Practical management of adverse events associated with cabozantinib treatment in patients with renal-cell carcinoma.
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Gerendash BS, Creel PA
Practical management of adverse events associated with cabozantinib treatment in patients with renal-cell carcinoma.
Onco Targets Ther. 2017 Oct 19;10:5053-5064. doi: 10.2147/OTT.S145295. eCollection 2017.
- PubMed ID
- 29089775 [ View in PubMed]
- Abstract
Cabozantinib is an oral tyrosine-kinase inhibitor whose targets include VEGFR, MET, and AXL. Cabozantinib is approved for the treatment of patients with advanced clear-cell renal-cell carcinoma (RCC) who have received prior antiangiogenic therapy. In the pivotal Phase III trial of second-line RCC, cabozantinib was associated with a significant improvement in overall survival, progression-free survival, and antitumor response compared with everolimus. Adverse events (AEs) were common for patients receiving cabozantinib, but were effectively managed with supportive care and dose modifications, as discontinuations of cabozantinib due to an AE were infrequent. This article reviews the management of the more common AEs associated with cabozantinib based on findings from the pivotal study, clinical practice guidelines, and the authors' real-world clinical experience, with support from published literature. We focus on hypertension, palmar-plantar erythrodysesthesia, diarrhea, nausea, vomiting, decreased appetite, fatigue, and stomatitis. Effective management of these AEs involves a multimodal strategy that includes patient education, prophylactic and supportive care, and dose modifications. Effective AE management can allow patients to maintain antitumor activity with cabozantinib while mitigating the impact on quality of life.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Cabozantinib Cytochrome P450 3A4 Protein Humans NoSubstrateDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareCabozantinibAmiodarone The metabolism of Cabozantinib can be decreased when combined with Amiodarone. CabozantinibDelavirdine The metabolism of Cabozantinib can be decreased when combined with Delavirdine. CabozantinibMethimazole The metabolism of Cabozantinib can be decreased when combined with Methimazole. CabozantinibMidostaurin The metabolism of Cabozantinib can be decreased when combined with Midostaurin. CabozantinibRitonavir The metabolism of Cabozantinib can be decreased when combined with Ritonavir.