Displaying drugs 3651 - 3675 of 11853 in total
Artemisia vulgaris pollen
Artemisia vulgaris pollen is the pollen of the Artemisia vulgaris plant. Artemisia vulgaris pollen is mainly used in allergenic testing.
Approved
Ambrosia bidentata pollen
Ambrosia bidentata pollen is the pollen of the Ambrosia bidentata plant. Ambrosia bidentata pollen is mainly used in allergenic testing.
Approved
Ferrous asparto glycinate
Ferrous asparto glycinate is an iron-amino acid chelate. It is available as a dietary supplement used in the treatment of iron deficiency and iron deficiency anemia.
Approved
Matched Description: … It is available as a dietary supplement used in the treatment of iron deficiency and iron deficiency …
Betazole
A histamine H2 agonist used clinically to test gastric secretory function.
Approved
Matched Description: … A histamine H2 agonist used clinically to test gastric secretory function. …
Futibatinib
Futibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and survival. FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated FGFR signalling pathways are observed...
Approved
Investigational
Matched Description: … Futibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor ... tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and survival ... FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated …
Sufentanil
Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes.
Also known as Dsuvia, the sublingual form is used for the management of acute pain in adults that...
Approved
Investigational
Matched Description: … Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a ... This route of administration is intended to be a simple, effective, non-invasive analgesic option to …
Tenapanor
Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant irritable bowel-syndrome (IBS-C). It was first designed and synthesized in 2012. As an inhibitor of the sodium/hydrogen exchanger isoform 3 (NHE3) transporter, it is the first and currently only medication within its class[A185489,A185492,A185495] and...
Approved
Investigational
Matched Description: … first and currently only medication within its class[A185489,A185492,A185495] and therefore exists as a ... Tenapanor is a novel, small molecule medication approved in September 2019 for the treatment of constipation-predominant …
Pegvaliase
Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from Anabaena variabilis that converts phenylalanine to ammonia and trans-cinnamic acid . Both the U.S. Food and Drug Administration and European Medicines Agency approved pegvaliase-pqpz in May 2018 for the treatment of adult patients with phenylketonuria (PKU). Phenylketonuria is a...
Approved
Investigational
Matched Description: … The presence of a PEG moiety in pegvaliase-pqpz allows a reduced immune response and improved pharmacodynamic ... Pegvaliase is a recombinant phenylalanine ammonia lyase (PAL) enzyme derived from _Anabaena variabilis ... Phenylketonuria is a rare autosomal recessive disorder that is characterized by deficiency of the enzyme …
Sotorasib
Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer. This mutation makes up >50% of all KRAS mutations. Mutant KRAS discovered in 1982 but was not considered a druggable...
Approved
Investigational
Matched Description: … [A187550] Mutant KRAS discovered in 1982 but was not considered a druggable target until the mid-2010s …
Pimavanserin
Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT2A and HT2C receptors. Unlike other atypical antipsychotics, pimavanserin lacks inherent dopaminergic activity. In fact, pimavanserin is the...
Approved
Investigational
Matched Description: … [L48241,A232573] Pimavanserin was also under review as a potential treatment for dementia-related psychosis ... hallucinations and delusions associated with Parkinson's disease psychosis thanks to favorable results from a …
Panitumumab
Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent.
Panitumumab was granted FDA approval on 27 September 2006.
Approved
Investigational
Matched Description: … Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the …
Umbralisib
Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with rituximab (an anti-CD20 drug), either alone or in combination with chemotherapy. Unfortunately, many patients experience a relapse or develop resistance to these drugs. Treatment options then become limited, and alternate treatments for the lymphoma are...
Approved
Investigational
Withdrawn
Matched Description: … Unfortunately, many patients experience a relapse or develop resistance to these drugs. ... Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with ... On February 5, 2021, the Food and Drug Administration granted accelerated approval to umbralisib, a …
Triamterene
Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it acts on...
Approved
Matched Description: … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug. ... Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management ... [A177985] Since it acts on the distal nephron where only a small fraction of sodium ion reabsorption …
Amaranthus spinosus pollen
Amaranthus spinosus pollen is the pollen of the Amaranthus spinosus plant. Amaranthus spinosus pollen is mainly used in allergenic testing.
Approved
Famotidine
Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H2 receptor antagonists, famotidine displays high selectivity towards...
Approved
Matched Description: … Famotidine is a competitive histamine-2 (H2) receptor antagonist that works to inhibit gastric ... H2 receptor antagonists, famotidine displays high selectivity towards this receptor; in a ... inhibiting gastric acid secretion than [cimetidine] and eight times more potent than [ranitidine] on a …
Populus tremuloides pollen
Populus tremuloides pollen is the pollen of the Populus tremuloides plant. Populus tremuloides pollen is mainly used in allergenic testing.
Approved
Practolol
A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias.
Approved
Matched Description: … A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. …
Fosnetupitant
In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form...
Approved
Matched Description: … Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality ... Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a …
Gemifloxacin
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are...
Approved
Investigational
Matched Description: … Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment …
Lincomycin
Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium Streptomyces lincolnensis in Lincoln, Nebraska. Clinical use of lincomycin has largely been superseded by its semisynthetic derivative clindamycin due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains in use.[A190657, A190621]
Lincomycin was approved...
Approved
Vet approved
Matched Description: … Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium _Streptomyces lincolnensis ... largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a …
Siltuximab
Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). Its use is indicated for the treatment...
Approved
Investigational
Matched Description: … Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese ... It is administered as a 1 hour intravenous infusion every 3 weeks. ... MCD is a rare blood disorder caused by dysregulated IL-6 production, proliferation of lymphocytes, and …
Medicago sativa pollen
Medicago sativa pollen is the pollen of the Medicago sativa plant. Medicago sativa pollen is mainly used in allergenic testing.
Approved
Anisotropine methylbromide
Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary...
Approved
Matched Description: … Anisotropine methylbromide is a quaternary ammonium compound. ... activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a …
Ambrosia chamissonis pollen
Ambrosia chamissonis pollen is the pollen of the Ambrosia chamissonis plant. Ambrosia chamissonis pollen is mainly used in allergenic testing.
Approved
Displaying drugs 3651 - 3675 of 11853 in total