Triptans.

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Nicolas S, Nicolas D

Triptans.

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PubMed ID

32119394 [ View in PubMed

]

Abstract

Triptans are a class of medications used in the treatment of migraine headaches. Triptans act as antimigraine agents by selectively binding to the serotonin receptors 5-HT1B and 5-HT1D. Triptan binding to the vascular 5-HT1B receptors leads to vasoconstriction of the cranial arteries, which painfully dilate during a migraine attack. This activity reviews the indications, action, and contraindications for triptans as valuable agents in migraine therapy and also highlights the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for the management team members of patients with migraine.

DrugBank Data that Cites this Article

Drugs

Rizatriptan

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
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Rizatriptan Seproxetine	The risk or severity of serotonin syndrome can be increased when Seproxetine is combined with Rizatriptan.
Rizatriptan Citalopram	The risk or severity of serotonin syndrome can be increased when Citalopram is combined with Rizatriptan.
Rizatriptan Zimelidine	The risk or severity of serotonin syndrome can be increased when Zimelidine is combined with Rizatriptan.
Rizatriptan Sertraline	The risk or severity of serotonin syndrome can be increased when Sertraline is combined with Rizatriptan.
Rizatriptan Dapoxetine	The risk or severity of serotonin syndrome can be increased when Dapoxetine is combined with Rizatriptan.