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Displaying drugs 51 - 75 of 77 in total

Somatrem

Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disposition of short...
Approved
Investigational
Withdrawn
Matched Description: … Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... Somatropin and Somatropin Agonists ... Anterior Pituitary Lobe Hormones and Analogues …

Trastuzumab

Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal...
Approved
Investigational
Matched Description: … Trastuzumab binds to HER2 and suppresses cancer cell growth, proliferation, and survival directly and ... [L14015] It is used as a treatment of human epidermal growth factor receptor (HER)-2+ metastatic breast ... selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human …
Matched Categories: … HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors ... Amino Acids, Peptides, and Proteins ... pertuzumab and trastuzumab ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …

Xylose

Xylose is a monosaccharide of the aldopentose type consisted of five carbon atoms and an aldehyde functional group. Xylose is a sugar isolated from wood. D-Xylose is a sugar widely used as a diabetic sweetener in food and beverage. Xylose has also been used as a diagnostic agent to observe...
Approved
Matched Description: … D-Xylose is a sugar widely used as a diabetic sweetener in food and beverage. ... Xylose is a monosaccharide of the aldopentose type consisted of five carbon atoms and an aldehyde functional ... immediately - but its metabolism results in a variety of substrates that can serve important nutritional and …

Dapagliflozin

Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tubule of the nephron...
Approved
Matched Description: … [A6757] Dapagliflozin has been investigated either as monotherapy or as an adjunct treatment with insulin ... Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor ... by inhibiting glucose reabsorption in the proximal tubule of the nephron and causing glycosuria. …
Matched Mixtures name: … Dapagliflozin and Metformin Hydrochloride ... Dapagliflozin and Metformin Hydrochloride …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and dapagliflozin ... saxagliptin and dapagliflozin ... metformin, saxagliptin and dapagliflozin …

Levothyroxine

Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the...
Approved
Matched Description: … a ratio of T4 to T3 of 4.2:1, which is significantly lower than the 14:1 ratio of secretion by the human ... produce sufficient quantities of the thyroid hormones T4 (tetraiodothyronine or thyroxine) and ... hypothyroidism begin to develop such as fatigue, increased heart rate, depression[A179620], dry skin and …
Matched Mixtures name: … Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid ... Levothyroxine and Liothyronine Thyroid …
Matched Categories: … Sex Hormones and Insulins ... Amino Acids, Peptides, and Proteins ... levothyroxine sodium and iodine compounds ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Insulin-like growth factor II

The insulin-like growth factor II is a well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. This factor presents effects related to growth regulation, insulin-like and mitogenic activities. To perform its biological activities, this growth factor can present some dependence to somatotropin. It...
Experimental
Matched Synonyms: … Human insulin-like growth factor II ... Insulin-like growth factor II (human) ... Human oligopeptide-24 …
Matched Name: … Insulin-like growth factor II …
Matched Description: … This factor presents effects related to growth regulation, insulin-like and mitogenic activities. ... the liver and to circulate in the blood. ... The insulin-like growth factor II is a well-characterized neutral peptide believed to be secreted by …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

Recombinant human insulin-like growth factor 1

Investigational
Matched Name: … Recombinant human insulin-like growth factor 1 …

Proinsulin human

Investigational
Matched Synonyms: … Proinsulin human ... Proinsulin biosynthetic human ... Proinsulin recombinant human …
Matched Name: … Proinsulin human …
Matched Categories: … Insulin ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Pegylated synthetic human c-peptide

Investigational
Matched Synonyms: … Pegylated human c-peptide …
Matched Name: … Pegylated synthetic human c-peptide …
Matched Categories: … Insulin ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Tralesinidase alfa

Tralesinidase alfa is a chimeric fusion protein comprised of recombinant human NAGLU and a modified human insulin-like growth factor 2. It is being investigated for the treatment of mucopolysaccharidosis type IIIB (MPS IIIB), also known as Sanfilippo syndrome B.
Investigational
Matched Synonyms: … Recombinant human NAGLU-insulin-like growth factor II ... Recombinant human alpha-N-acetylglucosaminidase-insulin-like growth factor-2 ... Alpha-N-acetyglucosaminidase-insulin-like-growth-factor-2 fusion protein …
Matched Description: … Tralesinidase alfa is a chimeric fusion protein comprised of recombinant human NAGLU and a modified human ... insulin-like growth factor 2. …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

C-peptide

C-peptide is under investigation in clinical trial NCT00278980 (Effect of C-peptide on Diabetic Peripheral Neuropathy).
Investigational
Matched Synonyms: … Insulin c-peptide ... Human c-peptide ... Human proinsulin c-peptide …
Matched Categories: … Insulin ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

AGT-182

AGT-182 is an investigational enzyme replacement therapy engineered by the fusion of the iduronate-2-sulfatase (IDS) enzyme and a human insulin receptor monoclonal antibody.
Investigational
Matched Synonyms: … Recombinant human insulin receptor monoclonal antibody-fused iduronate 2-sulfatase …
Matched Description: … a human insulin receptor monoclonal antibody. ... investigational enzyme replacement therapy engineered by the fusion of the iduronate-2-sulfatase (IDS) enzyme and …

Reveglucosidase alfa

Investigational
Matched Synonyms: … Des-(2-7)-human insulin-like growth factor ii fusion protein with glycyl-l-alanyl-l-prolyl-human lysosomal …

Ersodetug

Investigational
Matched Synonyms: … Immunoglobulin G2, anti-(human insulin receptor) (human monoclonal RZ358 γ2-chain), disulfide with human ... immunoglobulin G2-kappa, anti-[Homo sapiens INSR (insulin receptor)], Homo sapiens monoclonal antibody …

Kisspeptin-10

Kisspeptin-10 is under investigation in clinical trial NCT03771326 (KP-10 and Insulin Secretion in Men).
Investigational
Matched Synonyms: … Human metastin 45-54 ... Kisspeptin-10 (human) …
Matched Description: … Kisspeptin-10 is under investigation in clinical trial NCT03771326 (KP-10 and Insulin Secretion in Men …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Intercellular Signaling Peptides and Proteins …

rhGAD65

rhGAD65 (recombinant human glutamic acid decarboxylase) is a vaccine being developed to treat insulin dependent type 1 diabetes.
Investigational
Matched Synonyms: … Recombinant human GAD65 ... Recombinant human glutamate decarboxylase 2 ... Recombinant human glutamic acid decarboxylase …
Matched Description: … rhGAD65 (recombinant human glutamic acid decarboxylase) is a vaccine being developed to treat insulin …

NN344

NN344 is a neutral, soluble long-acting human insulin analogue with 24 hour coverage by once daily injection. NN344 has a very flat and predictable action profile. The product is intended for basal insulin treatment of diabetes mellitus.
Investigational
Matched Description: … NN344 is a neutral, soluble long-acting human insulin analogue with 24 hour coverage by once daily injection ... NN344 has a very flat and predictable action profile. ... The product is intended for basal insulin treatment of diabetes mellitus. …
Matched Categories: … Insulin ... Insulin, Long-Acting ... Amino Acids, Peptides, and Proteins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

rhIGFBP-3

rhIGFBP-3 (recombinant human insulin-like growth factor binding protein-3) is Insmed’s proprietary anti-cancer compound that has demonstrated significant decreases in cancerous growth in several models of human. It is developed by Insmed and is currently under phase I of the clinical trial.
Investigational
Matched Description: … rhIGFBP-3 (recombinant human insulin-like growth factor binding protein-3) is Insmed’s proprietary anti-cancer ... It is developed by Insmed and is currently under phase I of the clinical trial. ... compound that has demonstrated significant decreases in cancerous growth in several models of human. …

Cixutumumab

Cixutumumab has been used in trials studying the treatment of Lung Cancer, Malignant Neoplasm, Leukemia, Mast-Cell, Non-Small-Cell Lung Carcinoma, and Adenocarcinoma of the Prostate. Cixutumumab is a highly specific recombinant human monoclonal antibody with high affinity for the insulin-like growth factor-I receptor (IGF-IR). IGF-IR is overexpressed in a variety of...
Investigational
Matched Description: … Cixutumumab is a highly specific recombinant human monoclonal antibody with high affinity for the insulin-like ... the treatment of Lung Cancer, Malignant Neoplasm, Leukemia, Mast-Cell, Non-Small-Cell Lung Carcinoma, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Chromic citrate

Experimental

XL228

XL228 is a novel anticancer compound designed to inhibit the insulin-like growth factor type-1 receptor (IGF1R), Src and Abl tyrosine kinases – targets that play crucial roles in cancer cell proliferation, survival and metastasis.
Investigational
Matched Description: … , survival and metastasis. ... XL228 is a novel anticancer compound designed to inhibit the insulin-like growth factor type-1 receptor ... (IGF1R), Src and Abl tyrosine kinases – targets that play crucial roles in cancer cell proliferation …

Linsitinib

An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. IGF-1R inhibitor OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis.
Investigational
Matched Description: … An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) ... OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and …

INCB13739

INCB13739 is developed as a new treatment for type 2 diabetes. It is an orally available small molecule inhibitor of 11beta-HSD1 (11-beta hydroxysteroid dehydrogenase type 1). 11beta-HSD1 is an enzyme that appears to be critical to the development of type 2 diabetes.
Investigational

ATL1101

ATL1101 is a second-generation antisense drug designed to block the synthesis of the IGF-1 receptor, a protein involved in the regulation of cell overgrowth in psoriasis. ATL1101 is being developed as a cream for the topical treatment of mild to moderate cases of psoriasis.
Investigational

Genistein

An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, genistein has antihelmintic activity. It has been...
Investigational
Matched Description: … Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. ... It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is ... used as an antineoplastic and antitumor agent. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …
Displaying drugs 51 - 75 of 77 in total