| Identification |
|---|
| Name |
Pseudoephedrine |
| Accession Number |
DB00852
(APRD00634)
|
| Type |
small molecule |
| Groups |
approved |
| Description |
An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem] |
| Structure |
Download:
MOL |
SDF |
SMILES |
InChI
Display:
2D Structure |
3D Structure
|
| Synonyms |
Not Available |
| Brand names |
- Afrin
- Afrinol
- Balminil Decongestant Syrup
- Benylin Decongestant
- Besan
- Cenafed
- Chlor-Trimeton
- D-Isoephedrine
- D-Pseudoephedrine
- Decofed
- Dimetapp Decongestant
- Dimetapp Decongestant Pediatric Drops
- Drixoral N.D.
- Drixoral Nasal Decongestant
- Efidac 24 Pseudoephedrine Hcl
- Efidac/24
- Eltor 120
- Genaphed
- Isoephedrine
- Maxenal
- Myfedrine
- Novafed
- Pedia Care
- Pseudo
- Pseudo 60's
- Pseudo-12
- Pseudoefedrina [INN-Spanish]
- Pseudoephedrine D-Form
- Pseudoephedrine Ephedrine
- Pseudoephedrine Hcl
- Pseudoephedrinum [INN-Latin]
- Psi-Ephedrin
- Psi-Ephedrine
- Robidrine
- Sudafed
- Sudafed 12 Hour
- Sudafed Decongestant
- Sudafed Decongestant 12 Hour
- Sudafed Decongestant Extra Strength
- Trans-Ephedrine
- Triaminic AM Decongestant Formula
- Triaminic Infant Oral Decongestant Drops
|
| Brand name mixtures |
- Actifed DM Syrup (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride)
- Actifed DM Tablets (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride)
- Actifed Plus Caplet (Acetaminophen + Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride)
- Actifed Syrup (Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride)
- Actifed Tablets (Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride)
- Allergy Sinus Medication - Caplet (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride)
- Benadryl Decongestant Tablets (Diphenhydramine Hydrochloride + Pseudoephedrine Hydrochloride)
- Benylin 4 Flu - Syrup (Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Benylin Codeine 3.3mg de Syr (Codeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride)
- Bronchodex Pediatrique (Dextromethorphan Hydrobromide + Guaifenesin + Pheniramine Maleate + Pseudoephedrine Hydrochloride)
- Calmylin #2 Syr (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Calmylin #3 Syr (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Calmylin Codeine D-E Syr (Codeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride)
- Calmylin Cough and Flu Liq (Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Calmylin Pediatric Syrup (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Centracol Pediatrique - Syr (Dextromethorphan Hydrobromide + Guaifenesin + Pheniramine Maleate + Pseudoephedrine Hydrochloride)
- Children's Tussin Cough Medicine DM Antitussive Decongestant (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Children's Tylenol Allergy - D Chewable Tablets (Acetaminophen + Diphenhydramine Hydrochloride + Pseudoephedrine Hydrochloride)
- Children's Tylenol Allergy-D Suspension (Acetaminophen + Diphenhydramine Hydrochloride + Pseudoephedrine Hydrochloride)
- Children's Tylenol Cold Liquid (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride)
- Children's Tylenol Cold Liquid with DM (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Children's Tylenol Sinus Chewable Tablet (Acetaminophen + Pseudoephedrine Hydrochloride)
- Clarinex-D 12 Hour Extended Release Tablets (desloratadine + pseudoephedrine)
- Claritin Allergy + Sinus Extra Strength (Loratadine + Pseudoephedrine Sulfate)
- Cold/Flu Relief (Acetaminophen + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Contac Day & Night Sinus/Allergy Caplet (Acetaminophen + Diphenhydramine Hydrochloride + Pseudoephedrine Hydrochloride)
- Contac-C Ext.Stren.Night Time Cough,Cold&Flu (Acetaminophen + Diphenhydramine Hydrochloride + Pseudoephedrine Hydrochloride)
- Cotrifed (Codeine Phosphate + Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride)
- Cough and Flu Syrup (Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Cough Syr W.Cod. Pseudoephed.Hcl Guaifenesin (Codeine Phosphate + Guaifenesin + Pseudoephedrine Hydrochloride)
- Cough Syrup DM Decongestant (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Cough Syrup DM Decongestant Expectorant (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Cough Syrup DM Decongestant for Children (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Cough Syrup DM-D-E (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Demdec Syr (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Dimetapp Children's Cough and Cold Liquid (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Dimetapp Cold and Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
- DM Cough Syrup Decongestant (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- DM Plus Decongestant Cough Syrup (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- DM Plus Decongestant Plus Expector.Ex.St.Syr (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- DM Plus Decongestant Plus Expectorant Cough Syrup (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- DM-D-Expectorant Cough and Cold Syrup (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Dristan Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
- Extra Strength Allergy Plus Sinus Relief (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride)
- Extra Strength Allergy Sinus Medication (Acetaminophen + Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride)
- Extra Strength Cold Medication Daytime Rlf (Acetaminophen + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Extra Strength Daytime Cold Relief-Caplet (Acetaminophen + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Extra Strength Nighttime Cold Relief-Caplet (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Extra Strength Sinus Medication-Caplet (Acetaminophen + Pseudoephedrine Hydrochloride)
- Extra Strength Sinus Relief-Caplet (Acetaminophen + Pseudoephedrine Hydrochloride)
- Extra Strength Tylenol Cold and Flu Powder (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Extra Strength Tylenol Sinus Nighttime Caplet (Acetaminophen + Doxylamine Succinate + Pseudoephedrine Hydrochloride)
- Ibuprofen and Pseudoephedrine (Ibuprofen + Pseudoephedrine Hydrochloride)
- Koffex DM + Decongestant + Expectorant (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Koffex DM + Decongestant + Expectorant Extra Strength (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Koffex DM + Decongestant Syrup (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Koffex DM-D-E - Liq (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Medicament Sinus Personnel Ex-Fort Caplet (Acetaminophen + Pseudoephedrine Hydrochloride)
- Medicament Sinus Personnel Reg Caplet (Acetaminophen + Pseudoephedrine Hydrochloride)
- Nasal Decongestant Antihistamine (Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride)
- Neo Citran Daycaps Extra Strength - Caplet (Acetaminophen + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Nighttime Cold and Flu Liquid Capsules (Acetaminophen + Dextromethorphan Hydrobromide + Doxylamine Succinate + Pseudoephedrine Hydrochloride)
- Nighttime Cold and Flu Relief (Acetaminophen + Dextromethorphan Hydrobromide + Doxylamine Succinate + Pseudoephedrine Hydrochloride)
- Nitetime Cold Medicine (Acetaminophen + Dextromethorphan Hydrobromide + Doxylamine Succinate + Pseudoephedrine Hydrochloride)
- Novahistex DM Expectorant with Decongestant (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Novahistex DM with Decongestant (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Novahistex Expectorant with Decongestant (Guaifenesin + Pseudoephedrine Hydrochloride)
- Novahistine DM Expectorant with Decongestant (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Novahistine DM with Decongestant - Liq (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Nyquil Liquicaps (Acetaminophen + Dextromethorphan Hydrobromide + Doxylamine Succinate + Pseudoephedrine Hydrochloride)
- Once-a-Day Benylin Cold Cap (Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride)
- Pediatric Cough Syrup (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Personnelle DM Syr (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Promatussin DM Adult Formula Syr (Dextromethorphan Hydrobromide + Promethazine Hydrochloride + Pseudoephedrine Hydrochloride)
- Promatussin DM Children Formula (Dextromethorphan Hydrobromide + Promethazine Hydrochloride + Pseudoephedrine Hydrochloride)
- Pulmosirum Decongestionnant Sirop (Beechwood Creosote + Cocillana + Eucalyptus + Guaiacol + Ipecac + Lobelia Inflata + Menthol + Myroxylon Balsamum + Pseudoephedrine Hydrochloride + White Pine)
- Reg.Str.Cold Medic. (Night Time Relief)Caplet (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Regular Strength Cold Medication (Daytime R.) (Acetaminophen + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Regular Strength Sinus Medication (Acetaminophen + Pseudoephedrine Hydrochloride)
- Regular Strength Sinus Medication-Caplet (Acetaminophen + Pseudoephedrine Hydrochloride)
- Regular Strength Tylenol Cold and Flu Powder (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Regular Strength Tylenol Cold Chest Congestion (Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Regular Strength Tylenol Cough Suspension with Decongestant (Acetaminophen + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Robitussin Honey Cough and Cold (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Robitussin Honey Flu (Acetaminophen + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Sinus, Pain & Nasal Congest Relief Caplet (Acetaminophen + Pseudoephedrine Hydrochloride)
- Sinutab N.T. Regular Strength Caplets (Acetaminophen + Diphenhydramine Hydrochloride + Pseudoephedrine Hydrochloride)
- Sudafed Cold and Cough Extra Strength Caplet (Acetaminophen + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Sudafed Cold and Flu Gel Caps (Acetaminophen + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Sudafed DM (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Sudafed Head Cold and Sinus Extra Strength Caplets (Acetaminophen + Pseudoephedrine Hydrochloride)
- Sudafed Sinus Extra Strength (Acetaminophen + Pseudoephedrine Hydrochloride)
- Theraflu Flu Cold and Cough Medicine (Acetaminophen + Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Triaminic Cold and Allergy (Chlorpheniramine Maleate + Pseudoephedrine Hydrochloride)
- Triaminic Decongest+Expect Liqui-Gels Cap (Guaifenesin + Pseudoephedrine Hydrochloride)
- Triaminic DM Expectorant Syr (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
- Triaminic DM Plus Decongestant Syrup (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Triaminic DM+Decongestant Liqui-Gels Capsules (Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Triaminic Expectorant Syr (Chlorpheniramine Maleate + Guaifenesin + Pseudoephedrine Hydrochloride)
- Triaminicol DM Syrup (Chlorpheniramine Maleate + Dextromethorphan Hydrobromide + Pseudoephedrine Hydrochloride)
- Triprofed Tab (Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride)
- Tussin Cough Medicine DM Antitussive Expectorant Decongestant (Dextromethorphan Hydrobromide + Guaifenesin + Pseudoephedrine Hydrochloride)
|
| Categories |
- Vasoconstrictor Agents
- Adrenergic Agents
- Sympathomimetics
- Central Nervous System Agents
- Bronchodilator Agents
- Nasal Decongestants
|
| CAS number |
90-82-4 |
| Weight |
Average: 165.2322
Monoisotopic: 165.115364107
|
| Chemical Formula |
C10H15NO |
| InChI Key |
InChIKey=KWGRBVOPPLSCSI-WCBMZHEXSA-N |
| InChI |
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1
Plain Text
|
| IUPAC Name |
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
|
| SMILES |
CN[C@@H](C)[C@@H](O)C1=CC=CC=C1
Plain Text
|
| Mass Spec |
show (8.2 KB)
|
| Taxonomy |
|---|
| Kingdom |
Organic |
| Classes |
- Phenethylamines
- Amphetamines
|
| Substructures |
- Hydroxy Compounds
- Benzyl Alcohols and Derivatives
- Aliphatic and Aryl Amines
- Benzene and Derivatives
- Amino Alcohols
- Phenethylamines
- Aromatic compounds
- Alcohols and Polyols
- Amphetamines
|
| Pharmacology |
|---|
| Indication |
For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism. |
| Pharmacodynamics |
Pseudoephedrine is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/ibuprofen. Unlike antihistamines, which modify the systemic histamine-mediated allergic response, pseudoephedrine only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral pseudoephedrine over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa). |
| Mechanism of action |
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors. |
| Absorption |
Pseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism. |
| Volume of distribution |
Not Available |
| Protein binding |
Pseudoephedrine does not bind to human plasma proteins over the concentration range of 50 to 2000 ng/mL |
| Metabolism |
Hepatic.
|
| Route of elimination |
Not Available |
| Half life |
9-16 hours |
| Clearance |
Not Available |
| Toxicity |
Common adverse reactions include nervousness, restlessness, and insomnia. Rare adverse reactions include difficult/painful urination, dizziness/lightheadedness, heart palpitations, headache, increased sweating, nausea/vomiting, trembling, troubled breathing, unusual paleness, and weakness. |
| Affected organisms |
|
| Pathways |
Not Available |
| Pharmacoeconomics |
|---|
| Manufacturers |
- Ucb inc
- Schering plough healthcare products inc
|
| Packagers |
|
| Dosage forms |
| Form |
Route |
Strength |
| Liquid |
Oral |
|
| Syrup |
Oral |
|
| Tablet |
Oral |
|
| Tablet, extended release |
Oral |
|
|
| Prices |
| Unit description |
Cost |
Unit |
| Sudafed 24 hour tablet |
0.84 USD |
tablet |
| Pseudoephedrine hcl crystal |
0.67 USD |
g |
| Afrin 0.05% nose spray |
0.62 USD |
ml |
| Sudafed 12 hr sinus-pain caplet |
0.53 USD |
caplet |
| Drixoral cold & allergy tablet sa |
0.4 USD |
tablet |
| Sudafed om sinus nasal spray |
0.4 USD |
ml |
| Afrin no drip sinus pump mist |
0.38 USD |
ml |
| Sudafed pe cold & cough caplet |
0.34 USD |
caplet |
| Afrin sinus spray |
0.33 USD |
ml |
| Chlor-trimeton allergy |
0.31 USD |
each |
| Sudafed pe severe cold caplet |
0.28 USD |
caplet |
| Guaifenesin-phenylephrine tablet |
0.27 USD |
tablet |
| Dimetapp cold-allergy tablet chew |
0.25 USD |
tablet |
| Sudafed pe 10 mg tablet |
0.25 USD |
tablet |
| Chlor-trimeton 8 mg repetab |
0.24 USD |
tablet |
| Sudafed pe day & night tablet |
0.24 USD |
tablet |
| Sudafed triple action caplet |
0.23 USD |
caplet |
| Sudafed pe nighttime cold caplet |
0.22 USD |
caplet |
| Sudafed non-drying sinus caplet |
0.2 USD |
caplet |
| Sudafed pe sinus & allergy tablet |
0.2 USD |
tablet |
| Sudafed pe sinus headache caplet |
0.2 USD |
caplet |
| Sudafed 30 mg tablet |
0.19 USD |
tablet |
| Wal-phed 30 mg tablet |
0.17 USD |
tablet |
| Suphedrin 30 mg tablet |
0.15 USD |
tablet |
| CVS Pharmacy decongestant 30 mg tablet |
0.12 USD |
tablet |
| Sudogest 60 mg tablet |
0.12 USD |
tablet |
| Medi-phedrine 30 mg tablet |
0.1 USD |
tablet |
| Nasal decongestant 30 mg tablet |
0.1 USD |
tablet |
| Genaphed plus tablet |
0.09 USD |
tablet |
| CVS Pharmacy nasal decongest 30 mg tablet |
0.07 USD |
tablet |
| Genaphed 30 mg tablet |
0.07 USD |
tablet |
| Pseudoephedrine gg syrup |
0.07 USD |
ml |
| Pseudoephedrine 60 mg tablet |
0.06 USD |
tablet |
| Children's sudafed pe liquid |
0.05 USD |
ml |
| Pseudoephedrine 30 mg tablet |
0.05 USD |
tablet |
| Dimetapp cold & cough liquid |
0.04 USD |
ml |
| Dimetapp dm cold & cough elix |
0.04 USD |
ml |
| Dimetapp long-acting cough liquid |
0.04 USD |
ml |
| Suphedrine 30 mg tablet |
0.04 USD |
tablet |
|
| Patents |
Not Available |
| Properties |
|---|
| State |
solid |
| Melting point |
117 - 118 oC |
| Experimental Properties |
|
| Predicted Properties |
|
| References |
|---|
| Synthesis Reference |
Not Available
|
| General Reference |
Not Available
|
| External Links |
|
| ATC Codes |
|
| AHFS Codes |
|
| PDB Entries |
Not Available |
| FDA label |
Not Available
|
| MSDS |
show (52.7 KB)
|
| Interactions |
|---|
| Drug Interactions |
Not Available |
| Food Interactions |
- Take without regard to meals.
|
| Targets |
|---|
1. Sodium-dependent noradrenaline transporter
Pharmacological action: yes
Actions: inhibitor
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals
Organism class: human
UniProt ID: P23975 
Gene: SLC6A2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
- Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. Pubmed
- Foley KF, Van Dort ME, Sievert MK, Ruoho AE, Cozzi NV: Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers. J Neural Transm. 2002 Oct;109(10):1229-40. Pubmed
2. Sodium-dependent dopamine transporter
Pharmacological action: yes
Actions: inhibitor
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals
Organism class: human
UniProt ID: Q01959
Gene: SLC6A3
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
- Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. Pubmed
- Foley KF, Van Dort ME, Sievert MK, Ruoho AE, Cozzi NV: Stereospecific inhibition of monoamine uptake transporters by meta-hydroxyephedrine isomers. J Neural Transm. 2002 Oct;109(10):1229-40. Pubmed
3. Alpha-1A adrenergic receptor
Pharmacological action: yes
Actions: agonist
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins
Organism class: human
UniProt ID: P35348
Gene: ADRA1A
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
- Wellington K, Jarvis B: Cetirizine/pseudoephedrine. Drugs. 2001;61(15):2231-40; discussion 2241-2. Pubmed
4. Alpha-2A adrenergic receptor
Pharmacological action: yes
Actions: agonist
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol
Organism class: human
UniProt ID: P08913
Gene: ADRA2A
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
5. Sodium-dependent serotonin transporter
Pharmacological action: yes
Actions: inhibitor
Terminates the action of serotonine by its high affinity sodium-dependent reuptake into presynaptic terminals
Organism class: human
UniProt ID: P31645
Gene: SLC6A4
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
- Wee S, Ordway GA, Woolverton WL: Reinforcing effect of pseudoephedrine isomers and the mechanism of action. Eur J Pharmacol. 2004 Jun 16;493(1-3):117-25. Pubmed
6. Beta-2 adrenergic receptor
Pharmacological action: unknown
Actions: partial agonist
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
Organism class: human
UniProt ID: P07550
Gene: ADRB2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
- Vansal SS, Feller DR: Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes. Biochem Pharmacol. 1999 Sep 1;58(5):807-10. Pubmed
7. Beta-1 adrenergic receptor
Pharmacological action: unknown
Actions: agonist, partial agonist
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity
Organism class: human
UniProt ID: P08588
Gene: ADRB1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report
References:
- Vansal SS, Feller DR: Direct effects of ephedrine isomers on human beta-adrenergic receptor subtypes. Biochem Pharmacol. 1999 Sep 1;58(5):807-10. Pubmed
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