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Identification
NameTiclopidine
Accession NumberDB00208  (APRD01257)
TypeSmall Molecule
GroupsApproved
DescriptionTiclopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who cannot take aspirin or in whom aspirin has not worked to prevent a thrombotic stroke. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Structure
Thumb
Synonyms
Ticlopidina
Ticlopidinum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-ticlopidine - Tab 250mgtablet250 mgoralAltimed Pharma Inc.1996-12-312005-05-27Canada
Dom-ticlopidinetablet250 mgoralDominion Pharmacal2001-05-23Not applicableCanada
Mylan-ticlopidinetablet250 mgoralMylan Pharmaceuticals Ulc1999-03-04Not applicableCanada
Nu-ticlopidine 250 mgtablet250 mgoralNu Pharm Inc1998-06-092012-09-04Canada
PMS-ticlopidinetablet250 mgoralPharmascience Inc2001-02-23Not applicableCanada
Sandoz Ticlopidinetablet250 mgoralSandoz Canada Incorporated2001-05-142011-10-21Canada
Teva-ticlopidinetablet250 mgoralTeva Canada Limited2002-07-30Not applicableCanada
Ticlid 250mg Tabletstablet250 mgoralHoffmann La Roche Limited1995-12-312006-07-25Canada
Ticlid Tab 250mgtablet250 mgoralSyntex Inc.1992-12-311996-09-30Canada
Ticlopidinetablet250 mgoralSanis Health Inc2010-02-162014-08-01Canada
Ticlopidine-250tablet250 mgoralPro Doc Limitee1999-11-182010-07-13Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-ticlopidine Tabletstablet250 mgoralApotex Inc1998-03-30Not applicableCanada
Ticlopidine Hydrochloridetablet, film coated250 mg/1oralTeva Pharmaceuticals USA Inc1999-09-072016-02-25Us
Ticlopidine Hydrochloridetablet, film coated250 mg/1oralCarilion Materials Management1999-09-07Not applicableUs
Ticlopidine Hydrochloridetablet, film coated250 mg/1oralEon Labs, Inc.1999-08-20Not applicableUs
Ticlopidine Hydrochloridetablet, film coated250 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2002-09-26Not applicableUs
Ticlopidine Hydrochloridetablet, film coated250 mg/1oralApotex Corp.1999-07-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
TiclidROCHE PALO
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Ticlopidine Hydrochloride
53885-35-1
Thumb
  • InChI Key: MTKNGOHFNXIVOS-UHFFFAOYSA-N
  • Monoisotopic Mass: 299.030225589
  • Average Mass: 300.247
DBSALT000179
Categories
UNIIOM90ZUW7M1
CAS number55142-85-3
WeightAverage: 263.786
Monoisotopic: 263.05354785
Chemical FormulaC14H14ClNS
InChI KeyInChIKey=PHWBOXQYWZNQIN-UHFFFAOYSA-N
InChI
InChI=1S/C14H14ClNS/c15-13-4-2-1-3-11(13)9-16-7-5-14-12(10-16)6-8-17-14/h1-4,6,8H,5,7,9-10H2
IUPAC Name
5-[(2-chlorophenyl)methyl]-4H,5H,6H,7H-thieno[3,2-c]pyridine
SMILES
ClC1=CC=CC=C1CN1CCC2=C(C1)C=CS2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as thienopyridines. These are heterocyclic compounds containing a thiophene ring fused to a pyridine ring. Thiophene is 5-membered ring consisting of four carbon atoms and one sulfur atom. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassThienopyridines
Sub ClassNot Available
Direct ParentThienopyridines
Alternative Parents
Substituents
  • Thienopyridine
  • Phenylmethylamine
  • Benzylamine
  • Aralkylamine
  • Halobenzene
  • Chlorobenzene
  • Benzenoid
  • Pyridine
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Thiophene
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed in patients, who have had a stroke or stroke precursors and who cannot take aspirin or aspirin has not worked, to try to prevent another thrombotic stroke.
PharmacodynamicsTiclopidine is a prodrug that is metabolised to an as yet undetermined metabolite that acts as a platelet aggregation inhibitor. Inhibition of platelet aggregation causes a prolongation of bleeding time. In its prodrug form, ticlopidine has no significant in vitro activity at the concentrations attained in vivo.
Mechanism of actionThe active metabolite of ticlopidine prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. It is proposed that the inhibition involves a defect in the mobilization from the storage sites of the platelet granules to the outer membrane. No direct interference occurs with the GPIIb/IIIa receptor. As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of ticlopidine.
Related Articles
AbsorptionAbsorption is greater than 80%. Food increases absorption by approximately 20%.
Volume of distribution

The volume of distribution was not quantified.

Protein bindingBinds reversibly (98%) to plasma proteins, mainly to serum albumin and lipoproteins. The binding to albumin and lipoproteins is nonsaturable over a wide concentration range. Ticlopidine also binds to alpha-1 acid glycoprotein (about 15% or less).
Metabolism

Ticlopidine is metabolized extensively by the liver with only trace amounts of intact drug detected. At least 20 metabolites have been identified.

SubstrateEnzymesProduct
Ticlopidine
2-ChloroticlopidineDetails
Ticlopidine
2-OxoticlopidineDetails
Ticlopidine
ThienodihydropyridiniumDetails
Ticlopidine
Ticlopidine S-oxideDetails
Ticlopidine
Dehydrogenated ticlopidineDetails
Ticlopidine
Ticlopidine N-oxideDetails
Ticlopidine
di-HydroxyticlopidineDetails
Ticlopidine
Not Available
7-HydroxyticlopidineDetails
2-Oxoticlopidine
Not Available
Active metabolite of TiclopidineDetails
Ticlopidine S-oxide
Not Available
Ticlopidine S-oxide dimerDetails
Thienodihydropyridinium
ThienopyridiniumDetails
Thienodihydropyridinium
Ticlopidine lactam analog (M8)Details
Route of eliminationTiclopidine is eliminated mostly in the urine (60%) and somewhat in the feces (23%).
Half lifeHalf-life following a single 250-mg dose is approximately 7.9 hours in subjects 20 to 43 years of age and 12.6 hours in subjects 65 to 76 years of age. With repeated dosing (250 mg twice a day), half-life is about 4 days in subjects 20 to 43 years of age and about 5 days in subjects 65 to 76 years of age.
Clearance

Ticlopidine clearance was not quantified, but clearance decreases with age.

ToxicitySingle oral doses of ticlopidine at 1600 mg/kg and 500 mg/kg were lethal to rats and mice, respectively. Symptoms of acute toxicity were GI hemorrhage, convulsions, hypothermia, dyspnea, loss of equilibrium and abnormal gait. The FDA label includes a black-box warning of neutropenia, aplastic anemia, thrombotic thrombocytopenia purpura, and agranulocytosis, so it is necessary to monitor patients' WBC and platelets when they are taking ticlopidine.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Ticlopidine Metabolism PathwayDrug metabolismSMP00611
Ticlopidine Action PathwayDrug actionSMP00261
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9902
Blood Brain Barrier+0.9906
Caco-2 permeable+0.6062
P-glycoprotein substrateSubstrate0.6111
P-glycoprotein inhibitor IInhibitor0.8
P-glycoprotein inhibitor IIInhibitor0.8513
Renal organic cation transporterInhibitor0.8152
CYP450 2C9 substrateNon-substrate0.8234
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateNon-substrate0.5155
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorInhibitor0.9209
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorNon-inhibitor0.8808
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9666
Ames testNon AMES toxic0.6773
CarcinogenicityNon-carcinogens0.9414
BiodegradationNot ready biodegradable0.9959
Rat acute toxicity2.2022 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.6392
hERG inhibition (predictor II)Inhibitor0.6333
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Roche palo alto llc
  • Actavis elizabeth llc
  • Apotex inc
  • Caraco pharmaceutical laboratories ltd
  • Genpharm inc
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral250 mg
Tablet, film coatedoral250 mg/1
Prices
Unit descriptionCostUnit
Ticlid 30 250 mg tablet Bottle87.36USD bottle
Ticlid 250 mg tablet2.61USD tablet
Ticlopidine HCl 250 mg tablet2.1USD tablet
Ticlopidine 250 mg tablet1.86USD tablet
Apo-Ticlopidine 250 mg Tablet0.72USD tablet
Mylan-Ticlopidine 250 mg Tablet0.72USD tablet
Novo-Ticlopidine 250 mg Tablet0.72USD tablet
Nu-Ticlopidine 250 mg Tablet0.72USD tablet
Sandoz Ticlopidine 250 mg Tablet0.72USD tablet
Ticlopidine 250 mg Tablet0.72USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting pointapprox. 1 189°CFrom Remington: The Science and Practice of Pharmacy
water solubilityFreely solubleFrom Remington: The Science and Practice of Pharmacy
logP2.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0219 mg/mLALOGPS
logP4.25ALOGPS
logP4.2ChemAxon
logS-4.1ALOGPS
pKa (Strongest Basic)7.31ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area3.24 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity74.33 m3·mol-1ChemAxon
Polarizability27.99 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesB01AC05
AHFS Codes
  • 20:12.18
PDB EntriesNot Available
FDA labelDownload (916 KB)
MSDSDownload (106 KB)
Interactions
Drug Interactions
Drug
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Ticlopidine.
AbciximabTiclopidine may increase the anticoagulant activities of Abciximab.
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Ticlopidine.
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Ticlopidine.
AcenocoumarolTiclopidine may increase the anticoagulant activities of Acenocoumarol.
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Ticlopidine.
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Ticlopidine.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Ticlopidine.
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Ticlopidine.
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Ticlopidine.
AjmalineThe metabolism of Ajmaline can be decreased when combined with Ticlopidine.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Ticlopidine.
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Ticlopidine.
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Ticlopidine.
AlfuzosinThe metabolism of Alfuzosin can be decreased when combined with Ticlopidine.
AliskirenThe metabolism of Aliskiren can be decreased when combined with Ticlopidine.
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Ticlopidine.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Ticlopidine.
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Ticlopidine.
AlosetronThe metabolism of Alosetron can be decreased when combined with Ticlopidine.
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Ticlopidine.
AlprenololThe metabolism of Alprenolol can be decreased when combined with Ticlopidine.
AlprostadilAlprostadil may increase the anticoagulant activities of Ticlopidine.
AlprostadilTiclopidine may increase the antiplatelet activities of Alprostadil.
AlteplaseTiclopidine may increase the anticoagulant activities of Alteplase.
ALX-0081Ticlopidine may increase the anticoagulant activities of ALX-0081.
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Ticlopidine.
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Ticlopidine.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Ticlopidine.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Ticlopidine.
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Ticlopidine.
AmiodaroneThe metabolism of Amiodarone can be decreased when combined with Ticlopidine.
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Ticlopidine.
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Ticlopidine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Ticlopidine.
AmoxapineThe metabolism of Amoxapine can be decreased when combined with Ticlopidine.
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Ticlopidine.
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Ticlopidine.
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Ticlopidine.
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Ticlopidine.
AnagrelideTiclopidine may increase the anticoagulant activities of Anagrelide.
AncrodTiclopidine may increase the anticoagulant activities of Ancrod.
AnilineThe metabolism of Aniline can be decreased when combined with Ticlopidine.
AnistreplaseTiclopidine may increase the anticoagulant activities of Anistreplase.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Ticlopidine.
Antithrombin III humanTiclopidine may increase the anticoagulant activities of Antithrombin III human.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Ticlopidine.
ApremilastThe metabolism of Apremilast can be decreased when combined with Ticlopidine.
AprepitantThe serum concentration of Ticlopidine can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Ticlopidine.
AprindineThe metabolism of Aprindine can be decreased when combined with Ticlopidine.
AprotininThe therapeutic efficacy of Ticlopidine can be decreased when used in combination with Aprotinin.
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Ticlopidine.
ArdeparinTiclopidine may increase the anticoagulant activities of Ardeparin.
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Ticlopidine.
ArgatrobanTiclopidine may increase the anticoagulant activities of Argatroban.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Ticlopidine.
ArmodafinilThe metabolism of Ticlopidine can be decreased when combined with Armodafinil.
ArtemetherThe metabolism of Artemether can be decreased when combined with Ticlopidine.
ASA404The metabolism of ASA404 can be decreased when combined with Ticlopidine.
AsenapineThe metabolism of Asenapine can be decreased when combined with Ticlopidine.
AstaxanthinTiclopidine may increase the anticoagulant activities of Astaxanthin.
AstemizoleThe metabolism of Astemizole can be decreased when combined with Ticlopidine.
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Ticlopidine.
AtomoxetineThe metabolism of Ticlopidine can be decreased when combined with Atomoxetine.
AtorvastatinThe metabolism of Atorvastatin can be decreased when combined with Ticlopidine.
AV650The metabolism of AV650 can be decreased when combined with Ticlopidine.
AvanafilThe metabolism of Avanafil can be decreased when combined with Ticlopidine.
AxitinibThe metabolism of Axitinib can be decreased when combined with Ticlopidine.
AzelastineAzelastine may increase the anticoagulant activities of Ticlopidine.
AzelastineThe metabolism of Azelastine can be decreased when combined with Ticlopidine.
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Ticlopidine.
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Ticlopidine.
BatroxobinTiclopidine may increase the anticoagulant activities of Batroxobin.
BecaplerminTiclopidine may increase the anticoagulant activities of Becaplermin.
BedaquilineThe metabolism of Bedaquiline can be decreased when combined with Ticlopidine.
BemiparinTiclopidine may increase the anticoagulant activities of Bemiparin.
BendamustineThe metabolism of Bendamustine can be decreased when combined with Ticlopidine.
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Ticlopidine.
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Ticlopidine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Ticlopidine.
BepridilThe metabolism of Bepridil can be decreased when combined with Ticlopidine.
BeraprostTiclopidine may increase the anticoagulant activities of Beraprost.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Ticlopidine.
BexaroteneThe serum concentration of Ticlopidine can be decreased when it is combined with Bexarotene.
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Ticlopidine.
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Ticlopidine.
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Ticlopidine.
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Ticlopidine.
BivalirudinTiclopidine may increase the anticoagulant activities of Bivalirudin.
BoceprevirThe metabolism of Boceprevir can be decreased when combined with Ticlopidine.
BortezomibThe metabolism of Ticlopidine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Ticlopidine can be decreased when it is combined with Bosentan.
BosentanThe serum concentration of Bosentan can be increased when it is combined with Ticlopidine.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Ticlopidine.
Brentuximab vedotinThe metabolism of Brentuximab vedotin can be decreased when combined with Ticlopidine.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Ticlopidine.
BrinzolamideThe metabolism of Brinzolamide can be decreased when combined with Ticlopidine.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Ticlopidine.
BromocriptineThe metabolism of Bromocriptine can be decreased when combined with Ticlopidine.
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Ticlopidine.
BudesonideThe metabolism of Budesonide can be decreased when combined with Ticlopidine.
BufuralolThe metabolism of Bufuralol can be decreased when combined with Ticlopidine.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Ticlopidine.
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Ticlopidine.
BupropionThe serum concentration of Bupropion can be increased when it is combined with Ticlopidine.
BupropionThe metabolism of Ticlopidine can be decreased when combined with Bupropion.
BuspironeThe metabolism of Buspirone can be decreased when combined with Ticlopidine.
BusulfanThe metabolism of Busulfan can be decreased when combined with Ticlopidine.
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Ticlopidine.
CabergolineThe metabolism of Cabergoline can be decreased when combined with Ticlopidine.
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Ticlopidine.
CaffeineThe metabolism of Caffeine can be decreased when combined with Ticlopidine.
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Ticlopidine.
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Ticlopidine.
CandesartanThe metabolism of Candesartan can be decreased when combined with Ticlopidine.
CangrelorTiclopidine may increase the anticoagulant activities of Cangrelor.
CapsaicinThe metabolism of Capsaicin can be decreased when combined with Ticlopidine.
CaptoprilThe metabolism of Captopril can be decreased when combined with Ticlopidine.
CarbamazepineThe metabolism of Ticlopidine can be increased when combined with Carbamazepine.
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Ticlopidine.
CariprazineThe metabolism of Cariprazine can be decreased when combined with Ticlopidine.
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Ticlopidine.
CarmustineThe metabolism of Carmustine can be decreased when combined with Ticlopidine.
CarteololThe metabolism of Carteolol can be decreased when combined with Ticlopidine.
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Ticlopidine.
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Ticlopidine.
CeliprololThe metabolism of Celiprolol can be decreased when combined with Ticlopidine.
CephalexinThe metabolism of Cephalexin can be decreased when combined with Ticlopidine.
CeritinibThe serum concentration of Ticlopidine can be increased when it is combined with Ceritinib.
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Ticlopidine.
CertoparinTiclopidine may increase the anticoagulant activities of Certoparin.
CevimelineThe metabolism of Cevimeline can be decreased when combined with Ticlopidine.
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Ticlopidine.
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Ticlopidine.
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Ticlopidine.
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Ticlopidine.
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Ticlopidine.
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Ticlopidine.
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Ticlopidine.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Ticlopidine.
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Ticlopidine.
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Ticlopidine.
CilostazolTiclopidine may increase the anticoagulant activities of Cilostazol.
CimetidineThe metabolism of Ticlopidine can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Ticlopidine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Ticlopidine.
CisaprideThe metabolism of Cisapride can be decreased when combined with Ticlopidine.
CitalopramThe metabolism of Citalopram can be decreased when combined with Ticlopidine.
Citric AcidTiclopidine may increase the anticoagulant activities of Citric Acid.
ClarithromycinThe metabolism of Clarithromycin can be decreased when combined with Ticlopidine.
ClemastineThe metabolism of Ticlopidine can be decreased when combined with Clemastine.
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Ticlopidine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Ticlopidine.
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Ticlopidine.
ClobazamThe metabolism of Clobazam can be decreased when combined with Ticlopidine.
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Ticlopidine.
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Ticlopidine.
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Ticlopidine.
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Ticlopidine.
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Ticlopidine.
ClonidineThe metabolism of Clonidine can be decreased when combined with Ticlopidine.
ClopidogrelTiclopidine may increase the anticoagulant activities of Clopidogrel.
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Ticlopidine.
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Ticlopidine.
ClotrimazoleThe metabolism of Ticlopidine can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Clozapine can be decreased when combined with Ticlopidine.
CobicistatThe serum concentration of Ticlopidine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Ticlopidine.
CocaineThe metabolism of Cocaine can be decreased when combined with Ticlopidine.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Ticlopidine.
ColchicineThe metabolism of Colchicine can be decreased when combined with Ticlopidine.
CollagenaseThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Collagenase.
ConivaptanThe serum concentration of Ticlopidine can be increased when it is combined with Conivaptan.
ConivaptanThe metabolism of Conivaptan can be decreased when combined with Ticlopidine.
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Ticlopidine.
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Ticlopidine.
CrizotinibThe metabolism of Crizotinib can be decreased when combined with Ticlopidine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Ticlopidine.
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Ticlopidine.
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Ticlopidine.
CytarabineThe metabolism of Cytarabine can be decreased when combined with Ticlopidine.
Dabigatran etexilateTiclopidine may increase the anticoagulant activities of Dabigatran etexilate.
DabrafenibThe serum concentration of Ticlopidine can be decreased when it is combined with Dabrafenib.
DabrafenibThe metabolism of Dabrafenib can be decreased when combined with Ticlopidine.
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Ticlopidine.
DaclatasvirThe metabolism of Daclatasvir can be decreased when combined with Ticlopidine.
DalfampridineThe metabolism of Dalfampridine can be decreased when combined with Ticlopidine.
DalteparinTiclopidine may increase the anticoagulant activities of Dalteparin.
DanaparoidTiclopidine may increase the anticoagulant activities of Danaparoid.
DantroleneThe metabolism of Dantrolene can be decreased when combined with Ticlopidine.
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Ticlopidine.
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Ticlopidine.
DapsoneThe metabolism of Dapsone can be decreased when combined with Ticlopidine.
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Ticlopidine.
DarunavirThe serum concentration of Ticlopidine can be increased when it is combined with Darunavir.
DarunavirThe metabolism of Darunavir can be decreased when combined with Ticlopidine.
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Ticlopidine.
DasatinibDasatinib may increase the anticoagulant activities of Ticlopidine.
DasatinibThe metabolism of Dasatinib can be decreased when combined with Ticlopidine.
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Ticlopidine.
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Ticlopidine.
DeferasiroxThe serum concentration of Ticlopidine can be decreased when it is combined with Deferasirox.
DefibrotideTiclopidine may increase the anticoagulant activities of Defibrotide.
DehydroepiandrosteroneThe metabolism of Dehydroepiandrosterone can be decreased when combined with Ticlopidine.
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Ticlopidine.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Deoxycholic Acid.
DesipramineThe metabolism of Desipramine can be decreased when combined with Ticlopidine.
DesirudinTiclopidine may increase the anticoagulant activities of Desirudin.
DesmoteplaseTiclopidine may increase the anticoagulant activities of Desmoteplase.
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Ticlopidine.
DexamethasoneThe serum concentration of Ticlopidine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Ticlopidine.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Ticlopidine.
DexmedetomidineThe metabolism of Dexmedetomidine can be decreased when combined with Ticlopidine.
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Ticlopidine.
DextranTiclopidine may increase the anticoagulant activities of Dextran.
Dextran 40Ticlopidine may increase the anticoagulant activities of Dextran 40.
Dextran 70Ticlopidine may increase the anticoagulant activities of Dextran 70.
Dextran 75Ticlopidine may increase the anticoagulant activities of Dextran 75.
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Ticlopidine.
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Ticlopidine.
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Ticlopidine.
DiazepamThe metabolism of Diazepam can be decreased when combined with Ticlopidine.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Ticlopidine.
DicoumarolTiclopidine may increase the anticoagulant activities of Dicoumarol.
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Ticlopidine.
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Ticlopidine.
DigoxinThe metabolism of Digoxin can be decreased when combined with Ticlopidine.
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Ticlopidine.
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Ticlopidine.
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Ticlopidine.
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Ticlopidine.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Ticlopidine.
DipyridamoleTiclopidine may increase the anticoagulant activities of Dipyridamole.
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Ticlopidine.
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Ticlopidine.
DitazoleTiclopidine may increase the anticoagulant activities of Ditazole.
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Ticlopidine.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Ticlopidine.
DolasetronThe metabolism of Dolasetron can be decreased when combined with Ticlopidine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Ticlopidine.
DonepezilThe metabolism of Donepezil can be decreased when combined with Ticlopidine.
DopamineThe metabolism of Dopamine can be decreased when combined with Ticlopidine.
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Ticlopidine.
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Ticlopidine.
DoxepinThe metabolism of Doxepin can be decreased when combined with Ticlopidine.
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Ticlopidine.
DoxycyclineThe metabolism of Ticlopidine can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Ticlopidine.
DronedaroneThe metabolism of Dronedarone can be decreased when combined with Ticlopidine.
Drotrecogin alfaTiclopidine may increase the anticoagulant activities of Drotrecogin alfa.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Ticlopidine.
DutasterideThe metabolism of Dutasteride can be decreased when combined with Ticlopidine.
DyphyllineThe metabolism of Dyphylline can be decreased when combined with Ticlopidine.
Edetic AcidTiclopidine may increase the anticoagulant activities of Edetic Acid.
EdoxabanTiclopidine may increase the anticoagulant activities of Edoxaban.
EfavirenzThe serum concentration of Ticlopidine can be decreased when it is combined with Efavirenz.
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Ticlopidine.
EletriptanThe metabolism of Eletriptan can be decreased when combined with Ticlopidine.
EliglustatThe metabolism of Eliglustat can be decreased when combined with Ticlopidine.
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Ticlopidine.
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Ticlopidine.
EnalaprilThe metabolism of Enalapril can be decreased when combined with Ticlopidine.
EncainideThe metabolism of Encainide can be decreased when combined with Ticlopidine.
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Ticlopidine.
EnfluraneThe metabolism of Enflurane can be decreased when combined with Ticlopidine.
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Ticlopidine.
EnoxaparinTiclopidine may increase the anticoagulant activities of Enoxaparin.
EnzalutamideThe serum concentration of Ticlopidine can be decreased when it is combined with Enzalutamide.
EnzalutamideThe metabolism of Enzalutamide can be decreased when combined with Ticlopidine.
EpinastineEpinastine may increase the anticoagulant activities of Ticlopidine.
EpinastineThe metabolism of Epinastine can be decreased when combined with Ticlopidine.
EplerenoneThe metabolism of Eplerenone can be decreased when combined with Ticlopidine.
EpoprostenolTiclopidine may increase the anticoagulant activities of Epoprostenol.
EptifibatideEptifibatide may increase the anticoagulant activities of Ticlopidine.
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Ticlopidine.
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be decreased when combined with Ticlopidine.
ErgonovineThe metabolism of Ergonovine can be decreased when combined with Ticlopidine.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Ticlopidine.
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Ticlopidine.
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Ticlopidine.
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Ticlopidine.
Eslicarbazepine acetateThe serum concentration of Ticlopidine can be decreased when it is combined with Eslicarbazepine acetate.
EsmirtazapineThe metabolism of Esmirtazapine can be decreased when combined with Ticlopidine.
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Ticlopidine.
EstazolamThe metabolism of Estazolam can be decreased when combined with Ticlopidine.
EstradiolThe metabolism of Estradiol can be decreased when combined with Ticlopidine.
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Ticlopidine.
EstramustineThe metabolism of Estramustine can be decreased when combined with Ticlopidine.
EstroneThe metabolism of Estrone can be decreased when combined with Ticlopidine.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Ticlopidine.
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Ticlopidine.
EthanolThe metabolism of Ethanol can be decreased when combined with Ticlopidine.
Ethanolamine OleateThe metabolism of Ethanolamine Oleate can be decreased when combined with Ticlopidine.
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Ticlopidine.
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Ticlopidine.
Ethyl biscoumacetateTiclopidine may increase the anticoagulant activities of Ethyl biscoumacetate.
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Ticlopidine.
EtodolacThe metabolism of Etodolac can be decreased when combined with Ticlopidine.
EtonogestrelThe metabolism of Etonogestrel can be decreased when combined with Ticlopidine.
EtoposideThe metabolism of Etoposide can be decreased when combined with Ticlopidine.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Ticlopidine.
EtravirineThe serum concentration of Ticlopidine can be decreased when it is combined with Etravirine.
EtravirineThe metabolism of Etravirine can be decreased when combined with Ticlopidine.
EverolimusThe metabolism of Everolimus can be decreased when combined with Ticlopidine.
ExemestaneThe metabolism of Exemestane can be decreased when combined with Ticlopidine.
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Ticlopidine.
FamotidineThe metabolism of Famotidine can be decreased when combined with Ticlopidine.
FelbamateThe metabolism of Felbamate can be decreased when combined with Ticlopidine.
FelodipineThe metabolism of Felodipine can be decreased when combined with Ticlopidine.
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Ticlopidine.
FentanylThe metabolism of Fentanyl can be decreased when combined with Ticlopidine.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Ticlopidine.
FibrinolysinTiclopidine may increase the anticoagulant activities of Fibrinolysin.
FinasterideThe metabolism of Finasteride can be decreased when combined with Ticlopidine.
FingolimodThe metabolism of Fingolimod can be decreased when combined with Ticlopidine.
FlecainideThe metabolism of Flecainide can be decreased when combined with Ticlopidine.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Ticlopidine.
FluconazoleThe metabolism of Ticlopidine can be decreased when combined with Fluconazole.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Ticlopidine.
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Ticlopidine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Ticlopidine.
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Ticlopidine.
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Ticlopidine.
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Ticlopidine.
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Ticlopidine.
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Ticlopidine.
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Ticlopidine.
FlutamideThe metabolism of Flutamide can be decreased when combined with Ticlopidine.
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Ticlopidine.
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Ticlopidine.
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Ticlopidine.
FluvoxamineThe metabolism of Ticlopidine can be decreased when combined with Fluvoxamine.
Folic AcidThe metabolism of Folic Acid can be decreased when combined with Ticlopidine.
Fondaparinux sodiumTiclopidine may increase the anticoagulant activities of Fondaparinux sodium.
FormoterolThe metabolism of Formoterol can be decreased when combined with Ticlopidine.
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Ticlopidine.
FosaprepitantThe serum concentration of Ticlopidine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Ticlopidine.
FosphenytoinThe metabolism of Ticlopidine can be increased when combined with Fosphenytoin.
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Ticlopidine.
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Ticlopidine.
Fusidic AcidThe serum concentration of Ticlopidine can be increased when it is combined with Fusidic Acid.
GalantamineThe metabolism of Galantamine can be decreased when combined with Ticlopidine.
GavestinelThe metabolism of Gavestinel can be decreased when combined with Ticlopidine.
GefitinibThe metabolism of Gefitinib can be decreased when combined with Ticlopidine.
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Ticlopidine.
GenisteinThe metabolism of Genistein can be decreased when combined with Ticlopidine.
GliclazideThe metabolism of Gliclazide can be decreased when combined with Ticlopidine.
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Ticlopidine.
GlipizideThe metabolism of Glipizide can be decreased when combined with Ticlopidine.
GlucosamineGlucosamine may increase the antiplatelet activities of Ticlopidine.
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Ticlopidine.
GlyburideThe metabolism of Glyburide can be decreased when combined with Ticlopidine.
GranisetronThe metabolism of Granisetron can be decreased when combined with Ticlopidine.
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Ticlopidine.
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Ticlopidine.
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Ticlopidine.
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Ticlopidine.
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Ticlopidine.
HalothaneThe metabolism of Halothane can be decreased when combined with Ticlopidine.
HeparinTiclopidine may increase the anticoagulant activities of Heparin.
HesperetinThe metabolism of Hesperetin can be decreased when combined with Ticlopidine.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Ticlopidine.
HirulogTiclopidine may increase the anticoagulant activities of Hirulog.
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Ticlopidine.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Ticlopidine.
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Ticlopidine.
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Ticlopidine.
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Ticlopidine.
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Ibritumomab tiuxetan.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Ticlopidine.
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Ticlopidine.
IbudilastIbudilast may increase the anticoagulant activities of Ticlopidine.
IbudilastTiclopidine may increase the antiplatelet activities of Ibudilast.
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Ticlopidine.
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Ticlopidine.
Icosapent ethylTiclopidine may increase the antiplatelet activities of Icosapent ethyl.
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Ticlopidine.
IdelalisibThe serum concentration of Ticlopidine can be increased when it is combined with Idelalisib.
IfenprodilIfenprodil may increase the anticoagulant activities of Ticlopidine.
IfenprodilTiclopidine may increase the antiplatelet activities of Ifenprodil.
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Ticlopidine resulting in a loss in efficacy.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Ticlopidine.
IloprostTiclopidine may increase the anticoagulant activities of Iloprost.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Ticlopidine.
ImatinibThe metabolism of Ticlopidine can be decreased when combined with Imatinib.
ImipramineThe metabolism of Imipramine can be decreased when combined with Ticlopidine.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Ticlopidine.
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Ticlopidine.
IndapamideThe metabolism of Indapamide can be decreased when combined with Ticlopidine.
IndinavirThe metabolism of Indinavir can be decreased when combined with Ticlopidine.
indisulamThe metabolism of indisulam can be decreased when combined with Ticlopidine.
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Ticlopidine.
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Ticlopidine.
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Ticlopidine.
IrinotecanThe metabolism of Irinotecan can be decreased when combined with Ticlopidine.
IsavuconazoniumThe metabolism of Isavuconazonium can be decreased when combined with Ticlopidine.
IsofluraneThe metabolism of Isoflurane can be decreased when combined with Ticlopidine.
IsoniazidThe metabolism of Ticlopidine can be decreased when combined with Isoniazid.
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Ticlopidine.
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Ticlopidine.
IsradipineThe metabolism of Isradipine can be decreased when combined with Ticlopidine.
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Ticlopidine.
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Ticlopidine.
IvacaftorThe serum concentration of Ticlopidine can be increased when it is combined with Ivacaftor.
IvacaftorThe metabolism of Ivacaftor can be decreased when combined with Ticlopidine.
IvermectinThe metabolism of Ivermectin can be decreased when combined with Ticlopidine.
IxabepiloneThe metabolism of Ixabepilone can be decreased when combined with Ticlopidine.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Ticlopidine.
KetamineThe metabolism of Ketamine can be decreased when combined with Ticlopidine.
KetazolamThe metabolism of Ketazolam can be decreased when combined with Ticlopidine.
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Ticlopidine.
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Ticlopidine.
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Ticlopidine.
LabetalolThe metabolism of Labetalol can be decreased when combined with Ticlopidine.
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Ticlopidine.
LapatinibThe metabolism of Lapatinib can be decreased when combined with Ticlopidine.
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Ticlopidine.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Ticlopidine.
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Ticlopidine.
LepirudinTiclopidine may increase the anticoagulant activities of Lepirudin.
LercanidipineThe metabolism of Lercanidipine can be decreased when combined with Ticlopidine.
LesinuradThe metabolism of Lesinurad can be decreased when combined with Ticlopidine.
LetrozoleThe metabolism of Letrozole can be decreased when combined with Ticlopidine.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Ticlopidine.
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Ticlopidine.
LevodopaThe metabolism of Levodopa can be decreased when combined with Ticlopidine.
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Ticlopidine.
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Ticlopidine.
LevonorgestrelThe metabolism of Levonorgestrel can be decreased when combined with Ticlopidine.
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Ticlopidine.
LicofeloneThe metabolism of Licofelone can be decreased when combined with Ticlopidine.
LidocaineThe metabolism of Lidocaine can be decreased when combined with Ticlopidine.
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Ticlopidine.
LisurideThe metabolism of Lisuride can be decreased when combined with Ticlopidine.
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Ticlopidine.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Ticlopidine.
LomustineThe metabolism of Lomustine can be decreased when combined with Ticlopidine.
LoperamideThe metabolism of Loperamide can be decreased when combined with Ticlopidine.
LopinavirThe metabolism of Lopinavir can be decreased when combined with Ticlopidine.
LoratadineThe metabolism of Loratadine can be decreased when combined with Ticlopidine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Ticlopidine.
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Ticlopidine.
LosartanThe metabolism of Losartan can be decreased when combined with Ticlopidine.
LovastatinThe metabolism of Lovastatin can be decreased when combined with Ticlopidine.
LuliconazoleThe serum concentration of Ticlopidine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Ticlopidine can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Lumefantrine can be decreased when combined with Ticlopidine.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Ticlopidine.
LurasidoneThe metabolism of Lurasidone can be decreased when combined with Ticlopidine.
MacitentanThe metabolism of Macitentan can be decreased when combined with Ticlopidine.
MalathionThe metabolism of Malathion can be decreased when combined with Ticlopidine.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Ticlopidine.
MaravirocThe metabolism of Maraviroc can be decreased when combined with Ticlopidine.
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Ticlopidine.
Medroxyprogesterone acetateThe metabolism of Medroxyprogesterone acetate can be decreased when combined with Ticlopidine.
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Ticlopidine.
MefloquineThe metabolism of Mefloquine can be decreased when combined with Ticlopidine.
MelatoninThe metabolism of Melatonin can be decreased when combined with Ticlopidine.
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Ticlopidine.
MenadioneThe metabolism of Menadione can be decreased when combined with Ticlopidine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Ticlopidine.
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Ticlopidine.
MequitazineThe metabolism of Mequitazine can be decreased when combined with Ticlopidine.
MesalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Ticlopidine.
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Ticlopidine.
MestranolThe metabolism of Mestranol can be decreased when combined with Ticlopidine.
MethadoneThe metabolism of Methadone can be decreased when combined with Ticlopidine.
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Ticlopidine.
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Ticlopidine.
MethotrimeprazineThe metabolism of Methotrimeprazine can be decreased when combined with Ticlopidine.
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Ticlopidine.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Ticlopidine.
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Ticlopidine.
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Ticlopidine.
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Ticlopidine.
MethylprednisoloneThe metabolism of Methylprednisolone can be decreased when combined with Ticlopidine.
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Ticlopidine.
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Ticlopidine.
MetoclopramideThe metabolism of Metoclopramide can be decreased when combined with Ticlopidine.
MetoprololThe metabolism of Ticlopidine can be decreased when combined with Metoprolol.
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Ticlopidine.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Ticlopidine.
MianserinThe metabolism of Mianserin can be decreased when combined with Ticlopidine.
MibefradilThe metabolism of Mibefradil can be decreased when combined with Ticlopidine.
MiconazoleThe metabolism of Miconazole can be decreased when combined with Ticlopidine.
MidazolamThe metabolism of Midazolam can be decreased when combined with Ticlopidine.
MifepristoneThe metabolism of Mifepristone can be decreased when combined with Ticlopidine.
MilrinoneMilrinone may increase the anticoagulant activities of Ticlopidine.
MilrinoneTiclopidine may increase the antiplatelet activities of Milrinone.
MinaprineThe metabolism of Minaprine can be decreased when combined with Ticlopidine.
MirabegronThe metabolism of Mirabegron can be decreased when combined with Ticlopidine.
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Ticlopidine.
MitotaneThe serum concentration of Ticlopidine can be decreased when it is combined with Mitotane.
MitoxantroneThe metabolism of Mitoxantrone can be decreased when combined with Ticlopidine.
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Ticlopidine.
ModafinilThe serum concentration of Ticlopidine can be decreased when it is combined with Modafinil.
ModafinilThe metabolism of Modafinil can be decreased when combined with Ticlopidine.
MontelukastThe metabolism of Montelukast can be decreased when combined with Ticlopidine.
MorphineThe metabolism of Morphine can be decreased when combined with Ticlopidine.
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Ticlopidine.
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Ticlopidine.
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Ticlopidine.
NadroparinTiclopidine may increase the anticoagulant activities of Nadroparin.
NafcillinThe serum concentration of Ticlopidine can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Ticlopidine.
NaloxoneThe metabolism of Naloxone can be decreased when combined with Ticlopidine.
NaproxenThe metabolism of Naproxen can be decreased when combined with Ticlopidine.
NateglinideThe metabolism of Nateglinide can be decreased when combined with Ticlopidine.
NCX 4016Ticlopidine may increase the anticoagulant activities of NCX 4016.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Ticlopidine.
NefazodoneThe metabolism of Nefazodone can be decreased when combined with Ticlopidine.
NelfinavirThe metabolism of Nelfinavir can be decreased when combined with Ticlopidine.
NetupitantThe serum concentration of Ticlopidine can be increased when it is combined with Netupitant.
NetupitantThe metabolism of Netupitant can be decreased when combined with Ticlopidine.
NevirapineThe metabolism of Nevirapine can be decreased when combined with Ticlopidine.
NicardipineThe metabolism of Nicardipine can be decreased when combined with Ticlopidine.
NicergolineThe metabolism of Nicergoline can be decreased when combined with Ticlopidine.
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Ticlopidine.
NicotineThe metabolism of Nicotine can be decreased when combined with Ticlopidine.
NifedipineThe metabolism of Nifedipine can be decreased when combined with Ticlopidine.
NilotinibThe metabolism of Nilotinib can be decreased when combined with Ticlopidine.
NilutamideThe metabolism of Nilutamide can be decreased when combined with Ticlopidine.
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Ticlopidine.
NimesulideNimesulide may increase the anticoagulant activities of Ticlopidine.
NimesulideTiclopidine may increase the antiplatelet activities of Nimesulide.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Ticlopidine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Ticlopidine.
NisoldipineThe metabolism of Nisoldipine can be decreased when combined with Ticlopidine.
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Ticlopidine.
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Ticlopidine.
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Ticlopidine.
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Ticlopidine.
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Ticlopidine.
NorgestrelThe metabolism of Norgestrel can be decreased when combined with Ticlopidine.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Ticlopidine.
ObinutuzumabThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Obinutuzumab.
OlanzapineThe metabolism of Olanzapine can be decreased when combined with Ticlopidine.
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Ticlopidine.
OlaparibThe metabolism of Ticlopidine can be decreased when combined with Olaparib.
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Ticlopidine.
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Ticlopidine.
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Ticlopidine.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Ticlopidine.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Ticlopidine.
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Ticlopidine.
OsimertinibThe serum concentration of Ticlopidine can be increased when it is combined with Osimertinib.
OspemifeneThe metabolism of Ospemifene can be decreased when combined with Ticlopidine.
OtamixabanTiclopidine may increase the anticoagulant activities of Otamixaban.
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Ticlopidine.
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Ticlopidine.
OxazepamThe metabolism of Oxazepam can be decreased when combined with Ticlopidine.
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Ticlopidine.
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Ticlopidine.
OxybutyninThe metabolism of Oxybutynin can be decreased when combined with Ticlopidine.
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Ticlopidine.
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Ticlopidine.
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Ticlopidine.
PalbociclibThe serum concentration of Ticlopidine can be increased when it is combined with Palbociclib.
PalbociclibThe metabolism of Palbociclib can be decreased when combined with Ticlopidine.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Ticlopidine.
PanobinostatThe metabolism of Panobinostat can be decreased when combined with Ticlopidine.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Ticlopidine.
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Ticlopidine.
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Ticlopidine.
ParecoxibThe metabolism of Parecoxib can be decreased when combined with Ticlopidine.
ParicalcitolThe metabolism of Paricalcitol can be decreased when combined with Ticlopidine.
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Ticlopidine.
ParnaparinTiclopidine may increase the anticoagulant activities of Parnaparin.
ParoxetineThe metabolism of Paroxetine can be decreased when combined with Ticlopidine.
PazopanibThe metabolism of Pazopanib can be decreased when combined with Ticlopidine.
Peginterferon alfa-2bThe serum concentration of Ticlopidine can be decreased when it is combined with Peginterferon alfa-2b.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Ticlopidine.
PentobarbitalThe metabolism of Ticlopidine can be increased when combined with Pentobarbital.
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Ticlopidine.
Pentosan PolysulfateTiclopidine may increase the anticoagulant activities of Pentosan Polysulfate.
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Ticlopidine.
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Ticlopidine.
PerampanelThe metabolism of Perampanel can be decreased when combined with Ticlopidine.
PergolideThe metabolism of Pergolide can be decreased when combined with Ticlopidine.
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Ticlopidine.
PermethrinThe metabolism of Permethrin can be decreased when combined with Ticlopidine.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Ticlopidine.
PethidineThe metabolism of Pethidine can be decreased when combined with Ticlopidine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Ticlopidine.
PhenforminThe metabolism of Phenformin can be decreased when combined with Ticlopidine.
PhenindioneTiclopidine may increase the anticoagulant activities of Phenindione.
PhenobarbitalThe metabolism of Ticlopidine can be increased when combined with Phenobarbital.
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Ticlopidine.
PhenprocoumonTiclopidine may increase the anticoagulant activities of Phenprocoumon.
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Ticlopidine.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Ticlopidine.
PhenytoinThe metabolism of Ticlopidine can be increased when combined with Phenytoin.
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Ticlopidine.
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Ticlopidine.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Ticlopidine.
PinacidilThe metabolism of Pinacidil can be decreased when combined with Ticlopidine.
PindololThe metabolism of Pindolol can be decreased when combined with Ticlopidine.
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Ticlopidine.
PiperazineThe metabolism of Piperazine can be decreased when combined with Ticlopidine.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Ticlopidine.
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Ticlopidine.
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Ticlopidine.
PitavastatinThe metabolism of Pitavastatin can be decreased when combined with Ticlopidine.
PlasminTiclopidine may increase the anticoagulant activities of Plasmin.
PodofiloxThe metabolism of Podofilox can be decreased when combined with Ticlopidine.
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Ticlopidine.
PonatinibThe metabolism of Ponatinib can be decreased when combined with Ticlopidine.
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Ticlopidine.
PrasugrelTiclopidine may increase the anticoagulant activities of Prasugrel.
PravastatinThe metabolism of Pravastatin can be decreased when combined with Ticlopidine.
PrazepamThe metabolism of Prazepam can be decreased when combined with Ticlopidine.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Ticlopidine.
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Ticlopidine.
PrednisoneThe metabolism of Prednisone can be decreased when combined with Ticlopidine.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Ticlopidine.
PrimidoneThe metabolism of Ticlopidine can be increased when combined with Primidone.
ProcainamideThe metabolism of Procainamide can be decreased when combined with Ticlopidine.
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Ticlopidine.
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Ticlopidine.
ProguanilThe metabolism of Proguanil can be decreased when combined with Ticlopidine.
PromazineThe metabolism of Promazine can be decreased when combined with Ticlopidine.
PromethazineThe metabolism of Promethazine can be decreased when combined with Ticlopidine.
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Ticlopidine.
PropofolThe metabolism of Propofol can be decreased when combined with Ticlopidine.
PropranololThe metabolism of Propranolol can be decreased when combined with Ticlopidine.
Protein CTiclopidine may increase the anticoagulant activities of Protein C.
ProtocatechualdehydeTiclopidine may increase the anticoagulant activities of Protocatechualdehyde.
ProtriptylineThe metabolism of Protriptyline can be decreased when combined with Ticlopidine.
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Ticlopidine.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Ticlopidine.
QuazepamThe metabolism of Quazepam can be decreased when combined with Ticlopidine.
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Ticlopidine.
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Ticlopidine.
QuinidineThe metabolism of Quinidine can be decreased when combined with Ticlopidine.
QuinineThe metabolism of Quinine can be decreased when combined with Ticlopidine.
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Ticlopidine.
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Ticlopidine.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Ticlopidine.
RanitidineThe metabolism of Ranitidine can be decreased when combined with Ticlopidine.
RanolazineThe metabolism of Ranolazine can be decreased when combined with Ticlopidine.
RasagilineThe metabolism of Rasagiline can be decreased when combined with Ticlopidine.
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Ticlopidine.
RegorafenibThe metabolism of Regorafenib can be decreased when combined with Ticlopidine.
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Ticlopidine.
RepaglinideThe metabolism of Repaglinide can be decreased when combined with Ticlopidine.
repinotanThe metabolism of repinotan can be decreased when combined with Ticlopidine.
ResveratrolResveratrol may increase the anticoagulant activities of Ticlopidine.
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Ticlopidine.
RetapamulinThe metabolism of Retapamulin can be decreased when combined with Ticlopidine.
ReteplaseTiclopidine may increase the anticoagulant activities of Reteplase.
ReviparinTiclopidine may increase the anticoagulant activities of Reviparin.
RidogrelRidogrel may increase the anticoagulant activities of Ticlopidine.
RidogrelTiclopidine may increase the antiplatelet activities of Ridogrel.
RifabutinThe metabolism of Ticlopidine can be increased when combined with Rifabutin.
RifampicinThe metabolism of Ticlopidine can be increased when combined with Rifampicin.
RifapentineThe metabolism of Ticlopidine can be increased when combined with Rifapentine.
RilpivirineThe metabolism of Rilpivirine can be decreased when combined with Ticlopidine.
RiluzoleThe metabolism of Riluzole can be decreased when combined with Ticlopidine.
RimonabantThe metabolism of Rimonabant can be decreased when combined with Ticlopidine.
RiociguatThe metabolism of Riociguat can be decreased when combined with Ticlopidine.
RisperidoneThe metabolism of Risperidone can be decreased when combined with Ticlopidine.
RitonavirThe metabolism of Ritonavir can be decreased when combined with Ticlopidine.
RivaroxabanTiclopidine may increase the anticoagulant activities of Rivaroxaban.
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Ticlopidine.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Ticlopidine.
RolapitantThe metabolism of Rolapitant can be decreased when combined with Ticlopidine.
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Ticlopidine.
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Ticlopidine.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Ticlopidine.
RosiglitazoneTiclopidine may increase the anticoagulant activities of Rosiglitazone.
RosuvastatinThe metabolism of Rosuvastatin can be decreased when combined with Ticlopidine.
RotigotineThe metabolism of Rotigotine can be decreased when combined with Ticlopidine.
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Ticlopidine.
RuxolitinibThe metabolism of Ruxolitinib can be decreased when combined with Ticlopidine.
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Ticlopidine.
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Ticlopidine.
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Ticlopidine.
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Ticlopidine.
SCH-530348SCH-530348 may increase the anticoagulant activities of Ticlopidine.
SCH-530348Ticlopidine may increase the antiplatelet activities of SCH-530348.
SelegilineThe metabolism of Selegiline can be decreased when combined with Ticlopidine.
SelexipagTiclopidine may increase the anticoagulant activities of Selexipag.
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Ticlopidine.
SertindoleThe metabolism of Sertindole can be decreased when combined with Ticlopidine.
SertralineThe metabolism of Sertraline can be decreased when combined with Ticlopidine.
SevofluraneSevoflurane may increase the anticoagulant activities of Ticlopidine.
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Ticlopidine.
SibutramineThe metabolism of Sibutramine can be decreased when combined with Ticlopidine.
SildenafilThe metabolism of Sildenafil can be decreased when combined with Ticlopidine.
SilodosinThe metabolism of Silodosin can be decreased when combined with Ticlopidine.
SiltuximabThe serum concentration of Ticlopidine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Ticlopidine can be increased when it is combined with Simeprevir.
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Ticlopidine.
SirolimusThe metabolism of Sirolimus can be decreased when combined with Ticlopidine.
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Ticlopidine.
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Ticlopidine.
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Ticlopidine.
SonidegibThe metabolism of Sonidegib can be decreased when combined with Ticlopidine.
SorafenibThe metabolism of Sorafenib can be decreased when combined with Ticlopidine.
SparteineThe metabolism of Sparteine can be decreased when combined with Ticlopidine.
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Ticlopidine.
SRT501SRT501 may increase the anticoagulant activities of Ticlopidine.
SRT501Ticlopidine may increase the antiplatelet activities of SRT501.
St. John's WortThe serum concentration of Ticlopidine can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Ticlopidine can be increased when it is combined with Stiripentol.
StreptokinaseTiclopidine may increase the anticoagulant activities of Streptokinase.
SufentanilThe metabolism of Sufentanil can be decreased when combined with Ticlopidine.
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Ticlopidine.
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Ticlopidine.
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Ticlopidine.
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Ticlopidine.
SulfisoxazoleThe metabolism of Ticlopidine can be decreased when combined with Sulfisoxazole.
SulodexideTiclopidine may increase the anticoagulant activities of Sulodexide.
SunitinibThe metabolism of Sunitinib can be decreased when combined with Ticlopidine.
SuprofenThe metabolism of Suprofen can be decreased when combined with Ticlopidine.
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Ticlopidine.
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Ticlopidine.
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Ticlopidine.
TacrineThe metabolism of Tacrine can be decreased when combined with Ticlopidine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Ticlopidine.
TadalafilThe metabolism of Tadalafil can be decreased when combined with Ticlopidine.
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Ticlopidine.
TamsulosinThe metabolism of Tamsulosin can be decreased when combined with Ticlopidine.
TapentadolThe metabolism of Tapentadol can be decreased when combined with Ticlopidine.
TasosartanThe metabolism of Tasosartan can be decreased when combined with Ticlopidine.
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Ticlopidine.
TegaserodThe metabolism of Tegaserod can be decreased when combined with Ticlopidine.
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Ticlopidine.
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Ticlopidine.
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Ticlopidine.
TemazepamThe metabolism of Temazepam can be decreased when combined with Ticlopidine.
TemsirolimusThe metabolism of Temsirolimus can be decreased when combined with Ticlopidine.
TenecteplaseTiclopidine may increase the anticoagulant activities of Tenecteplase.
TeniposideThe metabolism of Teniposide can be decreased when combined with Ticlopidine.
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Ticlopidine.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Ticlopidine.
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Ticlopidine.
TesmilifeneTesmilifene may increase the anticoagulant activities of Ticlopidine.
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Ticlopidine.
TestosteroneThe metabolism of Testosterone can be decreased when combined with Ticlopidine.
TetrabenazineThe metabolism of Tetrabenazine can be decreased when combined with Ticlopidine.
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Ticlopidine.
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Ticlopidine.
TheobromineThe metabolism of Theobromine can be decreased when combined with Ticlopidine.
TheophyllineThe metabolism of Theophylline can be decreased when combined with Ticlopidine.
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Ticlopidine.
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Ticlopidine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Ticlopidine.
ThioridazineThe metabolism of Ticlopidine can be decreased when combined with Thioridazine.
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Ticlopidine.
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Ticlopidine.
TiagabineThe metabolism of Tiagabine can be decreased when combined with Ticlopidine.
TicagrelorTiclopidine may increase the anticoagulant activities of Ticagrelor.
TimololThe metabolism of Timolol can be decreased when combined with Ticlopidine.
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Ticlopidine.
TinzaparinTiclopidine may increase the anticoagulant activities of Tinzaparin.
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Ticlopidine.
TipranavirTipranavir may increase the antiplatelet activities of Ticlopidine.
TipranavirThe metabolism of Tipranavir can be decreased when combined with Ticlopidine.
TirapazamineThe metabolism of Tirapazamine can be decreased when combined with Ticlopidine.
TirofibanTiclopidine may increase the anticoagulant activities of Tirofiban.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Ticlopidine.
TocilizumabThe serum concentration of Ticlopidine can be decreased when it is combined with Tocilizumab.
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Ticlopidine.
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Ticlopidine.
TolterodineThe metabolism of Tolterodine can be decreased when combined with Ticlopidine.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Ticlopidine.
TopiramateThe metabolism of Ticlopidine can be decreased when combined with Topiramate.
TorasemideThe metabolism of Torasemide can be decreased when combined with Ticlopidine.
ToremifeneThe metabolism of Toremifene can be decreased when combined with Ticlopidine.
TositumomabThe risk or severity of adverse effects can be increased when Ticlopidine is combined with Tositumomab.
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Ticlopidine.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Ticlopidine.
TranilastTranilast may increase the anticoagulant activities of Ticlopidine.
TranilastTiclopidine may increase the antiplatelet activities of Tranilast.
TranylcypromineThe metabolism of Ticlopidine can be decreased when combined with Tranylcypromine.
TrapidilTrapidil may increase the anticoagulant activities of Ticlopidine.
TrapidilTiclopidine may increase the antiplatelet activities of Trapidil.
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be decreased when combined with Ticlopidine.
TrazodoneThe metabolism of Trazodone can be decreased when combined with Ticlopidine.
TreprostinilTiclopidine may increase the anticoagulant activities of Treprostinil.
TreprostinilTreprostinil may increase the antiplatelet activities of Ticlopidine.
TretinoinThe metabolism of Tretinoin can be decreased when combined with Ticlopidine.
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Ticlopidine.
TriamtereneThe metabolism of Triamterene can be decreased when combined with Ticlopidine.
TriazolamThe metabolism of Triazolam can be decreased when combined with Ticlopidine.
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Ticlopidine.
TriflusalTiclopidine may increase the anticoagulant activities of Triflusal.
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Ticlopidine.
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Ticlopidine.
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Ticlopidine.
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Ticlopidine.
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Ticlopidine.
UdenafilThe metabolism of Udenafil can be decreased when combined with Ticlopidine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Ticlopidine.
UmeclidiniumThe metabolism of Umeclidinium can be decreased when combined with Ticlopidine.
UrokinaseTiclopidine may increase the anticoagulant activities of Urokinase.
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Ticlopidine.
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Ticlopidine.
ValsartanThe metabolism of Valsartan can be decreased when combined with Ticlopidine.
VandetanibThe metabolism of Vandetanib can be decreased when combined with Ticlopidine.
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Ticlopidine.
VardenafilThe metabolism of Vardenafil can be decreased when combined with Ticlopidine.
VemurafenibThe metabolism of Vemurafenib can be decreased when combined with Ticlopidine.
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Ticlopidine.
VerapamilThe metabolism of Verapamil can be decreased when combined with Ticlopidine.
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Ticlopidine.
VilanterolThe metabolism of Vilanterol can be decreased when combined with Ticlopidine.
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Ticlopidine.
VinblastineThe metabolism of Vinblastine can be decreased when combined with Ticlopidine.
VincristineThe metabolism of Vincristine can be decreased when combined with Ticlopidine.
VindesineThe serum concentration of Vindesine can be increased when it is combined with Ticlopidine.
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Ticlopidine.
VismodegibThe metabolism of Vismodegib can be decreased when combined with Ticlopidine.
Vitamin EVitamin E may increase the antiplatelet activities of Ticlopidine.
VorapaxarTiclopidine may increase the anticoagulant activities of Vorapaxar.
VoriconazoleThe metabolism of Voriconazole can be decreased when combined with Ticlopidine.
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Ticlopidine.
WarfarinTiclopidine may increase the anticoagulant activities of Warfarin.
XimelagatranTiclopidine may increase the anticoagulant activities of Ximelagatran.
YohimbineThe metabolism of Yohimbine can be decreased when combined with Ticlopidine.
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Ticlopidine.
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Ticlopidine.
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Ticlopidine.
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Ticlopidine.
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Ticlopidine.
ZileutonThe metabolism of Zileuton can be decreased when combined with Ticlopidine.
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Ticlopidine.
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Ticlopidine.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Ticlopidine.
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Ticlopidine.
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Ticlopidine.
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Ticlopidine.
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Ticlopidine.
Food Interactions
  • High fat meals will increase ticlopidine absorption. As well, food can help ticlopidine-induced stomach upset.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Guanyl-nucleotide exchange factor activity
Specific Function:
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation.
Gene Name:
P2RY12
Uniprot ID:
Q9H244
Molecular Weight:
39438.355 Da
References
  1. Storey RF: The P2Y12 receptor as a therapeutic target in cardiovascular disease. Platelets. 2001 Jun;12(4):197-209. [PubMed:11454254 ]
  2. Boeynaems JM, van Giezen H, Savi P, Herbert JM: P2Y receptor antagonists in thrombosis. Curr Opin Investig Drugs. 2005 Mar;6(3):275-82. [PubMed:15816504 ]
  3. Gachet C: The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Ther. 2005 Nov;108(2):180-92. Epub 2005 Jun 13. [PubMed:15955565 ]
  4. Zhan C, Yang J, Dong XC, Wang YL: Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists. J Mol Graph Model. 2007 Jul;26(1):20-31. Epub 2006 Sep 26. [PubMed:17110146 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Peroxidase activity
Specific Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Gene Name:
MPO
Uniprot ID:
P05164
Molecular Weight:
83867.71 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. [PubMed:17101742 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23