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Displaying drugs 1 - 25 of 621 in total

Olaratumab

Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Studies show that the...
Approved
Investigational
Matched Description: … reduction of cancer cell proliferation and tumor growth. ... It is composed of two heavy chain molecule fragments and 2 light chain fragments. ... fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of …

Pralatrexate

Pralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma . Pralatrexate was developed in response due to the inferior responses of patients using the standard therapy for their B-cells counterparts. Compared to methotrexate, pralatrexate has better accumulation in cancer cells. Pralatrexate is designed to have...
Approved
Investigational
Matched Description: … Pralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma ... Pralatrexate was developed in response due to the inferior responses of patients using the standard therapy ... [L37674] It is also being studied for other types of lymphoma and solid malignancy such as non-small-cell …

Guanoxan

Guanoxan is an antihypertensive agent similar in its mechanism of action to guanethidine; may cause liver damage. Guanoxan was approved in the UK but was withdrawn from the market due to hepatotoxicity.
Approved
Matched Description: … Guanoxan is an antihypertensive agent similar in its mechanism of action to guanethidine; may cause liver …

Azelaic acid

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin. Azelaic acid is effective against a number of skin conditions, such...
Approved
Matched Description: … Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis ... topically in a cream formulation of 20%. ... It is also produced by _Malassezia furfur_, also known as _Pityrosporum ovale_, which is a species of …
Matched Products: … Azclear Action Medicated Lotion …

Ceritinib

Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy. About 4% of patients with NSCLC have a chromosomal rearrangement that generates a fusion gene between EML4 (echinoderm microtubule-associated protein-like...
Approved
Matched Description: … of the downstream signaling protein STAT3, and proliferation of ALK-dependent cancer cells. ... Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic ... non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior …

Pimozide

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994,...
Approved
Matched Description: … Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has ... that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of …

Lithium carbonate

Lithium has been used to treat manic episodes since the 19th century . Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Approved
Matched Description: … Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651, …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Tranexamic acid

Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Approved
Matched Description: … It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent ... prevention of major bleeding. ... Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and …

Metaxalone

Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous system depression. Metaxalone...
Approved
Matched Description: … Its main mechanism of action is thought to involve general central nervous system depression. ... Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Cetylpyridinium

Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic properties. Its salt form, cetylpyridinium chloride, is typically found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. In these products, it generally mediates an antiseptic activity and protective action against dental plaque and reducing gingivitis.
Approved
Matched Description: … In these products, it generally mediates an antiseptic activity and protective action against dental …
Matched Mixtures name: … GOLA ACTION ... GOLA ACTION ... GOLA ACTION …
Matched Products: … Multi-Action Antiseptic ... Shopko Alcohol Free Multi Action ... Equaline Multi-Action Antiseptic …

Lenvatinib

Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progression in addition to their normal cellular...
Approved
Investigational
Matched Description: … and increased expression of VEGF is associated with a poor prognosis in many types of cancers. ... Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular ... receptor tyrosine kinases (RTKs) located in the cell membrane play a central role in the activation of …

Diethylpropion

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
Approved
Illicit
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Praziquantel

Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 drug cost to treat...
Approved
Investigational
Vet approved
Matched Description: … [A263206,A263211] Despite being approved since 1980, the exact mechanism of action is yet to be elucidated ... Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis ... [A263201] The efficacy of praziquantel in treating parasitic flatworms infection with low cost (~US$0.20 …

Paliperidone

Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin...
Approved
Matched Description: … The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. ... the other effects of the drug. ... Paliperidone is the primary active metabolite of risperidone. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Nefazodone

Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with...
Approved
Withdrawn
Matched Description: … On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States. ... Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) ... Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Diloxanide furoate

Approved

Flibanserin

Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder...
Approved
Investigational
Matched Description: … Flibanserin's mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, ... It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of ... displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Modafinil

Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated...
Approved
Investigational
Matched Description: … The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake ... Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides ... used in the treatment of narcolepsy. …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Eugenol

Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide for root canal sealing and pain control. Although not currently available in any FDA-approved...
Approved
Matched Description: … Its exact mechanism of action is unknown, however, it has been shown to interfere with action potential ... the treatment of toothache. ... There are a number of unapproved OTC products available containing eugenol that advertise its use for …

Tislelizumab

Tislelizumab is a humanized monoclonal IgG4 antibody against programmed death receptor-1 (PD-1). It was engineered to have a nullified Fc portion, thus minimizing binding to FcγR on macrophages and limiting treatment resistance via antibody-dependent phagocytosis. By blocking PD-L1/PD-L2–mediated cell signaling, tislelizumab restores T-cell function through cytokine production, resulting in immune-mediated...
Approved
Investigational

Dimethyl fumarate

Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor...
Approved
Investigational
Matched Description: … [A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood ... Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis. ... [A253917] Prior to its FDA approval, dimethyl fumarate had been used in Germany for treatment of psoriasis …

Benzydamine

Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system. Although the indazole analogue benzydamine is a...
Approved
Matched Description: … traditional aspirin-like NSAIDs but facilitate benzydamine's mechanism of action as an effective locally-acting ... it has various physicochemical properties and pharmacologic activities that are different from those of ... It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal …
Matched Mixtures name: … GOLA ACTION ... GOLA ACTION ... GOLA ACTION …

Glymidine

Glycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin. The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta...
Approved
Investigational
Matched Description: … The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating ... the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral ... and increasing the sensitivity of peripheral tissues to insulin. …
Matched Categories: … combinations of sulfonamides …

Risdiplam

Risdiplam is an orally bioavailable mRNA splicing modifier used for the treatment of spinal muscular atrophy (SMA). It increases systemic SMN protein concentrations by improving the efficiency of SMN2 gene transcription. This mechanism of action is similar to its predecessor nusinersen, the biggest difference being their route of administration: nusinersen...
Approved
Investigational
Matched Description: … This mechanism of action is similar to its predecessor [nusinersen], the biggest difference being their ... [onasemnogene abeparvovec], whereas risdiplam offers the ease of oral bioavailability. ... Risdiplam is an orally bioavailable mRNA splicing modifier used for the treatment of spinal muscular …
Matched Categories: … Survival of Motor Neuron 2 Splicing Modifier …

Amantadine

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and...
Approved
Matched Description: … in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake. ... An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. ... The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Displaying drugs 1 - 25 of 621 in total