Inhibition of theophylline clearance by troleandomycin.

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Weinberger M, Hudgel D, Spector S, Chidsey C

Inhibition of theophylline clearance by troleandomycin.

J Allergy Clin Immunol. 1977 Mar;59(3):228-31.

PubMed ID

300083 [ View in PubMed

]

Abstract

The effect of troleandomycin, a macrolide antibiotic, on theophylline elimination was examined in eight patients with chronic asthma. Clearance from serum was reduced by 50 +/- 6% (mean +/- SD) during administration of 250 mg troleandomycin four times daily. Reduction of clearance persisted to a lesser degree in one of these patients examined while receiving 250 mg troleandomycin daily. An increase in serum theophylline concentration can thus result from initiating troleandomycin in asthmatic patients receiving continuous treatment with theophylline. This may be at least a partial explanation for the apparent benefit of troleandomycin in chronic asthma and also suggests that possibility of inducing theophylline toxicity, including seizures, as was observed in one of the patients in this study.

DrugBank Data that Cites this Article

Drugs

Troleandomycin

Drug Interactions

Drugs	Interaction
Integrate drug-drug interactions in your software
Aminophylline Tylvalosin	The metabolism of Aminophylline can be decreased when combined with Tylvalosin.
Aminophylline Josamycin	The metabolism of Aminophylline can be decreased when combined with Josamycin.
Aminophylline Sirolimus	The metabolism of Aminophylline can be decreased when combined with Sirolimus.
Aminophylline Everolimus	The metabolism of Aminophylline can be decreased when combined with Everolimus.
Aminophylline Temsirolimus	The metabolism of Aminophylline can be decreased when combined with Temsirolimus.