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Identification
NameLoratadine
Accession NumberDB00455  (APRD00384)
TypeSmall Molecule
GroupsApproved
Description

Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem]

Structure
Thumb
Synonyms
Claritin
Loratadina
Loratadinum
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Loratadinetablet10 mg/1oralNorthwind Pharmaceuticals, LLC2014-10-27Not applicableUs
Loratadine Allergy Relieftablet10 mg/1oralClinical Solutions Wholesale2003-08-28Not applicableUs
Loratadine Antihistaminetablet10 mg/1oralbryant ranch prepack2008-10-15Not applicableUs
Loratadineantihistamine Antihistaminetablet10 mg/1oralREMEDYREPACK INC.2013-05-20Not applicableUs
Loratadineantihistamine Antihistaminetablet10 mg/1oralREMEDYREPACK INC.2014-02-06Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
24 Hour Allergy Relieftablet10 mg/1oralMeijer Distribution Inc2014-12-30Not applicableUs
24 Hour Allergy Remedytablet10 mgoralVita Health Products Inc2006-07-28Not applicableCanada
7 Select Allergy Relieftablet10 mg/1oral7 Eleven2014-05-14Not applicableUs
Alavert Allergytablet, orally disintegrating10 mg/1oralPfizer Consumer Healthcare2002-12-19Not applicableUs
Alavert Allergytablet, orally disintegrating10 mg/1oralPfizer Consumer Healthcare2002-12-19Not applicableUs
Allegy Relief 24 Hour Non Drowsytablet10 mg/1oralHannaford Brothers Company2006-09-07Not applicableUs
Allergytablet10 mg/1oralMajor Pharmaceuticals2005-02-21Not applicableUs
Allergy Relieftablet, orally disintegrating10 mg/1oralCardinal Health2007-08-31Not applicableUs
Allergy Reliefsolution5 mg/5mLoralMedicine Shoppe International Inc2004-08-20Not applicableUs
Allergy Relieftablet10 mg/1oralNovartis Consumer Health, Inc.2010-01-04Not applicableUs
Allergy Reliefsolution5 mg/5mLoralKroger Company2004-08-20Not applicableUs
Allergy Relieftablet10 mg/1oralGeri Care Pharmaceutical Corp2008-01-01Not applicableUs
Allergy Relieftablet10 mg/1oralAllegiant Health2014-12-16Not applicableUs
Allergy Relieftablet10 mg/1oralMeijer Distribution Inc2007-04-18Not applicableUs
Allergy Relieftablet10 mg/1oralSafeway2013-07-29Not applicableUs
Allergy Relieftablet, orally disintegrating10 mg/1oralOhm Laboratories Inc.2007-08-31Not applicableUs
Allergy Relieftablet10 mg/1oralNovartsi Consumer Health, Inc.2010-01-11Not applicableUs
Allergy Relieftablet10 mg/1oralCVS Pharmacy2005-01-04Not applicableUs
Allergy Relieftablet10 mg/1oralRite Aid Corporation2004-10-21Not applicableUs
Allergy Relieftablet10 mg/1oralHy Vee Inc2005-05-23Not applicableUs
Allergy Relieftablet10 mg/1oralKroger Company2005-08-22Not applicableUs
Allergy Relieftablet10 mg/1oralShopko Stores Operating Co., LLC2013-09-12Not applicableUs
Allergy Relief 24 Hourtablet10 mg/1oralWestern Family Foods Inc2005-04-04Not applicableUs
Allergy Relief Childrenssolution5 mg/5mLoralH E B2010-02-27Not applicableUs
Allergy Relief Childrenssolution5 mg/5mLoralH E B2004-08-20Not applicableUs
Allergy Relief Medicationtablet10 mg/1oralTarget Brands, Inc.2010-01-31Not applicableUs
Allergy Relief Non Drowsytablet10 mg/1oralSelect Corporation2012-10-15Not applicableUs
Allergy Remedytablet10 mgoralApotex Inc2013-05-23Not applicableCanada
Allertincapsule10 mgoralApotex Inc2013-10-31Not applicableCanada
Allertintablet10 mgoralApotex IncNot applicableNot applicableCanada
Allertin Tablets 10mgtablet10 mgoralVita Health Products Inc2002-01-012008-08-05Canada
Apo-loratadinetablet10 mgoralApotex Inc2001-06-27Not applicableCanada
Bactimicina Allergytablet10 mg/1oralDLC Laboratories, Inc.2009-10-21Not applicableUs
Being Well Allergy Relieftablet10 mg/1oralSave A Lot Food Stores Ltd2006-02-25Not applicableUs
Berkley and Jensen Allergy Relieftablet10 mg/1oralBJWC2009-04-17Not applicableUs
Berkley and Jensen Loratadine Non Drowsytablet10 mg/1oralBJWC2009-04-17Not applicableUs
Best Choice Childrens Loratadinesolution5 mg/5mLoralValu Merchandisers Company2004-08-20Not applicableUs
Best Choice Childrens Loratadine Sugar Freesolution5 mg/5mLoralValu Merchandisers Company2010-02-27Not applicableUs
Care One Childrens Loratadinesolution5 mg/5mLoralAmerican Sales Company2010-02-27Not applicableUs
Careone Allergy Relief 24 Hourtablet10 mg/1oralAmerican Sales Company2006-06-02Not applicableUs
Children Claritin Allergysolution5 mg/5mLoralBayer Health Care Consumer Care2015-05-26Not applicableUs
Childrens 24 Hour Allergysolution5 mg/5mLoralMeijer Distribution Inc2004-08-20Not applicableUs
Childrens Allergyliquid5 mg/5mLoralDolgencorp, Inc. (Dollar General & Rexall)2016-02-29Not applicableUs
Childrens Allergysolution5 mg/5mLoralPublix Super Markets Inc2010-02-27Not applicableUs
Childrens Allergy Dye Freeliquid5 mg/5mLoralQUALITY CHOICE (Chain Drug Marketing Association)2015-01-31Not applicableUs
Childrens Allergy Dye Freeliquid5 mg/5mLoralTarget Corporation2014-10-31Not applicableUs
Childrens Allergy Reliefsolution5 mg/5mLoralCVS Pharmacy2004-08-20Not applicableUs
Childrens Allergy Reliefsolution5 mg/5mLoralRite Aid Corporation2010-02-27Not applicableUs
Childrens Allergy Reliefsolution5 mg/5mLoralSupervalu Inc2004-08-20Not applicableUs
Childrens Allergy Reliefsolution5 mg/5mLoralWal Mart Stores Inc2004-08-20Not applicableUs
Childrens Allergy Reliefsolution5 mg/5mLoralRite Aid Corporation2004-08-20Not applicableUs
Childrens Allergy Reliefsolution5 mg/5mLoralCVS Pharmacy2010-02-27Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralTaro Pharmaceuticals U.S.A., Inc.2010-02-27Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralAmerican Sales Company2004-08-20Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralTaro Pharmaceuticals U.S.A., Inc.2004-08-20Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralTaro Pharmaceuticals U.S.A., Inc.2004-08-20Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralRite Aid Corporation2004-08-20Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralTarget Corporation2010-02-27Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralAidarex Pharmaceuticals LLC2004-08-20Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralKinray, Inc.2004-08-20Not applicableUs
Childrens Loratadinesolution5 mg/5mLoralTarget Corporation2004-08-20Not applicableUs
Childrens Non-drowsy 24-hour Allergy Reliefsolution5 mg/5mLoralSafeway Inc.2004-08-20Not applicableUs
Childrens Non-drowsy 24-hour Allergy Reliefsolution5 mg/5mLoralSafeway Inc.2010-02-27Not applicableUs
Childrens Non-drowsy Allergy Relief 24-hoursolution5 mg/5mLoralKroger Company2010-02-27Not applicableUs
Childrens Wal-itinsolution5 mg/5mLoralWalgreen Company2010-02-27Not applicableUs
Claritintablet, chewable5 mg/5mgoralBayer Health Care Llc2015-09-25Not applicableUs
Claritintablet, chewable5 mg/1oralMSD Consumer Care, Inc.2009-03-05Not applicableUs
Claritintablet, chewable5 mg/1oralMSD Consumer Care, Inc.2006-08-23Not applicableUs
Claritinsolution5 mg/5mLoralBayer Health Care Llc2011-03-01Not applicableUs
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs
Claritintablet10 mgoralBayer Inc Consumer Care1988-12-18Not applicableCanada
Claritintablet10 mg/1oralMSD Consumer Care, Inc.1993-04-12Not applicableUs
Claritin Antihistaminetablet10 mg/1oralLil' Drug Store Products, Inc2004-11-23Not applicableUs
Claritin Kidssyrup1 mgoralBayer Inc Consumer Care2000-04-06Not applicableCanada
Claritin Liqui-gelscapsule, liquid filled10 mg/1oralMSD Consumer Care, Inc.2008-06-16Not applicableUs
Claritin Liquid Capsulescapsule10 mgoralBayer Inc Consumer Care2013-07-01Not applicableCanada
Claritin Rapid Dissolvetablet (orally disintegrating)5 mgoralBayer Inc Consumer CareNot applicableNot applicableCanada
Claritin Rapid Dissolvetablet (orally disintegrating)10 mgoralBayer Inc Consumer Care1998-05-05Not applicableCanada
Claritin Reditabstablet, orally disintegrating10 mg/1oralMSD Consumer Care, Inc.2002-11-27Not applicableUs
Claritin Reditabstablet, orally disintegrating10 mg/1oralMSD Consumer Care, Inc.2002-11-27Not applicableUs
Claritin Reditabstablet, orally disintegrating5 mg/1oralMSD Consumer Care, Inc.2006-12-12Not applicableUs
Claritin Syrup 1mg/mlsyrup1 mgoralSchering Plough Canada Inc1993-12-312012-07-24Canada
Cleartimetablet10 mg/1oralWestern Family Foods Inc2015-03-04Not applicableUs
Cleartimetablet10 mg/1oralHy Vee Inc2015-02-16Not applicableUs
Counteract Allergytablet10 mg/1oralMelaleuca, Inc.2008-06-28Not applicableUs
Dg Health Allergy Relieftablet10 mg/1oralDolgencorp, LLC2012-04-13Not applicableUs
Equaline Allergy Relieftablet10 mg/1oralSupervalu Inc2005-02-07Not applicableUs
Equaline Allergy Relief Non Drowsytablet, orally disintegrating10 mg/1oralSupervalu Inc2004-08-05Not applicableUs
Equaline Childrens Loratadinesolution5 mg/5mLoralSupervalu Inc2010-02-27Not applicableUs
Equate Allergy Relieftablet10 mg/1oralWal Mart Stores Inc2007-04-27Not applicableUs
Equate Childrens Allergy Reliefsolution5 mg/5mLoralWal Mart Stores Inc2010-02-27Not applicableUs
Exchange Select Allergy Relieftablet10 mg/1oralArmy & Air Force Exchange Service2008-08-26Not applicableUs
Fad First Aid Direct Allergy Relieftablet10 mg/1oralFirst Aid Direct2012-12-19Not applicableUs
Family Dollar Allergy Relieftablet10 mg/1oralNovartis Consumer Health, Inc.2004-09-30Not applicableUs
Formucare Allergy Relieftablet10 mg/1oralAccess Business Group LLC2005-01-27Not applicableUs
Good Neighbor Pharmacy Allergy Relieftablet, orally disintegrating10 mg/1oralAmerisource Bergen2004-03-15Not applicableUs
Good Neighbor Pharmacy Childrens Loratadinesolution5 mg/5mLoralAmerisource Bergen2010-02-27Not applicableUs
Good Neighbor Pharmacy Childrens Loratadinesolution5 mg/5mLoralAmerisource Bergen2004-08-20Not applicableUs
Good Neighbor Pharmacy Childrens Loratadinesolution5 mg/5mLoralAmerisource Bergen2004-08-20Not applicableUs
Good Neighbor Pharmacy Cleartimetablet10 mg/1oralAmerisource Bergen2015-03-25Not applicableUs
Good Neighbor Pharmacy Loratadinetablet10 mg/1oralAmerisource Bergen2008-11-10Not applicableUs
Good Sense Allergy Relieftablet10 mg/1oralL. Perrigo Company2004-09-21Not applicableUs
Good Sense Childrens Loratadinesolution5 mg/5mLoralGeiss, Destin & Dunn, Inc.2010-02-27Not applicableUs
Harmon Face Values Allergy Relieftablet10 mg/1oralHarmon Stores Inc.2011-12-18Not applicableUs
Harris Teeter Allergy Relieftablet10 mg/1oralHarris Teeter, LLC2015-06-24Not applicableUs
Health Mart Allergy Relieftablet10 mg/1oralMc Kesson2012-01-13Not applicableUs
Health Mart Loratadinetablet10 mg/1oralMc Kesson2014-10-02Not applicableUs
Health Mart Pharmacy Childrens Loratadinesolution5 mg/5mLoralHealth Mart2004-08-20Not applicableUs
Healthmart Childrens Loratadinesolution5 mg/5mLoralMc Kesson2010-02-27Not applicableUs
Healthmart Loratadine ODTtablet, orally disintegrating10 mg/1oralHealth Mart2007-08-31Not applicableUs
Healthy Accents Allergy Relieftablet10 mg/1oralDZA Brands LLC2007-12-15Not applicableUs
Hy-vee Childrens Loratadinesolution5 mg/5mLoralHyVee Inc2010-02-27Not applicableUs
Kirkland Signature Allercleartablet10 mg/1oralCostco Wholesale Company2007-05-22Not applicableUs
Leader Allergy Relieftablet10 mg/1oralCardinal Health2014-07-02Not applicableUs
Leader Allergy Relieftablet, orally disintegrating10 mg/1oralCardinal Health2004-02-25Not applicableUs
Leader Allergy Relieftablet, orally disintegrating10 mg/1oralCardinal Health2004-02-25Not applicableUs
Leader Childrens Allergy Reliefsolution5 mg/5mLoralCardinal Health2004-08-20Not applicableUs
Leader Loratadinetablet10 mg/1oralCardinal Health2003-08-19Not applicableUs
Live Better Loratadinesolution5 mg/5mLoralThe Great Atlantic & Pacific Tea Company2010-02-27Not applicableUs
Loratadinetablet10 mg/1oralCardinal Health2011-06-03Not applicableUs
Loratadinetablet10 mg/1oralInnovative Manufacturing and Distribution Services, Inc.2008-12-01Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralTarget Corporation2007-08-31Not applicableUs
Loratadinesolution5 mg/5mLoralRebel Distributors Corp2004-08-20Not applicableUs
Loratadinetablet10 mg/1oralMylan Pharmaceuticals Inc.2013-03-27Not applicableUs
Loratadinetablet10 mg/1oralCardinal Health2003-01-212015-12-29Us
Loratadinetablet10 mg/1oralDLC Laboratories, Inc2009-06-06Not applicableUs
Loratadinetablet10 mg/1oralMylan Institutional Inc.2013-04-30Not applicableUs
Loratadinesolution5 mg/5mLoralSilarx Pharmaceuticals, Inc2010-11-24Not applicableUs
Loratadinetablet10 mg/1oralFamily Dollar Services, Inc.2003-08-19Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralChain Drug Marketing Association Inc.2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralSelect Brand2003-08-19Not applicableUs
Loratadinesolution5 mg/5mLoralMajor Pharmaceuticals, Inc2011-02-17Not applicableUs
Loratadinetablet10 mg/1oralKAISER FOUNDATION HOSPITALS2011-02-23Not applicableUs
Loratadinetablet10 mg/1oralCardinal Health2005-01-24Not applicableUs
Loratadinetablet10 mg/1oralShopko Stores Operating Co., LLC2003-08-19Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralSUPERVALU INC.2013-12-03Not applicableUs
Loratadinetablet10 mg/1oralKinray2003-08-19Not applicableUs
Loratadinetablet10 mgoralApotex Inc2013-04-18Not applicableCanada
Loratadinetablet10 mg/1oralAv Pak2016-03-11Not applicableUs
Loratadinetablet10 mg/1oralMajor Pharmaceuticals2003-08-28Not applicableUs
Loratadinetablet10 mg/1oralAmerisource Bergen2003-08-19Not applicableUs
Loratadinetablet10 mg/1oralCardinal Health2009-11-19Not applicableUs
Loratadinetablet10 mg/1oralPublix Super Markets Inc2003-08-19Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralValu Merchandisers Company2007-08-31Not applicableUs
Loratadinesolution5 mg/5mLoralPreferred Pharmaceuticals, Inc.2012-05-09Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralGood Neighbor Pharmacy2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralSUPERVALU INC.2003-08-19Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralAmerican Sales Company2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Loratadinetablet10 mg/1oralApotex Corp.2005-01-24Not applicableUs
Loratadinetablet10 mg/1oralChain Drug Marketing Association Inc.2003-08-19Not applicableUs
Loratadinetablet10 mg/1oralPremier Value2003-08-19Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralGood Neighbor Pharmacy2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralValu Merchandisers Company2003-08-19Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralAmerican Sales Company2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralMedline Industries, Inc.2003-08-19Not applicableUs
Loratadinetablet10 mg/1oralFred's Inc.2003-08-19Not applicableUs
Loratadinetablet10 mg/1oralNorthstar Rx LLC2016-02-01Not applicableUs
Loratadinesolution5 mg/5mLoralCardinal Health2004-08-20Not applicableUs
Loratadinesolution5 mg/5mLoralPhysicians Total Care, Inc.2006-04-28Not applicableUs
Loratadinetablet10 mg/1oralAmerican Health Packaging2008-01-08Not applicableUs
Loratadinetablet10 mg/1oralSafeway Inc.2009-06-06Not applicableUs
Loratadinetablet10 mg/1oralBlenheim Pharmacal, Inc.2014-02-09Not applicableUs
Loratadinetablet10 mg/1oralNovartis Consumer Health, Inc.2004-09-30Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralAmerican Sales Company2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralCVS Pharmacy2010-01-08Not applicableUs
Loratadinetablet10 mg/1oralSandoz Inc2003-01-21Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralWalgreen Company2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralOhm Laboratories Inc.2009-06-23Not applicableUs
Loratadinetablet10 mg/1oralPhysicians Total Care, Inc.2005-04-18Not applicableUs
Loratadinetablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Loratadinetablet10 mg/1oralCardinal Health2013-04-30Not applicableUs
Loratadinetablet10 mg/1oralMc Kesson Contract Packaging2011-09-26Not applicableUs
Loratadinetablet10 mgoralMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Loratadinetablet, orally disintegrating10 mg/1oralTarget Corporation2007-08-31Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralTopcare Associates LLC2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralNovartis Consumer Health, Inc.2004-09-30Not applicableUs
Loratadinetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-02-23Not applicableUs
Loratadinetablet10 mg/1oralH.J. Harkins Company, Inc.2008-10-15Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralGood Neighbor Pharmacy2007-08-31Not applicableUs
Loratadinetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-01-21Not applicableUs
Loratadinetablet10 mg/1oralWalgreen Company2013-12-05Not applicableUs
Loratadinesolution5 mg/5mLoralSilarx Pharmaceuticals, Inc2010-11-24Not applicableUs
Loratadinetablet, orally disintegrating10 mg/1oralSelect Brand2007-08-31Not applicableUs
Loratadine Allergy Relieftablet10 mg/1oralWin Co Foods, Llc2003-08-28Not applicableUs
Loratadine Allergy Relieftablet10 mg/1oralOhm Laboratories Inc.2003-08-28Not applicableUs
Loratadine Allergy Relieftablet10 mg/1oralProficient Rx LP2003-08-28Not applicableUs
Loratadine Allergy Relieftablet10 mg/1oralWin Co Foods, Llc2003-08-28Not applicableUs
Loratadine Antihistaminetablet10 mg/1oralProficient Rx LP2008-10-15Not applicableUs
Loratadine Antihistaminetablet10 mg/1oralCardinal Health2008-10-15Not applicableUs
Loratadine Antihistaminetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2008-10-15Not applicableUs
Loratadine Antihistaminetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-10-15Not applicableUs
Loratadine Antihistaminetablet10 mg/1oralUnit Dose Services2008-10-15Not applicableUs
Loratadine Antihistaminetablet10 mg/1oralPerrigo New York Inc2008-10-15Not applicableUs
Loratadine Antihistaminetablet10 mg/1oralUnit Dose Services2008-10-15Not applicableUs
Loratadine ODtablet, orally disintegrating10 mg/1oralFred's Inc.2007-08-31Not applicableUs
Loratadine ODTtablet, orally disintegrating10 mg/1oralTopco Associates LLC2007-08-31Not applicableUs
Loratadine ODTtablet, orally disintegrating10 mg/1oralShopko Stores Operating Co., LLC2007-08-31Not applicableUs
Loratadine ODTtablet, orally disintegrating10 mg/1oralChain Drug Consortium, LLC2007-08-31Not applicableUs
Loratadine ODTtablet, orally disintegrating10 mg/1oralMajor Pharmaceuticals2007-08-31Not applicableUs
Loratadine ODTtablet, orally disintegrating10 mg/1oralMeijer Distribution, Inc.2007-08-31Not applicableUs
Loratadine ODTtablet, orally disintegrating10 mg/1oralSafeway Inc.2007-08-31Not applicableUs
Loratadine ODTtablet, orally disintegrating10 mg/1oralMeijer Distribution, Inc.2007-08-31Not applicableUs
Loratadine ODTtablet, orally disintegrating10 mg/1oralCVS Pharmacy2007-09-27Not applicableUs
Loratadine Soft Gel Capsulecapsule10 mgoralApotex Inc2012-09-07Not applicableCanada
Loratadine Tablets 10mgtablet10 mgoralVita Health Products Inc2002-01-012008-08-05Canada
Loratadineantihistamine Antihistaminetablet10 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Medicine Shoppe Loratadine Allergy Relieftablet10 mg/1oralThe Medicine Shoppe International2003-08-19Not applicableUs
Medique Loradamedtablet, film coated10 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Meijer Childrens 24 Hour Allergysolution5 mg/5mLoralMeijer Distribution Inc2010-02-27Not applicableUs
Members Mark Loratadinetablet10 mg/1oralSam's West Inc2007-05-21Not applicableUs
Moore Medical Loratadinetablet, film coated10 mg/1oralMoore Medical LLC2008-12-30Not applicableUs
Novo-loratadinetablet10 mgoralNovopharm LimitedNot applicableNot applicableCanada
Preferred Plus (kinray) Childrens Loratadinesolution5 mg/5mLoralPreferred Plus (Kinray)2010-02-27Not applicableUs
Preferred Plus Allergy Relieftablet10 mg/1oralKinray2014-09-22Not applicableUs
Premier Value Childrens Loratadinesolution5 mg/5mLoralChain Drug Constortium2010-02-27Not applicableUs
Premier Value Childrens Loratadinesolution5 mg/5mLoralChain Drug Constortium2004-08-20Not applicableUs
Quality Choice Childrens Allergy Reliefsolution5 mg/5mLoralChain Drug Marketing Association2004-08-20Not applicableUs
Quality Choice Childrens Allergy Reliefsolution5 mg/5mLoralChain Drug Marketing Association, Inc.2010-02-27Not applicableUs
Rexall Allergy Relief Non Drowsytablet10 mg/1oralDolgencorp, LLC2010-08-22Not applicableUs
Shoprite Allergy Relieftablet10 mg/1oralWakefern Food Corporation2013-08-06Not applicableUs
Signature Care Allergy Relieftablet10 mg/1oralSafeway2016-02-08Not applicableUs
Simply Right Loratadinetablet10 mg/1oralSam's West Inc2014-01-03Not applicableUs
Smart Sense Allergy Relief Non Drowsytablet10 mg/1oralKmart Corporation2010-11-24Not applicableUs
Sound Body Allergy Relieftablet10 mg/1oralBig Lots Stores, Inc.2015-06-12Not applicableUs
Sunmark Allergy Relieftablet, orally disintegrating10 mg/1oralMc Kesson2004-02-02Not applicableUs
Sunmark Childrens Loratadinesolution5 mg/5mLoralMc Kesson2004-08-20Not applicableUs
Sunmark Childrens Loratadinesolution5 mg/5mLoralMc Kesson2010-02-27Not applicableUs
Sunmark Childrens Loratadinesolution5 mg/5mLoralMc Kesson2004-08-20Not applicableUs
Sunmark Loratadinetablet10 mg/1oralMc Kesson2007-06-21Not applicableUs
Sunmark Loratadine Allergy Relieftablet, orally disintegrating10 mg/1oralMc Kesson2004-02-02Not applicableUs
Sunmark Loratadine ODTtablet, orally disintegrating10 mg/1oralSunmark2007-08-31Not applicableUs
Sunmark Loratadine ODTtablet, orally disintegrating10 mg/1oralSunmark2007-08-31Not applicableUs
Taro-loratadinetablet10 mgoralTaro Pharmaceuticals IncNot applicableNot applicableCanada
Topcare Allergy Relieftablet, orally disintegrating10 mg/1oralTopco Associates LLC2004-02-03Not applicableUs
Topcare Allergy Relieftablet, orally disintegrating10 mg/1oralTopco Associates LLC2004-03-09Not applicableUs
Topcare Allergy Relief 24 Hourtablet10 mg/1oralTopco Associates LLC2005-01-25Not applicableUs
Topcare Childrens Allergy Relief 24 Hour Non Drowsytablet, orally disintegrating10 mg/1oralTopco Associates LLC2005-03-02Not applicableUs
Topcare Childrens Loratadinesolution5 mg/5mLoralTopco Associates LLC2010-02-27Not applicableUs
Topcare Clear Timetablet10 mg/1oralTopco Associates LLC2015-01-13Not applicableUs
Up and Up Allergy Relieftablet10 mg/1oralTarget Corporation2012-03-26Not applicableUs
Up and Up Allergy Relieftablet, orally disintegrating10 mg/1oralTarget Corporation2009-06-16Not applicableUs
Vicks Qlearquil All Day and All Night 24 Hour Allergy Relieftablet10 mg/1oralThe Procter & Gamble Manufacturing Company2014-03-01Not applicableUs
Wal Itintablet10 mg/1oralWalgreen Company2009-02-13Not applicableUs
Wal Itintablet10 mg/1oralWalgreen Company2009-02-13Not applicableUs
Wal-itin Allergy Reliefsolution5 mg/5mLoralWalgreen Company2004-08-20Not applicableUs
Welby Health Allergy Relieftablet10 mg/1oralAldi, Inc2007-04-12Not applicableUs
Western Family Childrens Allergy Reliefsolution5 mg/5mLoralWestern Family Foods Inc2010-02-27Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Help I Have Allergiestablet10 mg/1oralHelp Remedies, Inc.2009-07-01Not applicableUs
Loratadinetablet10 mg/1oralRebel Distributors Corp2010-01-21Not applicableUs
Loratadinetablet10 mg/1oralCardinal Health2013-06-14Not applicableUs
International Brands
NameCompany
AerotinaNot Available
AlavertNot Available
BiloinaNot Available
CiveranNot Available
FristaminNot Available
HistaloranNot Available
LomilanNot Available
LoracertNot Available
LoradexNot Available
LoranoxNot Available
LorastineNot Available
LoratyneNot Available
LoritineNot Available
NularefNot Available
RestamineNot Available
RoletraNot Available
SensibitNot Available
Brand mixtures
NameLabellerIngredients
Alavert Allergy Sinus D-12Wyeth Consumer Healthcare
Allerclear-D 24 HourCostco Wholesale Corporation
Allergy and Congestion ReliefL. Perrigo Company
Allergy and Congestion Relief Non DrowsyAmerisource Bergen
Allergy Relief DShopko Stores Operating Co., LLC
Allergy Relief D 12CVS Pharmacy
Allergy Relief D 12 HourPublix Super Markets Inc
Allergy Relief D 24 HourPublix Super Markets Inc
Allergy Relief-DCVS Pharmacy
Allergy Relief-D 24 HourShopko Stores Operating Co., LLC
Allergy Relief-d24 Hour 24 HourTopco Associates LLC
Careone Allergy and Congestion ReliefAmerican Sales Company
Chlor-tripolon Nd SrtSchering Plough Canada Inc
Claritin Allergy + SinusBayer Inc Consumer Care
Claritin Allergy + Sinus Extra StrengthBayer Inc Consumer Care
Claritin-D 12 HourMSD Consumer Care, Inc.
Claritin-D 24 HourMSD Consumer Care, Inc.
Equaline Allergy and Congestion ReliefSupervalu Inc
Good Neighbor Pharmacy Loratadine DAmerisource Bergen
Good Neighbor Pharmacy Loratadine D 24 HourAmerisource Bergen
Good Sense Allergy and Congestion ReliefL Perrigo Company
Good Sense Allergy and Congestion Relief Non Drowsy 24 HourL Perrigo Company
Health Mart Allergy and CongestionMc Kesson
Healthy Accents Allergy and Congestion Relief 24 Hour Non DrowsyDZA Brands LLC
Kirkland Signature Allerclear D 12 HrCostco Wholesale Company
Kirkland Signature Allerclear D 24hrCostco Wholesale Company
Leader Allergy Relief D-24Cardinal Health
LiberatorSchering Plough Canada Inc
Loratadine and PseudoephedrineWalgreen Company
Loratadine and Pseudoephedrine SulfateMajor Pharmaceuticals
Loratadine DPerrigo New York Inc
Loratadine D 24 HourPerrigo New York Inc
Medicine Shoppe Allergy Relief D24The Medicine Shoppe International
Preferred Plus Allergy and Congestion ReliefKinray
Shoprite Allergy and Congestion ReliefWakefern Food Corporation
Signature Care Allergy and Congestion ReliefSafeway
Smart Sense Allergy and Congestion ReliefKmart Corporation
Smart Sense Allergy and Congestion Relief DKmart Corporation
Smart Sense Allergy and Congestion Relief Indoor and Outdoor AllergiesKmart Corporation
Smart Sense Allergy and Congestion Relief-DKmart Corporation
Sunmark Loratadine DMc Kesson
Topcare Allergy Relief DTopco Associates LLC
Up and Up Allergy and Congestion ReliefTarget Corporation
Up and Up Allergy Plus Congestion Relief DTarget Corporation
Wal Itin DWalgreen Company
Wal Itin D 12 Hour Allergy and CongestionWalgreen Company
Wal Itin D Non DrowsyWalgreen Company
Wal Itin D Non Drowsy 24 Hour Allergy and CongestionWalgreen Company
Wal-itin D 24 HourWalgreen Company
SaltsNot Available
Categories
UNII7AJO3BO7QN
CAS number79794-75-5
WeightAverage: 382.883
Monoisotopic: 382.144805697
Chemical FormulaC22H23ClN2O2
InChI KeyInChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N
InChI
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
IUPAC Name
ethyl 4-{13-chloro-4-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidine-1-carboxylate
SMILES
CCOC(=O)N1CCC(CC1)=C1C2=C(CCC3=C1N=CC=C3)C=C(Cl)C=C2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzocycloheptapyridines. These are aromatic compounds containing a benzene ring and a pyridine ring fused to a seven membered carbocycle.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzocycloheptapyridines
Sub ClassNot Available
Direct ParentBenzocycloheptapyridines
Alternative Parents
Substituents
  • Benzocycloheptapyridine
  • Piperidinecarboxylic acid
  • Chlorobenzene
  • Benzenoid
  • Pyridine
  • Piperidine
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Tertiary amine
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationA self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
PharmacodynamicsLoratadine is a long acting second generation antihistamine that is similar in structure to cyproheptadine and azatadine. The pharmacology of loratadine is similar to other antihistamines, but unlike other H1-blockers, loratidine is shown to exhibit competitive, specific, and selective antagonism of H1 receptors. The exact mechanism of this interaction is unknown, but disposition of the drug suggests that loratadine's prolonged antagonism of histamine may be due to the drug's slow dissociation from the receptor or the formation of the active metabolite, desloratadine. Loratadine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.
Mechanism of actionLoratadine competes with free histamine and exhibits specific, selective peripheral H1 antagonistic activity. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Loratadine has low affinity for cholinergic receptors and does not exhibit any appreciable alpha-adrenergic blocking activity in-vitro. Loratadine also appears to suppress the release of histamine and leukotrienes from animal mast cells, and the release of leukotrienes from human lung fragments, although the clinical importance of this is unknown.
Related Articles
AbsorptionRapidly absorbed following oral administration (40% bioavailability)
Volume of distributionNot Available
Protein binding97-99%
Metabolism

Hepatic

SubstrateEnzymesProduct
Loratadine
DescarboethoxyloratadineDetails
Route of eliminationNot Available
Half life8.4 hours
ClearanceNot Available
Toxicitysomnolence, tachycardia, and headache LD50=mg/kg (orally in rat)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9754
Caco-2 permeable-0.5488
P-glycoprotein substrateSubstrate0.7337
P-glycoprotein inhibitor IInhibitor0.9505
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterNon-inhibitor0.5143
CYP450 2C9 substrateNon-substrate0.8197
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.677
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9359
Ames testNon AMES toxic0.6884
CarcinogenicityNon-carcinogens0.915
BiodegradationNot ready biodegradable0.9963
Rat acute toxicity2.8964 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7531
hERG inhibition (predictor II)Inhibitor0.8456
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Schering plough healthcare products inc
  • Taro pharmaceuticals usa inc
  • Apotex inc richmond hill
  • L perrigo co
  • Ranbaxy laboratories ltd
  • Silarx pharmaceuticals inc
  • Taro pharmaceutical industries ltd
  • Teva pharmaceuticals usa inc
  • Wockhardt eu operations (swiss) ag
  • Wyeth consumer healthcare
  • Impax laboratories inc
  • Watson laboratories inc florida
  • Apotex inc etobicoke site
  • Mylan pharmaceuticals inc
  • Perrigo co
  • Sandoz inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 mg/1
Liquidoral5 mg/5mL
Tabletoral10 mg
Tablet, chewableoral5 mg/5mg
Tablet, chewableoral5 mg/1
Tablet (immediate and extended release)oral
Tablet (extended-release)oral
Capsule, liquid filledoral10 mg/1
Tablet (orally disintegrating)oral10 mg
Tablet (orally disintegrating)oral5 mg
Tablet, orally disintegratingoral5 mg/1
Syruporal1 mg
Tablet, extended releaseoral
Tablet, film coatedoral
Tablet, orally disintegratingoral10 mg/1
Tablet, film coated, extended releaseoral
Capsuleoral10 mg
Tablet, film coatedoral10 mg/1
Solutionoral5 mg/5mL
Prices
Unit descriptionCostUnit
Claritin 30 10 mg tablet Box29.99USD box
Lisinopril 100% powder21.6USD g
Zestril 40 mg tablet2.48USD tablet
Claritin-d 12 hour tablet sa2.46USD tablet
Prinivil 40 mg tablet2.4USD tablet
Zestril 30 mg tablet2.4USD tablet
Zestril 5 mg tablet1.54USD tablet
Lisinopril 30 mg tablet1.51USD tablet
Claritin 10 mg tablet1.48USD tablet
Claritin-d 24 hour tablet sa1.43USD tablet
Zestril 10 mg tablet1.43USD tablet
Claritin 10 mg reditabs1.4USD tablet
Lisinopril 40 mg tablet1.26USD tablet
Zestril 20 mg tablet1.25USD tablet
Prinivil 20 mg tablet1.23USD tablet
Prinivil 10 mg tablet1.15USD tablet
Loratadine-d 24hr tablet1.11USD tablet
Prinivil 5 mg tablet1.11USD tablet
Lisinopril 20 mg tablet1.07USD tablet
Child's claritin 5 mg tablet chew1.02USD tablet
Lisinopril 10 mg tablet0.99USD tablet
Lisinopril 5 mg tablet0.96USD tablet
CVS Pharmacy loratadine-d 24hr tablet0.89USD tablet
Zestril 2.5 mg tablet0.79USD tablet
Tavist nd 10 mg tablet0.74USD tablet
Wal-itin 10 mg tablet0.7USD tablet
Alavert d-12 allergy-sinus tablet0.68USD tablet
Alavert 10 mg tablet0.64USD tablet
Lisinopril 2.5 mg tablet0.64USD tablet
CVS Pharmacy loratadine 10 mg tablet0.52USD tablet
Loratadine 10 mg tablet0.47USD tablet
CVS Pharmacy allergy relief 10 mg tablet0.44USD tablet
Qc loratadine 10 mg tablet0.08USD tablet
Allergy relief 10 mg tablet0.07USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6132758 No1998-06-012018-06-01Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point134-136 °CPhysProp
water solubility0.000011 mg/mlNot Available
logP5.20SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0134 mg/mLALOGPS
logP4.8ALOGPS
logP4.55ChemAxon
logS-4.5ALOGPS
pKa (Strongest Basic)4.33ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area42.43 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity116.98 m3·mol-1ChemAxon
Polarizability41.67 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Alberto Stampa, Pelayo Camps, Gloria Rodriguez, Jordi Bosch, Maria del Carmen Onrubia, “Process for the preparation of loratadine.” U.S. Patent US6084100, issued July 04, 2000.

US6084100
General References
  1. See S: Desloratadine for allergic rhinitis. Am Fam Physician. 2003 Nov 15;68(10):2015-6. [PubMed:14655812 ]
  2. Menardo JL, Horak F, Danzig MR, Czarlewski W: A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. [PubMed:9444440 ]
  3. Howarth PH: Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy. 1990 Aug;20 Suppl 2:31-41. [PubMed:1977506 ]
  4. Baroody FM, Naclerio RM: Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. [PubMed:11291777 ]
External Links
ATC CodesR06AX13
AHFS Codes
  • 04:08.00
  • 24:32.04
PDB EntriesNot Available
FDA labelDownload (232 KB)
MSDSDownload (51.7 KB)
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may decrease the sedative activities of Loratadine.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may decrease the sedative activities of Loratadine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Loratadine.
AbirateroneThe serum concentration of Loratadine can be increased when it is combined with Abiraterone.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Loratadine.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Loratadine.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Loratadine.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Loratadine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Loratadine.
adipiplonThe risk or severity of adverse effects can be increased when adipiplon is combined with Loratadine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Loratadine.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Loratadine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Loratadine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Loratadine.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Loratadine.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Loratadine.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Loratadine.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Loratadine.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Loratadine.
AmiodaroneThe metabolism of Loratadine can be decreased when combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Loratadine.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Loratadine.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Loratadine.
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Loratadine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Loratadine.
AmoxapineThe risk or severity of adverse effects can be increased when Loratadine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Loratadine.
AmphetamineAmphetamine may decrease the sedative activities of Loratadine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Loratadine.
AprepitantThe serum concentration of Loratadine can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Loratadine.
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Loratadine.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Loratadine.
ArtemetherThe metabolism of Loratadine can be decreased when combined with Artemether.
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Loratadine.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Loratadine.
AtazanavirThe metabolism of Loratadine can be decreased when combined with Atazanavir.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Loratadine.
AtenololThe serum concentration of Atenolol can be increased when it is combined with Loratadine.
AtomoxetineThe metabolism of Loratadine can be decreased when combined with Atomoxetine.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Loratadine.
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Loratadine.
AzelastineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Loratadine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Loratadine.
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Loratadine.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Loratadine.
BenzphetamineBenzphetamine may decrease the sedative activities of Loratadine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Loratadine.
Benzylpenicilloyl PolylysineLoratadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Loratadine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Loratadine.
BetaxololThe metabolism of Loratadine can be decreased when combined with Betaxolol.
BexaroteneThe serum concentration of Loratadine can be decreased when it is combined with Bexarotene.
BoceprevirThe metabolism of Loratadine can be decreased when combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Loratadine.
BortezomibThe metabolism of Loratadine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Loratadine can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Loratadine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Loratadine.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Loratadine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
BrimonidineThe risk or severity of adverse effects can be increased when Loratadine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Loratadine.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Loratadine.
BrompheniramineThe risk or severity of adverse effects can be increased when Loratadine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Loratadine.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Loratadine.
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Loratadine.
BupropionThe metabolism of Loratadine can be decreased when combined with Bupropion.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Loratadine.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Loratadine.
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Loratadine.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Loratadine.
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Loratadine.
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Loratadine.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Loratadine.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Loratadine.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Loratadine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Loratadine.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Loratadine.
CapecitabineThe metabolism of Loratadine can be decreased when combined with Capecitabine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Loratadine.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Loratadine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Loratadine is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Loratadine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Loratadine.
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Loratadine.
CelecoxibThe metabolism of Loratadine can be decreased when combined with Celecoxib.
CeritinibThe serum concentration of Loratadine can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Loratadine.
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Loratadine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Loratadine.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Loratadine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Loratadine.
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Loratadine.
ChloroquineThe metabolism of Loratadine can be decreased when combined with Chloroquine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Loratadine is combined with Chlorphenamine.
ChlorphentermineChlorphentermine may decrease the sedative activities of Loratadine.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Loratadine.
ChlorpromazineThe metabolism of Loratadine can be decreased when combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Loratadine.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Loratadine.
CholecalciferolThe metabolism of Loratadine can be decreased when combined with Cholecalciferol.
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Loratadine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Loratadine.
CimetidineThe metabolism of Loratadine can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Loratadine can be decreased when combined with Cinacalcet.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Loratadine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Loratadine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Loratadine.
CitalopramThe risk or severity of adverse effects can be increased when Loratadine is combined with Citalopram.
CitalopramThe metabolism of Loratadine can be decreased when combined with Citalopram.
ClarithromycinThe metabolism of Loratadine can be decreased when combined with Clarithromycin.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Loratadine.
ClemastineThe metabolism of Loratadine can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Loratadine is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Loratadine is combined with Clidinium.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Loratadine.
ClobazamThe metabolism of Loratadine can be decreased when combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Loratadine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Loratadine.
ClomipramineThe risk or severity of adverse effects can be increased when Loratadine is combined with Clomipramine.
ClomipramineThe metabolism of Loratadine can be decreased when combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Loratadine is combined with Clonazepam.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Loratadine.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Loratadine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Loratadine.
ClopidogrelThe metabolism of Loratadine can be decreased when combined with Clopidogrel.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Loratadine.
ClotrimazoleThe metabolism of Loratadine can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Loratadine.
ClozapineThe metabolism of Loratadine can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Loratadine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Loratadine.
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Loratadine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Loratadine.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Loratadine.
ConivaptanThe serum concentration of Loratadine can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Loratadine.
CrizotinibThe metabolism of Loratadine can be decreased when combined with Crizotinib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Loratadine.
CyclizineThe risk or severity of adverse effects can be increased when Loratadine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Loratadine.
CyclosporineThe metabolism of Loratadine can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Loratadine.
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Loratadine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Loratadine.
DabrafenibThe serum concentration of Loratadine can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Loratadine.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Loratadine.
DantroleneThe risk or severity of adverse effects can be increased when Loratadine is combined with Dantrolene.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Loratadine.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Loratadine.
DapoxetineThe risk or severity of adverse effects can be increased when Loratadine is combined with Dapoxetine.
DarifenacinThe metabolism of Loratadine can be decreased when combined with Darifenacin.
DarunavirThe serum concentration of Loratadine can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Loratadine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Loratadine.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Loratadine.
DeferasiroxThe serum concentration of Loratadine can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Loratadine can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when deramciclane is combined with Loratadine.
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Loratadine.
DesipramineThe metabolism of Loratadine can be decreased when combined with Desipramine.
DesipramineThe risk or severity of adverse effects can be increased when Loratadine is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Loratadine.
DexamethasoneThe serum concentration of Loratadine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Loratadine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Loratadine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Loratadine.
DextroamphetamineDextroamphetamine may decrease the sedative activities of Loratadine.
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Loratadine.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Loratadine.
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Loratadine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Loratadine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Loratadine.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Loratadine.
DifenoxinThe risk or severity of adverse effects can be increased when Loratadine is combined with Difenoxin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Loratadine.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Loratadine.
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Loratadine.
DihydroergotamineThe metabolism of Loratadine can be decreased when combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Loratadine.
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Loratadine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Loratadine.
DiltiazemThe metabolism of Loratadine can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Loratadine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Loratadine is combined with Dimenhydrinate.
DiphenhydramineThe metabolism of Loratadine can be decreased when combined with Diphenhydramine.
DiphenhydramineThe risk or severity of adverse effects can be increased when Loratadine is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Loratadine.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Loratadine.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Loratadine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Loratadine.
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Loratadine.
DoxepinThe risk or severity of adverse effects can be increased when Loratadine is combined with Doxepin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Loratadine.
DoxycyclineThe metabolism of Loratadine can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
DoxylamineThe risk or severity of adverse effects can be increased when Loratadine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Loratadine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
DronedaroneThe metabolism of Loratadine can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Loratadine.
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Loratadine.
DuloxetineThe metabolism of Loratadine can be decreased when combined with Duloxetine.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Loratadine.
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Loratadine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when ECGONINE METHYL ESTER is combined with Loratadine.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Loratadine.
EfavirenzThe serum concentration of Loratadine can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Loratadine is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Loratadine.
EliglustatThe metabolism of Loratadine can be decreased when combined with Eliglustat.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Loratadine.
EntacaponeThe risk or severity of adverse effects can be increased when Loratadine is combined with Entacapone.
EnzalutamideThe serum concentration of Loratadine can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Loratadine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Loratadine.
ErythromycinThe metabolism of Loratadine can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Loratadine.
EscitalopramThe risk or severity of adverse effects can be increased when Loratadine is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Loratadine can be decreased when it is combined with Eslicarbazepine acetate.
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Loratadine.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Loratadine.
EstriolThe serum concentration of Estriol can be increased when it is combined with Loratadine.
EstroneThe serum concentration of Estrone can be increased when it is combined with Loratadine.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Loratadine.
EthanolLoratadine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Loratadine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Loratadine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Loratadine.
EthosuximideThe risk or severity of adverse effects can be increased when Loratadine is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Loratadine is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Loratadine.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Loratadine.
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Loratadine.
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Loratadine.
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Loratadine.
EtizolamThe risk or severity of adverse effects can be increased when Etizolam is combined with Loratadine.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Loratadine.
EtoperidoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Etoperidone.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Loratadine.
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Loratadine.
EtravirineThe serum concentration of Loratadine can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Loratadine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Loratadine.
EzogabineThe risk or severity of adverse effects can be increased when Loratadine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Loratadine is combined with Felbamate.
FelodipineThe metabolism of Loratadine can be decreased when combined with Felodipine.
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Loratadine.
FenfluramineThe risk or severity of adverse effects can be increased when Loratadine is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Loratadine.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Loratadine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Loratadine.
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Loratadine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Loratadine.
FlibanserinThe risk or severity of adverse effects can be increased when Loratadine is combined with Flibanserin.
FloxuridineThe metabolism of Loratadine can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Loratadine can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Loratadine.
FlunarizineThe risk or severity of adverse effects can be increased when Loratadine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Loratadine.
FluorouracilThe metabolism of Loratadine can be decreased when combined with Fluorouracil.
FluoxetineThe risk or severity of adverse effects can be increased when Loratadine is combined with Fluoxetine.
FluoxetineThe metabolism of Loratadine can be decreased when combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Loratadine.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Loratadine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Loratadine.
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Loratadine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Loratadine.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Loratadine is combined with Fluticasone Propionate.
FluvastatinThe metabolism of Loratadine can be decreased when combined with Fluvastatin.
FluvoxamineThe risk or severity of adverse effects can be increased when Loratadine is combined with Fluvoxamine.
FluvoxamineThe metabolism of Loratadine can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Loratadine can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Loratadine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe risk or severity of adverse effects can be increased when Loratadine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Loratadine.
Fusidic AcidThe serum concentration of Loratadine can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Loratadine.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Loratadine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Loratadine.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Loratadine.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Loratadine.
GemfibrozilThe metabolism of Loratadine can be decreased when combined with Gemfibrozil.
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Loratadine.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Loratadine.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Loratadine.
GuanfacineThe risk or severity of adverse effects can be increased when Loratadine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Loratadine.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Loratadine.
HaloperidolThe metabolism of Loratadine can be decreased when combined with Haloperidol.
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Loratadine.
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Loratadine.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Loratadine.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Loratadine.
HydrocodoneThe risk or severity of adverse effects can be increased when Hydrocodone is combined with Loratadine.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Loratadine.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Loratadine.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may decrease the sedative activities of Loratadine.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
HydroxyzineThe risk or severity of adverse effects can be increased when Loratadine is combined with Hydroxyzine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Loratadine.
IdelalisibThe serum concentration of Loratadine can be increased when it is combined with Idelalisib.
IloperidoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Iloperidone.
ImatinibThe metabolism of Loratadine can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Loratadine.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Loratadine.
ImipramineThe metabolism of Loratadine can be decreased when combined with Imipramine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Loratadine.
IndalpineThe risk or severity of adverse effects can be increased when Loratadine is combined with Indalpine.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Loratadine.
IndinavirThe metabolism of Loratadine can be decreased when combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Loratadine.
IrbesartanThe metabolism of Loratadine can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Loratadine.
IsavuconazoniumThe metabolism of Loratadine can be decreased when combined with Isavuconazonium.
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Loratadine.
IsoniazidThe metabolism of Loratadine can be decreased when combined with Isoniazid.
IsradipineThe metabolism of Loratadine can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Loratadine can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Loratadine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Loratadine.
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Loratadine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Loratadine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Loratadine.
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Loratadine.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Loratadine.
KetoconazoleThe metabolism of Loratadine can be decreased when combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Loratadine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Loratadine.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Loratadine.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Loratadine.
LapatinibThe metabolism of Loratadine can be decreased when combined with Lapatinib.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Loratadine.
LeflunomideThe metabolism of Loratadine can be decreased when combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Loratadine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Loratadine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Loratadine.
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Loratadine.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Loratadine.
LevocabastineThe risk or severity of adverse effects can be increased when Loratadine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Loratadine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Loratadine is combined with Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Loratadine.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Loratadine.
LevomilnacipranThe risk or severity of adverse effects can be increased when Loratadine is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Loratadine.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Loratadine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Loratadine.
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Loratadine.
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Loratadine.
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Loratadine.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Loratadine.
LopinavirThe metabolism of Loratadine can be decreased when combined with Lopinavir.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Loratadine.
LorcaserinThe metabolism of Loratadine can be decreased when combined with Lorcaserin.
LosartanThe serum concentration of Losartan can be increased when it is combined with Loratadine.
LosartanThe metabolism of Loratadine can be decreased when combined with Losartan.
LovastatinThe metabolism of Loratadine can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Loratadine.
Lu AA21004The risk or severity of adverse effects can be increased when Loratadine is combined with Lu AA21004.
LuliconazoleThe serum concentration of Loratadine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Loratadine can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Loratadine can be decreased when combined with Lumefantrine.
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Loratadine.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Loratadine is combined with Magnesium Sulfate.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Loratadine.
MaprotilineThe risk or severity of adverse effects can be increased when Loratadine is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Loratadine is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Loratadine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Loratadine.
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Loratadine.
MephentermineMephentermine may decrease the sedative activities of Loratadine.
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Loratadine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Loratadine.
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Loratadine.
MetaxaloneThe risk or severity of adverse effects can be increased when Loratadine is combined with Metaxalone.
MethadoneThe metabolism of Loratadine can be decreased when combined with Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Methadone.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Loratadine.
MethamphetamineMethamphetamine may decrease the sedative activities of Loratadine.
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Loratadine.
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Loratadine.
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Loratadine.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Loratadine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Loratadine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Methotrimeprazine is combined with Loratadine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Loratadine.
MethsuximideThe risk or severity of adverse effects can be increased when Loratadine is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Loratadine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Loratadine.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Loratadine.
MetoprololThe metabolism of Loratadine can be decreased when combined with Metoprolol.
MetyrosineLoratadine may increase the sedative activities of Metyrosine.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Loratadine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Loratadine.
MifepristoneThe metabolism of Loratadine can be decreased when combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Loratadine is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Loratadine.
MirabegronThe metabolism of Loratadine can be decreased when combined with Mirabegron.
MirtazapineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Loratadine.
MitotaneThe serum concentration of Loratadine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Loratadine.
ModafinilThe serum concentration of Loratadine can be decreased when it is combined with Modafinil.
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Loratadine.
MorphineThe serum concentration of Morphine can be increased when it is combined with Loratadine.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Loratadine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Loratadine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
NabiloneThe risk or severity of adverse effects can be increased when Loratadine is combined with Nabilone.
NadololThe serum concentration of Nadolol can be increased when it is combined with Loratadine.
NafcillinThe serum concentration of Loratadine can be decreased when it is combined with Nafcillin.
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Loratadine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Loratadine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Loratadine.
NefazodoneThe metabolism of Loratadine can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Loratadine can be decreased when combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Loratadine.
NetupitantThe serum concentration of Loratadine can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Loratadine can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Loratadine.
NicardipineThe metabolism of Loratadine can be decreased when combined with Nicardipine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Loratadine.
NilotinibThe metabolism of Loratadine can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Loratadine.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Loratadine.
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Loratadine.
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Loratadine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Loratadine.
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Loratadine.
NortriptylineThe risk or severity of adverse effects can be increased when Loratadine is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Loratadine is combined with Olanzapine.
OlaparibThe metabolism of Loratadine can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Loratadine is combined with Olopatadine.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Loratadine.
OmeprazoleThe metabolism of Loratadine can be decreased when combined with Omeprazole.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Loratadine.
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Loratadine.
OrphenadrineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Loratadine.
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Loratadine.
OsimertinibThe serum concentration of Loratadine can be increased when it is combined with Osimertinib.
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Loratadine.
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Loratadine.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Loratadine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Loratadine.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Loratadine.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Loratadine.
PalbociclibThe serum concentration of Loratadine can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Loratadine.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Loratadine.
PanobinostatThe metabolism of Loratadine can be decreased when combined with Panobinostat.
ParaldehydeLoratadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Loratadine.
ParoxetineThe risk or severity of adverse effects can be increased when Loratadine is combined with Paroxetine.
ParoxetineThe metabolism of Loratadine can be decreased when combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Loratadine.
Peginterferon alfa-2bThe serum concentration of Loratadine can be decreased when it is combined with Peginterferon alfa-2b.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Loratadine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Loratadine.
PerampanelThe risk or severity of adverse effects can be increased when Loratadine is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Loratadine.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Loratadine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Loratadine.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Loratadine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Loratadine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Loratadine.
PhenterminePhentermine may decrease the sedative activities of Loratadine.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Loratadine.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Loratadine.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Loratadine.
PioglitazoneThe metabolism of Loratadine can be decreased when combined with Pioglitazone.
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Loratadine.
PipotiazineThe risk or severity of adverse effects can be increased when Loratadine is combined with Pipotiazine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Loratadine.
PizotifenThe risk or severity of adverse effects can be increased when Loratadine is combined with Pizotifen.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Loratadine.
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Loratadine.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Loratadine.
PosaconazoleThe metabolism of Loratadine can be decreased when combined with Posaconazole.
PramipexoleLoratadine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Loratadine.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Loratadine.
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Loratadine.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Loratadine.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Loratadine.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Loratadine.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Loratadine.
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Loratadine.
PrimidoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Loratadine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Loratadine.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Loratadine.
PromazineThe metabolism of Loratadine can be decreased when combined with Promazine.
PromazineThe risk or severity of adverse effects can be increased when Loratadine is combined with Promazine.
PromethazineThe risk or severity of adverse effects can be increased when Loratadine is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Loratadine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Loratadine.
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Loratadine.
PropranololThe serum concentration of Propranolol can be increased when it is combined with Loratadine.
ProtriptylineThe risk or severity of adverse effects can be increased when Protriptyline is combined with Loratadine.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Loratadine.
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Loratadine.
PyrimethamineThe metabolism of Loratadine can be decreased when combined with Pyrimethamine.
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Loratadine.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Loratadine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Loratadine.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Loratadine.
QuinidineThe metabolism of Loratadine can be decreased when combined with Quinidine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Loratadine.
QuinineThe metabolism of Loratadine can be decreased when combined with Quinine.
RabeprazoleThe metabolism of Loratadine can be decreased when combined with Rabeprazole.
RamelteonThe risk or severity of adverse effects can be increased when Loratadine is combined with Ramelteon.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Loratadine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Loratadine.
RanolazineThe metabolism of Loratadine can be decreased when combined with Ranolazine.
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Loratadine.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Loratadine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Loratadine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Loratadine.
RifabutinThe metabolism of Loratadine can be increased when combined with Rifabutin.
RifampicinThe metabolism of Loratadine can be increased when combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Loratadine.
RifapentineThe metabolism of Loratadine can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Loratadine.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Loratadine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Loratadine.
RitonavirThe metabolism of Loratadine can be decreased when combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Loratadine.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Loratadine.
RolapitantThe metabolism of Loratadine can be decreased when combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Loratadine.
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Loratadine.
RopiniroleLoratadine may increase the sedative activities of Ropinirole.
RopiniroleThe metabolism of Loratadine can be decreased when combined with Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Loratadine.
RosiglitazoneThe metabolism of Loratadine can be decreased when combined with Rosiglitazone.
RotigotineLoratadine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Loratadine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when S-Ethylisothiourea is combined with Loratadine.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Loratadine.
SaquinavirThe metabolism of Loratadine can be decreased when combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Loratadine.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Loratadine.
ScopolamineThe risk or severity of adverse effects can be increased when Loratadine is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Loratadine.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Loratadine.
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Loratadine.
SertralineThe risk or severity of adverse effects can be increased when Loratadine is combined with Sertraline.
SertralineThe metabolism of Loratadine can be decreased when combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Loratadine.
SildenafilThe metabolism of Loratadine can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Loratadine.
SiltuximabThe serum concentration of Loratadine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Loratadine can be increased when it is combined with Simeprevir.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Loratadine.
Sodium oxybateThe risk or severity of adverse effects can be increased when Sodium oxybate is combined with Loratadine.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Loratadine.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Loratadine.
SorafenibThe metabolism of Loratadine can be decreased when combined with Sorafenib.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Loratadine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Loratadine.
St. John's WortThe serum concentration of Loratadine can be decreased when it is combined with St. John's Wort.
StiripentolThe risk or severity of adverse effects can be increased when Loratadine is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Loratadine.
SulfadiazineThe metabolism of Loratadine can be decreased when combined with Sulfadiazine.
SulfamethoxazoleThe metabolism of Loratadine can be decreased when combined with Sulfamethoxazole.
SulfisoxazoleThe metabolism of Loratadine can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Loratadine.
SuvorexantThe risk or severity of adverse effects can be increased when Loratadine is combined with Suvorexant.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Loratadine.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Loratadine.
TamoxifenThe metabolism of Loratadine can be decreased when combined with Tamoxifen.
TapentadolThe risk or severity of adverse effects can be increased when Loratadine is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Loratadine is combined with Tasimelteon.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Loratadine.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Loratadine.
TelaprevirThe metabolism of Loratadine can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Loratadine.
TelithromycinThe metabolism of Loratadine can be decreased when combined with Telithromycin.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Loratadine.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Loratadine.
TerbinafineThe metabolism of Loratadine can be decreased when combined with Terbinafine.
TeriflunomideThe metabolism of Loratadine can be decreased when combined with Teriflunomide.
TetrabenazineThe risk or severity of adverse effects can be increased when Loratadine is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Loratadine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Loratadine.
ThalidomideLoratadine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Loratadine.
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Loratadine.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Loratadine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Loratadine.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Loratadine.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Loratadine.
TiagabineThe risk or severity of adverse effects can be increased when Loratadine is combined with Tiagabine.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Loratadine.
TicagrelorThe metabolism of Loratadine can be decreased when combined with Ticagrelor.
TiclopidineThe metabolism of Loratadine can be decreased when combined with Ticlopidine.
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Loratadine.
TimololThe serum concentration of Timolol can be increased when it is combined with Loratadine.
TipranavirThe metabolism of Loratadine can be decreased when combined with Tipranavir.
TizanidineThe risk or severity of adverse effects can be increased when Loratadine is combined with Tizanidine.
TocilizumabThe serum concentration of Loratadine can be decreased when it is combined with Tocilizumab.
TolbutamideThe metabolism of Loratadine can be decreased when combined with Tolbutamide.
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Loratadine.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Loratadine.
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Loratadine.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Loratadine.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Loratadine.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Loratadine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Loratadine.
TranylcypromineThe metabolism of Loratadine can be decreased when combined with Tranylcypromine.
TranylcypromineThe risk or severity of adverse effects can be increased when Loratadine is combined with Tranylcypromine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Loratadine.
TrazodoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Loratadine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Loratadine.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Loratadine.
TrimethoprimThe metabolism of Loratadine can be decreased when combined with Trimethoprim.
TrimipramineThe risk or severity of adverse effects can be increased when Loratadine is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Loratadine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Loratadine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Loratadine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Loratadine.
ValsartanThe metabolism of Loratadine can be decreased when combined with Valsartan.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Loratadine.
VenlafaxineThe metabolism of Loratadine can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Loratadine.
VerapamilThe metabolism of Loratadine can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Loratadine.
VigabatrinThe risk or severity of adverse effects can be increased when Loratadine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Vilazodone.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Loratadine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Loratadine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Loratadine.
VoriconazoleThe metabolism of Loratadine can be decreased when combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Loratadine is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Loratadine.
ZafirlukastThe metabolism of Loratadine can be decreased when combined with Zafirlukast.
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Loratadine.
ZiconotideThe risk or severity of adverse effects can be increased when Loratadine is combined with Ziconotide.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Loratadine.
ZimelidineThe risk or severity of adverse effects can be increased when Loratadine is combined with Zimelidine.
ZiprasidoneThe metabolism of Loratadine can be decreased when combined with Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Loratadine is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Loratadine.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Loratadine.
ZonisamideThe risk or severity of adverse effects can be increased when Loratadine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Loratadine.
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Loratadine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Loratadine.
Food Interactions
  • Take on empty stomach: 1 hour before or 2 hours after meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Cieslewicz G, Gondorowicz K, Grzelewska-Rzymowska I, Rozniecki J, Wojciechowska B: [Effect of loratadine--selective antagonist of histamine (H1) receptor--on allergen-induced bronchoconstriction in atopic asthmatics]. Pneumonol Alergol Pol. 1992;60(11-12):11-5. [PubMed:1303772 ]
  3. Cieslewicz G, Gondorowicz K, Grzelewska-Rzymowska I, Rozniecki J: [Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction]. Pneumonol Alergol Pol. 1995;63(5-6):281-5. [PubMed:7581058 ]
  4. Letari O, Miozzo A, Folco G, Belloni PA, Sala A, Rovati GE, Nicosia S: Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity. Eur J Pharmacol. 1994 Feb 15;266(3):219-27. [PubMed:8174605 ]
  5. Cavero I, Mestre M, Guillon JM, Heuillet E, Roach AG: Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans? Drug Saf. 1999;21 Suppl 1:19-31; discussion 81-7. [PubMed:10597865 ]
  6. Tamura T, Masaki S, Ohmori K, Karasawa A: Effect of olopatadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeated topical application of oxazolone in mice. Pharmacology. 2005 Dec;75(1):45-52. Epub 2005 Jun 7. [PubMed:15942272 ]
  7. Grzelewska-Rzymowska I, Gondorowicz K, Cieslewicz G, Rozniecki J, Wojciechowska B: [Effect of loratadine (LO), a selective H1 antagonist, on histamine-induced bronchoconstriction]. Pneumonol Alergol Pol. 1992;60(11-12):16-21. [PubMed:1303773 ]
  8. Menardo JL, Horak F, Danzig MR, Czarlewski W: A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. [PubMed:9444440 ]
  9. Howarth PH: Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy. 1990 Aug;20 Suppl 2:31-41. [PubMed:1977506 ]
  10. Baroody FM, Naclerio RM: Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. [PubMed:11291777 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Warzecha H, Ferme D, Peer M, Frank A, Unger M: Bioconversion of the antihistaminc drug loratadine by tobacco cell suspension cultures expressing human cytochrome P450 3A4. J Biosci Bioeng. 2010 Mar;109(3):288-90. doi: 10.1016/j.jbiosc.2009.09.001. Epub 2009 Sep 29. [PubMed:20159579 ]
  2. Li C, Lee MY, Choi JS: Effects of silybinin, CYP3A4 and P-glycoprotein inhibitor in vitro, on the bioavailability of loratadine in rats. Pharmazie. 2010 Jul;65(7):510-4. [PubMed:20662320 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Barecki ME, Casciano CN, Johnson WW, Clement RP: In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1173-5. [PubMed:11502723 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Barecki ME, Casciano CN, Johnson WW, Clement RP: In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1173-5. [PubMed:11502723 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein. Drug Metab Dispos. 2001 Aug;29(8):1080-3. [PubMed:11454724 ]
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Drug created on June 13, 2005 07:24 / Updated on August 30, 2016 02:11