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Identification
NameLidocaine
Accession NumberDB00281  (APRD00479, DB05291)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. [PubChem]

Structure
Thumb
Synonyms
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
alpha-diethylamino-2,6-dimethylacetanilide
Lignocaine
α-diethylamino-2,6-dimethylacetanilide
External Identifiers
  • LSM-3165
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
2% Lidocaine Hydrochloride Injection USPsolution20 mgintravenousHospira Healthcare Corporation1987-12-31Not applicableCanada
AgoneazekittopicalAlvix Laboratories, LLC2016-01-12Not applicableUs
Aktengel35 mg/mLophthalmicAkorn, Inc.2008-10-08Not applicableUs
Amniocentesis Tray 1%liquid1 %block/infiltration; subcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Anestheticgel5 g/100gtopicalCosmoceutical Research Center Inc2012-02-18Not applicableUs
Antecubital Cent Venous Catheterization Kitliquid1 %epiduralArrow International Inc.1991-12-311999-07-02Canada
Arthrogram Tray 1%liquid1 %intra-articularAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Atelocollagen Implantimplant.3 %intradermalKoken Co. Ltd.1989-12-312005-08-25Canada
Basic Biopsy Tray 1%liquid1 %block/infiltration; subcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Bio-scriptives Lidum Topical Analgesiccream2.8 g/56gtopicalBio Scriptives, Inc.2012-03-07Not applicableUs
Burncare Sprayspray2.4 %topicalAvacare, Division Of Jeunique International Inc.1985-12-311997-11-10Canada
Cathejell Jelly 2%gel20 mgtopicalPharmazeutische Fabrik Montavit Ges M.B.H.2012-05-25Not applicableCanada
Derma Numbspray40 mg/gtopicalAtlas Tat Inc.2012-07-15Not applicableUs
Laryng O Jet Kitliquid40 mgintratrachealInternational Medication Systems Ltd.1978-12-311997-08-15Canada
Lidocainepatch700 mg/1cutaneousDIRECT RX2016-03-03Not applicableUs
Lidocainepatch700 mg/1cutaneousQualitest Pharmaceuticals2014-05-02Not applicableUs
Lidocaineinjection, solution20 mg/mLintravenousAPP Pharmaceuticals, LLC2000-09-05Not applicableUs
Lidocaineinjection, solution20 mg/mLintravenousCardinal Health2000-09-05Not applicableUs
Lidocainepatch700 mg/1cutaneousCardinal Health2014-05-02Not applicableUs
Lidocaine HCl Inj 1%liquid10 mgblock/infiltration; epiduralInternational Medication Systems Ltd.1971-12-311997-08-15Canada
Lidocaine HCl Inj 10mg/ml USPliquid10 mgblock/infiltrationElkins Sinn Inc.1995-12-312004-02-16Canada
Lidocaine HCl Inj 20mg/mlliquid20 mgintravenousInternational Medication Systems Ltd.1982-12-311997-08-15Canada
Lidocaine HCl Injectionsolution20 mgblock/infiltrationAlveda Pharmaceuticals Inc2015-08-19Not applicableCanada
Lidocaine HCl Injectionsolution10 mgblock/infiltrationAlveda Pharmaceuticals Inc2015-06-29Not applicableCanada
Lidocaine HCl Injection USP 1% (50 Mg/5ml)solution10 mgblock/infiltration4410602 Canada IncNot applicableNot applicableCanada
Lidocaine HCl Injection USP 1% (50mg/5ml)solution10 mgblock/infiltrationValesco Pharmaceuticals Inc2010-11-17Not applicableCanada
Lidocaine HCl Injection With Preservativesolution10 mgblock/infiltrationAlveda Pharmaceuticals Inc2015-11-25Not applicableCanada
Lidocaine HCl Injection With Preservativesolution20 mgblock/infiltrationAlveda Pharmaceuticals Inc2016-01-12Not applicableCanada
Lidocaine HCl Jelly 2%jelly20 mgtopicalInternational Medication Systems Ltd.1971-12-311997-08-15Canada
Lidocaine Hydrochloridegel40 mg/gtopicalGensco Laboratories, LLC2009-06-30Not applicableUs
Lidocaine Hydrochloride and Dextroseinjection, solution4 mg/mLintravenousBaxter Healthcare Corporation1981-04-22Not applicableUs
Lidocaine Hydrochloride and Dextroseinjection, solution800 mg/100mLintravenousHospira, Inc.1980-12-192016-03-03Us
Lidocaine Hydrochloride and Dextroseinjection, solution400 mg/100mLintravenousHospira, Inc.1980-12-192016-03-03Us
Lidocaine Hydrochloride and Dextroseinjection, solution8 mg/mLintravenousBaxter Healthcare Corporation1981-04-22Not applicableUs
Lidocaine Hydrochloride Injectionsolution10 mgblock/infiltrationSterimax IncNot applicableNot applicableCanada
Lidocaine Hydrochloride Injection USPsolution10 mgblock/infiltrationMylan Pharmaceuticals Ulc1994-12-31Not applicableCanada
Lidocaine Hydrochloride Injection USPliquid20 mgblock/infiltrationMylan Pharmaceuticals Ulc1994-12-31Not applicableCanada
Lidocaine Hydrochloride Injection USP 0.5%solution5 mgblock/infiltrationHospira Healthcare CorporationNot applicableNot applicableCanada
Lidocaine Hydrochloride Injection USP 1%solution10 mgblock/infiltrationHospira Healthcare Corporation1990-12-31Not applicableCanada
Lidocaine Hydrochloride Injection USP 2%liquid2 %block/infiltrationAlveda Pharmaceuticals Inc2009-01-09Not applicableCanada
Lidocaine Hydrochloride Injection USP 2%solution20 mgblock/infiltrationHospira Healthcare Corporation1994-12-31Not applicableCanada
Lidocaine Hydrochloride Injection, USP 1%solution10 mgblock/infiltrationAlveda Pharmaceuticals Inc2008-04-23Not applicableCanada
Lidocaine Ont 5% Graham Flavoredointment5 gGraham Chemical Corp.1986-10-311999-08-10Canada
Lidodan 4% Topical Solutionsolution4 %topicalOdan Laboratories Ltd2014-02-20Not applicableCanada
Lidodan Endotracheal Non-aerosol Sprayliquid10 mgtopicalOdan Laboratories Ltd1998-07-22Not applicableCanada
Lidodan Jelly 2%(single Use Syringe)jelly2 %topicalOdan Laboratories Ltd2002-06-01Not applicableCanada
Lidodan Ointment 5%ointment5 %topicalOdan Laboratories Ltd1994-12-31Not applicableCanada
Lidodermpatch700 mg/1cutaneousUnit Dose Services1999-03-20Not applicableUs
Lidodermpatch700 mg/1cutaneousLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-01Not applicableUs
Lidodermpatch700 mg/1cutaneousSTAT Rx USA LLC1999-03-20Not applicableUs
Lidodermpatch700 mg/1cutaneousDispensing Solutions, Inc.1999-03-20Not applicableUs
Lidodermpatch700 mg/1cutaneousSTAT Rx USA LLC2010-02-01Not applicableUs
Lidodermpatch700 mg/1cutaneousbryant ranch prepack1999-03-20Not applicableUs
Lidodermpatch700 mg/1cutaneousAidarex Pharmaceuticals LLC1999-03-20Not applicableUs
Lidodermpatch700 mg/1cutaneousEndo Pharmaceuticals Inc.1999-03-20Not applicableUs
Lidodermpatch700 mg/1cutaneousH.J. Harkins Company, Inc.1999-03-20Not applicableUs
Lidodermpatch700 mg/12hcutaneousRebel Distributors Corp.2010-02-01Not applicableUs
Lidodermpatch700 mg/1cutaneousPhysicians Total Care, Inc.2003-05-05Not applicableUs
Lidoderm 5liquid700 mg/1000mgcutaneousSt Marys Medical Park Pharmacy2010-12-21Not applicableUs
Lumbar Puncture Tray 1%liquid1 %block/infiltration; subcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Lumbar Puncture Tray 1% Pediatric/infantliquid1 %subcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Myelogram Tray 1%liquid1 %block/infiltration; intraspinal; subcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Percutaneous Sheath Introducer Kit Hl-09883liquid1 %intravenousArrow International Inc.1989-12-311999-07-02Canada
Preattached Lta Kitsolution40 mgtopicalHospira Healthcare Corporation1979-12-312016-02-25Canada
Spinal Anesthesia Tray 1%kit1 %block/infiltrationBaxter Corporation1994-12-312001-07-31Canada
Thoracentesis Tray 1%liquid1 %intrathoracic; subcutaneousAllegiance Healthcare Corporation1992-12-312000-07-31Canada
Xylocaineinjection, solution20 mg/mLinfiltration; perineuralCardinal Health2010-08-12Not applicableUs
Xylocainesolution40 mg/mLtopicalAPP Pharmaceuticals, LLC2009-11-11Not applicableUs
Xylocaineinjection, solution10 mg/mLinfiltration; perineuralGeneral Injectables & Vaccines, Inc2011-09-26Not applicableUs
Xylocaineinjection, solution5 mg/mLinfiltration; perineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocainejelly.5 mg/18mLtopicalOak Pharmaceuticals, Inc. (Subsidiary of Akorn, Inc.)2012-07-01Not applicableUs
Xylocaineinjection, solution20 mg/mLinfiltration; perineuralPhysicians Total Care, Inc.1993-11-09Not applicableUs
Xylocainejelly20 mg/mLtopicalAPP Pharmaceuticals, LLC2010-09-27Not applicableUs
Xylocaineinjection, solution10 mg/mLinfiltration; perineuralCardinal Health2010-08-12Not applicableUs
Xylocaineinjection, solution10 mg/mLinfiltration; perineuralPhysicians Total Care, Inc.1995-05-15Not applicableUs
Xylocaineinjection, solution10 mg/mLinfiltrationREMEDYREPACK INC.2015-05-18Not applicableUs
Xylocaineinjection, solution10 mg/mLinfiltration; perineuralCardinal Health2010-08-12Not applicableUs
Xylocaineinjection, solution20 mg/mLinfiltration; perineuralCardinal Health2010-08-12Not applicableUs
Xylocaineinjection10 mg/mLinfiltrationRebel Distributors Corp1948-11-19Not applicableUs
Xylocaineinjection, solution20 mg/mLinfiltration; perineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocaineinjection, solution5 mg/mLinfiltration; perineuralGeneral Injectables & Vaccines, Inc2011-09-21Not applicableUs
Xylocainejelly20 mg/mLtopicalCardinal Health2012-07-16Not applicableUs
Xylocaineinjection, solution20 mg/mLintravenousAPP Pharmaceuticals, LLC2009-11-11Not applicableUs
Xylocaineinjection, solution20 mg/mLinfiltration; perineuralGeneral Injectables & Vaccines, Inc2011-11-09Not applicableUs
Xylocaineinjection, solution10 mg/mLinfiltration; perineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocaine 0.5%solution5 mgblock/infiltrationAstrazeneca Canada Inc2012-10-29Not applicableCanada
Xylocaine 0.5%liquid5 mgblock/infiltrationAstrazeneca Canada Inc1954-12-312015-05-31Canada
Xylocaine 1.5%solution15 mgepiduralAstrazeneca Canada Inc1954-12-312005-08-02Canada
Xylocaine 1%liquid10 mgblock/infiltrationAstrazeneca Canada Inc1954-12-31Not applicableCanada
Xylocaine 1%liquid10 mgblock/infiltrationAstrazeneca Canada Inc2009-01-23Not applicableCanada
Xylocaine 2%liquid20 mgblock/infiltrationAstrazeneca Canada Inc1997-03-192003-07-24Canada
Xylocaine 2%liquid20 mgblock/infiltrationAstrazeneca Canada Inc1954-12-31Not applicableCanada
Xylocaine 2%liquid20 mgblock/infiltrationAstrazeneca Canada Inc2009-01-29Not applicableCanada
Xylocaine 2% Epiduralsolution20 mgepiduralAstrazeneca Canada Inc1965-12-312005-08-02Canada
Xylocaine 2% Jellyjelly20 mgurethralAstrazeneca Canada Inc1978-12-31Not applicableCanada
Xylocaine 5% Spinalliquid50 mgsubarachnoidalAstrazeneca Canada Inc1984-12-312002-10-18Canada
Xylocaine Co2 Injsolution17.3 mgblock/infiltration; epiduralAstrazeneca Canada Inc1973-12-312004-09-01Canada
Xylocaine Endotrachealsolution100 mgoralAstrazeneca Canada Inc1993-12-31Not applicableCanada
Xylocaine Jelly 2%jelly20 mgtopicalAstrazeneca Canada Inc1951-12-31Not applicableCanada
Xylocaine Mpfinjection, solution20 mg/mLepidural; infiltration; intracaudal; perineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocaine Mpfinjection, solution15 mg/mLepidural; infiltration; intracaudal; perineuralFresenius Kabi USA, LLC2011-07-18Not applicableUs
Xylocaine Mpfinjection, solution10 mg/mLepidural; infiltration; intracaudal; perineuralCardinal Health2010-08-12Not applicableUs
Xylocaine Mpfinjection, solution10 mg/mLepidural; infiltration; intracaudal; perineuralFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocaine Mpfliquid1 %percutaneousAstra Pharmaceuticals L.P.Not applicableNot applicableCanada
Xylocaine Mpfinjection, solution20 mg/mLepidural; infiltration; intracaudal; perineuralCardinal Health2010-08-12Not applicableUs
Xylocaine Mpfinjection, solution10 mg/mLepidural; infiltration; intracaudal; perineuralCardinal Health2010-08-12Not applicableUs
Xylocaine Mpfinjection, solution5 mg/mLinfiltrationFresenius Kabi USA, LLC2010-08-12Not applicableUs
Xylocaine Mpfinjection, solution20 mg/mLepidural; infiltration; intracaudal; perineuralCardinal Health2010-08-12Not applicableUs
Xylocaine Mpfinjection, solution20 mg/mLepidural; infiltration; intracaudal; perineuralFresenius Kabi USA, LLC2011-07-18Not applicableUs
Xylocaine Mpf 1%liquid1 %block/infiltrationAstrazeneca L.P.1988-12-312001-10-12Canada
Xylocaine Ointment 5%ointment5 %topicalAstrazeneca Canada Inc1954-12-31Not applicableCanada
Xylocaine Topical 4%spray40 mgtopicalAstrazeneca Canada Inc1962-12-312015-04-30Canada
Xylocaine Topical 5%liquid50 mgtopicalAstrazeneca Canada Inc1958-12-312003-01-24Canada
Xylocaine Viscous 2%liquid20 mgoral; topicalAstrazeneca Canada Inc1954-12-31Not applicableCanada
Xylocaine-mpfsolution40 mg/mLretrobulbar; topicalAPP Pharmaceuticals, LLC2009-11-11Not applicableUs
Xylocaine-mpf, 2%liquid20 mgintracaudal; epiduralAstra Pharmaceuticals L.P.Not applicableNot applicableCanada
Xylocard Injliquid100 mgintravenousAstrazeneca Canada Inc1974-12-31Not applicableCanada
Xylocard One Gm Additive Unit 20% Injliquid200 mgintravenousAstra Pharma Inc.1974-12-311999-07-29Canada
Zingopowder.5 mg/1intradermalMedline Industries, Inc.2014-02-21Not applicableUs
Zingopowder.5 mg/1intradermalPowder Pharmaceuticals Inc.2015-01-05Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Accucaineinjection, solution10 mg/mLinfiltrationAsclemed Usa, Inc.1972-09-28Not applicableUs
Anestaconjelly20 mg/mLtopicalHi Tech Pharmacal Co., Inc.2001-11-05Not applicableUs
Glydojelly20 mg/mLtopicalSagent Pharmaceuticals2014-09-15Not applicableUs
Laryng-O-jetsolution40 mg/mLtopicalAmphastar Pharmaceuticals, Inc.1980-03-06Not applicableUs
Lidocaineointment50 mg/gtopicalAidarex Pharmaceuticals LLC1972-06-30Not applicableUs
Lidocaineointment50 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.2013-03-25Not applicableUs
Lidocainejelly20 mg/mLtopicalActavis Pharma, Inc.2015-06-15Not applicableUs
Lidocaineointment50 mg/gtopicalPharmaceutica North America, Inc2015-08-13Not applicableUs
Lidocaineointment35.44 g/gtopicalSolubiomix2016-01-28Not applicableUs
Lidocainepatch140 mg/1cutaneousMylan Pharmaceuticals Inc.2015-08-07Not applicableUs
Lidocainejelly20 mg/mLtopicalAkorn, Inc.2003-08-01Not applicableUs
Lidocaineointment50 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1981-08-17Not applicableUs
Lidocainejelly20 mg/mLtopicalPhysicians Total Care, Inc.2000-06-01Not applicableUs
Lidocainepatch700 mg/1cutaneousClinical Solutions Wholesale2013-09-15Not applicableUs
Lidocaineointment5 g/100gtopicalSeptodont, Inc.2015-05-20Not applicableUs
Lidocainejelly20 mg/mLtopicalAkorn, Inc.2003-08-01Not applicableUs
Lidocainepatch700 mg/1cutaneousDIRECT RX2014-01-01Not applicableUs
Lidocaineinjection, solution20 mg/mLepidural; infiltrationGeneral Injectables & Vaccines, Inc2010-04-01Not applicableUs
Lidocaineointment5 g/100gtopicalNovocol Inc.2011-10-01Not applicableUs
Lidocaineointment50 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1972-06-30Not applicableUs
Lidocaineointment50 mg/gtopicalGemini Laboratories, Inc.2016-03-11Not applicableUs
Lidocaineointment50 mg/gtopicalRebel Distributors Corp1972-06-30Not applicableUs
Lidocainepatch700 mg/1cutaneousUnit Dose Services2013-09-15Not applicableUs
Lidocainepatch700 mg/1cutaneousLake Erie Medical DBA Quality Care Products LLC2013-09-15Not applicableUs
Lidocaineinjection, solution10 mg/mLinfiltrationREMEDYREPACK INC.2015-06-22Not applicableUs
Lidocainepatch700 mg/1cutaneousPure Tek Corporation2016-02-29Not applicableUs
Lidocaineinjection, solution10 mg/mLinfiltration; perineuralCardinal Health2010-05-27Not applicableUs
Lidocainepatch700 mg/1cutaneousbryant ranch prepack2013-09-15Not applicableUs
Lidocaineointment5 g/100gtopicalHi Tech Pharmacal Co., Inc.2012-03-12Not applicableUs
Lidocaineinjection, solution20 mg/mLinfiltration; perineuralAPP Pharmaceuticals, LLC2010-05-27Not applicableUs
Lidocaineointment50 mg/gtopicalAv Kare, Inc.2015-09-21Not applicableUs
Lidocaineointment50 mg/gtopicalAmneal Pharmaceuticals of New York, LLC2015-08-10Not applicableUs
Lidocainepatch700 mg/1cutaneousActavis Pharma, Inc.2014-06-26Not applicableUs
Lidocainepatch700 mg/1cutaneousActavis Pharma, Inc.2013-09-15Not applicableUs
Lidocaineinjection, solution10 mg/mLinfiltration; perineuralUs Med Source, Llc2014-07-02Not applicableUs
Lidocaineointment50 mg/gtopicalTeligent Pharma, Inc.2016-02-01Not applicableUs
Lidocainejelly20 mg/mLtopicalAkorn, Inc.2013-08-01Not applicableUs
Lidocaineinjection, solution10 mg/mLinfiltration; perineuralAPP Pharmaceuticals, LLC2010-05-27Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationHospira, Inc.1984-07-31Not applicableUs
Lidocaine Hydrochlorideinjection, solution5 mg/mLinfiltrationGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltration; intracaudal; perineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLintravenousCardinal Health2010-11-29Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoropharyngealClinical Solutions Wholesale2007-02-27Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoropharyngealMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2007-02-27Not applicableUs
Lidocaine Hydrochlorideinjection20 mg/mLintravenousInternational Medication Systems, Limited2001-06-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLintravenousREMEDYREPACK INC.2013-07-16Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLepidural; infiltration; intracaudal; perineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalCardinal Health1979-08-07Not applicableUs
Lidocaine Hydrochloridesolution40 mg/mLtopicalMorton Grove Pharmaceuticals, Inc.1982-11-18Not applicableUs
Lidocaine Hydrochlorideinjection10 mg/mLinfiltration; intravenousMylan Institutional LLC2010-09-12Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltrationHospira, Inc.1984-05-17Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalHi Tech Pharmacal Co., Inc.1995-07-10Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoropharyngealA S Medication Solutions Llc2007-02-27Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochloridesolution20 mg/100mLoropharyngealDIRECT RX2014-01-01Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalPreferred Pharmaceuticals, Inc.2012-04-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLintravenousHospira, Inc.1972-10-31Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationHospira, Inc.1984-07-31Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLintravenousGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLintravenousCardinal Health2010-11-29Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalInternational Medication Systems, Limited1979-08-07Not applicableUs
Lidocaine Hydrochlorideinjection20 mg/mLparenteralAmphastar Pharmaceuticals, Inc.2001-06-01Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLintravenousGeneral Injectables & Vaccine, Inc2010-03-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLepidural; infiltration; intracaudal; perineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine Hydrochlorideinjection5 mg/mLinfiltration; intravenousMylan Institutional LLC2010-09-12Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLintravenousHospira, Inc.1972-10-31Not applicableUs
Lidocaine Hydrochlorideinjection, solution5 mg/mLinfiltrationHospira, Inc.1984-07-31Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoralLLC Federal Solutions2013-06-24Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoropharyngealUnit Dose Services2007-02-27Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationPhysicians Total Care, Inc.1994-06-28Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLintravenousCardinal Health2010-11-29Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalInternational Medication Systems, Limited1979-08-07Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalCardinal Health1995-07-10Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalAmphastar Pharmaceuticals, Inc.1979-08-07Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalSTAT RX LLC USA1995-07-10Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1995-07-10Not applicableUs
Lidocaine Hydrochloridesolution40 mg/mLtopicalIGI Labs, Inc.2014-03-18Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLintravenousGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLepidural; infiltration; intracaudal; perineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine Hydrochlorideinjection, solution40 mg/mLretrobulbar; topicalCardinal Health2010-03-24Not applicableUs
Lidocaine Hydrochlorideinjection10 mg/mLepidural; infiltration; intracaudalMylan Institutional LLC2010-10-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution15 mg/mLepidural; infiltrationHospira, Inc.1972-09-28Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltrationHospira, Inc.1984-05-17Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalGeneral Injectables & Vaccines, Inc2012-08-28Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationPhysicians Total Care, Inc.1994-08-23Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLintravenousMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2010-05-03Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalInternational Medication Systems, Limited1979-08-07Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalAmphastar Pharmaceuticals, Inc.1979-08-07Not applicableUs
Lidocaine Hydrochloridesolution40 mg/mLtopicalQualitest Pharmaceuticals2007-02-27Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationREMEDYREPACK INC.2013-09-27Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltration; intracaudal; perineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalCardinal Health1979-08-07Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationUs Med Source, Llc2014-06-12Not applicableUs
Lidocaine Hydrochlorideinjection5 mg/mLinfiltration; intravenousMylan Institutional LLC2010-10-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationHospira, Inc.1972-09-28Not applicableUs
Lidocaine Hydrochlorideinjection, solution15 mg/mLepidural; infiltrationHospira, Inc.1972-09-28Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalRebel Distributors Corp1995-07-10Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalUnit Dose Services1995-07-10Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalGeneral Injectables & Vaccines, Inc2012-05-30Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalPhysicians Total Care, Inc.2003-05-08Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalInternational Medication Systems, Limited1979-08-07Not applicableUs
Lidocaine Hydrochlorideinjection, solution5 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalAmphastar Pharmaceuticals, Inc.1979-08-07Not applicableUs
Lidocaine Hydrochloridesolution40 mg/mLtopicalRoxane Laboratories,Inc.1985-04-03Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoropharyngealQualitest Pharmaceuticals2007-02-27Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLintravenousREMEDYREPACK INC.2013-06-12Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationREMEDYREPACK INC.2013-11-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLintravenousGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltration; intracaudal; perineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalCardinal Health1979-08-07Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationUs Med Source, Llc2014-05-29Not applicableUs
Lidocaine Hydrochlorideinjection10 mg/mLinfiltration; intravenousMylan Institutional LLC2010-09-12Not applicableUs
Lidocaine Hydrochlorideinjection, solution40 mg/mLretrobulbar; topicalHospira, Inc.1984-05-16Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLepidural; infiltrationHospira, Inc.2009-11-17Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoral; topicalAtlantic Biologicals Corps1995-07-10Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalGeneral Injectables & Vaccines, Inc2012-06-12Not applicableUs
Lidocaine Hydrochloridesolution40 mg/mLtopicalA S Medication Solutions Llc2007-02-27Not applicableUs
Lidocaine Hydrochlorideinjection, solution40 mg/mLretrobulbar; topicalCardinal Health2010-03-24Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection20 mg/mLinfiltration; intravenousAGILA SPECIALTIES PRIVATE LIMITED2014-04-12Not applicableUs
Lidocaine Hydrochlorideinjection, solution5 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalAmphastar Pharmaceuticals, Inc.1979-08-07Not applicableUs
Lidocaine Hydrochlorideinjection, solution5 mg/mLinfiltration; intravenousHospira, Inc.1984-05-17Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLoropharyngealREMEDYREPACK INC.2013-06-10Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltration; intracaudal; perineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLepidural; infiltrationCardinal Health2009-11-17Not applicableUs
Lidocaine Hydrochloridesolution20 mg/mLtopicalMorton Grove Pharmaceuticals, Inc.1982-11-18Not applicableUs
Lidocaine Hydrochloridesolution40 mg/mLtopicalInternational Medication Systems, Limited2012-06-19Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationREMEDYREPACK INC.2013-06-12Not applicableUs
Lidocaine Hydrochloridesolution40 mg/mLtopicalREMEDYREPACK INC.2013-09-25Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLepidural; infiltrationGeneral Injectables & Vaccines2010-04-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltration; intracaudal; perineuralAuro Medics Pharma Llc2013-03-14Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalCardinal Health1979-08-07Not applicableUs
Lidocaine Hydrochlorideinjection10 mg/mLinfiltration; intravenousMylan Institutional LLC2010-09-12Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLepidural; infiltrationHospira, Inc.1984-05-16Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLintravenousHospira, Inc.1998-09-28Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalHi Tech Pharmacal Co., Inc.2011-03-23Not applicableUs
Lidocaine Hydrochloridejelly20 mg/mLtopicalGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationA S Medication Solutions Llc2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLepidural; infiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution20 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLinfiltrationCardinal Health2010-03-30Not applicableUs
Lidocaine Hydrochlorideinjection, solution10 mg/mLintravenousHospira, Inc.1998-09-28Not applicableUs
Lidocaine Viscoussolution20 mg/mLoral; topicalRoxane Laboratories,Inc1985-04-26Not applicableUs
Lidocaine Viscoussolution20 mg/mLoral; topicalCardinal Health1985-04-26Not applicableUs
Lidocaine Viscoussolution20 mg/mLoral; topicalDIRECT RX2014-01-01Not applicableUs
Lidocaine Viscoussolution20 mg/mLoral; topicalRoxane Laboratories,Inc1985-04-26Not applicableUs
Lidocaine Viscoussolution20 mg/mLoral; topicalRoxane Laboratories,Inc1985-04-26Not applicableUs
Medicated Dna Collection Kitsolution20 mg/mLoral; topicalTrue Fit Rx Llc2015-12-04Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
After Sun Burn Relief Lidocaine Continuous Spraysolution1 %topicalPrime Enterprises Inc2010-04-08Not applicableCanada
After Sun Gelgel1 %topicalWatkins IncorporatedNot applicableNot applicableCanada
After Sun Soothing Sprayliquid; spray0.5 %topicalKinesys Pharmaceutical Inc1995-03-17Not applicableCanada
Afterburngel2.5 g/100gtopicalTender Corporation2011-04-12Not applicableUs
Afterburngel0.5 %topicalTender Corporation1995-12-31Not applicableCanada
Aftersun Cooling Cvsgel.5 g/100mLtopicalCVS2014-11-11Not applicableUs
Alocanegel4 %topicalQuest Products IncNot applicableNot applicableCanada
Alocaneointment4 g/100mLtopicalQuest Products, Inc.2013-06-01Not applicableUs
Aloegel.5 g/100mLtopicalKmart Corporation2012-01-15Not applicableUs
Aloe Gel Pain Reliever Well At Walgreensgel.5 g/100gtopicalWalgreens2013-03-15Not applicableUs
Aloe Ice Sunburn Relief Jellygel2 g/100mLtopicalAloe Care International, Llc2014-02-24Not applicableUs
Aloe Ice Sunburn Relief Jellygel2 %topicalAloe Care International LlcNot applicableNot applicableCanada
Anecreamcream4 %topicalFocus Health GroupNot applicableNot applicableCanada
Anecreamcream4 g/100gtopicalFocus Health Group2007-06-01Not applicableUs
Anecream 5cream5 g/100gtopicalFocus Health Group2011-12-20Not applicableUs
Anestacream5 g/100gtopicalHumex,Inc.2016-01-01Not applicableUs
Anestacream5 g/100gtopicalHumex,Inc.2016-01-01Not applicableUs
Anorectal Equatecream5 g/100mLtopicalWalmart2016-04-16Not applicableUs
Aspercremepatch246 mg/1topicalLead Chemical Co. Ltd.2016-02-16Not applicableUs
Aspercreme With Lidocaineointment246 mg/1topicalChattem, Inc.2016-02-01Not applicableUs
Aspercreme With Lidocaine Pain Relieving Cremelotion4 g/100gtopicalChattem, Inc.2014-12-01Not applicableUs
Assuredgel2.5 g/100gtopicalAnhui Nhu Pharmaceutical Co., Ltd.2015-12-26Not applicableUs
Assuredgel2.5 g/100gtopicalZhejiang Jingwei Pharmaceutical Co., Ltd.2014-10-30Not applicableUs
Assuredgel2.5 g/100gtopicalAnhui Nhu Pharmaceutical Co., Ltd.2015-01-28Not applicableUs
Assured Bikini Smooth Creamcream2 g/100gtopicalZhejiang Jingwei Pharmaceutical Co., Ltd.2015-10-30Not applicableUs
Australian Gold Aloe Freeze Gel With Lidocainegel4.1 mg/mLtopicalPrime Enterprises, Inc.2014-06-09Not applicableUs
Banana Boat Soothacaine Spray Gelgel0.7 %topicalPlaytex Ltd.2005-02-152009-08-06Canada
Band-aid Brand Antiseptic Washliquid2 %topicalJohnson & Johnson Inc2002-03-01Not applicableCanada
Bed Bug Instant Bite Reliefgel40 mg/gtopicalP.F. Harris Mfg. Co. Llc2016-02-04Not applicableUs
Betacaine Gelgel5 %topicalProllenium Medical Technologies Inc2002-12-17Not applicableCanada
Bikini Reliefgel2 %topicalAlexandria International Inc.2000-02-152006-06-26Canada
Bikini Zonecream2 %topicalCCA Industries, Inc.1997-10-30Not applicableCanada
Bikini Zone Medicatedgel2 g/100gtopicalCCA Industries, Inc.2010-06-04Not applicableUs
Bikini Zone Medicated Cremecream2 g/100gtopicalCCA Industries, Inc.2010-06-03Not applicableUs
Bikini Zone Medicated Cremecream2 g/100gtopicalCCA Industries, Inc.2010-06-04Not applicableUs
Bikini Zone Topical Analgesic Gelgel2 %topicalCCA Industries, Inc.Not applicableNot applicableCanada
Bio-scriptives Lidumcream2.8 g/56gtopicalBio Chemics, Inc2010-07-23Not applicableUs
Bio-scriptives Lidum Hemorroidal (anorectal)cream2.8 g/56gtopicalBio Scriptives, Inc.2012-03-04Not applicableUs
Burnspray20 mg/LtopicalAcme United Corp2014-10-06Not applicableUs
Burnspray20 g/LtopicalFirst Aid Only, Inc2014-08-13Not applicableUs
Burn Creamcream2.25 %topicalWatkins Incorporated2000-02-022013-08-02Canada
Burn Jelgel2 g/100mLtopicalWater Jel Technologies2010-04-17Not applicableUs
Burn Jel 20 mg/gjelly20 mgtopicalWater Jel Technologies,Llc1992-12-311997-07-03Canada
Burn Jel Plusgel2.5 g/100mLtopicalWater Jel Technologies2010-04-10Not applicableUs
Burn Mistspray2 g/100mLtopicalWater Jel Technologies2010-05-17Not applicableUs
Burn Relief Gel With Lidocainegel0.72 %topicalPrime Enterprises Inc2005-06-15Not applicableCanada
Burn Relief Leaderspray.05 g/100gtopicalCardinal Health2011-12-01Not applicableUs
Burn Relief Pain Reliever Well At Walgreensspray.5 g/100gtopicalWalgreens2013-03-15Not applicableUs
Burn Reliefpreferred Plus Ph Preferred Plus Pharmacygel.5 g/100mLtopicalKinray Inc.2013-03-15Not applicableUs
Burn With Aloespray200 g/LtopicalProvision Medical2014-08-29Not applicableUs
Bz Step Pain Relief Creamcream.04 mg/mgtopicalBusiness Avenue, Llc2016-03-25Not applicableUs
Caribbean Breeze Burn Reliefgel1.0 %topicalCaribbean Breeze International Inc.2007-07-25Not applicableCanada
Comfortcainegel40 mg/gtopicalQS Key West Aloe, LLC2004-11-12Not applicableUs
Curacainecream4 g/100mLtopicalTransdermal Corp2012-09-12Not applicableUs
Curacainecream4 g/100mLtopicalTransdermal Corp2015-03-03Not applicableUs
Curacaine Transdermal Corporationcream40 mg/mLtopicalTransdermal Corp2012-09-12Not applicableUs
Cutiecainecream50 mg/gtopicalTransdermal Corp2011-11-15Not applicableUs
Cutiecainecream4 %topicalInnovatech IncNot applicableNot applicableCanada
Cutiecainecream40 mg/gtopicalInnovatech Inc2010-05-31Not applicableUs
Cutiecaine-5%cream5 %topicalInnovatech IncNot applicableNot applicableCanada
Cvs Burn Relief W/lido 8ozgel.5 g/100gtopicalCVS Pharmacy2015-07-08Not applicableUs
Derma Gel Reliefgel0.5 %topicalJamp Pharma CorporationNot applicableNot applicableCanada
Derma Numbspray50 mg/gtopicalAtlas Tat Inc.2014-08-06Not applicableUs
Dermanumb Tattoo Anestheticgel40 mg/gtopicalA.t.s. Laboratories, Llc2015-07-01Not applicableUs
Dermanumb Tattoo Anesthetic Gelgel40 mg/gtopicalA.t.s. Laboratories, Llc2015-07-01Not applicableUs
Desert Harvest Releveumcream40 mg/mLtopicalDesert Harvest Inc.2014-07-30Not applicableUs
Dr. Numbcream5 %topicalShinpharma Inc2013-10-08Not applicableCanada
Dr. Numbcream5 g/100gtopicalEi Inc.2012-11-15Not applicableUs
Dr. Richs Numbinggel4 g/100gtopicalGen Z Online Llc2014-08-27Not applicableUs
Dynamo Delayspray10 mg/.08mLtopicalMomentum Management2015-05-13Not applicableUs
Ebsl-5kitWater Jel Technologies2014-06-11Not applicableUs
Ebss-5kitWater Jel Technologies2014-06-11Not applicableUs
Eclipse Topical Anestheticcream40 mg/mLtopicalSambria Pharmaceuticals, Inc.2015-04-11Not applicableUs
Eclipse Topical Anestheticcream40 mg/gtopicalSambria Pharmaceuticals2015-08-20Not applicableUs
Endurance Rx Male Desensitizerspray10 mg/100mLtopicalM.D. Science Lab, Llc2015-06-09Not applicableUs
Endure Male Genital Desensitizingspray10 mg/100mLtopicalEndure Holdings, Llc2015-02-18Not applicableUs
Exchange Select Burn Relief Pain Relievinggel.5 g/100gtopicalArmy and Air Force Exchange Service2012-11-15Not applicableUs
Exsel Aloegel.5 g/100gtopicalArmy and Air Force Exchange Service2013-08-06Not applicableUs
Extra Strength Aftertatcream20 mg/1000mgtopicalRidge Properties2015-09-07Not applicableUs
Extra Strength Pretatcream40 mg/1000mgtopicalRidge Properties2015-06-08Not applicableUs
Extra Strength Pretatliquid40 mg/1000mgtopicalRidge Properties2015-06-08Not applicableUs
Ez Pain Relievingcream4 mg/mLtopicalE2 Brokers Inc.2013-11-062015-12-29Us
Fruit Of The Earth Aloe Vera Cool Bluegel10 mg/gtopicalFruit Of The Earth, Inc.2014-09-10Not applicableUs
Fruit Of The Earth Cool Blue Aloe Mist Continuousspray10 mg/mLtopicalFruit Of The Earth, Inc.2014-09-12Not applicableUs
Fsk-5kitWater Jel Technologies2014-06-11Not applicableUs
Gardeners Skin Remedy Topical Analgesic Gelgel2 %topicalCrabtree & Evelyn Ltd.1998-03-272003-07-18Canada
General Numbgel5 g/100gtopicalEsba Laboratories Inc.2015-05-01Not applicableUs
Gigi Anesthetic Numbingaerosol40 mg/gtopical220 LABORATORIES INC1997-10-27Not applicableUs
Good Neighbor Pharmacy Aloe Veragel500 g/100000mgtopicalAMERISOURCEBERGEN DRUG CORPORATION1988-11-28Not applicableUs
Good Neighbor Pharmacy Burn Relief Aloe Extraspray.5 g/100gcutaneousAmerisource Bergen Drug Corporation2011-10-28Not applicableUs
H-releve Hemorrhoidalcream4 g/100gtopicalPure Source Inc.2013-08-152016-01-07Us
H2ocean Nothing Tattoo Glide and Soothing Balmointment4 g/100gtopicalAidance Skincare & Topical Solutions, LLC2015-06-29Not applicableUs
Harmony Numbing Creamcream5.0 %topicalAgrisan Specialty Chemical & PharmaceuticalNot applicableNot applicableCanada
Hawaiian Tropicgel.8 g/100gtopicalEnergizer Personal Care LLC2010-09-28Not applicableUs
Hawaiian Tropic After Sun Après Soleil Sunburn Relief Soulagement Des Coups De Soleilgel0.8 %topicalEnergizer Canada Inc2010-02-152015-08-14Canada
Hem-easy Relief Herbal Hemorrhoidalcream45 mg/mLtopicalBatool Pharma International, Inc2014-08-20Not applicableUs
Hush Anestheticspray40 mg/gtopicalHUSH Anesthetic2012-12-01Not applicableUs
Hush Anestheticgel40 mg/gtopicalHUSH Anesthetic2012-12-01Not applicableUs
I.C.E. Lidocaine Gel - Gel Lidocainegel0.5 %topicalEnergizer Canada Inc2004-10-282012-07-12Canada
Instant Burn Relief Aloe Extra Cvsspray.5 g/100gtopicalCVS2014-11-11Not applicableUs
Instant Cool Skin Instant Relief. Sudden Resultslotion.5 g/100mLtopicalTherapon Skin Health, LP2015-06-15Not applicableUs
Iwk-5kitWater Jel Technologies2014-06-12Not applicableUs
Jampocaine 2% Viscous Solutionsolution2 %topicalJamp Pharma Corporation2014-09-29Not applicableCanada
Jampocaine 5%ointment5 %topicalJamp Pharma Corporation2014-05-14Not applicableCanada
Kroger Burn Relief Aloegel.5 g/100gtopicalThe Kroger Co2012-11-19Not applicableUs
Lidocaineaerosol, spray.64 g/127gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Lidocaineaerosol, spray.64 g/127gtopicalChain Drug Consortium, LLC2005-12-07Not applicableUs
Lidocainecream50 mg/gtopicalCounty Line Pharamceuticals2015-09-14Not applicableUs
Lidocainecream40 mg/gtopicalCounty Line Pharmaceuticals, LLC2014-09-02Not applicableUs
Lidocainecream4 g/100gtopicalPd Rx Pharmaceuticals, Inc.2011-10-01Not applicableUs
Lidocaineaerosol, spray.64 g/127gtopicalTopco Associates LLC2012-01-03Not applicableUs
Lidocaine 4%cream4 g/100gtopicalAlexso Inc2016-03-01Not applicableUs
Lidocaine 4% Creamcream4 g/100gtopicalCutis Health, LLC2014-12-01Not applicableUs
Lidocaine 5%cream5 g/100gtopicalTri Marc Labs2011-10-01Not applicableUs
Lidocaine Hydrochlorideliquid200 mL/LtopicalAfassco Inc.2012-02-16Not applicableUs
Lidocaine Hydrochloridespray20 g/LtopicalCintas First Aid & Safety2013-04-18Not applicableUs
Lidocaine Hydrochlorideliquid20 mg/mLtopicalSafetec of America, Inc.2011-08-02Not applicableUs
Lidocaine Hydrochloridegel20 mg/gtopicalSafetec of America, Inc.2012-09-19Not applicableUs
Lidocaine Hydrochloridegel20 mg/gtopicalAcme United Corporation2013-02-14Not applicableUs
Lidocaine Hydrochloridespray20 g/LtopicalUnifirst First Aid Corporation2015-06-10Not applicableUs
Lidocaine Hydrochloride Solutionspray, bag-on-valve1 %topicalPrime Enterprises Inc2013-08-20Not applicableCanada
Lidocaine Ointment USP, 5%ointment5 %topicalNovocol Pharmaceutical Of Canada IncNot applicableNot applicableCanada
Lidocaine Plus Maximum Strength Pain Relieving Creamcream39.2 mg/mLtopicalPrime Enterprises Inc.2007-03-02Not applicableUs
Lidocare Mistspray20 mg/mLtopicalSesvalia USA LLC2014-04-04Not applicableUs
Lidocollspray4.6 g/115gtopicalInnocoll Pharmaceuticals2011-01-01Not applicableUs
Lidocream 10cream10 g/100gtopicalGolden Touch LLC2015-05-05Not applicableUs
Lidocream 4cream4 g/100gtopicalGolden Touch LLC2010-12-01Not applicableUs
Lidocream 5cream5 g/100gtopicalGolden Touch LLC2010-12-01Not applicableUs
Lidocream 5cream5 g/100gtopicalGolden Touch LLC2010-12-01Not applicableUs
Lidocream 5cream5 g/100gtopicalGolden Touch LLC2010-12-01Not applicableUs
Lidodan Cream 4%cream4 %topicalOdan Laboratories LtdNot applicableNot applicableCanada
Lidodan Cream 5%cream5 %topicalOdan Laboratories LtdNot applicableNot applicableCanada
Lidodan Jelly 2%jelly20 mgtopicalOdan Laboratories Ltd2002-03-27Not applicableCanada
Lidodan Viscous 2%liquid2 %buccalOdan Laboratories Ltd1994-12-31Not applicableCanada
Lidoflexpatch28.1 mg/.24mgtopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
Lidoflexpatch25.3 mg/.24mgtopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
Lidoflexpatch25.8 mg/.24mgtopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
Lidoflexpatch22.7 mg/.24mgtopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
Lidoflexpatch29 mg/.24mgtopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
Lidoflex Elbow, Single Pouchpatch21.5 mg/.24mgtopicalNaimco, Inc. Dba Richmar, Inc.2014-09-01Not applicableUs
Lidomax 5cream5 %topicalVivier Canada Incorporated2007-10-032014-07-16Canada
Lidoplus Pain Reliefcream40 mg/mLtopicalCentura Pharmaceuticals, Inc2015-12-25Not applicableUs
Lidosport Pain Reliefcream40 mg/mLtopicalCentura Pharmaceuticals, Inc2015-12-25Not applicableUs
Lidostatcream40 mg/gtopicalClinical Therapeutic Solutions2013-06-19Not applicableUs
Lifestyles Epic Male Genital Desensitizerspray10 mg/.1mLtopicalAnsell Healthcare Inc2011-11-022016-01-20Us
Lmx4cream40 mg/gtopicalFerndale Laboratories, Inc.2011-01-03Not applicableUs
Lmx5cream50 mg/gtopicalFerndale Laboratories, Inc.2003-10-01Not applicableUs
Lyracaine Gelgel5 %topicalProllenium Medical Technologies Inc2014-09-04Not applicableCanada
Male Genital Desensitizer Stud 100spray, metered9.6 mg/100mLtopicalPound International Corp2013-03-13Not applicableUs
Maxilene 4cream4 %topicalRgr Pharma Ltd.2003-05-15Not applicableCanada
Maxilene 5cream5 %topicalRgr Pharma Ltd.2003-05-15Not applicableCanada
Med Numbspray40 mg/gtopicalAtlas Tat Inc.2015-10-01Not applicableUs
Medi-first Burngel20 mg/gtopicalUnifirst First Aid Corporation2014-07-30Not applicableUs
Medifirst Burnspray20 g/LtopicalUnifirst First Aid Corporation2013-04-12Not applicableUs
Meijer Burn Relief Aloe Vera Pain Relieving Gelgel.5 g/100gtopicalMeijer Distribution Inc2013-07-12Not applicableUs
Microcaine Topical Analgesiccream50 mg/gtopicalUnit Dose, Ltd.2016-01-19Not applicableUs
Naturally Hl Extra Strength Bedsore Numbingliquid40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Bedsore Numbingcream40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Burn Numbingliquid40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Burn Numbingcream40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Hemorrhoid Numbingliquid40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Hemorrhoid Numbingcream40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Insect Bite Numbingliquid40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Insect Bite Numbingcream40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Numbingliquid40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Naturally Hl Extra Strength Numbingcream40 mg/1000mgtopicalRidge Properties2016-04-06Not applicableUs
Neuromed 7 Topical Pain Reliefcream4 g/100gtopicalSambria Pharmaceuticals, Llc2013-08-15Not applicableUs
Neuromed Arcream50 mg/mLtopicalSambria Pharmaceuticals, Inc.2015-08-04Not applicableUs
No-AD Aloe Vera Gel 98% Puregel0.5 %topicalSolar Cosmetic Labs, Inc.2001-01-062005-07-26Canada
No-AD Sunburn Relief Gelgel0.5 %topicalSolar Cosmetic Labs, Inc.2003-02-012005-07-26Canada
North Burn Reliefspray24.64 mg/mLtopicalNorth Safety Products2013-03-15Not applicableUs
Numb 520cream5 mg/gtopicalClinical Resolution Laboratory, Inc.2015-12-18Not applicableUs
Numb Mastercream5 mg/gtopicalClinical Resolution Laboratory, Inc.2014-04-24Not applicableUs
Numb Nutscream4 g/100gtopicalMiss Smarty Pants Enterprises, Inc.2010-06-10Not applicableUs
Numb Zonegel5 g/100gtopicalEsba Laboratories Inc.2015-07-01Not applicableUs
Number 5cream5 %topicalAlera Skin Care Products Inc.Not applicableNot applicableCanada
Numbs Upgel40 mg/mLtopicalSambria Pharmaceuticals, Inc.2015-04-12Not applicableUs
Ocean Potion Instant Burn Relief Icegel.5 g/100gtopicalSun & Skin Care Research, LLC2012-01-01Not applicableUs
Pain Prescriptives 4lotion40 mg/4mLtopicalSambria Pharmaceuticals, Llc2016-02-012016-02-04Us
Pain Prescriptives 4cream40 mg/mLtopicalSambria Pharmaceuticals2016-01-05Not applicableUs
Pain Prescriptives 5cream50 mg/mLtopicalSambria Pharmaceuticals2015-12-22Not applicableUs
Pain Relief Cvscream4 g/100gtopicalCVS2016-03-15Not applicableUs
Pain Relief Well At Walgreenscream4 g/100gtopicalWalgreens2015-07-30Not applicableUs
Panama Jack Burn Relief Gel With Lidocainegel7.13 mg/mLtopicalPrime Enterprises Inc.2015-10-19Not applicableUs
Paraid Burngel2 mg/gtopicalMcure Health Solutions Inc.2015-12-25Not applicableUs
Planticin Advanced Topical Pain Reliefcream40 mg/gtopicalPedicis Research, Llc2016-04-21Not applicableUs
Plum Smooth Plumb Numb Geleegel4 g/100gtopicalUniversal Companies, Inc.2012-03-29Not applicableUs
PMS-lidocaine Viscous 2%liquid2 %dentalPharmascience Inc1990-12-31Not applicableCanada
Pre-wax Pain Reliefspray2.6 %topicalAvon Canada Ulc2006-05-112007-07-26Canada
Pre-wax Sprayspray4 %topicalProduct Excellence Inc.2008-01-312010-03-04Canada
Predatorcream40 mg/gtopicalSambria Pharmaceuticals, Llc2012-12-01Not applicableUs
Predatorcream400 mg/mgtopicalSambria Pharmaceuticals, Llc2013-02-11Not applicableUs
Predatorcream400 mg/mgtopicalSambria Pharmaceuticals, Llc2013-02-11Not applicableUs
Premjactspray, metered dose9.6 %topicalPound International Ltd.Not applicableNot applicableCanada
Premjact Male Desensitizer Pound Internationalspray, metered9.6 g/100mLtopicalPound International2013-05-09Not applicableUs
Promescentspray10 g/100gtopicalAbsorption2013-01-11Not applicableUs
Publix Burn Reliefgel.5 g/100gtopicalPublix Super Markets Inc2012-11-15Not applicableUs
Publix Burn Relief Aloe Veragel.5 g/100gtopicalPublix Super Markets Inc2013-07-12Not applicableUs
Recovery Numbcream.05 g/gtopicalSambria Pharmaceucals, Inc.2013-03-22Not applicableUs
Recticarecream50 mg/gtopicalFerndale Laboratories, Inc.2012-03-09Not applicableUs
Regenecare Hagel20 mg/mLtopicalMPM Medical, Inc.2009-06-01Not applicableUs
Regenecare Hagel20 mg/gtopicalMPM Medical, Inc.2007-01-05Not applicableUs
Regenecare Hydrogelgel2 %topicalMethapharm IncNot applicableNot applicableCanada
Res-Q Analgesic Topical Pain Reliefliquid40 mg/mLtopicalConair Corporation2014-02-26Not applicableUs
Res-Q Analgesic Topical Pain Relief Sprayspray4 %topicalDtr Dermal Therapy Research Inc.2014-08-18Not applicableCanada
Res-Q Topical Analgesic Soothinggel4 g/100gtopicalConair Corporation2014-02-26Not applicableUs
Res-Q Topical Analgesic Soothing Gelgel4 %topicalDtr Dermal Therapy Research Inc.2014-08-18Not applicableCanada
Rite Aid Burn Reliefgel.5 g/100gtopicalRite Aid Corporation2012-12-03Not applicableUs
Safetec Burn Gelgel2 %topicalSafetec Of America Inc2001-11-012013-08-07Canada
Safetec Burn Sprayspray2 %topicalSafetec Of America Inc2002-07-292013-08-07Canada
Safetec Sting Reliefsolution2 %topicalSafetec Of America Inc2001-11-012014-09-09Canada
Select Brand Burn Reliefgel.5 g/100gtopicalSelect Brand Distributors2012-11-19Not applicableUs
Shave Zonegel2.0 %topicalCCA Industries, Inc.Not applicableNot applicableCanada
Simplicity Desensitizinggel40 mg/mLtopicalSimplicity Laser, LLC2014-07-15Not applicableUs
Simply Numb Endurecream5 g/100gtopicalGolden Touch LLC2014-07-08Not applicableUs
Simply Numb Endurecream5 g/100gtopicalGolden Touch LLC2014-07-08Not applicableUs
Simply Numb Endurecream5 g/100gtopicalGolden Touch LLC2014-07-08Not applicableUs
Simply Numb Endurecream5 g/100gtopicalGolden Touch LLC2014-07-08Not applicableUs
Skin Envy Soothing Creamcream2 %topicalFarleyco Marketing, Inc.2014-02-04Not applicableCanada
Smartshield After Sungel1 %topicalSmartshield Sunscreens2004-11-08Not applicableCanada
Solarcainespray5 mg/gtopicalMSD Consumer Care, Inc.2012-04-06Not applicableUs
Solarcaine Cool Aloegel5 g/10gtopicalBayer Health Care Llc2012-03-13Not applicableUs
Solarcaine First Aid Lidocaine Sprayaerosol0.5 %topicalBayer Inc Consumer Care1990-12-31Not applicableCanada
Solarcaine Medicated First Aid Lotionlotion0.5 %topicalBayer Inc Consumer Care1997-05-12Not applicableCanada
Solarcaine Medicated Lidocaine Gelgel0.5 %topicalBayer Inc Consumer Care2006-02-01Not applicableCanada
Sole Serumspray4 g/100mLtopicalTHE COMFORT LAB LLC2014-02-24Not applicableUs
Solmate Burn Relief Gelgel.057 mg/mLtopicalPrime Enterprises, Inc.2015-04-01Not applicableUs
Sonacaine Topical Anesthetic With Mentholgel4 g/100gtopicalFilltech Usa, Llc2012-05-02Not applicableUs
Soothing Gel With Lidocainegel0.50 %topicalEnergizer Canada Inc2008-02-142015-08-14Canada
Soulus Rp Rash and Paincream.5 g/100gtopicalPure Source Inc2011-03-23Not applicableUs
Stallionspray, metered dose9.6 %topicalLockerroom Marketing Ltd2008-06-26Not applicableCanada
Stud 100spray, metered dose9.6 %topicalPound International Ltd.1997-07-15Not applicableCanada
Sunburn Reliefaerosol0.5 %topicalTender CorporationNot applicableNot applicableCanada
Suntone After Sun Burn Relief Gel With Lidocainegel7.13 mg/mLtopicalPrime Enterprises Inc.2011-11-07Not applicableUs
Swabplus Piercing Care Swabsswab1 %topicalSwabplus Canada Inc.2003-06-152008-09-22Canada
Topicaine 5gel5 g/100gtopicalEsba Laboratories Inc.2003-04-20Not applicableUs
Topicaine 5gel5 %topicalEsba Laboratories Inc2009-03-01Not applicableCanada
Unburnspray2.5 g/100mLtopicalWater Jel Technologies2014-02-01Not applicableUs
Unburngel2.5 g/100mLtopicalWater Jel Technologies2013-03-17Not applicableUs
Unburn-gel 2.5%gel2.5 %topicalWater Jel Technologies,Llc1997-03-031997-07-03Canada
Walgreens Aloe Vera Burn Relief Pain Relievinggel.5 g/100gtopicalWALGREEN CO.2012-12-04Not applicableUs
Water-jel Burn Jel-2%gel2 %topicalZEE MEDICAL1994-12-31Not applicableCanada
Watkins Burn Creamcream1 %topicalWatkins Incorporated1998-07-012000-02-02Canada
Western Family Aloe Vera Moisturizinggel.5 g/100gtopicalWestern Family Foods, Inc.2014-07-02Not applicableUs
X3 On The Go First Aid Bite Relief Spraysolution2 %topicalNatural Essentials IncNot applicableNot applicableCanada
X3 On The Go First Aid Burn Relief Spraysolution0.5 %topicalNatural Essentials IncNot applicableNot applicableCanada
X3 On-the-GO First Aid Burn Relief Sprayspray0.5 %topicalNatural Essentials Inc2012-04-24Not applicableCanada
Xolidocream4 g/mLtopicalEnovachem Manufacturing2013-04-05Not applicableUs
Xolidocream2 g/mLtopicalEnovachem Manufacturing2013-04-05Not applicableUs
Xylocaine Mpfliquid1 %intraspinal; percutaneousAstrazeneca L.P.1997-05-212001-10-12Canada
Yowch Extra Strength for Insect Bites and Stingscream40 mg/1000mgtopicalRidge Properties Llc2015-11-30Not applicableUs
Yowch Extra Strength for Minor Burnscream40 mg/1000mgtopicalRidge Properties2015-11-30Not applicableUs
Yowch for Insect Bites and Stings By Pain Balmcream20 mg/1000mgtopicalRidge Properties2015-09-07Not applicableUs
Yowch for Minor Burns By Pain Balmcream20 mg/1000mgtopicalRidge Properties2015-09-07Not applicableUs
Zcaine Fast Acting Anestheticgel4 g/100gtopicalPHI, Inc2012-04-04Not applicableUs
Zensacream5 g/100gtopicalAlera Skin Care Products Inc.2016-01-04Not applicableUs
Zensacream5 %topicalAlera Skin Care Products Inc.2016-05-20Not applicableCanada
Zilactin-Lliquid2.5 %topicalZila Pharmaceuticals Inc.1998-02-172006-07-04Canada
Zilactin-L Early Relief Cold Sore Liquidsolution4.0 %topicalBlairex Laboratories, Inc.2005-06-022008-07-23Canada
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apicaine-Xointment.05 g/gtopicalMedicap Laboratories Inc.2015-12-122016-02-19Us
Cidaleazecream30 mg/gtopicalAlvix Laboratories, LLC2015-08-11Not applicableUs
Dermacinrx Lidotralcream38.8 mg/gtopicalPure Tek Corporation2015-12-03Not applicableUs
Lidocaineointment5 g/100gtopicalTwo Hip Consulting, Llc2016-03-25Not applicableUs
Lidocaine HClcream30 mg/gtopicalPure Tek Corporation2011-06-13Not applicableUs
Lidocaine HClinjection, solution20 mg/mLinfiltrationCantrell Drug Company2015-02-25Not applicableUs
Lidocaine Hydrochloridecream30 mg/gtopicalSeton Pharmaceuticals2011-06-20Not applicableUs
Lidocaine Hydrochloridegel30 mg/gtopicalProficient Rx LP2013-03-012016-01-05Us
Lidocaine Hydrochloridegel30 mg/gtopicalUnit Dose Services2013-03-01Not applicableUs
Lidocaine Hydrochloridegel30 mg/gtopicalGensco Laboratories, LLC2013-03-01Not applicableUs
Lidocaine Hydrochloridegel30 mg/gtopicalLake Erie Medical DBA Quality Care Products LLC2013-03-01Not applicableUs
Lidocaine Hydrochloridelotion5.31 mL/177mLtopicalStratus Pharamceuticals2012-03-01Not applicableUs
Lidocaine Hydrochloridegel30 mg/gtopicalAidarex Pharmaceuticals LLC2013-03-01Not applicableUs
Lidocaine Hydrochloridelotion3 g/100mLtopicalAlvix Laboratories,Llc2015-03-02Not applicableUs
Lidocaine Hydrochloride Viscousgel2 g/100mLoralTrue Fit Rx Llc2015-07-06Not applicableUs
Lidocingel7.2 g/240gtopicalPharmaceutics Corporation2015-02-202015-12-29Us
Lidopincream32.5 mg/gtopicalAdler Stern Pharmaceuticals, Llc2014-11-11Not applicableUs
Lidovexcream37.5 mg/gtopicalSterling Knight Pharmaceuticals, Llc2014-12-14Not applicableUs
Lidovincream39.5 mg/gtopicalSterling Knight Pharmaceuticals,Llc2015-04-30Not applicableUs
Lidozolcream37.5 mg/gtopicalSterling Knight Pharmaceuticals,Llc2015-04-30Not applicableUs
Mericainegel.04 g/gtopicalMerit Pharmaceutical2015-07-01Not applicableUs
Premium Lidocaine 5% Extraointment.005 mg/gtopicalZhejiang Bangli Medical Products Co., Ltd2015-03-01Not applicableUs
Premium Lidocaine 5% Extraointment.005 mg/gtopicalAlivio Medical Products, Llc2015-03-01Not applicableUs
International Brands
NameCompany
After Burn Double Strength GelNot Available
After Burn Double Strength SprayNot Available
After Burn GelNot Available
After Burn SprayNot Available
AlphacaineNot Available
Anestacon JellyNot Available
DermaFlexNot Available
DilocaineNot Available
EsracaineNot Available
L-CaineNot Available
Lidoject-1Not Available
Lidoject-2Not Available
LidoPain SPNot Available
Norwood Sunburn SprayNot Available
XylocardNot Available
Brand mixtures
NameLabellerIngredients
0.4% Lidocaine Hydrochloride and 5% Dextrose Injection USPHospira Healthcare Corporation
10 Person AnsiGenuine First Aid LLC
1st Relief Topical1st Class Pharmaceuticals, Inc.
2% Lidocaine and Epinephrine 1:100,000 Injection USPAlveda Pharmaceuticals Inc
25 Person AnsiGenuine First Aid LLC
3-step First Aid KitSwabplus Inc.
5% Xylocaine Mpf With Glucose 7.5% InjectionSmiths Medical Canada Ltd.
50 Person AnsiGenuine First Aid LLC
Acme First Aid Contains 404 PiecesAcme United Corp.
Acme Small Cuts and BurnsAcme United Corp.
AdazinSterling Knight Pharmaceuticals, Llc
Aerowound Blood Clotting First AidAero Healthcare, Llc.
Aflexeryl-LCEasy Distributors, Llc
AlocaneQuest Products, Inc.
Alocane PlusQuest Products, Inc.
Ana-lexAvion Pharmaceuticals, Llc
AnodynerxGen Pak Solutions Llc
Antibiotic Cream for KidsTaro Pharmaceuticals Inc
Antibiotic Cream Plus Pain ReliefPharmetics (2011) Inc
Antibiotic Cream Plus Pain Relief for KidsCanadian Custom Packaging Company
Antibiotic Plus Pain Relief CreamTaro Pharmaceuticals Inc
AntisepticUnifirst First Aid Corporation
Antiseptic Formula Filled SwabSwabplus Inc.
Apr15Aleviar Pharma Corp
Arc Emergency Preparedness First Aid Contains 202 PiecesAmerican Red Cross
Arc First Aid Contains 1000 PiecesAmerican Red Cross
Arc First Aid Contains 101 PiecesAmerican Red Cross
Arc First Aid Contains 101 Pieces HardcaseAmerican Red Cross
Arc First Aid Contains 404 PiecesAmerican Red Cross
Arrow Central Venous Catheterization KitArrow International Inc.
Arrow Multi-lumen Central Venous Catheter KitArrow International Inc.
Arrow Pneumothorax KitArrow International Inc.
Arrow Two-lumen Central Venous Cathetar KitArrow International Inc.
Arrow Two-lumen Jugular Catheterization KitArrow International Inc.
Aubio Life Sciences LipAubio Life Sciences Llc
Auto 157Genuine First Aid LLC
AvadermPure Source, Inc.
Avalin External Analgesic PatchRx Change Co.
Avon Foot Works Therapeutic Cracked Heel Relief CreamAvon Canada Ulc
Baciguent Plus Pain Reliever OntUpjohn Consumer Products Company
Bactine First Aid SprayWellspring Pharmaceutical Canada Corp
Bactine First Aid Spray LiqMiles Canada Inc. Consumer Health Care Division
Bactine Original First AidBayer Health Care Llc, Consumer Care
Bactine Pain RelievingBayer Health Care Llc, Consumer Care
Bakers Best Arthritis Pain ReliefBaker's Best
Banana Boat Sooth-A-caine Spray GelPlaytex Ltd.
Banana Boat Sooth-A-caine W.moist.aloe V.gelThe Banana Boat Company
Band-aid Brand Hurt-free Antiseptic WashJohnson & Johnson Consumer Products Company, Division of Johnson & Johnson Consumer Companies, Inc.
Bekoool Itch ReliefKobayashi America Manufacturing, Llc
Bene PatchZhejiang Bangli Medical Products Co., Ltd
BenepatchMeds Direct Rx, Inc.
Benzalkonium Chloride and Lidocaine HydrochlorideCVS Pharmacy
Biochemistry Pain Relief Foot ActivePure Source, Inc.
Biotic-plusProvision Medical
Blood Clotting First AidUnifirst First Aid Corporation
Braline PatchDoc Rx
Budpak First AidBudpak Inc.
Burn Relief CreamHumn Pharmaceuticals Inc
Burn Relief GelEnergizer Canada Inc
Burn With LidocaineUnifirst First Aid Corporation
Burncare KitAvacare, Division Of Jeunique International Inc.
CacitrixOrimed Pharma Corporation
Central Vein Catheterization KitArrow International Inc.
Central Venous Catetherization KitArrow International Inc.
Central Venous Catheter Expanded KitEdwards Lifesciences (Canada) Inc.
CicloferonMarcas Usa Llc
Coachs First Aid Contains 102 PiecesCramer Sports
Comfort Ez Extra Strength Pain Relief PatchSimple Diagnostics, Inc.
Comfort Ez Extra Strengthtransdermal PatchSimple Diagnostics, Inc.
Comfort Ez Pain Relief PatchSimple Diagnostics, Inc.
Complete Antibiotic OintmentTaro Pharmaceuticals Inc
Continuous Epidural Anesthesia TrayBaxter Corporation
Cvs Antiseptic WashCVS Pharmacy
Cvs Bacitracin With Pain ReliefCVS Pharmacy
Daymark Fak-35 First AidCmc Group
De LA Cruz MercurochromeDLC Laboratories, Inc.
Dentsply 2% Lidocaine With Epinephrine 1:100,000Dentsply Canada Limited
Dentsply 2% Lidocaine With Epinephrine 1:50,000Dentsply Canada Limited
Depo-medrol With LidocainePfizer Canada Inc
Derma-caineUnifirst First Aid Corporation
Dermatologic ReliefJamp Pharma Corporation
Dipentocaine Topical Cream Compounding KitAlvix Laboratories, LLC
Disposable Convenience Kit (single Shot Epidural)True Fit Rx Llc
Doans Pain RelievingDucere Pharma
Dolor-parche With Lidocaine-RXTwo Hip Consulting, Llc
Doloracin/l Rx With LidocaineTwo Hip Consulting, Llc
Dr. Scholl's Cracked Heel Relief CreamSchering Plough Canada Inc
Dynarex Burn CreamDynarex Corporation
Elite Pain ReliefMeds Direct Rx, Inc.
EmlaActavis Pharma, Inc.
Emla CrmAstrazeneca Canada Inc
Emla PatchAstrazeneca Canada Inc
EndoxcinPharmaceutica North America, Inc.
Epidural Anesthesia TrayBaxter Corporation
Expanded Multi-med KitEdwards Lifesciences (Canada) Inc.
Family Medic First Aid Treatment - LiqTender Corporation
Family Medic First-aid Treatment LiquidTender Corporation
Family Medic First-aid Treatment LotionTender Corporation
First AidProvision Medical
First Aid and BurnAcme United Corporation
First Aid Antiseptic SwabsAvon Canada Ulc
First Aid Antiseptic Well At WalgreensWalgreens
First Aid BurnWater Jel Technologies
First Aid Contains 101 PiecesGenuine First Aid LLC
First Aid Contains 101 Pieces HardcaseGenuine First Aid LLC
First Aid Contains 303 PiecesGenuine First Aid LLC
First Aid Macimum Sterngth Bacitraycin PlusFirst Aid Research Corp
First Aid Pocket Pack - 40 PiecesReady America, Inc.
First Aid Research Bacitraycin Plus Maximum VerticalFirst Aid Research Corp.
First Aid SprayNorwood Packaging Ltd
First Aid Triple Antibiotic With Pain RelieverCintas First Aid & Safety
First Aid Value Pack - 77 PiecesReady America, Inc.
Foot Works Cracked HeelAvon Products, Inc.
Foot Works Healthy Cracked Heel CreamAvon Canada Ulc
Footworks Healthy Cracked Heel CreamAvon Canada Ulc
Footworks Maximum Strength Cracked HeelNew Avon Llc
Freds Antiseptic WashPharma Pac, Llc
Genetic Amniocentesis Tray KitAllegiance Healthcare Corporation
Genuine First Aid BurnGfa Production (Xiamen) Co., Ltd.
Genuine First Aid Burn Antiseptic Pain Relief With AloeGenuine First Aid
Genuine First Aid Industrial First AidGenuine First Aid, LLC
Gfa First AidGenuine First Aid, LLC
Gfa First Aid 16 Unit Metal CaseGenuine First Aid, LLC
Gfa First Aid 24 Unit Metal CaseGenuine First Aid, LLC
Gfa First Aid 36 Unit Metal CaseGenuine First Aid, LLC
Good Neighbor Pharmacy Emergency Preparedness and First Aid Contains 167 PiecesAmerisource Bergen
Good Neighbor Pharmacy First Aid Contains 202 PiecesAmerisource Bergen
Green Guard Derma-caineUnifirst First Aid Corporation
Green Guard Super Stat Blood Clotting First AidUnifirst First Aid Corporation
Healerz for NosesWellco Brands LLC
HemawayMelaleuca, Inc.
Humco MercuroclearHumco Holding Group, Inc
Hush AnestheticHUSH Anesthetic
Hyaluronic Acid 60mg and Lidocaine 2% PFUs Compounding, Inc
Hydrocath Central Venous Catheter KitOhmeda (Singapore) Pte Ltd.
Icy Hot With Lidocaine Pain RelievingChattem, Inc.
InstillagelPendopharm Division Of De Pharmascience Inc
Itch Relief CreamHumn Pharmaceuticals Inc
IV Infusion CpiPure Tek Corporation
Jamshidi Bone Marrow Biopsy TrayAllegiance Healthcare Corporation
Jamshidi Menghini Soft Tissue Biopsy TrayAllegiance Healthcare Corporation
K-mart Smartsense First Aid Contains 101 PiecesK Mart
Kds Lab Liquid StypticKds Lab
Keepan ASato Pharmaceutical Co., Ltd.
Kroger Aloe Vera Pain RelievingThe Kroger Co
LenzagelPharmaceutica North America, Inc.
LenzapatchPharmaceutica North America, Inc.
LexilidoAlexso, Inc.
LidallMed Vantage Pharmaceutical, Llc
Lidenza PatchPatchwerx Labs, Inc.
Lido-RX 4.1Cloverleaf Pharma Llc
LidocaineHenry Schein Inc.
Lidocaine 0.2% In 5% Dextrose InjHospira Healthcare Corporation
Lidocaine 2.5% and Prilocaine 2.5% CreamWelgo, Llc
Lidocaine 2% and Epinephrine 1:100 000Kodak Canada Inc.
Lidocaine 2% and Epinephrine 1:100,000Carestream Health Canada Company
Lidocaine 2% and Epinephrine 1:100,000 InjectionAlveda Pharmaceuticals Inc
Lidocaine 2% and Epinephrine 1:50 000Kodak Canada Inc.
Lidocaine 2% and Epinephrine 1:50,000Carestream Health Canada Company
Lidocaine and Epinephrine Inj.usp 2% 1:100000Mylan Pharmaceuticals Ulc
Lidocaine and PrilocaineImpax Generics
Lidocaine HClPearson Dental
Lidocaine HCl - Hydrocortisone AcetatePure Tek Corporation
Lidocaine HCl - Hydrocortisone Acetate With AloePure Tek Corporation
Lidocaine HCl 0.2% and Dextrose 5% InjBaxter Corporation
Lidocaine HCl 0.4% and 5% Dextrose InjBaxter Corporation
Lidocaine HCl 0.8% and 5% Dextrose InjBaxter Corporation
Lidocaine HCl and Dextrose 5% Inj USPB. Braun Medical Inc
Lidocaine HCl and Hydrocortisone AcetateAcella Pharmaceuticals, LLC
Lidocaine Hydrochloride 0.5% and Epinephrine 1:200000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride 1.5% and Epinephrine 1:200000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride 1.5% and Epinephrine 1:200000 Injection USP Test DoseHospira Healthcare Corporation
Lidocaine Hydrochloride 1% and Epinephrine 1:100 000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride 2% and Epinephrine 1:100 000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride 2% and Epinephrine 1:200000 Injection USPHospira Healthcare Corporation
Lidocaine Hydrochloride and 5% Dextrose Injection USPB. Braun Medical Inc
Lidocaine Hydrochloride and DextroseB. Braun Medical Inc.
Lidocaine Hydrochloride and EpinephrineHospira, Inc.
Lidocaine Hydrochloride and Epinephrine BitartrateIq Dental
Lidocaine Hydrochloride and Hydrocortisone AcetateSeton Pharmaceuticals
Lidocaine-prilocaine-cream BaseHumco Holding Group, Inc.
LidomyxinSandoz Canada Incorporated
LidonexePatchwerx Labs, Inc.
LidopatchJar Laboratories
Lidopatch Pain Relief3 T Federal Solutions Llc
Lidoplus Pain Relief PatchCentura Pharmaceuticals Inc
LidoproTerrain Pharmaceuticals
Lidopro PatchTerrain Pharmaceuticals
Lidosporin CreamGlaxo Wellcome Inc.
Lidosporin Ear DropsGlaxo Wellcome Inc.
Lidosport Pain Relief PatchCentura Pharmaceuticals Inc
LidotholTerrain Pharmaceuticals
Lignospan ForteNovocol Pharmaceutical of Canada, Inc.
Lignospan Speciale InjSeptodont
Lignospan StandardNovocol Pharmaceutical of Canada, Inc.
LimencinAlexso Inc
LiprotekUnit Dose, Ltd.
Lipsorex PlusSanofi Consumer Health Inc Sanofi Sante Grand Public Inc
Lorenza Pain Relief PatchHome Aide Diagnostics, Inc.
Makesense First AidCherry Hill Sales Co
Medi-derm / L With LidocaineTwo Hip Consulting, Llc
Medi-derm / L With Lidocaine RxTwo Hip Consulting, Llc
Medi-first First Aid Burn CreamUnifirst First Aid Corporation
Medi-first Plus Burn CreamUnifirst First Aid Corporation
Medi-patch With LidocaineTwo Hip Consulting, Llc
Medi-patch With Lidocaine RxTwo Hip Consulting, Llc
Medi-quik First Aid AntisepticQuantum Pharmaceuticals Inc.
Medi-quik First Aid SprayThe Mentholatum Company Of Canada Ltd
Medi-quik First-aid Spray - Aer TopThe Mentholatum Company Of Canada Ltd
Medi-sulting Topical Pain ReliefProficient Rx LP
Meijer Aloe GelMeijer Distribution Inc
Menthocin Patch With Lidocaine - StrongBonita Pharmaceuticals LLC
Mentholix1st Class Pharmaceuticals
Minims Lidocaine and FluoresceinChauvin Pharmaceuticals Limited
Mueller First Aid AntisepticMueller Sports Medicine, Inc.
Multi-lumen Central Venous Cathet KitArrow International Inc.
Neo-bex InjectableBrostel Inc.
Neutrogena Anti-itch MoisturizerJohnson & Johnson Inc
North Antiseptic First AidNorth Safety Products, Llc.
NothingH2 Ocean, Llc
Numpot Topical AnestheticUnit Dose, Ltd.
Numquick AnalgesicUnit Dose, Ltd.
Numquick Topical AnalgesicUnit Dose, Ltd.
NumstickUnit Dose, Ltd.
Octocaine 100Septodont
Octocaine 100 Needleject InjNovocol Pharmaceutical Of Canada Inc
Octocaine 50Septodont
Octocaine HCl 2% Epinephrine 1:100000Novocol Pharmaceutical Of Canada Inc
Octocaine HCl 2% Epinephrine 1:50000Novocol Pharmaceutical Of Canada Inc
Odynia-R RegularUrsh Pharmaceutical Inc.
OraqixDentsply Pharmaceutical
Otizol HC LiqLab Nadeau LtÉe, Division Of Technilab Inc.
Ozonol Antibiotic Plus - OintmentBayer Inc Consumer Care
Ozonol Antibiotic Plus OntSterling Winthrop Inc.
Ozonol Antibiotics PlusBayer Inc Consumer Care
Pain ReliefGenuine Virgin Aloe Corporation
Pain Relief PatchBinger Consulting Corporation
Pain Relieving Cleansing SprayTender Corporation
Paracentesis Tray W Boasberg Catheter SetBaxter Corporation
Percutaneous Sheath Introducer TrayEdwards Lifesciences (Canada) Inc.
Peritoneal Lavage Kit InjArrow International Inc.
Permavan External PatchHome Aide Diagnostics, Inc.
Pharmacist Choice Pain Relief PatchSimple Diagnostics, Inc.
Pharmacist Choice Tsx Transdermal PatchSimple Diagnostics, Inc.
Pharmassist Soothenel GelNu Skin International, Inc.
Physician Ez Use Joint Tunnel and Trigger KitAsclemed Usa, Inc.
Pleura-seal Thoracentesis KitArrow International Inc.
PliaglisGalderma Laboratories, L.P.
Point Relief LidospotFabrication Enterprises
Polyderm Antibiotic OintmentPharmetics (2011) Inc
Polysporin Antibiotic Burn CreamWarner Lambert Canada Inc.
Polysporin Burn Formula CreamGlaxo Wellcome Inc.
Polysporin Cold Sore OintmentJohnson & Johnson Inc
Polysporin CompleteJohnson & Johnson Inc
Polysporin for KidsJohnson & Johnson Inc
Polysporin for StitchesJohnson & Johnson Inc
Polysporin Plus Pain ReliefJohnson & Johnson Inc
Polysporin Plus Pain Relief Ear DropsJohnson & Johnson Inc
Premium Scar PatchAlivio Medical Products, Llc
Procicept L Lidocaine 4%Nocicept Technologies, Inc.
ProcomycinPhysicians Science & Nature Inc.
ProlidaPronova Corp
Prostat Blood Clotting First AidPro Stat First Aid
ProvenzaSterling Knight Pharmaceuticals,Llc
Publix Burn ReliefPublix Super Markets Inc
PuroxcinPharmaceutics Corporation
Racestyptine CordSeptodont
Ready America First Aid Outdoor- 107 PiecesGenuine First Aid, LLC
Readysharp-ATerrain Pharmaceuticals
Readysharp-KTerrain Pharmaceuticals
Readysharp-p40Terrain Pharmaceuticals
Readysharp-p80Terrain Pharmaceuticals
RecticareFerndale Laboratories, Inc.
Recticare AdvancedFerndale Laboratories, Inc.
Recticare CompleteFerndale Laboratories, Inc.
Relador Pak PlusAccelis Pharma
Relador Pak With Occlusive DressingAccelis Pharma
Releevia Lm PatchPatchwerx Labs, Inc.
Relyyks PatchAlexso, Inc
Remaxazon External PatchHome Aide Diagnostics, Inc.
Renovo Lido5Tmig, Inc.
Renuu PatchPatchwerx Labs
RicoraMeds Direct Rx, Inc.
ScadexePatchwerx Labs, Inc.
Scar PatchBinger Consulting Corporation
Scar Zone Burn Extra Strength Burn Relief Topical Analgesic and AntisepticCCA Industries, Inc.
Scar Zone Burn GelCCA Industries, Inc.
Scar Zone Burn Topical Analgesic and AntisepticCCA Industries, Inc.
Silvera Pain Relief PatchHome Aide Diagnostics, Inc.
Single-shot Epidural Anesthesia TrayBaxter Corporation
SiterolBinger Consulting Corporation
Small Cuts and BurnsGenuine First Aid LLC
SolmaraSpring Hill Therapeutics Llc
Soothee PatchZhejiang Bangli Medical Products Co., Ltd
Spinal Anaesthesia TrayBaxter Corporation
Spinal Anesthesia TrayBaxter Corporation
Sting ReliefAcme United Corporation
Sun Burn Relief CreamHumn Pharmaceuticals Inc
SyneraGalen Us Incorporated
SynvexiaSterling Knight Pharmaceuticals,Llc
Synvexia TcSterling Knight Pharmaceuticals, Llc
Tecnu First AidTec Laboratories, Inc.
TerocinLake Erie Medical & Surgical Supply DBA Quality Care Products LLC
Terrasil Cold Sore Treatment MaxAidance Skincare & Topical Solutions, LLC
Terrasil Itch, Rash and Pain ReliefAidance Skincare & Topical Solutions, LLC
Terrasil Itch, Rash and Pain Relief MaxAidance Skincare & Topical Solutions, LLC
Top Safety First Aid Burn CreamTop Safety Products Company Inc
Tpr20Trans Research Labs Inc
Tribioticlc Lc LcHART Health
Triple AntibioticUnifirst First Aid Corporation
Velma Pain Relief PatchHome Aide Diagnostics, Inc.
VeltrixHome Aide Diagnostics, Inc.
Venia Patch Premium Pain PatchZhejiang Bangli Medical Products Co., Ltd
VexaPharmaceutics Corporation
Walgreens Aloe Vera Pain RelievingWALGREEN CO.
Walgreens First Aid AntisepticWalgreens
Walgreens Pain RelievingWALGREEN CO.
XpacaineSynergist Laboratories Llc
XylocaineGeneral Injectables & Vaccines, Inc
Xylocaine - Mpf 5% With Glucose 7.5%Astrazeneca L.P.
Xylocaine 0.5% W Epinephrine 1:100000Astrazeneca Canada Inc
Xylocaine 0.5% W Epinephrine 1:200000Astrazeneca Canada Inc
Xylocaine 1.5% W Epinephrine 1:200000Astrazeneca Canada Inc
Xylocaine 1.5% W Epinephrine 1:200000 Test DoseAstrazeneca Canada Inc
Xylocaine 1% W Epinephrine 1:100000Astrazeneca Canada Inc
Xylocaine 1% W Epinephrine 1:200000Astrazeneca Canada Inc
Xylocaine 2% W Epinephrine 1:100000Astrazeneca Canada Inc
Xylocaine 2% W Epinephrine 1:200000Astrazeneca Canada Inc
Xylocaine Dental Lidocaine HCl 2% and Epinephrine 1:100,000Dentsply Canada Limited
Xylocaine Dental Lidocaine Hydrochloride 2% and Epinephrine 1:50,000Dentsply Canada Limited
Xylocaine MpfCardinal Health
Xylocaine Mpf 1.5% With EpinephrineAstrazeneca L.P.
Xylocaine Oral SprayAstra Pharma Inc.
Xylonor GelSeptodont
Xylonor SpraySeptodont
Your Label Here Blood Clotting First AidDixon Investments, Inc.
Your Logo Here Antiseptic First AidDixon Investments, Inc.
Zims Max FreezeNATURAL ESSENTIALS, INC.
Salts
Name/CASStructureProperties
Lidocaine hydrochloride
ThumbNot applicableDBSALT000900
Lidocaine hydrochloride anhydrous
ThumbNot applicableDBSALT001508
Categories
UNII98PI200987
CAS number137-58-6
WeightAverage: 234.3373
Monoisotopic: 234.173213336
Chemical FormulaC14H22N2O
InChI KeyInChIKey=NNJVILVZKWQKPM-UHFFFAOYSA-N
InChI
InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
IUPAC Name
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
SMILES
CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • N-arylamide
  • Benzenoid
  • Monocyclic benzene moiety
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors
Pharmacology
IndicationFor production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
PharmacodynamicsLidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Lidocaine in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, lidocaine may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.
Mechanism of actionLidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain but by aborting their birth in the first place.
Related Articles
AbsorptionInformation derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.
Volume of distribution
  • 0.7 to 2.7 L/kg [healthy volunteers]
Protein binding60-80%
Metabolism

Primarily hepatic.

SubstrateEnzymesProduct
Lidocaine
3-hydroxylidocaineDetails
Lidocaine
monoethylglycinexylidideDetails
Lidocaine
Not Available
2,6-Dimethylaniline (2,6-Xylidine)Details
3-hydroxylidocaine
Not Available
3-HydroxymonoethylglycinexylidideDetails
monoethylglycinexylidide
Not Available
3-HydroxymonoethylglycinexylidideDetails
monoethylglycinexylidide
Not Available
2,6-Dimethylaniline (2,6-Xylidine)Details
monoethylglycinexylidide
Not Available
Glycinexylidide (GX)Details
Glycinexylidide (GX)
Not Available
2,6-Dimethylaniline (2,6-Xylidine)Details
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
2-Amino-3-methylbenzoateDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
4-Hydroxy-2,6-dimethylanilineDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
2-Amino-3-methylbenzoateDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
2-Amino-3-methylbenzoateDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
4-Hydroxy-2,6-dimethylanilineDetails
2,6-Dimethylaniline (2,6-Xylidine)
Not Available
4-Hydroxy-2,6-dimethylanilineDetails
Route of eliminationLidocaine and its metabolites are excreted by the kidneys.
Half life109 minutes
Clearance
  • 0.64 +/- 0.18 L/min
ToxicityThe oral LD 50 of lidocaine HCl in non-fasted female rats is 459 (346-773) mg/kg (as the salt) and 214 (159-324) mg/kg (as the salt) in fasted female rats. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Lidocaine (Local Anaesthetic) Action PathwayDrug actionSMP00398
Lidocaine (Antiarrhythmic) Action PathwayDrug actionSMP00328
Lidocaine (Local Anaesthetic) Metabolism PathwayDrug metabolismSMP00620
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Astrazeneca lp
  • Noven pharmaceuticals inc
  • Carlisle laboratories inc
  • E fougera div altana inc
  • Graham chemical co
  • Taro pharmaceuticals usa inc
  • Teikoku pharma usa inc
  • Abbott laboratories pharmaceutical products div
  • Abbott laboratories hosp products div
  • Abraxis pharmaceutical products
  • Akorn inc
  • Baxter healthcare corp anesthesia and critical care
  • Bel mar laboratories inc
  • Dell laboratories inc
  • Elkins sinn div ah robins co inc
  • Gd searle llc
  • Hospira inc
  • International medication systems ltd
  • International medication system
  • Luitpold pharmaceuticals inc
  • Miles laboratories inc
  • Watson laboratories inc
  • Wyeth ayerst laboratories
  • Baxter healthcare corp
  • B braun medical inc
  • App pharmaceuticals llc
  • Meridian medical technologies inc
  • Dentsply pharmaceutical
  • Polymedica industries inc
  • Teva pharmaceuticals usa
  • Hi tech pharmacal co inc
  • Wockhardt eu operations (swiss) ag
  • Actavis mid atlantic llc
  • Vintage pharmaceuticals llc
  • Roxane laboratories inc
  • Kendall co
  • Paco research corp
  • Anesiva inc
Packagers
Dosage forms
FormRouteStrength
Solutionintravenous20 mg
Liquidsubarachnoidal
Kit
Solutiontopical1 %
Liquid; spraytopical0.5 %
Geltopical0.5 %
Geltopical2.5 g/100g
Kittopical
Gelophthalmic35 mg/mL
Ointmenttopical4 g/100mL
Geltopical.5 g/100mL
Geltopical.5 g/100g
Liquidblock/infiltration; subcutaneous1 %
Creamtopical5 g/100g
Creamtopical5 g/100mL
Liquidepidural1 %
Ointmenttopical.05 g/g
Kit; liquidintravenous
Liquidintravenous
Liquidintra-articular1 %
Patchtopical246 mg/1
Ointmenttopical246 mg/1
Lotiontopical4 g/100g
Creamtopical2 g/100g
Implantintradermal.3 %
Geltopical4.1 mg/mL
Liquidtopical
Geltopical0.7 %
Liquidtopical2 %
Geltopical5 %
Creamtopical2 %
Geltopical2 g/100g
Creamtopical2.8 g/56g
Aerosol, spraytopical
Spraytopical20 mg/L
Creamtopical2.25 %
Geltopical2 g/100mL
Geltopical2.5 g/100mL
Spraytopical2 g/100mL
Geltopical0.72 %
Spraytopical.05 g/100g
Spraytopical.5 g/100g
Spraytopical200 g/L
Spraytopical2.4 %
Creamtopical.04 mg/mg
Geltopical1.0 %
Geltopical20 mg
Liquid; ointmentintravenous; topical
Kit; liquid; ointmentblock/infiltration; parenteral (unspecified); subcutaneous; topical
Liquidblock/infiltration; subcutaneous; epidural
Creamtopical4 g/100mL
Creamtopical40 mg/mL
Solutionintra-articular; intrabursal
Spraytopical50 mg/g
Creamtopical38.8 mg/g
Kittopical
Spraytopical10 mg/.08mL
Kit
Spraytopical10 mg/100mL
Kitblock/infiltration; epidural
Solution; kit; ointmentblock/infiltration; intravenous; topical
Creamtopical20 mg/1000mg
Creamtopical40 mg/1000mg
Liquidtopical40 mg/1000mg
Creamtopical4 mg/mL
Liquid; spraytopical
Swabtopical
Spraytopical
Geltopical10 mg/g
Spraytopical10 mg/mL
Geltopical2 %
Kitintra-amniotic
Aerosoltopical40 mg/g
Geltopical500 g/100000mg
Spraycutaneous.5 g/100g
Ointmenttopical4 g/100g
Creamtopical5.0 %
Geltopical.8 g/100g
Geltopical0.8 %
Creamtopical45 mg/mL
Soaptopical
Spraytopical40 mg/g
Injection, solutionintra-articular
Liquid; ointmentepidural; topical
Lotiontopical.5 g/100mL
Lotiontopical
Liquidintratracheal40 mg
Aerosol, spraytopical.64 g/127g
Ointmenttopical35.44 g/g
Ointmenttopical5 g/100g
Ointmenttopical50 mg/g
Patchcutaneous140 mg/1
Patchcutaneous700 mg/1
Liquidblock/infiltration
Creamtopical
Creamrectal; topical
Solutionintravenous
Liquidblock/infiltration; epidural10 mg
Liquidintravenous20 mg
Creamtopical30 mg/g
Geltopical20 mg/g
Geltopical30 mg/g
Geltopical40 mg/g
Injectionepidural; infiltration; intracaudal10 mg/mL
Injectioninfiltration; intravenous10 mg/mL
Injectioninfiltration; intravenous20 mg/mL
Injectioninfiltration; intravenous5 mg/mL
Injectionintravenous20 mg/mL
Injectionparenteral20 mg/mL
Injection, solutionepidural; infiltration10 mg/mL
Injection, solutionepidural; infiltration15 mg/mL
Injection, solutionepidural; infiltration20 mg/mL
Injection, solutionepidural; infiltration; intracaudal; perineural10 mg/mL
Injection, solutionepidural; infiltration; intracaudal; perineural20 mg/mL
Injection, solutioninfiltration10 mg/mL
Injection, solutioninfiltration20 mg/mL
Injection, solutioninfiltration5 mg/mL
Injection, solutioninfiltration; intravenous5 mg/mL
Injection, solutionintravenous10 mg/mL
Injection, solutionintravenous20 mg/mL
Injection, solutionretrobulbar; topical40 mg/mL
Jellytopical20 mg/mL
Liquidtopical20 mg/mL
Liquidtopical200 mL/L
Lotiontopical3 g/100mL
Lotiontopical5.31 mL/177mL
Solutionoral20 mg/mL
Solutionoropharyngeal20 mg/mL
Solutionoropharyngeal20 mg/100mL
Solutiontopical20 mg/mL
Solutiontopical40 mg/mL
Spraytopical20 g/L
Solutionblock/infiltration; epidural
Injection, solutionintravenous
Injection, solutionintravenous4 mg/mL
Injection, solutionintravenous400 mg/100mL
Injection, solutionintravenous8 mg/mL
Injection, solutionintravenous800 mg/100mL
Injectioninfiltration
Injection, solutiondental; infiltration
Injection, solutionepidural
Injection, solutionepidural; infiltration
Injection, solutioninfiltration
Creamrectal
Gelrectal
Liquidblock/infiltration20 mg
Solutionblock/infiltration10 mg
Liquidblock/infiltration2 %
Solutionblock/infiltration20 mg
Spray, bag-on-valvetopical1 %
Geloral2 g/100mL
Ointment5 g
Creamtopical39.2 mg/mL
Solutionoral; topical20 mg/mL
Spraytopical20 mg/mL
Geltopical7.2 g/240g
Spraytopical4.6 g/115g
Creamtopical10 g/100g
Solutiontopical4 %
Liquidtopical10 mg
Jellytopical2 %
Ointmenttopical5 %
Liquidbuccal2 %
Patchcutaneous700 mg/12h
Liquidcutaneous700 mg/1000mg
Patchtopical22.7 mg/.24mg
Patchtopical25.3 mg/.24mg
Patchtopical25.8 mg/.24mg
Patchtopical28.1 mg/.24mg
Patchtopical29 mg/.24mg
Patchtopical21.5 mg/.24mg
Liquidotic
Patchtopical
Patchtransdermal
Creamtopical32.5 mg/g
Creamtopical37.5 mg/g
Creamtopical39.5 mg/g
Spraytopical10 mg/.1mL
Creamtopical40 mg/g
Creamtopical50 mg/g
Liquidsubcutaneous1 %
Spray, meteredtopical9.6 mg/100mL
Creamtopical4 %
Creamtopical5 %
Aerosoltopical
Geltopical.04 g/g
Dropsophthalmic; topical
Liquid; ointmentsubcutaneous; topical
Liquidblock/infiltration; intraspinal; subcutaneous1 %
Solutionintramuscular; intravenous
Creamtopical50 mg/mL
Spray, meteredtopical
Spraytopical24.64 mg/mL
Creamtopical5 mg/g
Geltopical40 mg/mL
Solutiontopical
Sticktopical
Liquiddental; subcutaneous
Injection, solutionsubcutaneous
Liquidsubcutaneous
Gelperiodontal
Suspensionotic
Lotiontopical40 mg/4mL
Creamtopical4 g/100g
Geltopical7.13 mg/mL
Liquidblock/infiltration; subcutaneous; topical
Geltopical2 mg/g
Liquidintravenous1 %
Solution; kit; ointmentblock/infiltration; subcutaneous; topical
Kitinfiltration; intra-articular; intramuscular; respiratory (inhalation); topical
Liquidintravenous; epidural
Liquiddental2 %
Dropsotic
Spraytopical2.6 %
Spraytopical4 %
Solutiontopical40 mg
Creamtopical400 mg/mg
Ointmenttopical.005 mg/g
Spray, meteredtopical9.6 g/100mL
Spraytopical10 g/100g
Corddental
Kitepidural; infiltration
Kitepidural; infiltration; intra-articular; intramuscular; topical
Kitepidural; infiltration; intra-articular; intralesional; intramuscular; soft tissue
Creamtopical.05 g/g
Clothtopical
Geltopical20 mg/mL
Liquidtopical40 mg/mL
Geltopical4 g/100g
Geltopical4 %
Spraytopical2 %
Solutiontopical2 %
Geltopical2.0 %
Geltopical1 %
Spraytopical5 mg/g
Geltopical5 g/10g
Aerosoltopical0.5 %
Lotiontopical0.5 %
Spraytopical4 g/100mL
Geltopical.057 mg/mL
Geltopical0.50 %
Creamtopical.5 g/100g
Kitblock/infiltration; topical
Liquidparenteral (unspecified); topical
Liquidblock/infiltration; subcutaneous
Kitblock/infiltration1 %
Spray, metered dosetopical9.6 %
Swabtopical1 %
Patchcutaneous
Ointmenttopical
Liquidintrathoracic; subcutaneous1 %
Geltopical5 g/100g
Spraytopical2.5 g/100mL
Geltopical2.5 %
Geltopical
Creamtopical1 %
Solutiontopical0.5 %
Spraytopical0.5 %
Creamtopical2 g/mL
Creamtopical4 g/mL
Injectioninfiltration10 mg/mL
Injection, solutionepidural; infiltration; intracaudal; perineural
Injection, solutioninfiltration; perineural
Injection, solutioninfiltration; perineural10 mg/mL
Injection, solutioninfiltration; perineural20 mg/mL
Injection, solutioninfiltration; perineural5 mg/mL
Jellytopical.5 mg/18mL
Liquidintraspinal
Liquidblock/infiltration5 mg
Solutionblock/infiltration5 mg
Solutionepidural15 mg
Liquidblock/infiltration10 mg
Solutionblock/infiltration
Solutionepidural20 mg
Jellyurethral20 mg
Liquidepidural
Liquidsubarachnoidal50 mg
Solutionblock/infiltration; epidural17.3 mg
Solutionoral100 mg
Jellytopical20 mg
Injection, solutionepidural; infiltration; intracaudal; perineural15 mg/mL
Liquidintraspinal; percutaneous1 %
Liquidpercutaneous1 %
Liquidblock/infiltration1 %
Aerosoloral; topical
Spraytopical40 mg
Liquidtopical50 mg
Liquidoral; topical20 mg
Solutionretrobulbar; topical40 mg/mL
Liquidintracaudal; epidural20 mg
Liquidintravenous100 mg
Liquidintravenous200 mg
Liquidtopical2.5 %
Solutiontopical4.0 %
Powderintradermal.5 mg/1
Prices
Unit descriptionCostUnit
Rocephin 10 gm vial478.32USD each
Lidocaine HCl 3% Lotion 177ml Bottle230.3USD bottle
Rocephin 2 gm vial97.5USD each
Rocephin 1 gm vial62.02USD each
EMLA 2.5-2.5% Cream 30 gm Tube58.4USD tube
Lidocaine-Prilocaine 2.5-2.5% Cream 30 gm Tube47.79USD tube
Lidocaine HCl 2% Gel 10ml Syringe17.99USD syringe
Lidocaine HCl 2% Gel 30ml Tube17.99USD tube
Lidocaine HCl 4% Solution 50ml Bottle16.99USD bottle
Lidocaine Viscous 2% Solution 100ml Bottle13.99USD bottle
Lidocaine hcl 1% syringe9.76USD ml
Lidocaine HCl 4% Solution 4ml Bottle9.42USD bottle
Lidoderm 1 Box = 30 Patches8.03USD patch
Akten 3.5% drops7.5USD ml
Lidocaine 5% in d7.5w ampul3.06USD ml
Lidocaine 3% cream2.91USD g
Lidamantle 3% cream2.03USD g
Zilactin-l cold sore liquid0.99USD ml
Xylocaine 2% jelly0.68USD ml
Lidocaine hcl 10% vial0.55USD ml
Xylocaine 5% ointment0.42USD g
Xylocaine Jelly 2 % Jelly0.41USD g
Xylocaine 2% Solution0.34USD ml
Xylocaine 5 % Ointment0.29USD g
Lidocaine HCl 1% Solution0.24USD ml
Lidocaine hcl powder0.24USD g
Lidocaine base powder0.22USD g
Lidocaine hcl 4% solution0.18USD ml
Xylocaine 0.5% vial0.18USD ml
Lidodan 5 % Ointment0.16USD g
Xylocaine Viscous 2 % Liquid0.1USD ml
Lidocaine hcl 0.5% vial0.08USD ml
Solarcaine aerosol0.06USD g
Lidodan Viscous 2 % Liquid0.06USD ml
Lidocaine 2% viscous solution0.03USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5234957 No1994-02-272011-02-27Us
US5658583 No1995-07-282015-07-28Us
US5827529 No1995-10-272015-10-27Us
US5899880 No1996-05-042016-05-04Us
US5919479 No1995-07-282015-07-28Us
US6004286 No1997-03-172017-03-17Us
US6031007 No1997-04-012017-04-01Us
US6306431 No1995-07-282015-07-28Us
US6465006 No1995-07-282015-07-28Us
US6465709 No2000-07-072020-07-07Us
US6528086 No1999-09-282019-09-28Us
US6546281 No1995-07-282015-07-28Us
US6629968 No2000-06-302020-06-30Us
US6635045 No2001-06-292021-06-29Us
US6780426 No1995-07-282015-07-28Us
US6881200 No1996-06-112016-06-11Us
US8540665 No2009-10-222029-10-22Us
US8759401 No2006-07-242026-07-24Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point68.5 °CPhysProp
boiling point159-160 °C at 2.00E+00 mm HgPhysProp
water solubility4100 mg/L (at 30 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP2.44AVDEEF,A (1997)
logS-1.76ADME Research, USCD
Caco2 permeability-4.21ADME Research, USCD
pKa8.01SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.593 mg/mLALOGPS
logP1.81ALOGPS
logP2.84ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)13.78ChemAxon
pKa (Strongest Basic)7.75ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area32.34 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity73.93 m3·mol-1ChemAxon
Polarizability27.77 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.18 KB)
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-000i-9000000000-38a47958df650b972703View in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
References
Synthesis Reference

DrugSyn.org

US2441498A
General References
  1. Khaliq W, Alam S, Puri N: Topical lidocaine for the treatment of postherpetic neuralgia. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD004846. [PubMed:17443559 ]
  2. Thomson PD, Melmon KL, Richardson JA, Cohn K, Steinbrunn W, Cudihee R, Rowland M: Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. Ann Intern Med. 1973 Apr;78(4):499-508. [PubMed:4694036 ]
  3. Geha PY, Baliki MN, Chialvo DR, Harden RN, Paice JA, Apkarian AV: Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy. Pain. 2007 Mar;128(1-2):88-100. Epub 2006 Oct 25. [PubMed:17067740 ]
  4. Hines R, Keaney D, Moskowitz MH, Prakken S: Use of lidocaine patch 5% for chronic low back pain: a report of four cases. Pain Med. 2002 Dec;3(4):361-5. [PubMed:15099246 ]
External Links
ATC CodesC01BB01N01BB02D04AB01R02AD02S02DA01C05AD01S01HA07N01BB52
AHFS Codes
  • 24:04.04
  • 24:04.04.08
  • 52:16.00
  • 72:00.00
  • 84:08.00
PDB EntriesNot Available
FDA labelDownload (548 KB)
MSDSDownload (74.6 KB)
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with 7-Nitroindazole.
AbirateroneThe serum concentration of Lidocaine can be increased when it is combined with Abiraterone.
AcebutololThe serum concentration of Lidocaine can be increased when it is combined with Acebutolol.
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Lidocaine.
AcepromazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Aceprometazine.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Lidocaine.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Lidocaine.
adipiplonThe risk or severity of adverse effects can be increased when Lidocaine is combined with adipiplon.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Lidocaine.
AgomelatineThe serum concentration of Agomelatine can be increased when it is combined with Lidocaine.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Lidocaine.
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Lidocaine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Lidocaine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alfentanil.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Lidocaine.
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Lidocaine.
AlosetronThe metabolism of Alosetron can be decreased when combined with Lidocaine.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Alprazolam.
AlprenololThe serum concentration of Lidocaine can be increased when it is combined with Alprenolol.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Lidocaine.
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Lidocaine.
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Lidocaine.
AmiodaroneThe serum concentration of Lidocaine can be increased when it is combined with Amiodarone.
AmiodaroneLidocaine may increase the arrhythmogenic activities of Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Amisulpride.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Lidocaine.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Lidocaine.
AmobarbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Amobarbital.
AmoxapineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Amperozide.
AnagrelideThe metabolism of Anagrelide can be decreased when combined with Lidocaine.
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Lidocaine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Lidocaine.
AprepitantThe serum concentration of Lidocaine can be increased when it is combined with Aprepitant.
AprepitantThe metabolism of Aprepitant can be decreased when combined with Lidocaine.
AripiprazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with Aripiprazole.
ArotinololThe serum concentration of Lidocaine can be increased when it is combined with Arotinolol.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Lidocaine.
ArtemetherThe metabolism of Lidocaine can be decreased when combined with Artemether.
ArticaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Articaine.
ASA404The metabolism of ASA404 can be decreased when combined with Lidocaine.
AsenapineThe metabolism of Asenapine can be decreased when combined with Lidocaine.
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Lidocaine.
AtazanavirThe metabolism of Lidocaine can be decreased when combined with Atazanavir.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Lidocaine.
AtenololThe serum concentration of Lidocaine can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Lidocaine can be decreased when combined with Atomoxetine.
AV650The metabolism of AV650 can be decreased when combined with Lidocaine.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Lidocaine.
AzaperoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Azaperone.
AzelastineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Lidocaine.
AzithromycinThe metabolism of Lidocaine can be decreased when combined with Azithromycin.
BaclofenThe risk or severity of adverse effects can be increased when Lidocaine is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Barbital.
BefunololThe serum concentration of Lidocaine can be increased when it is combined with Befunolol.
BendamustineThe metabolism of Bendamustine can be decreased when combined with Lidocaine.
BenzocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Benzocaine.
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Lidocaine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Lidocaine.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Lidocaine.
BetaxololThe serum concentration of Lidocaine can be increased when it is combined with Betaxolol.
BetaxololThe metabolism of Betaxolol can be decreased when combined with Lidocaine.
BevantololThe serum concentration of Lidocaine can be increased when it is combined with Bevantolol.
BexaroteneThe serum concentration of Lidocaine can be decreased when it is combined with Bexarotene.
BisoprololThe serum concentration of Lidocaine can be increased when it is combined with Bisoprolol.
BoceprevirThe metabolism of Lidocaine can be decreased when combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Lidocaine.
BopindololThe serum concentration of Lidocaine can be increased when it is combined with Bopindolol.
BortezomibThe metabolism of Lidocaine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Lidocaine can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Lidocaine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Lidocaine.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
BrimonidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brimonidine.
BromazepamThe metabolism of Bromazepam can be decreased when combined with Lidocaine.
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Lidocaine.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Lidocaine.
BrompheniramineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Brotizolam.
BufuralolThe serum concentration of Lidocaine can be increased when it is combined with Bufuralol.
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Lidocaine.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Lidocaine.
BupranololThe serum concentration of Lidocaine can be increased when it is combined with Bupranolol.
BuprenorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Buprenorphine.
BupropionThe metabolism of Bupropion can be decreased when combined with Lidocaine.
BuspironeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Buspirone.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Lidocaine.
ButacaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butethal.
ButorphanolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Butorphanol.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Lidocaine.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Lidocaine.
CaffeineThe metabolism of Lidocaine can be decreased when combined with Caffeine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Lidocaine.
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Lidocaine.
CapecitabineThe metabolism of Lidocaine can be decreased when combined with Capecitabine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Lidocaine.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Lidocaine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carfentanil.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Lidocaine.
CarisoprodolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carisoprodol.
CarmustineThe metabolism of Carmustine can be decreased when combined with Lidocaine.
CarteololThe serum concentration of Lidocaine can be increased when it is combined with Carteolol.
CarvedilolThe serum concentration of Lidocaine can be increased when it is combined with Carvedilol.
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Lidocaine.
CelecoxibThe metabolism of Lidocaine can be decreased when combined with Celecoxib.
CeliprololThe serum concentration of Lidocaine can be increased when it is combined with Celiprolol.
CeritinibThe serum concentration of Lidocaine can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Lidocaine.
CetirizineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlordiazepoxide.
ChlormezanoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chloroprocaine.
ChloroquineThe metabolism of Lidocaine can be decreased when combined with Chloroquine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlorphenamine.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Lidocaine.
ChlorpromazineThe metabolism of Lidocaine can be decreased when combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Chlorprothixene.
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Lidocaine.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Lidocaine.
CholecalciferolThe metabolism of Lidocaine can be decreased when combined with Cholecalciferol.
CilostazolThe metabolism of Cilostazol can be decreased when combined with Lidocaine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Lidocaine.
CimetidineThe metabolism of Lidocaine can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Lidocaine.
CinchocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cinchocaine.
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Lidocaine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Lidocaine.
CisaprideThe metabolism of Cisapride can be decreased when combined with Lidocaine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Lidocaine.
CitalopramThe risk or severity of adverse effects can be increased when Lidocaine is combined with Citalopram.
CitalopramThe metabolism of Lidocaine can be decreased when combined with Citalopram.
ClarithromycinThe metabolism of Lidocaine can be decreased when combined with Clarithromycin.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Lidocaine.
ClemastineThe metabolism of Lidocaine can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clemastine.
ClenbuterolThe metabolism of Clenbuterol can be decreased when combined with Lidocaine.
ClevidipineThe metabolism of Clevidipine can be decreased when combined with Lidocaine.
ClidiniumThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clidinium.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Lidocaine.
ClobazamThe metabolism of Lidocaine can be decreased when combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with clomethiazole.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Lidocaine.
ClomipramineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clomipramine.
ClomipramineThe metabolism of Lidocaine can be decreased when combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clonazepam.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Lidocaine.
ClonidineThe risk or severity of adverse effects can be increased when Clonidine is combined with Lidocaine.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Lidocaine.
ClopidogrelThe metabolism of Lidocaine can be decreased when combined with Clopidogrel.
ClorazepateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Clorazepate.
ClotrimazoleThe metabolism of Lidocaine can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Lidocaine.
ClozapineThe metabolism of Lidocaine can be decreased when combined with Clozapine.
CobicistatThe serum concentration of Lidocaine can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Lidocaine.
CocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cocaine.
CodeineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Codeine.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Lidocaine.
ConivaptanThe serum concentration of Lidocaine can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Lidocaine.
CrizotinibThe metabolism of Lidocaine can be decreased when combined with Crizotinib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Lidocaine.
CyclizineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cyclizine.
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Lidocaine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Lidocaine.
CyclosporineThe metabolism of Lidocaine can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Lidocaine.
CyproheptadineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Cyproheptadine.
Cyproterone acetateThe serum concentration of Lidocaine can be decreased when it is combined with Cyproterone acetate.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Lidocaine.
DabrafenibThe serum concentration of Lidocaine can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Lidocaine.
DacarbazineThe metabolism of Dacarbazine can be decreased when combined with Lidocaine.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Lidocaine.
DantroleneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dantrolene.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Lidocaine.
DapiprazoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dapiprazole.
DapoxetineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dapoxetine.
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Lidocaine.
DarifenacinThe metabolism of Lidocaine can be decreased when combined with Darifenacin.
DarunavirThe serum concentration of Lidocaine can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Lidocaine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Lidocaine.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Lidocaine.
DeferasiroxThe serum concentration of Lidocaine can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Lidocaine can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when Lidocaine is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Desflurane.
DesipramineThe metabolism of Desipramine can be decreased when combined with Lidocaine.
DesloratadineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Detomidine.
DexamethasoneThe serum concentration of Lidocaine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Lidocaine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dexbrompheniramine.
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Lidocaine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dexmedetomidine.
DextromoramideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dextropropoxyphene.
DezocineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dezocine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Lidocaine.
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Lidocaine.
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Lidocaine.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Lidocaine.
DifenoxinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Difenoxin.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Lidocaine.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Lidocaine.
DihydrocodeineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dihydrocodeine.
DihydroergotamineThe metabolism of Lidocaine can be decreased when combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dihydromorphine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lidocaine.
DiltiazemThe metabolism of Lidocaine can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Lidocaine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dimenhydrinate.
DinoprostoneThe metabolism of Dinoprostone can be decreased when combined with Lidocaine.
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Lidocaine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Diphenoxylate.
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Lidocaine.
DisopyramideDisopyramide may increase the arrhythmogenic activities of Lidocaine.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Lidocaine.
DofetilideLidocaine may increase the arrhythmogenic activities of Dofetilide.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lidocaine.
DoramectinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Doramectin.
DoxepinThe metabolism of Doxepin can be decreased when combined with Lidocaine.
DoxepinThe risk or severity of adverse effects can be increased when Doxepin is combined with Lidocaine.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Lidocaine.
DoxorubicinThe metabolism of Lidocaine can be decreased when combined with Doxorubicin.
DoxycyclineThe metabolism of Lidocaine can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
DoxylamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Lidocaine is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
DronedaroneLidocaine may increase the arrhythmogenic activities of Dronedarone.
DronedaroneThe metabolism of Lidocaine can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Droperidol.
DrotebanolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Drotebanol.
DuloxetineThe metabolism of Duloxetine can be decreased when combined with Lidocaine.
DyclonineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dyclonine.
EcgonineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Lidocaine is combined with ECGONINE METHYL ESTER.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Lidocaine.
EfavirenzThe serum concentration of Lidocaine can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Lidocaine is combined with Efavirenz.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Lidocaine.
EliglustatThe metabolism of Lidocaine can be decreased when combined with Eliglustat.
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Lidocaine.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Lidocaine.
EntacaponeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Entacapone.
EnzalutamideThe serum concentration of Lidocaine can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Lidocaine.
ErgotamineThe metabolism of Ergotamine can be decreased when combined with Lidocaine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Lidocaine.
ErythromycinThe metabolism of Lidocaine can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Lidocaine.
EscitalopramThe risk or severity of adverse effects can be increased when Lidocaine is combined with Escitalopram.
Eslicarbazepine acetateThe serum concentration of Lidocaine can be decreased when it is combined with Eslicarbazepine acetate.
EsmololThe serum concentration of Lidocaine can be increased when it is combined with Esmolol.
EstazolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Estazolam.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Lidocaine.
EstriolThe serum concentration of Estriol can be increased when it is combined with Lidocaine.
EstroneThe serum concentration of Estrone can be increased when it is combined with Lidocaine.
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Lidocaine.
EszopicloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Eszopiclone.
EthanolLidocaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Lidocaine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Lidocaine.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lidocaine.
EthosuximideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etomidate.
EtoperidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etoperidone.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Lidocaine.
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Lidocaine.
EtorphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etorphine.
EtravirineThe serum concentration of Lidocaine can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Lidocaine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Lidocaine.
EzogabineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Felbamate.
FelodipineThe metabolism of Lidocaine can be decreased when combined with Felodipine.
FencamfamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fentanyl.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lidocaine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Lidocaine.
FexofenadineThe risk or severity of adverse effects can be increased when Fexofenadine is combined with Lidocaine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Lidocaine.
FlibanserinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Flibanserin.
FloxuridineThe metabolism of Lidocaine can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Lidocaine can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fludiazepam.
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Lidocaine.
FlunarizineThe risk or severity of adverse effects can be increased when Flunarizine is combined with Lidocaine.
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Lidocaine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Lidocaine.
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Lidocaine.
FluoxetineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluoxetine.
FluoxetineThe metabolism of Lidocaine can be decreased when combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluspirilene.
FlutamideThe metabolism of Flutamide can be decreased when combined with Lidocaine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Lidocaine.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluticasone Propionate.
FluvastatinThe metabolism of Lidocaine can be decreased when combined with Fluvastatin.
FluvoxamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fluvoxamine.
FluvoxamineThe metabolism of Lidocaine can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Lidocaine can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Lidocaine can be increased when it is combined with Fosaprepitant.
FosphenytoinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Fospropofol.
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Lidocaine.
Fusidic AcidThe serum concentration of Lidocaine can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Gabapentin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Lidocaine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Lidocaine is combined with Gamma Hydroxybutyric Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Lidocaine.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Lidocaine.
GemfibrozilThe metabolism of Lidocaine can be decreased when combined with Gemfibrozil.
GenisteinThe metabolism of Genistein can be decreased when combined with Lidocaine.
GlutethimideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Glutethimide.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Lidocaine.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Lidocaine.
GuanabenzThe metabolism of Guanabenz can be decreased when combined with Lidocaine.
GuanfacineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Halazepam.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Lidocaine.
HaloperidolThe metabolism of Lidocaine can be decreased when combined with Haloperidol.
HalothaneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Heroin.
HesperetinThe metabolism of Hesperetin can be decreased when combined with Lidocaine.
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Lidocaine.
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Lidocaine.
HyaluronidaseThe risk or severity of adverse effects can be increased when Hyaluronidase is combined with Lidocaine.
HydrocodoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Hydrocodone.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Lidocaine.
HydromorphoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Hydromorphone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
HydroxyzineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Hydroxyzine.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Lidocaine.
IbutilideLidocaine may increase the arrhythmogenic activities of Ibutilide.
IdelalisibThe serum concentration of Lidocaine can be increased when it is combined with Idelalisib.
IloperidoneThe metabolism of Iloperidone can be decreased when combined with Lidocaine.
IloperidoneThe risk or severity of adverse effects can be increased when Iloperidone is combined with Lidocaine.
ImatinibThe metabolism of Lidocaine can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Lidocaine.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Lidocaine.
ImipramineThe metabolism of Lidocaine can be decreased when combined with Imipramine.
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Lidocaine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Lidocaine.
IndalpineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Indalpine.
IndenololThe serum concentration of Lidocaine can be increased when it is combined with Indenolol.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Lidocaine.
IndinavirThe metabolism of Lidocaine can be decreased when combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Lidocaine.
IrbesartanThe metabolism of Lidocaine can be decreased when combined with Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Lidocaine.
IsavuconazoniumThe metabolism of Lidocaine can be decreased when combined with Isavuconazonium.
IsofluraneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Isoflurane.
IsoniazidThe metabolism of Lidocaine can be decreased when combined with Isoniazid.
IsradipineThe metabolism of Lidocaine can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Lidocaine can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Lidocaine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Lidocaine.
IxazomibThe metabolism of Ixazomib can be decreased when combined with Lidocaine.
KetamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Lidocaine.
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Lidocaine.
KetobemidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ketobemidone.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Lidocaine.
KetoconazoleThe metabolism of Lidocaine can be decreased when combined with Ketoconazole.
LabetalolThe serum concentration of Lidocaine can be increased when it is combined with Labetalol.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Lidocaine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Lidocaine.
LamotrigineThe risk or severity of adverse effects can be increased when Lamotrigine is combined with Lidocaine.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Lidocaine.
LapatinibThe metabolism of Lidocaine can be decreased when combined with Lapatinib.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Lidocaine.
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Lidocaine.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Lidocaine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Lidocaine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Lidocaine.
LevetiracetamThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Lidocaine.
LevobunololThe serum concentration of Lidocaine can be increased when it is combined with Levobunolol.
LevobupivacaineThe metabolism of Levobupivacaine can be decreased when combined with Lidocaine.
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Lidocaine.
LevocabastineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Lidocaine.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levomethadyl Acetate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Levorphanol.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Lidocaine.
LithiumThe risk or severity of adverse effects can be increased when Lidocaine is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Lofentanil.
LomefloxacinThe metabolism of Lomefloxacin can be decreased when combined with Lidocaine.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Lidocaine.
LopinavirThe metabolism of Lidocaine can be decreased when combined with Lopinavir.
LoratadineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Lidocaine.
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Lidocaine.
LosartanThe serum concentration of Losartan can be increased when it is combined with Lidocaine.
LosartanThe metabolism of Lidocaine can be decreased when combined with Losartan.
LovastatinThe metabolism of Lidocaine can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Loxapine.
Lu AA21004The risk or severity of adverse effects can be increased when Lidocaine is combined with Lu AA21004.
LuliconazoleThe serum concentration of Lidocaine can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Lidocaine can be decreased when it is combined with Lumacaftor.
LumefantrineThe metabolism of Lidocaine can be decreased when combined with Lumefantrine.
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Lidocaine.
LurasidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Magnesium Sulfate.
MalathionThe metabolism of Malathion can be decreased when combined with Lidocaine.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Lidocaine.
MaprotilineThe metabolism of Maprotiline can be decreased when combined with Lidocaine.
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Lidocaine.
MeclizineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Medetomidine.
MelatoninThe metabolism of Melatonin can be decreased when combined with Lidocaine.
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Lidocaine.
MelperoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Melperone.
MenadioneThe metabolism of Menadione can be decreased when combined with Lidocaine.
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Lidocaine.
MepivacaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Mepivacaine.
MeprobamateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Meprobamate.
MesoridazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Metaxalone.
MethadoneThe metabolism of Methadone can be decreased when combined with Lidocaine.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methohexital.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Lidocaine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methotrimeprazine.
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Lidocaine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Lidocaine.
MethsuximideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Methylphenobarbital.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Lidocaine.
MetipranololThe serum concentration of Lidocaine can be increased when it is combined with Metipranolol.
MetoprololThe serum concentration of Lidocaine can be increased when it is combined with Metoprolol.
MetyrosineLidocaine may increase the sedative activities of Metyrosine.
MexiletineThe metabolism of Mexiletine can be decreased when combined with Lidocaine.
MianserinThe metabolism of Mianserin can be decreased when combined with Lidocaine.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Lidocaine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Lidocaine.
MifepristoneThe metabolism of Lidocaine can be decreased when combined with Mifepristone.
MilnacipranThe risk or severity of adverse effects can be increased when Lidocaine is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Lidocaine.
MirabegronThe metabolism of Lidocaine can be decreased when combined with Mirabegron.
MirtazapineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Lidocaine.
MitotaneThe serum concentration of Lidocaine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Lidocaine.
ModafinilThe serum concentration of Lidocaine can be decreased when it is combined with Modafinil.
MolindoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Molindone.
MorphineThe serum concentration of Morphine can be increased when it is combined with Lidocaine.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Lidocaine.
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Lidocaine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Lidocaine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Lidocaine.
NabiloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nabilone.
NabumetoneThe metabolism of Nabumetone can be decreased when combined with Lidocaine.
NadololThe serum concentration of Lidocaine can be increased when it is combined with Nadolol.
NafcillinThe serum concentration of Lidocaine can be decreased when it is combined with Nafcillin.
NalbuphineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nalbuphine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Lidocaine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Lidocaine.
NaproxenThe metabolism of Naproxen can be decreased when combined with Lidocaine.
NefazodoneThe metabolism of Lidocaine can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Lidocaine can be decreased when combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Lidocaine.
NetupitantThe serum concentration of Lidocaine can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Lidocaine can be decreased when combined with Nevirapine.
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Lidocaine.
NicardipineThe metabolism of Lidocaine can be decreased when combined with Nicardipine.
NicotineThe metabolism of Nicotine can be decreased when combined with Lidocaine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Lidocaine.
NilotinibThe metabolism of Lidocaine can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Lidocaine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Lidocaine.
NitrazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nitrazepam.
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Lidocaine.
Nitric OxideThe metabolism of Nitric Oxide can be decreased when combined with Lidocaine.
Nitrous oxideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Nitrous oxide.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Lidocaine.
NormethadoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Normethadone.
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Lidocaine.
NortriptylineThe risk or severity of adverse effects can be increased when Nortriptyline is combined with Lidocaine.
OlanzapineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Olanzapine.
OlaparibThe metabolism of Lidocaine can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Olopatadine.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Lidocaine.
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Lidocaine.
OndansetronThe metabolism of Ondansetron can be decreased when combined with Lidocaine.
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Lidocaine.
OpiumThe risk or severity of adverse effects can be increased when Lidocaine is combined with Opium.
OrphenadrineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Lidocaine.
OsanetantThe risk or severity of adverse effects can be increased when Lidocaine is combined with Osanetant.
OsimertinibThe serum concentration of Lidocaine can be increased when it is combined with Osimertinib.
OxaliplatinThe metabolism of Oxaliplatin can be decreased when combined with Lidocaine.
OxazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxazepam.
OxprenololThe serum concentration of Lidocaine can be increased when it is combined with Oxprenolol.
OxprenololThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxprenolol.
OxtriphyllineThe metabolism of Oxtriphylline can be decreased when combined with Lidocaine.
OxybuprocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxybuprocaine.
OxycodoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxycodone.
OxymorphoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxymorphone.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Lidocaine.
PalbociclibThe serum concentration of Lidocaine can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Paliperidone.
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Lidocaine.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Lidocaine.
PanobinostatThe metabolism of Lidocaine can be decreased when combined with Panobinostat.
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Lidocaine.
ParaldehydeLidocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Lidocaine.
ParoxetineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Paroxetine.
ParoxetineThe metabolism of Lidocaine can be decreased when combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Lidocaine.
Peginterferon alfa-2bThe serum concentration of Lidocaine can be decreased when it is combined with Peginterferon alfa-2b.
PenbutololThe serum concentration of Lidocaine can be increased when it is combined with Penbutolol.
PentamidineThe metabolism of Pentamidine can be decreased when combined with Lidocaine.
PentazocineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pentobarbital.
PentoxifyllineThe metabolism of Pentoxifylline can be decreased when combined with Lidocaine.
PerampanelThe risk or severity of adverse effects can be increased when Lidocaine is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Perospirone.
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Lidocaine.
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Lidocaine.
PethidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pethidine.
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Lidocaine.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Lidocaine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Lidocaine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Phenoxyethanol.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Lidocaine.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Lidocaine.
PimozideThe metabolism of Pimozide can be decreased when combined with Lidocaine.
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Lidocaine.
PindololThe serum concentration of Lidocaine can be increased when it is combined with Pindolol.
PioglitazoneThe metabolism of Lidocaine can be decreased when combined with Pioglitazone.
PipamperoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pipamperone.
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Lidocaine.
PipotiazineThe risk or severity of adverse effects can be increased when Pipotiazine is combined with Lidocaine.
PirfenidoneThe serum concentration of Pirfenidone can be increased when it is combined with Lidocaine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Lidocaine.
PizotifenThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pizotifen.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Lidocaine.
PomalidomideThe risk or severity of adverse effects can be increased when Pomalidomide is combined with Lidocaine.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Lidocaine.
PosaconazoleThe metabolism of Lidocaine can be decreased when combined with Posaconazole.
PractololThe serum concentration of Lidocaine can be increased when it is combined with Practolol.
PramipexoleLidocaine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Pramocaine.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Lidocaine.
PrazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Prazepam.
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Lidocaine.
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Lidocaine.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Lidocaine.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Lidocaine.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Lidocaine.
PrilocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Prilocaine.
PrimaquineThe metabolism of Primaquine can be decreased when combined with Lidocaine.
PrimidoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Procaine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Prochlorperazine.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Lidocaine.
ProguanilThe metabolism of Proguanil can be decreased when combined with Lidocaine.
PromazineThe metabolism of Promazine can be decreased when combined with Lidocaine.
PromethazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Promethazine.
PropafenoneThe metabolism of Propafenone can be decreased when combined with Lidocaine.
ProparacaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Proparacaine.
PropofolThe metabolism of Propofol can be decreased when combined with Lidocaine.
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Lidocaine.
PropoxycaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Propoxycaine.
PropranololThe serum concentration of Lidocaine can be increased when it is combined with Propranolol.
ProtriptylineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Lidocaine.
PSD502The risk or severity of adverse effects can be increased when Lidocaine is combined with PSD502.
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Lidocaine.
PyrimethamineThe metabolism of Lidocaine can be decreased when combined with Pyrimethamine.
QuazepamThe serum concentration of Lidocaine can be increased when it is combined with Quazepam.
QuazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Quazepam.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Lidocaine.
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Lidocaine.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Lidocaine.
QuinidineThe metabolism of Lidocaine can be decreased when combined with Quinidine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Lidocaine.
QuinineThe metabolism of Lidocaine can be decreased when combined with Quinine.
RabeprazoleThe metabolism of Lidocaine can be decreased when combined with Rabeprazole.
RamelteonThe metabolism of Ramelteon can be decreased when combined with Lidocaine.
RamelteonThe risk or severity of adverse effects can be increased when Ramelteon is combined with Lidocaine.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Lidocaine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Lidocaine.
RanolazineThe metabolism of Lidocaine can be decreased when combined with Ranolazine.
RasagilineThe metabolism of Rasagiline can be decreased when combined with Lidocaine.
RemifentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Remifentanil.
RemoxiprideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Remoxipride.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Lidocaine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Lidocaine.
ResveratrolThe metabolism of Resveratrol can be decreased when combined with Lidocaine.
RifabutinThe metabolism of Lidocaine can be increased when combined with Rifabutin.
RifampicinThe metabolism of Lidocaine can be increased when combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Lidocaine.
RifapentineThe metabolism of Lidocaine can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Lidocaine.
RiluzoleThe metabolism of Riluzole can be decreased when combined with Lidocaine.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Lidocaine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Lidocaine.
RitonavirThe metabolism of Lidocaine can be decreased when combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Lidocaine.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Lidocaine.
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Lidocaine.
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Lidocaine.
RolapitantThe metabolism of Lidocaine can be decreased when combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Lidocaine.
RomifidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Romifidine.
RopiniroleLidocaine may increase the sedative activities of Ropinirole.
RopiniroleThe metabolism of Lidocaine can be decreased when combined with Ropinirole.
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Lidocaine.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Lidocaine.
RosiglitazoneThe metabolism of Lidocaine can be decreased when combined with Rosiglitazone.
RotigotineLidocaine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Lidocaine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Lidocaine is combined with S-Ethylisothiourea.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Lidocaine.
SaquinavirSaquinavir may increase the arrhythmogenic activities of Lidocaine.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Lidocaine.
ScopolamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Secobarbital.
SelegilineThe metabolism of Selegiline can be decreased when combined with Lidocaine.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Lidocaine.
SertindoleThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sertraline.
SertralineThe metabolism of Lidocaine can be decreased when combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sevoflurane.
SildenafilThe metabolism of Lidocaine can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Lidocaine.
SiltuximabThe serum concentration of Lidocaine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Lidocaine can be increased when it is combined with Simeprevir.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Lidocaine.
Sodium NitriteThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sodium Nitrite.
Sodium oxybateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sodium oxybate.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Lidocaine.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Lidocaine.
SorafenibThe metabolism of Lidocaine can be decreased when combined with Sorafenib.
SotalolThe serum concentration of Lidocaine can be increased when it is combined with Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Lidocaine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Lidocaine.
St. John's WortThe serum concentration of Lidocaine can be decreased when it is combined with St. John's Wort.
StiripentolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sufentanil.
SulfadiazineThe metabolism of Lidocaine can be decreased when combined with Sulfadiazine.
SulfamethoxazoleThe metabolism of Lidocaine can be decreased when combined with Sulfamethoxazole.
SulfisoxazoleThe metabolism of Lidocaine can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Sulpiride.
SuvorexantThe risk or severity of adverse effects can be increased when Lidocaine is combined with Suvorexant.
TacrineThe metabolism of Tacrine can be decreased when combined with Lidocaine.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Lidocaine.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Lidocaine.
TamoxifenThe metabolism of Lidocaine can be decreased when combined with Tamoxifen.
TapentadolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tasimelteon.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Lidocaine.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lidocaine.
Technetium Tc-99m tilmanoceptLidocaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.
TedisamilLidocaine may increase the arrhythmogenic activities of Tedisamil.
TelaprevirThe risk or severity of adverse effects can be increased when Telaprevir is combined with Lidocaine.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Lidocaine.
TelithromycinThe metabolism of Lidocaine can be decreased when combined with Telithromycin.
TemafloxacinThe metabolism of Temafloxacin can be decreased when combined with Lidocaine.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Lidocaine.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Lidocaine.
TenofovirThe metabolism of Lidocaine can be decreased when combined with Tenofovir.
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Lidocaine.
TeriflunomideThe serum concentration of Lidocaine can be decreased when it is combined with Teriflunomide.
TetrabenazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tetrodotoxin.
ThalidomideLidocaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Lidocaine.
TheobromineThe metabolism of Theobromine can be decreased when combined with Lidocaine.
TheophyllineThe metabolism of Lidocaine can be decreased when combined with Theophylline.
ThiabendazoleThe metabolism of Thiabendazole can be decreased when combined with Lidocaine.
ThiamylalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Thiamylal.
ThiopentalThe risk or severity of adverse effects can be increased when Lidocaine is combined with Thiopental.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Lidocaine.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Lidocaine.
ThiotepaThe metabolism of Lidocaine can be decreased when combined with Thiotepa.
ThiothixeneThe metabolism of Thiothixene can be decreased when combined with Lidocaine.
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Lidocaine.
TiagabineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tiagabine.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Lidocaine.
TicagrelorThe metabolism of Lidocaine can be decreased when combined with Ticagrelor.
TiclopidineThe metabolism of Lidocaine can be decreased when combined with Ticlopidine.
TiletamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tiletamine.
TimololThe serum concentration of Lidocaine can be increased when it is combined with Timolol.
TipranavirThe metabolism of Lidocaine can be decreased when combined with Tipranavir.
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Lidocaine.
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Lidocaine.
TocilizumabThe serum concentration of Lidocaine can be decreased when it is combined with Tocilizumab.
TolbutamideThe metabolism of Lidocaine can be decreased when combined with Tolbutamide.
TolcaponeThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tolcapone.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Lidocaine.
TopiramateThe risk or severity of adverse effects can be increased when Lidocaine is combined with Topiramate.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Lidocaine.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Lidocaine.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Lidocaine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe metabolism of Lidocaine can be decreased when combined with Tranylcypromine.
TranylcypromineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Tranylcypromine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Lidocaine.
TrazodoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Trazodone.
TriamtereneThe metabolism of Triamterene can be decreased when combined with Lidocaine.
TriazolamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Triazolam.
TrifluoperazineThe metabolism of Trifluoperazine can be decreased when combined with Lidocaine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Lidocaine.
TriflupromazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Triflupromazine.
TrimethoprimThe metabolism of Lidocaine can be decreased when combined with Trimethoprim.
TrimipramineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Triprolidine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Lidocaine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Lidocaine.
Valproic AcidThe risk or severity of adverse effects can be increased when Lidocaine is combined with Valproic Acid.
ValsartanThe metabolism of Lidocaine can be decreased when combined with Valsartan.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Lidocaine.
VemurafenibThe serum concentration of Lidocaine can be increased when it is combined with Vemurafenib.
VenlafaxineThe metabolism of Lidocaine can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Lidocaine.
VerapamilThe metabolism of Lidocaine can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Lidocaine.
VigabatrinThe risk or severity of adverse effects can be increased when Lidocaine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Vilazodone.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Lidocaine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Lidocaine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Lidocaine.
VoriconazoleThe metabolism of Lidocaine can be decreased when combined with Voriconazole.
VortioxetineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Vortioxetine.
WarfarinThe metabolism of Warfarin can be decreased when combined with Lidocaine.
XylazineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Xylazine.
ZafirlukastThe metabolism of Lidocaine can be decreased when combined with Zafirlukast.
ZaleplonThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zaleplon.
ZiconotideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Ziconotide.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Lidocaine.
ZileutonThe metabolism of Zileuton can be decreased when combined with Lidocaine.
ZimelidineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zimelidine.
ZiprasidoneThe metabolism of Lidocaine can be decreased when combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zolazepam.
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Lidocaine.
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Lidocaine.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Lidocaine.
ZonisamideThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Lidocaine is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Gene Name:
SCN10A
Uniprot ID:
Q9Y5Y9
Molecular Weight:
220623.605 Da
References
  1. Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ: muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17030-5. Epub 2006 Oct 31. [PubMed:17077153 ]
  2. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384 ]
  3. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity
Specific Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, es...
Gene Name:
SCN9A
Uniprot ID:
Q15858
Molecular Weight:
226370.175 Da
References
  1. Sheets PL, Jackson JO 2nd, Waxman SG, Dib-Hajj SD, Cummins TR: A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol. 2007 Jun 15;581(Pt 3):1019-31. Epub 2007 Apr 12. [PubMed:17430993 ]
  2. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384 ]
  3. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity involved in sa node cell action potential
Specific Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is respon...
Gene Name:
SCN5A
Uniprot ID:
Q14524
Molecular Weight:
226937.475 Da
References
  1. Itoh H, Tsuji K, Sakaguchi T, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ashihara T, Ito M, Horie M, Imoto K: A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome. Int J Cardiol. 2007 Oct 18;121(3):239-48. Epub 2007 Apr 18. [PubMed:17445919 ]
  2. Fedida D, Orth PM, Hesketh JC, Ezrin AM: The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S71-S78. [PubMed:16686685 ]
  3. Wallace CH, Baczko I, Jones L, Fercho M, Light PE: Inhibition of cardiac voltage-gated sodium channels by grape polyphenols. Br J Pharmacol. 2006 Nov;149(6):657-65. Epub 2006 Oct 3. [PubMed:17016511 ]
  4. Cerne A, Bergh C, Borg K, Ek I, Gejervall AL, Hillensjo T, Olofsson JI, Stener-Victorin E, Wood M, Westlander G: Pre-ovarian block versus paracervical block for oocyte retrieval. Hum Reprod. 2006 Nov;21(11):2916-21. Epub 2006 Jul 13. [PubMed:16840798 ]
  5. Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. doi: 10.1085/jgp.200810103. Epub 2008 Dec 15. [PubMed:19088384 ]
  6. Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. doi: 10.1371/journal.pcbi.1000818. [PubMed:20585544 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Ubiquitin protein ligase binding
Specific Function:
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on ke...
Gene Name:
EGFR
Uniprot ID:
P00533
Molecular Weight:
134276.185 Da
References
  1. Sakaguchi M, Kuroda Y, Hirose M: The antiproliferative effect of lidocaine on human tongue cancer cells with inhibition of the activity of epidermal growth factor receptor. Anesth Analg. 2006 Apr;102(4):1103-7. [PubMed:16551906 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. [PubMed:10901707 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. [PubMed:19754423 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. [PubMed:10901707 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP2C18
Uniprot ID:
P33260
Molecular Weight:
55710.075 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. [PubMed:11743742 ]
  2. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
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Drug created on June 13, 2005 07:24 / Updated on August 30, 2016 02:12