Synthesis of a novel fluorescent probe for estrogen receptor.

Article Details

Citation

Copy to clipboard

Adamczyk M, Reddy RE, Yu Z

Synthesis of a novel fluorescent probe for estrogen receptor.

Bioorg Med Chem Lett. 2002 May 6;12(9):1283-5.

PubMed ID

11965371 [ View in PubMed

]

Abstract

A novel estradiol-mimetic fluorescent probe 5 was synthesized from diethylstilbestrol (DES, 1), which is useful for probing estrogen receptor (ERalpha), a prognostic indicator of estrogen-dependent cancers, and for developing a homogeneous fluorescence polarization (FP) assay to identify the ligands of estrogen receptor.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Diethylstilbestrol	Estrogen receptor alpha	IC 50 (nM)	0.33	N/A	N/A	Details
Estradiol	Estrogen receptor alpha	IC 50 (nM)	3.4	N/A	N/A	Details
Tamoxifen	Estrogen receptor alpha	IC 50 (nM)	8.4	N/A	N/A	Details