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Identification
NameCelecoxib
Accession NumberDB00482  (APRD00373)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name Celebrex. In some countries, it is branded Celebra. Celecoxib is available by prescription in capsule form.

Structure
Thumb
Synonyms
Celebrex
Celecoxib
Célécoxib
Celecoxibum
P-(5-P-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
External Identifiers
  • SC 58635
  • YM 177
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Accel-celecoxibcapsule200 mgoralAccel Pharma Inc2015-03-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Accel-celecoxibcapsule100 mgoralAccel Pharma Inc2015-03-26Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Celecoxibcapsule200 mgoralActavis Pharma Company2014-11-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Act Celecoxibcapsule100 mgoralActavis Pharma Company2014-11-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ag-celecoxibcapsule200 mgoralAngita Pharma Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ag-celecoxibcapsule100 mgoralAngita Pharma Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-celecoxibcapsule100 mgoralAuro Pharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Auro-celecoxibcapsule200 mgoralAuro Pharma IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bio-celecoxibcapsule200 mgoralBiomed Pharma2014-12-05Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Bio-celecoxibcapsule100 mgoralBiomed Pharma2014-12-05Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celebrexcapsule200 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule50 mg/1oralG.D. Searle LLC Division of Pfizer Inc1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralRebel Distributors Corp.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralCardinal Health1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralH.J. Harkins Company, Inc.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralKeltman Pharmaceuticals Inc.2006-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralCardinal Health1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralUnit Dose Services1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralCardinal Health1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mgoralPfizer Canada Inc1999-04-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celebrexcapsule400 mg/1oralbryant ranch prepack1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralPhysicians Total Care, Inc.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralSTAT Rx USA LLC1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mgoralPfizer Canada Inc1999-04-19Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celebrexcapsule100 mg/1oralbryant ranch prepack1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralUnit Dose Services1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralbryant ranch prepack1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule400 mg/1oralG.D. Searle LLC Division of Pfizer Inc1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralPhysicians Total Care, Inc.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralSTAT Rx USA LLC1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralClinical Solutions Wholesale1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralProficient Rx LP1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralG.D. Searle LLC Division of Pfizer Inc1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralA S Medication Solutions Llc1999-01-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralAidarex Pharmaceuticals LLC1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralAphena Pharma Solutions Tennessee, Llc1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralPd Rx Pharmaceuticals, Inc.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralSTAT Rx USA LLC1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralG.D. Searle LLC Division of Pfizer Inc1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralA S Medication Solutions Llc1999-01-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralRebel Distributors Corp.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralPd Rx Pharmaceuticals, Inc.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralREMEDYREPACK INC.2013-02-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralDispensing Solutions, Inc.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralH.J. Harkins Company, Inc.1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule200 mg/1oralPreferred Pharmaceuticals, Inc.2014-08-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celebrexcapsule100 mg/1oralSTAT Rx USA LLC1998-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mgoralSivem Pharmaceuticals Ulc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule200 mg/1oralAidarex Pharmaceuticals LLC2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralPreferred Pharmaceuticals, Inc.2014-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mgoralPro Doc Limitee2014-11-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule200 mgoralLaboratoire Riva IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule200 mg/1oralMedsource Pharmaceuticals2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralbryant ranch prepack2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralMylan Pharmaceuticals Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralGreenstone LLC2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralBlenheim Pharmacal, Inc.2015-07-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mgoralLaboratoire Riva IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule100 mg/1oralPd Rx Pharmaceuticals, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralbryant ranch prepack2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralMylan Pharmaceuticals Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralGreenstone LLC2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralLupin Pharmaceuticals, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralBlenheim Pharmcal, Inc2015-05-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mgoralSanis Health Inc2015-02-05Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule200 mg/1oralPd Rx Pharmaceuticals, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralMylan Pharmaceuticals Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralGreenstone LLC2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralUnit Dose Services2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralLupin Pharmaceuticals, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralBlenheim Pharmacal, Inc.2015-05-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mgoralSanis Health Inc2015-02-05Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule50 mg/1oralMylan Pharmaceuticals Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralLupin Pharmaceuticals, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralActavis Pharma, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule50 mg/1oralGreenstone LLC2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralAvera Mc Kennan Hospital2015-05-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralAvera Mc Kennan Hospital2015-10-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralLupin Pharmaceuticals, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralActavis Pharma, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mgoralAlembic Pharmaceuticals LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule200 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule200 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralActavis Pharma, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralAidarex Pharmaceuticals LLC2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralPreferred Pharmaceuticals Inc.2015-10-06Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mgoralSivem Pharmaceuticals Ulc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule100 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule100 mg/1oralPreferred Pharmaceuticals, Inc.2014-12-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mgoralPro Doc Limitee2014-11-21Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule50 mg/1oralActavis Pharma, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralREMEDYREPACK INC.2015-02-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Dom-celecoxibcapsule200 mgoralDominion PharmacalNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Dom-celecoxibcapsule100 mgoralDominion PharmacalNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gd-celecoxibcapsule200 mgoralGenmed A Division Of Pfizer Canada Inc2014-11-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Gd-celecoxibcapsule100 mgoralGenmed A Division Of Pfizer Canada Inc2014-11-20Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-celecoxibcapsule100 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ipg-celecoxibcapsule200 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-celecoxibcapsule200 mgoralJamp Pharma Corporation2014-11-27Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Jamp-celecoxibcapsule100 mgoralJamp Pharma Corporation2014-11-27Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lupin-celecoxibcapsule200 mgoralLupin Pharma Canada LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Lupin-celecoxibcapsule100 mgoralLupin Pharma Canada LimitedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-celecoxibcapsule200 mgoralMarcan Pharmaceuticals Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mar-celecoxibcapsule100 mgoralMarcan Pharmaceuticals Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-celecoxibcapsule100 mgoralMint Pharmaceuticals Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mint-celecoxibcapsule200 mgoralMint Pharmaceuticals Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-celecoxibcapsule200 mgoralMylan Pharmaceuticals Ulc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Mylan-celecoxibcapsule100 mgoralMylan Pharmaceuticals Ulc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-celecoxibcapsule200 mgoralPharmascience Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-celecoxibcapsule100 mgoralPharmascience Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Priva-celecoxibcapsule200 mgoralPharmapar Inc2014-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Priva-celecoxibcapsule100 mgoralPharmapar Inc2014-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-celecoxibcapsule200 mgoralRanbaxy Pharmaceuticals Canada Inc.2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Ran-celecoxibcapsule100 mgoralRanbaxy Pharmaceuticals Canada Inc.2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Rbx-celecoxibcapsule200 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Rbx-celecoxibcapsule100 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-celecoxcapsule200 mgoralLaboratoire Riva Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-celecoxcapsule100 mgoralLaboratoire Riva Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-celecoxibcapsule200 mgoralLaboratoire Riva IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Riva-celecoxibcapsule100 mgoralLaboratoire Riva IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Celecoxibcapsule200 mgoralSandoz Canada Incorporated2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sandoz Celecoxibcapsule100 mgoralSandoz Canada Incorporated2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sdz Celecoxibcapsule200 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Sdz Celecoxibcapsule100 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-celecoxibcapsule200 mgoralTeva Canada Limited2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Teva-celecoxibcapsule100 mgoralTeva Canada Limited2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-celecoxibcapsule200 mgoralApotex Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Apo-celecoxibcapsule100 mgoralApotex Inc2014-11-17Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Celecoxibcapsule100 mg/1oralTeva Pharmaceuticals USA Inc2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralAlembic Pharmaceuticals Inc.2015-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralTorrent Pharmaceuticals Limited2015-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralLupin Pharmaceuticals, Inc.2015-08-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralAv Kare, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralMylan Pharmaceuticals Inc.2015-04-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralApotex Corp.2015-06-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralBlenheim Pharmacal, Inc.2015-11-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralAmerican Health Packaging2015-02-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralAv Kare, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralAlembic Pharmaceuticals Limited2015-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralMylan Pharmaceuticals Inc.2015-04-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralApotex Corp.2015-06-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralMajor Pharmaceuticals2015-06-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralAmerican Health Packaging2015-02-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralTrigen Laboratories, LLC2015-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralAlembic Pharmaceuticals Limited2015-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralMylan Pharmaceuticals Inc.2015-04-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralPreferred Pharmaceuticals Inc.2016-01-042016-01-07Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralApotex Corp.2015-06-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralMajor Pharmaceuticals2015-06-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralProficient Rx LP2015-06-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralTrigen Laboratories, LLC2015-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralAlembic Pharmaceuticals Limited2015-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralMylan Pharmaceuticals Inc.2015-04-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralAurobindo Pharma Limited2016-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralActavis Pharma, Inc.2015-03-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralPreferred Pharmaceuticals Inc.2015-10-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralMylan Institutional Inc.2015-02-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralAlembic Pharmaceuticals Limited2015-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralTeva Pharmaceuticals USA Inc2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralProficient Rx LP2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralTrigen Laboratories, LLC2015-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralAurobindo Pharma Limited2016-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralActavis Pharma, Inc.2015-03-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralLupin Pharmaceuticals, Inc.2015-08-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralMylan Institutional Inc.2015-02-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralTeva Pharmaceuticals USA Inc2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralAlembic Pharmaceuticals Inc.2015-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralTrigen Laboratories, LLC2015-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralAurobindo Pharma Limited2016-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralActavis Pharma, Inc.2015-03-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralLupin Pharmaceuticals, Inc.2015-08-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralAv Kare, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralAlembic Pharmaceuticals Inc.2015-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule400 mg/1oralTorrent Pharmaceuticals Limited2015-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralTeva Pharmaceuticals USA Inc2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralAlembic Pharmaceuticals Inc.2015-12-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralTorrent Pharmaceuticals Limited2015-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule100 mg/1oralLupin Pharmaceuticals, Inc.2015-08-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralAv Kare, Inc.2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralAurobindo Pharma Limited2016-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralActavis Pharma, Inc.2015-03-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule200 mg/1oralSt. Mary's Medical Park Pharmacy2014-12-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxibcapsule50 mg/1oralTorrent Pharmaceuticals Limited2015-12-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxib 100 mgcapsule100 mg/1oralSydon Labs Llc2015-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxib 200 mgcapsule200 mg/1oralPreferred Pharmaceuticals Inc.2016-01-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxib 200 mgcapsule200 mg/1oralProficient Rx LP2015-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxib 200 mgcapsule200 mg/1oralSydon Labs Llc2015-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxib 400 mgcapsule400 mg/1oralSydon Labs Llc2015-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Celecoxib 50 mgcapsule50 mg/1oralSydon Labs Llc2015-11-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
ArticoxKeyfarm
ArticoxibNabiqasim
ArtiflexStandpharm
ArtilogPfizer
ArtixPharmalab
ArtrixibIntipharma
BlocktenInfarmasa
CaditarFarmindustria
CefinixFarmacoop
CelactSun
CelebraPfizer
OnsenalPfizer
ValdynePfizer
Brand mixturesNot Available
SaltsNot Available
CategoriesNot Available
UNIIJCX84Q7J1L
CAS number169590-42-5
WeightAverage: 381.372
Monoisotopic: 381.075882012
Chemical FormulaC17H14F3N3O2S
InChI KeyInChIKey=RZEKVGVHFLEQIL-UHFFFAOYSA-N
InChI
InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
IUPAC Name
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
SMILES
CC1=CC=C(C=C1)C1=CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C(F)(F)F
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzoles
Sub ClassPyrazoles
Direct ParentPhenylpyrazoles
Alternative Parents
Substituents
  • Phenylpyrazole
  • Benzenesulfonamide
  • Toluene
  • Benzenoid
  • Monocyclic benzene moiety
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Azacycle
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor relief and management of osteoarthritis (OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, acute pain, primary dysmenorrhea and oral adjunct to usual care for patients with familial adenomatous polyposis
PharmacodynamicsCelecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug (NSAID). Celecoxib is used to treat rheumatoid arthritis, osteoarthritis, and familial adenomatous polyposis (FAP). Because of its lack of platelet effects, celecoxib is not a substitute for aspirin for cardiovascular prophylaxis. It is not known if there are any effects of celecoxib on platelets that may contribute to the increased risk of serious cardiovascular thrombotic adverse events associated with the use of celecoxib. Inhibition of PGE2 synthesis may lead to sodium and water retention through increased fluid reabsorption in the renal medullary thick ascending loop of Henle and perhaps other segments of the distal nephron. In the collecting ducts, PGE2 appears to inhibit water reabsorption by counteracting the action of antidiuretic hormone.
Mechanism of actionThe mechanism of action of celecoxib is believed to be due to inhibition of prostaglandin synthesis. Unlike most NSAIDs, which inhibit both types of cyclooxygenases (COX-1 and COX-2), celecoxib is a selective noncompetitive inhibitor of cyclooxygenase-2 (COX-2) enzyme. It binds with its polar sulfonamide side chain to a hydrophilic side pocket region close to the active COX-2 binding site. Both COX-1 and COX-2 catalyze the conversion of arachidonic acid to prostaglandin (PG) H2, the precursor of PGs and thromboxane.
AbsorptionWell absorbed in the gastrointestinal tract. When a single dose of 200 mg is given to healthy subjects, peak plasma levels occur 3 hours after an oral dose. The peak plasma level is 705 ng/mL. Absolute bioavailability studies have not been conducted. When multiple doses are given, steady-state is reached on or before Day 5. When taken with a high fat meal, peak plasma levels are delayed for about 1 to 2 hours with an increase in total absorption (AUC) of 10% to 20%.
Volume of distribution

Apparent volume of distribution at steady state (Vdss/F), 200 mg single dose, healthy subjects = 429 L

Protein binding97%, primarily to albumin and, to a lesser extent, a1-acid glycoprotein. Celecoxib is not preferentially bound to red blood cells.
Metabolism

Hepatic. Celecoxib metabolism is primarily mediated via cytochrome P450 2C9. Three metabolites, a primary alcohol, the corresponding carboxylic acid and its glucuronide conjugate, have been identified in human plasma. CYP3A4 is also involved in the hydroxylation of celecoxib but to a lesser extent. These metabolites are inactive as COX-1 or COX-2 inhibitors.

SubstrateEnzymesProduct
Celecoxib
HydroxycelecoxibDetails
Hydroxycelecoxib
CarboxycelecoxibDetails
Carboxycelecoxib
Celecoxib glucuronideDetails
Route of eliminationCelecoxib is eliminated predominantly by hepatic metabolism with little (<3%) unchanged drug recovered in the urine and feces. 57% of the oral dose is excreted in the feces and 27% is excreted into the urine. The primary metabolite in urine and feces was the carboxylic acid metabolite (73%). The amount of glucuronide in the urine is low.
Half lifeThe effective half-life is approximately 11 hours when a single 200 mg dose is given to healthy subjects. Terminal half-life is generally variable because of the low solubility of the drug thus prolonging absorption.
Clearance

Apparent clearance (CL/F), single oral 200 mg dose, healthy subjects = 27.7 L/hr.

ToxicitySymptoms of overdose include breathing difficulties, coma, drowsiness, gastrointestinal bleeding, high blood pressure, kidney failure, nausea, sluggishness, stomach pain, and vomiting.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
rs1057910 CYP2C9*1C AllelePoor drug metabolizer, lower dose requirements12893985
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9713
Caco-2 permeable+0.8866
P-glycoprotein substrateNon-substrate0.9287
P-glycoprotein inhibitor INon-inhibitor0.8619
P-glycoprotein inhibitor IINon-inhibitor0.792
Renal organic cation transporterNon-inhibitor0.8582
CYP450 2C9 substrateNon-substrate0.6237
CYP450 2D6 substrateSubstrate0.8919
CYP450 3A4 substrateNon-substrate0.5751
CYP450 1A2 substrateInhibitor0.7805
CYP450 2C9 inhibitorInhibitor0.6172
CYP450 2D6 inhibitorNon-inhibitor0.8594
CYP450 2C19 inhibitorInhibitor0.7169
CYP450 3A4 inhibitorInhibitor0.7959
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.7392
Ames testNon AMES toxic0.7185
CarcinogenicityNon-carcinogens0.7905
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.3719 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9856
hERG inhibition (predictor II)Non-inhibitor0.8419
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Gd searle llc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral100 mg/1
Capsuleoral100 mg
Capsuleoral200 mg/1
Capsuleoral200 mg
Capsuleoral400 mg/1
Capsuleoral50 mg/1
Prices
Unit descriptionCostUnit
Celebrex 400 mg capsule6.78USD capsule
Celebrex 200 mg capsule4.52USD capsule
Celebrex 100 mg capsule2.75USD capsule
Celebrex 50 mg capsule1.26USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada21775761999-10-262014-11-14
Canada22671862002-05-142017-10-14
United States54668231993-11-302013-11-30
United States59729861998-04-142018-04-14
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point158 °CPhysProp
water solubilityVery low water solubility (3.3 mg/L)Not Available
logP3.9Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00503 mg/mLALOGPS
logP3.99ALOGPS
logP4.01ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)10.7ChemAxon
pKa (Strongest Basic)-0.42ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area77.98 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity92.23 m3·mol-1ChemAxon
Polarizability35.2 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

DrugSyn.org

US5466823
General References
  1. Malhotra S, Shafiq N, Pandhi P: COX-2 inhibitors: a CLASS act or Just VIGORously promoted. MedGenMed. 2004 Mar 23;6(1):6. Pubmed
  2. Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, Geis GS: Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA. 2000 Sep 13;284(10):1247-55. Pubmed
  3. Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, Anderson WF, Zauber A, Hawk E, Bertagnolli M: Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med. 2005 Mar 17;352(11):1071-80. Epub 2005 Feb 15. Pubmed
  4. Yelland MJ, Nikles CJ, McNairn N, Del Mar CB, Schluter PJ, Brown RM: Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials. Rheumatology (Oxford). 2007 Jan;46(1):135-40. Epub 2006 Jun 15. Pubmed
  5. Bertagnolli MM, Eagle CJ, Zauber AG, Redston M, Solomon SD, Kim K, Tang J, Rosenstein RB, Wittes J, Corle D, Hess TM, Woloj GM, Boisserie F, Anderson WF, Viner JL, Bagheri D, Burn J, Chung DC, Dewar T, Foley TR, Hoffman N, Macrae F, Pruitt RE, Saltzman JR, Salzberg B, Sylwestrowicz T, Gordon GB, Hawk ET: Celecoxib for the prevention of sporadic colorectal adenomas. N Engl J Med. 2006 Aug 31;355(9):873-84. Pubmed
  6. FDA label
  7. Sandberg M, Yasar U, Stromberg P, Hoog JO, Eliasson E: Oxidation of celecoxib by polymorphic cytochrome P450 2C9 and alcohol dehydrogenase. Br J Clin Pharmacol. 2002 Oct;54(4):423-9. Pubmed
External Links
ATC CodesL01XX33M01AH01
AHFS Codes
  • 28:08.04.08
PDB EntriesNot Available
FDA labelDownload (174 KB)
MSDSDownload (102 KB)
Interactions
Drug Interactions
Drug
AbciximabCelecoxib may increase the anticoagulant activities of Abciximab.
AcenocoumarolCelecoxib may increase the anticoagulant activities of Acenocoumarol.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Celecoxib.
AliskirenCelecoxib may decrease the antihypertensive activities of Aliskiren.
AmikacinCelecoxib may decrease the excretion rate of Amikacin which could result in a lower serum level and potentially a reduction in efficacy.
AmitriptylineAmitriptyline may increase the antiplatelet activities of Celecoxib.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Celecoxib.
ArbekacinCelecoxib may decrease the excretion rate of Arbekacin which could result in a lower serum level and potentially a reduction in efficacy.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Celecoxib.
BalsalazideCelecoxib may increase the nephrotoxic activities of Balsalazide.
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Celecoxib.
CeritinibThe serum concentration of Celecoxib can be increased when it is combined with Ceritinib.
ChlorotrianiseneCelecoxib may increase the thrombogenic activities of Chlorotrianisene.
Citric AcidCelecoxib may increase the anticoagulant activities of Citric Acid.
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Celecoxib.
ColesevelamColesevelam can cause a decrease in the absorption of Celecoxib resulting in a reduced serum concentration and potentially a decrease in efficacy.
CyclosporineCelecoxib may increase the nephrotoxic activities of Cyclosporine.
DabrafenibThe serum concentration of Celecoxib can be decreased when it is combined with Dabrafenib.
DalteparinCelecoxib may increase the anticoagulant activities of Dalteparin.
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Celecoxib.
DeferasiroxThe risk or severity of adverse effects can be increased when Celecoxib is combined with Deferasirox.
DesmopressinThe risk or severity of adverse effects can be increased when Celecoxib is combined with Desmopressin.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Celecoxib.
DicoumarolCelecoxib may increase the anticoagulant activities of Dicoumarol.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Celecoxib.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Celecoxib.
DrospirenoneCelecoxib may increase the hyperkalemic activities of Drospirenone.
Edetic AcidCelecoxib may increase the anticoagulant activities of Edetic Acid.
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Celecoxib.
EnoxaparinCelecoxib may increase the anticoagulant activities of Enoxaparin.
EplerenoneCelecoxib may decrease the antihypertensive activities of Eplerenone.
Ethyl biscoumacetateCelecoxib may increase the anticoagulant activities of Ethyl biscoumacetate.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Celecoxib.
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Celecoxib.
FloxuridineThe metabolism of Celecoxib can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Celecoxib can be decreased when combined with Fluconazole.
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Celecoxib.
FluvoxamineThe metabolism of Fluvoxamine can be decreased when combined with Celecoxib.
Fondaparinux sodiumCelecoxib may increase the anticoagulant activities of Fondaparinux sodium.
FramycetinCelecoxib may decrease the excretion rate of Framycetin which could result in a lower serum level and potentially a reduction in efficacy.
GentamicinCelecoxib may decrease the excretion rate of Gentamicin which could result in a lower serum level and potentially a reduction in efficacy.
HaloperidolThe risk or severity of adverse effects can be increased when Celecoxib is combined with Haloperidol.
HeparinCelecoxib may increase the anticoagulant activities of Heparin.
HomoharringtonineThe risk or severity of adverse effects can be increased when Celecoxib is combined with Homoharringtonine.
HydralazineCelecoxib may decrease the antihypertensive activities of Hydralazine.
IcosapentThe risk or severity of adverse effects can be increased when Celecoxib is combined with Icosapent.
InfliximabThe risk or severity of adverse effects can be increased when Infliximab is combined with Celecoxib.
KanamycinCelecoxib may decrease the excretion rate of Kanamycin which could result in a lower serum level and potentially a reduction in efficacy.
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Celecoxib.
LithiumThe serum concentration of Lithium can be increased when it is combined with Celecoxib.
LumacaftorThe serum concentration of Celecoxib can be decreased when it is combined with Lumacaftor.
MecamylamineThe risk or severity of adverse effects can be increased when Celecoxib is combined with Mecamylamine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Celecoxib.
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Celecoxib.
MifepristoneThe serum concentration of Celecoxib can be increased when it is combined with Mifepristone.
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Celecoxib.
NadololCelecoxib may decrease the antihypertensive activities of Nadolol.
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Celecoxib.
NeomycinCelecoxib may decrease the excretion rate of Neomycin which could result in a lower serum level and potentially a reduction in efficacy.
NetilmicinCelecoxib may decrease the excretion rate of Netilmicin which could result in a lower serum level and potentially a reduction in efficacy.
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Celecoxib.
PamidronateThe risk or severity of adverse effects can be increased when Celecoxib is combined with Pamidronate.
ParoxetineParoxetine may increase the antiplatelet activities of Celecoxib.
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Celecoxib.
PhenindioneCelecoxib may increase the anticoagulant activities of Phenindione.
PhenprocoumonCelecoxib may increase the anticoagulant activities of Phenprocoumon.
PhenytoinThe metabolism of Celecoxib can be increased when combined with Phenytoin.
PorfimerCelecoxib may increase the photosensitizing activities of Porfimer.
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Celecoxib.
PrilocaineThe risk or severity of adverse effects can be increased when Celecoxib is combined with Prilocaine.
ProbenecidThe serum concentration of Celecoxib can be increased when it is combined with Probenecid.
PropafenoneThe serum concentration of Celecoxib can be increased when it is combined with Propafenone.
RibostamycinCelecoxib may decrease the excretion rate of Ribostamycin which could result in a lower serum level and potentially a reduction in efficacy.
SecobarbitalThe metabolism of Celecoxib can be increased when combined with Secobarbital.
Sodium NitriteThe risk or severity of adverse effects can be increased when Celecoxib is combined with Sodium Nitrite.
SparfloxacinCelecoxib may increase the neuroexcitatory activities of Sparfloxacin.
SpectinomycinCelecoxib may decrease the excretion rate of Spectinomycin which could result in a lower serum level and potentially a reduction in efficacy.
StreptomycinCelecoxib may decrease the excretion rate of Streptomycin which could result in a lower serum level and potentially a reduction in efficacy.
SulfisoxazoleThe metabolism of Celecoxib can be decreased when combined with Sulfisoxazole.
SulodexideCelecoxib may increase the anticoagulant activities of Sulodexide.
TacrolimusCelecoxib may increase the nephrotoxic activities of Tacrolimus.
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Celecoxib.
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Celecoxib resulting in a loss in efficacy.
TenofovirThe risk or severity of adverse effects can be increased when Celecoxib is combined with Tenofovir.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Celecoxib.
TobramycinCelecoxib may decrease the excretion rate of Tobramycin which could result in a lower serum level and potentially a reduction in efficacy.
TorasemideThe metabolism of Torasemide can be decreased when combined with Celecoxib.
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Celecoxib.
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Celecoxib.
TriamtereneCelecoxib may decrease the antihypertensive activities of Triamterene.
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Celecoxib.
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Celecoxib.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Celecoxib.
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Celecoxib.
VerteporfinCelecoxib may increase the photosensitizing activities of Verteporfin.
WarfarinCelecoxib may increase the anticoagulant activities of Warfarin.
Food Interactions
  • Take without regard to meals.
  • Taking this product with a high-fat meal will delay the Cmax, but total absorption will be increased by 10 to 20%.

Targets

1. Prostaglandin G/H synthase 2

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Prostaglandin G/H synthase 2 P35354 Details

References:

  1. Sigthorsson G, Simpson RJ, Walley M, Anthony A, Foster R, Hotz-Behoftsitz C, Palizban A, Pombo J, Watts J, Morham SG, Bjarnason I: COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. Gastroenterology. 2002 Jun;122(7):1913-23. Pubmed
  2. Scheiman JM: Outcomes studies of the gastrointestinal safety of cyclooxygenase-2 inhibitors. Cleve Clin J Med. 2002;69 Suppl 1:SI40-6. Pubmed
  3. Reddy BS, Rao CV: Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors. J Environ Pathol Toxicol Oncol. 2002;21(2):155-64. Pubmed
  4. Ahmad SR, Kortepeter C, Brinker A, Chen M, Beitz J: Renal failure associated with the use of celecoxib and rofecoxib. Drug Saf. 2002;25(7):537-44. Pubmed
  5. Lu S, Zhang X, Badawi AF, El-Sohemy A, Archer MC: Cyclooxygenase-2 inhibitor celecoxib inhibits promotion of mammary tumorigenesis in rats fed a high fat diet rich in n-6 polyunsaturated fatty acids. Cancer Lett. 2002 Oct 8;184(1):7-12. Pubmed
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed

2. 3-phosphoinositide-dependent protein kinase 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
3-phosphoinositide-dependent protein kinase 1 O15530 Details

References:

  1. Kulp SK, Yang YT, Hung CC, Chen KF, Lai JP, Tseng PH, Fowble JW, Ward PJ, Chen CS: 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells. Cancer Res. 2004 Feb 15;64(4):1444-51. Pubmed
  2. Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW, Shaw YJ, Kulp SK, Chen CS: From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 Jun 15;64(12):4309-18. Pubmed
  3. Tong Z, Wu X, Ovcharenko D, Zhu J, Chen CS, Kehrer JP: Neutrophil gelatinase-associated lipocalin as a survival factor. Biochem J. 2005 Oct 15;391(Pt 2):441-8. Pubmed
  4. Li J, Zhu J, Melvin WS, Bekaii-Saab TS, Chen CS, Muscarella P: A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth. J Gastrointest Surg. 2006 Feb;10(2):207-14. Pubmed
  5. Tseng PH, Wang YC, Weng SC, Weng JR, Chen CS, Brueggemeier RW, Shapiro CL, Chen CY, Dunn SE, Pollak M, Chen CS: Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor. Mol Pharmacol. 2006 Nov;70(5):1534-41. Epub 2006 Aug 3. Pubmed

Enzymes

1. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Davies NM, McLachlan AJ, Day RO, Williams KM: Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2000 Mar;38(3):225-42. Pubmed
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  3. Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. Pubmed
  4. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  5. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  6. Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M: Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):368-74. Pubmed
  7. Rodrigues AD: Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug Metab Dispos. 2005 Nov;33(11):1567-75. Epub 2005 Aug 23. Pubmed

2. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Werner U, Werner D, Rau T, Fromm MF, Hinz B, Brune K: Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans. Clin Pharmacol Ther. 2003 Aug;74(2):130-7. Pubmed
  2. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Carriers

1. Serum albumin

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Serum albumin P02768 Details

References:

  1. FDA label

2. Alpha-1-acid glycoprotein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Alpha-1-acid glycoprotein 1 P02763 Details

References:

  1. FDA label

Transporters

1. Multidrug resistance-associated protein 4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance-associated protein 4 O15439 Details

References:

  1. Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on October 08, 2013 14:22