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Identification
NameOxycodone
Accession NumberDB00497  (APRD00387)
TypeSmall Molecule
GroupsApproved, Illicit, Investigational
DescriptionOxycodone is a semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. An extended-release (ER) form of oxycodone (Xtampza ER) was approved for the management of daily, around-the-clock pain management in April, 2016.
Structure
Thumb
Synonyms
(-)-14-Hydroxydihydrocodeinone
4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
4,5α-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
Dihydro-14-hydroxycodeinone
Dihydrohydroxycodeinone
Dihydroxycodeinone
Oxicodona
Oxycodone
Oxycodonum
External Identifiers
  • PTI-821
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Oxycodone CRtablet (extended-release)5 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Act Oxycodone CRtablet (extended-release)80 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Act Oxycodone CRtablet (extended-release)10 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Act Oxycodone CRtablet (extended-release)20 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Act Oxycodone CRtablet (extended-release)40 mgoralActavis Pharma Company2012-11-26Not applicableCanada
Oxaydotablet7.5 mg/1oralEgalet Us Inc.2015-09-01Not applicableUs
Oxaydotablet5 mg/1oralEgalet Us Inc.2015-09-01Not applicableUs
Oxectatablet5 mg/1oralPfizer Laboratories Div Pfizer Inc2011-06-17Not applicableUs
Oxectatablet7.5 mg/1oralPfizer Laboratories Div Pfizer Inc2011-06-17Not applicableUs
Oxy.irtablet5 mgoralPurdue Pharma2000-03-31Not applicableCanada
Oxy.irtablet10 mgoralPurdue Pharma2000-03-31Not applicableCanada
Oxy.irtablet (immediate release)20 mgoralPurdue Pharma2000-03-31Not applicableCanada
Oxycodonetablet5 mgoralPro Doc Limitee2009-06-10Not applicableCanada
Oxycodonetablet10 mgoralPro Doc Limitee2009-06-10Not applicableCanada
Oxycodonetablet20 mgoralPro Doc Limitee2009-06-10Not applicableCanada
Oxycodone HCltablet, film coated, extended release40 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-08Not applicableUs
Oxycodone HCltablet, film coated, extended release80 mg/1oralRanbaxy Pharmaceuticals Inc.2010-08-08Not applicableUs
Oxycodone HCl Controlled-releasetablet10 mg/1oralRanbaxy Pharmaceuticals Inc2010-02-01Not applicableUs
Oxycodone HCl Controlled-releasetablet20 mg/1oralRanbaxy Pharmaceuticals Inc2010-02-01Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralVista Pharm Inc.2012-03-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release20 mg/1oralSandoz Inc2014-10-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release30 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release10 mg/1oralTeva Pharmaceuticals USA Inc2015-10-12Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralActavis Pharma, Inc.2014-09-03Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release20 mg/1oralPar Pharmaceutical Companies, Inc2010-08-08Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralLehigh Valley Technologies, Inc.2013-09-09Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralGlenmark Pharmaceuticals Inc., Usa2010-12-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralSandoz Inc2014-10-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralbryant ranch prepack2010-12-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release20 mg/1oralTeva Pharmaceuticals USA Inc2015-10-12Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release10 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralActavis Pharma, Inc.2014-09-03Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralPar Pharmaceutical Companies, Inc2010-08-08Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralAmerican Health Packaging2015-03-31Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralLehigh Valley Technologies, Inc.2010-10-20Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralGlenmark Generics, Inc2010-12-20Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralSandoz Inc2014-10-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release40 mg/1oralTeva Pharmaceuticals USA Inc2015-10-12Not applicableUs
Oxycodone Hydrochloridesolution, concentrate20 mg/mLoralSafecor Health, LLC2013-09-23Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release60 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release15 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralbryant ranch prepack2010-12-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release10 mg/1oralSandoz Inc2014-10-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralPar Pharmaceutical Companies, Inc2010-08-08Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralVista Pharm Inc.2012-03-15Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralTeva Pharmaceuticals USA Inc2015-10-12Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release10 mg/1oralPar Pharmaceutical Companies, Inc2010-08-08Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release80 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralLehigh Valley Technologies, Inc.2010-10-20Not applicableUs
Oxycodone Hydrochloridetablet, film coated, extended release20 mg/1oralImpax Generics2016-02-22Not applicableUs
Oxycodone Hydrochloride Controlled-releasetablet, extended release40 mg/1oralEthex Corporation2009-09-25Not applicableUs
Oxycodone Hydrochloride Controlled-releasetablet, extended release80 mg/1oralEthex Corporation2009-09-25Not applicableUs
Oxycodone Hydrochloride Controlled-releasetablet, extended release10 mg/1oralEthex Corporation2009-09-25Not applicableUs
Oxycodone Hydrochloride Controlled-releasetablet, extended release20 mg/1oralEthex Corporation2009-09-25Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release40 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-12-01Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release40 mg/1oralbryant ranch prepack2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release60 mg/1oralRebel Distributors Corp2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralPd Rx Pharmaceuticals, Inc.1995-12-01Not applicableUs
Oxycontintablet, film coated, extended release80 mg/1oralSTAT Rx USA LLC1997-01-01Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralRebel Distributors Corp2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-09Not applicableUs
Oxycontintablet (extended-release)60 mgoralPurdue Pharma2009-05-012012-09-26Canada
Oxycontintablet, film coated, extended release80 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-08Not applicableUs
Oxycontintablet80 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-28Not applicableUs
Oxycontintablet, film coated, extended release30 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralPd Rx Pharmaceuticals, Inc.2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release30 mg/1oralSTAT Rx USA LLC2010-08-08Not applicableUs
Oxycontintablet20 mg/1oralSTAT Rx USA LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-09Not applicableUs
Oxycontintablet, film coated, extended release60 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-08Not applicableUs
Oxycontintablet (extended-release)15 mgoralPurdue Pharma2009-05-012012-09-26Canada
Oxycontintablet, film coated, extended release40 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralbryant ranch prepack2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release80 mg/1oralPd Rx Pharmaceuticals, Inc.1997-01-01Not applicableUs
Oxycontintablet, film coated, extended release10 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release60 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-06-09Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralSt Marys Medical Park Pharmacy2010-12-30Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralSTAT Rx USA LLC2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release80 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-08Not applicableUs
Oxycontintablet (extended-release)30 mgoralPurdue Pharma2009-05-012012-09-26Canada
Oxycontintablet, film coated, extended release60 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release80 mg/1oralRebel Distributors Corp2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release40 mg/1oralPd Rx Pharmaceuticals, Inc.1995-12-01Not applicableUs
Oxycontintablet, film coated, extended release15 mg/1oralPurdue Pharma LP2010-08-08Not applicableUs
Oxycontintablet, film coated, extended release20 mg/1oralbryant ranch prepack2010-08-08Not applicableUs
Oxycontin 10mgtablet (extended-release)10 mgoralPurdue Pharma1996-12-312012-09-26Canada
Oxycontin 20mgtablet (extended-release)20 mgoralPurdue Pharma1996-12-312012-09-26Canada
Oxycontin 40mgtablet (extended-release)40 mgoralPurdue Pharma1996-12-312012-09-26Canada
Oxycontin 5mgtablet (extended-release)5 mgoralPurdue Pharma2005-04-012012-09-26Canada
Oxycontin 80mgtablet (extended-release)80 mgoralPurdue Pharma1996-12-312012-09-26Canada
Oxyneotablet (extended-release)10 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)60 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)15 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)80 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)30 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)20 mgoralPurdue Pharma2011-09-13Not applicableCanada
Oxyneotablet (extended-release)40 mgoralPurdue Pharma2011-09-13Not applicableCanada
PMS-oxycodonetablet20 mgoralPharmascience Inc2008-12-03Not applicableCanada
PMS-oxycodonetablet5 mgoralPharmascience Inc2008-12-03Not applicableCanada
PMS-oxycodonetablet10 mgoralPharmascience Inc2008-12-03Not applicableCanada
PMS-oxycodone CRtablet (extended-release)40 mgoralPharmascience Inc2012-11-27Not applicableCanada
PMS-oxycodone CRtablet (extended-release)15 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-oxycodone CRtablet (extended-release)80 mgoralPharmascience Inc2012-11-27Not applicableCanada
PMS-oxycodone CRtablet (extended-release)30 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-oxycodone CRtablet (extended-release)10 mgoralPharmascience Inc2012-11-27Not applicableCanada
PMS-oxycodone CRtablet (extended-release)60 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-oxycodone CRtablet (extended-release)20 mgoralPharmascience Inc2012-11-27Not applicableCanada
PMS-oxycodone CRtablet (extended-release)5 mgoralPharmascience IncNot applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)80 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)20 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)40 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)60 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-oxycodone CRtablet (extended-release)15 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Riva-oxycodone CRtablet (extended-release)40 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-oxycodone CRtablet (extended-release)80 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-oxycodone CRtablet (extended-release)10 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Riva-oxycodone CRtablet (extended-release)20 mgoralLaboratoire Riva IncNot applicableNot applicableCanada
Roxicodonetablet5 mg/1oralMallinckrodt, Inc2009-08-26Not applicableUs
Roxicodonetablet15 mg/1oralMallinckrodt, Inc2000-08-31Not applicableUs
Roxicodonetablet30 mg/1oralSTAT Rx USA LLC2000-08-31Not applicableUs
Roxicodonetablet30 mg/1oralMallinckrodt, Inc2000-08-31Not applicableUs
Sandoz Oxycodone CRtablet (extended-release)40 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Oxycodone CRtablet (extended-release)80 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Oxycodone CRtablet (extended-release)10 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Oxycodone CRtablet (extended-release)5 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Sandoz Oxycodone CRtablet (extended-release)20 mgoralSandoz Canada IncorporatedNot applicableNot applicableCanada
Supeudoltablet20 mgoralSandoz Canada Incorporated2005-04-26Not applicableCanada
Supeudol 10tablet10 mgoralSandoz Canada Incorporated1980-12-31Not applicableCanada
Supeudol 10suppository10 mgrectalSandoz Canada Incorporated1973-12-31Not applicableCanada
Supeudol 20suppository20 mgrectalSandoz Canada Incorporated1973-12-31Not applicableCanada
Supeudol 5tablet5 mgoralSandoz Canada Incorporated1990-12-31Not applicableCanada
Teva-oxycodone CRtablet (extended-release)80 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Teva-oxycodone CRtablet (extended-release)10 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Teva-oxycodone CRtablet (extended-release)20 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Teva-oxycodone CRtablet (extended-release)40 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-oxycodone CRtablet (extended-release)5.0 mgoralApotex Inc2012-11-26Not applicableCanada
Apo-oxycodone CRtablet (extended-release)15 mgoralApotex Inc2012-11-27Not applicableCanada
Apo-oxycodone CRtablet (extended-release)10.0 mgoralApotex Inc2012-11-26Not applicableCanada
Apo-oxycodone CRtablet (extended-release)30 mgoralApotex Inc2012-11-27Not applicableCanada
Apo-oxycodone CRtablet (extended-release)20.0 mgoralApotex Inc2012-11-26Not applicableCanada
Apo-oxycodone CRtablet (extended-release)60 mgoralApotex Inc2012-11-27Not applicableCanada
Apo-oxycodone CRtablet (extended-release)40 mgoralApotex Inc2012-11-26Not applicableCanada
Apo-oxycodone CRtablet (extended-release)80.0 mgoralApotex Inc2012-11-26Not applicableCanada
Oxycodone HCltablet15 mg/1oralDIRECT RX2016-02-08Not applicableUs
Oxycodone HCltablet30 mg/1oralDIRECT RX2016-02-22Not applicableUs
Oxycodone Hydchloridetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-12-20Not applicableUs
Oxycodone Hydchloridetablet5 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-20Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralEpic Pharma, LLC2015-09-22Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralBlenheim Pharmacal, Inc.2010-06-16Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-14Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMylan Pharmaceuticals Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralUnit Dose Services2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralbryant ranch prepack2009-06-01Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralDispensing Solutions, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMayne Pharma Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralQualitest Pharmaceuticals2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralRoxane Laboratories, Inc.2015-02-02Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralSTAT Rx USA LLC2007-03-19Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralPhysicians Total Care, Inc.2008-10-01Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAlvogen, Inc.2011-11-03Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralCore Pharma, Llc2009-10-27Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralMallinckrodt, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralSun Pharmaceutical Industries, Inc.2012-11-19Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralH.J. Harkins Company, Inc.2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralbryant ranch prepack2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralAmerican Health Packaging2010-01-15Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralActavis Pharma, Inc.2015-08-03Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralPd Rx Pharmaceuticals, Inc.2010-01-01Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-19Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralSt Marys Medical Park Pharmacy2013-01-10Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralMayne Pharma Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralQualitest Pharmaceuticals2015-04-13Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralSTAT Rx USA LLC2007-01-31Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralVista Pharm, Inc.2012-08-15Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralEpic Pharma, LLC2015-09-22Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralBlenheim Pharmacal, Inc.2010-04-06Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-12-20Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralMylan Pharmaceuticals Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralPd Rx Pharmaceuticals, Inc.2010-01-01Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralSun Pharmaceutical Industries, Inc.2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralUnit Dose Services2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralbryant ranch prepack2010-03-04Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralQualitest Pharmaceuticals2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAurolife Pharma LLC2012-07-12Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralRoxane Laboratories, Inc.2015-01-01Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralSTAT Rx USA LLC2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralPhysicians Total Care, Inc.2008-06-06Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralAlvogen, Inc.2011-11-03Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralMallinckrodt, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralSun Pharmaceutical Industries, Inc.2012-11-19Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralPhysicians Total Care, Inc.2008-06-06Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAmerican Health Packaging2009-12-09Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralActavis Pharma, Inc.2010-12-24Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-11-19Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralSt Marys Medical Park Pharmacy2011-01-11Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralMayne Pharma Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMajor Pharmaceuticals2015-02-05Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralSTAT RX LLC USA2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralSun Pharmaceutical Industries, Inc.2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralH.J. Harkins Company, Inc.2007-01-31Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralbryant ranch prepack2010-03-08Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralAmerican Health Packaging2014-09-25Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralEpic Pharma, LLC2015-09-22Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralBlenheim Pharmacal, Inc.2010-04-06Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralMylan Pharmaceuticals Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralPd Rx Pharmaceuticals, Inc.2007-01-31Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralRoxane Laboratories, Inc.2013-07-16Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralSTAT Rx USA LLC2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralPd Rx Pharmaceuticals, Inc.2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralAlvogen, Inc.2011-11-03Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralAvera Mc Kennan Hospital2015-05-15Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralQualitest Pharmaceuticals2007-01-31Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralAurolife Pharma LLC2012-07-12Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralLannett Company, Inc.2014-09-10Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralPhysicians Total Care, Inc.2008-01-16Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralCore Pharma, Llc2009-10-27Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralAmerican Health Packaging2014-09-25Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralKvk Tech, Inc.2015-08-20Not applicableUs
Oxycodone Hydrochloridesolution20 mg/mLoralNovel Laboratories, Inc.2015-04-29Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralActavis Pharma, Inc.2010-12-24Not applicableUs
Oxycodone Hydrochloridetablet20 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralLake Erie Medical DBA Quality Care Products LLC2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralUnit Dose Services2012-12-26Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralANI Pharmaceuticals, Inc.2015-10-13Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralDispensing Solutions, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralEpic Pharma, LLC2015-09-22Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralMajor Pharmaceuticals2015-06-01Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralRebel Distributors Corp2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMallinckrodt, Inc.2009-07-30Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralSun Pharmaceutical Industries, Inc.2009-05-12Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralH.J. Harkins Company, Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralbryant ranch prepack2009-03-02Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralAmerican Health Packaging2010-01-15Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-05-12Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralRoxane Laboratories, Inc.2013-07-15Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralRhodes Pharmaceuticals L.P.2014-09-08Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralPd Rx Pharmaceuticals, Inc.2010-01-01Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-14Not applicableUs
Oxycodone Hydrochloridesolution5 mg/5mLoralMorton Grove Pharmaceuticals, Inc.2015-06-17Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralAmneal Pharmaceuticals of New York, LLC2012-10-30Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralZydus Pharmaceuticals (USA) Inc.2012-12-26Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralMayne Pharma Inc.2011-02-28Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralQualitest Pharmaceuticals2015-04-13Not applicableUs
Oxycodone Hydrochloridetablet30 mg/1oralAurolife Pharma LLC2012-07-12Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralLannett Company, Inc.2014-08-01Not applicableUs
Oxycodone Hydrochloridesolution20 mg/mLoralGAVIS Pharmaceuticals, LLC2015-07-01Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralGolden State Medical Supply, Inc.2015-09-10Not applicableUs
Oxycodone Hydrochloridetablet5 mg/1oralPhysicians Total Care, Inc.2009-12-18Not applicableUs
Oxycodone Hydrochloridetablet15 mg/1oralCore Pharma, Llc2009-10-27Not applicableUs
Oxycodone Hydrochloridesolution100 mg/5mLoralMayne Pharma Inc.2014-06-12Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralMayne Pharma Inc.2012-07-31Not applicableUs
Oxycodone Hydrochloridetablet10 mg/1oralKvk Tech,Inc2013-10-18Not applicableUs
Oxycodone Hydrochloridecapsule5 mg/1oralNovel Laboratories, Inc.2015-08-24Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
OxanestNot Available
OxyIRNot Available
Brand mixtures
NameLabellerIngredients
Apo-oxycodone/acetApotex Inc
EndocetSTAT Rx USA LLC
EndodanSTAT Rx USA LLC
Ntp-oxycodone AcetaminophenNt Pharma Canada Ltd
Nu-oxycodone/acetNu Pharm Inc
Oxycodone and AcetaminophenRoxane Laboratories, Inc.
Oxycodone and AspirinPhysicians Total Care, Inc.
Oxycodone ApapDIRECT RX
Oxycodone Hydrochloride and AcetaminophenRoxane Laboratories, Inc
Oxycodone Hydrochloride and AspirinMylan Pharmaceuticals Inc.
Oxycodone Hydrochloride and IbuprofenActavis Elizabeth LLC
Oxycodone-acetPro Doc Limitee
Oxycodone/acetSanis Health Inc
Oxycodone/acetaminophenNt Pharma Canada Ltd
PercocetSTAT Rx USA LLC
Percocet-demiBristol Myers Squibb Canada
PercodanEndo Pharmaceuticals Inc
Percodan-demiBristol Myers Squibb Canada
PMS-oxycodone - AcetaminophenPharmascience Inc
PrimlevAkrimax Pharmaceuticals, LLC
Ratio-oxycocetTeva Canada Limited
Ratio-oxycodanTeva Canada Limited
RivacocetLaboratoire Riva Inc
RivacodanLaboratoire Riva Inc
RoxicetRoxane Laboratories, Inc.
Roxicet TabRoxane Labs, Division Of Boehringer Ingelheim
Sandoz Oxycodone/acetaminophenSandoz Canada Incorporated
TarginPurdue Pharma
Xartemis XRMallinckrodt, Inc
XoloxRebel Distributors Corp
Salts
Name/CASStructureProperties
Oxycodone hydrochloride
124-90-3
Thumb
  • InChI Key: MUZQPDBAOYKNLO-RKXJKUSZSA-N
  • Monoisotopic Mass: 351.123735904
  • Average Mass: 351.825
DBSALT000277
Oxycodone terephthalate
ThumbNot applicableDBSALT001326
Categories
UNIICD35PMG570
CAS number76-42-6
WeightAverage: 315.3636
Monoisotopic: 315.147058165
Chemical FormulaC18H21NO4
InChI KeyInChIKey=BRUQQQPBMZOVGD-XFKAJCMBSA-N
InChI
InChI=1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1
IUPAC Name
(1S,5R,13R,17S)-17-hydroxy-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10-trien-14-one
SMILES
[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1(O)CCC2=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassMorphinans
Sub ClassNot Available
Direct ParentMorphinans
Alternative Parents
Substituents
  • Morphinan
  • Benzylisoquinoline
  • Phenanthrene
  • Isoquinolone
  • Tetralin
  • Benzofuran
  • Anisole
  • Aralkylamine
  • Cyclohexanone
  • Alkyl aryl ether
  • Benzenoid
  • Piperidine
  • Tertiary alcohol
  • Cyclic alcohol
  • Tertiary aliphatic amine
  • Tertiary amine
  • Ketone
  • 1,2-aminoalcohol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of diarrhoea, pulmonary oedema and for the relief of moderate to moderately severe pain.
PharmacodynamicsOxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.
Mechanism of actionOxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Related Articles
AbsorptionWell absorbed with an oral bioavailability of 60% to 87%
Volume of distribution
  • 2.6 L/kg
Protein binding45%
Metabolism

Hepatic

SubstrateEnzymesProduct
Oxycodone
oxymorphoneDetails
Oxycodone
noroxycodoneDetails
Route of eliminationOxycodone and its metabolites are excreted primarily via the kidney.
Half life4.5 hours
Clearance
  • 0.8 L/min [adults]
ToxicitySymptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Oxycodone Action PathwayDrug actionSMP00409
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9924
Blood Brain Barrier+0.9885
Caco-2 permeable+0.7774
P-glycoprotein substrateSubstrate0.8996
P-glycoprotein inhibitor IInhibitor0.539
P-glycoprotein inhibitor IINon-inhibitor0.9122
Renal organic cation transporterNon-inhibitor0.5413
CYP450 2C9 substrateNon-substrate0.822
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7796
CYP450 1A2 substrateNon-inhibitor0.9327
CYP450 2C9 inhibitorNon-inhibitor0.9431
CYP450 2D6 inhibitorNon-inhibitor0.5131
CYP450 2C19 inhibitorNon-inhibitor0.882
CYP450 3A4 inhibitorNon-inhibitor0.8714
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9691
Ames testNon AMES toxic0.7337
CarcinogenicityNon-carcinogens0.9557
BiodegradationNot ready biodegradable0.9746
Rat acute toxicity3.0638 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9402
hERG inhibition (predictor II)Non-inhibitor0.9279
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Mallinckrodt inc
  • Purdue pharma lp
  • Roxane laboratories inc
  • Actavis totowa llc
  • Avanthi inc
  • Corepharma llc
  • Kv pharmaceutical co
  • Sun pharmaceutical industries inc
  • Tyco healthcare mallinckrodt
  • Vintage pharmaceuticals inc
  • Xanodyne pharmaceuticals inc
  • Endo Pharmaceuticals
Packagers
Dosage forms
FormRouteStrength
Tablet (extended-release)oral5 mg
Tablet (extended-release)oral10.0 mg
Tablet (extended-release)oral20.0 mg
Tablet (extended-release)oral40 mg
Tablet (extended-release)oral5.0 mg
Tablet (extended-release)oral80.0 mg
Tabletoral7.5 mg/1
Tablet (immediate release)oral20 mg
Capsule, gelatin coatedoral
Tabletoral
Capsuleoral5 mg/1
Solutionoral100 mg/5mL
Solutionoral20 mg/mL
Solutionoral5 mg/5mL
Solution, concentrateoral20 mg/mL
Tabletoral10 mg/1
Tabletoral15 mg/1
Tabletoral20 mg/1
Tabletoral30 mg/1
Tabletoral5 mg/1
Tablet, film coated, extended releaseoral10 mg/1
Tablet, film coated, extended releaseoral20 mg/1
Tablet, film coated, extended releaseoral40 mg/1
Tablet, film coated, extended releaseoral80 mg/1
Capsuleoral
Tablet, film coatedoral
Tablet, extended releaseoral10 mg/1
Tablet, extended releaseoral20 mg/1
Tablet, extended releaseoral40 mg/1
Tablet, extended releaseoral80 mg/1
Tabletoral80 mg/1
Tablet, film coated, extended releaseoral15 mg/1
Tablet, film coated, extended releaseoral30 mg/1
Tablet, film coated, extended releaseoral60 mg/1
Tablet (extended-release)oral15 mg
Tablet (extended-release)oral30 mg
Tablet (extended-release)oral60 mg
Tablet (extended-release)oral10 mg
Tablet (extended-release)oral20 mg
Tablet (extended-release)oral80 mg
Solutionoral
Tabletoral20 mg
Suppositoryrectal10 mg
Tabletoral10 mg
Suppositoryrectal20 mg
Tabletoral5 mg
Tablet (extended-release)oral
Tablet, coatedoral
Prices
Unit descriptionCostUnit
Oxycodone hcl powder53.64USD g
Roxicodone 5 mg/5ml Solution 500ml Bottle53.0USD bottle
Roxicodone 20 mg/ml Concentrate 30ml Bottle46.99USD bottle
OxyCODONE HCl 20 mg/ml Concentrate 30ml Bottle33.99USD bottle
Oxycontin 60 mg tablet17.08USD tablet
OxyCONTIN 80 mg 12 Hour tablet14.36USD tablet
Oxycontin 20 mg tablet11.87USD tablet
Oxycontin 80 mg tablet11.53USD tablet
OxyCONTIN 60 mg 12 Hour tablet10.57USD tablet
Oxycontin 40 mg tablet9.45USD tablet
OxyCODONE HCl 80 mg 12 Hour tablet8.33USD tablet
OxyCONTIN 40 mg 12 Hour tablet7.68USD tablet
Oxycontin 10 mg tablet6.89USD tablet
Oxycontin 30 mg tablet6.59USD tablet
OxyCONTIN 30 mg 12 Hour tablet5.8USD tablet
Roxicodone 30 mg tablet5.19USD tablet
Oxycontin 80 mg Sustained-Release Tablet4.69USD tablet
OxyCODONE HCl 40 mg 12 Hour tablet4.38USD tablet
OxyCONTIN 20 mg 12 Hour tablet4.27USD tablet
Oxycontin 60 mg Sustained-Release Tablet3.55USD tablet
Oxycontin 15 mg tablet3.22USD tablet
Supeudol 20 mg Suppository2.95USD suppository
Roxicodone 15 mg tablet2.83USD tablet
Oxycodone hcl 10 mg tablet2.82USD tablet
Endocet 10-650 mg tablet2.7USD tablet
Endocet 7.5-325 mg tablet2.54USD tablet
Oxycontin 40 mg Sustained-Release Tablet2.54USD tablet
OxyCONTIN 10 mg 12 Hour tablet2.53USD tablet
Supeudol 10 mg Suppository2.33USD suppository
Roxicodone intensol 20 mg/ml2.3USD ml
Endocet 7.5-500 mg tablet2.22USD tablet
Oxycodone-apap 2.5-325 mg tablet2.05USD tablet
Percodan 4.5-0.38-325 mg tablet1.98USD tablet
Oxycontin 30 mg Sustained-Release Tablet1.96USD tablet
Endocet 10-325 mg tablet1.87USD tablet
Endocet 5-325 tablet1.82USD tablet
Percodan tablet1.62USD tablet
Oxycontin 20 mg Sustained-Release Tablet1.46USD tablet
Dazidox 20 mg tablet1.44USD tablet
Oxycodone hcl 30 mg tablet1.41USD tablet
Oxycontin 15 mg Sustained-Release Tablet1.19USD tablet
Endodan 4.83-325 mg tablet1.18USD tablet
Oxycodone hcl 20 mg tablet1.1USD tablet
Oxycontin 10 mg Sustained-Release Tablet0.98USD tablet
Oxycodone hcl 15 mg tablet0.9USD tablet
Oxycodone hcl 5 mg tablet0.81USD tablet
Dazidox 10 mg tablet0.75USD tablet
Oxy-Ir 20 mg Tablet0.74USD tablet
OxyCODONE HCl 5 mg capsule0.71USD capsule
Oxycontin 5 mg Sustained-Release Tablet0.7USD tablet
Endocet 5-325 mg tablet0.6USD tablet
Roxicodone 5 mg tablet0.56USD tablet
Oxyir 5 mg capsule0.52USD capsule
Oxy-Ir 10 mg Tablet0.43USD tablet
Pms-Oxycodone 20 mg Tablet0.42USD tablet
Supeudol 20 mg Tablet0.42USD tablet
Oxycodone 5 mg tablet0.36USD tablet
Pms-Oxycodone 10 mg Tablet0.24USD tablet
Supeudol 10 mg Tablet0.24USD tablet
Pms-Oxycodone 5 mg Tablet0.14USD tablet
Supeudol 5 mg Tablet0.14USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2098738 No1999-08-172012-11-25Canada
US5508042 No1993-04-162013-04-16Us
US6277384 No1998-12-222018-12-22Us
US6488962 No2000-06-202020-06-20Us
US6488963 No1997-06-242017-06-24Us
US6696066 No1998-12-222018-12-22Us
US7201920 No2005-03-162025-03-16Us
US7510726 No2003-11-262023-11-26Us
US7674799 No2005-03-302025-03-30Us
US7674800 No2005-03-302025-03-30Us
US7683072 No2005-03-302025-03-30Us
US7776314 No2005-04-192025-04-19Us
US7976870 No2007-06-012027-06-01Us
US7981439 No2003-11-262023-11-26Us
US8114383 No2004-10-102024-10-10Us
US8309060 No2003-11-202023-11-20Us
US8337888 No2002-08-062022-08-06Us
US8372432 No2009-03-112029-03-11Us
US8377453 No2009-11-192029-11-19Us
US8394408 No2009-03-112029-03-11Us
US8409616 No2003-11-262023-11-26Us
US8597681 No2010-12-212030-12-21Us
US8637540 No2003-11-262023-11-26Us
US8658631 No2012-05-162032-05-16Us
US8668929 No2009-03-112029-03-11Us
US8673355 No1998-12-222018-12-22Us
US8741885 No2012-05-162032-05-16Us
US8808741 No2007-08-242027-08-24Us
US8822487 No1998-12-222018-12-22Us
US8846090 No2003-04-042023-04-04Us
US8846091 No2003-04-042023-04-04Us
US8894987 No2010-03-292030-03-29Us
US8894988 No2007-08-242027-08-24Us
US8969369 No2002-05-102022-05-10Us
US8980319 No2010-12-212030-12-21Us
US8992975 No2012-05-162032-05-16Us
US9050335 No2012-05-162032-05-16Us
US9056051 No2002-05-102022-05-10Us
US9060976 No2002-08-062022-08-06Us
US9073933 No2005-03-302025-03-30Us
US9084729 No2002-05-102022-05-10Us
US9161937 No2002-05-102022-05-10Us
US9168252 No2002-05-102022-05-10Us
US9205082 No2002-05-102022-05-10Us
US9283216 No2002-05-102022-05-10Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point219 °CPhysProp
water solubility100 mg/mlNot Available
logP0.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility5.59 mg/mLALOGPS
logP1.04ALOGPS
logP1.03ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)13.56ChemAxon
pKa (Strongest Basic)8.21ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area59 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity84.04 m3·mol-1ChemAxon
Polarizability32.8 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-014i-6975000000-ecd49efa58246c903e23View in MoNA
References
Synthesis Reference

Bao-Shan Huang, Yansong Lu, Ben-Yi Ji, Aris P Christodoulou, “Preparation of oxycodone from codeine.” U.S. Patent US6008355, issued March, 1990.

US6008355
General References
  1. Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed:17525040 ]
  2. Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. [PubMed:18039433 ]
External Links
ATC CodesN02AA55N02AA05
AHFS Codes
  • 28:08.08
PDB EntriesNot Available
FDA labelDownload (689 KB)
MSDSDownload (50.5 KB)
Interactions
Drug Interactions
Drug
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Oxycodone.
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Oxycodone.
7-NitroindazoleThe risk or severity of adverse effects can be increased when Oxycodone is combined with 7-Nitroindazole.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINEThe risk or severity of adverse effects can be increased when 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE is combined with Oxycodone.
AbirateroneThe metabolism of Oxycodone can be decreased when combined with Abiraterone.
AcepromazineAcepromazine may increase the hypotensive activities of Oxycodone.
AcepromazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Aceprometazine.
AcetazolamideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Acetazolamide.
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Oxycodone.
adipiplonThe risk or severity of adverse effects can be increased when Oxycodone is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Oxycodone is combined with Alfentanil.
AlimemazineAlimemazine may increase the hypotensive activities of Oxycodone.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Oxycodone.
AlvimopanThe risk or severity of adverse effects can be increased when Oxycodone is combined with Alvimopan.
AmilorideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Amiloride.
AmiodaroneThe metabolism of Oxycodone can be decreased when combined with Amiodarone.
AmisulprideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Amitriptyline.
Ammonium chlorideAmmonium chloride may increase the excretion rate of Oxycodone which could result in a higher serum level.
AmobarbitalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Amobarbital.
AmoxapineOxycodone may increase the serotonergic activities of Amoxapine.
AmoxapineThe risk or severity of adverse effects can be increased when Amoxapine is combined with Oxycodone.
AmperozideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Amperozide.
AmphetamineAmphetamine may increase the analgesic activities of Oxycodone.
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Oxycodone.
AprepitantThe serum concentration of Oxycodone can be increased when it is combined with Aprepitant.
AripiprazoleThe risk or severity of adverse effects can be increased when Oxycodone is combined with Aripiprazole.
ArtemetherThe metabolism of Oxycodone can be decreased when combined with Artemether.
ArticaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Asenapine.
AtazanavirThe risk or severity of adverse effects can be increased when Atazanavir is combined with Oxycodone.
AtomoxetineThe metabolism of Oxycodone can be decreased when combined with Atomoxetine.
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Oxycodone.
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Oxycodone.
AzaperoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Azaperone.
AzelastineOxycodone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Oxycodone.
AzosemideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Azosemide.
BaclofenThe risk or severity of adverse effects can be increased when Oxycodone is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Barbital.
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Oxycodone.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Bendroflumethiazide.
BenmoxinThe risk or severity of adverse effects can be increased when Benmoxin is combined with Oxycodone.
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Oxycodone.
BenzocaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Benzocaine.
BenzphetamineBenzphetamine may increase the analgesic activities of Oxycodone.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Oxycodone is combined with Benzyl alcohol.
BetaxololThe metabolism of Oxycodone can be decreased when combined with Betaxolol.
BexaroteneThe serum concentration of Oxycodone can be decreased when it is combined with Bexarotene.
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Oxycodone.
BoceprevirThe risk or severity of adverse effects can be increased when Boceprevir is combined with Oxycodone.
BortezomibThe metabolism of Oxycodone can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Oxycodone can be decreased when it is combined with Bosentan.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Oxycodone is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
BrimonidineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Brotizolam.
BumetanideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Bumetanide.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Oxycodone.
BuprenorphineBuprenorphine may decrease the analgesic activities of Oxycodone.
BuprenorphineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Buprenorphine.
BupropionThe metabolism of Oxycodone can be decreased when combined with Bupropion.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Oxycodone.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Oxycodone.
ButacaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Butalbital.
ButambenThe risk or severity of adverse effects can be increased when Oxycodone is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Butethal.
ButorphanolButorphanol may decrease the analgesic activities of Oxycodone.
ButorphanolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Butorphanol.
Canrenoic acidThe risk or severity of adverse effects can be increased when Oxycodone is combined with Canrenoic acid.
CarbamazepineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Carbamazepine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Oxycodone is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Carisoprodol.
CaroxazoneThe risk or severity of adverse effects can be increased when Caroxazone is combined with Oxycodone.
CelecoxibThe metabolism of Oxycodone can be decreased when combined with Celecoxib.
CeritinibThe serum concentration of Oxycodone can be increased when it is combined with Ceritinib.
CetirizineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Oxycodone.
ChlormezanoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chloroprocaine.
ChloroquineThe metabolism of Oxycodone can be decreased when combined with Chloroquine.
ChlorothiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorothiazide.
ChlorphenamineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorphenamine.
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Oxycodone.
ChlorphentermineChlorphentermine may increase the analgesic activities of Oxycodone.
ChlorpromazineChlorpromazine may increase the hypotensive activities of Oxycodone.
ChlorpromazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorprothixene.
ChlorthalidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorthalidone.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Chlorzoxazone.
CholecalciferolThe metabolism of Oxycodone can be decreased when combined with Cholecalciferol.
CimetidineThe metabolism of Oxycodone can be decreased when combined with Cimetidine.
CinacalcetThe metabolism of Oxycodone can be decreased when combined with Cinacalcet.
CinchocaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Cinchocaine.
CitalopramOxycodone may increase the serotonergic activities of Citalopram.
CitalopramThe metabolism of Oxycodone can be decreased when combined with Citalopram.
ClarithromycinThe risk or severity of adverse effects can be increased when Clarithromycin is combined with Oxycodone.
ClemastineThe metabolism of Oxycodone can be decreased when combined with Clemastine.
ClemastineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clidinium.
ClobazamThe metabolism of Oxycodone can be decreased when combined with Clobazam.
ClobazamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Oxycodone is combined with clomethiazole.
ClomipramineOxycodone may increase the serotonergic activities of Clomipramine.
ClomipramineThe metabolism of Oxycodone can be decreased when combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clorazepate.
ClotrimazoleThe metabolism of Oxycodone can be decreased when combined with Clotrimazole.
ClozapineThe metabolism of Oxycodone can be decreased when combined with Clozapine.
ClozapineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Clozapine.
CobicistatThe serum concentration of Oxycodone can be increased when it is combined with Cobicistat.
CocaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Cocaine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Oxycodone.
ConivaptanThe serum concentration of Oxycodone can be increased when it is combined with Conivaptan.
ConivaptanThe risk or severity of adverse effects can be increased when Oxycodone is combined with Conivaptan.
CrizotinibThe metabolism of Oxycodone can be decreased when combined with Crizotinib.
CyclizineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Cyclobenzaprine.
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Oxycodone.
CyclosporineThe metabolism of Oxycodone can be decreased when combined with Cyclosporine.
CyclothiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Cyclothiazide.
CyproheptadineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Cyproheptadine.
DabrafenibThe serum concentration of Oxycodone can be decreased when it is combined with Dabrafenib.
DantroleneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Oxycodone.
DapoxetineOxycodone may increase the serotonergic activities of Dapoxetine.
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Oxycodone.
DarunavirThe serum concentration of Oxycodone can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Oxycodone can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Oxycodone can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Oxycodone can be decreased when combined with Delavirdine.
deramciclaneThe risk or severity of adverse effects can be increased when Oxycodone is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Desflurane.
DesipramineThe metabolism of Oxycodone can be decreased when combined with Desipramine.
DesipramineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Desloratadine is combined with Oxycodone.
DesmopressinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Desmopressin.
DetomidineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Detomidine.
DexamethasoneThe serum concentration of Oxycodone can be decreased when it is combined with Dexamethasone.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dexbrompheniramine.
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Oxycodone.
DexmedetomidineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dexmedetomidine.
DextroamphetamineDextroamphetamine may increase the analgesic activities of Oxycodone.
DextromoramideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dextropropoxyphene.
DezocineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dezocine.
DiazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Diazepam.
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Oxycodone.
DifenoxinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dihydrocodeine.
DihydroergotamineThe metabolism of Oxycodone can be decreased when combined with Dihydroergotamine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dihydromorphine.
DiltiazemThe metabolism of Oxycodone can be decreased when combined with Diltiazem.
DimenhydrinateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dimenhydrinate.
DiphenhydramineThe metabolism of Oxycodone can be decreased when combined with Diphenhydramine.
DiphenhydramineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Diphenoxylate.
DoramectinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Doxepin.
DoxycyclineThe metabolism of Oxycodone can be decreased when combined with Doxycycline.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
DoxylamineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Oxycodone is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
DronedaroneThe metabolism of Oxycodone can be decreased when combined with Dronedarone.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Oxycodone.
DrospirenoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Drospirenone.
DrotebanolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Drotebanol.
DuloxetineThe metabolism of Oxycodone can be decreased when combined with Duloxetine.
DyclonineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dyclonine.
EcgonineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Oxycodone is combined with ECGONINE METHYL ESTER.
EfavirenzThe serum concentration of Oxycodone can be decreased when it is combined with Efavirenz.
EfavirenzThe risk or severity of adverse effects can be increased when Oxycodone is combined with Efavirenz.
EfonidipineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Efonidipine.
EliglustatThe metabolism of Oxycodone can be decreased when combined with Eliglustat.
EluxadolineOxycodone may increase the constipating activities of Eluxadoline.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Oxycodone.
EntacaponeThe risk or severity of adverse effects can be increased when Oxycodone is combined with Entacapone.
EnzalutamideThe serum concentration of Oxycodone can be decreased when it is combined with Enzalutamide.
EplerenoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Eplerenone.
ErythromycinThe metabolism of Oxycodone can be decreased when combined with Erythromycin.
EscitalopramOxycodone may increase the serotonergic activities of Escitalopram.
Eslicarbazepine acetateThe serum concentration of Oxycodone can be decreased when it is combined with Eslicarbazepine acetate.
EstazolamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Estazolam.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Oxycodone.
Etacrynic acidThe risk or severity of adverse effects can be increased when Oxycodone is combined with Etacrynic acid.
EthanolOxycodone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Oxycodone.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Oxycodone.
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Oxycodone.
EthosuximideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ethotoin.
EthoxzolamideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ethoxzolamide.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Oxycodone.
EtoperidoneOxycodone may increase the serotonergic activities of Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Etorphine.
EtravirineThe serum concentration of Oxycodone can be decreased when it is combined with Etravirine.
EzogabineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fencamfamine.
FenfluramineOxycodone may increase the serotonergic activities of Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fentanyl.
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Oxycodone.
FexofenadineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Flibanserin.
FluconazoleThe metabolism of Oxycodone can be decreased when combined with Fluconazole.
FludiazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Flunitrazepam.
FluoxetineOxycodone may increase the serotonergic activities of Fluoxetine.
FluoxetineThe metabolism of Oxycodone can be decreased when combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Flupentixol.
FluphenazineFluphenazine may increase the hypotensive activities of Oxycodone.
FluphenazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fluphenazine.
FlurazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Flurazepam.
FluspirileneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fluspirilene.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fluticasone Propionate.
FluvoxamineOxycodone may increase the serotonergic activities of Fluvoxamine.
FluvoxamineThe metabolism of Oxycodone can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Oxycodone can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Oxycodone can be increased when it is combined with Fosaprepitant.
FosphenytoinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Fospropofol.
FurazolidoneThe risk or severity of adverse effects can be increased when Furazolidone is combined with Oxycodone.
FurosemideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Furosemide.
Fusidic AcidThe serum concentration of Oxycodone can be increased when it is combined with Fusidic Acid.
GabapentinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Gabapentin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Oxycodone is combined with gabapentin enacarbil.
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Oxycodone.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Oxycodone is combined with Gamma Hydroxybutyric Acid.
GlutethimideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Glutethimide.
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Oxycodone.
GuanfacineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Halazepam.
HaloperidolThe metabolism of Oxycodone can be decreased when combined with Haloperidol.
HaloperidolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Haloperidol.
HalothaneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Heroin.
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Oxycodone.
HexobarbitalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Hexobarbital.
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Oxycodone.
HydracarbazineThe risk or severity of adverse effects can be increased when Hydracarbazine is combined with Oxycodone.
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Hydrochlorothiazide.
HydrocodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Hydrocodone.
HydroflumethiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Hydroflumethiazide.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Oxycodone.
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Oxycodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
HydroxyzineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Hydroxyzine.
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Oxycodone.
IdelalisibThe serum concentration of Oxycodone can be increased when it is combined with Idelalisib.
IloperidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Iloperidone.
ImatinibThe metabolism of Oxycodone can be decreased when combined with Imatinib.
ImipramineThe metabolism of Oxycodone can be decreased when combined with Imipramine.
ImipramineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Imipramine.
IndalpineOxycodone may increase the serotonergic activities of Indalpine.
IndapamideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Indapamide.
IndinavirThe metabolism of Oxycodone can be decreased when combined with Indinavir.
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Oxycodone.
IproclozideThe risk or severity of adverse effects can be increased when Iproclozide is combined with Oxycodone.
IproniazidThe risk or severity of adverse effects can be increased when Iproniazid is combined with Oxycodone.
IsavuconazoniumThe metabolism of Oxycodone can be decreased when combined with Isavuconazonium.
IsocarboxazidThe risk or severity of adverse effects can be increased when Isocarboxazid is combined with Oxycodone.
IsofluraneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Isoflurane.
IsoniazidThe metabolism of Oxycodone can be decreased when combined with Isoniazid.
IsosorbideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Isosorbide.
IsradipineThe metabolism of Oxycodone can be decreased when combined with Isradipine.
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Oxycodone.
IvacaftorThe serum concentration of Oxycodone can be increased when it is combined with Ivacaftor.
KetamineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ketobemidone.
KetoconazoleThe metabolism of Oxycodone can be decreased when combined with Ketoconazole.
KW-3902The risk or severity of adverse effects can be increased when Oxycodone is combined with KW-3902.
LamotrigineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Levobupivacaine.
LevocabastineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Oxycodone is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Levomethadyl Acetate.
LevomilnacipranOxycodone may increase the serotonergic activities of Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Levorphanol.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Oxycodone.
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Oxycodone.
LithiumThe risk or severity of adverse effects can be increased when Oxycodone is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Oxycodone is combined with Lofentanil.
LopinavirThe risk or severity of adverse effects can be increased when Lopinavir is combined with Oxycodone.
LoratadineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Oxycodone.
LorcaserinThe metabolism of Oxycodone can be decreased when combined with Lorcaserin.
LovastatinThe metabolism of Oxycodone can be decreased when combined with Lovastatin.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Oxycodone.
Lu AA21004Oxycodone may increase the serotonergic activities of Lu AA21004.
Lu AA21004The risk or severity of adverse effects can be increased when Lu AA21004 is combined with Oxycodone.
LuliconazoleThe serum concentration of Oxycodone can be increased when it is combined with Luliconazole.
LumefantrineThe metabolism of Oxycodone can be decreased when combined with Lumefantrine.
LurasidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Lurasidone.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Magnesium Sulfate.
MannitolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Mannitol.
MaprotilineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Maprotiline.
MebanazineThe risk or severity of adverse effects can be increased when Mebanazine is combined with Oxycodone.
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Oxycodone.
MeclizineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Oxycodone is combined with Melatonin.
MelperoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Melperone.
MephentermineMephentermine may increase the analgesic activities of Oxycodone.
MepivacaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Mepivacaine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Oxycodone.
MersalylThe risk or severity of adverse effects can be increased when Oxycodone is combined with Mersalyl.
MesoridazineMesoridazine may increase the hypotensive activities of Oxycodone.
MesoridazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Metaxalone.
MethadoneThe metabolism of Oxycodone can be decreased when combined with Methadone.
MethadoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methadone.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methadyl Acetate.
MethamphetamineMethamphetamine may increase the analgesic activities of Oxycodone.
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Oxycodone.
MethapyrileneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methaqualone.
MethazolamideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methazolamide.
MethocarbamolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Oxycodone.
MethotrimeprazineMethotrimeprazine may increase the hypotensive activities of Oxycodone.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methoxyflurane.
MethsuximideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methsuximide.
MethyclothiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methyclothiazide.
Methylene blueMethylene blue may increase the hypotensive activities of Oxycodone.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Methylphenobarbital.
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Oxycodone.
MetolazoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Metolazone.
MetoprololThe metabolism of Oxycodone can be decreased when combined with Metoprolol.
MetyrosineOxycodone may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Midazolam.
MifepristoneThe metabolism of Oxycodone can be decreased when combined with Mifepristone.
MilnacipranOxycodone may increase the serotonergic activities of Milnacipran.
MinaprineThe risk or severity of adverse effects can be increased when Minaprine is combined with Oxycodone.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
MirabegronThe metabolism of Oxycodone can be decreased when combined with Mirabegron.
MirtazapineOxycodone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Oxycodone.
MitotaneThe serum concentration of Oxycodone can be decreased when it is combined with Mitotane.
MoclobemideThe risk or severity of adverse effects can be increased when Moclobemide is combined with Oxycodone.
ModafinilThe serum concentration of Oxycodone can be decreased when it is combined with Modafinil.
MolindoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Molindone.
MoricizineMoricizine may increase the hypotensive activities of Oxycodone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Oxycodone.
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Oxycodone.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
NabiloneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Nabilone.
NafcillinThe serum concentration of Oxycodone can be decreased when it is combined with Nafcillin.
NalbuphineNalbuphine may decrease the analgesic activities of Oxycodone.
NalbuphineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Nalbuphine.
NaltrexoneThe therapeutic efficacy of Oxycodone can be decreased when used in combination with Naltrexone.
NefazodoneThe risk or severity of adverse effects can be increased when Nefazodone is combined with Oxycodone.
NelfinavirThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Oxycodone.
NetupitantThe serum concentration of Oxycodone can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Oxycodone can be decreased when combined with Nevirapine.
NialamideThe risk or severity of adverse effects can be increased when Nialamide is combined with Oxycodone.
NicardipineThe metabolism of Oxycodone can be decreased when combined with Nicardipine.
NilotinibThe metabolism of Oxycodone can be decreased when combined with Nilotinib.
NitrazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Nitrazepam.
Nitrous oxideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Nortriptyline.
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Oxycodone.
OctamoxinThe risk or severity of adverse effects can be increased when Octamoxin is combined with Oxycodone.
OlanzapineOxycodone may increase the serotonergic activities of Olanzapine.
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Oxycodone.
OlaparibThe metabolism of Oxycodone can be decreased when combined with Olaparib.
OlopatadineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ondansetron.
OpiumThe risk or severity of adverse effects can be increased when Oxycodone is combined with Opium.
OrphenadrineOxycodone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Oxycodone.
OsanetantThe risk or severity of adverse effects can be increased when Oxycodone is combined with Osanetant.
OsimertinibThe serum concentration of Oxycodone can be increased when it is combined with Osimertinib.
OxazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Oxazepam.
OxprenololThe risk or severity of adverse effects can be increased when Oxycodone is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Oxybuprocaine.
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Oxycodone.
OxymorphoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Oxymorphone.
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Oxycodone.
PalbociclibThe serum concentration of Oxycodone can be increased when it is combined with Palbociclib.
PaliperidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Paliperidone.
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Oxycodone.
PanobinostatThe metabolism of Oxycodone can be decreased when combined with Panobinostat.
ParaldehydeOxycodone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Oxycodone.
PargylineThe risk or severity of adverse effects can be increased when Pargyline is combined with Oxycodone.
ParoxetineOxycodone may increase the serotonergic activities of Paroxetine.
ParoxetineThe metabolism of Oxycodone can be decreased when combined with Paroxetine.
Peginterferon alfa-2bThe serum concentration of Oxycodone can be decreased when it is combined with Peginterferon alfa-2b.
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Oxycodone.
PentazocinePentazocine may decrease the analgesic activities of Oxycodone.
PentazocineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Pentazocine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Oxycodone.
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Oxycodone.
PerampanelThe risk or severity of adverse effects can be increased when Oxycodone is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Oxycodone is combined with Perospirone.
PerphenazinePerphenazine may increase the hypotensive activities of Oxycodone.
PerphenazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Oxycodone.
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Oxycodone.
PheniprazineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Oxycodone.
PhenobarbitalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Phenobarbital.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Phenoxyethanol.
PhenoxypropazineThe risk or severity of adverse effects can be increased when Phenoxypropazine is combined with Oxycodone.
PhenterminePhentermine may increase the analgesic activities of Oxycodone.
PhenytoinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Phenytoin.
PimozideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Pimozide.
PipamperoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Pipamperone.
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Oxycodone.
PipotiazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Pipotiazine.
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Oxycodone.
PiretanideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Piretanide.
PirlindoleThe risk or severity of adverse effects can be increased when Pirlindole is combined with Oxycodone.
PivhydrazineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Oxycodone.
PizotifenThe risk or severity of adverse effects can be increased when Oxycodone is combined with Pizotifen.
PolythiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Polythiazide.
PomalidomideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Pomalidomide.
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Oxycodone.
PotassiumThe risk or severity of adverse effects can be increased when Oxycodone is combined with Potassium.
Potassium CitrateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Potassium Citrate.
PramipexoleOxycodone may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Oxycodone.
PrilocaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Prilocaine.
PrimidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Procaine.
ProchlorperazineProchlorperazine may increase the hypotensive activities of Oxycodone.
ProchlorperazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Oxycodone.
PromazinePromazine may increase the hypotensive activities of Oxycodone.
PromazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Promazine.
PromethazinePromethazine may increase the hypotensive activities of Oxycodone.
PromethazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Promethazine.
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Oxycodone.
ProparacaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Proparacaine.
PropofolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Propofol.
PropoxycaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Oxycodone is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Quetiapine.
QuinethazoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Quinethazone.
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Oxycodone.
QuinineThe metabolism of Oxycodone can be decreased when combined with Quinine.
RamelteonThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ramelteon.
RamosetronOxycodone may increase the constipating activities of Ramosetron.
RanolazineThe metabolism of Oxycodone can be decreased when combined with Ranolazine.
RasagilineThe risk or severity of adverse effects can be increased when Rasagiline is combined with Oxycodone.
RemifentanilThe risk or severity of adverse effects can be increased when Oxycodone is combined with Remifentanil.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Oxycodone.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Oxycodone.
RifabutinThe metabolism of Oxycodone can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Oxycodone can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Oxycodone can be increased when combined with Rifapentine.
RisperidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Risperidone.
RitonavirThe risk or severity of adverse effects can be increased when Ritonavir is combined with Oxycodone.
RolapitantThe metabolism of Oxycodone can be decreased when combined with Rolapitant.
RomifidineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Romifidine.
RopiniroleOxycodone may increase the sedative activities of Ropinirole.
RopiniroleThe metabolism of Oxycodone can be decreased when combined with Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Oxycodone.
RotigotineOxycodone may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Oxycodone.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Oxycodone is combined with S-Ethylisothiourea.
SafrazineThe risk or severity of adverse effects can be increased when Safrazine is combined with Oxycodone.
SaquinavirThe risk or severity of adverse effects can be increased when Saquinavir is combined with Oxycodone.
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Oxycodone.
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Oxycodone.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Oxycodone.
SelegilineThe risk or severity of adverse effects can be increased when Selegiline is combined with Oxycodone.
SertindoleThe risk or severity of adverse effects can be increased when Oxycodone is combined with Sertindole.
SertralineOxycodone may increase the serotonergic activities of Sertraline.
SertralineThe metabolism of Oxycodone can be decreased when combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Sevoflurane.
SildenafilThe metabolism of Oxycodone can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Oxycodone can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Oxycodone can be increased when it is combined with Simeprevir.
Sodium oxybateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Sodium oxybate.
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Oxycodone.
SpironolactoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Spironolactone.
St. John's WortThe serum concentration of Oxycodone can be decreased when it is combined with St. John's Wort.
StiripentolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Stiripentol.
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Oxycodone.
SufentanilThe risk or severity of adverse effects can be increased when Oxycodone is combined with Sufentanil.
SulfisoxazoleThe metabolism of Oxycodone can be decreased when combined with Sulfisoxazole.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Oxycodone.
SuvorexantThe risk or severity of adverse effects can be increased when Oxycodone is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tasimelteon.
TelaprevirThe risk or severity of adverse effects can be increased when Telaprevir is combined with Oxycodone.
TelithromycinThe risk or severity of adverse effects can be increased when Telithromycin is combined with Oxycodone.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Oxycodone.
TerbinafineThe metabolism of Oxycodone can be decreased when combined with Terbinafine.
TetrabenazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tetrodotoxin.
ThalidomideOxycodone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Oxycodone.
TheobromineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Theobromine.
ThiamylalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Thiamylal.
ThiethylperazineThiethylperazine may increase the hypotensive activities of Oxycodone.
ThiopentalThe risk or severity of adverse effects can be increased when Oxycodone is combined with Thiopental.
ThioridazineThioridazine may increase the hypotensive activities of Oxycodone.
ThioridazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tiagabine.
TiclopidineThe metabolism of Oxycodone can be decreased when combined with Ticlopidine.
TicrynafenThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ticrynafen.
TiletamineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tiletamine.
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Oxycodone.
TipranavirThe metabolism of Oxycodone can be decreased when combined with Tipranavir.
TizanidineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tizanidine.
TocilizumabThe serum concentration of Oxycodone can be decreased when it is combined with Tocilizumab.
TolcaponeThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tolcapone.
ToloxatoneThe risk or severity of adverse effects can be increased when Toloxatone is combined with Oxycodone.
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Oxycodone.
TolvaptanThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tolvaptan.
TopiramateThe risk or severity of adverse effects can be increased when Oxycodone is combined with Topiramate.
TorasemideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Torasemide.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Oxycodone.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe metabolism of Oxycodone can be decreased when combined with Tranylcypromine.
TranylcypromineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Tranylcypromine.
TrazodoneOxycodone may increase the serotonergic activities of Trazodone.
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Oxycodone.
TriamtereneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Triamterene.
TriazolamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Triazolam.
TrichlormethiazideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Trichlormethiazide.
TrifluoperazineTrifluoperazine may increase the hypotensive activities of Oxycodone.
TrifluoperazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Trifluoperazine.
TriflupromazineTriflupromazine may increase the hypotensive activities of Oxycodone.
TriflupromazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Triflupromazine.
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Oxycodone.
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Oxycodone.
TrimipramineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Triprolidine.
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Oxycodone.
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Oxycodone.
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Oxycodone.
UlaritideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ularitide.
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Oxycodone.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Oxycodone.
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Oxycodone.
VenlafaxineThe metabolism of Oxycodone can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Oxycodone can be decreased when combined with Verapamil.
VigabatrinThe risk or severity of adverse effects can be increased when Oxycodone is combined with Vigabatrin.
VilazodoneOxycodone may increase the serotonergic activities of Vilazodone.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Oxycodone.
VortioxetineOxycodone may increase the serotonergic activities of Vortioxetine.
VortioxetineThe risk or severity of adverse effects can be increased when Vortioxetine is combined with Oxycodone.
XylazineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Oxycodone is combined with Zaleplon.
ZiconotideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ziconotide.
ZimelidineOxycodone may increase the serotonergic activities of Zimelidine.
ZiprasidoneThe metabolism of Oxycodone can be decreased when combined with Ziprasidone.
ZiprasidoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Ziprasidone.
ZolazepamThe risk or severity of adverse effects can be increased when Oxycodone is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Oxycodone.
ZonisamideThe risk or severity of adverse effects can be increased when Oxycodone is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Zopiclone.
ZotepineThe risk or severity of adverse effects can be increased when Oxycodone is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Oxycodone is combined with Zuclopenthixol.
Food Interactions
  • Take without regard to meals. Avoid alcohol.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed:17525040 ]
  2. Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. [PubMed:18039433 ]
  3. Dietis N, Guerrini R, Calo G, Salvadori S, Rowbotham DJ, Lambert DG: Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile. Br J Anaesth. 2009 Jul;103(1):38-49. doi: 10.1093/bja/aep129. Epub 2009 May 27. [PubMed:19474215 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed:17525040 ]
  2. Riley J, Eisenberg E, Muller-Schwefe G, Drewes AM, Arendt-Nielsen L: Oxycodone: a review of its use in the management of pain. Curr Med Res Opin. 2008 Jan;24(1):175-92. [PubMed:18039433 ]
  3. Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT: Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain. 2007 Dec 5;132(3):289-300. Epub 2007 Apr 30. [PubMed:17467904 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurot...
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular Weight:
40368.235 Da
References
  1. Ordonez Gallego A, Gonzalez Baron M, Espinosa Arranz E: Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. [PubMed:17525040 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
4. Kappa-type opioid receptor 2b
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
References
  1. Smith MT: Differences between and combinations of opioids re-visited. Curr Opin Anaesthesiol. 2008 Oct;21(5):596-601. doi: 10.1097/ACO.0b013e32830a4c4a. [PubMed:18784485 ]
Kind
Protein group
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Components:
NameUniProt IDDetails
Alpha-1-acid glycoprotein 1P02763 Details
Alpha-1-acid glycoprotein 2P19652 Details
References
  1. Leow KP, Wright AW, Cramond T, Smith MT: Determination of the serum protein binding of oxycodone and morphine using ultrafiltration. Ther Drug Monit. 1993 Oct;15(5):440-7. [PubMed:8249052 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Lalovic B, Phillips B, Risler LL, Howald W, Shen DD: Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54. [PubMed:15039299 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Lalovic B, Phillips B, Risler LL, Howald W, Shen DD: Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54. [PubMed:15039299 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on September 28, 2016 02:35