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Identification
NameNaproxen
Accession NumberDB00788  (APRD01135)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. [PubChem]

Structure
Thumb
Synonyms
(+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(+)-(S)-Naproxen
(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionic acid
(+)-2-(Methoxy-2-naphthyl)-propionsaeure
(+)-Naproxen
(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-(+)-Naproxen
(S)-2-(6-Methoxy-2-naphthyl)propanoic acid
(S)-2-(6-Methoxy-2-naphthyl)propionic acid
(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
(S)-Naproxen
Naprolag
Naproxen
Naproxène
Naproxeno
Naproxenum
External Identifiers
  • RS 3540
  • RS 3650
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Anaproxtablet275 mgoralSyntex Inc.1980-12-311996-09-30Canada
Anaproxtablet275 mgoralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
Anaproxtablet275 mg/1oralGenentech, Inc.1980-09-04Not applicableUs
Anaprox DStablet550 mgoralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
Anaprox DStablet550 mg/1oralGenentech, Inc.1980-09-04Not applicableUs
Anaprox DS Tab 550mgtablet550 mgoralSyntex Inc.1990-12-311996-09-30Canada
Ava-naproxen ECtablet (enteric-coated)250 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-naproxen ECtablet (enteric-coated)500 mgoralAvanstra Inc2011-10-112014-08-21Canada
EC-naprosyntablet, delayed release375 mg/1oralGenentech, Inc.1994-10-14Not applicableUs
EC-naprosyntablet, delayed release500 mg/1oralGenentech, Inc.1994-10-14Not applicableUs
Mylan-naproxen ECtablet (enteric-coated)250 mgoralMylan Pharmaceuticals Ulc2001-03-14Not applicableCanada
Mylan-naproxen ECtablet (enteric-coated)500 mgoralMylan Pharmaceuticals Ulc1999-10-27Not applicableCanada
Mylan-naproxen ECtablet (enteric-coated)375 mgoralMylan Pharmaceuticals Ulc2001-03-14Not applicableCanada
NaprelankitoralVictory Pharma, Inc.2009-10-15Not applicableUs
Naprelantablet (extended-release)500 mgoralAlkermes Inc2007-05-25Not applicableCanada
Naprelantablet, film coated, extended release375 mg/1oralShionogi Inc.1996-04-01Not applicableUs
Naprelantablet (extended-release)375 mgoralAlkermes Inc2007-05-25Not applicableCanada
Naprelantablet, film coated, extended release750 mg/1oralPd Rx Pharmaceuticals, Inc.2008-12-19Not applicableUs
Naprelantablet, film coated, extended release500 mg/1oralVictory Pharma, Inc.1996-01-05Not applicableUs
Naprelantablet, film coated, extended release375 mg/1oralPhysicians Total Care, Inc.2005-08-19Not applicableUs
Naprelantablet, film coated, extended release500 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-29Not applicableUs
Naprelantablet, film coated, extended release750 mg/1oralVictory Pharma, Inc.2008-12-19Not applicableUs
Naprelantablet, film coated, extended release500 mg/1oralRebel Distributors Corp1996-01-05Not applicableUs
Naprelantablet, film coated, extended release375 mg/1oralVictory Pharma, Inc.1996-01-05Not applicableUs
Naprelantablet, film coated, extended release750 mg/1oralALMATICA PHARMA INC.2014-01-17Not applicableUs
Naprelantablet, film coated, extended release375 mg/1oralRebel Distributors Corp1996-01-05Not applicableUs
Naprelantablet, film coated, extended release375 mg/1oralbryant ranch prepack1996-01-05Not applicableUs
Naprelantablet, film coated, extended release500 mg/1oralALMATICA PHARMA INC.2014-01-17Not applicableUs
Naprelantablet, film coated, extended release500 mg/1oralShionogi Inc.1996-04-01Not applicableUs
Naprelantablet, film coated, extended release750 mg/1oralStat Rx USA2008-12-19Not applicableUs
Naprelantablet, film coated, extended release375 mg/1oralALMATICA PHARMA INC.2014-01-17Not applicableUs
Naprelantablet, film coated, extended release750 mg/1oralShionogi Inc.1996-04-01Not applicableUs
Naprosynsuspension125 mg/5mLoralGenentech, Inc.1987-03-23Not applicableUs
Naprosyntablet500 mg/1oralGenentech, Inc.1976-03-11Not applicableUs
Naprosyntablet375 mg/1oralGenentech, Inc.1976-03-11Not applicableUs
Naprosyntablet500 mg/1oralA S Medication Solutions Llc1976-03-11Not applicableUs
Naprosyntablet250 mg/1oralGenentech, Inc.1976-03-11Not applicableUs
Naprosyntablet (enteric-coated)375 mgoralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
Naprosyntablet (enteric-coated)500 mgoralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
Naprosyntablet (extended-release)750 mgoralAtnahs Pharma Uk Limited1995-12-31Not applicableCanada
Naprosyn 250mgtablet250 mgoralSyntex Inc.1975-12-311996-09-30Canada
Naprosyn 250mg Tabletstablet250 mgoralHoffmann La Roche Limited1995-12-312002-01-22Canada
Naprosyn 375mgtablet375 mgoralSyntex Inc.1983-12-311996-09-30Canada
Naprosyn 375mg Tabletstablet375 mgoralHoffmann La Roche Limited1996-12-312001-06-27Canada
Naprosyn 500 Mg Suppositoriessuppository500 mgrectalHoffmann La Roche Limited1996-12-312002-11-18Canada
Naprosyn 500 Mg Tabletstablet500 mgoralHoffmann La Roche Limited1996-12-312002-07-09Canada
Naprosyn E 250mg Tablets - Ecttablet (enteric-coated)250 mgoralHoffmann La Roche Limited1995-12-312014-02-05Canada
Naprosyn E Tab 250mgtablet (enteric-coated)250 mgoralSyntex Inc.1992-12-311996-09-30Canada
Naprosyn E Tab 375mgtablet (enteric-coated)375 mgoralSyntex Inc.1992-12-311996-09-30Canada
Naprosyn E Tab 500mgtablet (enteric-coated)500 mgoralSyntex Inc.1992-12-311996-09-30Canada
Naprosyn Sup 500mgsuppository500 mgrectalSyntex Inc.1984-12-311996-09-30Canada
Naprosyn Sus 25mg/mlsuspension25 mgoralSyntex Inc.1989-12-311996-09-30Canada
Naprosyn-SR Tab 750mgtablet (extended-release)750 mgoralSyntex Inc.1989-12-311996-09-30Canada
Naproxentablet500 mgoralSanis Health Inc2010-06-15Not applicableCanada
Naproxentablet375 mgoralSanis Health Inc2010-06-15Not applicableCanada
Naproxentablet250 mgoralSanis Health Inc2010-06-15Not applicableCanada
Naproxen 125 Tab 125mgtablet125 mgoralPro Doc Limitee1983-12-312009-07-23Canada
Naproxen 250 Tab 250mgtablet250 mgoralPro Doc Limitee1983-12-31Not applicableCanada
Naproxen 500 Tab 500mgtablet500 mgoralPro Doc Limitee1984-12-31Not applicableCanada
Naproxen ECtablet (enteric-coated)500 mgoralSanis Health Inc2010-06-15Not applicableCanada
Naproxen ECtablet (enteric-coated)375 mgoralSanis Health Inc2010-06-15Not applicableCanada
Naproxen ECtablet (enteric-coated)250 mgoralSanis Health Inc2010-06-15Not applicableCanada
Naproxen Sodiumtablet, film coated, extended release375 mg/1oralAlvogen Inc.2015-03-11Not applicableUs
Naproxen Sodiumtablet, film coated, extended release750 mg/1oralAlvogen Inc.2015-03-11Not applicableUs
Naproxen Sodiumtablet275 mgoralSanis Health Inc2010-06-15Not applicableCanada
Naproxen Sodiumtablet, film coated, extended release500 mg/1oralAlvogen Inc.2015-03-11Not applicableUs
Naproxen Sodium DStablet550 mgoralSanis Health Inc2010-06-15Not applicableCanada
Naproxen-375 Tab 375mgtablet375 mgoralPro Doc Limitee1985-12-31Not applicableCanada
Naproxen-NA Df -tab 550mgtablet550 mgoralPro Doc Limitee1999-09-15Not applicableCanada
Naproxen-NA Tab 275mgtablet275 mgoralPro Doc Limitee1995-12-31Not applicableCanada
Novo-naprox Tab 125mgtablet125 mgoralNovopharm Limited1982-12-312005-08-10Canada
Ntp-naproxentablet375 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxentablet250 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxentablet500 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen ECtablet (enteric-coated)250 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen ECtablet (enteric-coated)500 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen ECtablet (enteric-coated)375 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen Sodiumtablet275 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-naproxen Sodium DStablet550 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-napro-NAtablet275 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-napro-NA DStablet550 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-naprox ECtablet (enteric-coated)500 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-naprox ECtablet (enteric-coated)375 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-naprox ECtablet (enteric-coated)250 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-naprox Tab 125mgtablet125 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-naprox Tab 250mgtablet250 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-naprox Tab 375mgtablet375 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Nu-naprox Tab 500mgtablet500 mgoralNu Pharm Inc1990-12-312012-09-04Canada
Pediapharm Naproxen Suspensionsuspension25 mgoralPediapharm Inc1996-12-31Not applicableCanada
PMS-naproxensuppository500 mgrectalPharmascience Inc1993-12-31Not applicableCanada
PMS-naproxen ECtablet (enteric-coated)375 mgoralPharmascience Inc2007-10-01Not applicableCanada
PMS-naproxen ECtablet (enteric-coated)500 mgoralPharmascience Inc2007-10-01Not applicableCanada
Pro-naproxen EC - 375tablet (enteric-coated)375 mgoralPro Doc Limitee2009-10-16Not applicableCanada
Pro-naproxen EC - 500tablet (enteric-coated)500 mgoralPro Doc Limitee2008-07-04Not applicableCanada
Ratio-naproxentablet500 mgoralRatiopharm Inc Division Of Teva Canada Limited1984-12-312006-08-04Canada
Ratio-naproxensuppository500 mgrectalRatiopharm Inc Division Of Teva Canada Limited1993-12-312006-08-04Canada
Ratio-naproxentablet375 mgoralRatiopharm Inc Division Of Teva Canada Limited1984-12-312006-08-04Canada
Ratio-naproxentablet250 mgoralRatiopharm Inc Division Of Teva Canada Limited1984-12-312006-08-04Canada
Ratio-naproxen Etablet (enteric-coated)500 mgoralRatiopharm Inc Division Of Teva Canada LimitedNot applicableNot applicableCanada
Ratio-naproxen Etablet (enteric-coated)375 mgoralRatiopharm Inc Division Of Teva Canada LimitedNot applicableNot applicableCanada
Ratio-naproxen Etablet (enteric-coated)250 mgoralRatiopharm Inc Division Of Teva Canada LimitedNot applicableNot applicableCanada
Rhodiaprox - 500mg/supsuppository500 mgrectalRhodiapharm Inc1997-11-032000-07-28Canada
Riva-naproxentablet500 mgoralLaboratoire Riva Inc1999-09-012013-07-31Canada
Riva-naproxentablet375 mgoralLaboratoire Riva Inc1999-09-012013-07-31Canada
Riva-naproxentablet250 mgoralLaboratoire Riva Inc1999-09-012013-07-31Canada
Riva-naproxen Sodiumtablet275 mgoralLaboratoire Riva Inc2005-07-052013-07-31Canada
Riva-naproxen Sodium DStablet550 mgoralLaboratoire Riva Inc2005-07-052013-07-31Canada
Sab-naproxensuppository500 mgrectalSabex Inc1997-09-052008-08-07Canada
Synflex DS Tab 550mgtablet550 mgoralAltimed Pharma Inc.1993-12-312005-05-27Canada
Synflex Tab 275mgtablet275 mgoralAltimed Pharma Inc.1988-12-312005-05-27Canada
Teva-naproxentablet375 mgoralTeva Canada Limited1984-12-31Not applicableCanada
Teva-naproxentablet500 mgoralTeva Canada Limited1983-12-31Not applicableCanada
Teva-naproxentablet250 mgoralTeva Canada Limited1982-12-31Not applicableCanada
Teva-naproxen ECtablet (enteric-coated)500 mgoralTeva Canada Limited2001-04-02Not applicableCanada
Teva-naproxen ECtablet (enteric-coated)375 mgoralTeva Canada Limited2001-04-02Not applicableCanada
Teva-naproxen ECtablet (enteric-coated)250 mgoralTeva Canada Limited2001-04-02Not applicableCanada
Teva-naproxen Sodiumtablet275 mgoralTeva Canada Limited1988-12-31Not applicableCanada
Teva-naproxen Sodium DStablet550 mgoralTeva Canada Limited1993-12-31Not applicableCanada
Teva-naproxen SRtablet (extended-release)750 mgoralTeva Canada Limited2000-03-012015-12-04Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
All Day Relieftablet220 mg/1oralREMEDYREPACK INC.2015-03-09Not applicableUs
Apo Naproxen Tab 125mgtablet125 mgoralApotex Inc1982-12-31Not applicableCanada
Apo Naproxen Tab 250mgtablet250 mgoralApotex Inc1982-12-31Not applicableCanada
Apo Naproxen Tab 375mgtablet375 mgoralApotex Inc1983-12-31Not applicableCanada
Apo Naproxen Tab 500mgtablet500 mgoralApotex Inc1983-12-31Not applicableCanada
Apo-napro-NA DS Tab 550mgtablet550 mgoralApotex Inc1993-12-31Not applicableCanada
Apo-napro-NA Tab 275mgtablet275 mgoralApotex Inc1989-12-31Not applicableCanada
Apo-naproxen EC Tabletstablet (enteric-coated)500 mgoralApotex Inc2003-04-23Not applicableCanada
Apo-naproxen EC Tabletstablet (enteric-coated)375 mgoralApotex Inc2003-04-23Not applicableCanada
Apo-naproxen EC Tabletstablet (enteric-coated)250 mgoralApotex Inc2003-04-23Not applicableCanada
Apo-naproxen SR Tablets 750mgtablet (extended-release)750 mgoralApotex Inc1999-05-05Not applicableCanada
Comfort Pac With NaproxenkitPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Flanax Naproxentablet500 mg/1oralBelmora LLC2015-08-18Not applicableUs
Good Sense All Day Pain Relieftablet, film coated220 mg/1oralbryant ranch prepack1997-01-14Not applicableUs
Naprosyntablet250 mg/1oralbryant ranch prepack2009-09-01Not applicableUs
Naproxentablet500 mg/1oralLiberty Pharmaceuticals, Inc.2010-02-18Not applicableUs
Naproxentablet, film coated550 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2013-03-01Not applicableUs
Naproxentablet, delayed release500 mg/1oralAidarex Pharmaceuticals LLC1998-07-29Not applicableUs
Naproxentablet375 mg/1oralSTAT Rx USA LLC2004-01-14Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2011-03-08Not applicableUs
Naproxentablet250 mg/1oralUnit Dose Services2010-02-18Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2013-06-24Not applicableUs
Naproxentablet500 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
Naproxentablet500 mg/1oralCardinal Health2009-11-20Not applicableUs
Naproxentablet550 mg/1oralClinical Solutions Wholesale2010-02-18Not applicableUs
Naproxentablet375 mg/1oralContract Pharmacy Services Pa2010-03-19Not applicableUs
Naproxentablet500 mg/1oralMc Kesson Contract Packaging2012-01-25Not applicableUs
Naproxentablet500 mg/1oralClinical Solutions Wholesale, Llc1993-12-22Not applicableUs
Naproxentablet250 mg/1oralMajor Pharmaceuticals2011-02-28Not applicableUs
Naproxentablet250 mg/1oralTeva Pharmaceuticals USA Inc1993-12-22Not applicableUs
Naproxentablet500 mg/1oralMajor Pharmaceuticals2011-02-28Not applicableUs
Naproxentablet500 mg/1oralBlenheim Pharmacal,Inc.2015-05-27Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2012-01-12Not applicableUs
Naproxentablet500 mg/1oralSTAT Rx USA LLC2007-07-01Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2011-06-28Not applicableUs
Naproxentablet500 mg/1oralUnit Dose Services2010-02-18Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2013-07-09Not applicableUs
Naproxentablet375 mg/1oralCardinal Health2010-02-18Not applicableUs
Naproxentablet250 mg/1oralProficient Rx LP2007-07-01Not applicableUs
Naproxentablet250 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
Naproxentablet375 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-02-18Not applicableUs
Naproxentablet375 mg/1oralGlenmark Pharmaceuticals Inc., Usa2007-07-01Not applicableUs
Naproxentablet500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-02-18Not applicableUs
Naproxentablet375 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-07-18Not applicableUs
Naproxentablet, delayed release500 mg/1oralTeva Pharmaceuticals USA Inc1998-07-29Not applicableUs
Naproxentablet250 mg/1oralRebel Distributors Corp2007-07-01Not applicableUs
Naproxentablet250 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Naproxentablet, film coated550 mg/1oralLake Erie Medical DBA Quality Care Products LLC1996-05-14Not applicableUs
Naproxentablet375 mg/1oralPolygen Pharmaceuticals LLC2012-02-01Not applicableUs
Naproxentablet, delayed release500 mg/1oralPd Rx Pharmaceuticals, Inc.2010-09-23Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2015-12-23Not applicableUs
Naproxentablet250 mg/1oralCarilion Materials Management2010-02-18Not applicableUs
Naproxentablet500 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Naproxentablet375 mg/1oralMajor Pharmaceuticals2008-11-08Not applicableUs
Naproxentablet, delayed release375 mg/1oralAidarex Pharmaceuticals LLC1998-07-31Not applicableUs
Naproxentablet250 mg/1oralMedsource Pharmaceuticals2007-07-01Not applicableUs
Naproxentablet500 mg/1oralAv Pak2015-02-05Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2013-07-01Not applicableUs
Naproxentablet375 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
Naproxentablet500 mg/1oralClinical Solutions Wholesale2010-02-18Not applicableUs
Naproxentablet500 mg/1oralProficient Rx LP2007-07-01Not applicableUs
Naproxentablet500 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Naproxentablet250 mg/1oralContract Pharmacy Services Pa2010-03-19Not applicableUs
Naproxentablet500 mg/1oralLife Line Home Care Services, Inc.2010-02-18Not applicableUs
Naproxentablet375 mg/1oralClinical Solutions Wholesale, Llc1993-12-22Not applicableUs
Naproxentablet500 mg/1oralKAISER FOUNDATION HOSPITALS2008-10-20Not applicableUs
Naproxentablet500 mg/1oralBlenheim Pharmacal, Inc.2010-03-17Not applicableUs
Naproxentablet, delayed release500 mg/1oralRebel Distributors Corp2010-06-02Not applicableUs
Naproxentablet, delayed release375 mg/1oralTeva Pharmaceuticals USA Inc1998-07-31Not applicableUs
Naproxentablet500 mg/1oralBlenheim Pharmacal, Inc.2012-02-15Not applicableUs
Naproxentablet, delayed release500 mg/1oralSTAT Rx USA LLC2010-09-23Not applicableUs
Naproxentablet375 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-04Not applicableUs
Naproxentablet250 mg/1oralPolygen Pharmaceuticals LLC2012-02-01Not applicableUs
Naproxentablet500 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Naproxentablet, delayed release500 mg/1oralCarilion Materials Management1998-07-29Not applicableUs
Naproxentablet375 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Naproxentablet250 mg/1oralA S Medication Solutions2012-01-23Not applicableUs
Naproxentablet250 mg/1oralMajor Pharmaceuticals2008-11-08Not applicableUs
Naproxentablet500 mg/1oralAidarex Pharmaceuticals LLC2010-02-18Not applicableUs
Naproxentablet375 mg/1oralAv Pak2015-02-05Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2013-05-15Not applicableUs
Naproxentablet250 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
Naproxentablet375 mg/1oralClinical Solutions Wholesale2010-02-18Not applicableUs
Naproxentablet375 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Naproxentablet375 mg/1oralDispensing Solutions, Inc.2010-02-18Not applicableUs
Naproxentablet375 mg/1oralKeltman Pharmaceuticals Inc.2010-10-04Not applicableUs
Naproxentablet500 mg/500mgoralAlivio Medical Products, Llc2015-10-01Not applicableUs
Naproxentablet250 mg/1oralClinical Solutions Wholesale, Llc1993-12-22Not applicableUs
Naproxentablet, film coated275 mg/1oralWest ward Pharmaceutical Corp1998-02-18Not applicableUs
Naproxentablet375 mg/1oralBlenheim Pharmacal, Inc.2009-12-14Not applicableUs
Naproxentablet500 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2007-07-01Not applicableUs
Naproxentablet250 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Naproxentablet500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-09-28Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2014-05-01Not applicableUs
Naproxentablet500 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Naproxentablet375 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2015-03-07Not applicableUs
Naproxentablet500 mg/1oralbryant ranch prepack2010-02-18Not applicableUs
Naproxensuspension125 mg/5mLoralPalmetto Pharmaceuticals2013-06-25Not applicableUs
Naproxentablet375 mg/1oralPreferred Pharmaceuticals Inc.2015-08-14Not applicableUs
Naproxentablet375 mg/1oralA S Medication Solutions2007-07-01Not applicableUs
Naproxentablet500 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-02-18Not applicableUs
Naproxentablet500 mg/1oralBlenheim Pharmacal, Inc.2011-05-04Not applicableUs
Naproxentablet500 mg/1oralSTAT Rx USA LLC2011-07-18Not applicableUs
Naproxentablet250 mg/1oralAv Pak2015-02-05Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2013-05-15Not applicableUs
Naproxentablet, delayed release500 mg/1oralH.J. Harkins Company, Inc.2010-09-23Not applicableUs
Naproxentablet250 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Naproxentablet500 mg/1oralDispensing Solutions, Inc.2012-02-01Not applicableUs
Naproxentablet250 mg/1oralKeltman Pharmaceuticals Inc.2009-04-27Not applicableUs
Naproxentablet500 mg/1oralSolubiomix2015-08-262016-04-05Us
Naproxentablet375 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Naproxentablet250 mg/1oralMajor Pharmaceuticals2009-08-10Not applicableUs
Naproxentablet, film coated550 mg/1oralWest ward Pharmaceutical Corp1996-05-14Not applicableUs
Naproxentablet500 mg/1oralRebel Distributors Corp.2010-02-18Not applicableUs
Naproxentablet375 mg/1oralAidarex Pharmaceuticals LLC2010-02-18Not applicableUs
Naproxentablet500 mg/1oralAv Kare, Inc.2013-09-26Not applicableUs
Naproxentablet500 mg/1oralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
Naproxentablet500 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2010-02-18Not applicableUs
Naproxentablet500 mg/1oralPd Rx Pharmaceuticals, Inc.2010-02-18Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2011-08-30Not applicableUs
Naproxentablet500 mg/1oralNorthwind Pharmaceuticals2014-05-28Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2014-03-03Not applicableUs
Naproxentablet375 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Naproxentablet500 mg/1oralCardinal Health2010-12-132016-01-09Us
Naproxentablet250 mg/1oralREMEDYREPACK INC.2014-12-01Not applicableUs
Naproxentablet375 mg/1oralbryant ranch prepack2004-01-14Not applicableUs
Naproxentablet500 mg/1oralAmerican Health Packaging2013-09-30Not applicableUs
Naproxentablet500 mg/1oralPreferred Pharmaceuticals, Inc.2007-07-01Not applicableUs
Naproxentablet500 mg/1oralSt. Mary's Medical Park Pharmacy1999-01-01Not applicableUs
Naproxentablet500 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-07-18Not applicableUs
Naproxentablet375 mg/1oralBlenheim Pharmacal, Inc.2010-09-24Not applicableUs
Naproxentablet375 mg/1oralSTAT Rx USA LLC2010-02-18Not applicableUs
Naproxentablet500 mg/1oralMajor Pharmaceuticals2004-04-01Not applicableUs
Naproxentablet500 mg/1oralWest ward Pharmaceutical Corp2004-01-14Not applicableUs
Naproxentablet375 mg/1oralRebel Distributors Corp.2010-02-18Not applicableUs
Naproxentablet500 mg/1oralCamber Pharmaceuticals2012-01-23Not applicableUs
Naproxentablet500 mg/1oralPharmaceutica North America, Inc.2013-08-07Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2013-06-042016-04-05Us
Naproxentablet, delayed release500 mg/1oralPhysicians Total Care, Inc.2002-01-11Not applicableUs
Naproxentablet500 mg/1oralDIRECT RX2015-01-01Not applicableUs
Naproxentablet500 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2010-02-18Not applicableUs
Naproxentablet500 mg/1oralAurobindo Pharma Limited2011-11-08Not applicableUs
Naproxentablet500 mg/1oralKeltman Pharmaceuticals Inc.2009-04-27Not applicableUs
Naproxentablet500 mg/1oralBiomes Pharmaceuticals2015-03-23Not applicableUs
Naproxentablet250 mg/1oralREMEDYREPACK INC.2011-05-13Not applicableUs
Naproxentablet500 mg/1oralREMEDYREPACK INC.2013-12-05Not applicableUs
Naproxentablet250 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Naproxentablet500 mg/1oralCardinal Health2013-09-30Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2014-11-26Not applicableUs
Naproxentablet500 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
Naproxentablet250 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-02-18Not applicableUs
Naproxentablet500 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-12-13Not applicableUs
Naproxentablet500 mg/1oralTeva Pharmaceuticals USA Inc1993-12-22Not applicableUs
Naproxentablet500 mg/1oralBlenheim Pharmacal, Inc.2010-09-15Not applicableUs
Naproxentablet500 mg/1oralApotheca Inc.2007-07-01Not applicableUs
Naproxentablet375 mg/1oralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
Naproxentablet375 mg/1oralPd Rx Pharmaceuticals, Inc.2010-04-22Not applicableUs
Naproxentablet375 mg/1oralMajor Pharmaceuticals2004-04-01Not applicableUs
Naproxentablet375 mg/1oralWest ward Pharmaceutical Corp2004-01-14Not applicableUs
Naproxentablet250 mg/1oralRebel Distributors Corp.2010-02-18Not applicableUs
Naproxentablet375 mg/1oralCamber Pharmaceuticals2012-01-23Not applicableUs
Naproxentablet500 mg/1oralAphena Pharma Solutions Tennessee, Llc2004-04-01Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2012-12-28Not applicableUs
Naproxentablet375 mg/1oralH.J. Harkins Company, Inc.2007-07-01Not applicableUs
Naproxentablet250 mg/1oralPd Rx Pharmaceuticals, Inc.2004-01-14Not applicableUs
Naproxentablet, delayed release500 mg/1oralbryant ranch prepack2010-06-02Not applicableUs
Naproxentablet375 mg/1oralAurobindo Pharma Limited2011-11-08Not applicableUs
Naproxentablet375 mg/1oralBiomes Pharmaceuticals2015-03-23Not applicableUs
Naproxentablet500 mg/1oralLiberty Pharmaceuticals, Inc.2010-02-18Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2013-01-10Not applicableUs
Naproxentablet375 mg/1oralUnit Dose Services2007-07-01Not applicableUs
Naproxentablet250 mg/1oralCardinal Health2010-02-18Not applicableUs
Naproxentablet500 mg/1oralProficient Rx LP2010-02-18Not applicableUs
Naproxentablet500 mg/1oralContract Pharmacy Services Pa2010-03-19Not applicableUs
Naproxentablet250 mg/1oralGlenmark Pharmaceuticals Inc., Usa2007-07-01Not applicableUs
Naproxentablet375 mg/1oralMajor Pharmaceuticals2011-02-28Not applicableUs
Naproxentablet250 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-07-18Not applicableUs
Naproxentablet375 mg/1oralTeva Pharmaceuticals USA Inc1993-12-22Not applicableUs
Naproxentablet500 mg/1oralBlenheim Pharmacal, Inc.2010-08-19Not applicableUs
Naproxentablet500 mg/1oralBlenheim Pharmacal, Inc.2015-07-06Not applicableUs
Naproxentablet250 mg/1oralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
Naproxentablet250 mg/1oralAidarex Pharmaceuticals LLC2010-02-18Not applicableUs
Naproxentablet250 mg/1oralPd Rx Pharmaceuticals, Inc.2004-01-14Not applicableUs
Naproxentablet250 mg/1oralREMEDYREPACK INC.2013-08-27Not applicableUs
Naproxentablet375 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Naproxentablet250 mg/1oralCardinal Health2009-08-10Not applicableUs
Naproxentablet500 mg/1oralGolden State Medical Supply, Inc.2010-02-18Not applicableUs
Naproxentablet375 mg/1oralProficient Rx LP2007-07-01Not applicableUs
Naproxentablet375 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-18Not applicableUs
Naproxentablet500 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-02-18Not applicableUs
Naproxentablet500 mg/1oralGlenmark Pharmaceuticals Inc., Usa2007-07-01Not applicableUs
Naproxensuspension125 mg/5mLoralPalmetto Pharmaceuticals2013-06-25Not applicableUs
Naproxentablet250 mg/1oralWest ward Pharmaceutical Corp2004-01-14Not applicableUs
Naproxentablet500 mg/1oralBlenheim Pharmacal, Inc.2013-03-28Not applicableUs
Naproxentablet250 mg/1oralCamber Pharmaceuticals2012-01-23Not applicableUs
Naproxentablet375 mg/1oralRebel Distributors Corp2007-07-01Not applicableUs
Naproxentablet250 mg/1oralAphena Pharma Solutions Tennessee, Llc2009-08-10Not applicableUs
Naproxentablet, delayed release500 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-02-03Not applicableUs
Naproxentablet375 mg/1oralREMEDYREPACK INC.2013-07-25Not applicableUs
Naproxentablet500 mg/1oralPolygen Pharmaceuticals LLC2012-02-01Not applicableUs
Naproxentablet500 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Naproxentablet500 mg/1oralDIRECT RX2014-01-01Not applicableUs
Naproxentablet250 mg/1oralAurobindo Pharma Limited2011-11-08Not applicableUs
Naproxentablet375 mg/1oralCarilion Materials Management2007-07-01Not applicableUs
Naproxentablet250 mg/1oralBiomes Pharmaceuticals2015-03-23Not applicableUs
Naproxentablet500 mg/1oralMajor Pharmaceuticals2009-11-20Not applicableUs
Naproxen Delayed Releasetablet500 mg/1oralCamber Pharmaceuticals2012-01-23Not applicableUs
Naproxen Delayed Releasetablet500 mg/1oralAv Kare, Inc.2013-10-24Not applicableUs
Naproxen Delayed Releasetablet375 mg/1oralCamber Pharmaceuticals2012-01-23Not applicableUs
Naproxen Delayed Releasetablet, delayed release500 mg/1oralNorthwind Pharmaceuticals2014-05-16Not applicableUs
Naproxen Delayed Releasetablet375 mg/1oralAv Kare, Inc.2013-10-24Not applicableUs
Naproxen Delayed Releasetablet500 mg/1oralBlenheim Pharmacal, Inc.2015-06-04Not applicableUs
Naproxen Delayed Releasetablet500 mg/1oralA S Medication Solutions2012-01-23Not applicableUs
Naproxen KitkitPharmaceutica North America, Inc2013-08-28Not applicableUs
Naproxen Sodiumtablet550 mg/1oralProficient Rx LP2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Naproxen Sodiumtablet550 mg/1oralGlenmark Pharmaceuticals Inc., Usa2007-08-01Not applicableUs
Naproxen Sodiumtablet550 mg/1oralAidarex Pharmaceuticals LLC2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralAmneal Pharmaceuticals of New York, LLC2007-04-26Not applicableUs
Naproxen Sodiumtablet275 mg/1oralHikma Pharmaceutical1998-02-18Not applicableUs
Naproxen Sodiumtablet275 mg/1oralBlenheim Pharmacal, Inc.2012-01-12Not applicableUs
Naproxen Sodiumtablet550 mg/1oralSTAT Rx USA LLC1998-02-18Not applicableUs
Naproxen Sodiumtablet250 mg/1oralNorthwind Pharmaceuticals, LLC2014-08-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Naproxen Sodiumtablet, film coated550 mg/1oralAurobindo Pharma Limited2011-10-31Not applicableUs
Naproxen Sodiumtablet550 mg/1oralA S Medication Solutions2007-04-26Not applicableUs
Naproxen Sodiumtablet275 mg/1oralGlenmark Pharmaceuticals Inc., Usa2007-08-01Not applicableUs
Naproxen Sodiumtablet550 mg/1oralMajor Pharmaceuticals2007-04-26Not applicableUs
Naproxen Sodiumtablet, film coated550 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2010-11-01Not applicableUs
Naproxen Sodiumtablet, film coated275 mg/1oralPd Rx Pharmaceuticals, Inc.1993-12-22Not applicableUs
Naproxen Sodiumtablet, film coated550 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Naproxen Sodiumtablet, film coated275 mg/1oralAurobindo Pharma Limited2011-10-31Not applicableUs
Naproxen Sodiumtablet275 mg/1oralMedsource Pharmaceuticals2007-08-01Not applicableUs
Naproxen Sodiumtablet, film coated, extended release500 mg/1oralActavis Pharma, Inc.2014-09-30Not applicableUs
Naproxen Sodiumtablet275 mg/1oralMajor Pharmaceuticals2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralRebel Distributors Corp2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralNorthwind Pharmaceuticals, LLC2014-08-07Not applicableUs
Naproxen Sodiumtablet550 mg/1oralAmneal Pharmaceuticals of New York, LLC2007-04-26Not applicableUs
Naproxen Sodiumtablet, film coated550 mg/1oralTeva Pharmaceuticals USA Inc1993-12-22Not applicableUs
Naproxen Sodiumtablet275 mg/1oralPd Rx Pharmaceuticals, Inc.2007-08-01Not applicableUs
Naproxen Sodiumtablet, film coated, extended release375 mg/1oralActavis Pharma, Inc.2014-09-30Not applicableUs
Naproxen Sodiumtablet550 mg/1oralBlenheim Pharmacal, Inc.2010-03-17Not applicableUs
Naproxen Sodiumtablet275 mg/1oralAmneal Pharmaceuticals of New York, LLC2007-04-26Not applicableUs
Naproxen Sodiumtablet, film coated275 mg/1oralTeva Pharmaceuticals USA Inc1993-12-22Not applicableUs
Naproxen Sodiumtablet275 mg/1oralBlenheim Pharmacal, Inc.2010-03-22Not applicableUs
Naproxen Sodiumtablet550 mg/1oralAv Kare, Inc.2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralAv Pak2012-10-11Not applicableUs
Naproxen Sodiumtablet550 mg/1oralH.J. Harkins Company, Inc.2007-07-01Not applicableUs
Naproxen Sodiumtablet220 mg/1oralNorthwind Pharmaceuticals, LLC2014-07-14Not applicableUs
Naproxen Sodiumtablet550 mg/1oralbryant ranch prepack2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralPreferred Pharmaceuticals, Inc.2007-04-26Not applicableUs
Naproxen Sodiumtablet220 mg/1oralDIRECT RX2016-03-07Not applicableUs
Naproxen Sodiumtablet550 mg/1oralRx Change Co.2014-11-11Not applicableUs
Naproxen Sodiumtablet275 mg/1oralBlenheim Pharmacal, Inc.2013-08-26Not applicableUs
Naproxen Sodiumtablet275 mg/1oralAv Kare, Inc.2007-04-26Not applicableUs
Naproxen Sodiumtablet275 mg/1oralAv Pak2012-10-11Not applicableUs
Naproxen Sodiumtablet550 mg/1oralPhysicians Total Care, Inc.1994-01-14Not applicableUs
Naproxen Sodiumcapsule550 mg/1oralDIRECT RX2014-01-01Not applicableUs
Naproxen Sodiumtablet550 mg/1oralKeltman Pharmaceuticals Inc.2010-12-10Not applicableUs
Naproxen Sodiumtablet275 mg/1oralAidarex Pharmaceuticals LLC2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralSTAT Rx USA LLC2007-08-01Not applicableUs
Naproxen Sodiumtablet550 mg/1oralREMEDYREPACK INC.2011-06-09Not applicableUs
Naproxen Sodiumtablet550 mg/1oralREMEDYREPACK INC.2013-08-23Not applicableUs
Naproxen Sodiumtablet275 mg/1oralAmneal Pharmaceuticals of New York, LLC2007-04-26Not applicableUs
Naproxen Sodiumtablet, film coated550 mg/1oralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Naproxen Sodiumtablet275 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Naproxen Sodiumtablet550 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralREMEDYREPACK INC.2011-11-03Not applicableUs
Naproxen Sodiumtablet550 mg/1oralUnit Dose Services2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralAtlantic Biologicals Corps2007-04-26Not applicableUs
Naproxen Sodiumtablet550 mg/1oralPd Rx Pharmaceuticals, Inc.2007-04-26Not applicableUs
Naproxen Sodiumtablet275 mg/1oralbryant ranch prepack2007-08-01Not applicableUs
Naproxen Tabletstablet500 mg/1oralDr. Reddy's Laboratories Limited2004-06-05Not applicableUs
Naproxen Tabletstablet375 mg/1oralDr. Reddy's Laboratories Limited2004-06-05Not applicableUs
Naproxen Tabletstablet250 mg/1oralDr. Reddy's Laboratories Limited2004-06-05Not applicableUs
Sallus Pain Relief Collection With NaproxenkitSallus Laboratories, Llc2007-07-01Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Naproxen Sodiumtablet220 mg/1oral7 Eleven2014-08-11Not applicableUs
7 Select Naproxen Sodiumtablet, film coated220 mg/1oral7 Eleven2014-08-05Not applicableUs
Alevecapsule, liquid filled220 mg/1oralBayer Health Care Llc, Consumer Care2007-02-20Not applicableUs
Alevetablet220 mg/1oralLil' Drug Store Products, Inc2000-01-01Not applicableUs
Alevetablet220 mg/1oralR J General Corporation2014-02-26Not applicableUs
Alevetablet220 mg/1oralCardinal Health1994-01-11Not applicableUs
Alevetablet220 mgoralBayer Inc Consumer Care2009-06-15Not applicableCanada
Alevetablet220 mg/1oralBayer Health Care Consumer Care2002-07-26Not applicableUs
Aleve Back and Body Paincapsule220 mgoralBayer Inc Consumer Care2015-06-30Not applicableCanada
Aleve Capletstablet220 mg/1oralJc World Bell Wholesale Co., Inc.2014-07-14Not applicableUs
Aleve Capletstablet220 mg/1oralBayer Health Care Llc, Consumer Care2014-02-26Not applicableUs
Aleve Capletstablet220 mg/1oralYour Safety Company2016-03-15Not applicableUs
Aleve Caplets - Easy Open Arthritis Captablet220 mg/1oralBayer Health Care Consumer Care2013-11-11Not applicableUs
Aleve Easy Open Arthritis Capcapsule, liquid filled220 mg/1oralBayer Health Care Llc, Consumer Care2007-02-28Not applicableUs
Aleve Easy Open Arthritis Captablet220 mg/1oralBayer Health Care Consumer Care2002-07-26Not applicableUs
Aleve Gelcapstablet, coated220 mg/1oralBayer Health Care Consumer Care2002-08-01Not applicableUs
Aleve Gelcapstablet, coated220 mg/1oralBayer Health Care Consumer Care2002-08-01Not applicableUs
Aleve Liquid Gelscapsule220 mgoralBayer Inc Consumer Care2011-09-12Not applicableCanada
All Day Pain Relieftablet220 mg/1oralTOP CARE (Topco Associates LLC)2014-06-30Not applicableUs
All Day Pain Relieftablet220 mg/1oralCardinal Health (Leader) 497812015-11-30Not applicableUs
All Day Pain Relieftablet, film coated220 mg/1oralH E B1997-02-24Not applicableUs
All Day Pain Relieftablet220 mg/1oralRebel Distributors Corp1997-01-14Not applicableUs
All Day Pain Relieftablet220 mg/1oralCVS Pharmacy1997-01-23Not applicableUs
All Day Pain Reliefcapsule, liquid filled220 mg/1oralHarmon Stores2015-07-31Not applicableUs
All Day Pain Relieftablet220 mg/1oralCardinal Health (Leader)2012-08-30Not applicableUs
All Day Pain Relieftablet220 mg/1oralCardinal Health (Leader) 497812012-06-25Not applicableUs
All Day Pain Relieftablet, film coated200 mg/1oralH E B2008-02-12Not applicableUs
All Day Pain Relieftablet220 mg/1oralCardinal Health (Leader) 497812015-11-30Not applicableUs
All Day Pain Relieftablet220 mg/1oralCVS Pharmacy2014-04-30Not applicableUs
All Day Pain Relieftablet, film coated220 mg/1oralWalgreen Company1997-01-14Not applicableUs
All Day Pain Relieftablet220 mg/1oralSuper Valu (Equaline)2010-11-15Not applicableUs
All Day Pain Relieftablet220 mg/1oralH E B1997-02-24Not applicableUs
All Day Pain Relieftablet, film coated220 mg/1oralCVS Pharmacy2005-09-26Not applicableUs
All Day Pain Relieftablet220 mg/1oralEqualine (Super Valu)2013-05-09Not applicableUs
All Day Pain Relieftablet220 mg/1oralFreds Inc2014-08-31Not applicableUs
All Day Pain Relieftablet220 mg/1oralP And L Development Of New York Corporation (Ready In Case)2014-03-28Not applicableUs
All Day Pain Relieftablet220 mg/1oralWalgreens2014-03-31Not applicableUs
All Day Pain Relieftablet220 mg/1oralHannaford Brothers Company1997-04-09Not applicableUs
All Day Pain Relieftablet220 mg/1oralCardinal Health (Leader) 497812014-07-31Not applicableUs
All Day Pain Relieftablet220 mg/1oralFreds Inc2014-03-28Not applicableUs
All Day Pain Relieftablet220 mg/1oralP And L Development Of New York Corporation (Ready In Case)2014-02-28Not applicableUs
All Day Pain Relieftablet220 mg/1oralWalgreens2014-03-31Not applicableUs
All Day Pain Relieftablet200 mg/1oralWalgreen Company2014-07-31Not applicableUs
All Day Pain Relieftablet220 mg/1oralH E B2015-09-30Not applicableUs
All Day Pain Relieftablet, film coated220 mg/1oralHannaford Brothers Company1997-04-09Not applicableUs
All Day Pain Relieftablet220 mg/1oralFreds Inc2015-09-30Not applicableUs
All Day Pain Relieftablet220 mg/1oralP And L Development Of New York Corporation (Ready In Case)2014-06-30Not applicableUs
All Day Pain Relieftablet220 mg/1oralWe Care Distributor Inc.2011-09-30Not applicableUs
All Day Pain Relieftablet220 mg/1oralThe Kroger Co.2011-02-02Not applicableUs
All Day Pain Relieftablet, film coated220 mg/1oralCVS Pharmacy1997-01-23Not applicableUs
All Day Pain Relieftablet220 mg/1oralCardinal Health (Leader) 497812012-06-25Not applicableUs
All Day Pain Relieftablet220 mg/1oralFreds Inc2015-09-30Not applicableUs
All Day Pain Relief Naproxen Sodiumtablet220 mg/1oralAmerican Health Packaging2015-06-05Not applicableUs
All Day Pain Relief Naproxen Sodiumtablet220 mg/1oralCamber Consumer Care2015-05-26Not applicableUs
All Day Relieftablet, film coated220 mg/1oralMajor Pharmaceuticals1997-01-09Not applicableUs
All Day Relieftablet, film coated220 mg/1oralMedicine Shoppe International Inc2001-09-03Not applicableUs
All Day Relieftablet220 mg/1oralClinical Solutions Wholesale1997-01-09Not applicableUs
All Day Relieftablet220 mg/1oralMeijer Distribution Inc1997-05-29Not applicableUs
All Day Relieftablet220 mg/1oralH.J. Harkins Company, Inc.1997-01-09Not applicableUs
All Day Relieftablet220 mg/1oralWestern Family Foods Inc1997-01-15Not applicableUs
All Day Relieftablet220 mg/1oralHy Vee Inc1997-04-01Not applicableUs
All Day Relieftablet, film coated220 mg/1oralWestern Family Foods Inc1997-01-14Not applicableUs
All Day Relieftablet220 mg/1oralRugby Laboratories2014-03-10Not applicableUs
All Day Relieftablet220 mg/1oralKroger Company2004-05-10Not applicableUs
All Day Relieftablet, film coated220 mg/1oralMeijer Distribution Inc1997-01-23Not applicableUs
All Day Relieftablet, film coated220 mg/1oralHy Vee Inc1997-04-01Not applicableUs
All Day Relieftablet220 mg/1oralPublix Super Markets Inc1997-12-29Not applicableUs
All Day Relieftablet220 mg/1oralPreferred Pharmaceuticals Inc.2015-05-06Not applicableUs
All Day Relieftablet220 mg/1oralRugby Laboratories2014-03-10Not applicableUs
All Day Relieftablet220 mg/1oralLake Erie Medical DBA Quality Care Products LLC2014-03-102016-01-21Us
All Day Relieftablet, film coated220 mg/1oralWestern Family Foods Inc2007-12-19Not applicableUs
All Day Relieftablet, film coated220 mg/1oralPublix Super Markets Inc1997-12-29Not applicableUs
All Day Relieftablet, film coated220 mg/1oralKroger Company1997-01-16Not applicableUs
All Day Relieftablet220 mg/1oralMajor Pharmaceuticals1997-01-09Not applicableUs
All Day Relieftablet220 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1997-01-09Not applicableUs
All Day Relieftablet, film coated220 mg/1oralMeijer Distribution Inc2004-05-28Not applicableUs
All Day Relieftablet, film coated220 mg/1oralHy Vee Inc2008-09-02Not applicableUs
All Day Relieftablet, film coated220 mg/1oralKroger Company2005-02-08Not applicableUs
Bayer Alevetablet220 mg/1oralUnifirst First Aid Corporation2014-01-24Not applicableUs
Being Well All Day Pain Relieftablet, film coated220 mg/1oralSave A Lot Food Stores Ltd2006-02-25Not applicableUs
Berkley and Jensen Naproxen Sodiumtablet, film coated220 mg/1oralBJWC2007-09-17Not applicableUs
Calmadol Pain Relievertablet220 mg/1oralGrandall Distributing Co., Inc.2015-03-31Not applicableUs
Care One All Day Pain Relieftablet220 mg/1oralAmerican Sales Company2004-05-04Not applicableUs
Care One All Day Pain Relieftablet, film coated220 mg/1oralAmerican Sales Company2004-04-05Not applicableUs
Care One All Day Pain Relieftablet, film coated220 mg/1oralAmerican Sales Company2008-09-26Not applicableUs
Careall Naproxencapsule220 mg/1oralNew World Imports, Inc.2013-05-01Not applicableUs
Careone Naproxen Sodiumcapsule, liquid filled220 mg/1oralAmerican Sales Company2011-12-08Not applicableUs
Dg Health All Day Pain Relieftablet, film coated220 mg/1oralDolgencorp Inc2010-01-17Not applicableUs
Dg Health Naproxen Sodiumcapsule, liquid filled220 mg/1oralDolgencorp, LLC2011-06-01Not applicableUs
Dg Health Naproxen Sodiumtablet, film coated220 mg/1oralDolgencorp, LLC2013-11-21Not applicableUs
Equaline All Day Pain Relieftablet, film coated220 mg/1oralSupervalu Inc2005-02-08Not applicableUs
Equaline All Day Pain Relieftablet220 mg/1oralSupervalu Inc2004-08-10Not applicableUs
Equaline All Day Pain Relieftablet, film coated220 mg/1oralSupervalu Inc2004-08-10Not applicableUs
Equaline Naproxen Sodiumcapsule, liquid filled220 mg/1oralSupervalu Inc2010-11-23Not applicableUs
Equaline Naproxen Sodiumtablet220 mg/1oralSupervalu Inc2014-09-24Not applicableUs
Equaline Naproxen Sodiumtablet, film coated220 mg/1oralSupervalu Inc2014-09-24Not applicableUs
Equaline Naproxen Sodiumtablet, film coated220 mg/1oralSupervalu Inc2014-07-14Not applicableUs
Equate Naproxen Sodiumtablet200 mg/1oralWal Mart Stores Inc2013-09-11Not applicableUs
Equate Naproxen Sodiumtablet220 mg/1oralWal Mart Stores Inc2007-05-02Not applicableUs
Equate Naproxen Sodiumtablet, film coated220 mg/1oralWal Mart Stores Inc2007-04-27Not applicableUs
Equate Naproxen Sodiumtablet, film coated200 mg/1oralWal Mart Stores Inc2013-08-09Not applicableUs
Equate Naproxen Sodiumcapsule, liquid filled220 mg/1oralWal Mart Stores Inc2013-08-09Not applicableUs
Equate Naproxen Sodiumcapsule, liquid filled220 mg/1oralWal Mart Stores Inc2011-07-26Not applicableUs
Exchange Select Naproxen Sodiumtablet, film coated220 mg/1oralArmy & Air Force Exchange Service2008-08-26Not applicableUs
Family Wellness Naproxen Sodiumtablet, film coated220 mg/1oralFamily Dollar Services Inc1997-01-14Not applicableUs
Flanax Pain Relievertablet220 mg/1oralBelmora LLC2012-12-06Not applicableUs
Formucare Naproxen Sodium Pain Reliever Fever Reducertablet, film coated220 mg/1oralAccess Business Group International LLC2009-09-29Not applicableUs
Fulton Street Market Naproxen Sodiumtablet, film coated220 mg/1oralAccess Business Group LLC2000-07-06Not applicableUs
Good Neighbor Pharmacy Naproxen Sodiumtablet, film coated220 mg/1oralAmerisource Bergen2015-08-03Not applicableUs
Good Neighbor Pharmacy Naproxen Sodiumtablet220 mg/1oralAmerisource Bergen1998-03-12Not applicableUs
Good Neighbor Pharmacy Naproxen Sodiumcapsule, liquid filled220 mg/1oralAmerisource Bergen2011-01-06Not applicableUs
Good Neighbor Pharmacy Pain Relief All Daytablet, film coated220 mg/1oralAmerisource Bergen1997-01-15Not applicableUs
Good Sense All Day Pain Relieftablet, film coated200 mg/1oralL. Perrigo Company1997-01-14Not applicableUs
Good Sense All Day Pain Relieftablet220 mg/1oralL Perrigo Company1997-01-14Not applicableUs
Good Sense All Day Pain Relieftablet220 mg/1oralProficient Rx LP1997-01-14Not applicableUs
Good Sense All Day Pain Relieftablet220 mg/1oralDispensing Solutions, Inc.1997-01-14Not applicableUs
Good Sense All Day Pain Relieftablet220 mg/1oralAidarex Pharmaceuticals LLC1997-01-14Not applicableUs
Good Sense All Day Pain Relieftablet220 mg/1oralUnit Dose Services1997-01-14Not applicableUs
Good Sense Naproxen Sodiumtablet, film coated220 mg/1oralL. Perrigo Company2014-03-31Not applicableUs
Good Sense Naproxen Sodiumtablet220 mg/1oralL. Perrigo Company2014-04-23Not applicableUs
Good Sense Naproxen Sodiumcapsule, liquid filled220 mg/1oralL. Perrigo Company2010-12-02Not applicableUs
Health Mart Naproxen Sodiumtablet, film coated220 mg/1oralMc Kesson2011-11-21Not applicableUs
Health Mart Naproxen Sodiumcapsule, liquid filled220 mg/1oralMc Kesson2011-11-21Not applicableUs
Healthy Accents All Day Pain Relieftablet220 mg/1oralDZA Brands LLC2011-07-19Not applicableUs
Healthy Accents All Day Pain Relieftablet, film coated220 mg/1oralDZA Brands LLC2008-01-22Not applicableUs
Healthy Accents Naproxen Sodiumtablet, film coated220 mg/1oralDZA Brands LLC2013-05-22Not applicableUs
Healthy Accents Naproxen Sodiumcapsule, liquid filled220 mg/1oralDZA Brands LLC2012-04-05Not applicableUs
Healthy Accents Naproxen Sodiumtablet220 mg/1oralDZA Brands LLC2011-07-19Not applicableUs
Healthy Accents Naproxen Sodiumtablet, film coated220 mg/1oralDZA Brands LLC2008-01-22Not applicableUs
Kirkland Signature Naproxen Sodiumtablet, film coated220 mg/1oralCostco Wholesale Company2007-06-04Not applicableUs
Leader All Daytablet220 mg/1oralCardinal Health2015-04-29Not applicableUs
Leader All Day Pain Relieftablet, film coated220 mg/1oralCardinal Health (Leader) 372052012-06-25Not applicableUs
Leader All Day Pain Relieftablet, film coated220 mg/1oralCardinal Health2015-03-12Not applicableUs
Leader All Day Pain Relieftablet, film coated220 mg/1oralCardinal Health (Leader) 372052001-09-26Not applicableUs
Leader Naproxen Sodiumcapsule, liquid filled220 mg/1oralCardinal Health2010-12-01Not applicableUs
Lil Drug Store Pain Relief All Daytablet220 mg/1oralLil' Drug Store Products, Inc.2011-01-27Not applicableUs
Maxidol Liquid Gelscapsule220 mgoralBayer Inc Consumer Care2012-05-17Not applicableCanada
Medique Mediproxentablet, film coated220 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Members Mark Naproxen Sodiumtablet, film coated220 mg/1oralSam's West Inc2007-05-29Not applicableUs
Menstridoltablet220 mg/1oralBayer Health Care Llc, Consumer Care2014-07-01Not applicableUs
Midol Extended Relieftablet220 mg/1oralBayer Health Care Llc, Consumer Care2009-10-20Not applicableUs
Modern Pain Medicinetablet220 mg/1oralAthlete's Needs Inc2013-05-06Not applicableUs
Motrimax 12 Hour Back & Bodycapsule200 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Motrimax 12 Hour Tabletstablet220 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Naproxentablet220 mgoralPharmascience Inc2011-03-18Not applicableCanada
Naproxentablet220 mgoralPharmel IncNot applicableNot applicableCanada
Naproxentablet220 mg/1oralPharmadel LLC2013-03-25Not applicableUs
Naproxentablet220 mg/1oralChain Drug Consortium2014-10-27Not applicableUs
Naproxentablet220 mg/1oralZee Medical Inc2015-03-31Not applicableUs
Naproxencapsule220 mg/1oralChain Drug Consortium2014-10-27Not applicableUs
Naproxentablet220 mg/1oralMedline Industries, Inc.2002-07-26Not applicableUs
Naproxentablet220 mgoralPerrigo International2013-09-16Not applicableCanada
Naproxen All Day Relief for Paintablet220 mg/1oralAllegiant Health2014-12-23Not applicableUs
Naproxen Caplets All Day Relief for Paintablet220 mg/1oralAllegiant Health2014-12-23Not applicableUs
Naproxen Liquid Gelscapsule220 mgoralPharmascience IncNot applicableNot applicableCanada
Naproxen Menstrual Pain Relieftablet220 mgoralPharmascience Inc2014-01-24Not applicableCanada
Naproxen Pain Relieftablet220 mg/1oralRebel Distributors Corp1998-03-12Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralKroger Company2014-03-15Not applicableUs
Naproxen Sodiumtablet220 mg/1oralRugby Laboratories Inc2009-11-25Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralTIME CAP LABORATORIES, INC2015-12-07Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralDr.Reddy's Laboratories Limited1998-07-29Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralHealthy Accents (DZA Brands, LLC)2014-09-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralCVS Pharmacy2014-11-30Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralChain Drug Marketing Association2009-09-03Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralAurohealth LLC2016-03-18Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralSafeway, Inc.2015-02-28Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralWalgreen Company2014-08-04Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralThe Kroger Co.2014-10-31Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralMEIJER, INC.2014-09-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralEQUATE (Walmart Stores, Inc.)2014-09-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralAafes/Your Military Exchanges2015-11-30Not applicableUs
Naproxen Sodiumtablet, film coated, extended release220 mg/1oralSPIRIT PHARMACEUTICALS,LLC2011-08-01Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralCVS Pharmacy2015-07-22Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralKroger Company2010-11-23Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralEqualine (Super Valu)2014-09-30Not applicableUs
Naproxen Sodiumtablet220 mg/1oralMeijer Distribution Inc2014-03-05Not applicableUs
Naproxen Sodiumtablet220 mg/1oralPerrigo New York Inc2014-04-11Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralWestern Family Foods Inc2011-01-18Not applicableUs
Naproxen Sodiumtablet220 mg/1oralFamily Dollar (FAMILY WELLNESS)2014-04-30Not applicableUs
Naproxen Sodiumtablet200 1/1oralAdvanced First Aid, Inc.2015-04-09Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralTOP CARE (Topco Associates LLC)2014-09-30Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralDr.Reddy's Laboratories Limited1998-07-29Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralHealthy Accents (DZA Brands, LLC)2013-12-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralQUALITY CHOICE (Chain Drug Marketing Association)2014-10-31Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralCVS Pharmacy2016-03-15Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralRite Aid Corporation2010-12-15Not applicableUs
Naproxen Sodiumtablet220 mg/1oralThe Kroger Co.2014-11-09Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralTarget Corporation2014-12-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralSafeway2010-12-13Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralKroger Company1997-01-16Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralHy Vee Inc2010-11-29Not applicableUs
Naproxen Sodiumtablet220 mg/1oralFamily Dollar (FAMILY WELLNESS)2013-11-01Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralAAA Pharmaceutical, Inc.2012-12-15Not applicableUs
Naproxen Sodiumtablet220 mg/1oralPhysicians Total Care, Inc.2005-05-23Not applicableUs
Naproxen Sodiumtablet220 mg/1oralProficient Rx LP2014-04-11Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralRite Aid Corporation2001-05-16Not applicableUs
Naproxen Sodiumtablet220 mg/1oralKroger Company2014-03-06Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralShopko Stores Operating Co., LLC2013-07-30Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralMeijer Distribution Inc2014-03-05Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralPolygen Pharmaceuticals LLC2012-11-13Not applicableUs
Naproxen Sodiumtablet220 mg/1oralFamily Dollar (FAMILY WELLNESS)2012-08-15Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralAAA Pharmaceutical, Inc.2012-12-15Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralKinray LLC2014-04-25Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralWalgreens2014-10-31Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralCare One (American Sales Company)2014-10-31Not applicableUs
Naproxen Sodiumtablet200 mg/1oralCVS Pharmacy2016-01-05Not applicableUs
Naproxen Sodiumtablet220 mg/1oralRite Aid Corporation2001-05-16Not applicableUs
Naproxen Sodiumtablet220 mg/1oralMARKSANS PHARMA LIMITED2011-05-04Not applicableUs
Naproxen Sodiumtablet220 mg/1oralTOP CARE (Topco Associates LLC)2014-06-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralH E B2015-07-31Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralShopko Stores Operating Co., LLC2014-05-19Not applicableUs
Naproxen Sodiumtablet220 mg/1oralEQUATE (Walmart Stores, Inc.)2014-04-30Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralPolygen Pharmaceuticals LLC2012-06-11Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralWestern Family Foods, Inc.2014-12-31Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralKinray LLC2014-04-25Not applicableUs
Naproxen Sodiumtablet220 mg/1oralMARKSANS PHARMA LIMITED2011-05-28Not applicableUs
Naproxen Sodiumtablet220 mg/1oralGranules India Limited2011-09-30Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralMaximino Import2008-08-20Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralMeijer Distribution Inc2004-05-28Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralHy Vee2014-09-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralSMART SENSE (Kmart)2014-12-31Not applicableUs
Naproxen Sodiumtablet220 mg/1oralKinray2009-11-25Not applicableUs
Naproxen Sodiumtablet220 mg/1oralTYA Pharmaceuticals2014-04-11Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralPreferred Pharmaceuticals, Inc.2012-03-12Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralShopko Stores Operating Co., LLC.2014-12-31Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralAmerisource Bergen (Good Neighbor Pharmacy) 461222014-11-30Not applicableUs
Naproxen Sodiumtablet220 mg/1oralCardinal Health (Leader) 497812014-07-31Not applicableUs
Naproxen Sodiumtablet220 mg/1oralGranules India Limited2011-09-30Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralWin Co Foods, Llc2014-12-15Not applicableUs
Naproxen Sodiumtablet220 mg/1oralEQUATE (Walmart Stores, Inc.)2014-02-12Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralTIME CAP LABORATORIES, INC2015-12-16Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralChain Drug Marketing Association2009-06-19Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2014-11-30Not applicableUs
Naproxen Sodiumtablet, film coated220 mg/1oralKroger Company2005-02-08Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralH E B2011-01-04Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralPublix Supermarkets, Inc.2015-06-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralCVS Pharmacy2010-11-23Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralWalgreen Company2010-11-30Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralMeijer Distribution Inc2011-01-14Not applicableUs
Naproxen Sodiumtablet220 mg/1oralMedline Industries2013-04-30Not applicableUs
Naproxen Sodiumtablet220 mg/1oralFamily Dollar (FAMILY WELLNESS)2014-04-30Not applicableUs
Naproxen Sodiumtablet, film coated, extended release220 mg/1oralJ.P. BUSINESS ENTERPRISE2013-08-20Not applicableUs
Naproxen Sodiumcapsule, liquid filled220 mg/1oralMc Kesson (Health Mart)2014-10-31Not applicableUs
Naproxen Sodiumtablet, coated220 mg/1oralWin Co Foods, Llc2014-12-15Not applicableUs
Naproxen Sodium (nsaid) Fever Reducer/ Pain Relievertablet220 mg/1oralAmneal Pharmaceuticals2009-11-25Not applicableUs
Naproxen Sodium (nsaid) Fever Reducer/ Pain Relievertablet220 mg/1oralAmneal Pharmaceuticals2009-11-25Not applicableUs
Naproxen Sodium All Day Pain Relieftablet, film coated220 mg/1oralRite Aid Corporation2001-05-16Not applicableUs
Naproxen Sodium Capletstablet220 mgoralVita Health Products IncNot applicableNot applicableCanada
Naproxen Sodium Tabletstablet220 mgoralApotex Inc2014-03-06Not applicableCanada
Naproxen Sodium Tabletstablet220 mgoralVita Health Products IncNot applicableNot applicableCanada
Nx 12 Hourtablet220 mgoralPerrigo InternationalNot applicableNot applicableCanada
Pain Relieftablet, film coated220 mg/1oralSafeway2015-03-02Not applicableUs
Pain Relieftablet, film coated220 mg/1oralWalgreen Company2011-10-22Not applicableUs
Pain Relief All Daytablet220 mg/1oralWalgreen Company1997-01-14Not applicableUs
Pain Relief All Daytablet, film coated220 mg/1oralSafeway2007-09-12Not applicableUs
Pain Relief All Daytablet, film coated220 mg/1oralSafeway2008-10-03Not applicableUs
Pain Zerotablet220 mg/1oralProvision Medical Products2015-03-31Not applicableUs
Rexall All Day Pain Relieftablet, film coated220 mg/1oralDolgencorp Inc2012-09-28Not applicableUs
Rexall All Day Pain Relieftablet, film coated220 mg/1oralDolgencorp, LLC2013-07-31Not applicableUs
Rugby All Day Relieftablet220 mg/1oralPreferred Pharmaceuticals Inc.2016-02-01Not applicableUs
Rugby All Day Relieftablet220 mg/1oralRugby Laboratories2015-09-02Not applicableUs
Rugby All Day Relieftablet, film coated220 mg/1oralRugby Laboratories2015-09-02Not applicableUs
Rx Act All Day Pain Relieftablet, film coated220 mg/1oralH E B2009-02-12Not applicableUs
Rx Act All Day Pain Relieftablet, film coated220 mg/1oralH E B2008-02-12Not applicableUs
Rx Act All Day Pain Relieftablet220 mg/1oralH E B1997-02-24Not applicableUs
Rx Act Naproxen Sodiumcapsule, liquid filled220 mg/1oralH E B2011-01-04Not applicableUs
Shoprite Naproxen Sodiumtablet, film coated220 mg/1oralWakefern Food Corporation2013-08-14Not applicableUs
Shoprite Naproxen Sodiumcapsule, liquid filled220 mg/1oralWakefern Food Corporation2013-06-20Not applicableUs
Signature Care Pain Relieftablet220 mg/1oralSafeway2015-10-24Not applicableUs
Signature Care Pain Relieftablet, film coated220 mg/1oralSafeway2015-09-29Not applicableUs
Signature Care Pain Relieftablet, film coated220 mg/1oralSafeway2015-09-04Not applicableUs
Simply Right Naproxen Sodiumtablet, film coated220 mg/1oralSam's West Inc2014-02-12Not applicableUs
Simply Right Naproxen Sodiumcapsule, liquid filled220 mg/1oralSam's West Inc2011-06-09Not applicableUs
Smart Sense Naproxen Sodiumcapsule, liquid filled220 mg/1oralKmart Corporation2011-06-22Not applicableUs
Smart Sense Naproxen Sodiumtablet220 mg/1oralKmart Corporation2010-07-15Not applicableUs
Smart Sense Naproxen Sodiumtablet, film coated220 mg/1oralKmart Corporation2010-10-08Not applicableUs
Smart Sense Naproxen Sodiumtablet, film coated220 mg/1oralKmart Corporation2010-10-01Not applicableUs
Sunmark All Day Relieftablet220 mg/1oralMc Kesson2003-08-21Not applicableUs
Sunmark All Day Relieftablet, film coated220 mg/1oralMc Kesson2003-08-11Not applicableUs
Sunmark Naproxen Sodiumcapsule, liquid filled220 mg/1oralMc Kesson2010-12-07Not applicableUs
Sunmark Naproxen Sodiumtablet, film coated220 mg/1oralMc Kesson2003-08-11Not applicableUs
Sunmark Naproxen Sodiumtablet220 mg/1oralMc Kesson2003-08-21Not applicableUs
Topcare All Day Pain Relieftablet220 mg/1oralTopco Associates LLC1997-01-14Not applicableUs
Topcare All Day Pain Relieftablet, film coated220 mg/1oralTopco Associates LLC2007-12-03Not applicableUs
Topcare All Day Pain Relieftablet, film coated220 mg/1oralTopco Associates LLC1997-01-14Not applicableUs
Topcare Naproxen Sodiumcapsule, liquid filled220 mg/1oralTopco Associates LLC2010-11-23Not applicableUs
Up and Up Naproxen Sodiumtablet, film coated220 mg/1oralTarget Corporation2009-06-24Not applicableUs
Up and Up Naproxen Sodiumcapsule, liquid filled220 mg/1oralTarget Corporation2011-01-05Not applicableUs
Up and Up Naproxen Sodiumtablet220 mg/1oralTarget Corporation2009-07-14Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Equipto - Naproxen External Cream Compounding KitkittopicalAlvix Laboratories, LLC2015-01-20Not applicableUs
International Brands
NameCompany
AlidaseLaboratorios
AlpoxenActavis
AlpronAldril
ApainMarvic
ApranaxRoche
ApronaxBayer
BonylOrion
BruproxenBruluart
Bumaflex NNycomed
CongexBuxton
DebrilMonserrat
DeproxenDrug International
DysmenalgitKrewel Meuselbach
EmoxEmo-Farm
EmoxenEMO
EurogesicSaval
FabralginaFabra
Feminax UltraBayer
FlogotoneInterpharma
GerinapGerard
HonlowPanion & BF
ImprostanFarmacoop
InflamaxFarmaceutica
InzaAlphapharm
IraxenQuilab
JinkangpuliConba
LexinaxBrisafarma
MelgarHexa
MesselxenBiomep
MobilatSTADA
NaprometinRoche
Naprosyn CRAbdi Ibrahim
Naprosyn ECRoche
Naprosyn EnteroRoche
Naprosyn SRRoche
NaprosyneRoche
NaprovalLabinco
NapruxAndromaco
NeuralpronaLba
NoflamMylan
NopainMedicef
PrexanNew Research
PriaxenRemedica
PrincepsLaser
PronaxenOrion
ProxenGrünenthal
Proxen SRoche
Proxen SRRoche
ReleveGeneral Pharma
ReproDoctor's Chemical Works
ReuxenHelcor
RiproxenBioGenet
SanaproxPerumed
SeladinYSP
ServinaproxNovartis
TarproxenPolfa Tarchomin
TicoflexIncepta
TundraFrasca
XenarElder
Xenar-CRElder
Brand mixtures
NameLabellerIngredients
Aleve NighttimeBayer Inc Consumer Care
Aleve PMBayer Health Care Consumer Care
All Day Sinus and Cold DWalgreen Company
Good Neighbor Pharmacy Sinus and Cold DAmerisource Bergen
Health Mart Sinus and Cold DMc Kesson
Leader Sinus and Cold-DCardinal Health
Motrimax 12 Hour Liquid GelsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Naproxen Capsules 200 mgAccucaps Industries Limited
Preferred Plus Sinus and Cold DKinray
Sinus and Cold DL. Perrigo Company
Sudafed 12 Hour Pressure and PainJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Sunmark Sinus and Cold DMc Kesson
TheraproxenPhysician Therapeutics Llc
Theraproxen-500Physician Therapeutics Llc
Theraproxen-90Physician Therapeutics Llc
Topcare Sinus and Cold DTopco Associates LLC
TreximetGlaxo Smith Kline Llc
Up and Up Sinus and Cold DTarget Corporation
VimovoAstra Zeneca Lp
Salts
Name/CASStructureProperties
Naproxen sodium
ThumbNot applicableDBSALT000949
Categories
UNII57Y76R9ATQ
CAS number22204-53-1
WeightAverage: 230.2592
Monoisotopic: 230.094294314
Chemical FormulaC14H14O3
InChI KeyInChIKey=CMWTZPSULFXXJA-VIFPVBQESA-N
InChI
InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
IUPAC Name
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
SMILES
COC1=CC2=C(C=C1)C=C(C=C2)[[email protected]](C)C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
KingdomOrganic compounds
Super ClassBenzenoids
ClassNaphthalenes
Sub ClassNot Available
Direct ParentNaphthalenes
Alternative Parents
Substituents
  • Naphthalene
  • Anisole
  • Alkyl aryl ether
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.
PharmacodynamicsNaproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen has analgesic and antipyretic properties. As with other NSAIDs, its mode of action is not fully understood; however, its ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect.
Mechanism of actionThe mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.
Related Articles
AbsorptionNaproxen itself is rapidly and completely absorbed from the GI tract with an in vivo bioavailability of 95%. Although naproxen itself is well absorbed, the sodium salt form is more rapidly absorbed resulting in higher peak plasma levels for a given dose. Food causes a slight decrease in the rate absorption.
Volume of distributionNot Available
Protein bindingAt therapeutic levels naproxen is greater than 99% albumin-bound.
Metabolism

Naproxen is extensively metabolized to 6-0-desmethyl naproxen and both parent and metabolites do not induce metabolizing enzymes.

SubstrateEnzymesProduct
Naproxen
O-DesmethylnaproxenDetails
Naproxen
Naproxen O-glucuronideDetails
O-Desmethylnaproxen
O-Desmethylnaproxen sulfateDetails
O-Desmethylnaproxen
O-Desmethylnaproxen acyl glucuronideDetails
O-Desmethylnaproxen
O-Desmethylnaproxen O-glucuronideDetails
Route of eliminationNot Available
Half lifeThe observed terminal elimination half-life is approximately 15 hours.
ClearanceNot Available
ToxicityORAL (LD50): Acute: 248 mg/kg [Rat]. 360 mg/kg [Mouse]. Symptoms of overdose include drowsiness, heartburn, indigestion, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Naproxen Action PathwayDrug actionSMP00120
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9948
Blood Brain Barrier+0.6881
Caco-2 permeable+0.9091
P-glycoprotein substrateNon-substrate0.586
P-glycoprotein inhibitor INon-inhibitor0.8747
P-glycoprotein inhibitor IINon-inhibitor0.8396
Renal organic cation transporterNon-inhibitor0.8615
CYP450 2C9 substrateNon-substrate0.7548
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.5715
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9521
CYP450 2C19 inhibitorNon-inhibitor0.9447
CYP450 3A4 inhibitorNon-inhibitor0.8905
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8598
Ames testAMES toxic0.5184
CarcinogenicityNon-carcinogens0.8685
BiodegradationNot ready biodegradable0.7809
Rat acute toxicity2.4579 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9588
hERG inhibition (predictor II)Non-inhibitor0.9144
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Roche palo alto llc
  • Roxane laboratories inc
  • Actavis elizabeth llc
  • Alphapharm party ltd
  • Pliva inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Amneal pharmaceuticals ny llc
  • Baxter healthcare corp anesthesia and critical care
  • Dava pharmaceuticals inc
  • Glenmark generics ltd
  • Hamilton pharmaceuticals ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Perrigo r and d co
  • Purepac pharmaceutical co
  • Teva pharmaceuticals usa
  • Watson laboratories inc
  • Westward pharmaceutical corp
  • Zydus pharmaceuticals usa inc
  • Banner pharmacaps inc
  • Stat trade inc
  • Watson laboratories inc florida
  • Bayer healthcare llc
  • Able laboratories inc
  • Contract pharmacal corp
  • Dr reddys laboratories inc
  • Dr reddys laboratories ltd
  • Hikma pharmaceuticals
  • L perrigo co
Packagers
Dosage forms
FormRouteStrength
Tablet, coatedoral220 mg/1
Capsuleoral220 mg
Tabletoral
Tabletoral200 mg/1
Tabletoral275 mg/1
Tabletoral550 mg/1
Tabletoral125 mg
Tabletoral250 mg
Tabletoral375 mg
Tabletoral275 mg
Tablet (extended-release)oral750 mg
Capsuleoral220 mg/1
Tablet, delayed releaseoral375 mg/1
Tablet, delayed releaseoral500 mg/1
Kittopical
Tablet, film coatedoral200 mg/1
Capsule, liquid filledoral220 mg/1
Tabletoral220 mg/1
Tablet, film coatedoral220 mg/1
Capsuleoral200 mg
Capsuleoral
Tablet (enteric-coated)oral500 mg
Kitoral
Tablet (extended-release)oral375 mg
Tablet (extended-release)oral500 mg
Tablet, film coated, extended releaseoral375 mg/1
Tablet, film coated, extended releaseoral500 mg/1
Tablet, film coated, extended releaseoral750 mg/1
Suspensionoral125 mg/5mL
Tabletoral250 mg/1
Tabletoral375 mg/1
Tabletoral500 mg/1
Suspensionoral25 mg
Tabletoral220 mg
Tabletoral500 mg/500mg
Kit
Capsuleoral550 mg/1
Tabletoral200 1/1
Tablet, film coatedoral275 mg/1
Tablet, film coatedoral550 mg/1
Tablet, film coated, extended releaseoral220 mg/1
Suppositoryrectal500 mg
Tablet, film coatedoral
Tablet, film coated, extended releaseoral
Tabletoral500 mg
Tablet (enteric-coated)oral250 mg
Tablet (enteric-coated)oral375 mg
Tabletoral550 mg
Kit
Tablet (immediate and delayed-release)oral
Tablet, delayed releaseoral
Prices
Unit descriptionCostUnit
Naproxen 125 mg/5ml Suspension 500ml Bottle51.5USD bottle
Naprelan 750 mg 24 Hour tablet8.87USD tablet
Naprelan cr 500 mg tablet8.5USD tablet
Naprelan cr 750 mg tablet8.02USD tablet
Naprelan cr dosecrd 500-750 mg5.98USD each
Naprelan 375 mg 24 Hour tablet4.34USD tablet
Anaprox ds 550 mg tablet3.66USD tablet
Naprelan 500 mg 24 Hour tablet3.63USD tablet
Naprelan cr 375 mg tablet3.52USD tablet
Naproxen sodium powder2.63USD g
Anaprox 275 mg tablet2.52USD tablet
Naprosyn 500 mg tablet2.42USD tablet
Naproxen powder2.26USD g
Naprosyn 500 mg tablet ec2.19USD tablet
Naprosyn 375 mg tablet1.93USD tablet
Ec-naprosyn 375 mg tablet ec1.79USD tablet
Naprosyn 250 mg tablet1.47USD tablet
Naprosyn Sr 750 mg Sustained-Release Tablet1.43USD tablet
Anaprox Ds 550 mg Tablet1.33USD tablet
Naproxen 500 mg tablet1.32USD tablet
Naproxen sodium 550 mg tablet1.32USD tablet
Naproxen DR 500 mg Enteric Coated Tabs1.3USD tab
Naproxen DR 375 mg Enteric Coated Tabs1.11USD tab
Naprosyn E 500 mg Enteric-Coated Tablet1.09USD tablet
Naproxen 375 mg tablet1.08USD tablet
Apo-Naproxen Sr 750 mg Sustained-Release Tablet1.05USD tablet
Pms-Naproxen 500 mg Suppository0.87USD suppository
Naproxen sodium 275 mg tablet0.86USD tablet
Naproxen 250 mg tablet0.79USD tablet
Apo-Napro-Na Ds 550 mg Tablet0.7USD tablet
Novo-Naprox Sodium Ds 550 mg Tablet0.7USD tablet
Anaprox 275 mg Tablet0.69USD tablet
Apo-Naproxen Ec 500 mg Enteric-Coated Tablet0.61USD tablet
Mylan-Naproxen Ec 500 mg Enteric-Coated Tablet0.61USD tablet
Novo-Naprox Ec 500 mg Enteric-Coated Tablet0.61USD tablet
Pms-Naproxen Ec 500 mg Enteric-Coated Tablet0.61USD tablet
Naprosyn E 375 mg Enteric-Coated Tablet0.6USD tablet
Naprosyn E 250 mg Enteric-Coated Tablet0.46USD tablet
Apo-Napro-Na 275 mg Tablet0.36USD tablet
Novo-Naprox Sodium 275 mg Tablet0.36USD tablet
Apo-Naproxen Ec 375 mg Enteric-Coated Tablet0.34USD tablet
Mylan-Naproxen Ec 375 mg Enteric-Coated Tablet0.34USD tablet
Novo-Naprox Ec 375 mg Enteric-Coated Tablet0.34USD tablet
Pms-Naproxen Ec 375 mg Enteric-Coated Tablet0.34USD tablet
Apo-Naproxen Ec 250 mg Enteric-Coated Tablet0.26USD tablet
Novo-Naprox Ec 250 mg Enteric-Coated Tablet0.26USD tablet
Apo-Naproxen 500 mg Tablet0.22USD tablet
Novo-Naprox 500 mg Tablet0.22USD tablet
Nu-Naprox 500 mg Tablet0.22USD tablet
Aleve 220 mg gelcap0.19USD capsule
Naprosyn 125 mg/5ml Suspension0.18USD ml
Mediproxen tablet0.17USD tablet
Apo-Naproxen 375 mg Tablet0.15USD tablet
Naproxen sodium 220 mg tablet0.15USD tablet
Novo-Naprox 375 mg Tablet0.15USD tablet
Nu-Naprox 375 mg Tablet0.15USD tablet
CVS Pharmacy all day pain rlf 220 mg tb0.12USD tablet
Wal-proxen 220 mg tablet0.12USD tablet
Apo-Naproxen 250 mg Tablet0.11USD tablet
Novo-Naprox 250 mg Tablet0.11USD tablet
Nu-Naprox 250 mg Tablet0.11USD tablet
All day pain rlf 220 mg caplet0.1USD caplet
Aleve 220 mg caplet0.09USD caplet
Aleve 220 mg tablet0.09USD tablet
Wal-proxen 220 mg caplet0.09USD tablet
Apo-Naproxen 125 mg Tablet0.08USD tablet
All day pain relief 220 mg tablet0.07USD tablet
Naprosyn 25 mg/ml Suspension0.07USD ml
Naproxen sodium 220 mg caplet0.06USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2034096 No2002-03-262011-01-14Canada
US5637320 No1994-06-102014-06-10Us
US5714504 Yes1995-08-032015-08-03Us
US5872145 Yes1998-02-142018-02-14Us
US5900424 Yes1996-11-042016-11-04Us
US6060499 Yes1998-02-142018-02-14Us
US6369085 Yes1998-11-252018-11-25Us
US6586458 Yes1998-02-142018-02-14Us
US6926907 No2003-02-282023-02-28Us
US7332183 Yes2006-04-022026-04-02Us
US7411070 Yes1998-11-252018-11-25Us
US7745466 No1998-10-132018-10-13Us
US8022095 Yes1998-02-142018-02-14Us
US8557285 No2002-05-312022-05-31Us
US8852636 No2002-05-312022-05-31Us
US8858996 No2002-05-312022-05-31Us
US8945621 No2011-10-172031-10-17Us
US9161920 No2002-05-312022-05-31Us
US9198888 No2002-05-312022-05-31Us
US9220698 No2011-03-102031-03-10Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point153 °CPhysProp
water solubility15.9 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.18HANSCH,C ET AL. (1995)
logS-4.16ADME Research, USCD
Caco2 permeability-4.83ADME Research, USCD
pKa4.15SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0511 mg/mLALOGPS
logP3.29ALOGPS
logP2.99ChemAxon
logS-3.6ALOGPS
pKa (Strongest Acidic)4.19ChemAxon
pKa (Strongest Basic)-4.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity64.85 m3·mol-1ChemAxon
Polarizability24.81 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.95 KB)
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-001i-0190000000-64cc22cce1238357760eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-0f79-0900000000-17f4e93fda31d93027a1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-0fr6-0900000000-4dd08568cff27d62d867View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-000i-0910000000-149b16cac2d80de64d8aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-00di-0900000000-e7dfead967f29853140dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-01b9-0900000000-f5f45cee188a08ef62b1View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-014i-0900000000-6c076658da1c69f1b909View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-014i-0900000000-2e1269f26d5b927bca33View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-000i-0900000000-68cd0c5a3fcc15470c14View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positivesplash10-00di-0900000000-64e5ecb5632e32f89b2dView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

DrugSyn.org

US4009197
General References
  1. Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C: Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006 Jun 3;332(7553):1302-8. [PubMed:16740558 ]
  2. Zhang J, Ding EL, Song Y: Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. JAMA. 2006 Oct 4;296(13):1619-32. Epub 2006 Sep 12. [PubMed:16968832 ]
External Links
ATC CodesG02CC02M01AE02M01AE52M01AE56M02AA12
AHFS Codes
  • 28:08.04.92
PDB EntriesNot Available
FDA labelDownload (240 KB)
MSDSDownload (75.4 KB)
Interactions
Drug Interactions
Drug
AbciximabNaproxen may increase the anticoagulant activities of Abciximab.
AcenocoumarolNaproxen may increase the anticoagulant activities of Acenocoumarol.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Naproxen is combined with Acetylsalicylic acid.
AliskirenNaproxen may decrease the antihypertensive activities of Aliskiren.
AlteplaseNaproxen may increase the anticoagulant activities of Alteplase.
AmikacinNaproxen may decrease the excretion rate of Amikacin which could result in a lower serum level and potentially a reduction in efficacy.
AmitriptylineAmitriptyline may increase the antiplatelet activities of Naproxen.
AnistreplaseNaproxen may increase the anticoagulant activities of Anistreplase.
ApixabanThe risk or severity of adverse effects can be increased when Naproxen is combined with Apixaban.
ArbekacinNaproxen may decrease the excretion rate of Arbekacin which could result in a lower serum level and potentially a reduction in efficacy.
BalsalazideNaproxen may increase the nephrotoxic activities of Balsalazide.
Citric AcidNaproxen may increase the anticoagulant activities of Citric Acid.
ColesevelamColesevelam can cause a decrease in the absorption of Naproxen resulting in a reduced serum concentration and potentially a decrease in efficacy.
CollagenaseThe risk or severity of adverse effects can be increased when Naproxen is combined with Collagenase.
CyclosporineNaproxen may increase the nephrotoxic activities of Cyclosporine.
Dabigatran etexilateNaproxen may increase the anticoagulant activities of Dabigatran etexilate.
DalteparinNaproxen may increase the anticoagulant activities of Dalteparin.
DasatinibDasatinib may increase the anticoagulant activities of Naproxen.
DeferasiroxThe risk or severity of adverse effects can be increased when Naproxen is combined with Deferasirox.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Naproxen is combined with Deoxycholic Acid.
DesmopressinThe risk or severity of adverse effects can be increased when Naproxen is combined with Desmopressin.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Naproxen.
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Naproxen.
DicoumarolNaproxen may increase the anticoagulant activities of Dicoumarol.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Naproxen.
DrospirenoneNaproxen may increase the hyperkalemic activities of Drospirenone.
Edetic AcidNaproxen may increase the anticoagulant activities of Edetic Acid.
EnoxaparinNaproxen may increase the anticoagulant activities of Enoxaparin.
EplerenoneNaproxen may decrease the antihypertensive activities of Eplerenone.
Ethyl biscoumacetateNaproxen may increase the anticoagulant activities of Ethyl biscoumacetate.
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Naproxen.
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Naproxen.
Fondaparinux sodiumNaproxen may increase the anticoagulant activities of Fondaparinux sodium.
FramycetinNaproxen may decrease the excretion rate of Framycetin which could result in a lower serum level and potentially a reduction in efficacy.
GentamicinNaproxen may decrease the excretion rate of Gentamicin which could result in a lower serum level and potentially a reduction in efficacy.
GlucosamineGlucosamine may increase the antiplatelet activities of Naproxen.
HaloperidolThe risk or severity of adverse effects can be increased when Naproxen is combined with Haloperidol.
HeparinNaproxen may increase the anticoagulant activities of Heparin.
HomoharringtonineThe risk or severity of adverse effects can be increased when Naproxen is combined with Homoharringtonine.
HydralazineNaproxen may decrease the antihypertensive activities of Hydralazine.
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Naproxen is combined with Ibritumomab.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Naproxen.
IcosapentThe risk or severity of adverse effects can be increased when Naproxen is combined with Icosapent.
InfliximabThe risk or severity of adverse effects can be increased when Infliximab is combined with Naproxen.
KanamycinNaproxen may decrease the excretion rate of Kanamycin which could result in a lower serum level and potentially a reduction in efficacy.
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Naproxen.
LimaprostLimaprost may increase the antiplatelet activities of Naproxen.
LithiumThe serum concentration of Lithium can be increased when it is combined with Naproxen.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Naproxen.
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Naproxen.
NadololNaproxen may decrease the antihypertensive activities of Nadolol.
NeomycinNaproxen may decrease the excretion rate of Neomycin which could result in a lower serum level and potentially a reduction in efficacy.
NetilmicinNaproxen may decrease the excretion rate of Netilmicin which could result in a lower serum level and potentially a reduction in efficacy.
ObinutuzumabThe risk or severity of adverse effects can be increased when Naproxen is combined with Obinutuzumab.
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Naproxen.
PamidronateThe risk or severity of adverse effects can be increased when Naproxen is combined with Pamidronate.
ParoxetineParoxetine may increase the antiplatelet activities of Naproxen.
PemetrexedThe serum concentration of Pemetrexed can be increased when it is combined with Naproxen.
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Naproxen.
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Naproxen.
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Naproxen.
PhenindioneNaproxen may increase the anticoagulant activities of Phenindione.
PhenprocoumonNaproxen may increase the anticoagulant activities of Phenprocoumon.
PorfimerNaproxen may increase the photosensitizing activities of Porfimer.
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Naproxen.
ProbenecidThe serum concentration of Naproxen can be increased when it is combined with Probenecid.
ReteplaseNaproxen may increase the anticoagulant activities of Reteplase.
RibostamycinNaproxen may decrease the excretion rate of Ribostamycin which could result in a lower serum level and potentially a reduction in efficacy.
RidogrelNaproxen may increase the anticoagulant activities of Ridogrel.
RivaroxabanNaproxen may increase the anticoagulant activities of Rivaroxaban.
SparfloxacinNaproxen may increase the neuroexcitatory activities of Sparfloxacin.
SpectinomycinNaproxen may decrease the excretion rate of Spectinomycin which could result in a lower serum level and potentially a reduction in efficacy.
StreptokinaseNaproxen may increase the anticoagulant activities of Streptokinase.
StreptomycinNaproxen may decrease the excretion rate of Streptomycin which could result in a lower serum level and potentially a reduction in efficacy.
SulodexideNaproxen may increase the anticoagulant activities of Sulodexide.
TacrolimusNaproxen may increase the nephrotoxic activities of Tacrolimus.
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Naproxen.
TenecteplaseNaproxen may increase the anticoagulant activities of Tenecteplase.
TenofovirThe risk or severity of adverse effects can be increased when Naproxen is combined with Tenofovir.
TipranavirTipranavir may increase the antiplatelet activities of Naproxen.
TobramycinNaproxen may decrease the excretion rate of Tobramycin which could result in a lower serum level and potentially a reduction in efficacy.
TorasemideNaproxen may decrease the diuretic activities of Torasemide.
TositumomabThe risk or severity of adverse effects can be increased when Naproxen is combined with Tositumomab.
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Naproxen.
TriamtereneNaproxen may decrease the antihypertensive activities of Triamterene.
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Naproxen.
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Naproxen.
UrokinaseNaproxen may increase the anticoagulant activities of Urokinase.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Naproxen.
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Naproxen.
VenlafaxineVenlafaxine may increase the antiplatelet activities of Naproxen.
VerteporfinNaproxen may increase the photosensitizing activities of Verteporfin.
Vitamin EVitamin E may increase the antiplatelet activities of Naproxen.
WarfarinNaproxen may increase the anticoagulant activities of Warfarin.
Food Interactions
  • Avoid alcohol.
  • Take with a full glass of water.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, p...
Gene Name:
PTGS2
Uniprot ID:
P35354
Molecular Weight:
68995.625 Da
References
  1. Albertini R, Aimbire F, Villaverde AB, Silva JA Jr, Costa MS: COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy. Inflamm Res. 2007 Jun;56(6):228-9. [PubMed:17607546 ]
  2. Dhir A, Naidu PS, Kulkarni SK: Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. Seizure. 2007 Dec;16(8):691-7. Epub 2007 Jul 2. [PubMed:17604186 ]
  3. Kumar P, Padi SS, Naidu PS, Kumar A: Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms. Fundam Clin Pharmacol. 2007 Jun;21(3):297-306. [PubMed:17521299 ]
  4. White WB: Cardiovascular effects of the selective cyclooxygenase-2 inhibitors. Subcell Biochem. 2007;42:145-58. [PubMed:17612049 ]
  5. Hassan-Alin M, Naesdal J, Nilsson-Pieschl C, Langstrom G, Andersson T: Lack of Pharmacokinetic Interaction between Esomeprazole and the Nonsteroidal Anti-Inflammatory Drugs Naproxen and Rofecoxib in Healthy Subjects. Clin Drug Investig. 2005;25(11):731-40. [PubMed:17532719 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. James MJ, Cook-Johnson RJ, Cleland LG: Selective COX-2 inhibitors, eicosanoid synthesis and clinical outcomes: a case study of system failure. Lipids. 2007 Sep;42(9):779-85. Epub 2007 Jun 2. [PubMed:17541796 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular Weight:
60694.12 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Banerjee T, Singh SK, Kishore N: Binding of naproxen and amitriptyline to bovine serum albumin: biophysical aspects. J Phys Chem B. 2006 Nov 30;110(47):24147-56. [PubMed:17125386 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. [PubMed:10991954 ]
  2. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. [PubMed:10220563 ]
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Drug created on June 13, 2005 07:24 / Updated on July 25, 2016 03:10