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Identification
NameModafinil
Accession NumberDB00745  (APRD00534)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionModafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
Structure
Thumb
Synonyms
Modafinil
Modafinilo
Modafinilum
Moderateafinil
Provigil
External Identifiers
  • CEP 1538
  • CRL 40476
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AlertecTablet100 mgOralTeva Canada Limited1999-03-24Not applicableCanada
Auro-modafinilTablet100 mgOralAuro Pharma Inc2014-10-24Not applicableCanada
Bio-modafinilTablet100 mgOralBiomed Pharma2015-10-06Not applicableCanada
Ipg-modafinilTablet100 mgOralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-modafinilTablet100 mgOralMarcan Pharmaceuticals Inc2015-01-09Not applicableCanada
ModafinilTablet100 mg/1OralCima Labs Inc.2012-03-29Not applicableUs
ModafinilTablet200 mg/1OralAphena Pharma Solutions Tennessee, Llc2012-03-29Not applicableUs
ModafinilTablet200 mg/1OralCima Labs Inc.2012-03-29Not applicableUs
ModafinilTablet100 mg/1OralPar Pharmaceutical2012-04-06Not applicableUs
ModafinilTablet200 mg/1OralAphena Pharma Solutions Tennessee, Llc2012-04-06Not applicableUs
ModafinilTablet200 mg/1OralDispensing Solutions, Inc.2012-03-29Not applicableUs
ModafinilTablet200 mg/1OralPar Pharmaceutical2012-04-06Not applicableUs
ModafinilTablet200 mg/1OralSTAT Rx USA LLC2012-04-06Not applicableUs
ProvigilTablet200 mg/1OralUnit Dose Services1998-12-24Not applicableUs
ProvigilTablet100 mg/1OralRebel Distributors Corp2005-06-03Not applicableUs
ProvigilTablet200 mg/1Oralbryant ranch prepack1998-12-24Not applicableUs
ProvigilTablet100 mg/1OralPhysicians Total Care, Inc.2005-06-03Not applicableUs
ProvigilTablet200 mg/1OralRebel Distributors Corp2004-01-19Not applicableUs
ProvigilTablet100 mg/1Oralbryant ranch prepack1998-12-24Not applicableUs
ProvigilTablet200 mg/1OralPhysicians Total Care, Inc.2004-01-19Not applicableUs
ProvigilTablet200 mg/1OralLake Erie Medical Surgical & Supply DBA Quality Care Products LLC2011-07-20Not applicableUs
ProvigilTablet100 mg/1OralCephalon, Incorporated1999-02-15Not applicableUs
ProvigilTablet100 mg/1OralCardinal Health1998-12-24Not applicableUs
ProvigilTablet200 mg/1OralCephalon, Incorporated1999-02-15Not applicableUs
Teva-modafinilTablet100 mgOralTeva Canada Limited2014-07-02Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-modafinilTablet100 mgOralApotex Inc2008-05-01Not applicableCanada
ModafinilTablet200 mg/1OralAv Kare, Inc.2014-02-24Not applicableUs
ModafinilTablet100 mg/1OralAmerican Health Packaging2014-04-01Not applicableUs
ModafinilTablet100 mg/1OralMylan Pharmaceuticals Inc.2012-08-10Not applicableUs
ModafinilTablet200 mg/1OralHikma Pharmaceutical2008-04-04Not applicableUs
ModafinilTablet200 mg/1OralApotex Corp.2014-02-03Not applicableUs
ModafinilTablet100 mg/1OralMylan Institutional Inc.2012-09-06Not applicableUs
ModafinilTablet200 mg/1OralQualitest Pharmaceuticals2013-01-292017-06-30Us
ModafinilTablet100 mg/1OralOrchid Pharma Inc2013-08-01Not applicableUs
ModafinilTablet200 mg/1Oralbryant ranch prepack2013-04-03Not applicableUs
ModafinilTablet200 mg/1OralAlembic Pharmaceuticals Inc.2016-05-20Not applicableUs
ModafinilTablet200 mg/1OralAphena Pharma Solutions Tennessee, Llc2012-08-10Not applicableUs
ModafinilTablet200 mg/1OralAmerican Health Packaging2014-04-01Not applicableUs
ModafinilTablet200 mg/1OralMylan Pharmaceuticals Inc.2012-08-10Not applicableUs
ModafinilTablet100 mg/1OralHikma Pharmaceutical2008-04-04Not applicableUs
ModafinilTablet100 mg/1OralAv Pak2016-08-01Not applicableUs
ModafinilTablet200 mg/1OralMylan Institutional Inc.2012-09-06Not applicableUs
ModafinilTablet100 mg/1OralMajor Pharmaceuticals2013-04-03Not applicableUs
ModafinilTablet200 mg/1OralOrchid Pharma Inc2013-08-01Not applicableUs
ModafinilTablet100 mg/1OralAurobindo Pharma Limited2012-09-27Not applicableUs
ModafinilTablet100 mg/1OralIngenus Pharmaceuticals, LLC2014-04-01Not applicableUs
ModafinilTablet100 mg/1OralGolden State Medical Supply, Inc.2014-02-03Not applicableUs
ModafinilTablet200 mg/1OralAv Pak2016-08-01Not applicableUs
ModafinilTablet100 mg/1OralActavis Pharma, Inc.2013-04-03Not applicableUs
ModafinilTablet100 mg/1OralCitron Pharma LLC2012-09-27Not applicableUs
ModafinilTablet200 mg/1OralMajor Pharmaceuticals2013-04-03Not applicableUs
ModafinilTablet100 mg/1OralAv Kare, Inc.2014-02-24Not applicableUs
ModafinilTablet200 mg/1OralAurobindo Pharma Limited2012-09-27Not applicableUs
ModafinilTablet200 mg/1OralIngenus Pharmaceuticals, LLC2014-04-01Not applicableUs
ModafinilTablet100 mg/1OralQualitest Pharmaceuticals2013-01-292017-06-30Us
ModafinilTablet200 mg/1OralActavis Pharma, Inc.2013-04-03Not applicableUs
ModafinilTablet200 mg/1OralGolden State Medical Supply, Inc.2014-02-03Not applicableUs
ModafinilTablet100 mg/1OralAlembic Pharmaceuticals Inc.2016-05-20Not applicableUs
ModafinilTablet200 mg/1OralCitron Pharma LLC2012-09-27Not applicableUs
ModafinilTablet100 mg/1OralApotex Corp.2014-02-03Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AlertexSaval
AspendosMedochemie
ForcilinLKM
MentixRoyal Pharma
ModasomilCephalon
ModavigilCSL
ModiodalCephalon
ProvakeRanbaxy
ResotylDrugtech
SparlonCephalon
StavigileLibbs
VigicerBeta
VigilCephalon
ZaluxNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIR3UK8X3U3D
CAS number68693-11-8
WeightAverage: 273.35
Monoisotopic: 273.082349419
Chemical FormulaC15H15NO2S
InChI KeyYFGHCGITMMYXAQ-UHFFFAOYSA-N
InChI
InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
IUPAC Name
2-diphenylmethanesulfinylacetamide
SMILES
NC(=O)CS(=O)C(C1=CC=CC=C1)C1=CC=CC=C1
Pharmacology
IndicationTo improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
Structured Indications
PharmacodynamicsModafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. Modafinil is not indicated for complaints of lack of energy or fatigue; but it appears to be very helpful for some patients. Also, it has been used in the treatment of hypersomnia, a disorder in which patients lack the capacity for meaningful sleep and may require ten or more hours per day. Recent studies have have found that modafinil may help recovering cocaine addicts fight their addiction.
Mechanism of actionThe exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors.
TargetKindPharmacological actionActionsOrganismUniProt ID
Sodium-dependent dopamine transporterProteinyes
inhibitor
HumanQ01959 details
Alpha-1B adrenergic receptorProteinunknown
partial agonist
HumanP35368 details
Related Articles
AbsorptionRapid following oral administration.
Volume of distribution
  • 0.9 L/kg
Protein binding60%
Metabolism

Hepatic

SubstrateEnzymesProduct
Modafinil
modafinil acidDetails
Route of eliminationThe major route of elimination is metabolism (~90%), primarily by the liver, with subsequent renal elimination of the metabolites.
Half life23-215 hours
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Catechol O-methyltransferase
Gene symbol: COMT
UniProt: P21964
rs4680 Not AvailableAA allelePoor response to modafinil19037200
Catechol O-methyltransferase
Gene symbol: COMT
UniProt: P21964
rs4680 Not AvailableGG alleleThose with the GG genotype respond better to drug therapy (improved vigor and well being). Those with the AA genotype do not respond well to drug therapy19037200
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Modafinil.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Modafinil.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Modafinil.Approved
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Modafinil.Approved
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Modafinil.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Modafinil.Approved
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Modafinil.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Modafinil.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Modafinil.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Modafinil.Approved
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Modafinil.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Modafinil.Approved
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Modafinil.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Modafinil.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Modafinil.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Modafinil.Approved
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Modafinil.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Modafinil.Approved
AmiodaroneThe metabolism of Modafinil can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Modafinil.Approved
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Modafinil.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Modafinil.Approved, Vet Approved
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Modafinil.Approved
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Modafinil.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Modafinil.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Modafinil.Approved, Investigational
AprepitantThe serum concentration of Modafinil can be increased when it is combined with Aprepitant.Approved, Investigational
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Modafinil.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Modafinil.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Modafinil.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be decreased when it is combined with Modafinil.Approved
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Modafinil.Approved
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Modafinil.Approved, Withdrawn
AtazanavirThe metabolism of Modafinil can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Modafinil can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Modafinil.Approved
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Modafinil.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Modafinil.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Modafinil.Approved
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Modafinil.Approved
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Modafinil.Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Modafinil.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Modafinil.Approved
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Modafinil.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Modafinil.Approved
BexaroteneThe serum concentration of Modafinil can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Modafinil.Approved
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Modafinil.Approved
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Modafinil.Approved
BoceprevirThe metabolism of Modafinil can be decreased when combined with Boceprevir.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Modafinil.Approved, Investigational
BosentanThe serum concentration of Modafinil can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Modafinil.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Modafinil.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Modafinil.Approved
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Modafinil.Approved
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Modafinil.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Modafinil.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Modafinil.Approved
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Modafinil.Approved
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Modafinil.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Modafinil.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Modafinil.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Modafinil.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Modafinil.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Modafinil.Approved
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Modafinil.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Modafinil.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Modafinil.Approved
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Modafinil.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Modafinil.Approved
CarbamazepineThe metabolism of Modafinil can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Modafinil.Approved
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Modafinil.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Modafinil.Approved
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Modafinil.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Modafinil.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Modafinil.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Modafinil.Approved, Vet Approved
CeritinibThe serum concentration of Modafinil can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Modafinil.Withdrawn
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Modafinil.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Modafinil.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Modafinil.Approved, Vet Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Modafinil.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Modafinil.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Modafinil.Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Modafinil.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Modafinil.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Modafinil.Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Modafinil.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Modafinil.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Modafinil.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Modafinil.Approved
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Modafinil.Approved
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Modafinil.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Modafinil.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Modafinil.Approved
ClemastineThe metabolism of Modafinil can be decreased when combined with Clemastine.Approved
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Modafinil.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Modafinil.Approved, Illicit
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Modafinil.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Modafinil.Approved
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Modafinil.Investigational
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Modafinil.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Modafinil.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Modafinil.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Modafinil resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Modafinil.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Modafinil.Approved, Illicit
ClotrimazoleThe metabolism of Modafinil can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Modafinil.Approved
CobicistatThe metabolism of Modafinil can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Modafinil.Approved
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Modafinil.Approved, Illicit
CodeineThe serum concentration of Codeine can be decreased when it is combined with Modafinil.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Modafinil.Approved
ConivaptanThe serum concentration of Modafinil can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Modafinil.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Modafinil.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Modafinil.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Modafinil.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Modafinil.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Modafinil.Approved, Investigational
DabrafenibThe serum concentration of Modafinil can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Modafinil.Approved
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Modafinil.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Modafinil.Approved
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Modafinil.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Modafinil.Approved, Investigational
DarunavirThe metabolism of Modafinil can be decreased when combined with Darunavir.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Modafinil.Approved
DasatinibThe serum concentration of Modafinil can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Modafinil.Approved
DeferasiroxThe serum concentration of Modafinil can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Modafinil.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Modafinil.Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Modafinil.Approved
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Modafinil.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Modafinil.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Modafinil.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Modafinil.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Modafinil.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Modafinil.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Modafinil.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Modafinil.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Modafinil.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Modafinil.Approved
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Modafinil.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Modafinil.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Modafinil.Approved
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Modafinil.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Modafinil.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Modafinil.Approved
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Modafinil.Approved
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Modafinil.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Modafinil.Approved
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Modafinil.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Modafinil.Approved
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Modafinil.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Modafinil.Approved, Investigational
DoxycyclineThe metabolism of Modafinil can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Modafinil.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Modafinil.Approved
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Modafinil.Approved, Investigational
EfavirenzThe serum concentration of Modafinil can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Modafinil.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Modafinil.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Modafinil.Approved
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Modafinil.Approved, Vet Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Modafinil.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Modafinil.Approved
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Modafinil.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Modafinil.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Modafinil.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Modafinil.Approved
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Modafinil.Approved
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Modafinil.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Modafinil.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Modafinil.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Modafinil.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Modafinil can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Modafinil.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Modafinil.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Modafinil.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Modafinil.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Modafinil.Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Modafinil.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Modafinil.Approved
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Modafinil.Approved
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Modafinil.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Modafinil.Approved
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Modafinil.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Modafinil.Approved, Illicit
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Modafinil.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Modafinil.Approved
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Modafinil.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Modafinil.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Modafinil.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Modafinil.Approved, Investigational
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Modafinil.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Modafinil.Approved
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Modafinil.Approved
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Modafinil.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Modafinil.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Modafinil.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Modafinil.Approved
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Modafinil.Approved
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Modafinil.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Modafinil.Approved
FluconazoleThe metabolism of Modafinil can be decreased when combined with Fluconazole.Approved
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Modafinil.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Modafinil.Approved, Illicit
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Modafinil.Approved
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Modafinil.Approved, Vet Approved
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Modafinil.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Modafinil.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Modafinil.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Modafinil.Approved
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Modafinil.Approved
FluvoxamineThe metabolism of Modafinil can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Modafinil.Approved, Investigational
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Modafinil.Approved
FosaprepitantThe serum concentration of Modafinil can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Modafinil can be increased when combined with Fosphenytoin.Approved
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Modafinil.Approved, Investigational
Fusidic AcidThe serum concentration of Modafinil can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Modafinil.Approved
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Modafinil.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be decreased when it is combined with Modafinil.Approved
GliclazideThe metabolism of Gliclazide can be decreased when combined with Modafinil.Approved
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Modafinil.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Modafinil.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Modafinil.Approved
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Modafinil.Approved, Investigational
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Modafinil.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Modafinil.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Modafinil.Approved
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Modafinil.Approved
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Modafinil.Approved, Vet Approved
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Modafinil.Withdrawn
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Modafinil.Approved
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Modafinil.Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Modafinil.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Modafinil.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Modafinil.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Modafinil.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Modafinil.Approved
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Modafinil.Approved
IdelalisibThe serum concentration of Modafinil can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Modafinil resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Modafinil.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Modafinil.Approved
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Modafinil.Approved
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Modafinil.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Modafinil.Approved
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Modafinil.Approved
IndinavirThe metabolism of Modafinil can be decreased when combined with Indinavir.Approved
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Modafinil.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Modafinil.Approved
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Modafinil.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be decreased when it is combined with Modafinil.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Modafinil.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Modafinil.Approved
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Modafinil.Approved
ItraconazoleThe metabolism of Modafinil can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Modafinil.Approved
IvacaftorThe serum concentration of Modafinil can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Modafinil.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Modafinil.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Modafinil.Approved
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Modafinil.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Modafinil.Approved
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Modafinil.Approved
KetoconazoleThe metabolism of Modafinil can be decreased when combined with Ketoconazole.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Modafinil.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Modafinil.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Modafinil.Investigational
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Modafinil.Approved
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Modafinil.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Modafinil.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Modafinil.Approved
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Modafinil.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Modafinil.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Modafinil.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Modafinil.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Modafinil.Approved
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Modafinil.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Modafinil.Approved
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Modafinil.Approved
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Modafinil.Approved
LopinavirThe metabolism of Modafinil can be decreased when combined with Lopinavir.Approved
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Modafinil.Approved
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Modafinil.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Modafinil.Approved
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Modafinil.Approved, Investigational
LuliconazoleThe serum concentration of Modafinil can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Modafinil can be increased when combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Modafinil.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Modafinil.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Modafinil.Approved
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Modafinil.Approved
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Modafinil.Approved, Investigational
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Modafinil.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Modafinil.Approved, Investigational
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Modafinil.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Modafinil.Approved, Nutraceutical, Vet Approved
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Modafinil.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Modafinil.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Modafinil.Approved, Illicit
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Modafinil.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Modafinil.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Modafinil.Experimental
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Modafinil.Illicit, Withdrawn
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Modafinil.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Modafinil.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Modafinil.Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Modafinil.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Modafinil.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Modafinil.Approved
MetoprololThe metabolism of Metoprolol can be decreased when combined with Modafinil.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Modafinil.Approved
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Modafinil.Approved
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Modafinil.Approved
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Modafinil.Withdrawn
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Modafinil.Approved, Illicit
MifepristoneThe serum concentration of Modafinil can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Modafinil.Approved
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Modafinil.Approved
MitotaneThe serum concentration of Modafinil can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Modafinil.Approved
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Modafinil.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Modafinil.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Modafinil.Approved, Investigational
NafcillinThe serum concentration of Modafinil can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Modafinil.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Modafinil.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Modafinil.Approved, Investigational
NefazodoneThe metabolism of Modafinil can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Modafinil can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Modafinil can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Modafinil can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Modafinil.Approved
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Modafinil.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Modafinil.Approved
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Modafinil.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Modafinil.Approved
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Modafinil.Approved
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Modafinil.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Modafinil.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Modafinil.Approved
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Modafinil.Approved
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Modafinil.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Modafinil.Approved
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Modafinil.Approved
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Modafinil.Approved
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Modafinil.Approved
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Modafinil.Approved
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Modafinil.Approved
OsimertinibThe serum concentration of Modafinil can be increased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Modafinil.Approved
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Modafinil.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Modafinil.Approved
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Modafinil.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Modafinil.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Modafinil.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Modafinil.Approved
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Modafinil.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Modafinil.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Modafinil.Approved
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Modafinil.Approved
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Modafinil.Approved
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Modafinil.Approved
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Modafinil.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Modafinil.Approved
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Modafinil.Approved
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Modafinil.Approved
PentobarbitalThe metabolism of Modafinil can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Modafinil.Approved
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Modafinil.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Modafinil.Approved
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Modafinil.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Modafinil.Approved
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Modafinil.Approved
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Modafinil.Withdrawn
PhenobarbitalThe metabolism of Modafinil can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Modafinil.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Modafinil.Approved
PhenytoinThe metabolism of Modafinil can be increased when combined with Phenytoin.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Modafinil.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Modafinil.Approved, Investigational
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Modafinil.Approved
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Modafinil.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Modafinil.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Modafinil.Approved
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Modafinil.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Modafinil.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Modafinil.Approved
PosaconazoleThe metabolism of Modafinil can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be decreased when it is combined with Modafinil.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Modafinil.Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Modafinil.Approved
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Modafinil.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Modafinil.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Modafinil.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Modafinil.Approved, Vet Approved
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Modafinil.Approved
PrimidoneThe metabolism of Modafinil can be increased when combined with Primidone.Approved, Vet Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Modafinil.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Modafinil.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Modafinil.Approved
PromazineThe serum concentration of Promazine can be decreased when it is combined with Modafinil.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Modafinil.Approved
PropofolThe serum concentration of Propofol can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Modafinil.Approved, Investigational
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Modafinil.Approved
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Modafinil.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Modafinil.Approved
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Modafinil.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Modafinil.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Modafinil.Approved
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Modafinil.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Modafinil.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Modafinil.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Modafinil.Approved
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Modafinil.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Modafinil.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Modafinil.Approved
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Modafinil.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Modafinil.Approved
RifabutinThe metabolism of Modafinil can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Modafinil can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Modafinil can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Modafinil.Approved
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Modafinil.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Modafinil.Approved
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Modafinil.Approved, Investigational
RitonavirThe metabolism of Modafinil can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Modafinil.Approved
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Modafinil.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Modafinil.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Modafinil.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Modafinil.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Modafinil.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Modafinil.Approved
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Modafinil.Approved
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Modafinil.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Modafinil.Approved
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Modafinil.Approved
SaquinavirThe metabolism of Modafinil can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Modafinil.Approved
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Modafinil.Approved
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Modafinil.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Modafinil.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Modafinil.Approved
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Modafinil.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Modafinil.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Modafinil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Modafinil.Approved
SiltuximabThe serum concentration of Modafinil can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Modafinil.Approved
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Modafinil.Approved
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Modafinil.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Modafinil.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Modafinil.Approved
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Modafinil.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Modafinil.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Modafinil.Approved, Investigational
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Modafinil.Approved
St. John's WortThe serum concentration of Modafinil can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Modafinil can be increased when it is combined with Stiripentol.Approved
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Modafinil.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Modafinil.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Modafinil.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Modafinil.Approved
SulfisoxazoleThe metabolism of Modafinil can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Modafinil.Approved, Investigational
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Modafinil.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Modafinil.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Modafinil.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Modafinil.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Modafinil.Approved
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Modafinil.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Modafinil.Approved
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Modafinil.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Modafinil.Experimental
TelaprevirThe metabolism of Modafinil can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Modafinil can be decreased when combined with Telithromycin.Approved
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Modafinil.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Modafinil.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Modafinil.Approved
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Modafinil.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Modafinil.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Modafinil.Investigational
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Modafinil.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Modafinil.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Modafinil.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Modafinil.Approved
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Modafinil.Approved
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Modafinil.Approved
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Modafinil.Approved
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Modafinil.Approved
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Modafinil.Approved
TimololThe metabolism of Timolol can be decreased when combined with Modafinil.Approved
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Modafinil.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Modafinil.Approved
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Modafinil.Approved, Investigational
TocilizumabThe serum concentration of Modafinil can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Modafinil.Approved, Investigational
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Modafinil.Approved
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Modafinil.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Modafinil.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Modafinil.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Modafinil.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Modafinil.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Modafinil.Approved
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Modafinil.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Modafinil.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Modafinil.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Modafinil.Approved
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Modafinil.Approved
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Modafinil.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Modafinil.Approved
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Modafinil.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Modafinil.Approved
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Modafinil.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Modafinil.Approved
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Modafinil.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Modafinil.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Modafinil.Approved
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Modafinil.Investigational
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Modafinil.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Modafinil.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Modafinil.Approved
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Modafinil.Approved
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Modafinil.Approved
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Modafinil.Investigational
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Modafinil.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Modafinil.Approved
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Modafinil.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Modafinil.Approved, Investigational
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Modafinil.Approved
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Modafinil.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Modafinil.Approved
VoriconazoleThe metabolism of Modafinil can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Modafinil.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Modafinil.Approved
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Modafinil.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Modafinil.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Modafinil.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Modafinil.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Modafinil.Approved
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Modafinil.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Modafinil.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Modafinil.Approved
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Modafinil.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Modafinil.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Modafinil.Approved
Food Interactions
  • Take without regard to meals.
References
Synthesis Reference

DrugSyn.org

US4177290
General References
  1. Lindsay SE, Gudelsky GA, Heaton PC: Use of modafinil for the treatment of attention deficit/hyperactivity disorder. Ann Pharmacother. 2006 Oct;40(10):1829-33. Epub 2006 Sep 5. [PubMed:16954326 ]
  2. Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A: Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett. 2003 Mar 20;339(2):143-6. [PubMed:12614915 ]
External Links
ATC CodesN06BA07
AHFS Codes
  • 28:20.92
PDB EntriesNot Available
FDA labelDownload (98.9 KB)
MSDSDownload (57 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9947
Caco-2 permeable+0.5066
P-glycoprotein substrateNon-substrate0.8912
P-glycoprotein inhibitor INon-inhibitor0.8842
P-glycoprotein inhibitor IINon-inhibitor0.9962
Renal organic cation transporterNon-inhibitor0.8153
CYP450 2C9 substrateNon-substrate0.793
CYP450 2D6 substrateNon-substrate0.8659
CYP450 3A4 substrateNon-substrate0.5971
CYP450 1A2 substrateNon-inhibitor0.6653
CYP450 2C9 inhibitorNon-inhibitor0.6045
CYP450 2D6 inhibitorNon-inhibitor0.9117
CYP450 2C19 inhibitorNon-inhibitor0.6952
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6395
Ames testNon AMES toxic0.6562
CarcinogenicityNon-carcinogens0.6665
BiodegradationReady biodegradable0.6304
Rat acute toxicity2.0926 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9799
hERG inhibition (predictor II)Non-inhibitor0.9279
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Cephalon inc
  • Cephalon, Inc.
Packagers
Dosage forms
FormRouteStrength
TabletOral100 mg
TabletOral100 mg/1
TabletOral200 mg/1
Prices
Unit descriptionCostUnit
Provigil 200 mg tablet15.33USD tablet
Provigil 100 mg tablet13.58USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2165824 No2005-08-022014-06-14Canada
CA2201967 No2002-12-102015-10-04Canada
US7297346 Yes2004-05-292024-05-29Us
USRE37516 No1994-10-062014-10-06Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point164-166 °CNot Available
water solubilitySlightly solubleNot Available
logP0.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.622 mg/mLALOGPS
logP1.75ALOGPS
logP1.53ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)8.84ChemAxon
pKa (Strongest Basic)-4.4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.16 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity77.39 m3·mol-1ChemAxon
Polarizability28.71 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylmethanes
Direct ParentDiphenylmethanes
Alternative Parents
Substituents
  • Diphenylmethane
  • Sulfoxide
  • Primary carboxylic acid amide
  • Carboxamide group
  • Sulfinyl compound
  • Carboxylic acid derivative
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Monoamine transmembrane transporter activity
Specific Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Gene Name:
SLC6A3
Uniprot ID:
Q01959
Molecular Weight:
68494.255 Da
References
  1. Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP: Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization. J Med Chem. 2004 Nov 18;47(24):5821-4. [PubMed:15537337 ]
  2. Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ: Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther. 2006 Nov;319(2):561-9. Epub 2006 Aug 2. [PubMed:16885432 ]
  3. Swanson JM: Role of executive function in ADHD. J Clin Psychiatry. 2003;64 Suppl 14:35-9. [PubMed:14658934 ]
  4. Dopheide MM, Morgan RE, Rodvelt KR, Schachtman TR, Miller DK: Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants. Eur J Pharmacol. 2007 Jul 30;568(1-3):112-23. Epub 2007 Apr 5. [PubMed:17477916 ]
  5. Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM: Dopaminergic role in stimulant-induced wakefulness. J Neurosci. 2001 Mar 1;21(5):1787-94. [PubMed:11222668 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
partial agonist
General Function:
Protein heterodimerization activity
Specific Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Gene Name:
ADRA1B
Uniprot ID:
P35368
Molecular Weight:
56835.375 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chen CR, Qu WM, Qiu MH, Xu XH, Yao MH, Urade Y, Huang ZL: Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice. Neuropharmacology. 2007 Sep;53(4):534-41. Epub 2007 Jun 30. [PubMed:17681557 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Robertson P Jr, Hellriegel ET: Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet. 2003;42(2):123-37. [PubMed:12537513 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on December 04, 2016 03:59