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Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury often resulting in end-stage liver failure that requires liver transplantation. Obeticholic acid is a farnesoid-X receptor (FXR) agonist used to treat this condition, possibly allowing for increased survival. In 2016, it was granted approval...
Approved
Matched Synonyms: … Obeticholic acid ... 6-ethylchenodeoxycholic acid ... 6α-ethylchenodeoxycholic acid
Matched Name: … Obeticholic acid
Matched Iupac: … 11aR)-5-ethyl-4,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid
Matched Description: … The NDA from Intercept Pharmaceuticals was approved in November 2019 and obeticholic acid is expected ... Primary biliary cirrhosis, or PBC, is a progressive and chronic condition that leads to hepatic injury ... in patients with PBC and advanced cirrhosis (e.g. those with portal hypertension or hepatic decompensation …
Matched Categories: … Bile Acid Preparations ... obeticholic acid ... Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives …
Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label] .
Approved
Matched Synonyms: … Alendronic acid ... 4-amino-1-hydroxybutane-1,1-diphosphonic acid ... (4-amino-1-hydroxybutylidene)bisphosphonic acid
Matched Name: … Alendronic acid
Matched Iupac: … (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
Matched Description: … osteoperosis and Paget's disease[FDA Label][A959,A203111]. ... Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of …
Matched Categories: … alendronic acid and colecalciferol ... alendronic acid and alfacalcidol, sequential ... alendronic acid, calcium and colecalciferol, sequential ... alendronic acid ... Drugs Affecting Bone Structure and Mineralization …
Matched Products: … ALDRONA 70 (Alendronic acid Tablets 70 mg) …
A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. [PubChem] Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid...
Approved
Matched Synonyms: … Cholic Acid
Matched Name: … Cholic Acid
Matched Iupac: … 11S,11aR)-4,7,11-trihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid
Matched Description: … A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. ... [PubChem] Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug ... Administration as a treatment for children and adults with bile acid synthesis disorders due to single …
Matched Categories: … cholic acid ... Bile Acid Preparations ... Bile Acids and Salts ... Bile and Liver Therapy ... Bile acids and derivatives …
Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography.
Approved
Withdrawn
Matched Synonyms: … Iopanoic acid ... Iodopanoic acid
Matched Name: … Iopanoic acid
Matched Iupac: … 2-[(3-amino-2,4,6-triiodophenyl)methyl]butanoic acid
Matched Description: … Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. …
Matched Categories: … iopanoic acid
An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Approved
Investigational
Nutraceutical
Matched Synonyms: … 2-ketopropionic acid ... 2-oxopropanoic acid ... Acetylformic acid
Matched Name: … Pyruvic acid
Matched Iupac: … 2-oxopropanoic acid
Matched Description: … An intermediate compound in the metabolism of carbohydrates, proteins, and fats. ... In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous …
A member of the vitamin B complex. It used to be common in sunscreening agents until found to also be a sensitizer. The potassium salt is used therapeutically in fibrotic skin disorders.
Approved
Experimental
Matched Synonyms: … Aminobenzoic acid ... 4-aminobenzoic acid ... p-Aminobenzoic acid
Matched Name: … Aminobenzoic acid
Matched Iupac: … 4-aminobenzoic acid
Matched Categories: … Emollients and Protectives ... 4-Aminobenzoic Acid ... aminobenzoic acid
Approved
Matched Synonyms: … Oxidronic acid ... Hydroxymethanediphosphonic acid ... (Hydroxymethylene)diphosphonic acid
Matched Name: … Oxidronic acid
Matched Iupac: … [hydroxy(phosphono)methyl]phosphonic acid
The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. [PubChem]
Approved
Investigational
Matched Synonyms: … Aminohippuric acid ... 4-aminohippuric acid ... p-aminohippuric acid
Matched Name: … Aminohippuric acid
Matched Iupac: … 2-[(4-aminophenyl)formamido]acetic acid
Matched Description: … The glycine amide of 4-aminobenzoic acid. ... Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory …
Matched Categories: … aminohippuric acid ... Indicators and Reagents ... Benzamides and benzamide derivatives ... Tests for Renal Function and Ureteral Injuries …
A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]
Approved
Matched Synonyms: … 5-Aminolevulinic acid ... Aminolevulinic acid ... δ-aminolevulinic acid
Matched Name: … Aminolevulinic acid
Matched Iupac: … 5-amino-4-oxopentanoic acid
Matched Description: … A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. …
Matched Salts name: … Aminolevulinic acid hydrochloride …
Matched Categories: … aminolevulinic acid ... Amino Acids, Peptides, and Proteins ... Skin and Mucous Membrane Agents ... Antineoplastic and Immunomodulating Agents …
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
Approved
Matched Synonyms: … Cromoglicic acid ... Cromoglycic acid ... 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid
Matched Name: … Cromoglicic acid
Matched Iupac: … 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid
Matched Description: … It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect …
Matched Categories: … Alimentary Tract and Metabolism ... Decongestants and Antiallergics ... reproterol and sodium cromoglicate ... salbutamol and sodium cromoglicate ... cromoglicic acid
Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to etidronic acid and clodronic acid.[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone....
Approved
Investigational
Vet approved
Matched Synonyms: … Tiludronic acid
Matched Name: … Tiludronic acid
Matched Iupac: … {[(4-chlorophenyl)sulfanyl](phosphono)methyl}phosphonic acid
Matched Description: … ] and [clodronic acid]. ... A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and ... [A202235] Tiludronic acid was granted FDA approval on 7 March 1997.[L4763] …
Matched Categories: … tiludronic acid ... Drugs Affecting Bone Structure and Mineralization …
Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. Gadoxetate is a...
Approved
Matched Synonyms: … Gadoxetic acid
Matched Name: … Gadoxetic acid
Matched Description: … Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and ... Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which ... [A263146] Gadoxetic acid, under the form gadoxetate disodium, is marketed by Bayer HealthCare Pharmaceuticals …
Matched Categories: … gadoxetic acid
Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate...
Approved
Investigational
Matched Synonyms: … dioxonitric acid
Matched Name: … Nitrous acid
Matched Iupac: … nitrous acid
Matched Description: … Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to ... applicability towards treatments for heart attacks, brain aneurysms, pulmonary hypertension in infants, and
Matched Categories: … Indicators and Reagents ... Diet, Food, and Nutrition …
Ioxitalamate is an ionic iodinated contrast medium. It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Until the...
Approved
Matched Synonyms: … Ioxitalamic acid
Matched Name: … Ioxitalamic acid
Matched Iupac: … 3-acetamido-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid
Matched Description: … [A33006] Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem ... Canada Inc and approved by Health Canada in 1995. …
Matched Categories: … ioxitalamic acid
Alpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. It is a component of many common vegetable oils and is important to human nutrition.
Approved
Investigational
Nutraceutical
Matched Synonyms: … Linolenic acid ... α-linolenic acid ... (9,12,15)-linolenic acid
Matched Name: … alpha-Linolenic acid
Matched Iupac: … (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
Matched Description: … Alpha-linolenic acid (ALA) is a polyunsaturated omega-3 fatty acid. ... It is a component of many common vegetable oils and is important to human nutrition. …
Diaminohydroxypropanetetraacetic acid has been investigated for the treatment of Vascular Disease, Coronary Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease, among others.
Approved
Investigational
Matched Synonyms: … Diaminohydroxypropanetetraacetic acid
Matched Name: … Diaminopropanol tetraacetic acid
Matched Iupac: … 2-({3-[bis(carboxymethyl)amino]-2-hydroxypropyl}(carboxymethyl)amino)acetic acid
Matched Description: … Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease, among others. ... Diaminohydroxypropanetetraacetic acid has been investigated for the treatment of Vascular Disease, Coronary …
Omega-3-acid ethyl esters are prescription drugs that contain eicosapentaenoic acid-ethyl ester (EPA) and docosahexaenoic acid-ethyl ester (DHA) that are used in combination with changes in diet to lower triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia[FDA Label] . Omega-3-acid ethyl esters are currently marketed in the US, EU,...
Approved
Investigational
Matched Synonyms: … Omega-3-acid ethyl esters ... Omega-3 fatty acid ethyl esters …
Matched Name: … Omega-3-acid ethyl esters …
Matched Description: … and docosahexaenoic acid-ethyl ester (DHA) that are used in combination with changes in diet to lower ... Omega-3-acid ethyl esters are currently marketed in the US, EU, and many other regions under the brand ... Omega-3-acid ethyl esters are prescription drugs that contain eicosapentaenoic acid-ethyl ester (EPA) …
Matched Categories: … Diet, Food, and Nutrition …
Matched Products: … Omega-3-acid Ethyl Esters ... Omega-3-Acid Ethyl Esters ... Omega-3-Acid Ethyl Ester …
Approved
Experimental
Matched Synonyms: … Testosterone enanthate benzilic acid hydrazone ... Testosterone 17-enanthate 3-benzilic acid hydrazone …
Matched Name: … Testosterone enantate benzilic acid hydrazone …
Matched Categories: … Testosterone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Sarocladium strictum allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Molds, rusts and smuts, acremonium strictum ... Molds, rusts and smuts, cephalosporium acremonium …
Matched Products: … Molds, Rusts and Smuts, Cephalosporium acremonium …
Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and light chain. Talquetamab binds to GPRC5D, a cell surface...
Approved
Investigational
Matched Synonyms: … -KAPPA/G4-LAMBDA, ANTI-(HOMO SAPIENS GPRC5D (G PROTEIN-COUPLED RECEPTOR CLASS C GROUP 5 MEMBER D)), AND ... ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY, BISPECIFIC ... ANTI-(HOMO SAPIENS CD3E (CD3 EPSILON, LEU-4)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY; BISPECIFIC …
Matched Description: … arm comprising a heavy and light chain. ... It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each ... Talquetamab binds to GPRC5D, a cell surface receptor expressed predominantly on multiple myeloma cells, and
Matched Categories: … Amino Acids, Peptides, and Proteins …
Pyrethrum is the crude extract form obtained from flowers of the plant Chrysanthemum cinerariifolium. Pyrethrin refers to a more refined extract of pyrethrum. While pyrethrum extract is composed of 6 esters, both organic compounds mediate insecticidal activities. Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species....
Approved
Matched Synonyms: … Pyrethrins and pyrethroids …
Matched Description: … Pyrethrum extract is also used used to treat head, body, and pubic lice infections. ... The active compound is absorbed by the lice and destroys them by acting on their nervous systems but …
Matched Mixtures name: … Medi and Lice Lice Killing ... Lice-Nil Lice and Eggs Killer ... Weeks and Leo Complete Lice Treatment …
Atidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A (ARSA) gene. Libmeldy was granted orphan designation by the EMA in April 2007, and was...
Approved
Matched Synonyms: … Autologous CD34+ cell enriched population that contains haematopoietic stem and progenitor cells (HSPC ... transduced with lentiviral vector which encodes for the aryl Sulfatase A complimentary deoxyribonucleic acid
Matched Description: … Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and ... [L45191] Libmeldy was granted orphan designation by the EMA in April 2007, and was issued a marketing …
Matched Categories: … Enzymes and Coenzymes ... Alimentary Tract and Metabolism …
Betula pendula pollen allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Silver birch pollen …
Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of...
Approved
Investigational
Matched Synonyms: … Coagulation factor IX, II, VII and X in combination …
Matched Description: … Coagulation factors are purified from pooled human plasma and subsequently sterilized and treated. ... For example, Kcentra (FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) ... include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs...
Approved
Matched Synonyms: … D and C Yellow No. 7 …
Matched Description: … and corneal trauma. ... It has been approved by FDA for use in externally applied drugs and cosmetics. ... A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline …
Matched Mixtures name: … Minims Lidocaine and Fluorescein ... Fluorescein Sodium and Proparacaine Hydrochloride ... Fluorescein Sodium and Benoxinate Hydrochloride …
Matched Categories: … Indicators and Reagents …
Displaying drugs 26 - 50 of 14945 in total