Methylcellulose

Identification

Name
Methylcellulose
Accession Number
DB11228
Type
Small Molecule
Groups
Approved
Description

Methyl cellulose is a stabiliser, thickener and emulsifier for foodstuffs Different kinds of methyl cellulose can be prepared depending on the number of hydroxyl groups substituted. Cellulose is a polymer consisting of numerous linked glucose molecules, each of which exposes three hydroxyl groups. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose. The theoretical maximum is thus a DS of 3.0, however more typical values are 1.3 2.6. Methyl cellulose (or methylcellulose) is a chemical compound derived from cellulose. It is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is sold under a variety of trade names and is used as a thickener and emulsifier in various food and cosmetic products, and also as a treatment of constipation. Like cellulose, it is not digestible, not toxic, and not allergenic. Methyl cellulose belongs to the family of Dihexoses. These are disaccharides containing two hexose carbohydrates.

Synonyms
  • Cellulose methyl
  • cellulose methyl ether
  • Cellulose methylate
  • Methyl cellulose
  • methylated cellulose
  • Methylcellulose
  • Methylcellulosum
  • Metilcelulosa
External IDs
E461
Product Ingredients
IngredientUNIICASInChI Key
Methylcellulose (100 MPa.s)4GFU244C4J9004-67-5Not applicable
Methylcellulose (15 MPa.s)NPU9M2E6L89004-67-5Not applicable
Methylcellulose (1500 MPa.s)P0NTE483649004-67-5Not applicable
Methylcellulose (25 MPa.s)BI55GG2WLI9004-67-5Not applicable
Methylcellulose (400 MPa.s)O0GN6F9B2Y9004-67-5Not applicable
Methylcellulose (4000 MPa.s)MRJ667KA5E9004-67-5Not applicable
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
CitrucelTablet500 mg/1OralGlaxoSmithKline Consumer Healthcare Holdings (US) LLC2010-02-01Not applicableUs
CitrucelPowder, for solution2 g/19gOralGlaxoSmithKline Consumer Healthcare Holdings (US) LLC2010-09-16Not applicableUs
CitrucelPowder, for solution2 g/10.2gOralGlaxoSmithKline Consumer Healthcare Holdings (US) LLC2010-09-16Not applicableUs
CVS Health Soluble Fiber TherapyPowder, for solution2 g/10.2gOralCVS Health2015-09-30Not applicableUs
Entrocel Solution 1.8%Solution1.8 %OralTyco Healthcare1988-12-312010-01-07Canada
equate Fiber TherapyTablet500 mg/1OralWal-Mart Stores,Inc.,2017-08-30Not applicableUs
Fiber TherapyPowder, for solution2 g/19gOralMajor2008-04-18Not applicableUs
GNP Fiber TherapyTablet500 mg/1OralAmerisource Bergen2011-09-09Not applicableUs
Goodsense FiberTablet500 mg/1OralGoodsense2015-12-01Not applicableUs
Health Mart fiber capletsTablet500 mg/1OralMc Kesson2012-04-23Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Slim-mint GumMethylcellulose (44 mg) + Benzocaine (4 mg)Gum, chewingOralStella Pharmaceutical Canada Inc.1978-12-311998-08-13Canada
Categories
UNII
Not Available
CAS number
9004-67-5
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Clinical: Artificial tears and saliva: Solutions containing methyl cellulose or similar cellulose derivatives are used as substitute for tears or saliva if the natural production of these fluids is disturbed.

Nutritional supplement capsules : Methyl cellulose is used in the manufacture of capsules in nutritional supplements, its edible and nontoxic properties provide a vegetarian alternative to the use of gelatin.

Treatment of constipation : When eaten, methyl cellulose is not absorbed by the intestines but passes through the digestive tract undisturbed. It attracts large amounts of water into the colon, producing a softer and bulkier stool. It is used to treat constipation, diverticulosis, hemorrhoids and irritable bowel syndrome. It should be taken with sufficient amounts of fluid to prevent dehydration.

Cell culture/virology : Methyl cellulose is also used in cell culture to study viral replication. It is dissolved in the same nutrient-containing medium in which cells are normally grown. A single layer of cells are grown on a flat surface, then infected with a virus for a short time. The strength of the viral sample used will determine how many cells get infected during this time. The thick methyl cellulose medium is then added on top of the cells in place of normal liquid medium. As the viruses replicate in the infected cells, they are able to spread between cells whose membrances touch each other, but are trapped when they enter the methyl cellulose. Only cells closely neighboring an infected cell will become infected and die. This leaves small regions of dead cells called plaques in a larger background of living uninfected cells. The number of plaques formed is determined by the strength of the original sample.

Bacterial and Protozoal motility inhibitor: Aqueous methyl cellulose solutions have been used to slow bacterial and protozoal cell motility for closer inspection. Changing the amount of methyl cellulose in solution permits the adjustment of the solution's viscosity.

Stem cell differentiation : Methyl cellulose is used in the most common approaches to quantify multiple or single lineage-committed hematopoietic progenitors, called colony-forming cells (CFCs) or colony-forming units (CFUs), in combination with culture supplements that promote their proliferation and differentiation, and allow the clonal progeny of a single progenitor cell to stay together and thus form a colony of more mature cells.

Associated Conditions
Pharmacodynamics

It increases the bulk in your stool, an effect that helps to cause movement of the intestines. It also works by increasing the amount of water in the stool, making the stool softer and easier to pass.

Mechanism of action

Methylcellulose absorbs water in the gastrointestinal lumen thereby increasing the bulk of the stool. This leads to distension and stimulation of peristalsis. The ability of methylcellulose to absorb water may contribute to its efficacy in the management of diarrhea by once again increasing the bulk and consistency of the stool.

Absorption

Cellulose derivatives considered in this report are virtually unabsorbed and little or no degradation of absorbed and little or no degradation of absorbable products occurs in the human digestive tract. In humans, virtually 100 percent of orally ingested methyl cellulose can be recovered in the feces withihn four days, indicating that absorption does not occur.

Volume of distribution

accumulation in liver, spleen, lymph nodes, kidney, and vascular walls.

Protein binding
Not Available
Metabolism

Reported that when methylcellulose was given iv to dog and rabbit , aside from effect upon circulating blood, inability of body to degrade substance led to its retention & accumulation in liver, spleen, lymph nodes, kidney, and vascular walls.

Route of elimination

When swallowed they are not absorbed to any appreciable degree and appear unchanged in feces.

Half life

4.2 minutes

Clearance
Not Available
Toxicity

Organism: Mouse Test type: LD50 Route : Intraperitoneal Reported Dose: 275gm/kg ( 275000mg/kg) Toxic Effect: Details of toxic effects not reported other than lethal dose value

Organism: Mouse Test type: LDLo Route : Intravenous Reported Dose: 1gm/kg ( 1000mg/kg) Toxic Effect: Details of toxic effects not reported other than lethal dose value

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Methyl cellulose.
AclidiniumThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Agmatine.
AlcuroniumThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Alcuronium.
AlfentanilThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Alfentanil.
AlphacetylmethadolThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Alphacetylmethadol.
AlphaprodineThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Alphaprodine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Methyl cellulose.
AmiodaroneThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Amiodarone.
AmitriptylineThe therapeutic efficacy of Methyl cellulose can be decreased when used in combination with Amitriptyline.
Food Interactions
Not Available

References

General References
  1. HMDB [Link]
  2. Wikipedia [Link]
  3. FDA [Link]
  4. Toxnet [Link]
  5. ChemIDplus [Link]
  6. Webmd [Link]
External Links
KEGG Drug
D04996
PubChem Substance
347911158
ChemSpider
23107149
ChEBI
53448
Wikipedia
Methyl_cellulose
ATC Codes
A06AC06 — Methylcellulose
AHFS Codes
  • 56:12.00 — Cathartics and Laxatives
  • 52:92.00 — EENT Drugs, Miscellaneous

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceChronic Kidney Disease (CKD) / Healthy Volunteers / Test Ferric Hydroxide Adipate as Phosphate Binder in Healthy Subjects1
0WithdrawnTreatmentPain NOS / Painful musculoskeletal conditions1
1, 2CompletedTreatmentInhibition of physiological lactation therapy / Insulin Resistance / Low Milk Supply / Pre-Diabetic1
2RecruitingTreatmentCardiovascular Risk Factors / Cognitive Function 1, Social / Poor Glycemic Control1
4CompletedTreatmentIrritable Bowel Syndrome (IBS)1
4Unknown StatusTreatmentCataracts1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Powder, for solutionOral2 g/10.2g
SolutionOral1.8 %
Powder, for solutionOral2 g/19g
TabletOral500 mg/1
Solution / dropsOphthalmic10 mg/15mL
Solution / dropsOphthalmic1 %
PowderOral2 g
TabletOral500 mg
Gum, chewingOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on December 16, 2018 06:58