Identification
- Name
- Famotidine
- Accession Number
- DB00927 (APRD00296)
- Type
- Small Molecule
- Groups
- Approved
- Description
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
- Structure
- Synonyms
- (1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide
- 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide
- 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine
- Famotidina
- Famotidine
- Famotidinum
- N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide
- External IDs
- L 643341 / MK-208 / YM-11170
- Product Images
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Bci Famotidine Tablet 20 mg Oral Baker Cummins Inc Not applicable Not applicable Canada Bci Famotidine Tablet 40 mg Oral Baker Cummins Inc Not applicable Not applicable Canada Famotidine Powder, for suspension 40 mg/5mL Oral Paddock Laboratories, Inc. 2010-05-28 2015-04-30 US Famotidine 10mg Tablet 10 mg Oral Laboratoire Riva Inc Not applicable Not applicable Canada Famotidine Injection Solution 10 mg Intravenous Mylan Pharmaceuticals Not applicable Not applicable Canada Famotidine Injection Solution 10 mg Intravenous Hospira, Inc. Not applicable Not applicable Canada Famotidine Injection Solution 10 mg Intravenous Mylan Pharmaceuticals Not applicable Not applicable Canada Famotidine Injection Solution 10 mg Intravenous Fresenius Kabi Not applicable Not applicable Canada Famotidine IV Injection Solution 10 mg Intravenous Teva Not applicable Not applicable Canada Famotidine IV Injection Solution 10 mg Intravenous Teva Not applicable Not applicable Canada - Generic Prescription Products
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End 7 Select Acid Controller Tablet 20 mg/1 Oral 7 Eleven 2014-08-05 Not applicable US Acid Control Tablet 10 mg Oral Teva 1997-06-17 Not applicable Canada Acid Control Tablet 20 mg Oral Apotex Corporation 2014-04-28 Not applicable Canada Acid Control Tablet 10 mg Oral Vita Health Products Inc 1998-10-27 Not applicable Canada Acid Control Tablet 10 mg Oral Pendopharm Division Of De Pharmascience Inc 1997-09-08 2015-01-19 Canada Acid Control Tablet 10 mg Oral Apotex Corporation 2000-07-11 Not applicable Canada Acid Control Original Strength Tablet 10 mg/1 Oral Medicine Shoppe International 2009-10-19 2012-04-09 US Acid Controller Tablet 20 mg/1 Oral CVS Health 2006-09-28 Not applicable US Acid Controller Tablet 20 mg/1 Oral Shopko Stores Operating 2013-07-17 Not applicable US Acid Controller Tablet 10 mg/1 Oral H.E.B. 2015-10-23 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Acid Controller Complete Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Shopko Stores Operating 2013-06-05 2016-11-16 US Acid Controller Complete Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Shopko Stores Operating 2013-06-05 2017-01-15 US Acid Controller Complete Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Safeway 2008-08-06 2017-01-19 US Acid Controller Complete dual action Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Walgreen 2008-07-30 2017-07-25 US Acid Controller Complete dual action Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Walgreen 2008-07-30 Not applicable US Acid Reducer Complete Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Shopko Stores Operating Co., LLC 2016-01-12 Not applicable US Acid Reducer Complete Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Shopko Stores Operating Co., LLC 2016-01-06 Not applicable US Acid Reducer Complete Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Walgreen Company 2016-01-29 Not applicable US Acid Reducer Complete Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Rite Aid 2009-05-15 2017-09-08 US Acid Reducer Complete Famotidine (10 mg/1) + Calcium Carbonate (800 mg/1) + Magnesium hydroxide (165 mg/1) Tablet, chewable Oral Walgreen Company 2016-01-29 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Famotidine Famotidine (2 mg/1mL) Injection, solution Intravenous Cantrell Drug Company 2014-06-11 Not applicable US - International/Other Brands
- Amfamox / Antodine / Confobos / Cronol / Digervin / Dispromil / Duovel / Durater / Famocid / Famosan / Famotep / Famox / Famoxal / Famtac / Famulcer / Fanosin / Fluxid / Gaster / Lecedil / Motiax / Mylanta AR / Notidin / Nulceran / Panalba / Pepcid / Pepcid RPD / Pepcidin / Pepcidine / Pepdine / Pepfamin / Quamatel / Renapepsa / Rubacina / Sedanium-R / Supertidine / Tairal / Tipodex / Ulfagel / Ulfamid / Ulgarine / Vagostal
- Categories
- Acid Reducers
- Alimentary Tract and Metabolism
- Anti-Ulcer Agents
- Drugs for Acid Related Disorders
- Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)
- Gastric Acid Lowering Agents
- Gastrointestinal Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H2 Antagonists
- Neurotransmitter Agents
- OAT3/SLC22A8 Inhibitors
- OAT3/SLC22A8 Substrates
- OCT2 Inhibitors
- Potential QTc-Prolonging Agents
- QTc Prolonging Agents
- Sulfur Compounds
- Thiazoles
- UNII
- 5QZO15J2Z8
- CAS number
- 76824-35-6
- Weight
- Average: 337.445
Monoisotopic: 337.044934829 - Chemical Formula
- C8H15N7O2S3
- InChI Key
- XUFQPHANEAPEMJ-UHFFFAOYSA-N
- InChI
- InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
- IUPAC Name
- 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide
- SMILES
- NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1
Pharmacology
- Indication
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
- Associated Conditions
- Pharmacodynamics
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
- Mechanism of action
Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.
Target Actions Organism AHistamine H2 receptor antagonistHumans - Absorption
The bioavailability of oral doses is 40-45%.
- Volume of distribution
- Not Available
- Protein binding
15-20%
- Metabolism
Hepatic.
- Route of elimination
Renal clearance is 250-450 mL/min, indicating some tubular excretion.
- Half life
2.5-3.5 hours
- Clearance
- renal cl=250-450 mL/min
- Toxicity
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
- Affected organisms
- Humans and other mammals
- Pathways
Pathway Category Famotidine Action Pathway Drug action - Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
Drug Interaction 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid Famotidine can cause a decrease in the absorption of 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy. 2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative and stimulatory activities of Famotidine. 2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative and stimulatory activities of Famotidine. 3,4-Methylenedioxyamphetamine 3,4-Methylenedioxyamphetamine may decrease the sedative and stimulatory activities of Famotidine. 4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative and stimulatory activities of Famotidine. Abafungin Famotidine can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy. Abexinostat The risk or severity of QTc prolongation can be increased when Famotidine is combined with Abexinostat. Acebutolol The risk or severity of QTc prolongation can be increased when Famotidine is combined with Acebutolol. Aceprometazine The risk or severity of QTc prolongation can be increased when Famotidine is combined with Aceprometazine. Acetyldigoxin The risk or severity of QTc prolongation can be increased when Famotidine is combined with Acetyldigoxin. - Food Interactions
- Avoid alcohol.
- Limit caffeine intake.
- Take without regard to meals, food may slightly increase the product's bioavailability.
References
- Synthesis Reference
Montserrat Ballester-Rodes, Francisco E. Palomo-Nicolau, Antonio L. Palomo-Coli, "Famotidine polymorphic forms and their preparation process." U.S. Patent US5021582, issued March, 1987.
US5021582- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0001919
- KEGG Drug
- D00318
- PubChem Compound
- 3325
- PubChem Substance
- 46507397
- BindingDB
- 50036754
- ChEBI
- 4975
- ChEMBL
- CHEMBL902
- Therapeutic Targets Database
- DAP000341
- PharmGKB
- PA449586
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- PDRhealth
- PDRhealth Drug Page
- Wikipedia
- Famotidine
- ATC Codes
- A02BA53 — Famotidine, combinations
- A02BA — H2-receptor antagonists
- A02B — DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
- A02 — DRUGS FOR ACID RELATED DISORDERS
- A — ALIMENTARY TRACT AND METABOLISM
- AHFS Codes
- 56:28.12 — Histamine H2-antagonists
- FDA label
- Download (1.05 MB)
- MSDS
- Download (73.8 KB)
Clinical Trials
- Clinical Trials
Pharmacoeconomics
- Manufacturers
- Lupin ltd
- Navinta llc
- Salix pharmaceuticals inc
- Akorn strides llc
- Apotex inc richmond hill
- Apothecon inc div bristol myers squibb
- App pharmaceuticals llc
- Baxter healthcare corp anesthesia and critical care
- Baxter healthcare corp
- Bedford laboratories div ben venue laboratories inc
- Hospira inc
- Ben venue laboratories inc
- Claris lifesciences ltd
- Abbott laboratories
- Baxter healthcare internati0nal specialty therapies div
- Merck research laboratories div merck co inc
- L perrigo co
- Schwarz pharma inc
- Actavis elizabeth llc
- Alembic ltd
- Apotex inc
- Carlsbad technology inc
- Dr reddys laboratories ltd
- Genpharm inc
- Ivax pharmaceuticals inc sub teva pharmaceuticals usa
- Mutual pharmaceutical co inc
- Mylan pharmaceuticals inc
- Perrigo co
- Ranbaxy laboratories inc
- Sandoz inc
- Teva pharmaceuticals usa inc
- Watson laboratories inc
- Wockhardt ltd
- Wockhardt americas inc
- Packagers
- Advanced Pharmaceutical Services Inc.
- Akorn Inc.
- Amerisource Health Services Corp.
- APP Pharmaceuticals
- A-S Medication Solutions LLC
- Atlantic Biologicals Corporation
- Baxter International Inc.
- Bedford Labs
- Ben Venue Laboratories Inc.
- Bryant Ranch Prepack
- Cardinal Health
- Carlsbad Technology Inc.
- Chain Drug
- Corepharma LLC
- CVS Pharmacy
- Dispensing Solutions
- Diversified Healthcare Services Inc.
- Doctor Reddys Laboratories Ltd.
- H.J. Harkins Co. Inc.
- Heartland Repack Services LLC
- Hospira Inc.
- Ivax Pharmaceuticals
- Johnson & Johnson Healthcare
- Kaiser Foundation Hospital
- Lake Erie Medical and Surgical Supply
- Legacy Pharmaceuticals Packaging LLC
- Lupin Pharmaceuticals Inc.
- Major Pharmaceuticals
- Mckesson Corp.
- Medisca Inc.
- Merck & Co.
- Murfreesboro Pharmaceutical Nursing Supply
- Mylan
- Northstar Rx LLC
- Nucare Pharmaceuticals Inc.
- PCA LLC
- PD-Rx Pharmaceuticals Inc.
- Perrigo Co.
- Pharmaceutical Utilization Management Program VA Inc.
- Pharmedium
- Physicians Total Care Inc.
- Preferred Pharmaceuticals Inc.
- Prepackage Specialists
- Prepak Systems Inc.
- Rebel Distributors Corp.
- Redpharm Drug
- Remedy Repack
- Salix Pharmaceuticals
- Sandhills Packaging Inc.
- Southwood Pharmaceuticals
- Strides Arcolab Limited
- Teva Pharmaceutical Industries Ltd.
- UDL Laboratories
- Vangard Labs Inc.
- Walgreen Co.
- Watson Pharmaceuticals
- Wockhardt Ltd.
- Yung Shin Pharmaceutical Industry Ltd.
- Zydus Pharmaceuticals
- Dosage forms
Form Route Strength Tablet Oral 10 mg/1 Tablet, coated Oral For suspension Oral 40 mg/5mL Injection Intravenous 10 mg/1mL Injection, solution Intravenous 10 mg/1mL Injection, solution Intravenous 2 mg/1mL Powder, for solution Oral 40 mg/5mL Powder, for suspension Oral 40 mg/5mL Tablet Oral 20 mg/1 Tablet Oral 40 mg/1 Tablet, coated Oral 20 mg/1 Tablet, coated Oral 40 mg/1 Tablet, film coated Oral 10 mg/1 Tablet, film coated Oral 20 mg/1 Tablet, film coated Oral 40 mg/1 Tablet, film coated, extended release Oral 10 mg/1 Solution Intravenous 10 mg Tablet, orally disintegrating Oral 20 mg/1 Tablet, orally disintegrating Oral 40 mg/1 Injection, solution Intravenous 20 mg/50mL Injection, solution, concentrate Intravenous 10 mg/1mL Tablet Oral 10 mg Tablet, chewable Oral 20 mg/1 Tablet, chewable Oral Tablet Oral 20 mg Tablet Oral 40 mg Tablet, coated Oral 10 mg/1 - Prices
Unit description Cost Unit Pepcid 30 40 mg tablet Bottle 125.5USD bottle Pepcid 40 mg/5ml Suspension 50ml Bottle 123.88USD bottle Pepcid 30 20 mg tablet Bottle 64.13USD bottle Mylanta Double-Strength 400-400-40 mg/5ml Suspension 710ml Bottle 10.15USD bottle Mylanta 200-200-20 mg/5ml Suspension 710ml Bottle 9.23USD bottle Mylanta 200-200-20 mg/5ml Suspension 355ml Bottle 7.99USD bottle Mylanta Double-Strength 400-400-40 mg/5ml Suspension 355ml Bottle 7.99USD bottle Famotidine 40 mg tablet 3.43USD tablet Pepcid 40 mg tablet 3.02USD tablet Famotidine powder 2.74USD g Famotidine 20 mg tablet 1.76USD tablet Pepcid 20 mg tablet 1.6USD tablet Apo-Famotidine 40 mg Tablet 1.11USD tablet Mylan-Famotidine 40 mg Tablet 1.11USD tablet Novo-Famotidine 40 mg Tablet 1.11USD tablet Nu-Famotidine 40 mg Tablet 1.11USD tablet Pepcid ac 10 mg tablet 0.72USD tablet Famotidine 40 mg/4 ml vial 0.71USD ml Famotidine 500 mg/50 ml vial 0.71USD ml Apo-Famotidine 20 mg Tablet 0.62USD tablet Mylan-Famotidine 20 mg Tablet 0.62USD tablet Novo-Famotidine 20 mg Tablet 0.62USD tablet Nu-Famotidine 20 mg Tablet 0.62USD tablet Pepcid ac 20 mg tablet 0.58USD tablet Famotidine-ns 20 mg/10 ml syrg 0.54USD ml Pepcid ac 10 mg gelcap 0.48USD capsule Pepcid complete tablet chew 0.4USD tablet Famotidine 20 mg/2 ml vial 0.36USD ml Famotidine 10 mg/ml vial 0.28USD ml CVS Pharmacy acid controller 20 mg tablet 0.24USD tablet CVS Pharmacy acid controller tablet 0.24USD tablet Acid reducer 20 mg tablet 0.22USD tablet Acid controller 10 mg tablet 0.21USD tablet Mylanta gas 125 mg tablet chew 0.16USD tablet Acid reducer 10 mg tablet 0.15USD tablet Famotidine 10 mg tablet 0.15USD tablet Famotidine 20 mg piggyback 0.13USD ml Mylanta gelcap 0.12USD capsule Mylanta ultimate-strength tablet 0.07USD tablet Mylanta ultra chew tablet 0.06USD tablet Pv acid reducer 10 mg tablet 0.05USD tablet Mylanta liq 0.02USD ml Mylanta supreme antacid liq 0.02USD ml DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) US5075114 No 1991-12-24 2010-05-23 US CA2178277 No 2000-11-14 2016-06-05 Canada CA2052679 No 1997-12-02 2011-08-21 Canada US6221392 No 2001-04-24 2018-04-09 US US6024981 No 2000-02-15 2018-04-09 US US5854267 Yes 1998-12-29 2016-06-29 US US6814978 Yes 2004-11-09 2022-02-26 US US5989588 Yes 1999-11-23 2018-03-30 US US8067451 No 2011-11-29 2026-07-18 US US8501228 No 2013-08-06 2026-07-18 US US8318202 No 2012-11-27 2026-07-18 US US8449910 No 2013-05-28 2026-07-18 US US8309127 No 2012-11-13 2026-07-18 US US8067033 No 2011-11-29 2026-07-18 US US5667794 Yes 1997-09-16 2015-11-02 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 163.5 °C PhysProp water solubility 1000 mg/L (at 20 °C) MERCK INDEX (1996) logP -0.64 ISLAM,MS & NARURKAR,MM (1993) - Predicted Properties
Property Value Source Water Solubility 0.271 mg/mL ALOGPS logP -0.2 ALOGPS logP -2 ChemAxon logS -3.1 ALOGPS pKa (Strongest Acidic) 9.29 ChemAxon pKa (Strongest Basic) 8.38 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 8 ChemAxon Hydrogen Donor Count 4 ChemAxon Polar Surface Area 175.83 Å2 ChemAxon Rotatable Bond Count 6 ChemAxon Refractivity 80.46 m3·mol-1 ChemAxon Polarizability 31.66 Å3 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET features
Property Value Probability Human Intestinal Absorption + 0.9156 Blood Brain Barrier + 0.9382 Caco-2 permeable - 0.8957 P-glycoprotein substrate Non-substrate 0.5839 P-glycoprotein inhibitor I Non-inhibitor 0.9044 P-glycoprotein inhibitor II Non-inhibitor 0.8701 Renal organic cation transporter Non-inhibitor 0.6802 CYP450 2C9 substrate Non-substrate 0.7898 CYP450 2D6 substrate Non-substrate 0.9115 CYP450 3A4 substrate Non-substrate 0.7558 CYP450 1A2 substrate Non-inhibitor 0.9045 CYP450 2C9 inhibitor Non-inhibitor 0.9071 CYP450 2D6 inhibitor Non-inhibitor 0.9231 CYP450 2C19 inhibitor Non-inhibitor 0.9025 CYP450 3A4 inhibitor Non-inhibitor 0.8309 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9297 Ames test Non AMES toxic 0.5827 Carcinogenicity Non-carcinogens 0.9182 Biodegradation Not ready biodegradable 0.9324 Rat acute toxicity 1.9523 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.8366 hERG inhibition (predictor II) Inhibitor 0.6481
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Taxonomy
- Description
- This compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Azoles
- Sub Class
- Thiazoles
- Direct Parent
- 2,4-disubstituted thiazoles
- Alternative Parents
- Organic sulfuric acids and derivatives / Heteroaromatic compounds / Guanidines / Sulfenyl compounds / Propargyl-type 1,3-dipolar organic compounds / Dialkylthioethers / Azacyclic compounds / Amidines / Organopnictogen compounds / Organic oxides show 1 more
- Substituents
- 2,4-disubstituted 1,3-thiazole / Organic sulfuric acid or derivatives / Heteroaromatic compound / Guanidine / Amidine / Azacycle / Dialkylthioether / Organic 1,3-dipolar compound / Propargyl-type 1,3-dipolar organic compound / Sulfenyl compound show 9 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- sulfonamide, guanidines, 1,3-thiazole (CHEBI:4975)
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Antagonist
- General Function
- Histamine receptor activity
- Specific Function
- The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and diff...
- Gene Name
- HRH2
- Uniprot ID
- P25021
- Uniprot Name
- Histamine H2 receptor
- Molecular Weight
- 40097.65 Da
References
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
- Fukuda M, Tanaka S, Suzuki S, Kusama K, Kaneko T, Sakashita H: Cimetidine induces apoptosis of human salivary gland tumor cells. Oncol Rep. 2007 Mar;17(3):673-8. [PubMed:17273750]
- Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M: Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. Epub 2006 May 24. [PubMed:16723495]
- Kesiova M, Alexandrova A, Yordanova N, Kirkova M, Todorov S: Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues. Pharmacol Rep. 2006 Mar-Apr;58(2):221-8. [PubMed:16702624]
- Lesclous P, Schramm F, Gallina S, Baroukh B, Guez D, Saffar JL: Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats. Exp Physiol. 2006 May;91(3):561-70. Epub 2006 Mar 2. [PubMed:16513821]
- Amagase K, Okabe S: On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion. J Pharmacol Sci. 2003 Jun;92(2):124-36. [PubMed:12832840]
- Weydert JA, Ball TM, Davis MF: Systematic review of treatments for recurrent abdominal pain. Pediatrics. 2003 Jan;111(1):e1-11. [PubMed:12509588]
- Miyata K, Kamato T, Nishida A, Honda K: Studies on the mechanism for the gastric mucosal protection by famotidine in rats. Jpn J Pharmacol. 1991 Feb;55(2):211-22. [PubMed:2067140]
- Leurs R, Brozius MM, Smit MJ, Bast A, Timmerman H: Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine. Br J Pharmacol. 1991 Jan;102(1):179-85. [PubMed:1646056]
- Inan A, Sen M, Surgit O, Ergin M, Bozer M: Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo). 2009;64(6):567-70. [PubMed:19578661]
- Ojiako K, Shingala H, Schorr C, Gerber DR: Famotidine versus pantoprazole for preventing bleeding in the upper gastrointestinal tract of critically ill patients receiving mechanical ventilation. Am J Crit Care. 2008 Mar;17(2):142-7. [PubMed:18310651]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Steroid hydroxylase activity
- Specific Function
- Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
- Gene Name
- CYP2C19
- Uniprot ID
- P33261
- Uniprot Name
- Cytochrome P450 2C19
- Molecular Weight
- 55930.545 Da
References
- Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Quaternary ammonium group transmembrane transporter activity
- Specific Function
- Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creat...
- Gene Name
- SLC22A2
- Uniprot ID
- O15244
- Uniprot Name
- Solute carrier family 22 member 2
- Molecular Weight
- 62579.99 Da
References
- Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [PubMed:15496291]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- SubstrateInhibitor
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenad...
- Gene Name
- SLC22A8
- Uniprot ID
- Q8TCC7
- Uniprot Name
- Solute carrier family 22 member 8
- Molecular Weight
- 59855.585 Da
References
- Motohashi H, Uwai Y, Hiramoto K, Okuda M, Inui K: Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. [PubMed:15496291]
- Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. [PubMed:15100168]
- Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y: Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists. J Pharmacol Exp Ther. 2006 Mar;316(3):1187-94. Epub 2005 Nov 16. [PubMed:16291876]
Drug created on June 13, 2005 07:24 / Updated on February 18, 2019 20:24