Advanced Filter

Filter by Group

Filter by Market Availability

Displaying drugs 76 - 100 of 14053 in total
Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a vaccine.
Approved
Matched Name: … Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen …
Matched Description: … a vaccine. ... Neisseria meningitidis group a capsular oligosaccharide diphtheria crm197 protein conjugate antigen is …
Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene (βA-T87Q-globin) to hematopoietic stem cells in order to treat β-thalassemia. β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a significant decrease in the production of β-globin. This affects...
Approved
Investigational
Matched Synonyms: … Autologous CD34+ cells encoding βA-T87Q-Globin gene
Matched Description: … [L42940] β-thalassemia is a condition caused by mutations in the β-globin gene (HBB) that leads to a ... [A251770,A251785] Betibeglogene autotemcel was approved by the FDA in August 2022 and is the first ex-vivo ... lentiviral vector gene therapy available in the U.S. for the treatment of people with β-thalassemia. …
Matched Categories: … Autologous Hematopoietic Stem Cell-Based Gene Therapy …
Tofersen is under an intrathecally administered antisense oligonucleotide targeting the mutated SOD1 gene that causes amyotrophic lateral sclerosis (ALS). Although there were various causes of ALS, 2% of ALS cases are due to SOD1 mutations, with more than 200 SOD1 mutations documented.[A259028,A259033] Tofersen was granted accelerated approval from the FDA...
Approved
Investigational
Matched Synonyms: … Antisense Oligonucleotide Inhibitor Of The Expression Of Superoxide Dismutase 1 Gene ... METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-SP-T-SP-A-SP-M5C-SP-A-SP-T-SP-T-SP-T-SP-M5C-SP-T-SP-A-SP …
Matched Description: … gene that causes amyotrophic lateral sclerosis (ALS). ... Tofersen is under an intrathecally administered antisense oligonucleotide targeting the mutated SOD1 ... accelerated approval from the FDA on April 25, 2023, as the first treatment for adults with ALS caused by
Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. It binds to androgen receptors with high affinity. By competing with androgens for binding to androgen receptors, clascoterone works by blocking the androgen receptor signalling cascades that promote acne pathogenesis, such as sebaceous gland proliferation, excess sebum production, and...
Approved
Investigational
Matched Synonyms: … 11-deoxycortisol 17α-propionate …
Matched Iupac: … hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Description: … [A218771] By competing with androgens for binding to androgen receptors, clascoterone works by blocking ... [A218846] In August 2020, FDA approved clascoterone for the first-in-class topical treatment of acne ... Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. …
Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine is used to prevent invasive meningococcal disease, which is caused by bacteria Neisseria meningitidis entering the bloodstream and invading the blood-brain barrier to cause a variety of infections such as septicemia, meningitis, and pneumonia. Several serogroups of N....
Approved
Matched Name: … Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine …
Matched Description: … , marketed as MENVEO, was first approved by the FDA in 2010. ... _ CRM197 protein carrier, resulting in four drug substances contained in each dose of vaccine. ... to prevent invasive meningococcal disease, which is caused by bacteria _Neisseria meningitidis_ entering …
Voretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy. An adeno-associated virus is a small virus that infects humans and other primates. It is not pathogenic and it causes a very mild immune response. This type of virus is vastly used as vectors for gene therapy because they can...
Approved
Matched Synonyms: … Recombinant adeno-associated virus retinal pigment epithelium gene vector AAV2-hRPE65v2 …
Matched Description: … capacity by the removal of *rep* and *cap* and the insertion of the desired gene with its promoter between ... specific region of the human cellular genome localized in the chromosome 19. ... It is not pathogenic and it causes a very mild immune response. …
Approved
Matched Synonyms: … 11-deoxycorticosterone acetate …
Matched Iupac: … 9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.
Approved
Matched Synonyms: … (monomethoxypolyethylene glycol succinimidyl) 11-17-adenosine deaminase …
Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels...
Approved
Vet approved
Matched Synonyms: … Luteinizing hormone-releasing factor (pig), 6-D-tryptophan …
Matched Iupac: … (2S)-N-[(2S)-5-carbamimidamido-1-[(2S)-2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl]-1-oxopentan-2-yl ... ]-2-[(2R)-2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-4-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl …
Matched Description: … Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH) ... Serum testosterone concentrations may fall to levels typically observed in surgically castrated men. ... After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production …
Matched Products: … Triptofem 0,1 mg/ml Injektionslösung in einer Fertigspritze ... Decapeptyl Depot - Retardmikrokapseln und Suspensionsmittel in Einmalspritzen …
Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK...
Approved
Investigational
Matched Synonyms: … 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3- …
Matched Iupac: … 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-5H,6H,11H-benzo[b]carbazole-3-carbonitrile …
Matched Description: … Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma ... Approved under accelerated approval in 2015, alectinib is indicated for use in patients who have progressed ... It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through...
Approved
Investigational
Vet approved
Matched Synonyms: … D-Glucose in linear form …
Matched Description: … a basic health system. ... L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. ... Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and …
Matched Mixtures name: … Acd-A ... Anticoagulant Citrate Dextrose A ACD-A ... Acd A
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … DEXTROSE 5% IN DIS.WATER INJ 500ML ... DEXTROSE 5% IN DIS.WATER INJ 1000ML ... 5% GLUCOSE INJ JP IN 20ML PLASTIC AMP …
Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the...
Approved
Matched Synonyms: … Neovitamin A acid ... 13-cis-Vitamin A acid …
Matched Description: … Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne. ... the iPLEDGE program in the United States. ... [L6574] Isotretinoin is associated with major risks in pregnancy and is therefore only available under …
Matched Categories: … Retinoids for Topical Use in Acne …
Matched Products: … ISOFACE 5 MG ... Ciscutan 5 mg - Kapseln ... ORATANE CAPSULE 5 mg …
Interferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
Approved
Matched Synonyms: … Intron A ... Intron A (Interferon α2b) …
Matched Description: … A type I interferon consisting of 165 amino acid residues with arginine in position 23. ... This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes …
Matched Mixtures name: … Intron A ... Intron A ... Intron A - Kit (pws+diluent) 3000000iu/vial …
Matched Products: … INTRON A SOLUCION INYECTABLE (HS.A. FREE) 5 MUI ... Intron A ... Intron A - Liq 5000000iu/ml …
Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high...
Approved
Matched Synonyms: … 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol …
Matched Description: … Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used ... in schizophrenia, major depression, and bipolar disorder. ... [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …
Matched Categories: … Serotonin 5-HT1 Receptor Antagonists ... Serotonin 5-HT2 Receptor Antagonists ... Serotonin 5-HT1A Receptor Antagonists ... Serotonin 5-HT2A Receptor Antagonists …
Matched Products: … QUETIAPINA SANDOZ A/S …
Glatiramer acetate is a mix of synthetic polypeptides that includes L-glutamic acid, L-alanine, L-tyrosine, and L-lysine at an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. Since glatiramer acetate is a heterogeneous drug, there is limited information about its physicochemical properties. Originally, glatiramer acetate was designed as a...
Approved
Investigational
Matched Synonyms: … (T,G)-A-L …
Matched Description: … [A248880] It was approved by the FDA in 1996, and a generic version became available in 2017. ... immunomodulatory effects and reduces the relapse rate of relapsing-remitting multiple sclerosis (RRMS) by ... [A248870] Originally, glatiramer acetate was designed as a stimulant of myelin basic protein (MBP), a
Matched Products: … Copaxone 20 mg/ml Injektionslösung in einer Fertigspritze ... Copaxone 40 mg/ml Injektionslösung in einer Fertigspritze ... Copaxobene 20 mg/ml Injektionslösung in einer Fertigspritze …
Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus Beauveria nivea. Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now available in various products...
Approved
Investigational
Vet approved
Matched Synonyms: … Cyclosporin A
Matched Description: … [A174049] Initially manufactured by Sandoz and approved for use by the FDA in 1983, cyclosporine is now ... available in various products by Novartis (previously known as Sandoz). ... Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Matched Products: … Cyclosporine A ... Nail Cyclosporin-A ... MODUSIK-A OFTENO …
Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a rare bleeding disorder, exogenous replacement of this key coagulation factor is essential...
Approved
Matched Synonyms: … Factor XIII A-Subunit (Recombinant) ... Coagulation Factor XIII A-Subunit (recombinant) ... Blood Coagulation Factor XIII (Synthetic Human A-Chain Precursor) …
Matched Description: … As the half-life of endogenous Factor XIII is long (5-11 days), prophylactic therapy with the replacement ... When activated by thrombin at the site of injury, the FXIII A2B2 pro-enzyme is cleaved resulting in activation ... It is subsequently isolated by homogenization of cells and purification by several chromatography steps …
Nadofaragene firadenovec (nadofaragene firadenovec-vncg) is a recombinant non-replicating adenovirus serotype 5 vector containing a transgene encoding human interferon alfa-2b (IFNα2b). It was approved by the FDA on December 2022 for the treatment of high-risk Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without...
Approved
Investigational
Matched Synonyms: … alpha-2b) gene under the control of the cytomegalovirus (cmv) immediate-early enhancer/promoter ... Replication-deficient adenovirus type 5 (ad5) vector encoding the human interferon alpha 2 (ifna2, interferon …
Matched Description: … serotype 5 vector containing a transgene encoding human interferon alfa-2b (IFNα2b). ... It is the first gene therapy approved by the FDA for the treatment of bladder cancer. ... The localized expression of this gene induces anti-tumor effects. …
Matched Categories: … Cellular and Gene Therapy ... Antineoplastic cell and gene therapy …
Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
Approved
Investigational
Matched Synonyms: … Factor VIII (rDNA) …
Matched Description: … Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by
Matched Categories: … Hemophilia A
Matched Products: … ADVATE 3000 IU/5 ML IV ENJEKSIYON ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET ... ADVATE 250 IU/5 ML IV ENJEKSIYON ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET ... ADVATE 500 IU/5 ML IV ENJEKSIYON ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET …
Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making up 80%, 6%, and 14% respectively all of which are obtained from the soil bacterial species Bacillus brevis and called collectively gramicidin D. Gramcidins are 15 residue peptides with alternating D and L amino...
Approved
Matched Synonyms: … Gramicidin A
Matched Description: … topical antibiotic and is also found in Polysporin ophthalmic solution. ... Gramcidin D is a heterogeneous mixture of three antibiotic compounds, gramicidins A, B and C, making ... amino acids, which assemble inside of the hydrophobic interior of the cellular lipid bilayer to form a
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Synonyms: … 6-O-methylerythromycin A
Matched Iupac: … 4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5- …
Matched Description: … synthesis by binding to the bacterial 50S ribosomal subunit. ... Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein …
Matched Products: … ROLICYTIN® 250 MG/5 ML POLVO PARA RECONSTITUIR A SUSPENSION ORAL ... MACROMYCIN GRÁNULOS PARA RECONSTITUIR A SUSPENSIÓN ORAL ... CLARITROMICINA 250MG/5ML GRANULOS PARA RECONSTITUIR A SUSPENSION ORAL. …
Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination.
Approved
Matched Synonyms: … 5,6,7,8-Tetrahydro-3-(2-(4-(o-tolyl)-1-piperazinyl)ethyl)-s-triazolo(4,3-a)pyridine …
Matched Iupac: … 1-(2-methylphenyl)-4-(2-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)piperazine …
Matched Description: … It is found in ophthalmic solutions used to reverse mydriasis after an eye examination. …
Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78...
Approved
Matched Synonyms: … FSH-a
Matched Description: … Follitropin is important in the development of follicles produced by the ovaries. ... Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to ... However, a more recent study showed there is may be a slight clinical difference, with the alpha form …
Matched Mixtures name: … MENOGON 75 IU LIYOFILIZE TOZ ICEREN AMPUL,5 ADET ... MENOPUR 150 IU IM VE SC ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 5 ADET ... MENOPUR 75 IU IM VE SC ENJEKSIYON ICIN TOZ ICEREN FLAKON, 5 ADET …
Matched Products: … REKOVELLE SOLUTION FOR INJECTION IN A PRE-FILLED PEN 12MCG/0.36ML ... REKOVELLE SOLUTION FOR INJECTION IN A PRE-FILLED PEN 72MCG/2.16ML ... REKOVELLE SOLUTION FOR INJECTION IN A PRE-FILLED PEN 36MCG/1.08ML …
Meningococcal group W-135 polysaccharide is group-specific polysaccharide antigens extracted and purified from Neisseria meningitidis serogroup W-135. N. meningitidis is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia. It is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup W-135.
Approved
Experimental
Investigational
Matched Synonyms: … Neisseria meningitidis group W-135 polysaccharide antigen, A
Matched Description: … subcutaneously administered as an active immunization against the invasive meningococcal disease caused by ... *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia …
Matched Mixtures name: … MENACTRA 0,5 ML IM ENJEKSİYONLUK ÇÖZELTİ İÇEREN FLAKON, 5 ADET ... Menomune-A/c/y/w-135 ... Menomune-A/c/y/w-135 …
Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of...
Approved
Investigational
Matched Synonyms: … Coagulation factor IX, II, VII and X in combination …
Matched Description: … Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting ... factors found in functioning human plasma. ... Complex is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by
Displaying drugs 76 - 100 of 14053 in total