Solute carrier organic anion transporter family member 2B1
Details
- Name
- Solute carrier organic anion transporter family member 2B1
- Synonyms
- KIAA0880
- OATP-B
- OATP-RP2
- OATP2B1
- OATPB
- OATPRP2
- Organic anion transporter B
- Organic anion transporter polypeptide-related protein 2
- SLC21A9
- Solute carrier family 21 member 9
- Gene Name
- SLCO2B1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037115|Solute carrier organic anion transporter family member 2B1 MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQL AQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGY GAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSY TETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGL AFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKE MPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVF PRVLLQTLRHPIFLLVVLSQVCLSSMAAGMAIFLPKFLERQFSITASYANLLIGCLSFPS VIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAH PGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCS CVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVG IQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKT GSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV
- Number of residues
- 709
- Molecular Weight
- 76709.98
- Theoretical pI
- 8.39
- GO Classification
- Functionsbile acid transmembrane transporter activity / organic anion transmembrane transporter activity / sodium-independent organic anion transmembrane transporter activityProcessesanion transmembrane transport / bile acid and bile salt transport / sodium-independent organic anion transport / transmembrane transportComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
- Pfam Domain Function
- OATP (PF03137)
- Transmembrane Regions
- 50-69 89-109 116-140 186-215 235-255 274-298 367-388 409-432 437-460 565-587 597-622 656-673
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010728|Solute carrier organic anion transporter family member 2B1 (SLCO2B1) ATGGGCACAGAAAACACACCTGGAGGCAAAGCCAGCCCAGACCCTCAGGACGTGCGGCCA AGTGTGTTCCATAACATCAAGCTGTTCGTTCTGTGCCACAGCCTGCTGCAGCTGGCGCAG CTCATGATCTCCGGCTACCTAAAGAGCTCCATCTCCACAGTGGAGAAGCGCTTCGGCCTC TCCAGCCAGACGTCGGGGCTGCTGGCCTCCTTCAACGAGGTGGGGAACACAGCCTTGATT GTGTTTGTGAGCTATTTTGGCAGCCGGGTGCACCGACCCCGAATGATTGGCTATGGGGCT ATCCTTGTGGCCCTGGCGGGCCTGCTCATGACTCTCCCGCACTTCATCTCGGAGCCATAC CGCTACGACAACACCAGCCCTGAGGATATGCCACAGGACTTCAAGGCTTCCCTGTGCCTG CCCACAACCTCGGCCCCAGCCTCGGCCCCCTCCAATGGCAACTGCTCAAGCTACACAGAA ACCCAGCATCTGAGTGTGGTGGGGATCATGTTCGTGGCACAGACCCTGCTGGGCGTGGGC GGGGTGCCCATTCAGCCCTTTGGCATCTCCTACATCGATGACTTTGCCCACAACAGCAAC TCGCCCCTCTACCTCGGGATCCTGTTTGCAGTGACCATGATGGGGCCAGGCCTGGCCTTT GGGCTGGGCAGCCTCATGCTGCGCCTTTATGTGGACATTAACCAGATGCCAGAAGGTGGT ATCAGCCTGACCATAAAGGACCCCCGATGGGTGGGTGCCTGGTGGCTGGGTTTCCTCATC GCTGCCGGTGCAGTGGCCCTGGCTGCCATCCCCTACTTCTTCTTCCCCAAGGAAATGCCC AAGGAAAAACGTGAGCTTCAGTTTCGGCGAAAGGTCTTAGCAGTCACAGACTCACCTGCC AGGAAGGGCAAGGACTCTCCCTCTAAGCAGAGCCCTGGGGAGTCCACGAAGAAGCAGGAT GGCCTAGTCCAGATTGCACCAAACCTGACTGTGATCCAGTTCATTAAAGTCTTCCCCAGG GTGCTGCTGCAGACCCTACGCCACCCCATCTTCCTGCTGGTGGTCCTGTCCCAGGTATGC TTGTCATCCATGGCTGCGGGCATGGCCACCTTCCTGCCCAAGTTCCTGGAGCGCCAGTTT TCCATCACAGCCTCCTACGCCAACCTGCTCATCGGCTGCCTCTCCTTCCCTTCGGTCATC GTGGGCATCGTGGTGGGTGGCGTCCTGGTCAAGCGGCTCCACCTGGGCCCTGTGGGATGC GGTGCCCTTTGCCTGCTGGGGATGCTGCTGTGCCTCTTCTTCAGCCTGCCGCTCTTCTTT ATCGGCTGCTCCAGCCACCAGATTGCGGGCATCACACACCAGACCAGTGCCCACCCTGGG CTGGAGCTGTCTCCAAGCTGCATGGAGGCCTGCTCCTGCCCATTGGACGGCTTTAACCCT GTCTGCGACCCCAGCACTCGTGTGGAATACATCACACCCTGCCACGCAGGCTGCTCAAGC TGGGTGGTCCAGGATGCTCTGGACAACAGCCAGGTTTTCTACACCAACTGCAGCTGCGTG GTGGAGGGCAACCCCGTGCTGGCAGGATCCTGCGACTCAACGTGCAGCCATCTGGTGGTG CCCTTCCTGCTCCTGGTCAGCCTGGGCTCGGCCCTGGCCTGTCTCACCCACACACCCTCC TTCATGCTCATCCTAAGAGGAGTGAAGAAAGAAGACAAGACTTTGGCTGTGGGCATCCAG TTCATGTTCCTGAGGATTTTGGCCTGGATGCCCAGCCCCGTGATCCACGGCAGCGCCATC GACACCACCTGTGTGCACTGGGCCCTGAGCTGTGGGCGTCGAGCTGTCTGTCGCTACTAC AATAATGACCTGCTCCGAAACCGGTTCATCGGCCTCCAGTTCTTCTTCAAAACAGGTTCT GTGATCTGCTTCGCCTTAGTTTTGGCTGTCCTGAGGCAGCAGGACAAAGAGGCAAGGACC AAAGAGAGCAGATCCAGCCCTGCCGTAGAGCAGCAATTGCTAGTGTCGGGGCCAGGGAAG AAGCCAGAGGATTCCCGAGTGTGA
- Chromosome Location
- 11
- Locus
- 11q13
- External Identifiers
Resource Link UniProtKB ID O94956 UniProtKB Entry Name SO2B1_HUMAN GenBank Protein ID 5006263 GenBank Gene ID AB026256 GenAtlas ID SLCO2B1 HGNC ID HGNC:10962 - General References
- Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. [Article]
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 1998 Dec 31;5(6):355-64. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Hanggi E, Grundschober AF, Leuthold S, Meier PJ, St-Pierre MV: Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. Mol Pharmacol. 2006 Sep;70(3):806-17. Epub 2006 Jun 5. [Article]
- Knauer MJ, Girdwood AJ, Kim RB, Tirona RG: Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant. Mol Pharmacol. 2013 Jun;83(6):1218-28. doi: 10.1124/mol.112.083618. Epub 2013 Mar 26. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00655 Estrone approved unknown inhibitor Details DB01045 Rifampicin approved unknown inhibitor Details DB02746 Phthalic Acid experimental unknown inhibitor Details DB03902 Oxalic Acid experimental unknown inhibitor Details DB00627 Niacin approved, investigational, nutraceutical unknown inhibitor Details DB04398 Lactic acid approved, vet_approved unknown substrateinhibitor Details DB04272 Citric acid approved, nutraceutical, vet_approved unknown inhibitor Details DB03793 Benzoic acid approved, investigational unknown inhibitor Details DB03166 Acetic acid approved unknown substrateinhibitor Details DB04216 Quercetin experimental, investigational unknown inhibitor Details DB03467 Naringenin experimental unknown inhibitor Details DB00770 Alprostadil approved, investigational unknown substrateinhibitor Details DB00175 Pravastatin approved no substrate Details DB00917 Dinoprostone approved unknown substrate Details DB01053 Benzylpenicillin approved, vet_approved unknown substrate Details DB00286 Conjugated estrogens approved unknown substrate Details DB04348 Taurocholic acid approved, experimental unknown substrate Details DB00950 Fexofenadine approved, investigational unknown substrate Details DB01124 Tolbutamide approved, investigational unknown substrate Details DB01050 Ibuprofen approved unknown substrate Details DB00936 Salicylic acid approved, investigational, vet_approved unknown substrate Details DB01016 Glyburide approved unknown substrate Details DB01088 Iloprost approved, investigational unknown substrate Details DB00471 Montelukast approved unknown substrate Details DB05804 Prasterone sulfate investigational unknown Details DB01076 Atorvastatin approved no substrate Details DB01095 Fluvastatin approved unknown Details DB01098 Rosuvastatin approved unknown Details DB08860 Pitavastatin approved unknown substrate Details DB11613 Velpatasvir approved, investigational no inhibitortransporter Details DB11611 Lifitegrast approved unknown substrate Details DB06290 Simeprevir approved unknown substrate Details DB05521 Telaprevir approved, withdrawn unknown inhibitor Details DB11591 Bilastine approved, investigational unknown inhibitor Details DB13952 Estradiol acetate approved, investigational, vet_approved unknown inhibitor Details DB13953 Estradiol benzoate approved, investigational, vet_approved unknown inhibitor Details DB13954 Estradiol cypionate approved, investigational, vet_approved unknown inhibitor Details DB13955 Estradiol dienanthate approved, investigational, vet_approved unknown inhibitor Details DB13956 Estradiol valerate approved, investigational, vet_approved unknown inhibitor Details DB11660 Latanoprostene bunod approved, investigational unknown substrate Details DB12319 Benzbromarone investigational, withdrawn unknown inhibitor Details DB08862 Cholecystokinin approved, investigational unknown inhibitor Details DB00255 Diethylstilbestrol approved, investigational, withdrawn unknown substrate Details DB00975 Dipyridamole approved unknown inhibitor Details DB00530 Erlotinib approved, investigational unknown inhibitor Details DB01645 Genistein investigational unknown inhibitor Details DB01167 Itraconazole approved, investigational unknown inhibitor Details DB00451 Levothyroxine approved unknown inhibitor Details DB01149 Nefazodone approved, withdrawn unknown inhibitor Details DB00220 Nelfinavir approved no inhibitor Details DB01051 Novobiocin approved, investigational, vet_approved, withdrawn unknown inhibitor Details DB00554 Piroxicam approved, investigational unknown inhibitor Details DB00206 Reserpine approved, investigational, withdrawn unknown inhibitor Details DB09298 Silibinin experimental, investigational unknown inhibitor Details DB00795 Sulfasalazine approved no inhibitor Details DB00759 Tetracycline approved, vet_approved, withdrawn unknown inhibitor Details DB00932 Tipranavir approved, investigational unknown inhibitor Details DB00313 Valproic acid approved, investigational unknown inhibitor Details DB00224 Indinavir approved unknown inhibitor Details DB01232 Saquinavir approved, investigational unknown inhibitor Details DB00503 Ritonavir approved, investigational unknown inhibitor Details DB11586 Asunaprevir approved, investigational, withdrawn unknown substrateinhibitor Details DB05928 Dovitinib investigational unknown inhibitor Details DB09213 Dexibuprofen approved, investigational unknown Details DB11753 Rifamycin approved, investigational no inhibitor Details DB00641 Simvastatin approved unknown Details DB00227 Lovastatin approved, investigational unknown Details DB12978 Pexidartinib approved, investigational unknown inhibitor Details DB01241 Gemfibrozil approved unknown inhibitor Details DB01072 Atazanavir approved, investigational no inhibitor Details DB01708 Prasterone approved, investigational, nutraceutical unknown substrate Details DB11632 Opicapone approved, investigational no substrate Details DB08995 Diosmin approved, investigational unknown Details DB16226 Maralixibat approved, investigational unknown inhibitor Details DB11761 Tenapanor approved, investigational unknown inhibitor Details DB00244 Mesalazine approved unknown substrate Details DB06374 Elacestrant approved, investigational unknown substrate Details