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Identification
NameLevothyroxine
Accession NumberDB00451  (APRD00235, EXPT02993)
TypeSmall Molecule
GroupsApproved
Description

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
3,3',5,5'-Tetraiodo-L-thyronineNot AvailableNot Available
3,5,3',5'-TETRAIODO-L-thyronineNot AvailableNot Available
4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanineNot AvailableNot Available
L-T4Not AvailableNot Available
L-ThyroxineNot AvailableNot Available
LevothyroxinNot AvailableNot Available
LevothyroxineNot AvailableNot Available
LT4Not AvailableNot Available
O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosineNot AvailableNot Available
O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosineNot AvailableNot Available
T4Not AvailableNot Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Synthroidtablet137 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet25 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet50 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet75 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet88 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet100 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet125 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet150 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet175 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet200 ugoralAbb Vie Inc.2002-02-24Not AvailableUs
Synthroidtablet300 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Synthroidtablet112 ugoralAbb Vie Inc.2002-07-24Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.175 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.3 mgoralLannett Company, Inc.2003-12-01Not AvailableUs
Unithroidtablet.025 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.05 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.075 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.088 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.1 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.112 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.125 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.15 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.175 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.2 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Unithroidtablet.3 mgoralLannett Company, Inc.2000-08-21Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralLannett Company, Inc.2007-10-01Not AvailableUs
Unithroidtablet.137 mgoralLannett Company, Inc.2007-10-01Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet88 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet112 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet175 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet200 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet300 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet137 ugoralSandoz Inc.2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralSTAT Rx USA LLC2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralSTAT Rx USA LLC2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralSTAT Rx USA LLC2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralRebel Distributors Corp.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralRebel Distributors Corp.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralRebel Distributors Corp.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralRebel Distributors Corp2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralRebel Distributors Corp.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralRebel Distributors Corp2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralRebel Distributors Corp.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralRebel Distributors Corp2007-10-01Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralRebel Distributors Corp.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.175 mgoralRebel Distributors Corp2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralRebel Distributors Corp.2003-12-01Not AvailableUs
Tirosintcapsule13 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule25 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule50 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule75 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule88 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule100 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule112 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule125 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule137 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Tirosintcapsule150 ugoralAkrimax Pharmaceuticals, LLC2010-04-01Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralREMEDYREPACK INC.2013-04-10Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralREMEDYREPACK INC.2013-02-16Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralREMEDYREPACK INC.2013-08-27Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralREMEDYREPACK INC.2013-02-14Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralREMEDYREPACK INC.2011-09-27Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralAidarex Pharmaceuticals LLC2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralLake Erie Medical DBA Quality Care Products LLC2007-10-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralLake Erie Medical DBA Quality Care Products LLC2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet112 ugoralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet88 ugoralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not AvailableUs
Synthroidtablet150 ugoralPd Rx Pharmaceuticals, Inc.2002-07-24Not AvailableUs
Synthroidtablet125 ugoralPd Rx Pharmaceuticals, Inc.2002-07-24Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Synthroidtablet137 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralREMEDYREPACK INC.2011-07-14Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralREMEDYREPACK INC.2011-07-13Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralREMEDYREPACK INC.2011-07-14Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralREMEDYREPACK INC.2011-07-15Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralREMEDYREPACK INC.2011-07-22Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralREMEDYREPACK INC.2011-07-28Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralREMEDYREPACK INC.2011-08-10Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralREMEDYREPACK INC.2011-08-10Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralREMEDYREPACK INC.2011-10-21Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralREMEDYREPACK INC.2011-12-07Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralREMEDYREPACK INC.2011-12-08Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralREMEDYREPACK INC.2011-10-31Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralREMEDYREPACK INC.2011-11-01Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralREMEDYREPACK INC.2011-12-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralREMEDYREPACK INC.2011-12-28Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralREMEDYREPACK INC.2013-02-15Not AvailableUs
Levothyroxine Sodiumtablet175 ugoralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralUnit Dose Services2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralUnit Dose Services2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralUnit Dose Services2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralUnit Dose Services2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralUnit Dose Services2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralUnit Dose Services2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralUnit Dose Services2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralUnit Dose Services2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralUnit Dose Services2007-10-01Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.3 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxine Sodiumtablet.175 mgoralMed Health Pharma, LLC2011-01-01Not AvailableUs
Levothyroxinetablet25 ugoralNorthwind Pharmaceuticals, LLC2014-07-10Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralNorthwind Pharmaceuticals, LLC2014-07-31Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralNorthwind Pharmaceuticals, LLC2014-10-21Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralNorthwind Pharmaceuticals2014-12-17Not AvailableUs
Levothyroxinetablet125 ugoralNorthwind Pharmaceuticals, LLC2014-09-14Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralNorthwind Pharmaceuticals, LLC2014-11-03Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralNorthwind Pharmaceuticals, LLC2014-11-25Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralNorthwind Pharmaceuticals2014-12-17Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralNorthwind Pharmaceuticals2014-12-23Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralNorthwind Pharmaceuticals, LLC2014-09-03Not AvailableUs
Synthroidtablet125 ugoralREMEDYREPACK INC.2013-04-10Not AvailableUs
Synthroidtablet75 ugoralREMEDYREPACK INC.2013-02-22Not AvailableUs
Synthroidtablet25 ugoralREMEDYREPACK INC.2013-02-22Not AvailableUs
Synthroidtablet137 ugoralREMEDYREPACK INC.2013-02-20Not AvailableUs
Synthroidtablet100 ugoralREMEDYREPACK INC.2012-09-27Not AvailableUs
Synthroidtablet200 ugoralREMEDYREPACK INC.2012-09-27Not AvailableUs
Synthroidtablet88 ugoralREMEDYREPACK INC.2013-03-29Not AvailableUs
Synthroidtablet50 ugoralREMEDYREPACK INC.2013-04-10Not AvailableUs
Synthroidtablet150 ugoralREMEDYREPACK INC.2013-02-27Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralREMEDYREPACK INC.2013-02-19Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralREMEDYREPACK INC.2013-05-07Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralREMEDYREPACK INC.2013-05-06Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralREMEDYREPACK INC.2013-11-18Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralREMEDYREPACK INC.2013-08-27Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralREMEDYREPACK INC.2013-08-13Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralREMEDYREPACK INC.2013-07-08Not AvailableUs
Levothyroxine Sodiumtablet112 ugoralREMEDYREPACK INC.2013-12-31Not AvailableUs
Levothyroxine Sodiumtablet112 ugoralREMEDYREPACK INC.2013-07-08Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralREMEDYREPACK INC.2013-10-29Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralREMEDYREPACK INC.2013-08-13Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralREMEDYREPACK INC.2013-08-13Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralREMEDYREPACK INC.2013-08-13Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralREMEDYREPACK INC.2013-10-09Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralREMEDYREPACK INC.2013-09-24Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralREMEDYREPACK INC.2013-11-01Not AvailableUs
Levothyroxine Sodiumtablet.175 mgoralREMEDYREPACK INC.2014-02-03Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralH.J. Harkins Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralH.J. Harkins Company, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs
Synthroidtablet75 ugoralState of Florida DOH Central Pharmacy2014-01-01Not AvailableUs
Synthroidtablet100 ugoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs
Synthroidtablet75 ugoralA S Medication Solutions Llc2002-07-24Not AvailableUs
Synthroidtablet50 ugoralA S Medication Solutions Llc2002-07-24Not AvailableUs
Synthroidtablet100 ugoralA S Medication Solutions Llc2002-07-24Not AvailableUs
Synthroidtablet150 ugoralA S Medication Solutions Llc2002-07-24Not AvailableUs
Synthroidtablet125 ugoralPhysicians Total Care, Inc.2004-06-03Not AvailableUs
Levoxyltablet112 ugoralPhysicians Total Care, Inc.1996-08-29Not AvailableUs
Levoxyltablet25 ugoralPhysicians Total Care, Inc.2003-06-20Not AvailableUs
Levoxyltablet50 ugoralPhysicians Total Care, Inc.2002-11-15Not AvailableUs
Levoxyltablet100 ugoralPhysicians Total Care, Inc.2001-08-03Not AvailableUs
Levoxyltablet88 ugoralPhysicians Total Care, Inc.2000-05-10Not AvailableUs
Levoxyltablet75 ugoralPhysicians Total Care, Inc.2001-08-03Not AvailableUs
Levoxyltablet150 ugoralPhysicians Total Care, Inc.2001-08-22Not AvailableUs
Levoxyltablet125 ugoralPhysicians Total Care, Inc.2001-12-11Not AvailableUs
Levothroidtablet150 ugoralPhysicians Total Care, Inc.2002-03-08Not AvailableUs
Levothroidtablet175 ugoralPhysicians Total Care, Inc.2003-09-12Not AvailableUs
Levothroidtablet200 ugoralPhysicians Total Care, Inc.2005-05-20Not AvailableUs
Synthroidtablet50 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet75 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet150 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet100 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet200 ugoralCardinal Health2002-02-24Not AvailableUs
Synthroidtablet300 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet125 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet25 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet112 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet88 ugoralCardinal Health2002-07-24Not AvailableUs
Synthroidtablet175 ugoralCardinal Health2002-07-24Not AvailableUs
Levoxyltablet25 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet100 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet50 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet75 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet88 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet112 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet125 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet137 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet150 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet175 ugoralCardinal Health2001-05-25Not AvailableUs
Levoxyltablet200 ugoralCardinal Health2001-05-25Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralPd Rx Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet200 ugoralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralClinical Solutions Wholesale2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralSt Marys Medical Park Pharmacy2014-04-09Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralSt Marys Medical Park Pharmacy2013-07-11Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralSt Marys Medical Park Pharmacy2013-05-16Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralSt Marys Medical Park Pharmacy2013-05-16Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralSt Marys Medical Park Pharmacy2013-07-11Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralSt Marys Medical Park Pharmacy2013-07-11Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralSt Marys Medical Park Pharmacy2013-05-16Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralSt Marys Medical Park Pharmacy2013-01-10Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralSt Marys Medical Park Pharmacy2013-05-16Not AvailableUs
Levoxyltablet25 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet50 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet75 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet88 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet100 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet112 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet125 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet137 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet150 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet175 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Levoxyltablet200 ugoralPfizer Laboratories Div Pfizer Inc2001-05-25Not AvailableUs
Unithroidtablet25 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet50 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet75 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet88 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet100 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet112 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet125 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet137 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet150 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet175 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet200 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Unithroidtablet300 ugoralGemini Laboratories, LLC2014-07-03Not AvailableUs
Levothyroxine Sodiuminjection, powder, lyophilized, for solution200 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-24Not AvailableUs
Levothyroxine Sodiuminjection, powder, lyophilized, for solution200 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-24Not AvailableUs
Levothyroxine Sodiuminjection, powder, lyophilized, for solution500 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-24Not AvailableUs
Levothyroxine Sodiuminjection, powder, lyophilized, for solution500 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-24Not AvailableUs
Levothyroxine Sodiuminjection, powder, lyophilized, for solution100 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-24Not AvailableUs
Levothyroxine Sodiuminjection, powder, lyophilized, for solution100 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-24Not AvailableUs
Levothyroxine Sodiuminjection, powder, lyophilized, for solution100 ug/5mLintravenousFresenius Kabi USA, LLC2011-06-24Not AvailableUs
Levothyroxine Sodiumtablet88 ugoralbryant ranch prepack2011-05-01Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralbryant ranch prepack2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralbryant ranch prepack2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralbryant ranch prepack2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralbryant ranch prepack2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralbryant ranch prepack2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralbryant ranch prepack2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralbryant ranch prepack2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.175 mgoralbryant ranch prepack2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralbryant ranch prepack2007-10-01Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralDispensing Solutions, Inc.2003-12-01Not AvailableUs
Synthroidtablet25 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Synthroidtablet75 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Synthroidtablet88 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralDispensing Solutions, Inc.2007-10-01Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralDispensing Solutions, Inc.2003-12-01Not AvailableUs
Synthroidtablet50 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Synthroidtablet100 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Levothyroxine Sodiumtablet.175 mgoralDispensing Solutions, Inc.2003-12-01Not AvailableUs
Synthroidtablet150 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Levoxyltablet50 ugoralDispensing Solutions, Inc.2001-05-25Not AvailableUs
Levoxyltablet100 ugoralDispensing Solutions, Inc.2001-05-25Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralDispensing Solutions, Inc.2011-05-01Not AvailableUs
Synthroidtablet175 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet25 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet50 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet75 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet88 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet100 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet125 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet150 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet200 ugoralAphena Pharma Solutions Tennessee, Inc.2002-02-24Not AvailableUs
Synthroidtablet112 ugoralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not AvailableUs
Synthroidtablet50 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Synthroidtablet88 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Synthroidtablet75 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Synthroidtablet25 ugoralDispensing Solutions, Inc.2002-07-24Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralPreferred Pharmaceuticals, Inc.2003-12-01Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet.088 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet.175 mgoralPreferred Pharmaceuticals, Inc.2009-09-09Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralPreferred Pharmaceuticals, Inc.2014-10-13Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralPreferred Pharmaceuticals, Inc.2014-10-13Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralPreferred Pharmaceuticals, Inc.2014-10-13Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralPreferred Pharmaceuticals, Inc.2014-10-13Not AvailableUs
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Levothyroxine Sodiumtablet25 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet88 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet112 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet175 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet200 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet300 ugoralMylan Pharmaceuticals Inc.2002-11-01Not AvailableUs
Levothyroxine Sodiumtablet137 ugoralMylan Pharmaceuticals Inc.2006-12-15Not AvailableUs
Levothyroxine Sodiumtablet88 ugoralPd Rx Pharmaceuticals, Inc.2010-01-18Not AvailableUs
Levothyroxine Sodiumtablet112 ugoralPd Rx Pharmaceuticals, Inc.2010-01-18Not AvailableUs
Levothyroxine Sodiumtablet175 ugoralPd Rx Pharmaceuticals, Inc.2010-01-18Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralREMEDYREPACK INC.2010-08-04Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralREMEDYREPACK INC.2010-10-20Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralREMEDYREPACK INC.2010-12-08Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralREMEDYREPACK INC.2011-01-25Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralREMEDYREPACK INC.2011-01-26Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralREMEDYREPACK INC.2011-03-08Not AvailableUs
Levothyroxine Sodiumtablet.05 mgoralREMEDYREPACK INC.2011-05-03Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralREMEDYREPACK INC.2011-03-29Not AvailableUs
Levothyroxine Sodiumtablet.112 mgoralREMEDYREPACK INC.2011-06-22Not AvailableUs
Levothyroxine Sodiumtablet.075 mgoralREMEDYREPACK INC.2011-06-27Not AvailableUs
Levothyroxine Sodiumtablet.1 mgoralREMEDYREPACK INC.2011-05-23Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralMylan Institutional Inc.2007-02-05Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralMylan Institutional Inc.2007-02-05Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralMylan Institutional Inc.2007-02-05Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralMylan Institutional Inc.2007-02-05Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralMylan Institutional Inc.2007-02-26Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralMylan Institutional Inc.2007-02-26Not AvailableUs
Levothyroxine Sodiumtablet.025 mgoralNorthwind Pharmaceuticals, LLC2014-10-08Not AvailableUs
Levothyroxine Sodiumtablet88 ugoralREMEDYREPACK INC.2013-07-05Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralREMEDYREPACK INC.2013-08-13Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralREMEDYREPACK INC.2014-01-09Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet175 ugoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralState of Florida DOH Central Pharmacy2014-01-01Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralPhysicians Total Care, Inc.2007-09-17Not AvailableUs
Levothyroxine Sodiumtablet.2 mgoralPhysicians Total Care, Inc.1995-08-07Not AvailableUs
Levothyroxine Sodiumtablet88 ugoralPhysicians Total Care, Inc.2008-10-24Not AvailableUs
Levothyroxine Sodiumtablet.15 mgoralPhysicians Total Care, Inc.1996-09-24Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralPhysicians Total Care, Inc.2005-03-09Not AvailableUs
Levothyroxine Sodiumtablet.3 mgoralPhysicians Total Care, Inc.2000-12-05Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralPhysicians Total Care, Inc.1995-08-10Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralPhysicians Total Care, Inc.2005-04-04Not AvailableUs
Levothyroxine Sodiumtablet.125 mgoralPhysicians Total Care, Inc.1994-10-06Not AvailableUs
Levothyroxine Sodiumtablet.175 mgoralPhysicians Total Care, Inc.2001-04-16Not AvailableUs
Levothyroxine Sodiumtablet.137 mgoralPhysicians Total Care, Inc.2005-11-21Not AvailableUs
Levothyroxine Sodiumtablet112 ugoralPhysicians Total Care, Inc.2010-01-14Not AvailableUs
Levothyroxine Sodiumtablet125 ugoralCardinal Health2010-10-29Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralCardinal Health2010-10-29Not AvailableUs
Levothyroxine Sodiumtablet25 ugoralCardinal Health2010-10-29Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralCardinal Health2010-10-29Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralCardinal Health2010-10-29Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralCardinal Health2010-10-29Not AvailableUs
Levothyroxine Sodiumtablet75 ugoralPd Rx Pharmaceuticals, Inc.2010-01-18Not AvailableUs
Levothyroxine Sodiumtablet150 ugoralPd Rx Pharmaceuticals, Inc.2012-08-08Not AvailableUs
Levothyroxine Sodiumtablet50 ugoralPd Rx Pharmaceuticals, Inc.2010-01-18Not AvailableUs
Levothyroxine Sodiumtablet100 ugoralPd Rx Pharmaceuticals, Inc.2010-01-18Not AvailableUs
Over the Counter ProductsNot Available
International Brands
NameCompany
EltroxinGlaxoSmithKline
EuthyroxMerck
EutiroxMerck
LetroxBerlin-Chemie
LevaxinNycomed
LevothyroxMerck
NovothyroxNot Available
OroxineGlaxoSmithKline
ThyraxMerck
Brand mixtures
Brand NameIngredients
LiotrixLevothyroxine + Liothyronine
ThyrolarLevothyroxine + Liothyronine
Salts
Name/CASStructureProperties
Levothyroxine Sodium
55-03-8
Thumb
  • InChI Key: YDTFRJLNMPSCFM-YDALLXLXSA-M
  • Monoisotopic Mass: 798.668626168
  • Average Mass: 798.8518
DBSALT000244
CategoriesNot Available
CAS number51-48-9
WeightAverage: 776.87
Monoisotopic: 776.686681525
Chemical FormulaC15H11I4NO4
InChI KeyXUIIKFGFIJCVMT-LBPRGKRZSA-N
InChI
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
IUPAC Name
(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
SMILES
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassPhenylpropanoids and Polyketides
ClassPhenylpropanoic Acids
SubclassNot Available
Direct parentPhenylpropanoic Acids
Alternative parentsDiarylethers; Amphetamines and Derivatives; Alpha Amino Acids and Derivatives; o-Iodophenols; Phenol Ethers; Amino Fatty Acids; Iodobenzenes; Aryl Iodides; Polyols; Enolates; Carboxylic Acids; Enols; Polyamines; Monoalkylamines; Organoiodides
Substituents2-iodophenol; 2-halophenol; phenol ether; iodobenzene; phenol derivative; benzene; aryl iodide; aryl halide; polyol; enolate; polyamine; carboxylic acid derivative; carboxylic acid; enol; ether; amine; organohalogen; organoiodide; primary aliphatic amine; organonitrogen compound; primary amine
Classification descriptionThis compound belongs to the phenylpropanoic acids. These are compounds whose structure contain a benzene ring conjugated to a propanoic acid.
Pharmacology
IndicationFor use alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor.
PharmacodynamicsLevothyroxine (T4) is a synthetically prepared levo isomer of thyroxine, the major hormone secreted from the thyroid gland. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine (T3) which exerts a broad spectrum of stimulatory effects on cell metabolism. Thyroid hormone increases the metabolic rate of cells of all tissues in the body. In the fetus and newborn, thyroid hormone is important for the growth and development of all tissues including bones and the brain. In adults, thyroid hormone helps to maintain brain function, food metabolism, and body temperature, among other effects. The symptoms of thyroid deficiency relieved by levothyroxine include slow speech, lack of energy, weight gain, hair loss, dry thick skin and unusual sensitivity to cold.
Mechanism of actionLevothyroxine acts like the endogenous thyroid hormone thyroxine (T4, a tetra-iodinated tyrosine derivative). In the liver and kidney, T4 is converted to T3, the active metabolite. In order to increase solubility, the thyroid hormones attach to thyroid hormone binding proteins, thyroxin-binding globulin, and thyroxin-binding prealbumin (transthyretin). Transport and binding to thyroid hormone receptors in the cytoplasm and nucleus then takes place. Thus by acting as a replacement for natural thyroxine, symptoms of thyroxine deficiency are relieved.
AbsorptionBioavailability varies from 48% to 80%. Human studies have confirmed the importance of an intact jejunum and ileum for levothyroxine absorption and have shown some absorption from the duodenum.
Volume of distributionNot Available
Protein binding> 99% to serum proteins, including thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (TBA)
Metabolism

Approximately 70% of secreted T4 is deiodinated to equal amounts of T3 and reverse triiodothyronine (rT3), which is calorigenically inactive. Elimination of T4 and T3 involves hepatic conjugation to glucuronic and sulfuric acids. The hormones undergo enterohepatic circulation as conjugates are hydrolyzed in the intestine and reabsorbed. Conjugated compounds that reach the colon are hydrolyzed and eliminated as free compounds in the feces. Other minor T4 metabolites have been identified.

Route of eliminationThyroid hormones are primarily eliminated by the kidneys.
Half lifeT4, 6 to 7 days. T3, 1 to 2 days.
ClearanceNot Available
ToxicityLD50=20 mg/kg (orally in rat). Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption + 0.7212
Blood Brain Barrier - 0.6886
Caco-2 permeable - 0.653
P-glycoprotein substrate Non-substrate 0.5321
P-glycoprotein inhibitor I Non-inhibitor 0.9175
P-glycoprotein inhibitor II Non-inhibitor 0.9709
Renal organic cation transporter Non-inhibitor 0.8891
CYP450 2C9 substrate Non-substrate 0.8309
CYP450 2D6 substrate Non-substrate 0.9116
CYP450 3A4 substrate Non-substrate 0.6847
CYP450 1A2 substrate Non-inhibitor 0.5924
CYP450 2C9 substrate Non-inhibitor 0.7037
CYP450 2D6 substrate Non-inhibitor 0.923
CYP450 2C19 substrate Non-inhibitor 0.9025
CYP450 3A4 substrate Non-inhibitor 0.831
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8459
Ames test Non AMES toxic 0.7591
Carcinogenicity Non-carcinogens 0.9148
Biodegradation Not ready biodegradable 0.9693
Rat acute toxicity 2.7082 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.9697
hERG inhibition (predictor II) Non-inhibitor 0.8508
Pharmacoeconomics
Manufacturers
  • Institute biochimique sa (ibsa)
  • Institut biochimique sa ibsa
  • Vintage pharmaceuticals llc
  • Alara pharmaceutical corporation
  • Lloyd inc
  • Merck kgaa
  • Mylan pharmaceuticals inc
  • King pharmaceuticals inc
  • Abbott laboratories
  • Jerome stevens pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral100 ug
Capsuleoral112 ug
Capsuleoral125 ug
Capsuleoral13 ug
Capsuleoral137 ug
Capsuleoral150 ug
Capsuleoral25 ug
Capsuleoral50 ug
Capsuleoral75 ug
Capsuleoral88 ug
Injection, powder, lyophilized, for solutionintravenous100 ug/5mL
Injection, powder, lyophilized, for solutionintravenous200 ug/5mL
Injection, powder, lyophilized, for solutionintravenous500 ug/5mL
Tabletoral.025 mg
Tabletoral.05 mg
Tabletoral.075 mg
Tabletoral.088 mg
Tabletoral.1 mg
Tabletoral.112 mg
Tabletoral.125 mg
Tabletoral.137 mg
Tabletoral.15 mg
Tabletoral.175 mg
Tabletoral.2 mg
Tabletoral.3 mg
Tabletoral100 ug
Tabletoral112 ug
Tabletoral125 ug
Tabletoral137 ug
Tabletoral150 ug
Tabletoral175 ug
Tabletoral200 ug
Tabletoral25 ug
Tabletoral300 ug
Tabletoral50 ug
Tabletoral75 ug
Tabletoral88 ug
Prices
Unit descriptionCostUnit
Levothyroxine sodium powder159.12USDg
Levothyroxine 200 mcg vial24.0USDvial
Levothyroxine 500 mcg vial24.0USDvial
Levoxyl 300 mcg tablet2.34USDtablet
Synthroid 300 mcg tablet1.29USDtablet
Synthroid 175 mcg tablet1.07USDtablet
Synthroid 200 mcg tablet0.99USDtablet
Synthroid 137 mcg tablet0.87USDtablet
Synthroid 112 mcg tablet0.84USDtablet
Synthroid 125 mcg tablet0.84USDtablet
Synthroid 150 mcg tablet0.83USDtablet
Levothyroxine Sodium 300 mcg tablet0.77USDtablet
Synthroid 100 mcg tablet0.73USDtablet
Synthroid 75 mcg tablet0.72USDtablet
Synthroid 88 mcg tablet0.71USDtablet
Levoxyl 200 mcg tablet0.7USDtablet
Levoxyl 175 mcg tablet0.69USDtablet
Unithroid 300 mcg tablet0.69USDtablet
Synthroid 50 mcg tablet0.65USDtablet
Levoxyl 137 mcg tablet0.62USDtablet
Unithroid 200 mcg tablet0.62USDtablet
Levoxyl 112 mcg tablet0.61USDtablet
Synthroid 25 mcg tablet0.61USDtablet
Unithroid 175 mcg tablet0.61USDtablet
Levoxyl 150 mcg tablet0.59USDtablet
Levoxyl 125 mcg tablet0.58USDtablet
Levothyroxine Sodium 175 mcg tablet0.57USDtablet
Levothyroxine Sodium 200 mcg tablet0.57USDtablet
Levothyroxine 175 mcg tablet0.55USDtablet
Unithroid 150 mcg tablet0.55USDtablet
Levoxyl 88 mcg tablet0.54USDtablet
Unithroid 112 mcg tablet0.53USDtablet
Unithroid 125 mcg tablet0.53USDtablet
Levoxyl 75 mcg tablet0.52USDtablet
Levothroid 300 mcg tablet0.51USDtablet
Levoxyl 100 mcg tablet0.51USDtablet
Levothyroxine Sodium 100 mcg tablet0.5USDtablet
Levothyroxine Sodium 150 mcg tablet0.5USDtablet
Levothyroxine Sodium 88 mcg tablet0.5USDtablet
Levoxyl 50 mcg tablet0.49USDtablet
Unithroid 88 mcg tablet0.49USDtablet
Unithroid 100 mcg tablet0.47USDtablet
Unithroid 75 mcg tablet0.47USDtablet
Levothyroxine Sodium 125 mcg tablet0.47USDtablet
Levothyroxine Sodium 137 mcg tablet0.47USDtablet
Levothyroxine Sodium 50 mcg tablet0.47USDtablet
Levothyroxine Sodium 75 mcg tablet0.47USDtablet
Levothyroxine Sodium 112 mcg tablet0.46USDtablet
Levothyroxine 137 mcg tablet0.45USDtablet
Levoxyl 25 mcg tablet0.45USDtablet
Levothyroxine 112 mcg tablet0.44USDtablet
Levothyroxine Sodium 25 mcg tablet0.43USDtablet
Unithroid 50 mcg tablet0.43USDtablet
Unithroid 25 mcg tablet0.42USDtablet
Unithroid direct 100 mcg tablet0.42USDtablet
Unithroid direct 112 mcg tablet0.42USDtablet
Unithroid direct 125 mcg tablet0.42USDtablet
Unithroid direct 150 mcg tablet0.42USDtablet
Unithroid direct 175 mcg tablet0.42USDtablet
Unithroid direct 200 mcg tablet0.42USDtablet
Unithroid direct 25 mcg tablet0.42USDtablet
Unithroid direct 300 mcg tablet0.42USDtablet
Unithroid direct 50 mcg tablet0.42USDtablet
Unithroid direct 75 mcg tablet0.42USDtablet
Unithroid direct 88 mcg tablet0.42USDtablet
Levothroid 200 mcg tablet0.4USDtablet
Levothroid 175 mcg tablet0.38USDtablet
Levothyroxine 88 mcg tablet0.38USDtablet
Levothroid 125 mcg tablet0.36USDtablet
Levothroid 150 mcg tablet0.36USDtablet
Levothroid 100 mcg tablet0.35USDtablet
Levothroid 137 mcg tablet0.35USDtablet
Levothroid 112 mcg tablet0.34USDtablet
Levothroid 75 mcg tablet0.33USDtablet
Levothroid 88 mcg tablet0.33USDtablet
Levothyroxine 300 mcg tablet0.32USDtablet
Levothroid 25 mcg tablet0.31USDtablet
Unithroid 137 mcg tablet0.31USDtablet
Levothroid 50 mcg tablet0.3USDtablet
Levothyroxine 200 mcg tablet0.29USDtablet
Levothyroxine 150 mcg tablet0.24USDtablet
Levothyroxine 125 mcg tablet0.22USDtablet
Levothyroxine 100 mcg tablet0.2USDtablet
Levothyroxine 75 mcg tablet0.2USDtablet
Levothyroxine 50 mcg tablet0.18USDtablet
Synthroid 0.137 mg Tablet0.18USDtablet
Levothyroxine 25 mcg tablet0.17USDtablet
Synthroid 0.3 mg Tablet0.12USDtablet
Synthroid 0.175 mg Tablet0.11USDtablet
Synthroid 0.075 mg Tablet0.1USDtablet
Synthroid 0.088 mg Tablet0.1USDtablet
Synthroid 0.112 mg Tablet0.1USDtablet
Synthroid 0.125 mg Tablet0.1USDtablet
Synthroid 0.025 mg Tablet0.09USDtablet
Synthroid 0.2 mg Tablet0.09USDtablet
Synthroid 0.1 mg Tablet0.08USDtablet
Synthroid 0.15 mg Tablet0.08USDtablet
Eltroxin 0.3 mg Tablet0.07USDtablet
Synthroid 0.05 mg Tablet0.06USDtablet
Eltroxin 0.2 mg Tablet0.05USDtablet
Eltroxin 0.1 mg Tablet0.04USDtablet
Eltroxin 0.15 mg Tablet0.04USDtablet
Eltroxin 0.05 mg Tablet0.03USDtablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States63991012000-03-302020-03-30
United States77233902004-03-142024-03-14
Properties
Statesolid
Experimental Properties
PropertyValueSource
melting point235.5 °CPhysProp
water solubility0.105 mg/mLNot Available
logP4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00898ALOGPS
logP1.15ALOGPS
logP3.73ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)0.27ChemAxon
pKa (Strongest Basic)9.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.78 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity126.79 m3·mol-1ChemAxon
Polarizability49.4 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
SpectraMS/MS1D NMR2D NMR
References
Synthesis Reference

Jivn-Ren Chen, Dimitri C. Papadimitriou, “Stable dosage of levothyroxine sodium and process of production.” U.S. Patent US5225204, issued November, 1991.

US5225204
General Reference
  1. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. Pubmed
External Links
ResourceLink
KEGG CompoundC01829
PubChem Compound5819
PubChem Substance46507672
ChemSpider5614
ChEBI18332
ChEMBLCHEMBL1624
Therapeutic Targets DatabaseDAP000083
PharmGKBPA450221
IUPHAR2635
Guide to Pharmacology2635
RxListhttp://www.rxlist.com/cgi/generic/levothy.htm
Drugs.comhttp://www.drugs.com/levothyroxine.html
PDRhealthhttp://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/syn1421.shtml
WikipediaLevothyroxine
ATC CodesH03AA01
AHFS Codes
  • 68:36.04
PDB EntriesNot Available
FDA labelshow(54.3 KB)
MSDSshow(51.7 KB)
Interactions
Drug Interactions
Drug
AcenocoumarolThe thyroid hormone, levothyroxine, increase the anticoagulant effect of acenocoumarol.
AnisindioneThe thyroid hormone, levothyroxine, increase the anticoagulant effect of anisindione.
CalciumCalcium decreases absorption of levothyroxine
Calcium AcetateCalcium salts such as calcium acetate may diminish the therapeutic effect of thyroid products such as levothyroxine. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
Calcium ChlorideCalcium salts such as calcium chloride may diminish the therapeutic effect of thyroid products such as levothyroxine. Separate the doses of the thyroid product and the oral calcium supplement by at least 4 hours. Monitor for decreased therapeutic effects of thyroid products if an oral calcium supplement is initiated/dose increased, or increased effects if an oral calcium supplement is discontinued/dose decreased.
CholestyramineThe resin, cholestyramine, decreases the absorption of the thyroid hormone, levothyroxine.
ColestipolThe resin, colestipol, decreases the absorption of the thyroid hormone, levothyroxine.
DicoumarolThe thyroid hormone, levothyroxine, increase the anticoagulant effect of dicumarol.
DigoxinThe thyroid hormone, levothyroxine, decreases the effect of digoxin.
IronIron decreases absorption of levothyroxine
Iron DextranIron decreases the absorption of levothyroxine
RaloxifeneRaloxifene decreases absorption of levothyroxine
SucralfateSucralfate decreases the effect of levothyroxine
WarfarinLevothyroxine may contribute to the anticoagulant effect of warfarin by increasing the metabolism of vitamin K-dependent clotting factors. Monitor for changes in prothrombin time and anticoagulant effects if levothyroxine is initiated, discontinued or dose changed.
Food Interactions
  • Absorption increased in fasting state and decreased in malabsorption states.
  • Consistent administration in relation to meals is recommended.
  • No iron or calium carbonate within 4 hours of taking this medication.
  • Oral administration with infant soybean formula, soybean flour, cotton seed meal, walnuts, foods containing large amounts of fiber, ferrous sulfate, and antacids may decrease drug absorption.
  • Take 30-60 minutes before breakfast.

Targets

1. Thyroid hormone receptor alpha

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Thyroid hormone receptor alpha P10827 Details

References:

  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  3. Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59. Pubmed
  4. Nakajima Y, Yamada M, Horiguchi K, Satoh T, Hashimoto K, Tokuhiro E, Onigata K, Mori M: Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor. Thyroid. 2010 Aug;20(8):917-26. Pubmed
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

2. Thyroid hormone receptor beta

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Thyroid hormone receptor beta P10828 Details

References:

  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  2. Marazuela M, Nattero L, Moure D, Garcia-Polo I, Figueroa-Vega N, Guijarro C: Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23. Pubmed
  3. Sivakumar T, Chaidarun S: Resistance to thyroid hormone in a patient with coexisting Graves’ disease. Thyroid. 2010 Feb;20(2):213-6. Pubmed
  4. Grasberger H, Ringkananont U, Croxson M, Refetoff S: Resistance to thyroid hormone in a patient with thyroid dysgenesis. Thyroid. 2005 Jul;15(7):730-3. Pubmed

Enzymes

1. Cytochrome P450 2C8

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. Pubmed

2. Cytochrome P450 3A4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Carriers

1. Transthyretin

Kind: protein

Organism: Human

Pharmacological action: no

Components

Name UniProt ID Details
Transthyretin P02766 Details

References:

  1. Eneqvist T, Lundberg E, Karlsson A, Huang S, Santos CR, Power DM, Sauer-Eriksson AE: High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine. J Biol Chem. 2004 Jun 18;279(25):26411-6. Epub 2004 Apr 13. Pubmed
  2. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. Pubmed

2. Thyroxine-binding globulin

Kind: protein

Organism: Human

Pharmacological action: no

Components

Name UniProt ID Details
Thyroxine-binding globulin P05543 Details

References:

  1. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. Pubmed

3. Serum albumin

Kind: protein

Organism: Human

Pharmacological action: no

Components

Name UniProt ID Details
Serum albumin P02768 Details

References:

  1. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. Pubmed

Transporters

1. Solute carrier organic anion transporter family member 1C1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 1C1 Q9NYB5 Details

References:

  1. Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. Epub 2008 Oct 9. Pubmed
  2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed
  3. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. Pubmed

2. Monocarboxylate transporter 8

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Monocarboxylate transporter 8 P36021 Details

References:

  1. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ: Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem. 2003 Oct 10;278(41):40128-35. Epub 2003 Jul 18. Pubmed

3. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inducer

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Siegmund W, Altmannsberger S, Paneitz A, Hecker U, Zschiesche M, Franke G, Meng W, Warzok R, Schroeder E, Sperker B, Terhaag B, Cascorbi I, Kroemer HK: Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition. Clin Pharmacol Ther. 2002 Sep;72(3):256-64. Pubmed

4. Solute carrier organic anion transporter family member 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 1A2 P46721 Details

References:

  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. Pubmed

5. Solute carrier organic anion transporter family member 1B1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 1B1 Q9Y6L6 Details

References:

  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. Pubmed

6. Solute carrier organic anion transporter family member 1B3

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 1B3 Q9NPD5 Details

References:

  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. Pubmed

7. Solute carrier organic anion transporter family member 4A1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 4A1 Q96BD0 Details

References:

  1. Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. Pubmed

8. Solute carrier organic anion transporter family member 4C1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Solute carrier organic anion transporter family member 4C1 Q6ZQN7 Details

References:

  1. Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. Pubmed

9. Large neutral amino acids transporter small subunit 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Components

Name UniProt ID Details
Large neutral amino acids transporter small subunit 1 Q01650 Details

References:

  1. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:10