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Identification
NameLevothyroxine
Accession NumberDB00451  (APRD00235, EXPT02993)
TypeSmall Molecule
GroupsApproved
Description

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]

Structure
Thumb
Synonyms
3,3',5,5'-Tetraiodo-L-thyronine
3,5,3',5'-TETRAIODO-L-thyronine
4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine
L-T4
L-Thyroxine
Levothyroxin
LT4
O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine
O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
T4
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Eltroxintablet200 mcgoralAspen Pharma Trading Limited1997-04-02Not applicableCanada
Eltroxintablet150 mcgoralAspen Pharma Trading Limited1974-12-31Not applicableCanada
Eltroxintablet300 mcgoralAspen Pharma Trading Limited1998-02-11Not applicableCanada
Eltroxintablet100 mcgoralAspen Pharma Trading Limited1998-11-27Not applicableCanada
Eltroxintablet50 mcgoralAspen Pharma Trading Limited1951-12-30Not applicableCanada
Eltroxin 150 Tabtablet150 mcgoralGlaxo Canada Inc1974-12-311999-08-12Canada
Eltroxin Tab 100mcgtablet.1 mgoralGlaxo Canada Inc1951-12-311999-08-12Canada
Eltroxin Tab 200mcgtablet.2 mgoralGlaxo Canada Inc1960-12-311998-07-30Canada
Eltroxin Tab 300mcgtablet.3 mgoralGlaxo Canada Inc1966-12-311998-07-30Canada
Eltroxin Tab 50mcgtablet.05 mgoralGlaxo Canada Inc1951-12-311998-07-30Canada
Euthyroxtablet175 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet50 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet200 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet150 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet25 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet137 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet125 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet112 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet100 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet88 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet75 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Euthyroxtablet300 mcgoralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Levo-Ttablet88 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet100 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet300 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet75 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet50 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet200 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet25 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet175 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet150 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet137 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet125 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-Ttablet112 ug/1oralNeolpharma, Inc.2015-10-292016-04-05Us
Levo-T 100mcg - Tabtablet100 mcgoralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 125mcg - Tabtablet125 mcgoralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 150mcg - Tabtablet150 mcgoralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 200mcg - Tabtablet200 mcgoralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 25mcg - Tabtablet25 mcgoralPharmascience Inc1996-07-302006-06-08Canada
Levo-T 300mcg - Tabtablet300 mcgoralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 50mcg - Tabtablet50 mcgoralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 75mcg - Tabtablet75 mcgoralPharmascience Inc1996-06-272006-06-08Canada
Levotec 100mcg Tablets USPtablet100 mcgoralTechnilab Pharma Inc.1998-09-082004-07-22Canada
Levotec 112mcg Tablets USPtablet112 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 125mcg Tablets USPtablet125 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 150mcg Tablets USPtablet150 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 175mcg Tablets USPtablet175 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 200mcg Tablets USPtablet200 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 25mcg Tablets USPtablet25 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 300mcg Tablets USPtablet300 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 50mcg Tablets USPtablet50 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 75mcg Tablets USPtablet75 mcgoralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levothroidtablet200 ug/1oralPhysicians Total Care, Inc.2005-05-202016-04-05Us
Levothroidtablet175 ug/1oralPhysicians Total Care, Inc.2003-09-122016-04-05Us
Levothroidtablet150 ug/1oralPhysicians Total Care, Inc.2002-03-082016-04-05Us
Levothyroxinetablet25 ug/1oralNorthwind Pharmaceuticals, LLC2014-07-102016-04-05Us
Levothyroxinetablet125 ug/1oralNorthwind Pharmaceuticals, LLC2014-09-142016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralLannett Company, Inc.2007-10-012016-04-23Us
Levothyroxine Sodiumtablet.1 mg/1oralSTAT Rx USA LLC2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralREMEDYREPACK INC.2013-02-162016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralBlenheim Pharmacal, Inc.2013-11-152016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralRebel Distributors Corp.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet200 ug/1oralLake Erie Medical DBA Quality Care Products LLC2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralSt Marys Medical Park Pharmacy2013-05-162016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralbryant ranch prepack2007-10-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralbryant ranch prepack2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralPreferred Pharmaceuticals, Inc.2014-10-132016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet88 ug/1oralLake Erie Medical DBA Quality Care Products LLC2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralREMEDYREPACK INC.2011-12-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralREMEDYREPACK INC.2013-08-272016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralREMEDYREPACK INC.2011-07-282016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet.1 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralDispensing Solutions, Inc.2007-10-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralREMEDYREPACK INC.2011-12-282016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralNorthwind Pharmaceuticals, LLC2015-02-032016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralUnit Dose Services2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralH.J. Harkins Company, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralNorthwind Pharmaceuticals, LLC2014-07-312016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet112 ug/1oralREMEDYREPACK INC.2013-07-082016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralBlenheim Pharmacal, Inc.2013-11-152016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralDispensing Solutions, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet125 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralRebel Distributors Corp2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralSt Marys Medical Park Pharmacy2013-07-112016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralbryant ranch prepack2003-12-012016-04-05Us
Levothyroxine Sodiumtablet88 ug/1oralbryant ranch prepack2011-05-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralLake Erie Medical DBA Quality Care Products LLC2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralREMEDYREPACK INC.2011-11-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralREMEDYREPACK INC.2011-07-222016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet.088 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralDispensing Solutions, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralNorthwind Pharmaceuticals2014-12-232016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralUnit Dose Services2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralH.J. Harkins Company, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet50 ug/1oralREMEDYREPACK INC.2013-07-082016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralBlenheim Pharmacal, Inc.2012-02-132016-04-05Us
Levothyroxine Sodiumtablet112 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralRebel Distributors Corp.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralBlenheim Pharmacal, Inc.2013-11-182016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralREMEDYREPACK INC.2013-04-102016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralbryant ranch prepack2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet112 ug/1oralLake Erie Medical DBA Quality Care Products LLC2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralREMEDYREPACK INC.2011-10-312016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralREMEDYREPACK INC.2011-07-152016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralProficient Rx LP2007-10-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet.075 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiuminjection, powder, lyophilized, for solution100 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-242016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralNorthwind Pharmaceuticals2014-12-172016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralUnit Dose Services2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralREMEDYREPACK INC.2014-02-032016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralREMEDYREPACK INC.2013-08-132016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralBlenheim Pharmacal, Inc.2010-12-202016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralRebel Distributors Corp2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralBlenheim Pharmacal, Inc.2013-11-182016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralSt Marys Medical Park Pharmacy2013-07-112016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralDispensing Solutions, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralREMEDYREPACK INC.2011-12-082016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralREMEDYREPACK INC.2011-07-142016-04-05Us
Levothyroxine Sodiumtablet.3 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet.05 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiuminjection, powder, lyophilized, for solution500 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-242016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralNorthwind Pharmaceuticals, LLC2014-11-252016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralUnit Dose Services2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.3 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet150 ug/1oralREMEDYREPACK INC.2013-11-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralREMEDYREPACK INC.2013-08-272016-04-05Us
Levothyroxine Sodiumtablet137 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet88 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralRebel Distributors Corp.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralBlenheim Pharmacal, Inc.2013-11-182016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralSt Marys Medical Park Pharmacy2013-05-162016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralbryant ranch prepack2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-10-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralREMEDYREPACK INC.2011-12-072016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralREMEDYREPACK INC.2011-07-132016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet.025 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiuminjection, powder, lyophilized, for solution200 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-242016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralNorthwind Pharmaceuticals, LLC2014-11-032016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralUnit Dose Services2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet125 ug/1oralREMEDYREPACK INC.2013-09-242016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralREMEDYREPACK INC.2013-05-062016-04-05Us
Levothyroxine Sodiumtablet300 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralRebel Distributors Corp.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralBlenheim Pharmacal, Inc.2013-11-182016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralRebel Distributors Corp.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralSt Marys Medical Park Pharmacy2013-05-162016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralbryant ranch prepack2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet125 ug/1oralAidarex Pharmaceuticals LLC2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralREMEDYREPACK INC.2011-10-212016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralREMEDYREPACK INC.2011-07-142016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralUnit Dose Services2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralUnit Dose Services2007-10-012016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralPreferred Pharmaceuticals Inc.2016-03-142016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet.112 mg/1oralREMEDYREPACK INC.2013-08-132016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralREMEDYREPACK INC.2013-02-192016-04-05Us
Levothyroxine Sodiumtablet200 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralState of Florida DOH Central Pharmacy2013-01-012016-04-05Us
Levothyroxine Sodiumtablet50 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralRebel Distributors Corp.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralBlenheim Pharmacal, Inc.2013-11-182016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralRebel Distributors Corp2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralSt Marys Medical Park Pharmacy2013-07-112016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralbryant ranch prepack2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet50 ug/1oralPreferred Pharmaceuticals, Inc.2014-10-132016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet175 ug/1oralLake Erie Medical DBA Quality Care Products LLC2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-032016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralUnit Dose Services2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralNorthwind Pharmaceuticals2014-12-172016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet.075 mg/1oralREMEDYREPACK INC.2013-08-132016-04-05Us
Levothyroxine Sodiumtablet175 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralSTAT Rx USA LLC2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.088 mg/1oralBlenheim Pharmacal, Inc.2013-11-182016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralPd Rx Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralRebel Distributors Corp.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralSt Marys Medical Park Pharmacy2013-05-162016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralSt Marys Medical Park Pharmacy2014-04-092016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralbryant ranch prepack2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralPreferred Pharmaceuticals, Inc.2009-09-092016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralPreferred Pharmaceuticals, Inc.2014-10-132016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralREMEDYREPACK INC.2011-09-272016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralREMEDYREPACK INC.2011-08-102016-04-05Us
Levothyroxine Sodiumtablet50 ug/1oralMedsource Pharmaceuticals2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralLannett Company, Inc.2003-12-012016-04-23Us
Levothyroxine Sodiumtablet.025 mg/1oralREMEDYREPACK INC.2013-08-132016-04-05Us
Levothyroxine Sodiumtablet150 ug/1oralSandoz Inc.2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralSTAT Rx USA LLC2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralBlenheim Pharmacal, Inc.2013-11-182016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralRebel Distributors Corp2007-10-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralSt Marys Medical Park Pharmacy2013-01-102016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralClinical Solutions Wholesale2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralbryant ranch prepack2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralProficient Rx LP2003-12-012016-04-05Us
Levothyroxine Sodiumtablet150 ug/1oralDispensing Solutions, Inc.2011-05-012016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralPreferred Pharmaceuticals, Inc.2003-12-012016-04-05Us
Levothyroxine Sodiumtablet125 ug/1oralPreferred Pharmaceuticals, Inc.2014-10-132016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralREMEDYREPACK INC.2013-02-142016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralREMEDYREPACK INC.2011-08-102016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralMedsource Pharmaceuticals2002-03-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralMed Health Pharma, LLC2011-01-012016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralREMEDYREPACK INC.2013-02-152016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralNorthwind Pharmaceuticals, LLC2015-02-042016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralUnit Dose Services2003-12-012016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralNorthwind Pharmaceuticals, LLC2014-10-212016-04-05Us
Levothyroxine Sodiumtablet150 ug/1oralPreferred Pharmaceuticals Inc.2016-03-022016-04-05Us
Levothyroxine Sodium for Injectionpowder for solution200 mcgintramuscular; intravenousFresenius Kabi Canada LtdNot applicableNot applicableCanada
Levothyroxine Sodium for Injectionpowder for solution500 mcgintramuscular; intravenousFresenius Kabi Canada Ltd2002-08-27Not applicableCanada
Levoxyltablet150 ug/1oralPhysicians Total Care, Inc.2001-08-222016-04-05Us
Levoxyltablet175 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet100 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet112 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet125 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet100 ug/1oralDispensing Solutions, Inc.2001-05-252016-04-05Us
Levoxyltablet75 ug/1oralPhysicians Total Care, Inc.2001-08-032016-04-05Us
Levoxyltablet25 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet100 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet50 ug/1oralDispensing Solutions, Inc.2001-05-252016-04-05Us
Levoxyltablet88 ug/1oralPhysicians Total Care, Inc.2000-05-102016-04-05Us
Levoxyltablet150 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet100 ug/1oralPhysicians Total Care, Inc.2001-08-032016-04-05Us
Levoxyltablet137 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet88 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet50 ug/1oralPhysicians Total Care, Inc.2002-11-152016-04-05Us
Levoxyltablet125 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet75 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet25 ug/1oralPhysicians Total Care, Inc.2003-06-202016-04-05Us
Levoxyltablet112 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet50 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet200 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet112 ug/1oralPhysicians Total Care, Inc.1996-08-292016-04-05Us
Levoxyltablet88 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet25 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet175 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet75 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet150 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
Levoxyltablet125 ug/1oralPhysicians Total Care, Inc.2001-12-112016-04-05Us
Levoxyltablet200 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet50 ug/1oralCardinal Health2001-05-252016-04-05Us
Levoxyltablet137 ug/1oralPfizer Laboratories Div Pfizer Inc2001-05-252016-04-05Us
PMS-levothyroxine Sodium Tab 100mcgtablet100 mcgoralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 125mcgtablet125 mcgoralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 150mcgtablet150 mcgoralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 200mcgtablet200 mcgoralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 25mcgtablet25 mcgoralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 300mcgtablet300 mcgoralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 50mcgtablet50 mcgoralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 75mcgtablet75 mcgoralPharmascience Inc1993-12-311998-08-07Canada
Synthroidtablet100 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet125 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet25 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet88 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet150 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet50 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet175 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet137 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet175 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet200 ug/1oralREMEDYREPACK INC.2012-09-272016-04-05Us
Synthroidtablet137 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet112 ug/1oralAvera Mc Kennan Hospital2015-03-092016-04-05Us
Synthroidtablet88 ug/1oralREMEDYREPACK INC.2013-03-292016-04-05Us
Synthroidtablet100 ug/1oralA S Medication Solutions Llc2002-07-242016-04-05Us
Synthroidtablet100 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet150 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet25 ug/1oralAvera Mc Kennan Hospital2015-03-092016-04-05Us
Synthroidtablet175 ug/1oralAvera Mc Kennan Hospital2015-04-032016-04-05Us
Synthroidtablet150 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet100 ug/1oralREMEDYREPACK INC.2012-09-272016-04-05Us
Synthroidtablet50 ug/1oralA S Medication Solutions Llc2002-07-242016-04-05Us
Synthroidtablet175 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet150 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet88 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet150 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet25 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet200 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet137 ug/1oralAvera Mc Kennan Hospital2015-03-102016-04-05Us
Synthroidtablet137 mcgoralBgp Pharma Ulc2003-11-01Not applicableCanada
Synthroidtablet125 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet137 ug/1oralREMEDYREPACK INC.2013-02-202016-04-05Us
Synthroidtablet75 ug/1oralA S Medication Solutions Llc2002-07-242016-04-05Us
Synthroidtablet88 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet75 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet75 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet75 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet300 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet150 ug/1oralAvera Mc Kennan Hospital2015-09-112016-04-05Us
Synthroidtablet100 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet25 ug/1oralREMEDYREPACK INC.2013-02-222016-04-05Us
Synthroidtablet100 ug/1oralState of Florida DOH Central Pharmacy2014-11-012016-04-05Us
Synthroidtablet112 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet50 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet75 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet88 ug/1oralAvera Mc Kennan Hospital2015-03-172016-04-05Us
Synthroidtablet88 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet75 ug/1oralREMEDYREPACK INC.2013-02-222016-04-05Us
Synthroidtablet75 ug/1oralState of Florida DOH Central Pharmacy2014-01-012016-04-05Us
Synthroidtablet25 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet50 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet100 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet88 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet112 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet75 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet125 ug/1oralREMEDYREPACK INC.2013-04-102016-04-05Us
Synthroidtablet125 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet25 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet50 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet50 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet125 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet300 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet50 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroidtablet150 ug/1oralREMEDYREPACK INC.2013-02-272016-04-05Us
Synthroidtablet125 ug/1oralPhysicians Total Care, Inc.2004-06-032016-04-05Us
Synthroidtablet300 ug/1oralCardinal Health2002-07-242016-04-05Us
Synthroidtablet175 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet88 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet112 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-07-242016-04-05Us
Synthroidtablet112 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet125 ug/1oralPd Rx Pharmaceuticals, Inc.2002-07-242016-04-05Us
Synthroidtablet50 ug/1oralREMEDYREPACK INC.2013-04-102016-04-05Us
Synthroidtablet150 ug/1oralA S Medication Solutions Llc2002-07-242016-04-05Us
Synthroidtablet200 ug/1oralCardinal Health2002-02-242016-04-05Us
Synthroidtablet75 ug/1oralDispensing Solutions, Inc.2002-07-242016-04-05Us
Synthroidtablet200 ug/1oralAphena Pharma Solutions Tennessee, Inc.2002-02-242016-04-05Us
Synthroidtablet25 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet100 mcgoralBgp Pharma Ulc1996-12-31Not applicableCanada
Synthroidtablet150 ug/1oralPd Rx Pharmaceuticals, Inc.2002-07-242016-04-05Us
Synthroidtablet200 ug/1oralAbb Vie Inc.2002-02-242016-04-23Us
Synthroidtablet25 ug/1oralAbb Vie Inc.2002-07-242016-04-23Us
Synthroid Liq Inj 500mcg/vial USPliquid500 mcgintravenousBoots Pharmaceuticals Ltd.1957-12-311996-09-09Canada
Synthroid Tab 100mcg USPtablet100 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 112mcg USPtablet112 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 125mcg USPtablet125 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 150mcg USPtablet150 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 175mcg USPtablet175 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 200mcg USPtablet200 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 25mcg USPtablet25 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 300mcg Tabtablet300 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 50mcg USPtablet50 mcgoralBoots Pharmaceuticals Ltd.1957-12-311996-09-09Canada
Synthroid Tab 75mcg USPtablet75 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 88mcg USPtablet88 mcgoralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Tirosintcapsule75 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule50 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule150 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule25 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule137 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule13 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule125 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule112 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule100 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Tirosintcapsule88 ug/1oralAkrimax Pharmaceuticals, LLC2010-04-012016-04-05Us
Unithroidtablet300 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet88 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet.3 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet.075 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet200 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet75 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet.2 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet.05 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet175 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet50 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet.175 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet.025 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet.15 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet150 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet25 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet.125 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet137 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet.112 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet125 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet.1 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Unithroidtablet112 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet.137 mg/1oralLannett Company, Inc.2007-10-012016-04-23Us
Unithroidtablet100 ug/1oralGemini Laboratories, LLC2014-07-032016-04-05Us
Unithroidtablet.088 mg/1oralLannett Company, Inc.2000-08-212016-04-23Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Levothyroxine Sodiumtablet.3 mg/1oralPhysicians Total Care, Inc.2000-12-052016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralPreferred Pharmaceuticals, Inc.2015-04-212016-04-05Us
Levothyroxine Sodiumtablet50 ug/1oralPhysicians Total Care, Inc.2005-03-092016-04-05Us
Levothyroxine Sodiumtablet125 ug/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralREMEDYREPACK INC.2013-08-132016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralREMEDYREPACK INC.2010-10-202016-04-05Us
Levothyroxine Sodiumtablet175 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet25 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet88 ug/1oralREMEDYREPACK INC.2013-07-052016-04-05Us
Levothyroxine Sodiumtablet.1 mg/1oralREMEDYREPACK INC.2011-05-232016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralREMEDYREPACK INC.2010-12-082016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralPd Rx Pharmaceuticals, Inc.2010-01-182016-04-05Us
Levothyroxine Sodiumtablet150 ug/1oralCardinal Health2010-10-292016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralPhysicians Total Care, Inc.1996-09-242016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralREMEDYREPACK INC.2010-08-042016-04-05Us
Levothyroxine Sodiumtablet150 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet.025 mg/1oralNorthwind Pharmaceuticals, LLC2014-10-082016-04-05Us
Levothyroxine Sodiumtablet.075 mg/1oralREMEDYREPACK INC.2011-06-272016-04-05Us
Levothyroxine Sodiumtablet50 ug/1oralPd Rx Pharmaceuticals, Inc.2010-01-182016-04-05Us
Levothyroxine Sodiumtablet125 ug/1oralCardinal Health2010-10-292016-04-05Us
Levothyroxine Sodiumtablet88 ug/1oralPhysicians Total Care, Inc.2008-10-242016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet175 ug/1oralPd Rx Pharmaceuticals, Inc.2010-01-182016-04-05Us
Levothyroxine Sodiumtablet125 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet150 ug/1oralMylan Institutional Inc.2007-02-262016-04-05Us
Levothyroxine Sodiumtablet.112 mg/1oralREMEDYREPACK INC.2011-06-222016-04-05Us
Levothyroxine Sodiumtablet150 ug/1oralPd Rx Pharmaceuticals, Inc.2012-08-082016-04-05Us
Levothyroxine Sodiumtablet112 ug/1oralPhysicians Total Care, Inc.2010-01-142016-04-05Us
Levothyroxine Sodiumtablet112 ug/1oralPd Rx Pharmaceuticals, Inc.2010-01-182016-04-05Us
Levothyroxine Sodiumtablet112 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet25 ug/1oralMylan Institutional Inc.2007-02-262016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralREMEDYREPACK INC.2011-03-292016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralPd Rx Pharmaceuticals, Inc.2010-01-182016-04-05Us
Levothyroxine Sodiumtablet.137 mg/1oralPhysicians Total Care, Inc.2005-11-212016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralPhysicians Total Care, Inc.1995-08-072016-04-05Us
Levothyroxine Sodiumtablet175 ug/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet88 ug/1oralPd Rx Pharmaceuticals, Inc.2010-01-182016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet125 ug/1oralMylan Institutional Inc.2007-02-052016-04-05Us
Levothyroxine Sodiumtablet.05 mg/1oralREMEDYREPACK INC.2011-05-032016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralCardinal Health2010-10-292016-04-05Us
Levothyroxine Sodiumtablet.175 mg/1oralPhysicians Total Care, Inc.2001-04-162016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralPhysicians Total Care, Inc.2007-09-172016-04-05Us
Levothyroxine Sodiumtablet50 ug/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet137 ug/1oralMylan Pharmaceuticals Inc.2006-12-152016-04-23Us
Levothyroxine Sodiumtablet88 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet100 ug/1oralMylan Institutional Inc.2007-02-052016-04-05Us
Levothyroxine Sodiumtablet.15 mg/1oralREMEDYREPACK INC.2011-03-082016-04-05Us
Levothyroxine Sodiumtablet100 ug/1oralCardinal Health2010-10-292016-04-05Us
Levothyroxine Sodiumtablet.125 mg/1oralPhysicians Total Care, Inc.1994-10-062016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralState of Florida DOH Central Pharmacy2013-01-012016-04-05Us
Levothyroxine Sodiumtablet150 ug/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet300 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet75 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet75 ug/1oralMylan Institutional Inc.2007-02-052016-04-05Us
Levothyroxine Sodiumtablet.2 mg/1oralREMEDYREPACK INC.2011-01-262016-04-05Us
Levothyroxine Sodiumtablet50 ug/1oralCardinal Health2010-10-292016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralPhysicians Total Care, Inc.2005-04-042016-04-05Us
Levothyroxine Sodiumtablet125 ug/1oralState of Florida DOH Central Pharmacy2014-01-012016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralState of Florida DOH Central Pharmacy2009-07-012016-04-05Us
Levothyroxine Sodiumtablet.025 mg/1oralREMEDYREPACK INC.2011-01-252016-04-05Us
Levothyroxine Sodiumtablet25 ug/1oralCardinal Health2010-10-292016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralPhysicians Total Care, Inc.1995-08-102016-04-05Us
Levothyroxine Sodiuminjection, powder, lyophilized, for solution200 ug/5mLintravenousPar Pharmaceutical Companies, Inc.2015-12-112016-04-05Us
Levothyroxine Sodiumtablet150 ug/1oralState of Florida DOH Central Pharmacy2013-01-012016-04-05Us
Levothyroxine Sodiumtablet75 ug/1oralREMEDYREPACK INC.2014-01-092016-04-05Us
Levothyroxine Sodiumtablet200 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet50 ug/1oralMylan Pharmaceuticals Inc.2002-11-012016-04-23Us
Levothyroxine Sodiumtablet50 ug/1oralMylan Institutional Inc.2007-02-052016-04-05Us
Over the Counter ProductsNot Available
International Brands
NameCompany
EutiroxMerck
LetroxBerlin-Chemie
LevaxinNycomed
LevothyroxMerck
NovothyroxNot Available
OroxineGlaxoSmithKline
ThyraxMerck
Brand mixtures
NameLabellerIngredients
Np Thyroid 30Acella Pharmaceuticals, LLC
Np Thyroid 60Acella Pharmaceuticals, LLC
Np Thyroid 90Acella Pharmaceuticals, LLC
Salts
Name/CASStructureProperties
Levothyroxine sodium
55-03-8
Thumb
  • InChI Key: YDTFRJLNMPSCFM-YDALLXLXSA-M
  • Monoisotopic Mass: 798.668626168
  • Average Mass: 798.8518
DBSALT000244
Categories
UNIIQ51BO43MG4
CAS number51-48-9
WeightAverage: 776.87
Monoisotopic: 776.686681525
Chemical FormulaC15H11I4NO4
InChI KeyInChIKey=XUIIKFGFIJCVMT-LBPRGKRZSA-N
InChI
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
IUPAC Name
(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
SMILES
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylethers
Direct ParentDiphenylethers
Alternative Parents
Substituents
  • Diphenylether
  • 3-phenylpropanoic-acid
  • Diaryl ether
  • L-alpha-amino acid
  • Amphetamine or derivatives
  • Alpha-amino acid or derivatives
  • Alpha-amino acid
  • 2-iodophenol
  • 2-halophenol
  • Aralkylamine
  • Phenol
  • Iodobenzene
  • Halobenzene
  • Amino fatty acid
  • Fatty acyl
  • Aryl iodide
  • Aryl halide
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organoiodide
  • Organohalogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationFor use alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor.
PharmacodynamicsLevothyroxine (T4) is a synthetically prepared levo isomer of thyroxine, the major hormone secreted from the thyroid gland. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine (T3) which exerts a broad spectrum of stimulatory effects on cell metabolism. Thyroid hormone increases the metabolic rate of cells of all tissues in the body. In the fetus and newborn, thyroid hormone is important for the growth and development of all tissues including bones and the brain. In adults, thyroid hormone helps to maintain brain function, food metabolism, and body temperature, among other effects. The symptoms of thyroid deficiency relieved by levothyroxine include slow speech, lack of energy, weight gain, hair loss, dry thick skin and unusual sensitivity to cold.
Mechanism of actionLevothyroxine acts like the endogenous thyroid hormone thyroxine (T4, a tetra-iodinated tyrosine derivative). In the liver and kidney, T4 is converted to T3, the active metabolite. In order to increase solubility, the thyroid hormones attach to thyroid hormone binding proteins, thyroxin-binding globulin, and thyroxin-binding prealbumin (transthyretin). Transport and binding to thyroid hormone receptors in the cytoplasm and nucleus then takes place. Thus by acting as a replacement for natural thyroxine, symptoms of thyroxine deficiency are relieved.
Related Articles
AbsorptionBioavailability varies from 48% to 80%. Human studies have confirmed the importance of an intact jejunum and ileum for levothyroxine absorption and have shown some absorption from the duodenum.
Volume of distributionNot Available
Protein binding> 99% to serum proteins, including thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (TBA)
Metabolism

Approximately 70% of secreted T4 is deiodinated to equal amounts of T3 and reverse triiodothyronine (rT3), which is calorigenically inactive. Elimination of T4 and T3 involves hepatic conjugation to glucuronic and sulfuric acids. The hormones undergo enterohepatic circulation as conjugates are hydrolyzed in the intestine and reabsorbed. Conjugated compounds that reach the colon are hydrolyzed and eliminated as free compounds in the feces. Other minor T4 metabolites have been identified.

Route of eliminationThyroid hormones are primarily eliminated by the kidneys.
Half lifeT4, 6 to 7 days. T3, 1 to 2 days.
ClearanceNot Available
ToxicityLD50=20 mg/kg (orally in rat). Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Thyroid hormone synthesisMetabolicSMP00716
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7212
Blood Brain Barrier-0.6886
Caco-2 permeable-0.653
P-glycoprotein substrateNon-substrate0.5321
P-glycoprotein inhibitor INon-inhibitor0.9175
P-glycoprotein inhibitor IINon-inhibitor0.9709
Renal organic cation transporterNon-inhibitor0.8891
CYP450 2C9 substrateNon-substrate0.8309
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.6847
CYP450 1A2 substrateNon-inhibitor0.5924
CYP450 2C9 inhibitorNon-inhibitor0.7037
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8459
Ames testNon AMES toxic0.7591
CarcinogenicityNon-carcinogens0.9148
BiodegradationNot ready biodegradable0.9693
Rat acute toxicity2.7082 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9697
hERG inhibition (predictor II)Non-inhibitor0.8508
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Institute biochimique sa (ibsa)
  • Institut biochimique sa ibsa
  • Vintage pharmaceuticals llc
  • Alara pharmaceutical corporation
  • Lloyd inc
  • Merck kgaa
  • Mylan pharmaceuticals inc
  • King pharmaceuticals inc
  • Abbott laboratories
  • Jerome stevens pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral.1 mg
Tabletoral.2 mg
Tabletoral.3 mg
Tabletoral.05 mg
Injection, powder, lyophilized, for solutionintravenous100 ug/5mL
Injection, powder, lyophilized, for solutionintravenous200 ug/5mL
Injection, powder, lyophilized, for solutionintravenous500 ug/5mL
Tabletoral.025 mg/1
Tabletoral.05 mg/1
Tabletoral.075 mg/1
Tabletoral.088 mg/1
Tabletoral.1 mg/1
Tabletoral.112 mg/1
Tabletoral.125 mg/1
Tabletoral.137 mg/1
Tabletoral.15 mg/1
Tabletoral.175 mg/1
Tabletoral.2 mg/1
Tabletoral.3 mg/1
Powder for solutionintramuscular; intravenous200 mcg
Powder for solutionintramuscular; intravenous500 mcg
Tablettopical
Tabletoral
Tabletoral100 mcg
Tabletoral100 ug/1
Tabletoral112 mcg
Tabletoral112 ug/1
Tabletoral125 mcg
Tabletoral125 ug/1
Tabletoral137 ug/1
Tabletoral137 mcg
Tabletoral150 ug/1
Tabletoral150 mcg
Tabletoral175 mcg
Tabletoral175 ug/1
Tabletoral200 mcg
Tabletoral200 ug/1
Tabletoral25 mcg
Tabletoral25 ug/1
Tabletoral300 ug/1
Tabletoral300 mcg
Tabletoral50 ug/1
Tabletoral50 mcg
Tabletoral75 ug/1
Tabletoral75 mcg
Tabletoral88 mcg
Tabletoral88 ug/1
Liquidintravenous500 mcg
Capsuleoral100 ug/1
Capsuleoral112 ug/1
Capsuleoral125 ug/1
Capsuleoral13 ug/1
Capsuleoral137 ug/1
Capsuleoral150 ug/1
Capsuleoral25 ug/1
Capsuleoral50 ug/1
Capsuleoral75 ug/1
Capsuleoral88 ug/1
Prices
Unit descriptionCostUnit
Levothyroxine sodium powder159.12USD g
Levothyroxine 200 mcg vial24.0USD vial
Levothyroxine 500 mcg vial24.0USD vial
Levoxyl 300 mcg tablet2.34USD tablet
Synthroid 300 mcg tablet1.29USD tablet
Synthroid 175 mcg tablet1.07USD tablet
Synthroid 200 mcg tablet0.99USD tablet
Synthroid 137 mcg tablet0.87USD tablet
Synthroid 112 mcg tablet0.84USD tablet
Synthroid 125 mcg tablet0.84USD tablet
Synthroid 150 mcg tablet0.83USD tablet
Levothyroxine Sodium 300 mcg tablet0.77USD tablet
Synthroid 100 mcg tablet0.73USD tablet
Synthroid 75 mcg tablet0.72USD tablet
Synthroid 88 mcg tablet0.71USD tablet
Levoxyl 200 mcg tablet0.7USD tablet
Levoxyl 175 mcg tablet0.69USD tablet
Unithroid 300 mcg tablet0.69USD tablet
Synthroid 50 mcg tablet0.65USD tablet
Levoxyl 137 mcg tablet0.62USD tablet
Unithroid 200 mcg tablet0.62USD tablet
Levoxyl 112 mcg tablet0.61USD tablet
Synthroid 25 mcg tablet0.61USD tablet
Unithroid 175 mcg tablet0.61USD tablet
Levoxyl 150 mcg tablet0.59USD tablet
Levoxyl 125 mcg tablet0.58USD tablet
Levothyroxine Sodium 175 mcg tablet0.57USD tablet
Levothyroxine Sodium 200 mcg tablet0.57USD tablet
Levothyroxine 175 mcg tablet0.55USD tablet
Unithroid 150 mcg tablet0.55USD tablet
Levoxyl 88 mcg tablet0.54USD tablet
Unithroid 112 mcg tablet0.53USD tablet
Unithroid 125 mcg tablet0.53USD tablet
Levoxyl 75 mcg tablet0.52USD tablet
Levothroid 300 mcg tablet0.51USD tablet
Levoxyl 100 mcg tablet0.51USD tablet
Levothyroxine Sodium 100 mcg tablet0.5USD tablet
Levothyroxine Sodium 150 mcg tablet0.5USD tablet
Levothyroxine Sodium 88 mcg tablet0.5USD tablet
Levoxyl 50 mcg tablet0.49USD tablet
Unithroid 88 mcg tablet0.49USD tablet
Unithroid 100 mcg tablet0.47USD tablet
Unithroid 75 mcg tablet0.47USD tablet
Levothyroxine Sodium 125 mcg tablet0.47USD tablet
Levothyroxine Sodium 137 mcg tablet0.47USD tablet
Levothyroxine Sodium 50 mcg tablet0.47USD tablet
Levothyroxine Sodium 75 mcg tablet0.47USD tablet
Levothyroxine Sodium 112 mcg tablet0.46USD tablet
Levothyroxine 137 mcg tablet0.45USD tablet
Levoxyl 25 mcg tablet0.45USD tablet
Levothyroxine 112 mcg tablet0.44USD tablet
Levothyroxine Sodium 25 mcg tablet0.43USD tablet
Unithroid 50 mcg tablet0.43USD tablet
Unithroid 25 mcg tablet0.42USD tablet
Unithroid direct 100 mcg tablet0.42USD tablet
Unithroid direct 112 mcg tablet0.42USD tablet
Unithroid direct 125 mcg tablet0.42USD tablet
Unithroid direct 150 mcg tablet0.42USD tablet
Unithroid direct 175 mcg tablet0.42USD tablet
Unithroid direct 200 mcg tablet0.42USD tablet
Unithroid direct 25 mcg tablet0.42USD tablet
Unithroid direct 300 mcg tablet0.42USD tablet
Unithroid direct 50 mcg tablet0.42USD tablet
Unithroid direct 75 mcg tablet0.42USD tablet
Unithroid direct 88 mcg tablet0.42USD tablet
Levothroid 200 mcg tablet0.4USD tablet
Levothroid 175 mcg tablet0.38USD tablet
Levothyroxine 88 mcg tablet0.38USD tablet
Levothroid 125 mcg tablet0.36USD tablet
Levothroid 150 mcg tablet0.36USD tablet
Levothroid 100 mcg tablet0.35USD tablet
Levothroid 137 mcg tablet0.35USD tablet
Levothroid 112 mcg tablet0.34USD tablet
Levothroid 75 mcg tablet0.33USD tablet
Levothroid 88 mcg tablet0.33USD tablet
Levothyroxine 300 mcg tablet0.32USD tablet
Levothroid 25 mcg tablet0.31USD tablet
Unithroid 137 mcg tablet0.31USD tablet
Levothroid 50 mcg tablet0.3USD tablet
Levothyroxine 200 mcg tablet0.29USD tablet
Levothyroxine 150 mcg tablet0.24USD tablet
Levothyroxine 125 mcg tablet0.22USD tablet
Levothyroxine 100 mcg tablet0.2USD tablet
Levothyroxine 75 mcg tablet0.2USD tablet
Levothyroxine 50 mcg tablet0.18USD tablet
Synthroid 0.137 mg Tablet0.18USD tablet
Levothyroxine 25 mcg tablet0.17USD tablet
Synthroid 0.3 mg Tablet0.12USD tablet
Synthroid 0.175 mg Tablet0.11USD tablet
Synthroid 0.075 mg Tablet0.1USD tablet
Synthroid 0.088 mg Tablet0.1USD tablet
Synthroid 0.112 mg Tablet0.1USD tablet
Synthroid 0.125 mg Tablet0.1USD tablet
Synthroid 0.025 mg Tablet0.09USD tablet
Synthroid 0.2 mg Tablet0.09USD tablet
Synthroid 0.1 mg Tablet0.08USD tablet
Synthroid 0.15 mg Tablet0.08USD tablet
Eltroxin 0.3 mg Tablet0.07USD tablet
Synthroid 0.05 mg Tablet0.06USD tablet
Eltroxin 0.2 mg Tablet0.05USD tablet
Eltroxin 0.1 mg Tablet0.04USD tablet
Eltroxin 0.15 mg Tablet0.04USD tablet
Eltroxin 0.05 mg Tablet0.03USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6399101 No2000-03-302020-03-30Us
US6555581 No2002-02-152022-02-15Us
US7067148 No2002-02-152022-02-15Us
US7101569 No2003-10-022023-10-02Us
US7723390 No2004-03-142024-03-14Us
US9006289 No2012-10-032032-10-03Us
US9168238 No2012-08-292032-08-29Us
US9168239 No2012-08-292032-08-29Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point235.5 °CPhysProp
water solubility0.105 mg/mLNot Available
logP4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00898 mg/mLALOGPS
logP1.15ALOGPS
logP3.73ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)0.27ChemAxon
pKa (Strongest Basic)9.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.78 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity126.79 m3·mol-1ChemAxon
Polarizability49.4 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-3mz7ongf60-c9b7aec3184ebb20a2daView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-8npohhzkf0-35bb942c7bcbcfe41af7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-deumiztla0-9dee3cb0c153e6c6df9eView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Jivn-Ren Chen, Dimitri C. Papadimitriou, “Stable dosage of levothyroxine sodium and process of production.” U.S. Patent US5225204, issued November, 1991.

US5225204
General References
  1. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. [PubMed:11901210 ]
External Links
ATC CodesH03AA01
AHFS Codes
  • 68:36.04
PDB EntriesNot Available
FDA labelDownload (54.3 KB)
MSDSDownload (51.7 KB)
Interactions
Drug Interactions
Drug
Aluminum hydroxideThe serum concentration of Levothyroxine can be decreased when it is combined with Aluminum hydroxide.
AmitriptylineLevothyroxine may increase the arrhythmogenic activities of Amitriptyline.
CarbamazepineThe serum concentration of Levothyroxine can be decreased when it is combined with Carbamazepine.
ChlorotrianiseneThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Chlorotrianisene.
CiprofloxacinThe serum concentration of Levothyroxine can be decreased when it is combined with Ciprofloxacin.
ColesevelamThe serum concentration of Levothyroxine can be decreased when it is combined with Colesevelam.
DicoumarolLevothyroxine may increase the anticoagulant activities of Dicoumarol.
Ferric CitrateThe serum concentration of Levothyroxine can be decreased when it is combined with Ferric Citrate.
FosphenytoinThe serum concentration of Levothyroxine can be decreased when it is combined with Fosphenytoin.
Iron DextranThe serum concentration of Levothyroxine can be decreased when it is combined with Iron Dextran.
LanthanumThe serum concentration of Levothyroxine can be decreased when it is combined with Lanthanum.
Magnesium chlorideThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium chloride.
Magnesium citrateThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium citrate.
Magnesium hydroxideThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium hydroxide.
Magnesium oxideThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium oxide.
Magnesium salicylateThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium salicylate.
Magnesium SulfateThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium Sulfate.
OrlistatThe serum concentration of Levothyroxine can be decreased when it is combined with Orlistat.
ParoxetineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Paroxetine.
PhenytoinThe serum concentration of Levothyroxine can be decreased when it is combined with Phenytoin.
PiracetamThe risk or severity of adverse effects can be increased when Piracetam is combined with Levothyroxine.
PolaprezincThe serum concentration of Levothyroxine can be decreased when it is combined with Polaprezinc.
Polystyrene sulfonateThe serum concentration of Levothyroxine can be decreased when it is combined with Polystyrene sulfonate.
RaloxifeneRaloxifene can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
RifampicinThe serum concentration of Levothyroxine can be decreased when it is combined with Rifampicin.
SevelamerThe serum concentration of Levothyroxine can be decreased when it is combined with Sevelamer.
Sodium Iodide I-131The therapeutic efficacy of Sodium Iodide I-131 can be decreased when used in combination with Levothyroxine.
SucralfateThe serum concentration of Levothyroxine can be decreased when it is combined with Sucralfate.
Sucroferric OxyhydroxideThe serum concentration of Levothyroxine can be decreased when it is combined with Sucroferric Oxyhydroxide.
TheophyllineThe metabolism of Theophylline can be increased when combined with Levothyroxine.
Food Interactions
  • Absorption increased in fasting state and decreased in malabsorption states.
  • Consistent administration in relation to meals is recommended.
  • No iron or calium carbonate within 4 hours of taking this medication.
  • Oral administration with infant soybean formula, soybean flour, cotton seed meal, walnuts, foods containing large amounts of fiber, ferrous sulfate, and antacids may decrease drug absorption.
  • Take 30-60 minutes before breakfast.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Gene Name:
THRA
Uniprot ID:
P10827
Molecular Weight:
54815.055 Da
References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  3. Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59. [PubMed:17315033 ]
  4. Nakajima Y, Yamada M, Horiguchi K, Satoh T, Hashimoto K, Tokuhiro E, Onigata K, Mori M: Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor. Thyroid. 2010 Aug;20(8):917-26. doi: 10.1089/thy.2009.0389. [PubMed:20615127 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Gene Name:
THRB
Uniprot ID:
P10828
Molecular Weight:
52787.16 Da
References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  2. Marazuela M, Nattero L, Moure D, Garcia-Polo I, Figueroa-Vega N, Guijarro C: Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23. doi: 10.1089/thy.2007.0375. [PubMed:18816177 ]
  3. Sivakumar T, Chaidarun S: Resistance to thyroid hormone in a patient with coexisting Graves' disease. Thyroid. 2010 Feb;20(2):213-6. doi: 10.1089/thy.2009.0175. [PubMed:20151830 ]
  4. Grasberger H, Ringkananont U, Croxson M, Refetoff S: Resistance to thyroid hormone in a patient with thyroid dysgenesis. Thyroid. 2005 Jul;15(7):730-3. [PubMed:16053391 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Identical protein binding
Specific Function:
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Gene Name:
TTR
Uniprot ID:
P02766
Molecular Weight:
15886.88 Da
References
  1. Eneqvist T, Lundberg E, Karlsson A, Huang S, Santos CR, Power DM, Sauer-Eriksson AE: High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine. J Biol Chem. 2004 Jun 18;279(25):26411-6. Epub 2004 Apr 13. [PubMed:15082720 ]
  2. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. [PubMed:12553433 ]
Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Major thyroid hormone transport protein in serum.
Gene Name:
SERPINA7
Uniprot ID:
P05543
Molecular Weight:
46324.12 Da
References
  1. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. [PubMed:12553433 ]
Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. [PubMed:12553433 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Thyroid hormone transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).
Gene Name:
SLCO1C1
Uniprot ID:
Q9NYB5
Molecular Weight:
78695.625 Da
References
  1. Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. doi: 10.1210/en.2008-0188. Epub 2008 Oct 9. [PubMed:18845642 ]
  2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
  3. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. [PubMed:12351693 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.
Gene Name:
SLC16A2
Uniprot ID:
P36021
Molecular Weight:
59510.86 Da
References
  1. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ: Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem. 2003 Oct 10;278(41):40128-35. Epub 2003 Jul 18. [PubMed:12871948 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Siegmund W, Altmannsberger S, Paneitz A, Hecker U, Zschiesche M, Franke G, Meng W, Warzok R, Schroeder E, Sperker B, Terhaag B, Cascorbi I, Kroemer HK: Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition. Clin Pharmacol Ther. 2002 Sep;72(3):256-64. [PubMed:12235446 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [PubMed:11159893 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [PubMed:11159893 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [PubMed:11159893 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Thyroid hormone transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.
Gene Name:
SLCO4A1
Uniprot ID:
Q96BD0
Molecular Weight:
77192.505 Da
References
  1. Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. [PubMed:11316767 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first...
Gene Name:
SLCO4C1
Uniprot ID:
Q6ZQN7
Molecular Weight:
78947.525 Da
References
  1. Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. [PubMed:14993604 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptide antigen binding
Specific Function:
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the ...
Gene Name:
SLC7A5
Uniprot ID:
Q01650
Molecular Weight:
55009.62 Da
References
  1. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. [PubMed:11901210 ]
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Drug created on June 13, 2005 07:24 / Updated on April 30, 2016 02:29