This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
- Pharmacological action
- General Function:
- Protein tyrosine kinase activity
- Specific Function:
- Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation,...
- Gene Name:
- Uniprot ID:
- Uniprot Name:
- Insulin-like growth factor 1 receptor
- Molecular Weight:
- 154791.73 Da
Drug created on October 20, 2016 15:43 / Updated on June 08, 2017 09:40