famotidine Complete	Calcium Carbonate Famotidine Magnesium Hydroxide	Tablet, chewable	Oral	Target Corporation.	2015-04-27	Not applicable	US

Categories

UNII

5QZO15J2Z8

CAS number

76824-35-6

Weight

Average: 337.445
Monoisotopic: 337.044934829

Chemical Formula

C₈H₁₅N₇O₂S₃

InChI Key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

InChI

InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

IUPAC Name

3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide

SMILES

NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1

Pharmacology

Indication

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Structured Indications

Pharmacodynamics

Famotidine, a competitive histamine H₂-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.

Mechanism of action

Famotidine binds competitively to H₂-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

Target	Kind	Pharmacological action	Actions	Organism	UniProt ID
Histamine H2 receptor	Protein	yes	antagonist	Human	P25021	details

Absorption

The bioavailability of oral doses is 40-45%.

Volume of distribution

Not Available

Protein binding

15-20%

Metabolism

Hepatic.

Route of elimination

Renal clearance is 250-450 mL/min, indicating some tubular excretion.

Half life

2.5-3.5 hours

Clearance

renal cl=250-450 mL/min

Toxicity

Intravenous, mouse: LD₅₀ = 244.4mg/kg; Oral, mouse: LD₅₀ = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.

Affected organisms

Humans and other mammals

Pathways

Pathway	Category	SMPDB ID
Famotidine Action Pathway	Drug action	SMP00231

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

Drug	Interaction	Drug group
2,5-Dimethoxy-4-ethylamphetamine	2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative activities of Famotidine.	Experimental, Illicit
3,4-Methylenedioxyamphetamine	3,4-Methylenedioxyamphetamine may decrease the sedative activities of Famotidine.	Experimental, Illicit
3,4-Methylenedioxymethamphetamine	3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Famotidine.	Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine	4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative activities of Famotidine.	Experimental, Illicit
Abiraterone	The metabolism of Famotidine can be decreased when combined with Abiraterone.	Approved
Amiodarone	Famotidine may increase the QTc-prolonging activities of Amiodarone.	Approved, Investigational
Amphetamine	Amphetamine may decrease the sedative activities of Famotidine.	Approved, Illicit
Anagrelide	Famotidine may increase the QTc-prolonging activities of Anagrelide.	Approved
Armodafinil	The metabolism of Famotidine can be decreased when combined with Armodafinil.	Approved, Investigational
Arsenic trioxide	Famotidine may increase the QTc-prolonging activities of Arsenic trioxide.	Approved, Investigational
Artemether	Famotidine may increase the QTc-prolonging activities of Artemether.	Approved
Asenapine	Famotidine may increase the QTc-prolonging activities of Asenapine.	Approved
Atazanavir	The serum concentration of Atazanavir can be decreased when it is combined with Famotidine.	Approved, Investigational
Azithromycin	Famotidine may increase the QTc-prolonging activities of Azithromycin.	Approved
Bedaquiline	Famotidine may increase the QTc-prolonging activities of Bedaquiline.	Approved
Benzphetamine	Benzphetamine may decrease the sedative activities of Famotidine.	Approved, Illicit
Benzylpenicilloyl Polylysine	Famotidine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.	Approved
Betahistine	The therapeutic efficacy of Betahistine can be decreased when used in combination with Famotidine.	Approved
Bortezomib	The metabolism of Famotidine can be decreased when combined with Bortezomib.	Approved, Investigational
Bosutinib	The serum concentration of Bosutinib can be decreased when it is combined with Famotidine.	Approved
Carbamazepine	The metabolism of Famotidine can be increased when combined with Carbamazepine.	Approved, Investigational
Cefditoren	The serum concentration of Cefditoren can be decreased when it is combined with Famotidine.	Approved
Cefpodoxime	Famotidine can cause a decrease in the absorption of Cefpodoxime resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved, Vet Approved
Cefuroxime	Famotidine can cause a decrease in the absorption of Cefuroxime resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Ceritinib	Famotidine may increase the QTc-prolonging activities of Ceritinib.	Approved
Chloramphenicol	The metabolism of Famotidine can be decreased when combined with Chloramphenicol.	Approved, Vet Approved
Chloroquine	Famotidine may increase the QTc-prolonging activities of Chloroquine.	Approved, Vet Approved
Chlorphentermine	Chlorphentermine may decrease the sedative activities of Famotidine.	Illicit, Withdrawn
Chlorpromazine	Famotidine may increase the QTc-prolonging activities of Chlorpromazine.	Approved, Vet Approved
Cholecalciferol	The metabolism of Famotidine can be decreased when combined with Cholecalciferol.	Approved, Nutraceutical
Cimetidine	The metabolism of Famotidine can be decreased when combined with Cimetidine.	Approved
Ciprofloxacin	Famotidine may increase the QTc-prolonging activities of Ciprofloxacin.	Approved, Investigational
Cisapride	Famotidine may increase the QTc-prolonging activities of Cisapride.	Approved, Investigational, Withdrawn
Citalopram	Famotidine may increase the QTc-prolonging activities of Citalopram.	Approved
Clarithromycin	Famotidine may increase the QTc-prolonging activities of Clarithromycin.	Approved
Clotrimazole	The metabolism of Famotidine can be decreased when combined with Clotrimazole.	Approved, Vet Approved
Clozapine	Famotidine may increase the QTc-prolonging activities of Clozapine.	Approved
Crizotinib	Famotidine may increase the QTc-prolonging activities of Crizotinib.	Approved
Cysteamine	The therapeutic efficacy of Cysteamine can be decreased when used in combination with Famotidine.	Approved, Investigational
Dabrafenib	The serum concentration of Famotidine can be decreased when it is combined with Dabrafenib.	Approved
Dasatinib	Famotidine can cause a decrease in the absorption of Dasatinib resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved, Investigational
Delavirdine	The serum concentration of Delavirdine can be decreased when it is combined with Famotidine.	Approved
Dexmethylphenidate	Famotidine can cause an increase in the absorption of Dexmethylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.	Approved
Dextroamphetamine	Dextroamphetamine may decrease the sedative activities of Famotidine.	Approved, Illicit
Diethylpropion	Diethylpropion may decrease the sedative activities of Famotidine.	Approved, Illicit
Disopyramide	Famotidine may increase the QTc-prolonging activities of Disopyramide.	Approved
Dofetilide	Famotidine may increase the QTc-prolonging activities of Dofetilide.	Approved
Dolasetron	Famotidine may increase the QTc-prolonging activities of Dolasetron.	Approved
Domperidone	Famotidine may increase the QTc-prolonging activities of Domperidone.	Approved, Investigational, Vet Approved
Dronedarone	Famotidine may increase the QTc-prolonging activities of Dronedarone.	Approved
Droperidol	Famotidine may increase the QTc-prolonging activities of Droperidol.	Approved, Vet Approved
Efavirenz	The metabolism of Famotidine can be decreased when combined with Efavirenz.	Approved, Investigational
Eliglustat	Famotidine may increase the QTc-prolonging activities of Eliglustat.	Approved
Erlotinib	The serum concentration of Erlotinib can be decreased when it is combined with Famotidine.	Approved, Investigational
Erythromycin	Famotidine may increase the QTc-prolonging activities of Erythromycin.	Approved, Vet Approved
Escitalopram	Famotidine may increase the QTc-prolonging activities of Escitalopram.	Approved, Investigational
Eslicarbazepine acetate	The metabolism of Famotidine can be decreased when combined with Eslicarbazepine acetate.	Approved
Esomeprazole	The metabolism of Famotidine can be decreased when combined with Esomeprazole.	Approved, Investigational
Etravirine	The metabolism of Famotidine can be decreased when combined with Etravirine.	Approved
Ferric Carboxymaltose	Famotidine can cause a decrease in the absorption of Ferric Carboxymaltose resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Ferric Citrate	Famotidine can cause a decrease in the absorption of Ferric Citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Ferric pyrophosphate	Famotidine can cause a decrease in the absorption of Ferric pyrophosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Flecainide	Famotidine may increase the QTc-prolonging activities of Flecainide.	Approved, Withdrawn
Fluconazole	The metabolism of Famotidine can be decreased when combined with Fluconazole.	Approved
Fluoxetine	Famotidine may increase the QTc-prolonging activities of Fluoxetine.	Approved, Vet Approved
Flupentixol	Famotidine may increase the QTc-prolonging activities of Flupentixol.	Approved, Withdrawn
Fluvoxamine	The metabolism of Famotidine can be decreased when combined with Fluvoxamine.	Approved, Investigational
Fosamprenavir	The serum concentration of Fosamprenavir can be decreased when it is combined with Famotidine.	Approved
Fosphenytoin	The metabolism of Famotidine can be increased when combined with Fosphenytoin.	Approved
Gadobenic acid	Famotidine may increase the QTc-prolonging activities of Gadobenic acid.	Approved
Gefitinib	The serum concentration of Gefitinib can be decreased when it is combined with Famotidine.	Approved, Investigational
Gemfibrozil	The metabolism of Famotidine can be decreased when combined with Gemfibrozil.	Approved
Gemifloxacin	Famotidine may increase the QTc-prolonging activities of Gemifloxacin.	Approved, Investigational
Goserelin	Famotidine may increase the QTc-prolonging activities of Goserelin.	Approved
Granisetron	Famotidine may increase the QTc-prolonging activities of Granisetron.	Approved, Investigational
Haloperidol	Famotidine may increase the QTc-prolonging activities of Haloperidol.	Approved
Hyaluronidase	The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Famotidine.	Approved, Investigational
Hydroxyamphetamine	Hydroxyamphetamine hydrobromide may decrease the sedative activities of Famotidine.	Approved
Ibutilide	Famotidine may increase the QTc-prolonging activities of Ibutilide.	Approved
Iloperidone	Famotidine may increase the QTc-prolonging activities of Iloperidone.	Approved
Indinavir	The serum concentration of Indinavir can be decreased when it is combined with Famotidine.	Approved
Iron	Famotidine can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Iron Dextran	Famotidine can cause a decrease in the absorption of Iron Dextran resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved, Vet Approved
Iron saccharate	Famotidine can cause a decrease in the absorption of Iron saccharate resulting in a reduced serum concentration and potentially a decrease in efficacy.	Approved
Isoniazid	The metabolism of Famotidine can be decreased when combined with Isoniazid.	Approved
Itraconazole	The serum concentration of Itraconazole can be decreased when it is combined with Famotidine.	Approved, Investigational
Ketoconazole	The serum concentration of Ketoconazole can be decreased when it is combined with Famotidine.	Approved, Investigational
Ketoconazole	The metabolism of Famotidine can be decreased when combined with Ketoconazole.	Approved, Investigational
Ledipasvir	The serum concentration of Ledipasvir can be decreased when it is combined with Famotidine.	Approved
Lenvatinib	Famotidine may increase the QTc-prolonging activities of Lenvatinib.	Approved
Leuprolide	Famotidine may increase the QTc-prolonging activities of Leuprolide.	Approved, Investigational
Levofloxacin	Famotidine may increase the QTc-prolonging activities of Levofloxacin.	Approved, Investigational
Lisdexamfetamine	Lisdexamfetamine may decrease the sedative activities of Famotidine.	Approved, Investigational
Lopinavir	Famotidine may increase the QTc-prolonging activities of Lopinavir.	Approved
Luliconazole	The serum concentration of Famotidine can be increased when it is combined with Luliconazole.	Approved
Lumacaftor	The serum concentration of Famotidine can be decreased when it is combined with Lumacaftor.	Approved
Lumefantrine	Famotidine may increase the QTc-prolonging activities of Lumefantrine.	Approved
Mephedrone	Mephedrone may decrease the sedative activities of Famotidine.	Investigational
Mephentermine	Mephentermine may decrease the sedative activities of Famotidine.	Approved
Mesalazine	The therapeutic efficacy of Mesalazine can be decreased when used in combination with Famotidine.	Approved
Methadone	Famotidine may increase the QTc-prolonging activities of Methadone.	Approved
Methamphetamine	Methamphetamine may decrease the sedative activities of Famotidine.	Approved, Illicit
Methylphenidate	Famotidine can cause an increase in the absorption of Methylphenidate resulting in an increased serum concentration and potentially a worsening of adverse effects.	Approved, Investigational
Mifepristone	Mifepristone may increase the QTc-prolonging activities of Famotidine.	Approved, Investigational
MMDA	MMDA may decrease the sedative activities of Famotidine.	Experimental, Illicit
Moclobemide	The metabolism of Famotidine can be decreased when combined with Moclobemide.	Approved
Modafinil	The metabolism of Famotidine can be decreased when combined with Modafinil.	Approved, Investigational
Moxifloxacin	Famotidine may increase the QTc-prolonging activities of Moxifloxacin.	Approved, Investigational
Nelfinavir	The serum concentration of Nelfinavir can be decreased when it is combined with Famotidine.	Approved
Nicardipine	The metabolism of Famotidine can be decreased when combined with Nicardipine.	Approved
Nilotinib	The serum concentration of Nilotinib can be decreased when it is combined with Famotidine.	Approved, Investigational
Ofloxacin	Famotidine may increase the QTc-prolonging activities of Ofloxacin.	Approved
Omeprazole	The metabolism of Famotidine can be decreased when combined with Omeprazole.	Approved, Investigational, Vet Approved
Ondansetron	Famotidine may increase the QTc-prolonging activities of Ondansetron.	Approved
Paliperidone	Famotidine may increase the QTc-prolonging activities of Paliperidone.	Approved
Panobinostat	Famotidine may increase the QTc-prolonging activities of Panobinostat.	Approved, Investigational
Pantoprazole	The metabolism of Famotidine can be decreased when combined with Pantoprazole.	Approved
Pazopanib	The serum concentration of Pazopanib can be decreased when it is combined with Famotidine.	Approved
Pentamidine	Famotidine may increase the QTc-prolonging activities of Pentamidine.	Approved
Perflutren	Famotidine may increase the QTc-prolonging activities of Perflutren.	Approved
Phentermine	Phentermine may decrease the sedative activities of Famotidine.	Approved, Illicit
Phenytoin	The metabolism of Famotidine can be increased when combined with Phenytoin.	Approved, Vet Approved
Pimozide	Famotidine may increase the QTc-prolonging activities of Pimozide.	Approved
Posaconazole	The serum concentration of Posaconazole can be decreased when it is combined with Famotidine.	Approved, Investigational, Vet Approved
Primaquine	Famotidine may increase the QTc-prolonging activities of Primaquine.	Approved
Procainamide	Famotidine may increase the QTc-prolonging activities of Procainamide.	Approved
Promazine	Famotidine may increase the QTc-prolonging activities of Promazine.	Approved, Vet Approved
Propafenone	Famotidine may increase the QTc-prolonging activities of Propafenone.	Approved
Pseudoephedrine	Pseudoephedrine may decrease the sedative activities of Famotidine.	Approved
Quetiapine	Famotidine may increase the QTc-prolonging activities of Quetiapine.	Approved
Quinidine	Famotidine may increase the QTc-prolonging activities of Quinidine.	Approved
Quinine	Famotidine may increase the QTc-prolonging activities of Quinine.	Approved
Rifampicin	The metabolism of Famotidine can be increased when combined with Rifampicin.	Approved
Rilpivirine	The serum concentration of Rilpivirine can be decreased when it is combined with Famotidine.	Approved
Risedronate	The serum concentration of Risedronate can be increased when it is combined with Famotidine.	Approved, Investigational
Ritobegron	Ritobegron may decrease the sedative activities of Famotidine.	Investigational
Saquinavir	The serum concentration of Saquinavir can be increased when it is combined with Famotidine.	Approved, Investigational
Sertraline	The metabolism of Famotidine can be decreased when combined with Sertraline.	Approved
Sotalol	Famotidine may increase the QTc-prolonging activities of Sotalol.	Approved
Stiripentol	The metabolism of Famotidine can be decreased when combined with Stiripentol.	Approved
Sulfisoxazole	Famotidine may increase the QTc-prolonging activities of Sulfisoxazole.	Approved, Vet Approved
Telavancin	Famotidine may increase the QTc-prolonging activities of Telavancin.	Approved
Telithromycin	Famotidine may increase the QTc-prolonging activities of Telithromycin.	Approved
Tetrabenazine	Famotidine may increase the QTc-prolonging activities of Tetrabenazine.	Approved
Thioridazine	Famotidine may increase the QTc-prolonging activities of Thioridazine.	Withdrawn
Ticlopidine	The metabolism of Famotidine can be decreased when combined with Ticlopidine.	Approved
Topiramate	The metabolism of Famotidine can be decreased when combined with Topiramate.	Approved
Toremifene	Famotidine may increase the QTc-prolonging activities of Toremifene.	Approved, Investigational
Tranylcypromine	The metabolism of Famotidine can be decreased when combined with Tranylcypromine.	Approved
Vandetanib	Famotidine may increase the QTc-prolonging activities of Vandetanib.	Approved
Varenicline	The serum concentration of Varenicline can be increased when it is combined with Famotidine.	Approved, Investigational
Vemurafenib	Famotidine may increase the QTc-prolonging activities of Vemurafenib.	Approved
Voriconazole	The metabolism of Famotidine can be decreased when combined with Voriconazole.	Approved, Investigational
Ziprasidone	Famotidine may increase the QTc-prolonging activities of Ziprasidone.	Approved
Zuclopenthixol	Famotidine may increase the QTc-prolonging activities of Zuclopenthixol.	Approved, Investigational

Food Interactions

Avoid alcohol.
Limit caffeine intake.
Take without regard to meals, food may slightly increase the product's bioavailability.

References

Synthesis Reference

Montserrat Ballester-Rodes, Francisco E. Palomo-Nicolau, Antonio L. Palomo-Coli, "Famotidine polymorphic forms and their preparation process." U.S. Patent US5021582, issued March, 1987.

US5021582

General References

Not Available

External Links

Resource	Link
Human Metabolome Database (HMDB)	HMDB01919
KEGG Drug	D00318
PubChem Compound	3325
PubChem Substance	46507397
ChemSpider	3208
BindingDB	50036754
ChEBI	4975
ChEMBL	CHEMBL902
Therapeutic Targets Database	DAP000341
PharmGKB	PA449586
Drug Product Database	1395
RxList	http://www.rxlist.com/cgi/generic/famot.htm
Drugs.com	http://www.drugs.com/famotidine.html
PDRhealth	http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/pep1325.shtml
Wikipedia	Famotidine

ATC Codes

A02BA03 — Famotidine

A02BA53 — Famotidine, combinations

AHFS Codes

56:28.12

PDB Entries

Not Available

FDA label

Download (1.05 MB)

MSDS

Download (73.8 KB)

Clinical Trials

Phase	Status	Purpose	Conditions	Count
1	Active Not Recruiting	Treatment	Healthy Volunteers	1
1	Completed	Not Available	Healthy Volunteers / Lupus / Psoriasis	1
1	Completed	Not Available	Human Immunodeficiency Virus (HIV) Infections	1
1	Completed	Basic Science	Healthy Volunteers	1
1	Completed	Health Services Research	Healthy Volunteers	1
1	Completed	Treatment	Bioavailability	2
1	Completed	Treatment	Cancers / Colorectal Cancers / Melanoma / Non-Small-Cell Lung Cancer (NSCLC) / Thyroid Papillary Carcinoma	1
1	Completed	Treatment	Healthy Volunteers	1
1	Completed	Treatment	Human Immunodeficiency Virus (HIV) Infections / Infection, Human Immunodeficiency Virus I	1
1	Completed	Treatment	Psoriasis	1
1	Recruiting	Screening	Fibrosis	1
2	Completed	Treatment	Acute Cerebrovascular Accidents / Edema of the cerebrum	1
2	Completed	Treatment	Dyskinesias	1
2	Enrolling by Invitation	Treatment	Malignant Neoplasm of Stomach	1
2	Not Yet Recruiting	Treatment	Plasmodium Infections	1
2	Recruiting	Treatment	Plasma Cell Myeloma	1
2, 3	Completed	Treatment	Reflux, Gastroesophageal	1
2, 3	Recruiting	Treatment	Malaria caused by Plasmodium falciparum	1
2, 3	Recruiting	Treatment	Schizophrenic Disorders	1
3	Completed	Prevention	Ulcers	1
3	Completed	Treatment	Erosive Esophagitis(EE)	1
3	Completed	Treatment	Peptic Ulcer Bleeding / Upper Gastrointestinal Hemorrhage	1
3	Completed	Treatment	Reflux, Gastroesophageal	1
4	Active Not Recruiting	Prevention	Peptic Ulcers	1
4	Completed	Not Available	HIV Disease	1
4	Completed	Not Available	Human Immunodeficiency Virus (HIV) Infections	1
4	Completed	Prevention	Marginal Ulcers	1
4	Completed	Prevention	Peptic Ulcer/Erosions	1
4	Completed	Prevention	Ulcers	1
4	Completed	Treatment	Heartburn	1
4	Completed	Treatment	Juvenile Idiopathic Arthritis (JIA)	1
4	Completed	Treatment	Schizophrenic Disorders	1
4	Recruiting	Treatment	Rheumatoid Arthritis	1
4	Unknown Status	Treatment	Aspirin / Indigestion	1
Not Available	Active Not Recruiting	Treatment	Metastatic Melanoma	1
Not Available	Completed	Not Available	Anemias / Iron Deficiency / Plasmodium Infections / Schistosomiasis Infection	1
Not Available	Completed	Not Available	Community Acquired Pneumonia (CAP) / Gastroesophageal Reflux Disease (GERD)	1
Not Available	Completed	Not Available	Healthy Volunteers	2
Not Available	Completed	Not Available	Rhytidoplasty	1
Not Available	Completed	Treatment	Plasmodium Infections	1
Not Available	Recruiting	Prevention	Peptic Ulcers	2
Not Available	Recruiting	Supportive Care	Cancer, Breast / Prophylaxis against postoperative nausea and vomiting	1
Not Available	Unknown Status	Not Available	Parasitemia	1

Pharmacoeconomics

Manufacturers

Lupin ltd
Navinta llc
Salix pharmaceuticals inc
Akorn strides llc
Apotex inc richmond hill
Apothecon inc div bristol myers squibb
App pharmaceuticals llc
Baxter healthcare corp anesthesia and critical care
Baxter healthcare corp
Bedford laboratories div ben venue laboratories inc
Hospira inc
Ben venue laboratories inc
Claris lifesciences ltd
Abbott laboratories
Baxter healthcare internati0nal specialty therapies div
Merck research laboratories div merck co inc
L perrigo co
Schwarz pharma inc
Actavis elizabeth llc
Alembic ltd
Apotex inc
Carlsbad technology inc
Dr reddys laboratories ltd
Genpharm inc
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
Mutual pharmaceutical co inc
Mylan pharmaceuticals inc
Perrigo co
Ranbaxy laboratories inc
Sandoz inc
Teva pharmaceuticals usa inc
Watson laboratories inc
Wockhardt ltd
Wockhardt americas inc

Packagers

Advanced Pharmaceutical Services Inc.
Akorn Inc.
Amerisource Health Services Corp.
APP Pharmaceuticals
A-S Medication Solutions LLC
Atlantic Biologicals Corporation
Baxter International Inc.
Bedford Labs
Ben Venue Laboratories Inc.
Bryant Ranch Prepack
Cardinal Health
Carlsbad Technology Inc.
Chain Drug
Corepharma LLC
CVS Pharmacy
Dispensing Solutions
Diversified Healthcare Services Inc.
Doctor Reddys Laboratories Ltd.
H.J. Harkins Co. Inc.
Heartland Repack Services LLC
Hospira Inc.
Ivax Pharmaceuticals
Johnson & Johnson Healthcare
Kaiser Foundation Hospital
Lake Erie Medical and Surgical Supply
Legacy Pharmaceuticals Packaging LLC
Lupin Pharmaceuticals Inc.
Major Pharmaceuticals
Mckesson Corp.
Medisca Inc.
Merck & Co.
Murfreesboro Pharmaceutical Nursing Supply
Mylan
Northstar Rx LLC
Nucare Pharmaceuticals Inc.
PCA LLC
PD-Rx Pharmaceuticals Inc.
Perrigo Co.
Pharmaceutical Utilization Management Program VA Inc.
Pharmedium
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prepak Systems Inc.
Rebel Distributors Corp.
Redpharm Drug
Remedy Repack
Salix Pharmaceuticals
Sandhills Packaging Inc.
Southwood Pharmaceuticals
Strides Arcolab Limited
Teva Pharmaceutical Industries Ltd.
UDL Laboratories
Vangard Labs Inc.
Walgreen Co.
Watson Pharmaceuticals
Wockhardt Ltd.
Yung Shin Pharmaceutical Industry Ltd.
Zydus Pharmaceuticals

Dosage forms

Form	Route	Strength
Tablet	Oral	20 mg
Tablet	Oral	40 mg
Tablet, coated	Oral
For suspension	Oral	40 mg/5mL
Injection	Intravenous	10 mg/mL
Injection, solution	Intravenous	10 mg/mL
Injection, solution	Intravenous	2 mg/mL
Injection, solution	Intravenous	20 mg/50mL
Powder, for solution	Oral	40 mg/5mL
Powder, for suspension	Oral	40 mg/5mL
Tablet	Oral	40 mg/1
Tablet, film coated	Oral	10 mg/1
Tablet, film coated	Oral	20 mg/1
Tablet, film coated	Oral	40 mg/1
Tablet, film coated, extended release	Oral	10 mg/1
Solution	Intravenous	10 mg
Tablet	Oral	10 mg/1
Tablet, chewable	Oral
Tablet	Oral	20 mg/1
Tablet	Oral	10 mg
Tablet, chewable	Oral	20 mg/1
Tablet, coated	Oral	10 mg/1

Prices

Unit description	Cost	Unit
Pepcid 30 40 mg tablet Bottle	125.5USD	bottle
Pepcid 40 mg/5ml Suspension 50ml Bottle	123.88USD	bottle
Pepcid 30 20 mg tablet Bottle	64.13USD	bottle
Mylanta Double-Strength 400-400-40 mg/5ml Suspension 710ml Bottle	10.15USD	bottle
Mylanta 200-200-20 mg/5ml Suspension 710ml Bottle	9.23USD	bottle
Mylanta 200-200-20 mg/5ml Suspension 355ml Bottle	7.99USD	bottle
Mylanta Double-Strength 400-400-40 mg/5ml Suspension 355ml Bottle	7.99USD	bottle
Famotidine 40 mg tablet	3.43USD	tablet
Pepcid 40 mg tablet	3.02USD	tablet
Famotidine powder	2.74USD	g
Famotidine 20 mg tablet	1.76USD	tablet
Pepcid 20 mg tablet	1.6USD	tablet
Apo-Famotidine 40 mg Tablet	1.11USD	tablet
Mylan-Famotidine 40 mg Tablet	1.11USD	tablet
Novo-Famotidine 40 mg Tablet	1.11USD	tablet
Nu-Famotidine 40 mg Tablet	1.11USD	tablet
Pepcid ac 10 mg tablet	0.72USD	tablet
Famotidine 40 mg/4 ml vial	0.71USD	ml
Famotidine 500 mg/50 ml vial	0.71USD	ml
Apo-Famotidine 20 mg Tablet	0.62USD	tablet
Mylan-Famotidine 20 mg Tablet	0.62USD	tablet
Novo-Famotidine 20 mg Tablet	0.62USD	tablet
Nu-Famotidine 20 mg Tablet	0.62USD	tablet
Pepcid ac 20 mg tablet	0.58USD	tablet
Famotidine-ns 20 mg/10 ml syrg	0.54USD	ml
Pepcid ac 10 mg gelcap	0.48USD	capsule
Pepcid complete tablet chew	0.4USD	tablet
Famotidine 20 mg/2 ml vial	0.36USD	ml
Famotidine 10 mg/ml vial	0.28USD	ml
CVS Pharmacy acid controller 20 mg tablet	0.24USD	tablet
CVS Pharmacy acid controller tablet	0.24USD	tablet
Acid reducer 20 mg tablet	0.22USD	tablet
Acid controller 10 mg tablet	0.21USD	tablet
Mylanta gas 125 mg tablet chew	0.16USD	tablet
Acid reducer 10 mg tablet	0.15USD	tablet
Famotidine 10 mg tablet	0.15USD	tablet
Famotidine 20 mg piggyback	0.13USD	ml
Mylanta gelcap	0.12USD	capsule
Mylanta ultimate-strength tablet	0.07USD	tablet
Mylanta ultra chew tablet	0.06USD	tablet
Pv acid reducer 10 mg tablet	0.05USD	tablet
Mylanta liq	0.02USD	ml
Mylanta supreme antacid liq	0.02USD	ml

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US5075114	No	1993-05-23	2010-05-23	US
CA2178277	No	2000-11-14	2016-06-05	Canada
CA2052679	No	1997-12-02	2011-08-21	Canada
US6221392	No	1998-04-09	2018-04-09	US
US6024981	No	1998-04-09	2018-04-09	US
US5854267	Yes	1996-06-29	2016-06-29	US
US6814978	Yes	2002-02-26	2022-02-26	US
US5989588	Yes	1998-03-30	2018-03-30	US
US8067451	No	2006-07-18	2026-07-18	US
US8501228	No	2006-07-18	2026-07-18	US
US8318202	No	2006-07-18	2026-07-18	US
US8449910	No	2006-07-18	2026-07-18	US
US8309127	No	2006-07-18	2026-07-18	US
US8067033	No	2006-07-18	2026-07-18	US
US5667794	Yes	1995-11-02	2015-11-02	US

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	163.5 °C	PhysProp
water solubility	1000 mg/L (at 20 °C)	MERCK INDEX (1996)
logP	-0.64	ISLAM,MS & NARURKAR,MM (1993)

Predicted Properties

Property	Value	Source
Water Solubility	0.271 mg/mL	ALOGPS
logP	-0.2	ALOGPS
logP	-2	ChemAxon
logS	-3.1	ALOGPS
pKa (Strongest Acidic)	9.29	ChemAxon
pKa (Strongest Basic)	8.38	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	175.83 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	80.46 m³·mol^-1	ChemAxon
Polarizability	32.02 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted ADMET features

Property	Value	Probability
Human Intestinal Absorption	+	0.9156
Blood Brain Barrier	+	0.9382
Caco-2 permeable	-	0.8957
P-glycoprotein substrate	Non-substrate	0.5839
P-glycoprotein inhibitor I	Non-inhibitor	0.9044
P-glycoprotein inhibitor II	Non-inhibitor	0.8701
Renal organic cation transporter	Non-inhibitor	0.6802
CYP450 2C9 substrate	Non-substrate	0.7898
CYP450 2D6 substrate	Non-substrate	0.9115
CYP450 3A4 substrate	Non-substrate	0.7558
CYP450 1A2 substrate	Non-inhibitor	0.9045
CYP450 2C9 inhibitor	Non-inhibitor	0.9071
CYP450 2D6 inhibitor	Non-inhibitor	0.9231
CYP450 2C19 inhibitor	Non-inhibitor	0.9025
CYP450 3A4 inhibitor	Non-inhibitor	0.8309
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.9297
Ames test	Non AMES toxic	0.5827
Carcinogenicity	Non-carcinogens	0.9182
Biodegradation	Not ready biodegradable	0.9324
Rat acute toxicity	1.9523 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.8366
hERG inhibition (predictor II)	Inhibitor	0.6481

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum Type	Description	Splash Key
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS	Not Available
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)	splash10-000i-0029000000-087ab7a1109f0568738d	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)	splash10-0udi-0900000000-d8a9ef8fc58c0c705232	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)	splash10-000i-0900000000-e245f325e8c6f31a5fd0	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-qTof , Positive	Not Available
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-qTof , Positive	Not Available
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , negative	splash10-0005-0940000000-a2bd7381011d29592cea	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-0a4i-0090000000-10306158f008021f19a5	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-014i-0090000000-90a70a7303c968311864	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-001i-0090000000-ac0250ad61059e58f431	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , positive	splash10-0002-0090000000-235724a37e50732fdf94	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-0a4r-0950000000-0c16a77af1ba782fa15a	View in MoNA
LC-MS/MS	LC-MS/MS Spectrum - , positive	splash10-0a4r-0950000000-02af106b93d1423b1342	View in MoNA
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	Not Available
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	Not Available
1D NMR	1H NMR Spectrum	Not Available
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available

Taxonomy

Description

This compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Azoles

Sub Class

Thiazoles

Direct Parent

2,4-disubstituted thiazoles

Alternative Parents

Organic sulfuric acids and derivatives / Heteroaromatic compounds / Guanidines / Sulfenyl compounds / Propargyl-type 1,3-dipolar organic compounds / Dialkylthioethers / Azacyclic compounds / Amidines / Organopnictogen compounds / Organic oxides

Substituents

2,4-disubstituted 1,3-thiazole / Organic sulfuric acid or derivatives / Heteroaromatic compound / Guanidine / Amidine / Azacycle / Dialkylthioether / Organic 1,3-dipolar compound / Propargyl-type 1,3-dipolar organic compound / Sulfenyl compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

sulfonamide, guanidines, 1,3-thiazole (CHEBI:4975 )

Targets

Details

1. Histamine H2 receptor

Kind: Protein
Organism: Human
Pharmacological action: yes
Actions: antagonist

General Function:: Histamine receptor activity
Specific Function:: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) si...
Gene Name:: HRH2
Uniprot ID:: P25021
Uniprot Name:: Histamine H2 receptor
Molecular Weight:: 40097.65 Da

References

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Fukuda M, Tanaka S, Suzuki S, Kusama K, Kaneko T, Sakashita H: Cimetidine induces apoptosis of human salivary gland tumor cells. Oncol Rep. 2007 Mar;17(3):673-8. [PubMed:17273750 ]
Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. Epub 2006 May 24. [PubMed:16723495 ]
Kesiova M, Alexandrova A, Yordanova N, Kirkova M, Todorov S: Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacol Rep. 2006 Mar-Apr;58(2):221-8. [PubMed:16702624 ]
Lesclous P, Schramm F, Gallina S, Baroukh B, Guez D, Saffar JL: Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats. Exp Physiol. 2006 May;91(3):561-70. Epub 2006 Mar 2. [PubMed:16513821 ]
Amagase K, Okabe S: On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion. J Pharmacol Sci. 2003 Jun;92(2):124-36. [PubMed:12832840 ]
Weydert JA, Ball TM, Davis MF: Systematic review of treatments for recurrent abdominal pain. Pediatrics. 2003 Jan;111(1):e1-11. [PubMed:12509588 ]
Miyata K, Kamato T, Nishida A, Honda K: Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol. 1991 Feb;55(2):211-22. [PubMed:2067140 ]
Leurs R, Brozius MM, Smit MJ, Bast A, Timmerman H: Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine. Br J Pharmacol. 1991 Jan;102(1):179-85. [PubMed:1646056 ]
Inan A, Sen M, Surgit O, Ergin M, Bozer M: Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo). 2009;64(6):567-70. [PubMed:19578661 ]
Ojiako K, Shingala H, Schorr C, Gerber DR: Famotidine versus pantoprazole for preventing bleeding in the upper gastrointestinal tract of critically ill patients receiving mechanical ventilation. Am J Crit Care. 2008 Mar;17(2):142-7. [PubMed:18310651 ]

Enzymes

Details

1. Cytochrome P450 2C19

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrate

General Function:: Steroid hydroxylase activity
Specific Function:: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:: CYP2C19
Uniprot ID:: P33261
Uniprot Name:: Cytochrome P450 2C19
Molecular Weight:: 55930.545 Da

References

Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Details

1. Solute carrier family 22 member 2

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: inhibitor

General Function:: Quaternary ammonium group transmembrane transporter activity
Specific Function:: Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:: SLC22A2
Uniprot ID:: O15244
Uniprot Name:: Solute carrier family 22 member 2
Molecular Weight:: 62579.99 Da

References

Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [PubMed:15496291 ]

Details

2. Solute carrier family 22 member 8

Kind: Protein
Organism: Human
Pharmacological action: unknown
Actions: substrateinhibitor

General Function:: Sodium-independent organic anion transmembrane transporter activity
Specific Function:: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:: SLC22A8
Uniprot ID:: Q8TCC7
Uniprot Name:: Solute carrier family 22 member 8
Molecular Weight:: 59855.585 Da

References

Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [PubMed:15496291 ]
Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. [PubMed:15100168 ]
Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y: Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther. 2006 Mar;316(3):1187-94. Epub 2005 Nov 16. [PubMed:16291876 ]

Drug created on June 13, 2005 07:24 / Updated on September 01, 2017 10:34

Structure for DB00927 (Famotidine)

Targets

References

Enzymes

References

Transporters

References

References