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NamePotassium Iodide
Accession NumberDB06715
TypeSmall Molecule

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperglycemia (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.

Potassium iodide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Thyrosafetablet65 mgoralRecip Ab2003-11-042008-07-07Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Iosattablet65 mg/1oralAnbex Inc.2013-05-01Not applicableUs
Iosattablet130 mg/1oralAnbex Inc.1982-10-14Not applicableUs
Thyroblock Tab 130mgtablet130 mgoralCarter Horner Corp.1981-12-312003-03-14Canada
Thyroshieldsolution65 mg/mLoralFleming & Company, Pharmaceuticals2005-04-01Not applicableUs
Thyroshieldsolution65 mg/mLoralArco Pharmaceuticals LLC2014-09-01Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sskisolution1 g/mLoralUpsher Smith Laboratories, Inc.1973-04-30Not applicableUs
International BrandsNot Available
Brand mixtures
Citranatal DHAMission Pharmacal Company
Citranatal RxMission Pharmacal Company
DiodineProduits Marc O (1987) Inc., Division Of Technilab Inc.
Foltabs PrenatalMidlothian Laboratories
Fusion Activator Formula TabL & S Research Corporation
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemenatal ObWh Nutritionals, Llc
Humco Strong Iodine SolutionHumco Holding Group, Inc.
Humco Strong Iodine TinctureHumo Holding Group, Inc.
Hypo Vites TabPharmetics (2011) Inc
I D M Expectorant TabRougier Pharma Division Of Ratiopharm Inc
I.D.M. SolutionRougier Pharma Division Of Ratiopharm Inc
Idm TabRougier Pharma Division Of Ratiopharm Inc
Inatal UltraNnodum Pharmaceuticals
IodineBorisovskiy Zavod Medicinskikh Preparatov Jsc
Iodine Tct 2.5% BPStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Iodine Tct 5% CFStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Iodine Tincture 21/2%Ingram And Bell Inc.
Iron Polysaccharides Folic Acid DHAVirtus Pharmaceuticals LLC
Kanga-V Multivitamins & MineralsLacombe Drugs (1992) Ltd
Lugols Strong IodineCooper Surgical, Inc.
M.T.E.-6 ConcentratedLyphomed, Division Of Fujisawa Canada Inc.
Mathieu Cough SyrupJ L Mathieu Cie Ltee
MetrateMedic Laboratory LtÉe
Mor-vites TabPharmetics (2011) Inc
Multi Vitamin-mineral FormulaVita Health Products Inc
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc
One A Day Advance AdultsBayer Inc Consumer Care
One A Day Advance Adults 50+Bayer Inc Consumer Care
PhytopureLaboratoire Lalco Inc.
Pnv-firstAcella Pharmaceuticals, LLC
Pnv-selectAcella Pharmaceuticals, LLC
Prefera Ob Plus DHAAlaven Pharmaceutical LLC
PreferaobMEDA Pharmaceuticals
Preferaob OneMEDA Pharmaceuticals
Preferaob Plus DHAAlaven Pharmaceutical LLC
PregvitDuchesnay Inc
Pregvit Folic 4Duchesnay Inc
Pregvit Folic 5Duchesnay Inc
Prenatal Chelated MineralUsana Health Sciences, Inc.
Prenate EliteAvion Pharmaceuticals, Llc
Prenate EnhanceAvion Pharmaceuticals, Llc
Prenate EssentialAvion Pharmaceuticals, Llc
Prenate PixieAvion Pharmaceuticals, Llc
Prenate StarAvion Pharmaceuticals, Llc
PretabVirtus Pharmaceuticals LLC
Q.T. Vitamin and Mineral Drink MixGarden State Nutritionals
Ratio-theo-broncRatiopharm Inc Division Of Teva Canada Limited
Revival 1 TabBio Vita
Spectrum 2 CapNf Formulas Inc.
Super Daily No 2W.R. Enterprises Inc.
Tincture Of IodineLawton's Drug Stores Ltd.
Tincture Of Iodine 2.5%D.C. Labs Limited
Tincture Of Iodine 5%D.C. Labs Limited
V-natalVirtus Pharmaceuticals
Virt-PNVirtus Pharmaceuticals
Virt-PN PlusVirtus Pharmaceuticals LLC
Vitafol UltraEverett Laboratories, Inc.
Vito Bronches SiropDuchesnay Inc
Vp-heme ObVirtus Pharmaceuticals LLC
Vp-heme OneVirtus Pharmaceuticals LLC
SaltsNot Available
CAS number7681-11-0
WeightAverage: 166.0028
Monoisotopic: 165.868175281
Chemical FormulaIK
potassium iodide
DescriptionThis compound belongs to the class of inorganic compounds known as alkali metal iodides. These are inorganic compounds in which the largest halogen atom is Iodine, and the heaviest metal atom is an alkali metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassAlkali metal salts
Sub ClassAlkali metal iodides
Direct ParentAlkali metal iodides
Alternative Parents
  • Alkali metal iodide
  • Inorganic salt
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
IndicationPotassium Iodide is oral antithyroid agent. Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.
PharmacodynamicsIt works in the thyroid gland. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.
Mechanism of actionNot Available
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Predicted ADMET features
Human Intestinal Absorption+0.7647
Blood Brain Barrier+0.9702
Caco-2 permeable+0.6625
P-glycoprotein substrateNon-substrate0.8989
P-glycoprotein inhibitor INon-inhibitor0.984
P-glycoprotein inhibitor IINon-inhibitor0.9854
Renal organic cation transporterNon-inhibitor0.9282
CYP450 2C9 substrateNon-substrate0.8261
CYP450 2D6 substrateNon-substrate0.7789
CYP450 3A4 substrateNon-substrate0.7857
CYP450 1A2 substrateNon-inhibitor0.7164
CYP450 2C9 inhibitorNon-inhibitor0.8527
CYP450 2D6 inhibitorNon-inhibitor0.9142
CYP450 2C19 inhibitorNon-inhibitor0.8842
CYP450 3A4 inhibitorNon-inhibitor0.9317
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9022
Ames testNon AMES toxic0.6838
CarcinogenicityCarcinogens 0.659
BiodegradationNot ready biodegradable0.5913
Rat acute toxicity2.9202 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9535
hERG inhibition (predictor II)Non-inhibitor0.9657
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
ManufacturersNot Available
PackagersNot Available
Dosage forms
Tabletoral130 mg/1
Tabletoral65 mg/1
Tablet (effervescent)oral
Tablet, coatedoral
Capsule, liquid filledoral
Solutionoral1 g/mL
Tabletoral130 mg
Tabletoral65 mg
Solutionoral65 mg/mL
Tablet, film coatedoral
Capsule, gelatin coatedoral
PricesNot Available
PatentsNot Available
Experimental PropertiesNot Available
Predicted Properties
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Mass Spec (NIST)Not Available
SpectraNot Available
Synthesis Reference

Stanley D. Lazarus, “Production of thermally stabilized polyester with alkylene carbonates and sodium or potassium iodide.” U.S. Patent US4327207, issued October, 1973.

General ReferencesNot Available
External Links
ATC CodesR05CA02S01XA04V03AB21
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Drug Interactions
AliskirenPotassium Iodide may increase the hyperkalemic activities of Aliskiren.
ArdeparinArdeparin may increase the hyperkalemic activities of Potassium Iodide.
DicoumarolPotassium Iodide may decrease the anticoagulant activities of Dicoumarol.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Potassium Iodide.
EplerenoneEplerenone may increase the hyperkalemic activities of Potassium Iodide.
HeparinHeparin may increase the hyperkalemic activities of Potassium Iodide.
LithiumPotassium Iodide may increase the hypothyroid activities of Lithium.
NicorandilNicorandil may increase the hyperkalemic activities of Potassium Iodide.
PerindoprilPotassium Iodide may increase the hyperkalemic activities of Perindopril.
Sodium Iodide I-131The therapeutic efficacy of Sodium Iodide I-131 can be decreased when used in combination with Potassium Iodide.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Potassium Iodide.
TriamterenePotassium Iodide may increase the hyperkalemic activities of Triamterene.
ValsartanPotassium Iodide may increase the hyperkalemic activities of Valsartan.
Food InteractionsNot Available


Small molecule
Pharmacological action
  1. Pisarev MA, Aiello LO: Studies on the mechanism of action of potassium iodide on thyroid protein biosynthesis. Acta Endocrinol (Copenh). 1976 Jun;82(2):298-305. [PubMed:946922 ]
  2. Foldes J, Gesztesi E, Juhasz J: Mechanism of action of di-iodotyrosine and of iodine. Acta Med Acad Sci Hung. 1974;31(1-2):131-7. [PubMed:4464746 ]
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Drug created on May 16, 2010 17:39 / Updated on September 16, 2013 18:04