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Displaying drugs 351 - 375 of 13635 in total

Dihydro-alpha-ergocryptine

Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine. Both compounds are hydrogenated ergot derivatives. Alpha-dihydroergocryptine approved drug product...
Approved
Matched Description: … These two compounds are differentiated in the position of a methyl group. ... Alpha-dihydroergocryptine approved drug product is as a part of an ergoloid mixture. ... This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine …

Vilazodone

Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain . Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Approved
Matched Description: … Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine …
Matched Categories: … Antidepressive Agents Indicated for Depression …

Golodirsen

Golodirsen is a morpholino antisense oligomer designed to treat about 8% of patients with Duchenne Muscular Dystrophy (DMD). This is an X-linked condition leading to progressive muscle degeneration that begins in early childhood, rendering many patients wheelchair-bound by age 12. Often, patients succumb to this condition by age 30 or...
Approved
Matched Description: … this drug in patients suffering from a certain form of DMD. ... [A188580,T756] A similar drug used in the treatment of other types of DMD is [eteplirsen], which targets ... a different genetic mutation. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ansuvimab

Infection with pathogenic filoviruses, such as Zaire ebolavirus (Ebola virus, EBOV), can cause severe hemorrhagic fever in humans, resulting in frequent outbreaks with case fatality rates as high as 90%.[A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development. However, to date, the most successful...
Approved
Investigational
Matched Description: … [A225933, A225938] Virtually all steps of the EBOV lifecycle have been targeted for therapeutic development ... virus disease (EVD) in the Democratic Republic of Congo during a previous outbreak that began in 2018 ... to mediate EBOV endolysosomal escape, a key step in the EBOV lifecycle. …
Matched Categories: … Antiinfectives for Systemic Use ... Treatments for Ebola Virus Disease …

Ferrous gluconate

Approved
Matched Mixtures name: … Toni Com Liq ... Alsimine W Vitamins A D ... Multi-force for Women Tab …

Ubrogepant

Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor...
Approved
Investigational
Matched Description: … Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. ... to as "gepants", have been investigated for migraines, but only ubrogepant and [rimegepant] remain in ... advance in migraine headache treatment and may become the new standard of therapy in the treatment of …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Misoprostol

Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages, prevent post partum hemorrhage, and also for first trimester abortions.[L7616,L7619,A181589,A181583,A181697] The stimulation of prostaglandin receptors in the stomach reduces gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the...
Approved
Matched Description: … , prevent post partum hemorrhage, and also for first trimester abortions. ... Misoprostol is a prostaglandin analog used to reduce the risk of NSAID related ulcers, manage miscarriages ... gastric acid secretion, while stimulating these receptors in the uterus and cervix can increase the …
Matched Categories: … Drugs for Acid Related Disorders ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …

Telmisartan

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to...
Approved
Investigational
Matched Description: … reduction in arterial blood pressure. ... causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a ... Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. …
Matched Mixtures name: … CARDIOCAP A 80/5 ... CARDIOCAP A 80/5 ... XIFEN A®80 /10 MG …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …
Matched Products: … Semintra 4mg/ml Oral Solution for Cats …

Palovarotene

Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Description: … [A244920] Palovarotene was approved for use in Canada in January 2022 for the management of heterotopic ... interest in novel treatments for this disease. ... It first garnered interest as a potential treatment for emphysema but was eventually recognized as a …

Aluminum hydroxide

Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Approved
Investigational
Matched Description: … It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. ... Subsequent increases in pH may inhibit the action of pepsin. ... An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. …
Matched Mixtures name: … Maalox oral suspension in sachet …
Matched Categories: … Drugs for Acid Related Disorders …

Ledipasvir

Ledipasvir is a direct acting antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most...
Approved
Matched Description: … In a joint recommendation published in 2016, the American Association for the Study of Liver Diseases ... being the most common in the United States, and affecting 72% of all chronic HCV patients [L852]. ... option in combination with [sofosbuvir] for the treatment of HCV genotypes 1a, 1b, 4, 5, and 6 [L852 …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Treatments for Hepatitis C ... Antivirals for treatment of HCV infections …

Meclofenamic acid

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Approved
Vet approved
Matched Description: … A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. …
Matched Categories: … Topical Products for Joint and Muscular Pain ... Antiinflammatory Preparations, Non-Steroids for Topical Use …

Dabrafenib

Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib),...
Approved
Investigational
Matched Description: … [L41955] In May 2018, Tafinlar (dabrafenib), in combination with Mekinist ([DB08911]), was approved ... Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK ... It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Patent Blue

Patent blue is aniline dye and it is one of the most common dyes used. It is a sodium or calcium salt of diethylammonium hydroxide inner salt. It has the chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cyclohexadiene-1-ylidene)diethylammonium hydroxide. Patent blue was developed by Guerbet and approved by Health Canada on December 31, 1979....
Approved
Matched Description: … [L1113] The isomer isosulphan is used in the United States for the same indications than patent blue. ... [A32573] It is a sodium or calcium salt of diethylammonium hydroxide inner salt. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Arbutamine

Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Approved
Matched Description: … Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated ... to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in ... diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Tecovirimat

The World Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in 1980. However, there have been longstanding concerns that smallpox may be used as a bioweapon.[A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002. It is effective against all orthopoxviruses,...
Approved
Investigational
Matched Description: … [A35133,L3614] Tecovirimat is an antiviral drug that was identified via a high-throughput screen in 2002 ... [A35133] It is effective against all orthopoxviruses, including vaccinia, cowpox, ectromelia, rabbitpox ... eradicated in 1980. …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …

Viloxazine

Viloxazine is a selective norepinephrine reuptake inhibitor. For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy. In the US,...
Approved
Investigational
Withdrawn
Matched Description: … Viloxazine is a selective norepinephrine reuptake inhibitor. ... [L41685] For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant ... by the FDA for the treatment of attention deficit hyperactivity disorder (ADHD). …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Monoamine Oxidase A Inhibitors …

Brilliant green cation

Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and wool. Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and swabs used to prevent infection.
Approved
Vet approved
Matched Description: … Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to ... Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic …
Matched Mixtures name: … Kerr 100 Triple Dye Dispos-A …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Eculizumab

Eculizumab is a monoclonal antibody that targets complement protein C5.[L6919,A2245] Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions.[L6919,A2245,A2246] Eculizumab was granted FDA approval on 16 March 2007. In Q1 2023, the EMA's Committee for Medicinal Products...
Approved
Investigational
Matched Description: … [L6919] In Q1 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a positive ... is used to treat a number of autoimmune conditions. ... Eculizumab is a monoclonal antibody that targets complement protein C5. …
Matched Products: … Soliris Concentrate for Solution for Infusion 300mg/vial …

Thyrotropin alfa

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of...
Approved
Vet approved
Matched Description: … Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests ... It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients ... The alpha subunit of thyrotropin alfa, which is the effector region responsible for the stimulation of …
Matched Products: … Thyrogen 0.9 mg Powder for Solution for Injection …

Brexucabtagene autoleucel

Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib and acalabrutinib, the prognosis for MCL patients remains poor and those that relapse...
Approved
Matched Description: … of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for ... method of T cell enrichment that decreases the prevalence of CD19-expressing tumour cells in the CAR ... [L15148] Brexucabtagene autoleucel was granted accelerated approval for the treatment of relapsed …

Mirabegron

Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as solifenacin and darifenacin, it lacks significant antimuscarinic activity, which is...
Approved
Matched Description: … [L32853] An extended-release granule formulation was subsequently granted approval in March 2021 for ... [L32853] Mirabegron first received FDA approval in 2012, under the brand name Myrbetriq, for the treatment ... Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of …
Matched Categories: … Drugs for Urinary Frequency and Incontinence …

Chloroprocaine

Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. The pharmacological profile of...
Approved
Investigational
Matched Description: … Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by ... methylparaben as a preservative. ... [A252952,L43382] Topical chloroprocaine for ophthalmic use was approved by the FDA in September 2022 …

Mechlorethamine

A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval for the orphan...
Approved
Investigational
Matched Description: … It was formerly used as a war gas. ... in patients who have received prior skin-directed therapy. ... The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cetuximab

Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it is responsible...
Approved
Matched Description: … [A227963] Approved by the FDA in February 2004 under the brand name ERBITUX, cetuximab is used for ... [A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis. ... [A227973] EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour …
Matched Products: … ERBITUX 5MG/ML SOLUTION FOR INFUSION …
Displaying drugs 351 - 375 of 13635 in total