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Identification
NameLoratadine
Accession NumberDB00455  (APRD00384)
TypeSmall Molecule
GroupsApproved
Description

Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem]

Structure
Thumb
Synonyms
Claritin
Loratadina
Loratadinum
External Identifiers Not Available
Prescription ProductsNot Available
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Loratadinetablet10 mg/1oralNorthwind Pharmaceuticals, LLC2014-10-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Allergy Relieftablet10 mg/1oralClinical Solutions Wholesale2003-08-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Antihistaminetablet10 mg/1oralbryant ranch prepack2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadineantihistamine Antihistaminetablet10 mg/1oralREMEDYREPACK INC.2013-05-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadineantihistamine Antihistaminetablet10 mg/1oralREMEDYREPACK INC.2014-02-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Allergy Relieftablet10 mg/1oralMeijer Distribution Inc2014-12-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
24 Hour Allergy Remedytablet10 mgoralVita Health Products Inc2006-07-28Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
7 Select Allergy Relieftablet10 mg/1oral7 Eleven2014-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Alavert Allergytablet, orally disintegrating10 mg/1oralPfizer Consumer Healthcare2002-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Alavert Allergytablet, orally disintegrating10 mg/1oralPfizer Consumer Healthcare2002-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allegy Relief 24 Hour Non Drowsytablet10 mg/1oralHannaford Brothers Company2006-09-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergytablet10 mg/1oralMajor Pharmaceuticals2005-02-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Reliefsolution5 mg/5mLoralKroger Company2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Reliefsolution5 mg/5mLoralMedicine Shoppe International Inc2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralNovartis Consumer Health, Inc.2010-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralAllegiant Health2014-12-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralRite Aid Corporation2004-10-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralHy Vee Inc2005-05-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet, orally disintegrating10 mg/1oralCardinal Health2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralSafeway2013-07-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet, orally disintegrating10 mg/1oralOhm Laboratories Inc.2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralGeri Care Pharmaceutical Corp2008-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralNovartsi Consumer Health, Inc.2010-01-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralKroger Company2005-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralShopko Stores Operating Co., LLC2013-09-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralCVS Pharmacy2005-01-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relieftablet10 mg/1oralMeijer Distribution Inc2007-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relief 24 Hourtablet10 mg/1oralWestern Family Foods Inc2005-04-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relief Childrenssolution5 mg/5mLoralH E B2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relief Childrenssolution5 mg/5mLoralH E B2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relief Medicationtablet10 mg/1oralTarget Brands, Inc.2010-01-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Relief Non Drowsytablet10 mg/1oralSelect Corporation2012-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Allergy Remedytablet10 mgoralApotex Inc2013-05-23Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Allertintablet10 mgoralApotex IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Allertincapsule10 mgoralApotex Inc2013-10-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Allertin Tablets 10mgtablet10 mgoralVita Health Products Inc2002-01-012008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-loratadinetablet10 mgoralApotex Inc2001-06-27Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bactimicina Allergytablet10 mg/1oralDLC Laboratories, Inc.2009-10-212017-01-01Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Being Well Allergy Relieftablet10 mg/1oralSave A Lot Food Stores Ltd2006-02-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Allergy Relieftablet10 mg/1oralBJWC2009-04-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Berkley and Jensen Loratadine Non Drowsytablet10 mg/1oralBJWC2009-04-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Best Choice Childrens Loratadinesolution5 mg/5mLoralValu Merchandisers Company2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Best Choice Childrens Loratadine Sugar Freesolution5 mg/5mLoralValu Merchandisers Company2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Care One Childrens Loratadinesolution5 mg/5mLoralAmerican Sales Company2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Careone Allergy Relief 24 Hourtablet10 mg/1oralAmerican Sales Company2006-06-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Children Claritin Allergysolution5 mg/5mLoralBayer Health Care Consumer Care2015-05-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens 24 Hour Allergysolution5 mg/5mLoralMeijer Distribution Inc2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergysolution5 mg/5mLoralPublix Super Markets Inc2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergy Dye Freeliquid5 mg/5mLoralTarget Corporation2014-10-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergy Dye Freeliquid5 mg/5mLoralQUALITY CHOICE (Chain Drug Marketing Association)2015-01-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergy Reliefsolution5 mg/5mLoralCVS Pharmacy2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergy Reliefsolution5 mg/5mLoralRite Aid Corporation2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergy Reliefsolution5 mg/5mLoralWal Mart Stores Inc2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergy Reliefsolution5 mg/5mLoralSupervalu Inc2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergy Reliefsolution5 mg/5mLoralRite Aid Corporation2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Allergy Reliefsolution5 mg/5mLoralCVS Pharmacy2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralKinray, Inc.2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralTaro Pharmaceuticals U.S.A., Inc.2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralTarget Corporation2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralTaro Pharmaceuticals U.S.A., Inc.2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralAmerican Sales Company2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralTarget Corporation2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralAidarex Pharmaceuticals LLC2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralRite Aid Corporation2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Loratadinesolution5 mg/5mLoralTaro Pharmaceuticals U.S.A., Inc.2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Non-drowsy 24-hour Allergy Reliefsolution5 mg/5mLoralSafeway Inc.2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Non-drowsy 24-hour Allergy Reliefsolution5 mg/5mLoralSafeway Inc.2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Non-drowsy Allergy Relief 24-hoursolution5 mg/5mLoralKroger Company2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Childrens Wal-itinsolution5 mg/5mLoralWalgreen Company2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritinsolution5 mg/5mLoralBayer Health Care Llc2011-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritintablet, chewable5 mg/5mgoralBayer Health Care Llc2015-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritintablet10 mgoralBayer Inc Consumer Care1988-12-18Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Claritintablet, chewable5 mg/1oralMSD Consumer Care, Inc.2006-08-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritintablet, chewable5 mg/1oralMSD Consumer Care, Inc.2009-03-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritin Antihistaminetablet10 mg/1oralLil' Drug Store Products, Inc2004-11-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritin Kidssyrup1 mgoralBayer Inc Consumer Care2000-04-06Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Claritin Liqui-gelscapsule, liquid filled10 mg/1oralMSD Consumer Care, Inc.2008-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritin Liquid Capsulescapsule10 mgoralBayer Inc Consumer Care2013-07-01Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Claritin Rapid Dissolvetablet (orally disintegrating)10 mgoralBayer Inc Consumer Care1998-05-05Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Claritin Rapid Dissolvetablet (orally disintegrating)5 mgoralBayer Inc Consumer CareNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Claritin Reditabstablet, orally disintegrating5 mg/1oralMSD Consumer Care, Inc.2006-12-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritin Reditabstablet, orally disintegrating10 mg/1oralMSD Consumer Care, Inc.2002-11-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritin Reditabstablet, orally disintegrating10 mg/1oralMSD Consumer Care, Inc.2002-11-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Claritin Syrup 1mg/mlsyrup1 mgoralSchering Plough Canada Inc1993-12-312012-07-24Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Cleartimetablet10 mg/1oralWestern Family Foods Inc2015-03-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Cleartimetablet10 mg/1oralHy Vee Inc2015-02-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Counteract Allergytablet10 mg/1oralMelaleuca, Inc.2008-06-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dg Health Allergy Relieftablet10 mg/1oralDolgencorp, LLC2012-04-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Allergy Relieftablet10 mg/1oralSupervalu Inc2005-02-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Allergy Relief Non Drowsytablet, orally disintegrating10 mg/1oralSupervalu Inc2004-08-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equaline Childrens Loratadinesolution5 mg/5mLoralSupervalu Inc2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Allergy Relieftablet10 mg/1oralWal Mart Stores Inc2007-04-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Equate Childrens Allergy Reliefsolution5 mg/5mLoralWal Mart Stores Inc2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Exchange Select Allergy Relieftablet10 mg/1oralArmy & Air Force Exchange Service2008-08-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Fad First Aid Direct Allergy Relieftablet10 mg/1oralFirst Aid Direct2012-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Family Dollar Allergy Relieftablet10 mg/1oralNovartis Consumer Health, Inc.2004-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Formucare Allergy Relieftablet10 mg/1oralAccess Business Group LLC2005-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Allergy Relieftablet, orally disintegrating10 mg/1oralAmerisource Bergen2004-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Childrens Loratadinesolution5 mg/5mLoralAmerisource Bergen2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Childrens Loratadinesolution5 mg/5mLoralAmerisource Bergen2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Childrens Loratadinesolution5 mg/5mLoralAmerisource Bergen2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Cleartimetablet10 mg/1oralAmerisource Bergen2015-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Neighbor Pharmacy Loratadinetablet10 mg/1oralAmerisource Bergen2008-11-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Allergy Relieftablet10 mg/1oralL. Perrigo Company2004-09-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Good Sense Childrens Loratadinesolution5 mg/5mLoralGeiss, Destin & Dunn, Inc.2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Harmon Face Values Allergy Relieftablet10 mg/1oralHarmon Stores Inc.2011-12-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Harris Teeter Allergy Relieftablet10 mg/1oralHarris Teeter, LLC2015-06-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Allergy Relieftablet10 mg/1oralMc Kesson2012-01-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Loratadinetablet10 mg/1oralMc Kesson2014-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Health Mart Pharmacy Childrens Loratadinesolution5 mg/5mLoralHealth Mart2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthmart Childrens Loratadinesolution5 mg/5mLoralMc Kesson2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthmart Loratadine ODTtablet, orally disintegrating10 mg/1oralHealth Mart2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Healthy Accents Allergy Relieftablet10 mg/1oralDZA Brands LLC2007-12-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Help I Have Allergiestablet10 mg/1oralHelp Remedies, Inc.2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Hy-vee Childrens Loratadinesolution5 mg/5mLoralHyVee Inc2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Kirkland Signature Allercleartablet10 mg/1oralCostco Wholesale Company2007-05-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Allergy Relieftablet, orally disintegrating10 mg/1oralCardinal Health2004-02-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Allergy Relieftablet, orally disintegrating10 mg/1oralCardinal Health2004-02-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Allergy Relieftablet10 mg/1oralCardinal Health2014-07-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Childrens Allergy Reliefsolution5 mg/5mLoralCardinal Health2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Leader Loratadinetablet10 mg/1oralCardinal Health2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Live Better Loratadinesolution5 mg/5mLoralThe Great Atlantic & Pacific Tea Company2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralSandoz Inc2003-01-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralSelect Brand2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralCVS Pharmacy2010-01-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralAmerican Health Packaging2013-06-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralChain Drug Marketing Association Inc.2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinesolution5 mg/5mLoralRebel Distributors Corp2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinesolution5 mg/5mLoralSilarx Pharmaceuticals, Inc2010-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralAmerican Sales Company2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralValu Merchandisers Company2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralWalgreen Company2013-12-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralBlenheim Pharmacal, Inc.2014-02-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralCardinal Health2005-01-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralShopko Stores Operating Co., LLC2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinesolution5 mg/5mLoralSilarx Pharmaceuticals, Inc2010-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinesolution5 mg/5mLoralPreferred Pharmaceuticals, Inc.2012-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralValu Merchandisers Company2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralKAISER FOUNDATION HOSPITALS2011-02-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralFamily Dollar Services, Inc.2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralCardinal Health2009-11-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralMylan Pharmaceuticals Inc.2013-03-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralInnovative Manufacturing and Distribution Services, Inc.2008-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralSUPERVALU INC.2013-12-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralNorthstar Rx LLC2016-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralCardinal Health2013-06-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinesolution5 mg/5mLoralMajor Pharmaceuticals, Inc2011-02-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralPublix Super Markets Inc2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralGood Neighbor Pharmacy2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralCardinal Health2013-04-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralSUPERVALU INC.2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-02-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralFred's Inc.2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralMajor Pharmaceuticals2003-08-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralSafeway Inc.2009-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralKinray2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralMedline Industries, Inc.2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralDLC Laboratories, Inc2009-06-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralTarget Corporation2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralCardinal Health2003-01-212015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralOhm Laboratories Inc.2009-06-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralNovartis Consumer Health, Inc.2004-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralApotex Corp.2005-01-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralChain Drug Marketing Association Inc.2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralTarget Corporation2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinesolution5 mg/5mLoralPhysicians Total Care, Inc.2006-04-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralMc Kesson Contract Packaging2011-09-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralAmerican Sales Company2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mgoralApotex Inc2013-04-18Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Loratadinetablet10 mg/1oralAmerisource Bergen2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-01-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralSelect Brand2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralH.J. Harkins Company, Inc.2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinesolution5 mg/5mLoralCardinal Health2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralNovartis Consumer Health, Inc.2004-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralTopcare Associates LLC2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralRebel Distributors Corp2010-01-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralPhysicians Total Care, Inc.2005-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralAmerican Sales Company2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralMylan Institutional Inc.2013-04-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Loratadinetablet, orally disintegrating10 mg/1oralWalgreen Company2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralGood Neighbor Pharmacy2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralCardinal Health2011-06-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet, orally disintegrating10 mg/1oralGood Neighbor Pharmacy2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadinetablet10 mg/1oralPremier Value2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Allergy Relieftablet10 mg/1oralWin Co Foods, Llc2003-08-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Allergy Relieftablet10 mg/1oralProficient Rx LP2003-08-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Allergy Relieftablet10 mg/1oralOhm Laboratories Inc.2003-08-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Allergy Relieftablet10 mg/1oralWin Co Foods, Llc2003-08-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Antihistaminetablet10 mg/1oralPerrigo New York Inc2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Antihistaminetablet10 mg/1oralProficient Rx LP2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Antihistaminetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Antihistaminetablet10 mg/1oralUnit Dose Services2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Antihistaminetablet10 mg/1oralUnit Dose Services2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Antihistaminetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Antihistaminetablet10 mg/1oralCardinal Health2008-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODtablet, orally disintegrating10 mg/1oralFred's Inc.2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODTtablet, orally disintegrating10 mg/1oralMeijer Distribution, Inc.2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODTtablet, orally disintegrating10 mg/1oralSafeway Inc.2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODTtablet, orally disintegrating10 mg/1oralMajor Pharmaceuticals2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODTtablet, orally disintegrating10 mg/1oralTopco Associates LLC2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODTtablet, orally disintegrating10 mg/1oralChain Drug Consortium, LLC2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODTtablet, orally disintegrating10 mg/1oralMeijer Distribution, Inc.2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODTtablet, orally disintegrating10 mg/1oralCVS Pharmacy2007-09-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine ODTtablet, orally disintegrating10 mg/1oralShopko Stores Operating Co., LLC2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Loratadine Soft Gel Capsulecapsule10 mgoralApotex Inc2012-09-07Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Loratadine Tablets 10mgtablet10 mgoralVita Health Products Inc2002-01-012008-08-05Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Loratadineantihistamine Antihistaminetablet10 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Medicine Shoppe Loratadine Allergy Relieftablet10 mg/1oralThe Medicine Shoppe International2003-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Medique Loradamedtablet, film coated10 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Meijer Childrens 24 Hour Allergysolution5 mg/5mLoralMeijer Distribution Inc2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Members Mark Loratadinetablet10 mg/1oralSam's West Inc2007-05-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Moore Medical Loratadinetablet, film coated10 mg/1oralMoore Medical LLC2008-12-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Novo-loratadinetablet10 mgoralNovopharm LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Preferred Plus (kinray) Childrens Loratadinesolution5 mg/5mLoralPreferred Plus (Kinray)2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Preferred Plus Allergy Relieftablet10 mg/1oralKinray2014-09-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Premier Value Childrens Loratadinesolution5 mg/5mLoralChain Drug Constortium2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Premier Value Childrens Loratadinesolution5 mg/5mLoralChain Drug Constortium2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Quality Choice Childrens Allergy Reliefsolution5 mg/5mLoralChain Drug Marketing Association2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Quality Choice Childrens Allergy Reliefsolution5 mg/5mLoralChain Drug Marketing Association, Inc.2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Rexall Allergy Relief Non Drowsytablet10 mg/1oralDolgencorp, LLC2010-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Shoprite Allergy Relieftablet10 mg/1oralWakefern Food Corporation2013-08-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Simply Right Loratadinetablet10 mg/1oralSam's West Inc2014-01-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Smart Sense Allergy Relief Non Drowsytablet10 mg/1oralKmart Corporation2010-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sound Body Allergy Relieftablet10 mg/1oralBig Lots Stores, Inc.2015-06-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Allergy Relieftablet, orally disintegrating10 mg/1oralMc Kesson2004-02-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Childrens Loratadinesolution5 mg/5mLoralMc Kesson2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Childrens Loratadinesolution5 mg/5mLoralMc Kesson2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Childrens Loratadinesolution5 mg/5mLoralMc Kesson2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Loratadinetablet10 mg/1oralMc Kesson2007-06-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Loratadine Allergy Relieftablet, orally disintegrating10 mg/1oralMc Kesson2004-02-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Loratadine ODTtablet, orally disintegrating10 mg/1oralSunmark2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sunmark Loratadine ODTtablet, orally disintegrating10 mg/1oralSunmark2007-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Taro-loratadinetablet10 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Topcare Allergy Relieftablet, orally disintegrating10 mg/1oralTopco Associates LLC2004-02-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Allergy Relieftablet, orally disintegrating10 mg/1oralTopco Associates LLC2004-03-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Allergy Relief 24 Hourtablet10 mg/1oralTopco Associates LLC2005-01-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Childrens Allergy Relief 24 Hour Non Drowsytablet, orally disintegrating10 mg/1oralTopco Associates LLC2005-03-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Childrens Loratadinesolution5 mg/5mLoralTopco Associates LLC2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Topcare Clear Timetablet10 mg/1oralTopco Associates LLC2015-01-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Allergy Relieftablet, orally disintegrating10 mg/1oralTarget Corporation2009-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Up and Up Allergy Relieftablet10 mg/1oralTarget Corporation2012-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Vicks Qlearquil All Day and All Night 24 Hour Allergy Relieftablet10 mg/1oralThe Procter & Gamble Manufacturing Company2014-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Wal Itintablet10 mg/1oralWalgreen Company2009-02-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Wal Itintablet10 mg/1oralWalgreen Company2009-02-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Wal-itin Allergy Reliefsolution5 mg/5mLoralWalgreen Company2004-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Welby Health Allergy Relieftablet10 mg/1oralAldi, Inc2007-04-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Western Family Childrens Allergy Reliefsolution5 mg/5mLoralWestern Family Foods Inc2010-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
International Brands
NameCompany
AerotinaNot Available
AlavertNot Available
BiloinaNot Available
CiveranNot Available
FristaminNot Available
HistaloranNot Available
LomilanNot Available
LoracertNot Available
LoradexNot Available
LoranoxNot Available
LorastineNot Available
LoratyneNot Available
LoritineNot Available
NularefNot Available
RestamineNot Available
RoletraNot Available
SensibitNot Available
Brand mixtures
NameLabellerIngredients
Alavert Allergy Sinus D-12Wyeth Consumer Healthcare
Allergy and Congestion ReliefL. Perrigo Company
Allergy and Congestion Relief Non DrowsyAmerisource Bergen
Allergy Relief DShopko Stores Operating Co., LLC
Allergy Relief D 12CVS Pharmacy
Allergy Relief D 12 HourPublix Super Markets Inc
Allergy Relief D 24 HourPublix Super Markets Inc
Allergy Relief-DCVS Pharmacy
Careone Allergy and Congestion ReliefAmerican Sales Company
Chlor-tripolon Nd SrtSchering Plough Canada Inc
Claritin Allergy + SinusBayer Inc Consumer Care
Claritin Allergy + Sinus Extra StrengthBayer Inc Consumer Care
Claritin-D 12 HourMSD Consumer Care, Inc.
Claritin-D 24 HourMSD Consumer Care, Inc.
Equaline Allergy and Congestion ReliefSupervalu Inc
Good Neighbor Pharmacy Loratadine DAmerisource Bergen
Good Neighbor Pharmacy Loratadine D 24 HourAmerisource Bergen
Good Sense Allergy and Congestion ReliefL Perrigo Company
Good Sense Allergy and Congestion Relief Non Drowsy 24 HourL Perrigo Company
Health Mart Allergy and CongestionMc Kesson
Healthy Accents Allergy and Congestion Relief 24 Hour Non DrowsyDZA Brands LLC
Kirkland Signature Allerclear D 12 HrCostco Wholesale Company
Kirkland Signature Allerclear D 24hrCostco Wholesale Company
Leader Allergy Relief D-24Cardinal Health
LiberatorSchering Plough Canada Inc
Loratadine and PseudoephedrineWalgreen Company
Loratadine and Pseudoephedrine SulfateMajor Pharmaceuticals
Loratadine DPerrigo New York Inc
Loratadine D 24 HourPerrigo New York Inc
Medicine Shoppe Allergy Relief D24The Medicine Shoppe International
Preferred Plus Allergy and Congestion ReliefKinray
Shoprite Allergy and Congestion ReliefWakefern Food Corporation
Signature Care Allergy and Congestion ReliefSafeway
Smart Sense Allergy and Congestion ReliefKmart Corporation
Smart Sense Allergy and Congestion Relief DKmart Corporation
Smart Sense Allergy and Congestion Relief Indoor and Outdoor AllergiesKmart Corporation
Smart Sense Allergy and Congestion Relief-DKmart Corporation
Sunmark Loratadine DMc Kesson
Topcare Allergy Relief DTopco Associates LLC
Up and Up Allergy and Congestion ReliefTarget Corporation
Up and Up Allergy Plus Congestion Relief DTarget Corporation
Wal Itin DWalgreen Company
Wal Itin D 12 Hour Allergy and CongestionWalgreen Company
Wal Itin D Non DrowsyWalgreen Company
Wal Itin D Non Drowsy 24 Hour Allergy and CongestionWalgreen Company
SaltsNot Available
Categories
CAS number79794-75-5
WeightAverage: 382.883
Monoisotopic: 382.144805697
Chemical FormulaC22H23ClN2O2
InChI KeyInChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N
InChI
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
IUPAC Name
ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate
SMILES
CCOC(=O)N1CCC(CC1)=C1C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzocycloheptapyridines. These are aromatic compounds containing a benzene ring and a pyridine ring fused to a seven membered carbocycle.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzocycloheptapyridines
Sub ClassNot Available
Direct ParentBenzocycloheptapyridines
Alternative Parents
Substituents
  • Benzocycloheptapyridine
  • Piperidinecarboxylic acid
  • Chlorobenzene
  • Benzenoid
  • Pyridine
  • Piperidine
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Tertiary amine
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationA self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
PharmacodynamicsLoratadine is a long acting second generation antihistamine that is similar in structure to cyproheptadine and azatadine. The pharmacology of loratadine is similar to other antihistamines, but unlike other H1-blockers, loratidine is shown to exhibit competitive, specific, and selective antagonism of H1 receptors. The exact mechanism of this interaction is unknown, but disposition of the drug suggests that loratadine's prolonged antagonism of histamine may be due to the drug's slow dissociation from the receptor or the formation of the active metabolite, desloratadine. Loratadine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.
Mechanism of actionLoratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Loratadine has low affinity for cholinergic receptors and does not exhibit any appreciable alpha-adrenergic blocking activity in-vitro. Loratadine also appears to suppress the release of histamine and leukotrienes from animal mast cells, and the release of leukotrienes from human lung fragments, although the clinical importance of this is unknown.
AbsorptionRapidly absorbed following oral administration (40% bioavailability)
Volume of distributionNot Available
Protein binding97-99%
Metabolism

Hepatic

SubstrateEnzymesProduct
Loratadine
DescarboethoxyloratadineDetails
Route of eliminationNot Available
Half life8.4 hours
ClearanceNot Available
Toxicitysomnolence, tachycardia, and headache LD50=mg/kg (orally in rat)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9754
Caco-2 permeable-0.5488
P-glycoprotein substrateSubstrate0.7337
P-glycoprotein inhibitor IInhibitor0.9505
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterNon-inhibitor0.5143
CYP450 2C9 substrateNon-substrate0.8197
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.677
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9359
Ames testNon AMES toxic0.6884
CarcinogenicityNon-carcinogens0.915
BiodegradationNot ready biodegradable0.9963
Rat acute toxicity2.8964 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7531
hERG inhibition (predictor II)Inhibitor0.8456
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Schering plough healthcare products inc
  • Taro pharmaceuticals usa inc
  • Apotex inc richmond hill
  • L perrigo co
  • Ranbaxy laboratories ltd
  • Silarx pharmaceuticals inc
  • Taro pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Wockhardt eu operations (swiss) ag
  • Wyeth consumer healthcare
  • Impax laboratories inc
  • Watson laboratories inc florida
  • Apotex inc etobicoke site
  • Mylan pharmaceuticals inc
  • Perrigo co
  • Sandoz inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 mg/1
Liquidoral5 mg/5mL
Tabletoral10 mg
Tablet, chewableoral5 mg/5mg
Tablet, chewableoral5 mg/1
Tablet (immediate and extended release)oral
Tablet (extended-release)oral
Syruporal1 mg
Capsule, liquid filledoral10 mg/1
Tablet (orally disintegrating)oral10 mg
Tablet (orally disintegrating)oral5 mg
Tablet, orally disintegratingoral5 mg/1
Tablet, extended releaseoral
Tablet, film coatedoral
Tablet, orally disintegratingoral10 mg/1
Tablet, film coated, extended releaseoral
Capsuleoral10 mg
Tablet, film coatedoral10 mg/1
Solutionoral5 mg/5mL
Prices
Unit descriptionCostUnit
Claritin 30 10 mg tablet Box29.99USD box
Lisinopril 100% powder21.6USD g
Zestril 40 mg tablet2.48USD tablet
Claritin-d 12 hour tablet sa2.46USD tablet
Prinivil 40 mg tablet2.4USD tablet
Zestril 30 mg tablet2.4USD tablet
Zestril 5 mg tablet1.54USD tablet
Lisinopril 30 mg tablet1.51USD tablet
Claritin 10 mg tablet1.48USD tablet
Claritin-d 24 hour tablet sa1.43USD tablet
Zestril 10 mg tablet1.43USD tablet
Claritin 10 mg reditabs1.4USD tablet
Lisinopril 40 mg tablet1.26USD tablet
Zestril 20 mg tablet1.25USD tablet
Prinivil 20 mg tablet1.23USD tablet
Prinivil 10 mg tablet1.15USD tablet
Loratadine-d 24hr tablet1.11USD tablet
Prinivil 5 mg tablet1.11USD tablet
Lisinopril 20 mg tablet1.07USD tablet
Child's claritin 5 mg tablet chew1.02USD tablet
Lisinopril 10 mg tablet0.99USD tablet
Lisinopril 5 mg tablet0.96USD tablet
CVS Pharmacy loratadine-d 24hr tablet0.89USD tablet
Zestril 2.5 mg tablet0.79USD tablet
Tavist nd 10 mg tablet0.74USD tablet
Wal-itin 10 mg tablet0.7USD tablet
Alavert d-12 allergy-sinus tablet0.68USD tablet
Alavert 10 mg tablet0.64USD tablet
Lisinopril 2.5 mg tablet0.64USD tablet
CVS Pharmacy loratadine 10 mg tablet0.52USD tablet
Loratadine 10 mg tablet0.47USD tablet
CVS Pharmacy allergy relief 10 mg tablet0.44USD tablet
Qc loratadine 10 mg tablet0.08USD tablet
Allergy relief 10 mg tablet0.07USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States61327581998-06-012018-06-01
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point134-136 °CPhysProp
water solubility0.000011 mg/mlNot Available
logP5.20SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0134 mg/mLALOGPS
logP4.8ALOGPS
logP4.55ChemAxon
logS-4.5ALOGPS
pKa (Strongest Basic)4.33ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area42.43 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity116.98 m3·mol-1ChemAxon
Polarizability41.67 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Alberto Stampa, Pelayo Camps, Gloria Rodriguez, Jordi Bosch, Maria del Carmen Onrubia, “Process for the preparation of loratadine.” U.S. Patent US6084100, issued July 04, 2000.

US6084100
General References
  1. See S: Desloratadine for allergic rhinitis. Am Fam Physician. 2003 Nov 15;68(10):2015-6. Pubmed
  2. Menardo JL, Horak F, Danzig MR, Czarlewski W: A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. Pubmed
  3. Howarth PH: Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy. 1990 Aug;20 Suppl 2:31-41. Pubmed
  4. Baroody FM, Naclerio RM: Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. Pubmed
External Links
ATC CodesR06AX13
AHFS Codes
  • 04:08.00
  • 24:32.04
PDB EntriesNot Available
FDA labelDownload (232 KB)
MSDSDownload (51.7 KB)
Interactions
Drug Interactions
Drug
AclidiniumAclidinium may increase the anticholinergic activities of Loratadine.
AmiodaroneThe serum concentration of Loratadine can be increased when it is combined with Amiodarone.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Loratadine.
AmphetamineAmphetamine may decrease the sedative activities of Loratadine.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Loratadine.
AzelastineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Loratadine.
Benzylpenicilloyl PolylysineLoratadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Loratadine.
Botulinum Toxin Type ALoratadine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BLoratadine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
BuprenorphineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
CathinoneCathinone may decrease the sedative activities of Loratadine.
Cimetropium BromideLoratadine may increase the anticholinergic activities of Cimetropium Bromide.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
EluxadolineLoratadine may increase the activities of Eluxadoline.
EthanolLoratadine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Loratadine is combined with Glucagon recombinant.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Loratadine.
HydrocodoneLoratadine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Loratadine.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Loratadine.
LumacaftorThe serum concentration of Loratadine can be decreased when it is combined with Lumacaftor.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
MethotrimeprazineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetyrosineLoratadine may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Loratadine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
MirabegronThe risk or severity of adverse effects can be increased when Loratadine is combined with Mirabegron.
MirtazapineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MorphineThe risk or severity of adverse effects can be increased when Loratadine is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
OrphenadrineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
ParaldehydeLoratadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Loratadine is combined with Paroxetine.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
Potassium ChlorideLoratadine may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleLoratadine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Loratadine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Loratadine.
RamosetronLoratadine may increase the activities of Ramosetron.
RanolazineThe serum concentration of Loratadine can be increased when it is combined with Ranolazine.
RopiniroleLoratadine may increase the sedative activities of Ropinirole.
RotigotineLoratadine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Loratadine.
SaquinavirThe serum concentration of Loratadine can be increased when it is combined with Saquinavir.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Loratadine.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Loratadine.
SuvorexantLoratadine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Loratadine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
TesmilifeneThe serum concentration of Loratadine can be decreased when it is combined with Tesmilifene.
ThalidomideLoratadine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
TiotropiumLoratadine may increase the anticholinergic activities of Tiotropium.
TopiramateThe risk or severity of adverse effects can be increased when Loratadine is combined with Topiramate.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Loratadine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Loratadine.
VerapamilThe serum concentration of Loratadine can be increased when it is combined with Verapamil.
ZolpidemLoratadine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Take on empty stomach: 1 hour before or 2 hours after meals.

Targets

1. Histamine H1 receptor

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Histamine H1 receptor P35367 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Cieslewicz G, Gondorowicz K, Grzelewska-Rzymowska I, Rozniecki J, Wojciechowska B: [Effect of loratadine—selective antagonist of histamine (H1) receptor—on allergen-induced bronchoconstriction in atopic asthmatics] Pneumonol Alergol Pol. 1992;60(11-12):11-5. Pubmed
  3. Cieslewicz G, Gondorowicz K, Grzelewska-Rzymowska I, Rozniecki J: [Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction] Pneumonol Alergol Pol. 1995;63(5-6):281-5. Pubmed
  4. Letari O, Miozzo A, Folco G, Belloni PA, Sala A, Rovati GE, Nicosia S: Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity. Eur J Pharmacol. 1994 Feb 15;266(3):219-27. Pubmed
  5. Cavero I, Mestre M, Guillon JM, Heuillet E, Roach AG: Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans? Drug Saf. 1999;21 Suppl 1:19-31; discussion 81-7. Pubmed
  6. Tamura T, Masaki S, Ohmori K, Karasawa A: Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology. 2005 Dec;75(1):45-52. Epub 2005 Jun 7. Pubmed
  7. Grzelewska-Rzymowska I, Gondorowicz K, Cieslewicz G, Rozniecki J, Wojciechowska B: [Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction] Pneumonol Alergol Pol. 1992;60(11-12):16-21. Pubmed
  8. Menardo JL, Horak F, Danzig MR, Czarlewski W: A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. Pubmed
  9. Howarth PH: Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy. 1990 Aug;20 Suppl 2:31-41. Pubmed
  10. Baroody FM, Naclerio RM: Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. Pubmed

Enzymes

1. Cytochrome P450 2C8

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C8 P10632 Details

References:

  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. Pubmed
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

2. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor inducer

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Warzecha H, Ferme D, Peer M, Frank A, Unger M: Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4. J Biosci Bioeng. 2010 Mar;109(3):288-90. Epub 2009 Sep 29. Pubmed
  2. Li C, Lee MY, Choi JS: Effects of silybinin, CYP3A4 and P-glycoprotein inhibitor in vitro, on the bioavailability of loratadine in rats. Pharmazie. 2010 Jul;65(7):510-4. Pubmed
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 2C19

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor inducer

Components

Name UniProt ID Details
Cytochrome P450 2C19 P33261 Details

References:

  1. Barecki ME, Casciano CN, Johnson WW, Clement RP: In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1173-5. Pubmed
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

4. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor inducer

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Barecki ME, Casciano CN, Johnson WW, Clement RP: In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1173-5. Pubmed
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

5. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein. Drug Metab Dispos. 2001 Aug;29(8):1080-3. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:10