Sucralfate

Identification

Summary

Sucralfate is a gastro-duodenal protective agent used in the treatment of gastric and duodenal ulcers and to prevent duodenal ulcer recurrence.

Brand Names
Carafate, Sulcrate
Generic Name
Sucralfate
DrugBank Accession Number
DB00364
Background

Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers Label, gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia 2. It is considered a cytoprotective agent, protecting cells in the gastrointestinal tract from damage caused by agents such as gastric acid, bile salts, alcohol, and acetylsalicylic acid (aspirin), among other substances 2,13.

Sucralfate has been shown to be a well-tolerated and safe drug. It is sold under many brands and is available in both tablet and suspension forms. It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form 11,12.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 1558.67
Monoisotopic: 1557.6045961
Chemical Formula
C12H35Al9O55S8
Synonyms
  • Hexadeca-μ-hydroxytetracosahydroxy[μ8-[1,3,4,6-tetra-O-sulfo-β-Dfructofuranosyl-α-D-glucopyranoside tetrakis(hydrogen sulfato)8-)]]hexadecaaluminum
  • Sucralfat
  • Sucralfate
  • Sucralfato
  • Sucralfatum
External IDs
  • CGA-6J
  • OS 202

Pharmacology

Indication

The sucralfate suspension Label and tablet 15 are used for the treatment of active duodenal ulcer for up to 8 weeks. The tablet form may be used at a lower dose for healed duodenal ulcers, for the purpose of maintaining healing and preventing recurrence 13,15.

Sucralfate is also used in the prevention and/or treatment of gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia 2,13.

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to treatDyspepsia••• •••••
Prevention ofGerd (gastroesophageal reflux disease)••• •••••
Used in combination to treatGerd (gastroesophageal reflux disease)••• •••••
Treatment ofGastric ulcer••• •••••
Prevention ofGastritis••• •••••
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

This drug aids in the healing of duodenal ulcers, relieving painful inflammation by creating a protective mechanical barrier between the lining or skin of the gastrointestinal tract and damaging substances 2. In addition, sucralfate acts to increase levels of growth factors locally, and also causes an increase in prostaglandins which are important in the healing of the mucosa (lining) of the gastrointestinal tract 2.

Mechanism of action

The mechanism of action of this drug in the healing duodenal ulcers is not yet completely defined, however, there are several probable mechanisms that adequately describe the healing activity of sucralfate. There is evidence that sucralfate acts locally to aid in tissue healing, and not systemically Label.

Studies in both humans and animals have indicated that sucralfate forms a complex that binds to protein-rich exudate found on the surface of ulcers. It binds to albumin and fibrinogen 7,8 preventing blood clot lysis by stomach acid (hydrochloric acid). Sucralfate increases the tissue levels of fibroblast growth factors and epidermal growth factors,5,6 leading to an increase in prostaglandins at the gastrointestinal tract lining, which promotes the healing of gastrointestinal ulcers.2

In the laboratory setting, a sucralfate-albumin film provides a barrier against the entry of hydrogen ions, which are a component of gastric acid. In humans, sucralfate, given at therapeutic doses for ulcers, decreases pepsin activity in gastric fluids by 32% Label. Pepsin has been shown to be damaging to tissues, further aggravating ulcer lesion inflammation 4. Bile salts have been implicated in mucosal injury to the gastrointestinal tract 9,10. Sucralfate has also been shown to adsorb bile salts in the laboratory, setting, which could further contribute to its beneficial effects in ulcer healing Label.

TargetActionsOrganism
APepsin A-5
inhibitor
Humans
AFibroblast growth factor 2
agonist
inducer
Humans
APro-epidermal growth factor
inducer
Humans
UFibrinogen
binder
Humans
Absorption

This drug is absorbed from the gastrointestinal tract in very minimal quantities.Label The adsorbed sulfated disaccharide is excreted in the urine 13. This drug contains aluminum and after the administration of 1 g of sucralfate 4 times per day, about 0.001% to 0.017% of this aluminum content is absorbed in patients with normal renal function.13 This number is expected to increase in those with impaired renal function.13

Volume of distribution

This drug is absorbed in a very small quantity, and normally localizes to inflamed gastrointestinal lesions Label.

Protein binding

Sucralfate is bound to plasma proteins, especially albumin and transferrin 13.

Metabolism

This drug is absorbed in very small quantities and is not significantly metabolized Label,13.

Route of elimination

The negligible amount of this drug that is absorbed is excreted mainly in the urine within 48 hours Label,16.

Half-life

The half-life is not known. In animals, the elimination half-life of the sucrose component of this drug is from 6-20 h 16.

Clearance

Sucralfate contains aluminum. The administration of sucralfate in non-dialyzed chronic renal failure patients warrants careful consideration from the treating physician as the excretion of absorbed aluminum may be decreased, causing possible aluminum toxicity 13.

In dialyzed patients diagnosed with chronic renal failure, aluminum toxicity related to sucralfate has been observed and reported. The daily amount of aluminum ingestion (including sucralfate) should be carefully examined before administering sucralfate in combination with other drugs also containing aluminum, including various antacids 13.

Adverse Effects
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Toxicity

Overdose

Overdosage has never been observed with sucralfate 13. It is unlikely, as administering a maximum dose of up to 12 g/kg/body weight in several animal species did not result in death. The lethal dose could not be determined in these studies 13. It is likely that overdose of sucralfate in humans would result in constipation, and supportive treatment would be advised 13.

Use in pregnancy

This drug is considered a pregnancy Category B drug. Studies have been performed in rodents and rabbits at doses up to 50 times the recommended human dose. No harm to the fetus has been observed in the abovementioned studies. Sufficient and well-controlled clinical trials have not been performed in pregnant women. Due to the fact that the results of animal studies are not always relevant to human response, sucralfate should be used during pregnancy only if it is deemed essential for the mother's health Label.

Use in nursing

Whether this drug is excreted in human milk is currently unknown. Many drugs are excreted in breast milk, therefore, if sucralfate is administered to a lactating and nursing woman, caution should be observed Label.

Carcinogenesis

24 month toxicity studies were performed in rodents, and the dose of sucralfate reached up to 1 g/kg (equivalent to 12 times the recommended human dose). No signs of sucralfate-related tumors were notedLabel.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirSucralfate may decrease the excretion rate of Abacavir which could result in a higher serum level.
AceclofenacAceclofenac may decrease the excretion rate of Sucralfate which could result in a higher serum level.
AcemetacinAcemetacin may decrease the excretion rate of Sucralfate which could result in a higher serum level.
AcenocoumarolThe therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Sucralfate.
AcetaminophenAcetaminophen may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Food Interactions
  • Take on an empty stomach. Take at least 1 hour before or 2 hours after meals.
  • Take separate from antacids. Take at least 30 minutes before or after antacids.

Products

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Product Images
International/Other Brands
Antepsin (Orion) / Sucramal (Menarini) / Sucraxol (Medifarma) / Ulcogant (Merck)
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
CarafateSuspension1 g/10mLOralAtlantic Biologicals Corp.1993-12-16Not applicableUS flag
CarafateSuspension1 g/10mLOralPhysicians Total Care, Inc.1996-03-12Not applicableUS flag
CarafateTablet1 g/1OralAllergan, Inc.1981-10-30Not applicableUS flag
CarafateSuspension1 g/10mLOralAllergan, Inc.1993-12-16Not applicableUS flag
SucralfateSuspension1 g/10mLOralNatco Pharma USA LLC2021-01-27Not applicableUS flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Apo-sucralfate - Tab 1gTablet1 gOralApotex Corporation1994-12-31Not applicableCanada flag
Dom-sucralfateTablet1000 mgOralDominion Pharmacal1999-09-152016-10-25Canada flag
Nu-sucralfate - Tab 1gmTablet1 gOralNu Pharm Inc1994-12-312012-09-04Canada flag
PMS-sucralfateTablet1 gOralPharmascience Inc1999-02-23Not applicableCanada flag
SucralfateTablet1 g/1Oralbryant ranch prepack2020-02-17Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
APO-SUCRALFATE TABLET 1 gTablet1 gOralPHARMAFORTE SINGAPORE PTE LTD1996-02-27Not applicableSingapore flag
SUCRALTablet500 mgOralบริษัท โอลิค (ประเทศไทย) จำกัด1998-12-04Not applicableThailand flag
ซูคราเฟนTablet1000 mgOralห้างหุ้นส่วนจำกัด โรงงานเลิศสิงห์เภสัชกรรม1995-08-16Not applicableThailand flag
ซูเครทเจลSuspension1000 mg/5mlOralบริษัท นีโอ ฟาร์ม จำกัด จำกัด2007-11-29Not applicableThailand flag
อัลซีเฟต ชนิดยาน้ำแขวนตะกอนSuspension1000 mg/5mlOralบริษัท สยามเภสัช จำกัด1990-08-17Not applicableThailand flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Varecell Intensive Liposome DoubleCreamSucralfate (0.18 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL)CreamTopicalD&S Cosmedique Co.Ltd.2021-09-07Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Varecell Intensive Liposome DoubleCreamSucralfate (0.18 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL)CreamTopicalD&S Cosmedique Co.Ltd.2021-09-07Not applicableUS flag

Categories

ATC Codes
A02BX02 — Sucralfate
Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
XX73205DH5
CAS number
54182-58-0
InChI Key
IPLJAZDIICJQEL-JTJNLBSYSA-A
InChI
InChI=1S/C12H22O35S8.9Al.20H2O/c13-48(14,15)37-1-4-6(43-51(22,23)24)8(45-53(28,29)30)9(46-54(31,32)33)11(40-4)42-12(3-39-50(19,20)21)10(47-55(34,35)36)7(44-52(25,26)27)5(41-12)2-38-49(16,17)18;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/h4-11H,1-3H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;;;;;;;;;20*1H2/q;9*+3;;;;;;;;;;;;;;;;;;;;/p-27/t4-,5-,6-,7-,8+,9-,10+,11-,12+;;;;;;;;;;;;;;;;;;;;;;;;;;;;;/m1............................./s1
IUPAC Name
[({[(2R,3R,4S,5R,6R)-6-{[(2S,3S,4R,5R)-3,4-bis({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)-2,5-bis[({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)methyl]oxolan-2-yl]oxy}-4,5-bis({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)-2-[({[(dihydroxyalumanyl)oxy]sulfonyl}oxy)methyl]oxan-3-yl]oxy}sulfonyl)oxy]alumanediol alumanetriol hydrate
SMILES
O.O[Al](O)O.O[Al](O)OS(=O)(=O)OC[C@H]1O[C@@](COS(=O)(=O)O[Al](O)O)(O[C@H]2O[C@H](COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@H]2OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@@H]1OS(=O)(=O)O[Al](O)O

References

Synthesis Reference

Nick V. Lazaridis, Moo K. Park, Yousry Sayed, "Method for preparing high potency sucralfate." U.S. Patent US4990610, issued March, 1973.

US4990610
General References
  1. Rees WD: Mechanisms of gastroduodenal protection by sucralfate. Am J Med. 1991 Aug 8;91(2A):58S-63S. [Article]
  2. Candelli M, Carloni E, Armuzzi A, Cammarota G, Ojetti V, Pignataro G, Santoliquido A, Pola R, Pola E, Gasbarrini G, Gasbarrini A: Role of sucralfate in gastrointestinal diseases. Panminerva Med. 2000 Mar;42(1):55-9. [Article]
  3. Lam SK: Why do ulcers heal with sucralfate? Scand J Gastroenterol Suppl. 1990;173:6-16. [Article]
  4. Bardhan KD, Strugala V, Dettmar PW: Reflux revisited: advancing the role of pepsin. Int J Otolaryngol. 2012;2012:646901. doi: 10.1155/2012/646901. Epub 2011 Nov 10. [Article]
  5. Szabo S: The mode of action of sucralfate: the 1 x 1 x 1 mechanism of action. Scand J Gastroenterol Suppl. 1991;185:7-12. [Article]
  6. Korman MG, Bolin TD, Szabo S, Hunt RH, Marks IN, Glise H: Sucralfate: the Bangkok review. J Gastroenterol Hepatol. 1994 Jul-Aug;9(4):412-5. [Article]
  7. Terao N, Yoshida N, Nagashima R: Sucralfate, a basic aluminum salt of sucrose sulfate. III. Inhibition of peptic hydrolysis of fibrinogen by sucrose sulfate. Arzneimittelforschung. 1980;30(1):76-8. [Article]
  8. Patchett SE, Enright H, Afdhal N, O'Connell W, O'Donoghue DP: Clot lysis by gastric juice: an in vitro study. Gut. 1989 Dec;30(12):1704-7. [Article]
  9. Gadacz TR, Zuidema GD: Bile acid composition in patients with and without symptoms of postoperative refulx gastritis. Am J Surg. 1978 Jan;135(1):48-52. [Article]
  10. Duane WC, Wiegand DM: Mechanism by which bile salt disrupts the gastric mucosal barrier in the dog. J Clin Invest. 1980 Nov;66(5):1044-9. doi: 10.1172/JCI109932. [Article]
  11. FDA approval, Sucralfate suspension [Link]
  12. Sucralfate tablet FDA approval [Link]
  13. Product monograph, Sulcrate [File]
  14. MedSafe NZ, Sucralfate [File]
  15. Sucralfate FDA label, tablet form [File]
  16. Risk profile of sucralfate [File]
Human Metabolome Database
HMDB0014508
KEGG Compound
C07314
PubChem Compound
70789197
PubChem Substance
46508862
ChemSpider
32701653
RxNav
10156
ChEMBL
CHEMBL2029132
PharmGKB
PA451524
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
PDRhealth
PDRhealth Drug Page
Wikipedia
Sucralfate
FDA label
Download (217 KB)
MSDS
Download (73.6 KB)

Clinical Trials

Clinical Trials

Pharmacoeconomics

Manufacturers
  • Axcan pharma us inc
  • Nostrum laboratories inc
  • Teva pharmaceuticals usa inc
Packagers
  • Amerisource Health Services Corp.
  • Amneal Pharmaceuticals
  • A-S Medication Solutions LLC
  • Axcan Pharma Inc.
  • Bryant Ranch Prepack
  • Cardinal Health
  • Caremark LLC
  • Dept Health Central Pharmacy
  • Direct Dispensing Inc.
  • Diversified Healthcare Services Inc.
  • Eon Labs
  • Giant Food Inc.
  • Golden State Medical Supply Inc.
  • H.J. Harkins Co. Inc.
  • Heartland Repack Services LLC
  • Ivax Pharmaceuticals
  • Levista Inc.
  • Long Wing International Inc.
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Medisca Inc.
  • Merckle GmbH
  • Murfreesboro Pharmaceutical Nursing Supply
  • Nostrum Laboratories Inc.
  • Nucare Pharmaceuticals Inc.
  • PD-Rx Pharmaceuticals Inc.
  • Pharmaceutical Association
  • Pharmaceutical Utilization Management Program VA Inc.
  • Pharmedix
  • Physicians Total Care Inc.
  • Prasco Labs
  • Precision Dose Inc.
  • Prepak Systems Inc.
  • Prescript Pharmaceuticals
  • Prime European Therapeuticals SPA
  • Qingdao Pana Life Biochem Co. Ltd.
  • Resource Optimization and Innovation LLC
  • Sandhills Packaging Inc.
  • Sanofi-Aventis Inc.
  • Stat Rx Usa
  • Teva Pharmaceutical Industries Ltd.
  • UDL Laboratories
  • Vangard Labs Inc.
  • Vistapharm Inc.
  • Warrick Pharmaceuticals Corp.
  • Watson Pharmaceuticals
  • Xactdose Inc.
Dosage Forms
FormRouteStrength
TabletOral1000.00 mg
Tablet, chewableBuccal500 mg
PowderOral1 G
PowderOral2 G
SuspensionOral20 %
Tablet, solubleOral1000 mg
SuspensionOral1 g/5ml
TabletOral1 g
Tablet, coatedOral
GelOral
Granule, for suspensionOral1 g
Granule, for suspensionOral2 G
Tablet, chewableOral1 G
SuspensionOral2000000 g
Tablet, chewableOral1000 mg
TabletOral1.000 g
SuspensionOral500 MG/5ML
SuspensionOral500 MG
TabletOral1000.000 mg
TabletOral
SuspensionOral1000.00 mg
TabletOral1.0 g
TabletOral500 mg
SuspensionOral
SuspensionOral1 g/10mL
TabletOral1 g/1
PowderNot applicable1 kg/1kg
TabletOral1.11 mg
SuspensionOral20 g
Powder, for suspensionOral1 G
Powder, for suspensionOral2 G
Powder, for suspensionOral
GranuleOral1 g
GelOral1 G/5ML
GelOral2 G/10ML
Granule, for solutionOral1 g
Granule, for suspensionOral
Tablet, chewableOral
Tablet, coatedOral1000 mg
SuspensionOral100 mg / mL
SuspensionOral1 g / 5 mL
GranuleOral
TabletOral
TabletOral1.0000 g
SuspensionOral20.000 g
TabletOral1062.500 mg
CreamTopical
TabletOral1000 mg
SuspensionOral1000 mg/5ml
Tablet, chewableOral500 mg
Prices
Unit descriptionCostUnit
Sucralfate 1 gm/10ml Suspension 10ml Cup13.99USD cup
Carafate 1 gm tablet1.45USD tablet
Sucralfate 1 gm tablet0.72USD tablet
Sucralfate powder0.6USD g
Sulcrate 1 g Tablet0.59USD tablet
Apo-Sucralfate 1 g Tablet0.31USD tablet
Novo-Sucralate 1 g Tablet0.31USD tablet
Nu-Sucralfate 1 g Tablet0.31USD tablet
Pms-Sucralfate 1 g Tablet0.31USD tablet
Carafate 1 gm/10ml Suspension0.24USD ml
Sulcrate Suspension Plus 200 mg/ml Suspension0.11USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)>220https://www.trc-canada.com/product-detail/?S692350
water solubilityInsolublehttps://www.chemicalbook.com/ChemicalProductProperty_US_CB6239042.aspx
logP-7.087http://www.molbase.com/en/overview_54182-58-0-moldata-62765.html
pKa 0.43 to 1.19https://www.chemicalbook.com/ChemicalProductProperty_US_CB6239042.aspx
Predicted Properties
PropertyValueSource
Water Solubility0.774 mg/mLALOGPS
logP0.74ALOGPS
logP-5.9Chemaxon
logS-3.3ALOGPS
pKa (Strongest Acidic)13.53Chemaxon
pKa (Strongest Basic)-3Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count35Chemaxon
Hydrogen Donor Count16Chemaxon
Polar Surface Area772.17 Å2Chemaxon
Rotatable Bond Count37Chemaxon
Refractivity180.03 m3·mol-1Chemaxon
Polarizability107.19 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption-0.7959
Blood Brain Barrier+0.8803
Caco-2 permeable-0.6433
P-glycoprotein substrateNon-substrate0.8087
P-glycoprotein inhibitor INon-inhibitor0.5656
P-glycoprotein inhibitor IINon-inhibitor0.986
Renal organic cation transporterNon-inhibitor0.8471
CYP450 2C9 substrateNon-substrate0.8611
CYP450 2D6 substrateNon-substrate0.8256
CYP450 3A4 substrateNon-substrate0.6233
CYP450 1A2 substrateNon-inhibitor0.772
CYP450 2C9 inhibitorNon-inhibitor0.8211
CYP450 2D6 inhibitorNon-inhibitor0.8865
CYP450 2C19 inhibitorNon-inhibitor0.7869
CYP450 3A4 inhibitorNon-inhibitor0.9828
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9328
Ames testNon AMES toxic0.5805
CarcinogenicityNon-carcinogens0.5356
BiodegradationNot ready biodegradable0.8432
Rat acute toxicity2.4219 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7937
hERG inhibition (predictor II)Non-inhibitor0.8793
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Inhibitor
General Function
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Specific Function
Aspartic-type endopeptidase activity
Gene Name
PGA5
Uniprot ID
P0DJD9
Uniprot Name
Pepsin A-5
Molecular Weight
41992.845 Da
References
  1. Jensen SL, Funch Jensen P: Role of sucralfate in peptic disease. Dig Dis. 1992;10(3):153-61. [Article]
  2. Hollander D, Tarnawski A: The protective and therapeutic mechanisms of sucralfate. Scand J Gastroenterol Suppl. 1990;173:1-5. [Article]
  3. Peterson WL: Pathogenesis and therapy of peptic ulcer disease. J Clin Gastroenterol. 1990;12 Suppl 2:S1-6. [Article]
  4. Kegg [Link]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Agonist
Inducer
General Function
Ligand-dependent nuclear receptor transcription coactivator activity
Specific Function
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Gene Name
FGF2
Uniprot ID
P09038
Uniprot Name
Fibroblast growth factor 2
Molecular Weight
30769.715 Da
References
  1. Szabo S: The mode of action of sucralfate: the 1 x 1 x 1 mechanism of action. Scand J Gastroenterol Suppl. 1991;185:7-12. [Article]
  2. Tarnawski A, Tanoue K, Santos AM, Sarfeh IJ: Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? Scand J Gastroenterol Suppl. 1995;210:9-14. [Article]
  3. Szabo S, Kusstatscher S, Sakoulas G, Sandor Z, Vincze A, Jadus M: Growth factors: new 'endogenous drugs' for ulcer healing. Scand J Gastroenterol Suppl. 1995;210:15-8. [Article]
  4. Korman MG, Bolin TD, Szabo S, Hunt RH, Marks IN, Glise H: Sucralfate: the Bangkok review. J Gastroenterol Hepatol. 1994 Jul-Aug;9(4):412-5. [Article]
Kind
Protein
Organism
Humans
Pharmacological action
Yes
Actions
Inducer
General Function
Transmembrane receptor protein tyrosine kinase activator activity
Specific Function
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in ...
Gene Name
EGF
Uniprot ID
P01133
Uniprot Name
Pro-epidermal growth factor
Molecular Weight
133993.12 Da
References
  1. Tarnawski A, Tanoue K, Santos AM, Sarfeh IJ: Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? Scand J Gastroenterol Suppl. 1995;210:9-14. [Article]
  2. Szabo S: The mode of action of sucralfate: the 1 x 1 x 1 mechanism of action. Scand J Gastroenterol Suppl. 1991;185:7-12. [Article]
  3. Konturek SJ: Role of growth factors in gastroduodenal protection and healing of peptic ulcers. Gastroenterol Clin North Am. 1990 Mar;19(1):41-65. [Article]
4. Fibrinogen
Kind
Group
Organism
Humans
Pharmacological action
Unknown
Actions
Binder
This group includes the fibrinogen alpha chain, beta chain, and gamma chain.
References
  1. Terao N, Yoshida N, Nagashima R: Sucralfate, a basic aluminum salt of sucrose sulfate. III. Inhibition of peptic hydrolysis of fibrinogen by sucrose sulfate. Arzneimittelforschung. 1980;30(1):76-8. [Article]
  2. Patchett SE, Enright H, Afdhal N, O'Connell W, O'Donoghue DP: Clot lysis by gastric juice: an in vitro study. Gut. 1989 Dec;30(12):1704-7. [Article]
  3. Sucralfate - Drug Summary [Link]

Drug created at June 13, 2005 13:24 / Updated at March 18, 2024 16:48