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Identification
NameOxycodone
Accession NumberDB00497  (APRD00387)
TypeSmall Molecule
GroupsApproved, Illicit, Investigational
Description

Oxycodone is a semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. An extended-release (ER) form of oxycodone (Xtampza ER) was approved for the management of daily, around-the-clock pain management in April, 2016.

Structure
Thumb
Synonyms
(-)-14-Hydroxydihydrocodeinone
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
Dihydro-14-hydroxycodeinone
Dihydrohydroxycodeinone
Dihydroxycodeinone
Oxicodona
Oxycodone
Oxycodonum
External Identifiers
  • PTI-821
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Oxycodone CRtablet (extended-release)80 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Act Oxycodone CRtablet (extended-release)40 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Act Oxycodone CRtablet (extended-release)20 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Act Oxycodone CRtablet (extended-release)10 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Act Oxycodone CRtablet (extended-release)5 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Oxaydotablet7.5 mg/1oralEgalet Us Inc.2015-09-01Not applicableUs
Oxaydotablet5 mg/1oralEgalet Us Inc.2015-09-01Not applicableUs
Oxectatablet7.5 mg/1oralPfizer Laboratories Div Pfizer Inc2011-06-17Not applicableUs
Oxectatablet5 mg/1oralPfizer Laboratories Div Pfizer Inc2011-06-17Not applicableUs
Oxy.irtablet5 mgoralPurdue Pharma2000-03-31Not applicableCanada
Oxy.irtablet (immediate release)20 mgoralPurdue Pharma2000-03-31Not applicableCanada
Oxy.irtablet10 mgoralPurdue Pharma2000-03-31Not applicableCanada
Oxycodonetablet20 mgoralPro Doc Limitee2009-06-10Not applicableCanada
Oxycodonetablet10 mgoralPro Doc Limitee2009-06-10Not applicableCanada
Oxycodonetablet5 mgoralPro Doc Limitee2009-06-10Not applicableCanada
Oxycodone HCltablet, film coated, extended release80 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-08Not applicableUs
Oxycodone HCltablet, film coated, extended release40 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-08Not applicableUs
Oxycodone HCl Controlled-releasetablet20 mg/1oralRanbaxy Pharmaceuticals Inc2010-02-01Not applicableUs
Oxycodone HCl Controlled-releasetablet10 mg/1oralRanbaxy Pharmaceuticals Inc2010-02-01Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-12-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release10 mg/1oralPar Pharmaceutical Companies, Inc2010-08-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralSandoz Inc2014-10-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release10 mg/1oralTeva Pharmaceuticals USA Inc2015-10-12Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release30 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralVista Pharm Inc.2012-03-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release20 mg/1oralPar Pharmaceutical Companies, Inc2010-08-08Not applicableUs
Oxycodone Hydrochloridesolution, concentrate20 mg/mLoralSafecor Health, LLC2013-09-23Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release20 mg/1oralSandoz Inc2014-10-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release20 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralVista Pharm Inc.2012-03-15Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralbryant ranch prepack2010-12-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release10 mg/1oralSandoz Inc2014-10-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release15 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralLehigh Valley Technologies, Inc.2010-10-20Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralActavis Pharma, Inc.2014-09-03Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release10 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralLehigh Valley Technologies, Inc.2013-09-09Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralLehigh Valley Technologies, Inc.2010-10-20Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralActavis Pharma, Inc.2014-09-03Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralTeva Pharmaceuticals USA Inc2015-10-12Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralPar Pharmaceutical Companies, Inc2010-08-08Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralbryant ranch prepack2010-12-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralTeva Pharmaceuticals USA Inc2015-10-12Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralPar Pharmaceutical Companies, Inc2010-08-08Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralGlenmark Generics, Inc2010-12-20Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralSandoz Inc2014-10-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release20 mg/1oralTeva Pharmaceuticals USA Inc2015-10-12Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release60 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloride Controlled-releasetablet, extended release80 mg/1oralEthex Corporation2009-09-25Not applicableUs
Oxycodone Hydrochloride Controlled-releasetablet, extended release40 mg/1oralEthex Corporation2009-09-25Not applicableUs
Oxycodone Hydrochloride Controlled-releasetablet, extended release20 mg/1oralEthex Corporation2009-09-25Not applicableUs
Oxycodone Hydrochloride Controlled-releasetablet, extended release10 mg/1oralEthex Corporation2009-09-25Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralSt Marys Medical Park Pharmacy2010-12-30Not applicableUs
Oxycontintablet, film coated, extended release80 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralbryant ranch prepack2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release60 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release60 mg/1oralRebel Distributors Corp2010-08-08Not applicableUs
Oxycontintablet (extended-release)60 mgoralPurdue Pharma2009-05-012012-09-26Canada
Oxycontintablet, film coated, extended release80 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release80 mg/1oralRebel Distributors Corp2010-08-08Not applicableUs
Oxycontintablet (extended-release)30 mgoralPurdue Pharma2009-05-012012-09-26Canada
Oxycontintablet, film coated, extended release60 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralPd Rx Pharmaceuticals, Inc.2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-08Not applicableUs
Oxycontintablet (extended-release)15 mgoralPurdue Pharma2009-05-012012-09-26Canada
Oxycontintablet, film coated, extended release40 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralPd Rx Pharmaceuticals, Inc.1995-12-01Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release30 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet80 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-28Not applicableUs
Oxycontintablet, film coated, extended release40 mg/1oralPd Rx Pharmaceuticals, Inc.1995-12-01Not applicableUs
Oxycontintablet, film coated, extended release60 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-09Not applicableUs
Oxycontintablet, film coated, extended release30 mg/1oralSTAT Rx USA LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release40 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-12-01Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralbryant ranch prepack2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release80 mg/1oralPd Rx Pharmaceuticals, Inc.1997-01-01Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-09Not applicableUs
Oxycontintablet, film coated, extended release80 mg/1oralSTAT Rx USA LLC1997-01-01Not applicableUs
Oxycontintablet, film coated, extended release15 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet20 mg/1oralSTAT Rx USA LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-09Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralSTAT Rx USA LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release40 mg/1oralbryant ranch prepack2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralRebel Distributors Corp2010-08-08Not applicableUs
Oxycontin 10mgtablet (extended-release)10 mgoralPurdue Pharma1996-12-312012-09-26Canada
Oxycontin 20mgtablet (extended-release)20 mgoralPurdue Pharma1996-12-312012-09-26Canada
Oxycontin 40mgtablet (extended-release)40 mgoralPurdue Pharma1996-12-312012-09-26Canada
Oxycontin 5mgtablet (extended-release)5 mgoralPurdue Pharma2005-04-012012-09-26Canada
Oxycontin 80mgtablet (extended-release)80 mgoralPurdue Pharma1996-12-312012-09-26Canada
Oxyneotablet (extended-release)40 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)30 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)15 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)10 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)20 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)80 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)60 mgoralPurdue Pharma2011-09-13Not applicableCanada
PMS-oxycodonetablet10 mgoralPharmascience Inc2008-12-03Not applicableCanada
PMS-oxycodonetablet5 mgoralPharmascience Inc2008-12-03Not applicableCanada
PMS-oxycodonetablet20 mgoralPharmascience Inc2008-12-03Not applicableCanada
PMS-oxycodone CRtablet (extended-release)5 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-oxycodone CRtablet (extended-release)80 mgoralPharmascience Inc2012-11-27Not applicableCanada
PMS-oxycodone CRtablet (extended-release)40 mgoralPharmascience Inc2012-11-27Not applicableCanada
PMS-oxycodone CRtablet (extended-release)20 mgoralPharmascience Inc2012-11-27Not applicableCanada
PMS-oxycodone CRtablet (extended-release)10 mgoralPharmascience Inc2012-11-27Not applicableCanada
PMS-oxycodone CRtablet (extended-release)60 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-oxycodone CRtablet (extended-release)30 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-oxycodone CRtablet (extended-release)15 mgoralPharmascience IncNot applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)80 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)60 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)40 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)20 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)15 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Riva-oxycodone CRtablet (extended-release)80 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-oxycodone CRtablet (extended-release)40 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-oxycodone CRtablet (extended-release)20 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-oxycodone CRtablet (extended-release)10 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Roxicodonetablet15 mg/1oralMallinckrodt, Inc2000-08-31Not applicableUs
Roxicodonetablet5 mg/1oralMallinckrodt, Inc2009-08-26Not applicableUs
Roxicodonetablet30 mg/1oralSTAT Rx USA LLC2000-08-31Not applicableUs
Roxicodonetablet30 mg/1oralMallinckrodt, Inc2000-08-31Not applicableUs
Sandoz Oxycodone CRtablet (extended-release)5 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Oxycodone CRtablet (extended-release)10 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Oxycodone CRtablet (extended-release)80 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Oxycodone CRtablet (extended-release)40 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Oxycodone CRtablet (extended-release)20 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Supeudoltablet20 mgoralSandoz Canada Incorporated2005-04-26Not applicableCanada
Supeudol 10tablet10 mgoralSandoz Canada Incorporated1980-12-31Not applicableCanada
Supeudol 10suppository10 mgrectalSandoz Canada Incorporated1973-12-31Not applicableCanada
Supeudol 20suppository20 mgrectalSandoz Canada Incorporated1973-12-31Not applicableCanada
Supeudol 5tablet5 mgoralSandoz Canada Incorporated1990-12-31Not applicableCanada
Teva-oxycodone CRtablet (extended-release)80 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Teva-oxycodone CRtablet (extended-release)40 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Teva-oxycodone CRtablet (extended-release)20 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Teva-oxycodone CRtablet (extended-release)10 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-oxycodone CRtablet (extended-release)5.0 mgoralApotex Inc2012-11-26Not applicableCanada
Apo-oxycodone CRtablet (extended-release)40 mgoralApotex Inc2012-11-26Not applicableCanada
Apo-oxycodone CRtablet (extended-release)60 mgoralApotex Inc2012-11-27Not applicableCanada
Apo-oxycodone CRtablet (extended-release)30 mgoralApotex Inc2012-11-27Not applicableCanada
Apo-oxycodone CRtablet (extended-release)15 mgoralApotex Inc2012-11-27Not applicableCanada
Apo-oxycodone CRtablet (extended-release)80.0 mgoralApotex Inc2012-11-26Not applicableCanada
Apo-oxycodone CRtablet (extended-release)20.0 mgoralApotex Inc2012-11-26Not applicableCanada
Apo-oxycodone CRtablet (extended-release)10.0 mgoralApotex Inc2012-11-26Not applicableCanada
Oxycodone HCltablet15 mg/1oralDIRECT RX2016-02-08Not applicableUs
Oxycodone HCltablet30 mg/1oralDIRECT RX2016-02-22Not applicableUs
Oxycodone Hydchloridetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-12-20Not applicableUs
Oxycodone Hydchloridetablet5 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-20Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralUnit Dose Services2012-12-26Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralMorton Grove Pharmaceuticals, Inc.2015-06-17Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralSun Pharmaceutical Industries, Inc.2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralSTAT Rx USA LLC2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralAmerican Health Packaging2014-09-25Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralAurolife Pharma LLC2012-07-12Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralQualitest Pharmaceuticals2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralQualitest Pharmaceuticals2007-01-31Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralMayne Pharma Inc.2014-06-12Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralMylan Pharmaceuticals Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralEpic Pharma, LLC2015-09-22Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralRoxane Laboratories, Inc.2015-02-02Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralUnit Dose Services2012-12-26Not applicableUs
Oxycodone Hydrochloridesolution20 mg/mLoralGAVIS Pharmaceuticals, LLC2015-07-01Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralSun Pharmaceutical Industries, Inc.2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralPhysicians Total Care, Inc.2008-06-06Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralbryant ranch prepack2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAmerican Health Packaging2009-12-09Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralAurolife Pharma LLC2012-07-12Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralBlenheim Pharmacal, Inc.2010-04-06Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralMayne Pharma Inc.2012-07-31Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralQualitest Pharmaceuticals2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMylan Pharmaceuticals Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralEpic Pharma, LLC2015-09-22Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralUnit Dose Services2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralSun Pharmaceutical Industries, Inc.2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralPhysicians Total Care, Inc.2008-10-01Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralbryant ranch prepack2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralAmerican Health Packaging2010-01-15Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAurolife Pharma LLC2012-07-12Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralBlenheim Pharmacal, Inc.2010-04-06Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralLannett Company, Inc.2014-08-01Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralActavis Pharma, Inc.2010-12-24Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralEpic Pharma, LLC2015-09-22Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralPhysicians Total Care, Inc.2009-12-18Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralbryant ranch prepack2010-03-08Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralAmerican Health Packaging2010-01-15Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralBlenheim Pharmacal, Inc.2010-06-16Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralLannett Company, Inc.2014-09-10Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralActavis Pharma, Inc.2010-12-24Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralEpic Pharma, LLC2015-09-22Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-19Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralPhysicians Total Care, Inc.2008-01-16Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralbryant ranch prepack2010-03-04Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralSTAT Rx USA LLC2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralMallinckrodt, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralActavis Pharma, Inc.2015-08-03Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralMayne Pharma Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-14Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-11-19Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralPhysicians Total Care, Inc.2008-06-06Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralbryant ranch prepack2009-06-01Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralSTAT Rx USA LLC2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-20Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralAmerican Health Packaging2014-09-25Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralMajor Pharmaceuticals2015-06-01Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralAlvogen, Inc.2011-11-03Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralPd Rx Pharmaceuticals, Inc.2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralPd Rx Pharmaceuticals, Inc.2010-01-01Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralH.J. Harkins Company, Inc.2009-03-02Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralANI Pharmaceuticals, Inc.2015-10-13Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralSTAT Rx USA LLC2007-03-19Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-14Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralVista Pharm, Inc.2012-08-15Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralKvk Tech, Inc.2015-08-20Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralCore Pharma, Llc2009-10-27Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMajor Pharmaceuticals2015-02-05Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralMallinckrodt, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralRoxane Laboratories, Inc.2013-07-15Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralMayne Pharma Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralAlvogen, Inc.2011-11-03Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralPd Rx Pharmaceuticals, Inc.2010-01-01Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralPd Rx Pharmaceuticals, Inc.2010-01-01Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralH.J. Harkins Company, Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralSt Marys Medical Park Pharmacy2011-01-11Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralSun Pharmaceutical Industries, Inc.2012-11-19Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralNovel Laboratories, Inc.2015-08-24Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralRebel Distributors Corp2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralDispensing Solutions, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralCore Pharma, Llc2009-10-27Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralQualitest Pharmaceuticals2015-04-13Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMallinckrodt, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralRoxane Laboratories, Inc.2013-07-16Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMayne Pharma Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAlvogen, Inc.2011-11-03Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralPd Rx Pharmaceuticals, Inc.2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralH.J. Harkins Company, Inc.2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralSt Marys Medical Park Pharmacy2013-01-10Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralSun Pharmaceutical Industries, Inc.2012-11-19Not applicableUs
Oxycodone Hydrochloridesolution20 mg/mLoralNovel Laboratories, Inc.2015-04-29Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralSTAT RX LLC USA2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralDispensing Solutions, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralCore Pharma, Llc2009-10-27Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralQualitest Pharmaceuticals2015-04-13Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMayne Pharma Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralMylan Pharmaceuticals Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralRoxane Laboratories, Inc.2015-01-01Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAvera Mc Kennan Hospital2015-05-15Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
OxanestNot Available
OxyIRNot Available
Brand mixtures
NameLabellerIngredients
Apo-oxycodone/acetApotex Inc
EndocetSTAT Rx USA LLC
EndodanSTAT Rx USA LLC
Ntp-oxycodone AcetaminophenNt Pharma Canada Ltd
Nu-oxycodone/acetNu Pharm Inc
Oxycodone and AcetaminophenRoxane Laboratories, Inc.
Oxycodone and AspirinPhysicians Total Care, Inc.
Oxycodone ApapDIRECT RX
Oxycodone Hydrochloride and AcetaminophenRoxane Laboratories, Inc
Oxycodone Hydrochloride and AspirinMylan Pharmaceuticals Inc.
Oxycodone Hydrochloride and IbuprofenActavis Elizabeth LLC
Oxycodone-acetPro Doc Limitee
Oxycodone/acetSanis Health Inc
Oxycodone/acetaminophenNt Pharma Canada Ltd
PercocetSTAT Rx USA LLC
Percocet-demiBristol Myers Squibb Canada
PercodanEndo Pharmaceuticals Inc
Percodan-demiBristol Myers Squibb Canada
PMS-oxycodone - AcetaminophenPharmascience Inc
PrimlevAkrimax Pharmaceuticals, LLC
Ratio-oxycocetTeva Canada Limited
Ratio-oxycodanTeva Canada Limited
RivacocetLaboratoire Riva Inc
RivacodanLaboratoire Riva Inc
RoxicetRoxane Laboratories, Inc.
Roxicet TabRoxane Labs, Division Of Boehringer Ingelheim
Sandoz Oxycodone/acetaminophenSandoz Canada Incorporated
TarginPurdue Pharma
Xartemis XRMallinckrodt, Inc
XoloxRebel Distributors Corp
Salts
Name/CASStructureProperties
Oxycodone hydrochloride
124-90-3
Thumb
  • InChI Key: MUZQPDBAOYKNLO-RKXJKUSZSA-N
  • Monoisotopic Mass: 351.123735904
  • Average Mass: 351.825
DBSALT000277
Oxycodone terephthalate
ThumbNot applicableDBSALT001326
Categories
UNIICD35PMG570
CAS number76-42-6
WeightAverage: 315.3636
Monoisotopic: 315.147058165
Chemical FormulaC18H21NO4
InChI KeyInChIKey=BRUQQQPBMZOVGD-XFKAJCMBSA-N
InChI
InChI=1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1
IUPAC Name
(1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-one
SMILES
[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1(O)CCC2=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassMorphinans
Sub ClassNot Available
Direct ParentMorphinans
Alternative Parents
Substituents
  • Morphinan
  • Benzylisoquinoline
  • Phenanthrene
  • Isoquinolone
  • Tetralin
  • Benzofuran
  • Anisole
  • Aralkylamine
  • Cyclohexanone
  • Alkyl aryl ether
  • Benzenoid
  • Piperidine
  • Tertiary alcohol
  • Cyclic alcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ketone
  • 1,2-aminoalcohol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.
PharmacodynamicsOxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.
Mechanism of actionOxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Related Articles
AbsorptionWell absorbed with an oral bioavailability of 60% to 87%
Volume of distribution
  • 2.6 L/kg
Protein binding45%
Metabolism

Hepatic

SubstrateEnzymesProduct
Oxycodone
oxymorphoneDetails
Oxycodone
noroxycodoneDetails
Route of eliminationOxycodone and its metabolites are excreted primarily via the kidney.
Half life4.5 hours
Clearance
  • 0.8 L/min [adults]
ToxicitySymptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Oxycodone Action PathwayDrug actionSMP00409
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9924
Blood Brain Barrier+0.9885
Caco-2 permeable+0.7774
P-glycoprotein substrateSubstrate0.8996
P-glycoprotein inhibitor IInhibitor0.539
P-glycoprotein inhibitor IINon-inhibitor0.9122
Renal organic cation transporterNon-inhibitor0.5413
CYP450 2C9 substrateNon-substrate0.822
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7796
CYP450 1A2 substrateNon-inhibitor0.9327
CYP450 2C9 inhibitorNon-inhibitor0.9431
CYP450 2D6 inhibitorNon-inhibitor0.5131
CYP450 2C19 inhibitorNon-inhibitor0.882
CYP450 3A4 inhibitorNon-inhibitor0.8714
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9691
Ames testNon AMES toxic0.7337
CarcinogenicityNon-carcinogens0.9557
BiodegradationNot ready biodegradable0.9746
Rat acute toxicity3.0638 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9402
hERG inhibition (predictor II)Non-inhibitor0.9279
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Mallinckrodt inc
  • Purdue pharma lp
  • Roxane laboratories inc
  • Actavis totowa llc
  • Avanthi inc
  • Corepharma llc
  • Kv pharmaceutical co
  • Sun pharmaceutical industries inc
  • Tyco healthcare mallinckrodt
  • Vintage pharmaceuticals inc
  • Xanodyne pharmaceuticals inc
  • Endo Pharmaceuticals
Packagers
Dosage forms
FormRouteStrength
Tablet (extended-release)oral5 mg
Tablet (extended-release)oral10.0 mg
Tablet (extended-release)oral20.0 mg
Tablet (extended-release)oral40 mg
Tablet (extended-release)oral5.0 mg
Tablet (extended-release)oral80.0 mg
Tabletoral7.5 mg/1
Tablet (immediate release)oral20 mg
Capsule, gelatin coatedoral
Tabletoral
Capsuleoral5 mg/1
Solutionoral100 mg/5mL
Solutionoral20 mg/mL
Solutionoral5 mg/5mL
Solution, concentrateoral20 mg/mL
Tabletoral10 mg/1
Tabletoral15 mg/1
Tabletoral20 mg/1
Tabletoral30 mg/1
Tabletoral5 mg/1
Tablet, film coated, extended releaseoral10 mg/1
Tablet, film coated, extended releaseoral20 mg/1
Tablet, film coated, extended releaseoral40 mg/1
Tablet, film coated, extended releaseoral80 mg/1
Capsuleoral
Tablet, film coatedoral
Tablet, extended releaseoral10 mg/1
Tablet, extended releaseoral20 mg/1
Tablet, extended releaseoral40 mg/1
Tablet, extended releaseoral80 mg/1
Tabletoral80 mg/1
Tablet, film coated, extended releaseoral15 mg/1
Tablet, film coated, extended releaseoral30 mg/1
Tablet, film coated, extended releaseoral60 mg/1
Tablet (extended-release)oral15 mg
Tablet (extended-release)oral30 mg
Tablet (extended-release)oral60 mg
Tablet (extended-release)oral10 mg
Tablet (extended-release)oral20 mg
Tablet (extended-release)oral80 mg
Solutionoral
Tabletoral20 mg
Suppositoryrectal10 mg
Tabletoral10 mg
Suppositoryrectal20 mg
Tabletoral5 mg
Tablet (extended-release)oral
Tablet, coatedoral
Prices
Unit descriptionCostUnit
Oxycodone hcl powder53.64USD g
Roxicodone 5 mg/5ml Solution 500ml Bottle53.0USD bottle
Roxicodone 20 mg/ml Concentrate 30ml Bottle46.99USD bottle
OxyCODONE HCl 20 mg/ml Concentrate 30ml Bottle33.99USD bottle
Oxycontin 60 mg tablet17.08USD tablet
OxyCONTIN 80 mg 12 Hour tablet14.36USD tablet
Oxycontin 20 mg tablet11.87USD tablet
Oxycontin 80 mg tablet11.53USD tablet
OxyCONTIN 60 mg 12 Hour tablet10.57USD tablet
Oxycontin 40 mg tablet9.45USD tablet
OxyCODONE HCl 80 mg 12 Hour tablet8.33USD tablet
OxyCONTIN 40 mg 12 Hour tablet7.68USD tablet
Oxycontin 10 mg tablet6.89USD tablet
Oxycontin 30 mg tablet6.59USD tablet
OxyCONTIN 30 mg 12 Hour tablet5.8USD tablet
Roxicodone 30 mg tablet5.19USD tablet
Oxycontin 80 mg Sustained-Release Tablet4.69USD tablet
OxyCODONE HCl 40 mg 12 Hour tablet4.38USD tablet
OxyCONTIN 20 mg 12 Hour tablet4.27USD tablet
Oxycontin 60 mg Sustained-Release Tablet3.55USD tablet
Oxycontin 15 mg tablet3.22USD tablet
Supeudol 20 mg Suppository2.95USD suppository
Roxicodone 15 mg tablet2.83USD tablet
Oxycodone hcl 10 mg tablet2.82USD tablet
Endocet 10-650 mg tablet2.7USD tablet
Endocet 7.5-325 mg tablet2.54USD tablet
Oxycontin 40 mg Sustained-Release Tablet2.54USD tablet
OxyCONTIN 10 mg 12 Hour tablet2.53USD tablet
Supeudol 10 mg Suppository2.33USD suppository
Roxicodone intensol 20 mg/ml2.3USD ml
Endocet 7.5-500 mg tablet2.22USD tablet
Oxycodone-apap 2.5-325 mg tablet2.05USD tablet
Percodan 4.5-0.38-325 mg tablet1.98USD tablet
Oxycontin 30 mg Sustained-Release Tablet1.96USD tablet
Endocet 10-325 mg tablet1.87USD tablet
Endocet 5-325 tablet1.82USD tablet
Percodan tablet1.62USD tablet
Oxycontin 20 mg Sustained-Release Tablet1.46USD tablet
Dazidox 20 mg tablet1.44USD tablet
Oxycodone hcl 30 mg tablet1.41USD tablet
Oxycontin 15 mg Sustained-Release Tablet1.19USD tablet
Endodan 4.83-325 mg tablet1.18USD tablet
Oxycodone hcl 20 mg tablet1.1USD tablet
Oxycontin 10 mg Sustained-Release Tablet0.98USD tablet
Oxycodone hcl 15 mg tablet0.9USD tablet
Oxycodone hcl 5 mg tablet0.81USD tablet
Dazidox 10 mg tablet0.75USD tablet
Oxy-Ir 20 mg Tablet0.74USD tablet
OxyCODONE HCl 5 mg capsule0.71USD capsule
Oxycontin 5 mg Sustained-Release Tablet0.7USD tablet
Endocet 5-325 mg tablet0.6USD tablet
Roxicodone 5 mg tablet0.56USD tablet
Oxyir 5 mg capsule0.52USD capsule
Oxy-Ir 10 mg Tablet0.43USD tablet
Pms-Oxycodone 20 mg Tablet0.42USD tablet
Supeudol 20 mg Tablet0.42USD tablet
Oxycodone 5 mg tablet0.36USD tablet
Pms-Oxycodone 10 mg Tablet0.24USD tablet
Supeudol 10 mg Tablet0.24USD tablet
Pms-Oxycodone 5 mg Tablet0.14USD tablet
Supeudol 5 mg Tablet0.14USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2098738 No1999-08-172012-11-25Canada
US5508042 No1993-04-162013-04-16Us
US6277384 No1998-12-222018-12-22Us
US6488962 No2000-06-202020-06-20Us
US6488963 No1997-06-242017-06-24Us
US6696066 No1998-12-222018-12-22Us
US7201920 No2005-03-162025-03-16Us
US7510726 No2003-11-262023-11-26Us
US7674799 No2005-03-302025-03-30Us
US7674800 No2005-03-302025-03-30Us
US7683072 No2005-03-302025-03-30Us
US7776314 No2005-04-192025-04-19Us
US7976870 No2007-06-012027-06-01Us
US7981439 No2003-11-262023-11-26Us
US8114383 No2004-10-102024-10-10Us
US8309060 No2003-11-202023-11-20Us
US8337888 No2002-08-062022-08-06Us
US8372432 No2009-03-112029-03-11Us
US8377453 No2009-11-192029-11-19Us
US8394408 No2009-03-112029-03-11Us
US8409616 No2003-11-262023-11-26Us
US8597681 No2010-12-212030-12-21Us
US8637540 No2003-11-262023-11-26Us
US8658631 No2012-05-162032-05-16Us
US8668929 No2009-03-112029-03-11Us
US8673355 No1998-12-222018-12-22Us
US8741885 No2012-05-162032-05-16Us
US8808741 No2007-08-242027-08-24Us
US8822487 No1998-12-222018-12-22Us
US8846090 No2003-04-042023-04-04Us
US8846091 No2003-04-042023-04-04Us
US8894987 No2010-03-292030-03-29Us
US8894988 No2007-08-242027-08-24Us
US8969369 No2002-05-102022-05-10Us
US8980319 No2010-12-212030-12-21Us
US8992975 No2012-05-162032-05-16Us
US9050335 No2012-05-162032-05-16Us
US9056051 No2002-05-102022-05-10Us
US9060976 No2002-08-062022-08-06Us
US9073933 No2005-03-302025-03-30Us
US9084729 No2002-05-102022-05-10Us
US9161937 No2002-05-102022-05-10Us
US9168252 No2002-05-102022-05-10Us
US9205082 No2002-05-102022-05-10Us
US9283216 No2002-05-102022-05-10Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point219 °CPhysProp
water solubility100 mg/mlNot Available
logP0.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility5.59 mg/mLALOGPS
logP1.04ALOGPS
logP1.03ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)13.56ChemAxon
pKa (Strongest Basic)8.21ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area59 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity84.04 m3·mol-1ChemAxon
Polarizability32.8 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-014i-6975000000-ecd49efa58246c903e23View in MoNA
References
Synthesis Reference

Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P Christodoulou, “Preparation of oxycodone from codeine.” U.S. Patent US6008355, issued March, 1990.

US6008355
General References
  1. Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed:17525040 ]
  2. Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. [PubMed:18039433 ]
External Links
ATC CodesN02AA05N02AA55
AHFS Codes
  • 28:08.08
PDB EntriesNot Available
FDA labelDownload (689 KB)
MSDSDownload (50.5 KB)
Interactions
Drug Interactions
Drug
AcepromazineAcepromazine may increase the hypotensive activities of Oxycodone.
AcetazolamideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Acetazolamide.
AlvimopanThe risk or severity of adverse effects can be increased when Oxycodone is combined with Alvimopan.
AmilorideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Amiloride.
Ammonium chlorideAmmonium chloride may increase the excretion rate of Oxycodone which could result in a higher serum level.
AmphetamineAmphetamine may increase the analgesic activities of Oxycodone.
AprepitantThe risk or severity of adverse effects can be increased when Aprepitant is combined with Oxycodone.
AtazanavirThe risk or severity of adverse effects can be increased when Atazanavir is combined with Oxycodone.
AzelastineOxycodone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Oxycodone.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Bendroflumethiazide.
BexaroteneThe serum concentration of Oxycodone can be decreased when it is combined with Bexarotene.
BoceprevirThe risk or severity of adverse effects can be increased when Boceprevir is combined with Oxycodone.
BosentanThe serum concentration of Oxycodone can be decreased when it is combined with Bosentan.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
BumetanideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Bumetanide.
ButorphanolButorphanol may decrease the analgesic activities of Oxycodone.
CathinoneCathinone may increase the analgesic activities of Oxycodone.
CeritinibThe risk or severity of adverse effects can be increased when Ceritinib is combined with Oxycodone.
ChlorothiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorothiazide.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorthalidone.
ClarithromycinThe risk or severity of adverse effects can be increased when Clarithromycin is combined with Oxycodone.
CobicistatThe risk or severity of adverse effects can be increased when Cobicistat is combined with Oxycodone.
ConivaptanThe serum concentration of Oxycodone can be increased when it is combined with Conivaptan.
CrizotinibThe risk or severity of adverse effects can be increased when Crizotinib is combined with Oxycodone.
CyclothiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Cyclothiazide.
DabrafenibThe serum concentration of Oxycodone can be decreased when it is combined with Dabrafenib.
DarunavirThe risk or severity of adverse effects can be increased when Darunavir is combined with Oxycodone.
DasatinibThe serum concentration of Oxycodone can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Oxycodone can be decreased when it is combined with Deferasirox.
DelavirdineThe risk or severity of adverse effects can be increased when Delavirdine is combined with Oxycodone.
DesmopressinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Desmopressin.
DiltiazemThe risk or severity of adverse effects can be increased when Diltiazem is combined with Oxycodone.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
DronedaroneThe risk or severity of adverse effects can be increased when Dronedarone is combined with Oxycodone.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
EluxadolineOxycodone may increase the activities of Eluxadoline.
ErythromycinThe risk or severity of adverse effects can be increased when Erythromycin is combined with Oxycodone.
Etacrynic acidThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ethacrynic acid.
EthanolOxycodone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthoxzolamideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ethoxzolamide.
FluconazoleThe risk or severity of adverse effects can be increased when Fluconazole is combined with Oxycodone.
FosamprenavirThe risk or severity of adverse effects can be increased when Fosamprenavir is combined with Oxycodone.
FosaprepitantThe serum concentration of Oxycodone can be increased when it is combined with Fosaprepitant.
FurosemideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Furosemide.
Fusidic AcidThe serum concentration of Oxycodone can be increased when it is combined with Fusidic Acid.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Hydrochlorothiazide.
HydrocodoneOxycodone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Hydroflumethiazide.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
IdelalisibThe serum concentration of Oxycodone can be increased when it is combined with Idelalisib.
ImatinibThe risk or severity of adverse effects can be increased when Imatinib is combined with Oxycodone.
IndapamideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Indapamide.
IndinavirThe risk or severity of adverse effects can be increased when Indinavir is combined with Oxycodone.
IsavuconazoniumThe risk or severity of adverse effects can be increased when Isavuconazonium is combined with Oxycodone.
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Oxycodone.
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Oxycodone.
IvacaftorThe serum concentration of Oxycodone can be increased when it is combined with Ivacaftor.
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Oxycodone.
LinezolidThe risk or severity of adverse effects can be increased when Linezolid is combined with Oxycodone.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxycodone.
LuliconazoleThe serum concentration of Oxycodone can be increased when it is combined with Luliconazole.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
MethotrimeprazineOxycodone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetolazoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Metolazone.
MetyrosineOxycodone may increase the sedative activities of Metyrosine.
MifepristoneThe serum concentration of Oxycodone can be increased when it is combined with Mifepristone.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
MirtazapineOxycodone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MitotaneThe serum concentration of Oxycodone can be decreased when it is combined with Mitotane.
MoclobemideThe risk or severity of adverse effects can be increased when Moclobemide is combined with Oxycodone.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
NaltrexoneThe therapeutic efficacy of Oxycodone can be decreased when used in combination with Naltrexone.
NefazodoneThe risk or severity of adverse effects can be increased when Nefazodone is combined with Oxycodone.
NelfinavirThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Oxycodone.
NilotinibThe risk or severity of adverse effects can be increased when Nilotinib is combined with Oxycodone.
OrphenadrineOxycodone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
PalbociclibThe serum concentration of Oxycodone can be increased when it is combined with Palbociclib.
ParaldehydeOxycodone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineOxycodone may increase the serotonergic activities of Paroxetine.
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Oxycodone.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Oxycodone.
PhenytoinThe metabolism of Oxycodone can be increased when combined with Phenytoin.
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Oxycodone.
PramipexoleOxycodone may increase the sedative activities of Pramipexole.
ProcarbazineThe risk or severity of adverse effects can be increased when Procarbazine is combined with Oxycodone.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Oxycodone.
RamosetronOxycodone may increase the activities of Ramosetron.
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Oxycodone.
RifampicinThe serum concentration of Oxycodone can be decreased when it is combined with Rifampicin.
RitonavirThe risk or severity of adverse effects can be increased when Ritonavir is combined with Oxycodone.
RopiniroleOxycodone may increase the sedative activities of Ropinirole.
RotigotineOxycodone may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Oxycodone.
SaquinavirThe risk or severity of adverse effects can be increased when Saquinavir is combined with Oxycodone.
SelegilineThe risk or severity of adverse effects can be increased when Selegiline is combined with Oxycodone.
SiltuximabThe serum concentration of Oxycodone can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Oxycodone can be increased when it is combined with Simeprevir.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
SpironolactoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Spironolactone.
St. John's WortThe serum concentration of Oxycodone can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Oxycodone can be increased when it is combined with Stiripentol.
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Oxycodone.
SuvorexantOxycodone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
Tedizolid PhosphateThe risk or severity of adverse effects can be increased when Tedizolid Phosphate is combined with Oxycodone.
TelaprevirThe risk or severity of adverse effects can be increased when Telaprevir is combined with Oxycodone.
TelithromycinThe risk or severity of adverse effects can be increased when Telithromycin is combined with Oxycodone.
ThalidomideOxycodone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
TicrynafenThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ticrynafen.
TocilizumabThe serum concentration of Oxycodone can be decreased when it is combined with Tocilizumab.
TorasemideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Torasemide.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Oxycodone.
TriamtereneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Triamterene.
TrichlormethiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Trichlormethiazide.
VerapamilThe risk or severity of adverse effects can be increased when Verapamil is combined with Oxycodone.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Oxycodone.
ZolpidemOxycodone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Take without regard to meals. Avoid alcohol.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed:17525040 ]
  2. Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. [PubMed:18039433 ]
  3. Dietis N, Guerrini R, Calo G, Salvadori S, Rowbotham DJ, Lambert DG: Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile. Br J Anaesth. 2009 Jul;103(1):38-49. doi: 10.1093/bja/aep129. Epub 2009 May 27. [PubMed:19474215 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed:17525040 ]
  2. Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. [PubMed:18039433 ]
  3. Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT: Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain. 2007 Dec 5;132(3):289-300. Epub 2007 Apr 30. [PubMed:17467904 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurot...
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular Weight:
40368.235 Da
References
  1. Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed:17525040 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
4. Kappa-type opioid receptor 2b
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
References
  1. Smith MT: Differences between and combinations of opioids re-visited. Curr Opin Anaesthesiol. 2008 Oct;21(5):596-601. doi: 10.1097/ACO.0b013e32830a4c4a. [PubMed:18784485 ]
Kind
Protein group
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Components:
NameUniProt IDDetails
Alpha-1-acid glycoprotein 1P02763 Details
Alpha-1-acid glycoprotein 2P19652 Details
References
  1. Leow KP, Wright AW, Cramond T, Smith MT: Determination of the serum protein binding of oxycodone and morphine using ultrafiltration. Ther Drug Monit. 1993 Oct;15(5):440-7. [PubMed:8249052 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Lalovic B, Phillips B, Risler LL, Howald W, Shen DD: Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54. [PubMed:15039299 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Lalovic B, Phillips B, Risler LL, Howald W, Shen DD: Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54. [PubMed:15039299 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on May 24, 2016 02:15