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Displaying drugs 376 - 400 of 11848 in total

Ixabepilone

Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. Ixabepilone is...
Approved
Investigational
Matched Description: … Ixabepilone is a semisynthetic analogue of epothilone B. ... Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. ... It has a lactone–lactam modification that minimizes susceptibility to esterase degradation. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Mirvetuximab soravtansine

Mirvetuximab soravtansine-gynx (IMGN853) is an antibody-drug conjugate (ADC) formed by a monoclonal antibody (M9346A) that targets folate receptor alpha (FRα), covalently joined by a cleavable disulfide linker to the genotoxic compound DM4 (also known as soravtansine or ravtansine).[A254392,L43967] DM4 is conjugated to the antibody with a drug-to-antibody ratio of 3.5:1....
Approved
Investigational
Matched Description: … [A254392,L43967] DM4 is conjugated to the antibody with a drug-to-antibody ratio of 3.5:1. ... (M9346A) that targets folate receptor alpha (FRα), covalently joined by a cleavable disulfide linker ... Mirvetuximab soravtansine-gynx (IMGN853) is an antibody-drug conjugate (ADC) formed by a monoclonal antibody …

Tepotinib

Tepotinib is a MET tyrosine kinase inhibitor intended to treat a variety of MET-overexpressing solid tumors. It was originally developed in partnership between EMD Serono and the University of Texas M.D. Anderson Cancer Center in 2009 and has since been investigated in the treatment of neuroblastoma, gastric cancers, non-small cell...
Approved
Investigational
Matched Description: … Tepotinib is a MET tyrosine kinase inhibitor intended to treat a variety of MET-overexpressing solid ... [A228058] MET is a desirable target in the treatment of certain solid tumors as it appears to play a …

Coffee bean

Coffee bean allergenic extract is used in allergenic testing.
Approved

Bentonite

Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cetalkonium

Cetalkonium is a C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows it to be used in different types of formulations. It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and fungi. Cetalkonium is approved by the FDA for its use...
Approved
Matched Description: … [A27143] It is a quaternary ammonium salt that acts as an antiseptic against a variety of bacteria and ... Cetalkonium is a C16 alkyl benzalkonium chloride derivative with an amphipathic property which allows ... [L2137] Cetalkonium is approved by the FDA for its use in over-the-counter products as a skin protectant …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Bromothalonil

Bromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in many personal hygiene and industrial products. It is also a known allergen and dermatological irritant that has been banned in many EU countries due to increasing rates of contact allergy . In 2005,...
Approved
Experimental
Matched Description: … Sensitivity to Bromothalonil may be identified with a clinical patch test. ... Bromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that ... It is also a known allergen and dermatological irritant that has been banned in many EU countries due …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Simethicone

Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas bubbles to facilitate their elimination. It has a favourable safety profile as it is not systemically absorbed. Simethicone has been in use since the 1940s but was granted FDA approval in 1952.
Approved
Matched Description: … [A228308] It has a favourable safety profile as it is not systemically absorbed. ... Simethicone is a silicon based surfactant that decreases the surface tension of gastrointestinal gas …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Methylcellulose

Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3,...
Approved
Matched Description: … It is available under a variety of trade names as a treatment for constipation. ... , forming a clear viscous solution or gel. ... Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Perindopril

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to...
Approved
Matched Description: … Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor ... Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of ... ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS …

Cefradine

A semi-synthetic cephalosporin antibiotic.
Approved
Matched Description: … A semi-synthetic cephalosporin antibiotic. …

Agrostis gigantea top

Agrostis gigantea top is the flowering part of the Agrostis gigantea plant. Agrostis gigantea top is mainly used in allergenic testing.
Approved

Streptococcus pneumoniae type 10A capsular polysaccharide diphtheria CRM197 protein conjugate antigen

Streptococcus pneumoniae type 10A capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 10A individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). The saccharides...
Approved
Matched Description: … Streptococcus pneumoniae type 10A capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a ... antigens of *Streptococcus pneumoniae* serotype 10A individually conjugated to the CRM197 protein, a …

Methyltestosterone

A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US.
Approved
Matched Iupac: … ,11aS)-1-hydroxy-1,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … Methyltestosterone is a schedule III drug in the US. ... A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement …

Bepotastine

Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. Bepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co., Ltd. under the brand name Talion. It is available...
Approved
Matched Description: … Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. ... and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe Seiyaku Co …

Xanthan gum

Xanthan gum is a polysaccharide gum derived from* Xanthomonas campestris* by a pure-culture fermentation process and purified by recovery with isopropyl alcohol. The major constituents include D-glucose, D-mannose, and D-glucuronic acid. Xanthan gum is a direct food additive permitted for direct addition to food for human consumption by the FDA....
Approved
Matched Description: … Xanthan gum is a polysaccharide gum derived from* Xanthomonas campestris* by a pure-culture fermentation ... It is used as a thickening agent and stabilizer in emulsions. ... Xanthan gum is a direct food additive permitted for direct addition to food for human consumption by …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Dimercaptosuccinic acid

Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cefoxitin

Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.
Approved
Matched Description: … Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. …

Xanthium strumarium var. canadense pollen

Xanthium strumarium var. canadense pollen is the pollen of the Xanthium strumarium var. canadense plant. Xanthium strumarium var. canadense pollen is mainly used in allergenic testing.
Approved

Colchiceine

Colchiceine is one of several metabolites of the anti-gout medication colchicine.
Approved
Experimental

Brexucabtagene autoleucel

Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib and acalabrutinib, the prognosis for MCL patients remains poor and those that relapse...
Approved
Matched Description: … single-chain variable fragment (scFv) linked to internal CD28- and CD3ζ-derived co-stimulatory domains ... therapies differ in manufacturing methodology, viral vector, chimeric antigen choice, and the internal co-stimulatory ... Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified …

Azatadine

Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release.
Approved

Histrelin

Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-controlled, hydrogel polymer reservoirs containing histrelin acetate that...
Approved
Withdrawn
Matched Description: … This drug is a synthetic analog of naturally occurring GnRH with a higher potency. ... Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin …

Artesunate

Artesunate is indicated for the initial treatment of severe malaria. The World Health Organization recommends artesunate as first line treatment for severe malaria. Artesunate was developed out of a need for a more hydrophilic derivative of artemisinin. Artesunate was granted FDA approval on 26 May 2020.
Approved
Investigational
Matched Description: … [L890] Artesunate was developed out of a need for a more hydrophilic derivative of [artemisinin]. …

Latanoprostene bunod

Latanoprostene Bunod has been used in trials studying the treatment of Glaucoma, Ocular Hypertension, Open-Angle Glaucoma, Open Angle Glaucoma, and Intraocular Pressure. As of November 2, 2017 the FDA approved Bausch + Lomb's Vyzulta (latanoprostene bunod opthalmic solution), 0.024% for the indication of reducing intraocular pressure in patients with open-angle...
Approved
Investigational
Matched Iupac: … 4-(nitrooxy)butyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept …
Matched Description: … In comparison, both latanoprost and latanoprostene bunod contain a latanoprost acid backbone. …
Displaying drugs 376 - 400 of 11848 in total