Methylcellulose

Identification

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Name
Methylcellulose
Accession Number
DB11228
Type
Small Molecule
Groups
Approved
Description

Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3, however more typical values are 1.3 2.6. Methyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is available under a variety of trade names as a treatment for constipation. Like cellulose, it is not digestible, not toxic, and not allergenic

Synonyms
  • Cellulose methyl
  • cellulose methyl ether
  • Cellulose methylate
  • Methyl cellulose
  • methylated cellulose
  • Methylcellulose
  • Methylcellulosum
  • Metilcelulosa
External IDs
E461
Product Ingredients
IngredientUNIICASInChI Key
Methylcellulose (100 MPa.s)4GFU244C4J9004-67-5Not applicable
Methylcellulose (15 MPa.s)NPU9M2E6L89004-67-5Not applicable
Methylcellulose (1500 MPa.s)P0NTE483649004-67-5Not applicable
Methylcellulose (25 MPa.s)BI55GG2WLI9004-67-5Not applicable
Methylcellulose (400 MPa.s)O0GN6F9B2Y9004-67-5Not applicable
Methylcellulose (4000 MPa.s)MRJ667KA5E9004-67-5Not applicable
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Best Choice Fiber TherapyTablet500 mg/1OralBest Choice (Valu Merchandisers Company)2019-04-19Not applicableUs
CDMA Fiber TherapyTablet500 mg/1OralChain Drug Marketing Association2019-04-19Not applicableUs
CitrucelPowder, for solution2 g/19gOralGlaxoSmithKline Consumer Healthcare Holdings (US) LLC2010-09-16Not applicableUs
CitrucelTablet500 mg/1OralGlaxoSmithKline Consumer Healthcare Holdings (US) LLC2010-02-01Not applicableUs
CitrucelPowder, for solution2 g/10.2gOralGlaxoSmithKline Consumer Healthcare Holdings (US) LLC2010-09-16Not applicableUs
CVS Health Soluble Fiber TherapyPowder, for solution2 g/10.2gOralCVS Health2015-09-30Not applicableUs
Entrocel Solution 1.8%SolutionOralTyco Healthcare1988-12-312010-01-07Canada
equate Fiber TherapyTablet500 mg/1OralWal-Mart Stores,Inc.,2017-08-30Not applicableUs
Fiber TherapyPowder, for solution2 g/19gOralMajor Pharmaceuticals2008-04-18Not applicableUs
GNP Fiber TherapyTablet500 mg/1OralAmerisource Bergen2011-09-09Not applicableUs
Additional Data Available
  • Application Number
    Application Number

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  • Product Code
    Product Code

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Slim-mint GumMethylcellulose (44 mg) + Benzocaine (4 mg)Gum, chewingOralStella Pharmaceutical Canada Inc.1978-12-311998-08-13Canada
Categories
UNII
Not Available
CAS number
9004-67-5

Pharmacology

Indication

Solutions containing methyl cellulose are used as substitute for tears or saliva if the natural production of these fluids is disturbed. It is also used or constipation, diverticulosis, hemorrhoids and irritable bowel syndrome. Used in the manufacture of capsules in nutritional supplements. Its edible and nontoxic properties provide a vegetarian alternative to the use of gelatin.

Associated Conditions
Pharmacodynamics

It increases the bulk in your stool, an effect that helps to cause movement of the intestines. It also works by increasing the amount of water in the stool, making the stool softer and easier to pass.

Mechanism of action

Methylcellulose absorbs water in the gastrointestinal lumen thereby increasing the bulk of the stool. This leads to distension and stimulation of peristalsis. The ability of methylcellulose to absorb water may contribute to its efficacy in the management of diarrhea by once again increasing the bulk and consistency of the stool.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Cellulose derivatives considered in this report are virtually unabsorbed and little or no degradation of absorbed and little or no degradation of absorbable products occurs in the human digestive tract. In humans, virtually 100 percent of orally ingested methyl cellulose can be recovered in the feces withihn four days, indicating that absorption does not occur.

Volume of distribution

accumulation in liver, spleen, lymph nodes, kidney, and vascular walls.

Protein binding
Not Available
Metabolism

Reported that when methylcellulose was given iv to dog and rabbit , aside from effect upon circulating blood, inability of body to degrade substance led to its retention & accumulation in liver, spleen, lymph nodes, kidney, and vascular walls.

Route of elimination

When swallowed they are not absorbed to any appreciable degree and appear unchanged in feces.

Half life

4.2 minutes

Clearance
Not Available
Toxicity

Organism: Mouse Test type: LD50 Route : Intraperitoneal Reported Dose: 275gm/kg ( 275000mg/kg) Toxic Effect: Details of toxic effects not reported other than lethal dose value

Organism: Mouse Test type: LDLo Route : Intravenous Reported Dose: 1gm/kg ( 1000mg/kg) Toxic Effect: Details of toxic effects not reported other than lethal dose value

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Methylcellulose.
AclidiniumThe therapeutic efficacy of Methylcellulose can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Methylcellulose can be decreased when used in combination with Agmatine.
AlcuroniumThe therapeutic efficacy of Methylcellulose can be decreased when used in combination with Alcuronium.
AlfentanilThe therapeutic efficacy of Methylcellulose can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Methylcellulose is combined with Alloin.
AlphacetylmethadolThe therapeutic efficacy of Methylcellulose can be decreased when used in combination with Alphacetylmethadol.
AlphaprodineThe therapeutic efficacy of Methylcellulose can be decreased when used in combination with Alphaprodine.
AmantadineThe therapeutic efficacy of Methylcellulose can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Methylcellulose.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
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  • Action
    Action

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Food Interactions
Not Available

References

General References
  1. HMDB [Link]
  2. Wikipedia [Link]
  3. FDA [Link]
  4. Toxnet [Link]
  5. ChemIDplus [Link]
  6. Webmd [Link]
External Links
KEGG Drug
D04996
PubChem Substance
347911158
ChemSpider
23107149
ChEBI
53448
Wikipedia
Methyl_cellulose
ATC Codes
A06AC06 — Methylcellulose
AHFS Codes
  • 56:12.00 — Cathartics and Laxatives
  • 52:92.00 — EENT Drugs, Miscellaneous

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceChronic Kidney Disease (CKD) / Healthy Volunteers / Test Ferric Hydroxide Adipate as Phosphate Binder in Healthy Subjects1
0WithdrawnTreatmentOrthopaedic Related Pain (Musculoskeletal Pain) / Pain1
1, 2Active Not RecruitingTreatmentCorneal Ectasia / Keratoconus1
1, 2CompletedTreatmentInhibition of physiological lactation therapy / Insulin Resistance / Low Milk Supply / Pre-Diabetic1
2Active Not RecruitingPreventionEnd-Stage Kidney Disease / Endstage Kidney Disease1
2CompletedTreatmentDry Eye1
2CompletedTreatmentProstate Cancer1
2RecruitingTreatmentAcanthamoeba Keratitis1
2RecruitingTreatmentCardiovascular Risk / Cognitive Function 1, Social / Poor Glycemic Control1
4CompletedTreatmentConjunctivitis, Seasonal Allergic2
4CompletedTreatmentDry Eye1
4CompletedTreatmentIrritable Bowel Syndrome (IBS)1
4Unknown StatusTreatmentCataracts1
4Unknown StatusTreatmentIrritable Bowel Syndrome (IBS)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Powder, for solutionOral2 g/19g
Powder, for solutionOral2 g/10.2g
SolutionOral
TabletOral500 mg/1
Solution / dropsOphthalmic10 mg/15mL
Solution / dropsOphthalmic
PowderOral
TabletOral
Gum, chewingOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on January 19, 2020 15:43