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Identification
NameIbuprofen
Accession NumberDB01050  (APRD00372)
TypeSmall Molecule
GroupsApproved
Description

Ibuprofen, a propionic acid derivative, is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.

Structure
Thumb
Synonyms
(+-)-2-(P-Isobutylphenyl)propionic acid
(+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
(+-)-Ibuprofen
(+-)-P-Isobutylhydratropic acid
(4-Isobutylphenyl)-alpha-methylacetic acid
(RS)-ibuprofen
2-(4-Isobutylphenyl)propanoic acid
4-Isobutylhydratropic acid
Adran
Advil
alpha-(4-Isobutylphenyl)propionic acid
alpha-(P-Isobutylphenyl)propionic acid
Amibufen
Anco
Anflagen
Apsifen
Bluton
Brufen
Brufort
Buburone
Butylenin
Dolgin
Dolgirid
Dolgit
Dolo-dolgit
Ebufac
Epobron
Femadon
Haltran
Ibu-attritin
Ibumetin
Ibuprocin
Ibuprofen
Ibuprophen
Ibutid
Inabrin
Inoven
Lamidon
Lebrufen
Liptan
Medipren
Motrin
Mynosedin
Nobfen
Nobgen
Nuprin
Nurofen
P-Isobutylhydratropic Acid
Para-Isobutylhydratropic Acid
Pediaprofen
Roidenin
Rufen
Seclodin
Suspren
Tabalon
Trendar
Urem
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-ibuprofen Tab 600mgtablet600 mgoralAltimed Pharma Inc.1984-12-311999-09-17Canada
Caldolorinjection800 mg/8mLintravenousCumberland Pharmaceuticals Inc.2009-06-11Not applicableUs
Caldolorsolution100 mgintravenousAlveda Pharmaceuticals Inc2012-06-15Not applicableCanada
Ibuprofen Lysinesolution10 mg/mLintravenousPrasco Laboratories2016-04-14Not applicableUs
Ibuprofen-600 Tab 600mgtablet600 mgoralPro Doc Limitee1986-12-312014-07-24Canada
Motrin Tablets 600mgtablet600 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1980-12-312004-07-22Canada
Neoprofensolution10 mg/mLintravenousRECORDATI RARE DISEASES, INC.2006-04-13Not applicableUs
Novo-profentablet600 mgoralTeva Canada Limited1985-12-31Not applicableCanada
Nu-ibuprofen Tab 600mgtablet600 mgoralNu Pharm Inc1993-12-312012-09-04Canada
PMS-ibuprofentablet600 mgoralPharmascience Inc2008-07-09Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Aliviotablet800 mg/800mgoralAlivio Medical Products, Llc2015-07-01Not applicableUs
Aliviotablet600 mg/600mgoralAlivio Medical Products, Llc2015-07-01Not applicableUs
Aliviotablet400 mg/400mgoralAlivio Medical Products, Llc2015-07-01Not applicableUs
Apo Ibuprofen Tab 600mgtablet600 mgoralApotex Inc1984-12-31Not applicableCanada
Comfort Pac With IbuprofenkitPd Rx Pharmaceuticals, Inc.2012-09-06Not applicableUs
Ibutablet800 mg/1oralBlenheim Pharmacal, Inc.2012-03-23Not applicableUs
Ibutablet400 mg/1oralDr. Reddy's Laboratories Limited2008-11-20Not applicableUs
Ibutablet400 mg/1oralbryant ranch prepack2008-11-20Not applicableUs
Ibutablet800 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-06-17Not applicableUs
Ibutablet400 mg/1oralCardinal Health2009-07-20Not applicableUs
Ibutablet600 mg/1oralLake Erie Medical DBA Quality Care Products LLC2008-11-20Not applicableUs
Ibutablet800 mg/1oralDIRECT RX2015-12-29Not applicableUs
Ibutablet600 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-07-09Not applicableUs
Ibutablet800 mg/1oralGolden State Medical Supply, Inc.2014-04-22Not applicableUs
Ibutablet400 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-07-20Not applicableUs
Ibutablet800 mg/1oralKAISER FOUNDATION HOSPITALS2012-06-05Not applicableUs
Ibutablet600 mg/1oralGolden State Medical Supply, Inc.2014-04-22Not applicableUs
Ibutablet800 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-10-19Not applicableUs
Ibutablet400 mg/1oralGolden State Medical Supply, Inc.2014-04-22Not applicableUs
Ibutablet800 mg/1oralCardinal Health2009-06-17Not applicableUs
Ibutablet600 mg/1oralKAISER FOUNDATION HOSPITALS2012-05-09Not applicableUs
Ibutablet400 mg/1oralBlenheim Pharmacal, Inc.2014-01-14Not applicableUs
Ibutablet600 mg/1oralUnit Dose Services2008-11-20Not applicableUs
Ibutablet800 mg/1oralDr. Reddy's Laboratories Limited2008-11-20Not applicableUs
Ibutablet600 mg/1oralProficient Rx LP2008-11-20Not applicableUs
Ibutablet400 mg/1oralUnit Dose Services2008-11-20Not applicableUs
Ibutablet600 mg/1oralDr. Reddy's Laboratories Limited2008-11-20Not applicableUs
Ibuprofentablet600 mg/1oralREMEDYREPACK INC.2011-04-21Not applicableUs
Ibuprofentablet600 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet, film coated800 mg/1oralMed Health Pharma, LLC2012-10-01Not applicableUs
Ibuprofentablet, film coated600 mg/1oralPolygen Pharmaceuticals LLC2011-11-28Not applicableUs
Ibuprofentablet800 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralCardinal Health2011-03-23Not applicableUs
Ibuprofentablet800 mg/1oralClinical Solutions Wholesale2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralBlenheim Pharmacal, Inc.2010-11-03Not applicableUs
Ibuprofentablet, film coated400 mg/1oralGranules India Limited2015-09-21Not applicableUs
Ibuprofentablet400 mg/1oralMc Kesson Packaging Serivces A Business Unit Of Mc Kesson Corporation2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralContract Pharmacy Services Pa2010-04-12Not applicableUs
Ibuprofentablet, film coated600 mg/1oralAscend Laboratories, LLC2015-12-21Not applicableUs
Ibuprofentablet600 mg/1oralPreferred Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralMc Kesson Contract Packaging2012-01-05Not applicableUs
Ibuprofentablet200 mg/1oralREMEDYREPACK INC.2010-12-082015-12-29Us
Ibuprofentablet800 mg/1oralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
Ibuprofentablet, film coated800 mg/1oralSTAT Rx USA LLC2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralApotheca, Inc.1991-02-11Not applicableUs
Ibuprofentablet200 mg/1oralApotheca, Inc2014-02-14Not applicableUs
Ibuprofentablet800 mg/1oralAidarex Pharmaceuticals LLC2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralREMEDYREPACK INC.2011-04-26Not applicableUs
Ibuprofentablet600 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet, film coated400 mg/301oralNorthwind Pharmaceuticals2014-05-20Not applicableUs
Ibuprofentablet400 mg/1oralH.J. Harkins Company, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofensuspension100 mg/5mLoralCardinal Health2012-08-16Not applicableUs
Ibuprofensuspension100 mg/5mLoralPharmaceutical Associates, Inc.2004-09-23Not applicableUs
Ibuprofentablet600 mg/1oralGolden State Medical Supply, Inc.2009-11-23Not applicableUs
Ibuprofentablet, film coated800 mg/1oralGranules India Limited2015-09-21Not applicableUs
Ibuprofentablet800 mg/1oralMc Kesson Packaging Serivces A Business Unit Of Mc Kesson Corporation2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralContract Pharmacy Services Pa2009-09-22Not applicableUs
Ibuprofentablet400 mg/1oralAmerican Health Packaging2013-10-14Not applicableUs
Ibuprofentablet400 mg/1oralPreferred Pharmaceuticals, Inc.2012-09-28Not applicableUs
Ibuprofentablet400 mg/1oralQualitest Pharmaceuticals2009-11-232015-12-29Us
Ibuprofentablet, film coated600 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Ibuprofentablet, film coated400 mg/1oralRebel Distributors Corp2009-06-10Not applicableUs
Ibuprofentablet600 mg/1oralRebel Distributors Corp2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralBlenheim Pharmacal, Inc.2014-02-04Not applicableUs
Ibuprofentablet800 mg/1oralAphena Pharma Solutions Tennessee, Inc.2009-11-23Not applicableUs
Ibuprofentablet, film coated600 mg/1oralTIME CAP LABORATORIES, INC2015-12-30Not applicableUs
Ibuprofentablet800 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralREMEDYREPACK INC.2013-07-16Not applicableUs
Ibuprofentablet400 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Ibuprofentablet600 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-11-23Not applicableUs
Ibuprofentablet, film coated200 mg/1oralREMEDYREPACK INC.2015-02-13Not applicableUs
Ibuprofentablet600 mg/1oralMed Vantx, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralAscend Laboratories, LLC2009-02-06Not applicableUs
Ibuprofentablet600 mg/1oralLegacy Pharmaceutical Packaging2011-02-28Not applicableUs
Ibuprofentablet, film coated400 mg/1oralAmneal Pharmaceuticals of New York, LLC2014-04-01Not applicableUs
Ibuprofentablet600 mg/1oralAmerican Health Packaging2011-03-232015-12-29Us
Ibuprofentablet, film coated400 mg/400mgoralWestminster Pharmaceuticals, Llc2016-03-28Not applicableUs
Ibuprofentablet600 mg/1oralBlenheim Pharmacal, Inc.2010-09-15Not applicableUs
Ibuprofentablet600 mg/1oralDIRECT RX2015-01-01Not applicableUs
Ibuprofentablet600 mg/1oralContract Pharmacy Services Pa2010-04-14Not applicableUs
Ibuprofentablet, film coated400 mg/1oralAscend Laboratories, LLC2015-12-21Not applicableUs
Ibuprofentablet400 mg/1oralPreferred Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralLife Line Home Care Services, Inc.2012-02-13Not applicableUs
Ibuprofentablet800 mg/1oralNorthwind Pharmaceuticals2015-11-04Not applicableUs
Ibuprofentablet600 mg/1oralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
Ibuprofentablet, film coated600 mg/1oralSTAT Rx USA LLC2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralHHS/Program Support Center/Supply Service Center2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralREMEDYREPACK INC.2011-04-18Not applicableUs
Ibuprofentablet400 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralIngenus Pharmaceuticals, LLC2015-10-02Not applicableUs
Ibuprofentablet, film coated400 mg/1oralPolygen Pharmaceuticals LLC2011-11-28Not applicableUs
Ibuprofentablet600 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralClinical Solutions Wholesale2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralAphena Pharma Solutions Tennessee, Inc.2009-11-23Not applicableUs
Ibuprofentablet, film coated400 mg/1oralTIME CAP LABORATORIES, INC2015-12-30Not applicableUs
Ibuprofentablet800 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralREMEDYREPACK INC.2013-05-30Not applicableUs
Ibuprofentablet800 mg/1oralAmneal Pharmaceuticals of New York, LLC2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralDispensing Solutions, Inc.2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralSt Marys Medical Park Pharmacy2013-07-11Not applicableUs
Ibuprofentablet, film coated200 mg/1oralbryant ranch prepack2004-01-01Not applicableUs
Ibuprofentablet400 mg/1oralMed Vantx, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralRed Pharm Drug Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralLegacy Pharmaceutical Packaging2011-02-28Not applicableUs
Ibuprofentablet, coated800 mg/1oralBiomes Pharmaceuticals LLC2009-05-02Not applicableUs
Ibuprofentablet400 mg/1oralAmerican Health Packaging2011-03-232015-12-29Us
Ibuprofentablet800 mg/1oralBi Coastal Pharma International Llc2016-04-14Not applicableUs
Ibuprofensuspension100 mg/5mLoralSTAT Rx USA LLC2004-12-08Not applicableUs
Ibuprofentablet600 mg/1oralBlenheim Pharmacal, Inc.2014-02-04Not applicableUs
Ibuprofentablet600 mg/1oralBlenheim Pharmacal, Inc.2010-09-08Not applicableUs
Ibuprofensuspension100 mg/5mLoralVista Pharm, Inc.2012-08-16Not applicableUs
Ibuprofentablet800 mg/1oralAscend Laboratories, LLC2012-02-22Not applicableUs
Ibuprofentablet800 mg/1oralPreferred Pharmaceuticals, Inc.2008-11-20Not applicableUs
Ibuprofentablet800 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-02-22Not applicableUs
Ibuprofentablet400 mg/1oralMARKSANS PHARMA LIMITED2011-02-28Not applicableUs
Ibuprofentablet800 mg/1oralAv Kare, Inc.2013-01-10Not applicableUs
Ibuprofentablet800 mg/1oralPerrigo Pharmaceuticals Company2006-05-08Not applicableUs
Ibuprofentablet600 mg/1oralREMEDYREPACK INC.2010-11-23Not applicableUs
Ibuprofentablet400 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralIngenus Pharmaceuticals, LLC2015-10-02Not applicableUs
Ibuprofentablet400 mg/1oralREMEDYREPACK INC.2014-06-05Not applicableUs
Ibuprofentablet400 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet, film coated400 mg/1oralCardinal Health2009-06-10Not applicableUs
Ibuprofentablet400 mg/1oralClinical Solutions Wholesale2009-11-23Not applicableUs
Ibuprofensuspension100 mg/5mLoralActavis Pharma, Inc.2002-09-27Not applicableUs
Ibuprofentablet600 mg/1oralProficient Rx LP2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralTYA Pharmaceuticals2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralRed Pharm Drug Inc.2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralKeltman Pharmaceuticals Inc.2007-08-24Not applicableUs
Ibuprofentablet, coated600 mg/1oralBiomes Pharmaceuticals LLC2009-05-02Not applicableUs
Ibuprofentablet400 mg/1oralCardinal Health2009-11-232015-12-29Us
Ibuprofentablet600 mg/1oralBi Coastal Pharma International Llc2016-04-14Not applicableUs
Ibuprofentablet800 mg/1oralSTAT Rx USA LLC2008-11-20Not applicableUs
Ibuprofentablet800 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralBlenheim Pharmacal, Inc.2010-04-28Not applicableUs
Ibuprofentablet600 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralREMEDYREPACK INC.2011-03-11Not applicableUs
Ibuprofentablet800 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralREMEDYREPACK INC.2013-05-13Not applicableUs
Ibuprofentablet600 mg/1oralAmneal Pharmaceuticals of New York, LLC2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralPhysicians Total Care, Inc.1994-12-20Not applicableUs
Ibuprofentablet800 mg/1oralCardinal Health2009-11-23Not applicableUs
Ibuprofentablet, film coated800 mg/1oralDIRECT RX2014-01-01Not applicableUs
Ibuprofentablet600 mg/1oralDispensing Solutions, Inc.2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralAscend Laboratories, LLC2012-02-22Not applicableUs
Ibuprofentablet600 mg/1oralPreferred Pharmaceuticals, Inc.2008-11-20Not applicableUs
Ibuprofentablet600 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-02-22Not applicableUs
Ibuprofentablet800 mg/1oralREMEDYREPACK INC.2013-04-032016-03-12Us
Ibuprofentablet600 mg/1oralAv Kare, Inc.2013-01-10Not applicableUs
Ibuprofentablet400 mg/1oralMedsource Pharmaceuticals2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-21Not applicableUs
Ibuprofentablet400 mg/1oralIngenus Pharmaceuticals, LLC2015-10-02Not applicableUs
Ibuprofentablet600 mg/1oralREMEDYREPACK INC.2014-06-05Not applicableUs
Ibuprofentablet, film coated600 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Ibuprofentablet, film coated800 mg/1oralCardinal Health2009-06-10Not applicableUs
Ibuprofentablet800 mg/1oralMajor Pharmaceuticals2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralProficient Rx LP2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Ibuprofentablet800 mg/1oralRed Pharm Drug Inc.2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralKeltman Pharmaceuticals Inc.2007-08-24Not applicableUs
Ibuprofentablet, coated400 mg/1oralBiomes Pharmaceuticals LLC2009-05-02Not applicableUs
Ibuprofentablet600 mg/1oralCardinal Health2009-11-232015-12-29Us
Ibuprofentablet400 mg/1oralBi Coastal Pharma International Llc2016-04-14Not applicableUs
Ibuprofentablet600 mg/1oralSTAT Rx USA LLC2008-11-20Not applicableUs
Ibuprofentablet800 mg/1oralRx Change Co.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralBlenheim Pharmacal, Inc.2010-03-10Not applicableUs
Ibuprofentablet800 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralREMEDYREPACK INC.2011-08-11Not applicableUs
Ibuprofentablet600 mg/1oralA S Medication Solutions Llc2012-02-22Not applicableUs
Ibuprofentablet400 mg/1oralREMEDYREPACK INC.2013-02-11Not applicableUs
Ibuprofentablet400 mg/1oralAmneal Pharmaceuticals of New York, LLC2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralPhysicians Total Care, Inc.1997-05-08Not applicableUs
Ibuprofentablet400 mg/1oralCardinal Health2009-11-23Not applicableUs
Ibuprofentablet, film coated600 mg/1oralDIRECT RX2014-01-01Not applicableUs
Ibuprofentablet400 mg/1oralbryant ranch prepack2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralDispensing Solutions, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralAscend Laboratories, LLC2012-02-22Not applicableUs
Ibuprofentablet400 mg/1oralPreferred Pharmaceuticals, Inc.2008-11-20Not applicableUs
Ibuprofensuspension100 mg/5mLoralRebel Distributors Corp2004-09-23Not applicableUs
Ibuprofentablet400 mg/1oralAv Kare, Inc.2013-01-10Not applicableUs
Ibuprofentablet800 mg/1oralBlenheim Pharmacal, Inc.2015-06-03Not applicableUs
Ibuprofentablet800 mg/1oralMedsource Pharmaceuticals2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralUnit Dose Services2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralREMEDYREPACK INC.2013-11-20Not applicableUs
Ibuprofentablet600 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Ibuprofentablet, film coated600 mg/1oralCardinal Health2009-06-10Not applicableUs
Ibuprofentablet600 mg/1oralMajor Pharmaceuticals2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralProficient Rx LP2012-02-22Not applicableUs
Ibuprofentablet800 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Ibuprofentablet800 1/1oralContract Pharmacy Services Pa2010-04-14Not applicableUs
Ibuprofentablet800 mg/1oralAmerican Health Packaging2013-10-14Not applicableUs
Ibuprofentablet800 mg/1oralPreferred Pharmaceuticals, Inc.2012-09-28Not applicableUs
Ibuprofentablet800 mg/1oralQualitest Pharmaceuticals2009-11-232015-12-29Us
Ibuprofentablet400 mg/1oralSTAT Rx USA LLC2008-11-20Not applicableUs
Ibuprofentablet600 mg/1oralRx Change Co.2014-11-09Not applicableUs
Ibuprofentablet400 mg/1oralBlenheim Pharmacal, Inc.2014-02-04Not applicableUs
Ibuprofentablet600 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralREMEDYREPACK INC.2011-07-12Not applicableUs
Ibuprofentablet600 mg/1oralA S Medication Solutions Llc2012-02-22Not applicableUs
Ibuprofentablet800 mg/1oralNorthwind Pharmaceuticals2014-06-01Not applicableUs
Ibuprofentablet800 mg/1oralH.J. Harkins Company, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralPhysicians Total Care, Inc.1997-02-20Not applicableUs
Ibuprofentablet, film coated800 mg/1oralRebel Distributors Corp2009-06-10Not applicableUs
Ibuprofentablet400 mg/1oralRebel Distributors Corp2009-11-23Not applicableUs
Ibuprofensuspension100 mg/5mLoralPerrigo New York Inc2004-12-08Not applicableUs
Ibuprofentablet600 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-21Not applicableUs
Ibuprofentablet400 mg/1oralREMEDYREPACK INC.2013-09-19Not applicableUs
Ibuprofentablet, film coated800 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Ibuprofentablet400 mg/1oralMajor Pharmaceuticals2009-11-23Not applicableUs
Ibuprofentablet, film coated400 mg/1oralDIRECT RX2014-01-01Not applicableUs
Ibuprofentablet800 mg/1oralbryant ranch prepack2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralDispensing Solutions, Inc.2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralAscend Laboratories, LLC2009-02-06Not applicableUs
Ibuprofensuspension100 mg/5mLoralPreferred Pharmaceuticals, Inc2011-07-05Not applicableUs
Ibuprofentablet, film coated800 mg/1oralAmneal Pharmaceuticals of New York, LLC2014-04-01Not applicableUs
Ibuprofentablet, film coated800 mg/800mgoralWestminster Pharmaceuticals, Llc2016-03-28Not applicableUs
Ibuprofentablet600 mg/1oralAidarex Pharmaceuticals LLC2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralApotheca, Inc.1996-12-23Not applicableUs
Ibuprofentablet800 mg/1oralREMEDYREPACK INC.2011-04-21Not applicableUs
Ibuprofentablet600 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet, film coated600 mg/1oralNorthwind Pharmaceuticals, LLC2014-10-28Not applicableUs
Ibuprofentablet, film coated800 mg/1oralPolygen Pharmaceuticals LLC2011-11-28Not applicableUs
Ibuprofentablet800 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralCardinal Health2012-02-22Not applicableUs
Ibuprofentablet400 mg/1oralGolden State Medical Supply, Inc.2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralBlenheim Pharmacal, Inc.2010-12-20Not applicableUs
Ibuprofentablet, film coated600 mg/1oralGranules India Limited2015-09-21Not applicableUs
Ibuprofentablet600 mg/1oralMc Kesson Packaging Serivces A Business Unit Of Mc Kesson Corporation2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralContract Pharmacy Services Pa2009-09-22Not applicableUs
Ibuprofentablet, film coated800 mg/1oralAscend Laboratories, LLC2015-12-21Not applicableUs
Ibuprofentablet800 mg/1oralPreferred Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralMc Kesson Contract Packaging2011-12-22Not applicableUs
Ibuprofentablet, film coated400 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Ibuprofentablet800 mg/1oralGolden State Medical Supply, Inc.2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralProficient Rx LP2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralAltura Pharmaceuticals, Inc.2010-01-01Not applicableUs
Ibuprofentablet800 1/1oralContract Pharmacy Services Pa2009-10-01Not applicableUs
Ibuprofentablet600 mg/1oralAmerican Health Packaging2013-10-14Not applicableUs
Ibuprofentablet600 mg/1oralPreferred Pharmaceuticals, Inc.2012-09-28Not applicableUs
Ibuprofentablet600 mg/1oralQualitest Pharmaceuticals2009-11-232015-12-29Us
Ibuprofentablet, film coated800 mg/1oralMajor Pharmaceuticals2009-06-10Not applicableUs
Ibuprofentablet800 mg/1oralApotheca, Inc.2009-02-09Not applicableUs
Ibuprofentablet400 mg/1oralAidarex Pharmaceuticals LLC2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralBlenheim Pharmacal, Inc.2012-08-23Not applicableUs
Ibuprofentablet400 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralREMEDYREPACK INC.2011-07-08Not applicableUs
Ibuprofentablet600 mg/1oralA S Medication Solutions Llc2012-02-22Not applicableUs
Ibuprofentablet600 mg/1oralNorthwind Pharmaceuticals, LLC2014-08-14Not applicableUs
Ibuprofentablet600 mg/1oralH.J. Harkins Company, Inc.2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralA S Medication Solutions Llc2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralCardinal Health2013-10-14Not applicableUs
Ibuprofentablet, film coated800 mg/1oralKAISER FOUNDATION HOSPITALS2009-11-30Not applicableUs
Ibuprofentablet, film coated600 mg/1oralRebel Distributors Corp2009-06-10Not applicableUs
Ibuprofentablet800 mg/1oralRebel Distributors Corp2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs
Ibuprofentablet600 mg/1oralAphena Pharma Solutions Tennessee, Inc.2009-11-23Not applicableUs
Ibuprofentablet, film coated800 mg/1oralTIME CAP LABORATORIES, INC2015-12-30Not applicableUs
Ibuprofentablet, film coated600 mg/1oralREMEDYREPACK INC.2013-07-16Not applicableUs
Ibuprofentablet, film coated400 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Ibuprofentablet400 mg/1oralPd Rx Pharmaceuticals, Inc.2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-11-23Not applicableUs
Ibuprofentablet400 mg/1oralREMEDYREPACK INC.2015-12-30Not applicableUs
Ibuprofentablet600 mg/1oralbryant ranch prepack2009-11-23Not applicableUs
Ibuprofentablet800 mg/1oralMed Vantx, Inc.2009-11-23Not applicableUs
Ibuprofentablet600 mg/1oralAscend Laboratories, LLC2009-02-06Not applicableUs
Ibuprofentablet800 mg/1oralLegacy Pharmaceutical Packaging2011-02-28Not applicableUs
Ibuprofentablet, film coated600 mg/1oralAmneal Pharmaceuticals of New York, LLC2014-04-01Not applicableUs
Ibuprofentablet800 mg/1oralAmerican Health Packaging2011-03-242015-12-29Us
Ibuprofentablet, film coated600 mg/600mgoralWestminster Pharmaceuticals, Llc2016-03-28Not applicableUs
Ibuprofen Immediate Releasetablet400 mg/1oralShasun Pharmaceuticals Limited2009-02-05Not applicableUs
Ibuprofen Immediate Releasetablet600 mg/1oralShasun Pharmaceuticals Limited2009-02-05Not applicableUs
Ibuprofen Immediate Releasetablet800 mg/1oralShasun Pharmaceuticals Limited2009-02-05Not applicableUs
Ibuprofen Lysinesolution10 mg/mLintravenousX Gen Pharmaceuticals, Inc.2016-04-08Not applicableUs
Perrigo Ibuprofentablet600 mg/1oralPerrigo Pharmaceuticals Company2006-03-16Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
7 Select Childrens Ibuprofensuspension100 mg/5mLoral7 Eleven2014-08-05Not applicableUs
7 Select Ibuprofentablet, coated200 mg/1oral7 Eleven2014-05-13Not applicableUs
7 Select Ibuprofentablet, film coated200 mg/1oral7 Eleven2014-08-07Not applicableUs
Actiprofen - Caplet 200mgtablet200 mgoralBayer Inc Consumer Care1996-12-311999-11-03Canada
Adviltablet, coated200 mg/1oralPfizer Consumer Healthcare1984-05-18Not applicableUs
Adviltablet, coated200 mg/1oralPfizer Consumer Healthcare1984-05-18Not applicableUs
Adviltablet, coated256 mg/1oralPfizer Consumer Healthcare2013-07-08Not applicableUs
Adviltablet, coated200 mg/1oralPfizer Consumer Healthcare1984-05-18Not applicableUs
Adviltablet, coated200 mg/1oralPfizer Consumer Healthcare1984-05-18Not applicableUs
Adviltablet, coated200 mg/1oralPfizer Consumer Healthcare1984-05-18Not applicableUs
Adviltablet, coated200 mg/1oralPfizer Consumer Healthcare1984-05-18Not applicableUs
Adviltablet, coated200 mg/1oralPfizer Consumer Healthcare1984-05-18Not applicableUs
Advilcapsule, liquid filled200 mg/1oralPfizer Consumer Healthcare1995-04-10Not applicableUs
Advilcapsule, liquid filled200 mg/1oralPfizer Consumer Healthcare1995-04-10Not applicableUs
Adviltablet, coated200 mg/1oralLil' Drug Store Products, Inc.2010-02-22Not applicableUs
Adviltablet, coated200 mg/1oralPfizer Consumer Healthcare1984-05-18Not applicableUs
Adviltablet, coated256 mg/1oralPfizer Consumer Healthcare2013-07-08Not applicableUs
Advil Arthritis Paincapsule400 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2014-07-07Not applicableCanada
Advil Capletstablet200 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1992-12-31Not applicableCanada
Advil Extra Strength Capletstablet400 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2002-05-14Not applicableCanada
Advil Extra Strength Liqui-gelscapsule400 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2004-06-21Not applicableCanada
Advil Gel Capletstablet200 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1997-05-05Not applicableCanada
Advil Liqui-gelscapsule200 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2000-10-02Not applicableCanada
Advil Liquigelscapsule, liquid filled200 mg/1oralLil' Drug Store Products, Inc2012-05-01Not applicableUs
Advil Migrainecapsule, liquid filled200 mg/1oralPfizer Consumer Healthcare2000-03-16Not applicableUs
Advil Muscle and Jointtablet400 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2011-11-07Not applicableCanada
Advil Pediatric Dropssuspension40 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2000-10-23Not applicableCanada
Advil Pediatric Drops Fever From Colds Or Flususpension40 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2010-08-06Not applicableCanada
Advil Tabletstablet200 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1993-12-31Not applicableCanada
Alti-ibuprofen Tab 300mgtablet300 mgoralAltimed Pharma Inc.1983-12-311999-09-17Canada
Alti-ibuprofen Tab 400mgtablet400 mgoralAltimed Pharma Inc.1983-12-311999-09-17Canada
Apo Ibuprofen Tab 300mgtablet300 mgoralApotex Inc1983-12-31Not applicableCanada
Apo Ibuprofen Tab 400mgtablet400 mgoralApotex Inc1983-12-31Not applicableCanada
Apo-ibuprofen Tab 200mgtablet200 mgoralApotex Inc1984-12-31Not applicableCanada
Aprofen Regular Strengthtablet200 mg/1oralA P J Laboratories Limited2013-02-21Not applicableUs
Babies R Us Ibuprofensuspension100 mg/5mLoralToys"R"Us, Inc.2010-12-01Not applicableUs
Babies R Us Infants Ibuprofensuspension/ drops50 mg/1.25mLoralToys"R"Us, Inc.2010-12-01Not applicableUs
Being Well Ibuprofensuspension100 mg/5mLoralSave A Lot Food Stores Ltd2006-02-25Not applicableUs
Berkley and Jensen Ibuprofentablet200 mg/1oralBJWC2007-06-20Not applicableUs
Berkley and Jensen Ibuprofentablet, film coated200 mg/1oralBJWC2009-01-15Not applicableUs
Berkley and Jensen Ibuprofen Childrens Dye Freesuspension100 mg/5mLoralBJWC2010-01-07Not applicableUs
Care One Ibuprofentablet, chewable100 mg/1oralAmerican Sales Company2004-09-13Not applicableUs
Care One Ibuprofentablet, coated200 mg/1oralAmerican Sales Company2004-04-13Not applicableUs
Care One Ibuprofentablet200 mg/1oralAmerican Sales Company2004-04-13Not applicableUs
Care One Ibuprofensuspension/ drops50 mg/1.25mLoralAmerican Sales Company2006-05-16Not applicableUs
Care One Ibuprofensuspension100 mg/5mLoralAmerican Sales Company2004-04-28Not applicableUs
Care One Ibuprofen Childrenssuspension100 mg/5mLoralAmerican Sales Company2004-05-04Not applicableUs
Care One Ibuprofen Childrenssuspension100 mg/5mLoralAmerican Sales Company2004-04-28Not applicableUs
Care One Ibuprofen Childrenssuspension100 mg/5mLoralAmerican Sales Company2008-08-01Not applicableUs
Care One Ibuprofen Ibtablet, coated200 mg/1oralAmerican Sales Company2006-05-09Not applicableUs
Care One Ibuprofen Ibtablet, film coated200 mg/1oralAmerican Sales Company2006-05-24Not applicableUs
Care One Ibuprofen Infantssuspension50 mg/1.25mLoralAmerican Sales Company2004-05-11Not applicableUs
Care One Ibuprofen Junior Strengthtablet, chewable100 mg/1oralAmerican Sales Company2010-05-21Not applicableUs
Careall Ibuprofentablet200 mg/1oralNew World Imports2016-03-15Not applicableUs
Careone Ibuprofen Junior Strengthtablet, chewable100 mg/1oralAmerican Sales Company2010-05-21Not applicableUs
Cedaprintablet200 mg/1oralNorth Safety Products LLC2012-03-07Not applicableUs
Children's Advilsuspension100 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc1997-11-03Not applicableCanada
Children's Advil Chewable Tabletstablet (chewable)50 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada IncNot applicableNot applicableCanada
Children's Advil Fever From Colds Or Flususpension100 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2009-11-05Not applicableCanada
Children's Europrofensuspension100 mgoralPendopharm Division Of De Pharmascience Inc2011-02-14Not applicableCanada
Children's Ibuprofen Suspensionsuspension100 mgoralPerrigo International2007-08-30Not applicableCanada
Children's Motrinsuspension100 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1997-12-102002-07-19Canada
Children's Motrin Chewable Tablet 50mgtablet50 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2001-02-122005-07-22Canada
Children's Motrin Chewable Tabletstablet50 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2003-05-14Not applicableCanada
Children's Motrin Suspensionsuspension100 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2000-09-15Not applicableCanada
Childrens Advilsuspension100 mg/5mLoralPfizer Consumer Healthcare1996-06-27Not applicableUs
Childrens Advilsuspension100 mg/5mLoralPfizer Consumer Healthcare2010-06-28Not applicableUs
Childrens Advilsuspension100 mg/5mLoralPfizer Consumer Healthcare1996-06-27Not applicableUs
Childrens Advilsuspension100 mg/5mLoralPfizer Consumer Healthcare2014-06-01Not applicableUs
Childrens Advilsuspension100 mg/5mLoralPfizer Consumer Healthcare1996-06-27Not applicableUs
Childrens Advilsuspension100 mg/5mLoralPfizer Consumer Healthcare2012-11-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralFred's Inc.2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralFamily Dollar Services Inc.2006-08-04Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralKinray Inc.2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Consortium, LLC2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralActavis Mid Atlantic LLC2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralCardinal Health2004-04-13Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralCVS Pharmacy2014-02-09Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Marketing Association Inc.2010-03-04Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralWalgreen Company2010-05-24Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralPrecision Dose Inc.2004-04-13Not applicableUs
Childrens Ibuprofensolution100 mg/5mLoralNash Finch Company (Our Family)2006-07-18Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralMeijer Distribution Inc1994-11-21Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralPharmaceutical Associates, Inc.2014-12-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralActavis Mid Atlantic LLC2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralFred's Inc.2008-03-24Not applicableUs
Childrens Ibuprofensolution100 mg/5mLoralPreferred Plus (Kinray)2014-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralKinray Inc.2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Consortium, LLC2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralRite Aid2008-03-20Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Marketing Association Inc.2014-10-10Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralValu Merchandisers Company2008-01-16Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralPreferred Pharmaceuticals, Inc2011-08-24Not applicableUs
Childrens Ibuprofensolution100 mg/5mLoralNash Finch Company (Our Family)2006-07-18Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralStephen L. La France Pharmacy, Inc.2006-05-25Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralMeijer Distribution Inc2014-04-23Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralWalgreen Company2010-05-24Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralActavis Mid Atlantic LLC2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralKinray Inc.2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Consortium, LLC2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralShopko Stores Operating Co., LLC2013-07-30Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralValu Merchandisers Company2012-05-23Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralPerrigo New York Inc2014-04-09Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralKinray Inc.2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Consortium, LLC2012-12-06Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralWal Mart Stores, Inc.2012-05-17Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralFamily Dollar Services Inc.2012-02-23Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralValu Merchandisers Company2006-10-09Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralPerrigo New York Inc2014-04-09Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralWal Mart Stores, Inc.2012-05-17Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralCVS Pharmacy2014-01-29Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralProficient Rx LP2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Marketing Association Inc.2008-01-10Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralRite Aid Corporation2002-05-10Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralStephen L. La France Pharmacy, Inc.2008-02-13Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralWalgreen Company2010-05-24Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralRugby Laboratories2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralWestern Family Foods Inc2002-10-07Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralH E B2002-06-19Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralActavis Mid Atlantic LLC2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Consortium, LLC2006-06-01Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralRugby Laboratories2015-09-15Not applicableUs
Childrens Ibuprofensuspension200 mg/10mLoralCardinal Health2006-09-14Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralChain Drug Marketing Association Inc.2006-10-09Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralWalgreen Company2010-05-24Not applicableUs
Childrens Ibuprofenliquid100 mg/5mLoralWestern Family Foods Inc2008-08-18Not applicableUs
Childrens Ibuprofensuspension200 mg/10mLoralPrecision Dose Inc.2006-09-14Not applicableUs
Childrens Ibuprofensuspension100 mg/5mLoralSafeway2002-05-02Not applicableUs
Childrens Ibuprofen 100 Dye Freesuspension100 mg/5mLoralWalgreen Company2014-02-24Not applicableUs
Childrens Ibuprofen Oral Suspensionsuspension100 mg/5mLoralMeijer Distribution Inc2002-03-19Not applicableUs
Childrens Motrinsuspension100 mg/5mLoralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2016-01-25Not applicableUs
Childrens Motrinsuspension100 mg/5mLoralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2016-01-25Not applicableUs
Childrens Motrinsuspension100 mg/5mLoralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division1995-09-01Not applicableUs
Childrens Motrinsuspension100 mg/5mLoralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2001-09-01Not applicableUs
Circle K Ibuprofentablet, coated200 mg/1oralLil' Drug Store Products, Inc2014-11-01Not applicableUs
Clear Choice Ibuprofentablet200 mg/1oralAthlete's Needs Inc2012-10-09Not applicableUs
Concentrated Ibuprofensuspension50 mg/1.25mLoralTris Phrama Inc2012-11-06Not applicableUs
Counteract Ibtablet, coated200 mg/1oralMelaleuca, Inc2011-04-30Not applicableUs
Counteract Ibtablet, film coated200 mg/1oralMelaleuca, Inc.2010-03-18Not applicableUs
Cvs Pharmacy Ibuprofencapsule, liquid filled200 mg/1oralCVS Pharmacy2009-12-04Not applicableUs
Dg Health Ibuprofentablet, film coated200 mg/1oralDolgencorp, LLC2009-10-03Not applicableUs
Dg Health Ibuprofensuspension100 mg/5mLoralDolgencorp Inc2010-02-06Not applicableUs
Dg Health Ibuprofentablet, coated200 mg/1oralDolgencorp, LLC2010-02-01Not applicableUs
Dg Health Ibuprofensuspension50 mg/1.25mLoralDolgencorp, LLC2010-02-22Not applicableUs
Dg Health Ibuprofensuspension/ drops50 mg/1.25mLoralDolgencorp, LLC2010-04-27Not applicableUs
Direct Safety Ibuprofentablet, film coated200 mg/1oralConney Safety Products, LLC2013-05-03Not applicableUs
Direct Safety Ibuprofentablet, coated200 mg/1oralConney Safety Products, LLC2014-11-17Not applicableUs
Direct Safety Ibuprofentablet, coated200 mg/1oralConney Safety Products, LLC2016-02-01Not applicableUs
Dolextablet200 mg/1oralPharmadel LLC2013-03-25Not applicableUs
Dover Addaprintablet, coated200 mg/1oralUnifirst First Aid Corporation2016-02-01Not applicableUs
Dover Addaprintablet, coated200 mg/1oralUnifirst First Aid Corporation2014-11-17Not applicableUs
Dover Addaprintablet, film coated200 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Dragon Tabstablet200 mg/1oralGenomma Lab Usa2015-04-17Not applicableUs
Dye Free Childrens Ibuprofensuspension100 mg/5mLoralPrecision Dose Inc.2015-08-26Not applicableUs
Dye Free Ibuprofentablet200 mg/1oralWALGREEN CO.2004-03-11Not applicableUs
Equaline Childrens Ibuprofensuspension100 mg/5mLoralSupervalu Inc2004-09-24Not applicableUs
Equaline Ibuprofentablet, film coated200 mg/1oralSupervalu Inc2006-04-28Not applicableUs
Equaline Ibuprofentablet, coated200 mg/1oralSupervalu Inc2006-03-07Not applicableUs
Equaline Ibuprofensuspension100 mg/5mLoralSupervalu Inc2010-09-27Not applicableUs
Equaline Ibuprofensuspension/ drops50 mg/1.25mLoralSupervalu Inc2004-12-22Not applicableUs
Equaline Ibuprofensuspension50 mg/1.25mLoralSupervalu Inc2004-09-07Not applicableUs
Equaline Ibuprofentablet, coated200 mg/1oralSupervalu Inc2004-08-17Not applicableUs
Equaline Ibuprofentablet200 mg/1oralSupervalu Inc2004-08-05Not applicableUs
Equaline Ibuprofentablet, chewable100 mg/1oralSupervalu Inc2011-05-04Not applicableUs
Equaline Ibuprofen Childrenssuspension100 mg/5mLoralSupervalu Inc2004-08-30Not applicableUs
Equaline Ibuprofen Childrenssuspension100 mg/5mLoralSupervalu Inc2004-09-24Not applicableUs
Equaline Ibuprofen Childrenssuspension100 mg/5mLoralSupervalu Inc2004-10-07Not applicableUs
Equate Ibuprofentablet200 mg/1oralWal Mart Stores Inc1989-10-15Not applicableUs
Equate Ibuprofentablet, film coated200 mg/1oralWal Mart Stores Inc2013-08-13Not applicableUs
Equate Ibuprofentablet, chewable100 mg/1oralWal Mart Stores Inc2011-10-25Not applicableUs
Equate Ibuprofencapsule, liquid filled200 mg/1oralWalmart stores Inc2014-07-02Not applicableUs
Equate Ibuprofentablet, film coated200 mg/1oralWal Mart Stores Inc2016-03-02Not applicableUs
Equate Ibuprofentablet, coated200 mg/1oralWal Mart Stores Inc1989-09-15Not applicableUs
Equate Ibuprofensuspension100 mg/5mLoralWal Mart Stores Inc1999-02-02Not applicableUs
Equate Ibuprofen Childrenssuspension100 mg/5mLoralWal Mart Stores Inc2010-08-19Not applicableUs
Equate Ibuprofen Childrenssuspension100 mg/5mLoralWal Mart Stores Inc2002-04-16Not applicableUs
Extra Strength Ibuprofentablet400 mgoralVita Health Products IncNot applicableNot applicableCanada
Extra Strength Ibuprofentablet400 mgoralVita Health Products Inc2002-11-222008-08-05Canada
Extra Strength Ibuprofentablet400 mgoralPharmascience Inc2010-02-01Not applicableCanada
Extra Strength Ibuprofentablet400 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Extra Strength Ibuprofen Liquid Capsulescapsule400 mgoralVita Health Products Inc2011-06-10Not applicableCanada
Extra Strength Ibuprofen Liquid Filled Capsulescapsule400 mgoralApotex Inc2009-03-16Not applicableCanada
Extra Strength Ibuprofen Liquid Gel Capsulescapsule400 mgoralApotex Inc2012-07-15Not applicableCanada
Family Wellness Childrens Ibuprofensuspension100 mg/5mLoralFamily Dollar Services Inc2002-08-22Not applicableUs
Fast Pain Relieftablet, coated200 mg/1oralWe Care Distributor Inc.2015-12-02Not applicableUs
Flex-printablet200 mg/1oralProvision Medical Products2015-03-31Not applicableUs
Formu Care Ibuprofentablet200 mg/1oralAccess Business Group LLC1991-01-15Not applicableUs
Formu Care Ibuprofen Childrenssuspension100 mg/5mLoralAccess Business Group LLC1999-01-19Not applicableUs
Fulton Street Market Ibuprofentablet, film coated200 mg/1oralAccess Business Group LLC1991-01-15Not applicableUs
Good Neighbor Pharmacy Childrens Ibuprofensuspension100 mg/5mLoralAmerisource Bergen2002-04-02Not applicableUs
Good Neighbor Pharmacy Childrens Ibuprofensuspension100 mg/5mLoralAmerisource Bergen2002-04-02Not applicableUs
Good Neighbor Pharmacy Childrens Ibuprofensuspension100 mg/5mLoralAmerisource Bergen2002-05-13Not applicableUs
Good Neighbor Pharmacy Ibuprofentablet, coated200 mg/1oralAmerisource Bergen2006-03-28Not applicableUs
Good Neighbor Pharmacy Ibuprofentablet, coated200 mg/1oralAmerisource Bergen1989-09-15Not applicableUs
Good Neighbor Pharmacy Ibuprofentablet200 mg/1oralAmerisource Bergen1990-01-15Not applicableUs
Good Neighbor Pharmacy Ibuprofensuspension100 mg/5mLoralAmerisource Bergen1999-11-22Not applicableUs
Good Neighbor Pharmacy Ibuprofensuspension/ drops50 mg/1.25mLoralAmerisource Bergen2004-10-12Not applicableUs
Good Neighbor Pharmacy Ibuprofentablet, chewable100 mg/1oralAmerisource Bergen2004-10-12Not applicableUs
Good Neighbor Pharmacy Ibuprofentablet, film coated256 mg/1oralAmerisource Bergen2016-03-21Not applicableUs
Good Neighbor Pharmacy Ibuprofentablet, film coated200 mg/1oralAmerisource Bergen2006-06-14Not applicableUs
Good Neighbor Pharmacy Ibuprofentablet100 mg/1oralAmerisource Bergen2009-10-19Not applicableUs
Good Neighbor Pharmacy Ibuprofensuspension100 mg/5mLoralAmerisource Bergen1999-01-28Not applicableUs
Good Neighbor Pharmacy Ibuprofen Childrenssuspension100 mg/5mLoralAmerisource Bergen1994-08-09Not applicableUs
Good Sense Childrens Ibuprofen Oral Suspensionsuspension100 mg/5mLoralL Perrigo Company2002-04-09Not applicableUs
Good Sense Ibuprofentablet, film coated200 mg/1oralL Perrigo Company1989-09-15Not applicableUs
Good Sense Ibuprofentablet, film coated200 mg/1oralL Perrigo Company2006-04-27Not applicableUs
Good Sense Ibuprofentablet, chewable100 mg/1oralL Perrigo Company2004-11-09Not applicableUs
Good Sense Ibuprofensuspension100 mg/5mLoralL. Perrigo Company1994-05-09Not applicableUs
Good Sense Ibuprofencapsule, liquid filled200 mg/1oralL Perrigo Company2010-01-28Not applicableUs
Good Sense Ibuprofentablet, chewable100 mg/1oralDispensing Solutions, Inc.2004-11-09Not applicableUs
Good Sense Ibuprofentablet, coated200 mg/1oralL Perrigo Company2006-03-10Not applicableUs
Good Sense Ibuprofentablet, coated200 mg/1oralL Perrigo Company1991-02-15Not applicableUs
Good Sense Ibuprofen Childrenssuspension100 mg/5mLoralL. Perrigo Company1999-01-07Not applicableUs
Good Sense Ibuprofen Childrenssuspension100 mg/5mLoralL. Perrigo Company2002-05-04Not applicableUs
Good Sense Ibuprofen Childrenssuspension100 mg/5mLoralL. Perrigo Company2002-04-09Not applicableUs
Good Sense Ibuprofen Childrenssuspension100 mg/5mLoralRebel Distributors Corp1999-01-07Not applicableUs
Good Sense Ibuprofen Infantssuspension50 mg/1.25mLoralL Perrigo Company2000-02-08Not applicableUs
Good Sense Infants Ibuprofensuspension/ drops50 mg/1.25mLoralL. Perrigo Company2016-02-05Not applicableUs
Green Guard Ibupro Relieftablet, film coated200 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Green Guard Ibupro Relieftablet, coated200 mg/1oralUnifirst First Aid Corporation2016-02-01Not applicableUs
Green Guard Ibuprofen Relieftablet, coated200 mg/1oralUnifirst First Aid2014-11-17Not applicableUs
Harmon Face Values Ibuprofensuspension100 mg/5mLoralHarmon Stores Inc.2011-12-18Not applicableUs
Harris Teeter Childrens Ibuprofensuspension100 mg/5mLoralHarris Teeter, LLC2015-11-21Not applicableUs
Harris Teeter Childrens Ibuprofensuspension100 mg/5mLoralHarris Teeter, LLC2015-11-21Not applicableUs
Harris Teeter Ibuprofensuspension/ drops50 mg/1.25mLoralHarris Teeter, LLC2015-11-05Not applicableUs
Harris Teeter Ibuprofen Infantssuspension50 mg/1.25mLoralHarris Teeter, LLC2015-11-21Not applicableUs
Health Mart Childrens Ibuprofensuspension100 mg/5mLoralMc Kesson2011-11-29Not applicableUs
Health Mart Childrens Ibuprofensuspension100 mg/5mLoralMc Kesson2013-08-13Not applicableUs
Health Mart Ibuprofensuspension/ drops50 mg/1.25mLoralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofentablet, coated200 mg/1oralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofentablet, film coated200 mg/1oralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofentablet, coated200 mg/1oralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofensuspension50 mg/1.25mLoralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofensuspension100 mg/5mLoralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofensuspension100 mg/5mLoralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofen Ibtablet, coated200 mg/1oralMc Kesson2011-11-21Not applicableUs
Health Mart Ibuprofen Ibtablet, film coated200 mg/1oralMc Kesson2013-10-26Not applicableUs
Health Sense Infants Ibuprofen Oral Suspensionsuspension50 mg/1.25mLoralDolgencorp Inc2009-06-08Not applicableUs
Health Sense Proviltablet, film coated200 mg/1oralPrime Marketing, LLC2006-01-01Not applicableUs
Healthy Accents Ibuprofentablet, film coated200 mg/1oralDZA Brands LLC2013-05-22Not applicableUs
Healthy Accents Ibuprofensuspension/ drops50 mg/1.25mLoralDZA Brands LLC2011-06-06Not applicableUs
Healthy Accents Ibuprofensuspension100 mg/5mLoralDZA Brands LLC2008-03-03Not applicableUs
Healthy Accents Ibuprofentablet, coated200 mg/1oralDZA Brands LLC2008-05-17Not applicableUs
Healthy Accents Ibuprofentablet, film coated200 mg/1oralDZA Brands LLC2008-01-22Not applicableUs
Healthy Accents Ibuprofentablet, film coated200 mg/1oralDZA Brands LLC2009-03-20Not applicableUs
Healthy Accents Ibuprofentablet, chewable100 mg/1oralDZA Brands LLC2011-06-30Not applicableUs
Healthy Accents Ibuprofen Childrenssuspension100 mg/5mLoralDZA Brands LLC2008-03-03Not applicableUs
Healthy Accents Ibuprofen Infantssuspension50 mg/1.25mLoralDZA Brands LLC2008-02-18Not applicableUs
Help I Have An Aching Bodytablet200 mg/1oralHelp Remedies, Inc.2009-07-01Not applicableUs
Henry Schein Ibuprofentablet, film coated200 mg/1oralHenry Schein Inc.2008-12-30Not applicableUs
Henry Schein Ibuprofentablet, film coated200 mg/1oralHenry Schein Inc.2015-12-15Not applicableUs
Ibuprofensuspension100 mg/5mLoralHy Vee Inc1997-09-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralL.N.K. International, Inc.1999-03-02Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralLIVE BETTER (The Great Atlantic & Pacific Tea Company)2013-03-25Not applicableUs
Ibuprofentablet200 mg/1oralWestern Family Foods, Inc.2012-07-05Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2010-07-07Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralPublix Supermarkets, Inc.2013-04-30Not applicableUs
Ibuprofentablet, coated200 mg/1oralShasun Pharmaceuticals Limited2011-04-28Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralCVS Pharmacy2014-07-31Not applicableUs
Ibuprofensuspension100 mg/5mLoralCVS Pharmacy2009-06-30Not applicableUs
Ibuprofentablet, coated200 mg/1oralREMEDYREPACK INC.2015-03-07Not applicableUs
Ibuprofentablet200 mg/1oralGranules India Limited2011-01-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralHarmon Stores2014-08-31Not applicableUs
Ibuprofentablet, film coated200 mg/1oralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralContract Pharmacy Services Pa2010-08-02Not applicableUs
Ibuprofencapsule, liquid filled220 mg/1oralSPIRIT PHARMACEUTICALS,LLC2012-05-01Not applicableUs
Ibuprofentablet200 mg/1oralMARKSANS PHARMA LIMITED2012-07-042015-12-29Us
Ibuprofentablet200 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-12-16Not applicableUs
Ibuprofentablet, coated200 mg/1oralWeeks & Leo Co., Inc.2013-05-17Not applicableUs
Ibuprofentablet200 mg/1oralApotheca Inc.2009-09-16Not applicableUs
Ibuprofentablet200 mg/1oralBetter Living Brands, Llc1988-05-24Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralKroger Company2010-05-15Not applicableUs
Ibuprofentablet, film coated200 mg/1oralH E B1989-02-15Not applicableUs
Ibuprofentablet, film coated200 mg/1oralSUPERVALU INC.2002-03-30Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralCare One (American Sales Company)2013-03-15Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralHy Vee2013-04-13Not applicableUs
Ibuprofentablet, film coated200 mg/1oralFRED'S, INC.2002-04-08Not applicableUs
Ibuprofentablet200 mg/1oralMedline Industries, Inc.2014-09-08Not applicableUs
Ibuprofentablet, coated200 mg/1oralWestern Family Foods, Inc.2013-11-30Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralHealthy Accents (DZA Brands, LLC)2012-12-11Not applicableUs
Ibuprofentablet, coated200 mg/1oralFamily Dollar (FAMILY WELLNESS)2014-06-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralDolgencorp, LLC1988-05-24Not applicableUs
Ibuprofentablet, coated200 mg/1oralShasun Pharmaceuticals Limited2011-03-28Not applicableUs
Ibuprofensuspension100 mg/5mLoralCVS Pharmacy2002-08-27Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralValu Merchandisers Company (Best Choice)2012-06-19Not applicableUs
Ibuprofentablet, film coated200 mg/1oralTYA Pharmaceuticals1988-05-24Not applicableUs
Ibuprofentablet, coated200 mg/1oralWin Co Foods, Llc2014-12-15Not applicableUs
Ibuprofentablet, film coated200 mg/1oralChain Drug Consortium LLC2013-05-07Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralBJWC2012-09-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralHarris Teeter, LLC2015-02-28Not applicableUs
Ibuprofensuspension50 mg/1.25mLoralMajor Pharmaceuticals2000-01-08Not applicableUs
Ibuprofentablet, chewable100 mg/1oralRite Aid Corporation2004-05-06Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralSelect Brand Dist.2010-03-13Not applicableUs
Ibuprofentablet, film coated200 mg/1oralBetter Living Brands, Llc2002-03-30Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralThe Kroger Co.2015-01-31Not applicableUs
Ibuprofentablet, film coated200 mg/1oralKroger Company2015-08-28Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralMEIJER, INC.2015-02-28Not applicableUs
Ibuprofentablet, film coated200 mg/1oralMeijer1988-05-24Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralHy Vee2013-01-15Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralEQUATE (Walmart Stores, Inc.)2015-02-28Not applicableUs
Ibuprofentablet400 mgoralD.C. Labs Limited2003-09-222005-07-19Canada
Ibuprofentablet, film coated200 mg/1oralL&R Distributors, Inc.1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralH E B1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralContract Pharmacal Corp.2014-01-15Not applicableUs
Ibuprofentablet, coated200 mg/1oralGood Sense (Geiss, Destin & Dunn, Inc.)2013-04-13Not applicableUs
Ibuprofentablet, coated200 mg/1oralPolygen Pharmaceuticals LLC2012-06-05Not applicableUs
Ibuprofentablet200 mg/1oralDiscount Drug Mart2013-06-20Not applicableUs
Ibuprofentablet200 mg/1oralSalado Sales, Inc.1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralKinray2011-11-22Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralMc Kesson (Health Mart)2012-04-09Not applicableUs
Ibuprofentablet, coated200 mg/1oralAvema Pharma Solutions2013-08-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralCostco Wholesale2010-07-08Not applicableUs
Ibuprofentablet200 mg/1oralChain Drug Consortium2014-11-04Not applicableUs
Ibuprofentablet, film coated200 mg/1oralPreferred Pharmaceuticals, Inc.2014-01-02Not applicableUs
Ibuprofentablet, film coated200 mg/1oralPharbest Pharmaceuticals, Inc.2011-01-18Not applicableUs
Ibuprofentablet, coated200 mg/1oralSafeway1997-07-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWALGREEN CO.1988-05-24Not applicableUs
Ibuprofensuspension100 mg/5mLoralKroger Company2002-11-20Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralSuper Valu (Equaline)2010-08-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralHannaford Brothers Company1995-06-29Not applicableUs
Ibuprofentablet, coated200 mg/1oralHy Vee Inc1989-07-15Not applicableUs
Ibuprofentablet200 mg/1oralEQUATE (Walmart Stores, Inc.)2015-05-04Not applicableUs
Ibuprofentablet, chewable100 mg/1oralWalgreen Company2009-05-05Not applicableUs
Ibuprofentablet200 mg/1oralThe Kroger Co.2014-02-28Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralShopko Stores Operating Co., LLC.2010-07-09Not applicableUs
Ibuprofentablet, film coated200 mg/1oralSUPERVALU INC.1988-05-24Not applicableUs
Ibuprofentablet200 mgoralVita Health Products IncNot applicableNot applicableCanada
Ibuprofentablet, film coated200 mg/1oralL.N.K. International, Inc.1999-03-02Not applicableUs
Ibuprofensuspension100 mg/5mLoralPhysicians Total Care, Inc.2000-09-12Not applicableUs
Ibuprofentablet200 mg/1oralWestern Family Foods, Inc.2011-12-15Not applicableUs
Ibuprofentablet, coated200 mg/1oralFamily Dollar (FAMILY WELLNESS)2015-05-04Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2012-05-17Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralPublix Supermarkets, Inc.2012-07-03Not applicableUs
Ibuprofentablet, coated200 mg/1oralShasun Pharmaceuticals Limited2011-04-04Not applicableUs
Ibuprofentablet, coated200 mg/1oralCVS Pharmacy2006-02-17Not applicableUs
Ibuprofentablet200 mg/1oralGranules India Limited2011-01-01Not applicableUs
Ibuprofentablet, coated200 mg/1oralChain Drug Marketing Association2012-08-27Not applicableUs
Ibuprofentablet200 mg/1oralContract Pharmacy Services Pa2010-08-16Not applicableUs
Ibuprofentablet200 mg/1oralMARKSANS PHARMA LIMITED2012-07-042015-12-29Us
Ibuprofencapsule, liquid filled200 mg/1oralSafeway, Inc.2010-07-06Not applicableUs
Ibuprofentablet200 mg/1oralMARKSANS PHARMA LIMITED2015-11-06Not applicableUs
Ibuprofentablet, film coated200 mg/1oralHarmon Store Inc.2002-03-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralFRED'S, INC.1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralContract Pharmacal Corp.2014-01-15Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralGood Sense (Geiss, Destin & Dunn, Inc.)2013-04-23Not applicableUs
Ibuprofentablet, coated200 mg/1oralPolygen Pharmaceuticals LLC2012-06-05Not applicableUs
Ibuprofentablet, film coated200 mg/1oralArmy and Air Force Exchange Service2002-04-08Not applicableUs
Ibuprofentablet, coated200 mg/1oralWestern Family Foods Inc2001-09-05Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralPL Developments2012-05-17Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2002-03-30Not applicableUs
Ibuprofentablet, coated200 mg/1oralAvema Pharma Solutions2013-08-01Not applicableUs
Ibuprofentablet200 mg/1oralSDA Laboratories, Inc.2011-01-27Not applicableUs
Ibuprofentablet200 mg/1oralChain Drug Consortium1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralMajor Pharmaceuticals1988-05-24Not applicableUs
Ibuprofentablet, coated200 mg/1oralTarget Corporation2014-03-28Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWALGREEN CO.1988-05-24Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralThe Kroger Co.2012-07-12Not applicableUs
Ibuprofensuspension100 mg/5mLoralKroger Company2011-04-25Not applicableUs
Ibuprofentablet, chewable100 mg/1oralHannaford Brothers Company2004-06-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralHy Vee Inc1991-03-15Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralRugby Laboratories, Inc.2012-03-26Not applicableUs
Ibuprofentablet, chewable100 mg/1oralWalgreen Company2013-12-09Not applicableUs
Ibuprofentablet, coated200 mg/1oralThe Kroger Co.2015-06-30Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralTOP CARE (Topco Associates LLC)2015-05-31Not applicableUs
Ibuprofentablet, coated200 mg/1oralShopko Stores Operating Co., LLC2013-08-19Not applicableUs
Ibuprofensuspension100 mg/5mLoralPerrigo New York Inc2011-11-17Not applicableUs
Ibuprofentablet400 mgoralPerrigo InternationalNot applicableNot applicableCanada
Ibuprofentablet, film coated200 mg/1oralCardinal Health1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralTime Cap Laboratories,Inc2016-03-22Not applicableUs
Ibuprofentablet200 mg/1oralHART Health1987-06-03Not applicableUs
Ibuprofentablet, film coated200 mg/1oralL.N.K. International, Inc.1999-03-02Not applicableUs
Ibuprofensuspension100 mg/5mLoralH.J. Harkins Company, Inc.1999-02-07Not applicableUs
Ibuprofentablet200 mg/1oralPhysicians Total Care, Inc.2007-10-16Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralWestern Family Foods, Inc.2014-09-30Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralFreds Inc2013-04-13Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralPublix Supermarkets, Inc.2012-07-03Not applicableUs
Ibuprofentablet, film coated200 mg/1oralGeri Care Pharmaceutical Corp2004-01-01Not applicableUs
Ibuprofentablet, chewable100 mg/1oralCVS Pharmacy2004-05-07Not applicableUs
Ibuprofentablet, coated200 mg/1oralCVS Pharmacy2001-07-31Not applicableUs
Ibuprofentablet200 mg/1oralKinray2011-07-25Not applicableUs
Ibuprofentablet, film coated200 mg/1oralChain Drug Marketing Association Inc1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralSam's West Inc1988-05-24Not applicableUs
Ibuprofentablet, coated200 mg/1oralVelocity Pharma2012-07-01Not applicableUs
Ibuprofentablet, film coated200 mg/1oralBetter Living Brands, Llc1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralMARKSANS PHARMA LIMITED2015-11-06Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralWalgreen Company2005-05-13Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralThe Kroger Co.2012-07-12Not applicableUs
Ibuprofentablet, coated200 mg/1oralTOP CARE (Topco Associates LLC)2014-04-30Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralMeijer Distribution Inc2004-04-18Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralHannaford Brothers Company2005-03-16Not applicableUs
Ibuprofentablet, coated200 mg/1oralRugby Laboratories Inc2011-03-01Not applicableUs
Ibuprofentablet400 mgoral1466406 Ontario LtdNot applicableNot applicableCanada
Ibuprofentablet, film coated200 mg/1oralHarmon Store Inc.1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralFRED'S, INC.1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralContract Pharmacal Corp.2015-10-01Not applicableUs
Ibuprofentablet, film coated200 mg/1oralCentral Texas Community Health Centers2003-06-24Not applicableUs
Ibuprofentablet, coated200 mg/1oralMedicine Shoppe International Inc1990-02-15Not applicableUs
Ibuprofentablet200 mg/1oralGeiss, Destin & Dunn, Inc (Goodsense)2011-12-22Not applicableUs
Ibuprofentablet200 mg/1oralGenuine First Aid LLC2010-02-17Not applicableUs
Ibuprofentablet, film coated200 mg/1oralArmy and Air Force Exchange Service2002-03-30Not applicableUs
Ibuprofentablet200 mg/1oralWestern Family Foods Inc2001-09-05Not applicableUs
Ibuprofentablet, coated200 mg/1oralHealthy Accents (DZA Brands, LLC)2013-12-30Not applicableUs
Ibuprofentablet, coated200 mg/1oralPublix Super Markets Inc1988-09-15Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralCVS Pharmacy2004-05-07Not applicableUs
Ibuprofentablet, coated200 mg/1oralAvema Pharma Solutions2013-08-01Not applicableUs
Ibuprofentablet, film coated200 mg/1oralChain Drug Marketing Association Inc1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralRaining Rose Inc.2015-08-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralWin Co Foods, Llc2014-12-31Not applicableUs
Ibuprofentablet, film coated200 mg/1oralChain Drug Consortium2002-03-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralMajor Pharmaceuticals2007-11-06Not applicableUs
Ibuprofentablet, coated200 mg/1oralTarget Corporation2013-11-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralRite Aid1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralStephen L. La France Pharmacy, Inc.2002-04-08Not applicableUs
Ibuprofentablet, film coated200 mg/1oralSafeway1997-08-14Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralThe Kroger Co.2010-07-01Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralH E B2005-02-25Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralEqualine (Super Valu)2012-01-10Not applicableUs
Ibuprofentablet, coated200 mg/1oralMeijer Distribution Inc1988-11-15Not applicableUs
Ibuprofentablet, film coated200 mg/1oralRebel Distributors Corp2004-01-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralMcKesson (Sunmark)2010-07-09Not applicableUs
Ibuprofentablet200 mg/1oralSDA Laboratories, Inc.2016-03-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2016-02-29Not applicableUs
Ibuprofentablet200 mg/1oralL.N.K. International, Inc.1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralL.N.K. International, Inc.1999-03-02Not applicableUs
Ibuprofentablet, film coated200 mg/1oralH.J. Harkins Company, Inc.1988-05-24Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralWestern Family Foods, Inc.2010-03-13Not applicableUs
Ibuprofentablet, coated200 mg/1oralPublix Super Markets Inc2006-03-22Not applicableUs
Ibuprofentablet, coated200 mg/1oralAAA Pharmaceutical, Inc.2012-12-04Not applicableUs
Ibuprofentablet, coated200 mg/1oralP And L Development Of New York Corporation (Ready In Case)2014-02-28Not applicableUs
Ibuprofentablet200 mg/1oralCVS Pharmacy2001-07-10Not applicableUs
Ibuprofentablet200 mg/1oralKinray2011-07-25Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralSam's West, Inc2015-05-31Not applicableUs
Ibuprofencapsule, coated200 mg/1oralNash Finch Company2002-04-08Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralMARKSANS PHARMA LIMITED2011-05-09Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralWalgreens2013-09-30Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralThe Kroger Co2012-05-11Not applicableUs
Ibuprofentablet, coated200 mg/1oralKroger Company1990-10-15Not applicableUs
Ibuprofentablet200 mg/1oralTOP CARE (Topco Associates LLC)2014-02-28Not applicableUs
Ibuprofentablet, coated200 mg/1oralShopko Stores Operating Co., LLC2013-09-12Not applicableUs
Ibuprofentablet200 mg/1oralH E B1988-05-24Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralMEIJER, INC.2010-07-12Not applicableUs
Ibuprofentablet, coated200 mg/1oralHannaford Brothers Company2006-05-31Not applicableUs
Ibuprofentablet, chewable100 mg/1oralHy Vee Inc2005-02-12Not applicableUs
Ibuprofentablet, film coated200 mg/1oralRugby Laboratories1988-05-24Not applicableUs
Ibuprofentablet200 mgoralPharmascience Inc2010-03-05Not applicableCanada
Ibuprofentablet, film coated200 mg/1oralA S Medication Solutions2011-01-18Not applicableUs
Ibuprofentablet, film coated200 mg/1oralMedicine Shoppe International Inc1988-03-15Not applicableUs
Ibuprofentablet200 mg/1oralNew World Imports2010-09-10Not applicableUs
Ibuprofentablet, film coated200 mg/1oralArmy and Air Force Exchange Service1988-05-24Not applicableUs
Ibuprofentablet, chewable100 mg/1oralWestern Family Foods Inc2009-04-07Not applicableUs
Ibuprofentablet, coated200 mg/1oralHealthy Accents (DZA Brands, LLC)2015-05-04Not applicableUs
Ibuprofentablet, film coated200 mg/1oralPublix Super Markets Inc1988-09-15Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralP And L Development Of New York Corporation (Ready In Case)2014-07-31Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralProficient Rx LP1988-05-24Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralQUALITY CHOICE (Chain Drug Marketing Association)2013-03-11Not applicableUs
Ibuprofentablet200 mg/1oralChain Drug Consortium1988-05-24Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralOUR FAMILY (Nash Finch Company)2013-04-30Not applicableUs
Ibuprofentablet, coated200 mg/1oralMajor Pharmaceuticals1994-08-16Not applicableUs
Ibuprofentablet200 mg/1oralTarget Corporation2011-09-14Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralRite Aid Corporation2005-06-03Not applicableUs
Ibuprofentablet, film coated200 mg/1oralL&R Distributors, Inc.2002-03-30Not applicableUs
Ibuprofentablet200 mg/1oralThe Kroger Co.2015-06-30Not applicableUs
Ibuprofentablet200 mg/1oralMeijer Distribution Inc1988-02-15Not applicableUs
Ibuprofensuspension100 mg/5mLoralHannaford Brothers Company1999-02-04Not applicableUs
Ibuprofentablet200 mg/1oralRebel Distributors Corp2011-01-27Not applicableUs
Ibuprofensuspension50 mg/1.25mLoralPerrigo New York Inc2014-04-09Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWal Mart Stores Inc2002-04-08Not applicableUs
Ibuprofentablet, film coated200 mg/1oralFamily Dollar1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralKinray, Inc.2016-03-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralSMART SENSE (Kmart)2012-09-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralL.N.K. International, Inc.1999-03-02Not applicableUs
Ibuprofentablet200 mg/1oralWestern Family Foods, Inc.2011-02-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralFreds Inc2012-07-02Not applicableUs
Ibuprofentablet, coated200 mg/1oralAAA Pharmaceutical, Inc.2012-12-04Not applicableUs
Ibuprofentablet, chewable100 mg/1oralCVS Pharmacy1991-11-05Not applicableUs
Ibuprofentablet, film coated200 mg/1oralNash Finch Company2002-03-30Not applicableUs
Ibuprofensuspension100 mg/5mLoralRite Aid Corporation2002-05-10Not applicableUs
Ibuprofentablet200 mg/1oralMARKSANS PHARMA LIMITED2011-07-25Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralWalgreens2014-08-31Not applicableUs
Ibuprofentablet, coated200 mg/1oralKroger Company2006-03-11Not applicableUs
Ibuprofentablet200 mg/1oralKroger Company1988-01-15Not applicableUs
Ibuprofentablet, coated200 mg/1oralTOP CARE (Topco Associates LLC)2013-04-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralShopko Stores Operating Co., LLC2013-09-09Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralCardinal Health (Leader)2012-12-11Not applicableUs
Ibuprofentablet, coated200 mg/1oralMeijer Distribution Inc2006-06-21Not applicableUs
Ibuprofentablet, film coated200 mg/1oralMeijer Distribution Inc1993-04-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralHy Vee2015-01-31Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWal Mart Stores Inc1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralRugby Laboratories1988-05-24Not applicableUs
Ibuprofentablet200 mgoralPharmascience Inc2010-03-05Not applicableCanada
Ibuprofentablet200 mgoralD.C. Labs Limited2000-10-112005-07-19Canada
Ibuprofentablet400 mgoralApotex IncNot applicableNot applicableCanada
Ibuprofensuspension100 mg/5mLoralH E B2016-03-01Not applicableUs
Ibuprofentablet, film coated200 mg/1oralTime Cap Laboratories,Inc2012-04-16Not applicableUs
Ibuprofentablet200 mg/1oralNew World Imports2012-06-05Not applicableUs
Ibuprofentablet200 mg/1oralArmy and Air Force Exchange Service1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWestern Family Foods Inc2006-05-31Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralHealthy Accents (DZA Brands, LLC)2013-04-15Not applicableUs
Ibuprofentablet, film coated200 mg/1oralPublix Super Markets Inc2006-05-03Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralJ.P BUSINESS ENTERPRISE2013-08-20Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED1988-05-24Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralBest Choice (Valu Merchandisers Company)2010-08-21Not applicableUs
Ibuprofentablet200 mg/1oralChain Drug Consortium2002-04-08Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralTarget Corporation2010-08-01Not applicableUs
Ibuprofentablet, film coated200 mg/1oralSafeway2012-08-09Not applicableUs
Ibuprofentablet, film coated200 mg/1oralFamily Dollar1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralKinray, Inc.2016-03-01Not applicableUs
Ibuprofentablet, film coated200 mg/1oralGreenbrier International, Inc.1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-02-16Not applicableUs
Ibuprofentablet, film coated200 mg/1oralL.N.K. International, Inc.1999-03-02Not applicableUs
Ibuprofensuspension100 mg/5mLoralWestern Family Foods Inc1999-01-28Not applicableUs
Ibuprofentablet, coated200 mg/1oralDolgencorp, Inc. (DOLLAR GENERAL & REXALL)2015-05-31Not applicableUs
Ibuprofentablet, film coated200 mg/1oralDolgencorp, LLC2002-03-30Not applicableUs
Ibuprofentablet, coated200 mg/1oralAAA Pharmaceutical, Inc.2012-12-04Not applicableUs
Ibuprofentablet, coated200 mg/1oralP & L Development, LLC2014-11-30Not applicableUs
Ibuprofentablet, film coated200 mg/1oralCVS Pharmacy2006-04-27Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralPreferred Plus (Kinray)2010-08-30Not applicableUs
Ibuprofentablet, sugar coated200 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2005-01-10Not applicableUs
Ibuprofentablet, film coated200 mg/1oralCostco Wholesale Corporation1999-03-02Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralChain Drug Consortium, LLC2010-07-08Not applicableUs
Ibuprofencapsule, coated200 mg/1oralNash Finch Company1988-05-24Not applicableUs
Ibuprofentablet, chewable100 mg/1oralRite Aid Corporation2010-06-25Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralSafeway2005-07-11Not applicableUs
Ibuprofentablet200 mg/1oralMARKSANS PHARMA LIMITED2011-07-25Not applicableUs
Ibuprofentablet, film coated200 mg/1oralKroger Company1993-02-28Not applicableUs
Ibuprofentablet, film coated200 mg/1oralGreenbrier International, Inc.2002-04-08Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralSuper Valu (Equaline)2010-07-09Not applicableUs
Ibuprofentablet100 mg/1oralMeijer Distribution Inc2009-05-27Not applicableUs
Ibuprofensuspension100 mg/5mLoralHy Vee Inc1999-03-05Not applicableUs
Ibuprofentablet, coated200 mg/1oralEQUATE (Walmart Stores, Inc.)2013-12-30Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralWalgreen Company2011-05-09Not applicableUs
Ibuprofentablet200 mgoralVita Health Products Inc1998-10-062008-08-05Canada
Ibuprofentablet400 mgoralPharmascience IncNot applicableNot applicableCanada
Ibuprofencapsule, liquid filled200 mg/1oralTIME CAP LABORATORIES, INC2015-12-23Not applicableUs
Ibuprofentablet200 mgoralApotex Inc2015-12-23Not applicableCanada
Ibuprofentablet200 mg/1oralL.N.K. International, Inc.2002-04-08Not applicableUs
Ibuprofentablet200 mg/1oralMedline Industries2013-01-15Not applicableUs
Ibuprofentablet200 mg/1oralCardinal Health2011-06-03Not applicableUs
Ibuprofentablet, coated200 mg/1oralWestern Family Foods, Inc.2011-09-01Not applicableUs
Ibuprofentablet200 mg/1oralFamily Dollar (FAMILY WELLNESS)2015-05-04Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralPublix Super Markets Inc2011-09-09Not applicableUs
Ibuprofentablet, coated200 mg/1oralShasun Pharmaceuticals Limited2011-04-04Not applicableUs
Ibuprofentablet, coated200 mg/1oralCVS Pharmacy2015-10-07Not applicableUs
Ibuprofentablet, film coated200 mg/1oralDIRECT RX2014-01-01Not applicableUs
Ibuprofencapsule, coated200 mg/1oralGREAT LAKES WHOLESALE, MARKETING, & SALES, INC.1988-05-24Not applicableUs
Ibuprofentablet, film coated200 1/1oralAdvanced First Aid, Inc.2015-04-09Not applicableUs
Ibuprofensuspension100 mg/5mLoralMajor Pharmaceuticals1999-02-07Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralTarget Corporation2015-02-28Not applicableUs
Ibuprofentablet, film coated200 mg/1oralL&R Distributors, Inc.1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWalgreen Company2009-01-21Not applicableUs
Ibuprofentablet, chewable100 mg/1oralKroger Company2004-05-10Not applicableUs
Ibuprofentablet, film coated200 mg/1oralShopko Stores Operating Co., LLC2013-09-09Not applicableUs
Ibuprofentablet, coated200 mg/1oralH E B1991-08-09Not applicableUs
Ibuprofentablet200 mg/1oralSUPERVALU INC.2002-04-08Not applicableUs
Ibuprofentablet, film coated200 mg/1oralKroger Company2006-04-27Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralTOP CARE (Topco Associates LLC)2013-04-30Not applicableUs
Ibuprofentablet, chewable100 mg/1oralShopko Stores Operating Co., LLC2013-08-06Not applicableUs
Ibuprofentablet, film coated200 mg/1oralH E B2006-07-04Not applicableUs
Ibuprofentablet, film coated200 mg/1oralMeijer2002-04-08Not applicableUs
Ibuprofensuspension/ drops50 mg/1.25mLoralHy Vee Inc2005-02-26Not applicableUs
Ibuprofentablet, film coated200 mg/1oralSave A Lot Food Stores, Ltd.1988-05-24Not applicableUs
Ibuprofenliquid100 mg/5mLoralWalgreen Company2008-07-24Not applicableUs
Ibuprofentablet300 mgoralApotex IncNot applicableNot applicableCanada
Ibuprofentablet, film coated256 mg/1oralMeijer Distribution Inc2016-03-23Not applicableUs
Ibuprofentablet200 mg/1oralMedline Industries, Inc.2015-04-21Not applicableUs
Ibuprofentablet, chewable100 mg/1oralWestern Family Foods Inc2004-09-24Not applicableUs
Ibuprofentablet, coated200 mg/1oralFamily Dollar (FAMILY WELLNESS)2014-07-31Not applicableUs
Ibuprofentablet, film coated200 mg/1oralDolgencorp, LLC1999-03-02Not applicableUs
Ibuprofentablet, chewable100 mg/1oralPublix Super Markets Inc2004-10-28Not applicableUs
Ibuprofentablet, film coated200 mg/1oralClinical Solutions Wholesale1988-05-24Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralCVS Pharmacy2012-09-24Not applicableUs
Ibuprofentablet200 mg/1oralProficient Rx LP2011-01-27Not applicableUs
Ibuprofentablet, coated200 mg/1oralWin Co Foods, Llc2014-12-15Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralChain Drug Consortium, LLC2014-12-31Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralBJWC (Berkley & Jensen / BJ's)2013-05-15Not applicableUs
Ibuprofensuspension50 mg/1.25mLoralRite Aid Corporation2004-05-06Not applicableUs
Ibuprofentablet, film coated200 mg/1oralBetter Living Brands, Llc2002-04-08Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralWalgreens2016-01-27Not applicableUs
Ibuprofentablet, film coated200 mg/1oralH E B2002-04-08Not applicableUs
Ibuprofentablet, film coated200 mg/1oralA S Medication Solutions2011-01-18Not applicableUs
Ibuprofentablet, film coated200 mg/1oralL.N.K. International, Inc.1999-03-02Not applicableUs
Ibuprofentablet200 mg/1oralPolygen Pharmaceuticals LLC2013-07-02Not applicableUs
Ibuprofentablet200 mg/1oralWestern Family Foods, Inc.2011-02-01Not applicableUs
Ibuprofentablet, coated200 mg/1oralAAA Pharmaceutical, Inc.2012-12-04Not applicableUs
Ibuprofentablet200 mg/1oralP & L Development, LLC2015-11-30Not applicableUs
Ibuprofentablet, coated200 mg/1oralAvema Pharma Solutions2013-08-01Not applicableUs
Ibuprofentablet, film coated200 mg/1oralCostco Wholesale Corporation1988-05-24Not applicableUs
Ibuprofentablet200 mg/1oralNash Finch Company1988-05-24Not applicableUs
Ibuprofentablet, film coated200 mg/1oralRite Aid2002-04-08Not applicableUs
Ibuprofensuspension100 mg/5mLoralAtlantic Biologicals Corps1999-02-07Not applicableUs
Ibuprofentablet, film coated200 mg/1oralWALGREEN CO.2002-03-30Not applicableUs
Ibuprofentablet200 mg/1oralThe Kroger Co.2011-02-02Not applicableUs
Ibuprofentablet, film coated200 mg/1oralAidarex Pharmaceuticals LLC1994-08-16Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralCardinal Health2012-04-09Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralH E B2013-01-08Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralSuper Valu (Equaline)2010-07-08Not applicableUs
Ibuprofentablet, film coated200 mg/1oralMeijer Distribution Inc2006-04-26Not applicableUs
Ibuprofentablet, coated200 mg/1oralHannaford Brothers Company1995-06-01Not applicableUs
Ibuprofencapsule, liquid filled200 mg/1oralEQUATE (Walmart Stores, Inc.)2012-12-11Not applicableUs
Ibuprofen - Tab 200mgtablet200 mgoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1998-02-052002-07-31Canada
Ibuprofen (nsaid) Pain Releiver/ Fever Reducertablet200 mg/1oralRebel Distributors Corp2009-12-16Not applicableUs
Ibuprofen (nsaid) Pain Releiver/ Fever Reducertablet200 mg/1oralAmneal Pharmaceuticals2009-12-16Not applicableUs
Ibuprofen (nsaid) Pain Releiver/ Fever Reducertablet200 mg/1oralAmneal Pharmaceuticals2009-12-16Not applicableUs
Ibuprofen 200tablet, coated200 mg/1oralWALGREEN CO.2002-04-08Not applicableUs
Ibuprofen 200 mgtablet200 mgoralPharmetics (2011) Inc2005-10-12Not applicableCanada
Ibuprofen 200 mgtablet200 mgoralPendopharm Division Of De Pharmascience Inc2007-06-012013-05-31Canada
Ibuprofen Capletcapsule200 mg/1oralChain Drug Consortium2014-11-04Not applicableUs
Ibuprofen Capletstablet200 mgoralApotex Inc2016-02-26Not applicableCanada
Ibuprofen Capletstablet200 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ibuprofen Capletstablet400 mgoralPharmetics (2011) Inc2009-01-28Not applicableCanada
Ibuprofen Capletstablet400 mgoralApotex Inc2015-12-23Not applicableCanada
Ibuprofen Capletstablet200 mgoralVita Health Products Inc2016-07-04Not applicableCanada
Ibuprofen Caplets 200 mgtablet200 mgoralVita Health Products Inc2006-04-07Not applicableCanada
Ibuprofen Caplets 200 mgtablet200 mgoralPerrigo InternationalNot applicableNot applicableCanada
Ibuprofen Capsules, 200mgcapsule200 mgoralBanner Life Sciences LlcNot applicableNot applicableCanada
Ibuprofen Capsules, 400mgcapsule400 mgoralBanner Life Sciences Llc2010-11-05Not applicableCanada
Ibuprofen Childrenssuspension100 mg/5mLoralMeijer Distribution Inc1999-01-05Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralWalgreen Company2002-03-25Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralWalgreen Company2015-06-16Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralWestern Family Foods Inc2002-10-14Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralKroger Company1999-01-19Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralCVS Pharmacy2002-09-04Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralMedicine Shoppe International Inc1999-01-09Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralH E B2002-06-10Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralMeijer Distribution Inc2002-03-19Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralKroger Company2002-11-20Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralRite Aid Corporation1999-01-08Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralSafeway1999-01-18Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralWalgreen Company1999-03-11Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralMajor Pharmaceuticals2002-04-03Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralWalgreen Company2002-03-04Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralHannaford Brothers Company2009-05-06Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralHy Vee Inc2002-05-13Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralCVS Pharmacy1999-01-07Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralPreferred Pharmaceuticals, Inc2012-04-23Not applicableUs
Ibuprofen Childrenssuspension100 mg/5mLoralHy Vee Inc2002-04-01Not applicableUs
Ibuprofen Daytimecapsule200 mgoralVita Health Products IncNot applicableNot applicableCanada
Ibuprofen Dye Freetablet, film coated200 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2004-03-11Not applicableUs
Ibuprofen Dye-freetablet, film coated200 mg/1oralWal Mart Stores Inc2004-03-11Not applicableUs
Ibuprofen Extra Strength Capletstablet400 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ibuprofen Extra Strength Capletstablet400 mgoralVita Health Products Inc2011-08-05Not applicableCanada
Ibuprofen Fast Relief Medicine for Paintablet200 mg/1oralAllegiant Health2014-12-19Not applicableUs
Ibuprofen Ibtablet, coated200 mg/1oralWOONSOCKET PRESCRIPTION CENTER,INCORPORATED2002-04-08Not applicableUs
Ibuprofen Ibtablet, coated200 mg/1oralChain Drug Marketing Association2007-05-11Not applicableUs
Ibuprofen Ibtablet, coated200 mg/1oralHy Vee Inc2006-05-14Not applicableUs
Ibuprofen Ibtablet, film coated200 mg/1oralHy Vee Inc2006-05-21Not applicableUs
Ibuprofen Ibtablet, film coated200 mg/1oralFamily Dollar2002-04-08Not applicableUs
Ibuprofen Ibtablet, coated200 mg/1oralWin Co Foods, Llc2014-12-15Not applicableUs
Ibuprofen Ibtablet, coated200 mg/1oralChain Drug Marketing Association2014-05-14Not applicableUs
Ibuprofen Ibtablet, coated200 mg/1oralWin Co Foods, Llc2014-12-15Not applicableUs
Ibuprofen Ibtablet, coated200 mg/1oralChain Drug Marketing Association2014-05-14Not applicableUs
Ibuprofen Ibtablet, coated200 mg/1oralChain Drug Marketing Association2007-05-11Not applicableUs
Ibuprofen Immediate Releasetablet, coated200 mg/1oralDiscount Drug Mart2014-12-22Not applicableUs
Ibuprofen Immediate Releasetablet, coated200 mg/1oralDiscount Drug Mart2014-12-22Not applicableUs
Ibuprofen Infantssuspension50 mg/1.25mLoralWestern Family Foods Inc2000-08-16Not applicableUs
Ibuprofen Infantssuspension50 mg/1.25mLoralHy Vee Inc2000-09-03Not applicableUs
Ibuprofen Infantssuspension50 mg/1.25mLoralH E B2002-06-18Not applicableUs
Ibuprofen Infantssuspension50 mg/1.25mLoralKroger Company2002-11-20Not applicableUs
Ibuprofen Infantssuspension50 mg/1.25mLoralMeijer Distribution Inc2000-03-17Not applicableUs
Ibuprofen Infantssuspension50 mg/1.25mLoralWalgreen Company2001-04-13Not applicableUs
Ibuprofen Juniortablet, chewable100 mg/1oralPhysicians Total Care, Inc.2007-10-16Not applicableUs
Ibuprofen Junior Strengthtablet, chewable100 mg/1oralWalgreen Company2012-12-18Not applicableUs
Ibuprofen Junior Strengthtablet, chewable100 mg/1oralMeijer Distribution Inc2004-05-02Not applicableUs
Ibuprofen Liqui-gelscapsule, liquid filled200 mg/1oralAllegiant Health2014-12-22Not applicableUs
Ibuprofen Liquid Capsulescapsule200 mgoralVita Health Products Inc2011-03-31Not applicableCanada
Ibuprofen Liquid Filled Capsulescapsule200 mgoralApotex Inc2006-11-07Not applicableCanada
Ibuprofen Liquid Gel Capsulescapsule200 mgoralApotex IncNot applicableNot applicableCanada
Ibuprofen Menstrual Pain Relieftablet400 mgoralApotex Inc2009-03-03Not applicableCanada
Ibuprofen Muscle and Jointtablet400 mgoralPharmascience Inc2012-09-12Not applicableCanada
Ibuprofen Oral Suspension USPsuspension100 mgoralApotex IncNot applicableNot applicableCanada
Ibuprofen Pain Releiver/ Fever Reducertablet200 mg/1oralAmneal Pharmaceuticals of New York, LLC2009-12-16Not applicableUs
Ibuprofen Pain Releiver/ Fever Reducertablet200 mg/1oralAmneal Pharmaceuticals of New York, LLC2009-12-16Not applicableUs
Ibuprofen Pain Reliever/ Fever Reducertablet200 mg/1oralChain Drug Consortium2014-12-30Not applicableUs
Ibuprofen Pain Reliever/ Fever Reducersuspension100 mg/5mLoralAmneal Pharmaceuticals2011-11-12Not applicableUs
Ibuprofen Pain Reliever/fever Reducertablet200 mg/1oralAllegiant Health2014-12-22Not applicableUs
Ibuprofen Pain Reliever/fever Reducercapsule, liquid filled200 mg/1oralAmneal Pharmaceuticals of New York, LLC2011-12-23Not applicableUs
Ibuprofen Pain Reliever/fever Reducercapsule, liquid filled200 mg/1oralAmneal Pharmaceuticals2013-03-29Not applicableUs
Ibuprofen Sodiumtablet, film coated256 mg/1oralWalgreen Company2016-01-13Not applicableUs
Ibuprofen Softgelscapsule, liquid filled200 mg/1oralAmerisource Bergen Drug Corporation (Good Neighbor Pharmacy)2010-07-08Not applicableUs
Ibuprofen Tab 200mgtablet200 mgoralPro Doc Limitee1985-12-312010-07-13Canada
Ibuprofen Tab 300mgtablet300 mgoralPro Doc Limitee1985-12-312010-07-13Canada
Ibuprofen Tab 400mgtablet400 mgoralPro Doc Limitee1985-12-31Not applicableCanada
Ibuprofen Tabletstablet200 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ibuprofen Tabletstablet200 mgoralVita Health Products IncNot applicableNot applicableCanada
Ibuprofen Tablets 200 mgtablet200 mgoralPerrigo InternationalNot applicableNot applicableCanada
Ibuprofen Tablets 200 mgtablet200 mgoralVita Health Products Inc2005-11-16Not applicableCanada
Ibutabtablet200 mg/1oralZee Medical Inc2012-06-12Not applicableUs
Infant's Motrin Suspension Dropssuspension40 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1998-10-14Not applicableCanada
Infants Advilsuspension/ drops50 mg/1.25mLoralPfizer Consumer Healthcare1998-01-30Not applicableUs
Infants Dye-free Ibuprofensuspension50 mg/1.25mLoralWalgreen Company2010-05-24Not applicableUs
Infants Ibuprofensuspension/ drops50 mg/1.25mLoralShopko Stores Operating Co., LLC2013-07-30Not applicableUs
Infants Ibuprofensuspension50 mg/1.25mLoralActavis Inc.2010-05-20Not applicableUs
Infants Ibuprofenliquid50 mg/1.25mLoralRite Aid2010-05-17Not applicableUs
Infants Ibuprofenliquid50 mg/1.25mLoralNash Finch Company (Our Family)2014-03-19Not applicableUs
Infants Ibuprofenliquid50 mg/1.25mLoralFred's Inc.2012-02-22Not applicableUs
Infants Ibuprofensuspension50 mg/1.25mLoralCVS Pharmacy1999-11-08Not applicableUs
Infants Ibuprofensuspension50 mg/1.25mLoralKinray, Inc.2010-07-01Not applicableUs
Infants Ibuprofensuspension50 mg/1.25mLoralFamily Dollar Services Inc.2012-02-22Not applicableUs
Infants Ibuprofensuspension50 mg/1.25mLoralChain Drug Marketing Association Inc.2009-11-01Not applicableUs
Infants Ibuprofenliquid50 mg/1.25mLoralWal Mart Stores, Inc.2012-05-21Not applicableUs
Infants Ibuprofenliquid50 mg/1.25mLoralValu Merchandisers Company2009-10-02Not applicableUs
Infants Ibuprofenliquid50 mg/1.25mLoralStephen L. La France Pharmacy, Inc.2009-10-02Not applicableUs
Infants Motrinsuspension/ drops50 mg/1.25mLoralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2004-06-01Not applicableUs
Jamp-ibuprofentablet400 mgoralJamp Pharma Corporation2014-01-07Not applicableCanada
Junior Strength Adviltablet, chewable100 mg/1oralAvera Mc Kennan Hospital2015-04-22Not applicableUs
Junior Strength Adviltablet (chewable)100 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2003-03-31Not applicableCanada
Junior Strength Adviltablet, coated100 mg/1oralPfizer Consumer Healthcare2011-06-21Not applicableUs
Junior Strength Adviltablet, chewable100 mg/1oralPfizer Consumer Healthcare2011-06-01Not applicableUs
Junior Strength Advil Fever From Colds Or Flutablet (chewable)100 mgoralPfizer Consumer Healthcare A Division Of Pfizer Canada Inc2009-11-05Not applicableCanada
Junior Strength Ibuprofentablet, chewable100 mg/1oralShopko Stores Operating Co., LLC2013-07-30Not applicableUs
Junior Strength Ibuprofentablet, chewable100 mg/1oralH E B2010-09-01Not applicableUs
Junior Strength Motrin Capletstablet100 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1999-09-202016-01-22Canada
Junior Strength Motrin Chewable Tablet 100mgtablet100 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2001-02-122003-07-15Canada
Junior Strength Motrin Chewable Tabletstablet100 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2003-05-14Not applicableCanada
Kirkland Signature Ibuprofentablet, film coated200 mg/1oralCostco Wholesale Company2003-06-25Not applicableUs
Kirkland Signature Ibuprofen Ibtablet, film coated200 mg/1oralCostco Wholesale Company2007-06-22Not applicableUs
Leader Childrens Ibuprofensuspension100 mg/5mLoralCardinal Health2002-04-25Not applicableUs
Leader Childrens Ibuprofensuspension100 mg/5mLoralCardinal Health2014-03-05Not applicableUs
Leader Childrens Ibuprofensuspension100 mg/5mLoralCardinal Health2002-05-08Not applicableUs
Leader Ibuprofentablet, film coated200 mg/1oralCardinal Health1990-10-15Not applicableUs
Leader Ibuprofentablet, coated200 mg/1oralCardinal Health2015-03-24Not applicableUs
Leader Ibuprofensuspension/ drops50 mg/1.25mLoralCardinal Health2004-07-19Not applicableUs
Leader Ibuprofensuspension100 mg/5mLoralCardinal Health2008-10-16Not applicableUs
Leader Ibuprofentablet, chewable100 mg/1oralAvera Mc Kennan Hospital2015-09-04Not applicableUs
Leader Ibuprofentablet, film coated200 mg/1oralCardinal Health2015-03-13Not applicableUs
Leader Ibuprofensuspension100 mg/5mLoralCardinal Health2002-05-08Not applicableUs
Leader Ibuprofentablet, chewable100 mg/1oralCardinal Health2004-05-28Not applicableUs
Leader Ibuprofentablet, film coated200 mg/1oralCardinal Health1990-05-15Not applicableUs
Leader Ibuprofentablet, chewable100 mg/1oralCardinal Health1990-11-15Not applicableUs
Leader Ibuprofentablet, coated200 mg/1oralCardinal Health2006-03-10Not applicableUs
Leader Ibuprofentablet, coated200 mg/1oralCardinal Health1990-05-15Not applicableUs
Leader Ibuprofensuspension100 mg/5mLoralCardinal Health1999-01-28Not applicableUs
Leader Ibuprofensuspension100 mg/5mLoralCardinal Health2002-04-25Not applicableUs
Leader Ibuprofen 200tablet200 mg/1oralCardinal Health2014-07-23Not applicableUs
Leader Ibuprofen Childrenssuspension100 mg/5mLoralCardinal Health2002-04-25Not applicableUs
Leader Ibuprofen Infantssuspension50 mg/1.25mLoralCardinal Health1999-09-30Not applicableUs
Lil Drug Store Ibuprofentablet200 mg/1oralLil' Drug Store Products, Inc.2011-01-27Not applicableUs
Lil Drug Store Ibuprofentablet200 mg/1oralLil Drug Store Products, Inc2015-01-10Not applicableUs
Major Childrens Ibuprofensuspension100 mg/5mLoralMajor Pharmaceuticals2000-02-01Not applicableUs
Medi-first Ibuprofentablet, film coated200 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Medi-first Ibuprofentablet, film coated200 mg/1oralUnifirst First Aid Corporation2016-02-01Not applicableUs
Medi-first Ibuprofentablet, coated200 mg/1oralUnifirst First Aid Corporation2014-11-17Not applicableUs
Medi-first Plus Ibuprofentablet, coated200 mg/1oralUnifirst First Aid Corporation2016-02-01Not applicableUs
Medi-first Plus Ibuprofentablet, coated200 mg/1oralUnifirst First Aid Corporation2014-11-17Not applicableUs
Medi-first Plus Ibuprofentablet, film coated200 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Medipren Tab 200mgtablet200 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1989-12-311998-08-10Canada
Medique I-printablet, film coated200 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Medique Iprintablet, coated200 mg/1oralUnifirst First Aid Corporation2016-02-01Not applicableUs
Medique Iprintablet, coated200 mg/1oralUnifirst First Aid Corporation2014-11-17Not applicableUs
Members Mark Ibuprofentablet, film coated200 mg/1oralSam's West Inc2015-05-18Not applicableUs
Midolcapsule, liquid filled200 mg/1oralBayer Health Care Llc Consumer Care2009-05-18Not applicableUs
Moore Medical Llc Ibuprofentablet, film coated200 mg/1oralMoore Medical LLC2008-12-30Not applicableUs
Moorebrand Ibuprofentablet, coated200 mg/1oralMoore Medical2014-11-172016-02-17Us
Moorebrand Ibuprofentablet, film coated200 mg/1oralMoore Medical LLC2016-02-01Not applicableUs
Motrin 200mgtablet200 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1972-12-31Not applicableCanada
Motrin 300mgtablet300 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2002-05-15Not applicableCanada
Motrin 400mgtablet400 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2002-05-15Not applicableCanada
Motrin Caplettablet200 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1996-07-172016-01-22Canada
Motrin Gelcapstablet200 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1998-02-12Not applicableCanada
Motrin Ibtablet, film coated200 mg/1oralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2000-08-01Not applicableUs
Motrin Ibtablet, coated200 mg/1oralLil' Drug Store Products, Inc.2010-05-10Not applicableUs
Motrin Ibtablet, film coated200 mg/1oralMechanical Servants, Llc2000-08-01Not applicableUs
Motrin Ibcapsule, liquid filled200 mg/1oralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2015-01-26Not applicableUs
Motrin Ib Caplet/tab 200mgtablet200 mgoralUpjohn Consumer Products Company1989-12-311996-09-10Canada
Motrin Ib Caplets 200mgtablet200 mgoralUpjohn Consumer Products Company1993-12-311996-09-10Canada
Motrin Ib Menstrual Paintablet200 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Motrin Infantssuspension/ drops50 mg/1.25mLoralJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division2001-09-01Not applicableUs
Motrin Liquid Gels 200mgcapsule200 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2007-10-31Not applicableCanada
Motrin Tablets 300mgtablet300 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1975-12-312002-05-15Canada
Motrin Tablets 400mgtablet400 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1978-12-312002-05-14Canada
Muscle & Jointtablet400 mgoralVita Health Products Inc2013-05-16Not applicableCanada
Novo-profentablet300 mgoralTeva Canada Limited1985-12-31Not applicableCanada
Novo-profentablet200 mgoralTeva Canada Limited1985-12-31Not applicableCanada
Novo-profentablet400 mgoralTeva Canada Limited1985-12-31Not applicableCanada
Nu-ibuprofen Tab 300mgtablet300 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nu-ibuprofen Tab 400mgtablet400 mgoralNu Pharm Inc1993-12-312012-09-04Canada
Nuprin Immediate Releasetablet, coated200 mg/1oralStrides Arcolab Limited2015-12-16Not applicableUs
Otis Clapp Ultraprintablet, film coated200 mg/1oralUnifirst First Aid Corporation2008-12-30Not applicableUs
Otis Clapp Ultraprintablet, coated200 mg/1oralUnifirst First Aid Corporation2016-02-01Not applicableUs
Otis Clapp Ultraprintablet, coated200 mg/1oralUnifirst First Aid Corporation2014-11-17Not applicableUs
Pain Relieftablet, coated200 mg/1oralP and L Development of New York Corporation2012-09-28Not applicableUs
Pain Relieftablet, coated200 mg/1oralP and L Development of New York Corporation2012-08-13Not applicableUs
Pain Relieftablet200 mg/1oralP and L Development of New York Corporation2013-11-30Not applicableUs
Pain Relieftablet200 mg/1oralSelect Corporation2012-10-15Not applicableUs
Pain Relief Anti Inflammatorytablet200 mg/1oralSelect Corporation2012-10-15Not applicableUs
Pain Relief Ibuprofentablet, film coated200 mg/1oralRite Aid2002-03-30Not applicableUs
Pain Relief Ibuprofentablet200 mg/1oralRite Aid1988-05-24Not applicableUs
Pamprin Ibuprofen Formulatablet400 mgoralApotex Inc2007-06-22Not applicableCanada
Pediacare Childrenssuspension100 mg/5mLoralMedtech Products Inc.2011-01-12Not applicableUs
Pediacare Infantsliquid50 mg/1.25mLoralMedtech Products Inc.2011-10-15Not applicableUs
Pendo-ibuprofentablet200 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-ibuprofen (200mg Caplet)tablet200 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Pendo-ibuprofen Establet400 mgoralPendopharm Division Of De Pharmascience IncNot applicableNot applicableCanada
Physicianscare Ibuprofentablet200 mg/1oralAcme United Corporation2011-10-07Not applicableUs
PMS-ibuprofentablet400 mgoralPharmascience Inc2008-07-09Not applicableCanada
PMS-ibuprofentablet200 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-ibuprofen (caplets)tablet200 mgoralPharmascience IncNot applicableNot applicableCanada
Preferred Plus Ibuprofentablet, film coated200 mg/1oralKinray, Inc.2013-05-11Not applicableUs
Preferred Plus Ibuprofen 200tablet200 mg/1oralKinray2013-06-26Not applicableUs
Premier Value Infants Ibuprofensuspension50 mg/1.25mLoralChain Drug Consortium, LLC2009-12-01Not applicableUs
Probufentablet400 mg/537mgoralSAMSUNG PHARM IND. CO., LTD.2011-12-01Not applicableUs
Profen Ibsuspension/ drops50 mg/1.25mLoralPublix Super Markets Inc2015-02-19Not applicableUs
Profen Ibsuspension100 mg/5mLoralPublix Super Markets Inc2003-11-18Not applicableUs
Profen Ib Childrenssuspension100 mg/5mLoralPublix Super Markets Inc2001-09-13Not applicableUs
Profen Ib Infantssuspension50 mg/1.25mLoralPublix Super Markets Inc2001-06-29Not applicableUs
Proprinaltablet, sugar coated200 mg/1oralNor Med1990-06-01Not applicableUs
Quality Choice Ibuprofen 200tablet200 mg/1oralChain Drug Marketing Association2014-07-23Not applicableUs
Regular Ibuprofentablet200 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Rexall Ibuprofensuspension100 mg/5mLoralDolgencorp Inc2010-08-19Not applicableUs
Rexall Ibuprofentablet, chewable100 mg/1oralDolgencorp, LLC2010-09-14Not applicableUs
Rexall Ibuprofentablet, film coated200 mg/1oralDolgencorp, LLC2012-09-06Not applicableUs
Rexall Ibuprofentablet, film coated200 mg/1oralDolgencorp, LLC2013-08-07Not applicableUs
Rexall Ibuprofentablet, film coated200 mg/1oralDolgencorp Inc2012-08-24Not applicableUs
Rx Act Ibuprofensuspension100 mg/5mLoralH E B2002-06-19Not applicableUs
Rx Act Ibuprofentablet, film coated200 mg/1oralH E B1994-02-04Not applicableUs
Rx Act Ibuprofentablet, film coated200 mg/1oralH E B2006-07-04Not applicableUs
Rx Act Ibuprofen Childrenssuspension100 mg/5mLoralH E B2002-06-10Not applicableUs
Rx Act Ibuprofen Childrenssuspension100 mg/5mLoralH E B1999-01-06Not applicableUs
Shoprite Childrens Ibuprofensuspension100 mg/5mLoralWakefern Food Corporation2013-08-19Not applicableUs
Shoprite Childrens Ibuprofensuspension100 mg/5mLoralWakefern Food Corporation2013-06-20Not applicableUs
Shoprite Ibuprofentablet, film coated200 mg/1oralWakefern Food Corporation2013-08-06Not applicableUs
Shoprite Ibuprofensuspension100 mg/5mLoralWakefern Food Corporation2014-05-12Not applicableUs
Shoprite Ibuprofentablet, coated200 mg/1oralWakefern Food Corporation2013-08-06Not applicableUs
Shoprite Ibuprofen Ibtablet, film coated200 mg/1oralWakefern Food Corporation2013-08-06Not applicableUs
Shoprite Ibuprofen Ibtablet, chewable100 mg/1oralWakefern Food Corporation2013-07-02Not applicableUs
Shoprite Ibuprofen Ibtablet, coated200 mg/1oralWakefern Food Corporation2013-08-06Not applicableUs
Shoprite Infants Ibuprofensuspension/ drops50 mg/1.25mLoralWakefern Food Corporation2013-06-17Not applicableUs
Signature Care Childrens Ibuprofensuspension100 mg/5mLoralSafeway2015-09-01Not applicableUs
Signature Care Childrens Ibuprofensuspension100 mg/5mLoralSafeway2015-09-04Not applicableUs
Signature Care Childrens Ibuprofensuspension100 mg/5mLoralSafeway2015-09-01Not applicableUs
Signature Care Ibuprofentablet, chewable100 mg/1oralSafeway2015-09-29Not applicableUs
Signature Care Ibuprofentablet, film coated200 mg/1oralSafeway2015-08-12Not applicableUs
Signature Care Ibuprofentablet, film coated200 mg/1oralSafeway2015-09-14Not applicableUs
Signature Care Ibuprofentablet, coated200 mg/1oralSafeway2015-09-14Not applicableUs
Signature Care Ibuprofen Childrenssuspension100 mg/5mLoralSafeway2015-08-19Not applicableUs
Signature Care Infants Ibuprofensuspension/ drops50 mg/1.25mLoralSafeway2015-09-28Not applicableUs
Simply Right Ibuprofentablet, film coated200 mg/1oralSam's West Inc2011-12-18Not applicableUs
Smart Sense Ibuprofentablet, film coated200 mg/1oralKmart Corporation2010-06-04Not applicableUs
Smart Sense Ibuprofensuspension100 mg/5mLoralKmart Corporation2010-05-20Not applicableUs
Smart Sense Ibuprofentablet, chewable100 mg/1oralKmart Corporation2010-06-24Not applicableUs
Smart Sense Ibuprofensuspension/ drops50 mg/1.25mLoralKmart Corporation2010-05-14Not applicableUs
Smart Sense Ibuprofensuspension100 mg/5mLoralKmart Corporation2010-05-20Not applicableUs
Smart Sense Ibuprofensuspension100 mg/5mLoralKmart Corporation2010-05-20Not applicableUs
Smart Sense Ibuprofentablet, coated200 mg/1oralKmart Corporation2010-06-17Not applicableUs
Smart Sense Ibuprofentablet, coated200 mg/1oralKmart Corporation2010-06-21Not applicableUs
Smart Sense Ibuprofen Gluten Freetablet, film coated200 mg/1oralKmart Corporation2010-06-18Not applicableUs
Smart Sense Ibuprofen Infantssuspension50 mg/1.25mLoralKmart Corporation2010-07-01Not applicableUs
Sound Body Ibuprofentablet, film coated200 mg/1oralBig Lots Stores, Inc.2015-04-21Not applicableUs
Sunmark Ibuprofentablet, film coated200 mg/1oralMc Kesson2003-06-24Not applicableUs
Sunmark Ibuprofensuspension100 mg/5mLoralMc Kesson2003-09-19Not applicableUs
Sunmark Ibuprofensuspension/ drops50 mg/1.25mLoralMc Kesson2004-04-29Not applicableUs
Sunmark Ibuprofentablet, coated200 mg/1oralMc Kesson2003-06-24Not applicableUs
Sunmark Ibuprofen Childrenssuspension100 mg/5mLoralMc Kesson2009-04-01Not applicableUs
Sunmark Ibuprofen Childrenssuspension100 mg/5mLoralMc Kesson2003-09-19Not applicableUs
Sunmark Ibuprofen Childrenssuspension100 mg/5mLoralMc Kesson2003-06-24Not applicableUs
Sunmark Ibuprofen Childrenssuspension100 mg/5mLoralMc Kesson2003-09-06Not applicableUs
Sunmark Ibuprofen Ibtablet, chewable100 mg/1oralMc Kesson2004-07-10Not applicableUs
Sunmark Ibuprofen Ibtablet, film coated200 mg/1oralMc Kesson2006-04-28Not applicableUs
Sunmark Ibuprofen Ibtablet, coated200 mg/1oralMc Kesson2006-03-20Not applicableUs
Sunmark Ibuprofen Infantssuspension50 mg/1.25mLoralMc Kesson2003-08-28Not applicableUs
Super Strength Motrin Ib Liquid Gelscapsule400 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2009-07-06Not applicableCanada
Super Strength Motrin Ib Liquid Gels Capsulescapsule400 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson Inc2012-07-30Not applicableCanada
Super Strength Motrin Ib Menstrual Paintablet400 mgoralMcneil Consumer Healthcare Division Of Johnson & Johnson IncNot applicableNot applicableCanada
Topcare Childrens Ibuprofensuspension100 mg/5mLoralTopco Associates LLC2002-07-02Not applicableUs
Topcare Childrens Ibuprofensuspension100 mg/5mLoralTopco Associates LLC2002-07-30Not applicableUs
Topcare Ibuprofentablet, coated200 mg/1oralTopco Associates LLC2006-04-10Not applicableUs
Topcare Ibuprofentablet, film coated256 mg/1oralTopco Associates LLC2016-03-23Not applicableUs
Topcare Ibuprofentablet, film coated200 mg/1oralTopco Associates LLC1993-04-22Not applicableUs
Topcare Ibuprofensuspension100 mg/5mLoralTopco Associates LLC1998-12-31Not applicableUs
Topcare Ibuprofensuspension/ drops50 mg/1.25mLoralTopco Associates LLC2004-09-10Not applicableUs
Topcare Ibuprofentablet, coated200 mg/1oralTopco Associates LLC1988-11-15Not applicableUs
Topcare Ibuprofentablet200 mg/1oralTopco Associates LLC1988-02-15Not applicableUs
Topcare Ibuprofentablet, film coated200 mg/1oralTopco Associates LLC2006-04-28Not applicableUs
Topcare Ibuprofen Childrenssuspension100 mg/5mLoralTopco Associates LLC1995-02-03Not applicableUs
Topcare Ibuprofen Junior Strengthtablet, chewable100 mg/1oralTopco Associates LLC2004-05-28Not applicableUs
Topcare Infants Ibuprofensuspension50 mg/1.25mLoralTopco Associates LLC2002-01-22Not applicableUs
Up and Up Childrens Ibuprofensuspension100 mg/5mLoralTarget Corporation2009-06-12Not applicableUs
Up and Up Childrens Ibuprofensuspension100 mg/5mLoralTarget Corporation2009-06-12Not applicableUs
Up and Up Childrens Ibuprofensuspension100 mg/5mLoralTarget Corporation2009-07-08Not applicableUs
Up and Up Childrens Ibuprofen Oral Suspensionsuspension100 mg/5mLoralTarget Corporation2009-07-08Not applicableUs
Up and Up Dye Free Infants Concentrated Ibuprofensuspension/ drops50 mg/1.25mLoralTarget Corporation2009-07-08Not applicableUs
Up and Up Ibuprofensuspension100 mg/5mLoralTarget Corporation2009-07-10Not applicableUs
Up and Up Ibuprofentablet200 mg/1oralTarget Corporation2009-05-28Not applicableUs
Up and Up Ibuprofentablet200 mg/1oralTarget Corporation2009-05-28Not applicableUs
Up and Up Ibuprofentablet, film coated200 mg/1oralTarget Corporation2009-06-10Not applicableUs
Up and Up Ibuprofentablet, film coated200 mg/1oralTarget Corporation2010-03-11Not applicableUs
Up and Up Ibuprofen Juniortablet, chewable100 mg/1oralTarget Corporation2013-03-04Not applicableUs
Up and Up Junior Strength Ibuprofentablet, chewable100 mg/1oralTarget Corporation2010-06-22Not applicableUs
Welby Health Ibuprofenliquid100 mg/5mLoralAldi, Inc2009-12-09Not applicableUs
Welby Health Ibuprofentablet200 mg/1oralAldi, Inc1993-06-01Not applicableUs
Welby Ibuprofentablet, film coated200 mg/1oralAldi, Inc2016-01-07Not applicableUs
Zee Ibutabtablet200 mg/1oralZee Medical Inc2015-09-10Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ibuprofentablet200 mg/1oralCardinal Health2011-06-02Not applicableUs
International Brands
NameCompany
Act-3Healthcare Logistics
ActiprofenSterling Health
AdexDexxon
AdranNot Available
AktrenBayer
Alges-XAxapharm
AlgoflexChinoin
AlgofrenIntermed
AliviumBristol-Myers Squibb
ArtofenTeva
BetagesicAdcock Ingram Pharmaceuticals
BetaprofenBe-Tabs Pharmaceuticals
BlutonNot Available
BonifenKrka
BrufenAbbott
BuburoneTowa Yakuhin
BugesicNot Available
BuprovilNot Available
BuranaOrion
ButyleninNot Available
CalprofenMcNeil
Cap-ProfenPERRIGO
Children's ElixsurePfizer
Children's IbuprofenPfizer
DalsyAbbott
DismenolMerz
DiverinNot Available
DolgiridNot Available
DolgitDolorgiet
DolofortNot Available
DolorazNot Available
DolorminNot Available
DorivalNot Available
EbufacNot Available
EmuProfenNot Available
EpobronNot Available
EspidifenNot Available
EveNot Available
FemadonNot Available
FenbidNot Available
FenpaedNot Available
FinalflexNot Available
GalprofenNot Available
HaltranNot Available
Herron BlueNot Available
i-profen Not Available
IbalginNot Available
Ibu-AttritinNot Available
IBU-RatiopharmNot Available
Ibu-VivimedNot Available
IbuflamNot Available
IbugelNot Available
IbugesicNot Available
IbuHEXALNot Available
IbuleveNot Available
IbumNot Available
IbumaxNot Available
IbumetinNot Available
IbumidolNot Available
IbupainNot Available
IbuprocinNot Available
IbupromNot Available
IbuprosynNot Available
IbuproxNot Available
IbustarNot Available
IbutidNot Available
IbuxNot Available
IbuxinNot Available
InabrinNot Available
InovenNot Available
IprenNot Available
Junior Strength MotrinNot Available
KratalginNot Available
LamidonNot Available
LebrufenNot Available
LiptanNot Available
LotemNot Available
MedicolNot Available
MediprenNot Available
Midol IBNot Available
MotrinNot Available
MynosedinNot Available
MypaidNot Available
MyprodolNot Available
NarfenNot Available
Naron Ace Not Available
NeobrufenNot Available
NobfenNot Available
NobgenNot Available
NorvectanNot Available
NuprinNot Available
NureflexNot Available
NurofenNot Available
OrbifenNot Available
PanafenNot Available
PediaprofenNot Available
PerifarNot Available
ProfinNot Available
RanfenNot Available
RapidolNot Available
RatiodolorNot Available
RimafenNot Available
RoideninNot Available
RufenNot Available
SalvarinaNot Available
SeclodinNot Available
SolpaflexNot Available
Speedpain NANONot Available
SpidifenZambon
SusprenNot Available
TabalonNot Available
TefinNot Available
TrendarNot Available
UnafenNot Available
UpfenNot Available
UremNot Available
Brand mixtures
NameLabellerIngredients
10 Person AnsiGenuine First Aid LLC
25 Person AnsiGenuine First Aid LLC
50 Person AnsiGenuine First Aid LLC
7 Select Ibuprofen PM7 Eleven
7-select Advil PMLil' Drug Store Products, Inc
Advil Allergy and Congestion ReliefPfizer Consumer Healthcare
Advil Allergy SinusPfizer Consumer Healthcare
Advil Back PainPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold & FluPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold & Sinus Convenience PackPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold & Sinus Liqui-gelsPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold & Sinus PEPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold and SinusPfizer Consumer Healthcare
Advil Cold and Sinus DaytimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold and Sinus NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold and Sinus PlusPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Cold, Cough & Flu NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Congestion ReliefPfizer Consumer Healthcare
Advil Day/night Convenience PackPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil NighttimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil Pain & Head Cold NightPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Advil PMPfizer Consumer Healthcare
Advil Sinus Congestion and PainPfizer Consumer Healthcare
Analgesic and Muscle RelaxantPharmascience Inc
Analgesic and Muscle Relaxant CapletsTeva Canada Limited
Army and Airforce Exchange Ibuprofen PMArmy & Air Force Exchange Service
Auto 157Genuine First Aid LLC
AxumTeva Canada Limited
Berkley and Jensen Ibuprofen PMBJWC
Care One Ibuprofen Cold and SinusAmerican Sales Company
Care One Ibuprofen PMAmerican Sales Company
Careone Ibuprofen PMAmerican Sales Company
Children's Advil ColdPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Children's Advil Cold & Flu Multi-symptomPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Children's Motrin ColdMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Childrens Advil ColdPfizer Consumer Healthcare
CodofenPaladin Labs Inc
Cold & Sinus Relief CapsulesApotex Inc
Cold + SinusVita Health Products Inc
Cold + Sinus CapletsVita Health Products Inc
Cold + Sinus DaytimeVita Health Products Inc
Cold + Sinus Daytime Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus NighttimeVita Health Products Inc
Cold + Sinus PlusVita Health Products Inc
Cold and Sinus Pain ReliefSafeway
Cold and Sinus PlusInternational Pharmaceutical Generics Ltd
Cold and Sinus ReliefCVS Pharmacy
Congestion ReliefMeijer Distribution Inc
Dg Health Ibuprofen PMDolgencorp Inc
Dimetapp Cold and Sinus CapletsWhitehall Robins Inc.
Dristan Sinus CapletsWhitehall Robins Inc.
DuexisHorizon Pharma Inc.
Equaline Congestion ReliefSupervalu Inc
Equaline Ibuprofen Cold and SinusSupervalu Inc
Equaline Ibuprofen PMSupervalu Inc
Equate Ibuprofen Cold and SinusWal Mart Stores Inc
Equate Ibuprofen PMWal Mart Stores Inc
Genuine First Aid - Auto First AidGenuine First Aid, LLC
Genuine First Aid - Home First AidGenuine First Aid, LLC
Genuine First Aid Industrial First AidGenuine First Aid, LLC
Gfa First Aid Kit Essentials - 33 PiecesGenuine First Aid, LLC
Good Neighbor Pharmacy Childrens Ibuprofen ColdAmerisource Bergen
Good Neighbor Pharmacy Congestion ReliefAmerisource Bergen
Good Neighbor Pharmacy Ibuprofen Cold and SinusAmerisource Bergen
Good Neighbor Pharmacy Ibuprofen PMAmerisource Bergen
Good Sense Ibuprofen Cold and SinusL Perrigo Company
Good Sense Ibuprofen PML Perrigo Company
Harris Teeter Ibuprofen PMHarris Teeter, LLC
Healthy Accents Congestion ReliefDZA Brands LLC
Healthy Accents Ibuprofen PMDZA Brands LLC
Hydrocodone BitartrateDIRECT RX
Hydrocodone Bitartrate and IbuprofenTeva Pharmaceuticals USA Inc
Ibu Profen Cold and SinusRite Aid Corporation
IbucodonePaladin Labs Inc
IbudonePoly Pharmaceuticals
Ibuprofen + Pseudoephedrine CapletsInternational Pharmaceutical Generics Ltd
Ibuprofen and Diphenhydramine CitrateDr. Reddy's Laboratories Limited
Ibuprofen and Diphenhydramine HClP and L Development of New York Corporation
Ibuprofen and PseudoephedrineMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Ibuprofen and Pseudoephedrine HydrochlorideWalgreen Company
Ibuprofen Cold and SinusKroger Company
Ibuprofen Cold and Sinus A P JA P J Laboratories Limited
Ibuprofen Cold ChildrensMeijer Distribution Inc
Ibuprofen Cold Relief ChildrensCVS Pharmacy
Ibuprofen Daytime, Ibuprofen NighttimeVita Health Products Inc
Ibuprofen NighttimeVita Health Products Inc
Ibuprofen PMWalgreen Company
Ibuprofen+methocarbamol CapletsInternational Pharmaceutical Generics Ltd
Leader Congestion ReliefCardinal Health
Leader Ibuprofen Cold and SinusCardinal Health
Leader Ibuprofen Cold ChildrensCardinal Health
Leader Ibuprofen PMCardinal Health
Motrin Cold & Sinus CapletsMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Motrin Cold & Sinus PainMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Motrin Platinum Muscle and BodyMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Motrin PMJohnson & Johnson Consumer Inc., Mc Neil Consumer Healthcare Division
Mountain Series Weekender MedicalTender Corporation Dba Adventure Medical Kits
Muscle & Back Pain Relief With IbuprofenTeva Canada Limited
Muscle and Back Pain Platinum ReliefVita Health Products Inc
Muscle Relaxant and Analgesic CapletsInternational Pharmaceutical Generics Ltd
Nighttime Pain ReliefApotex Inc
Nighttime Pain RelieverInternational Pharmaceutical Generics Ltd
Oxycodone Hydrochloride and IbuprofenActavis Elizabeth LLC
Platinum Muscle and Back Pain ReliefVita Health Products Inc
PrasteraHealth Science Funding, Llc
Preferred Plus Congestion ReliefKinray
Ready America First Aid Outdoor- 107 PiecesGenuine First Aid, LLC
Ready America First Aid Pocket - 33 PiecesGenuine First Aid, LLC
Regular Strength Analgesic & Muscle Relaxant CapletsTeva Canada Limited
ReprexainStat Rx USA
Robax PlatinumPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Rugby Congestion ReliefRugby Laboratories
Rx Act Ibuprofen PMH E B
Shoprite Ibuprofen PMWakefern Food Corporation
Signature Care Ibuprofen PMSafeway
Smart Sense Ibuprofen PMKmart Corporation
Sudafed Sinus AdvanceMcneil Consumer Healthcare Division Of Johnson & Johnson Inc
Summit UltraPendopharm Division Of De Pharmascience Inc
Sunmark Ibuprofen Cold and SinusMc Kesson
Sunmark Ibuprofen PMMc Kesson
Theraprofen-60Physician Therapeutics Llc
Theraprofen-800Physician Therapeutics Llc
Theraprofen-90Physician Therapeutics Llc
Topcare Congestion ReliefTopco Associates LLC
Topcare Ibuprofen Cold and SinusTopco Associates LLC
Topcare Ibuprofen PMTopco Associates LLC
Up and Up Cold and SinusTarget Corporation
Up and Up Ibuprofen PMTarget Corporation
Vicks Dayquil Sinus Pr.and Pain ReL.W.ibupr.Procter & Gamble Inc
VicoprofenAbb Vie Inc.
Wal Profen Cold and SinusWalgreen Company
Xylon 10Sircle Laboratories, Llc
Salts
Name/CASStructureProperties
Ibuprofen lysine
ThumbNot applicableDBSALT001397
Ibuprofen sodium
ThumbNot applicableDBSALT001483
Categories
UNIIWK2XYI10QM
CAS number15687-27-1
WeightAverage: 206.2808
Monoisotopic: 206.13067982
Chemical FormulaC13H18O2
InChI KeyInChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N
InChI
InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
IUPAC Name
2-[4-(2-methylpropyl)phenyl]propanoic acid
SMILES
CC(C)CC1=CC=C(C=C1)C(C)C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylpropanoic acids. These are compounds with a structure containing a benzene ring conjugated to a propanoic acid.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassPhenylpropanoic acids
Sub ClassNot Available
Direct ParentPhenylpropanoic acids
Alternative Parents
Substituents
  • 2-phenylpropanoic-acid
  • Phenylacetate
  • Monoterpenoid
  • Monocyclic monoterpenoid
  • Aromatic monoterpenoid
  • P-cymene
  • Phenylpropane
  • Benzenoid
  • Monocyclic benzene moiety
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor symptomatic treatment of rheumatoid arthritis, juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis, gout and psoriatic arthritis. May reduce pain, fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.
PharmacodynamicsIbuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, which are thought to act through inhibition of prostaglandin synthesis.
Mechanism of actionThe exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration. Ibuprofen is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer.
Related Articles
Absorption~ 80% absorbed from GI tract

Time to reach peak plasma concentration = 47 minutes (suspension), 62 minutes (chewable tablets), 120 minutes (conventional tablets)

Volume of distributionNot Available
Protein binding90-99% to whole human plasma and site II of purified albumin, binding appears to be saturable and becomes non-linear at concentrations exceeding 20 mcg/ml.
Metabolism

R-enanatiomer undergoes extensive enantiomeric conversion (53-65%) to the more active S-enantiomer in vivo. Metablized by oxidation to 2 inactive metabolites: (+)-2[4´-(2-hydroxy-2-methylpropyl)phenyl]propionic acid and (+)-2-[4´-(2-carboxypropyl)phenyl]propionic acid. Very small amounts of 1-hydroxyibuprofen and 3-hydroxyibuprofen have been recovered from urine. Cytochrome P450 2C9 is the major catalyst in the formation of oxidative metabolites. Oxidative metabolites may be conjugated to glucuronide prior to excretion.

SubstrateEnzymesProduct
Ibuprofen
Ibuprofen glucuronideDetails
Ibuprofen
2-HydroxyibuprofenDetails
Ibuprofen
3-HydroxyibuprofenDetails
Ibuprofen
Not Available
1-hydroxyibuprofenDetails
3-Hydroxyibuprofen
Carboxy-ibuprofenDetails
Route of eliminationIbuprofen is rapidly metabolized and eliminated in the urine.
Half life2-4 hours
ClearanceNot Available
Toxicity

Side effects: May cause peripheral edema and fluid retention. Use caution in patients with congestive heart failure or severe uncontrolled hypertension. May cause dyspepsia, heartburn, nausea, vomiting, anorexia, diarrhea, constipation, stomatitis, flatulence, bloating, epigastric pain, and abdominal pain. Peptic ulcer and GI bleeding have been reported. May also cause dizziness, headache and nervousness. Acute renal failure accompanied by acute tubular necrosis has been reported.

Most common symptoms of overdose are abdominal pain, nausea, vomiting, lethargy, vertigo, drowsiness (somnolence), dizziness and insomnia. Other symptoms of overdose include headache, loss of consciousness, tinnitus, CNS depression, convulsions and seizures. May rarely cause metabolic acidosis, abnormal hepatic function, hyperkalemia, renal failure, dyspnea, respiratory depression, coma, acute renal failure, and apnea (primarily in very young pediatric patients).

LD50=1255mg/kg(orally in mice)

Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Ibuprofen Action PathwayDrug actionSMP00086
Ibuprofen Metabolism PathwayDrug metabolismSMP00590
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9927
Blood Brain Barrier+0.9619
Caco-2 permeable+0.8866
P-glycoprotein substrateNon-substrate0.759
P-glycoprotein inhibitor INon-inhibitor0.9705
P-glycoprotein inhibitor IINon-inhibitor0.9323
Renal organic cation transporterNon-inhibitor0.9323
CYP450 2C9 substrateNon-substrate0.7594
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.6877
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9305
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9881
CYP450 3A4 inhibitorNon-inhibitor0.9655
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9691
Ames testNon AMES toxic0.9894
CarcinogenicityCarcinogens 0.5553
BiodegradationReady biodegradable0.5142
Rat acute toxicity2.3092 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9719
hERG inhibition (predictor II)Non-inhibitor0.9734
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, coatedoral256 mg/1
Capsuleoral
Kit; capsuleoral
Capsuleoral400 mg
Capsuleoral200 mg
Tabletoral400 mg/400mg
Tabletoral600 mg/600mg
Tabletoral800 mg/800mg
Tabletoral300 mg
Tabletoral200 mg
Injectionintravenous800 mg/8mL
Solutionintravenous100 mg
Suspensionoral100 mg
Tablet (chewable)oral50 mg
Tabletoral50 mg
Suspensionoral
Solutionoral100 mg/5mL
Suspensionoral200 mg/10mL
Kit; tabletoral
Kit
Tabletoral200 mg/1
Capsule, liquid filledoral200 mg/1
Tablet, chewableoral100 mg/1
Tablet, coatedoral200 mg/1
Tablet, film coatedoral200 mg/1
Suspensionoral100 mg/5mL
Tablet, sugar coatedoral
Suspensionoral50 mg/1.25mL
Tablet, coatedoral
Tabletoral600 mg/1
Tabletoral800 mg/1
Capsule, coatedoral200 mg/1
Capsule, liquid filledoral220 mg/1
Liquidoral100 mg/5mL
Suspension/ dropsoral50 mg/1.25mL
Tabletoral100 mg/1
Tabletoral400 mg/1
Tabletoral800 1/1
Tablet, coatedoral400 mg/1
Tablet, coatedoral600 mg/1
Tablet, coatedoral800 mg/1
Tablet, film coatedoral200 1/1
Tablet, film coatedoral400 mg/400mg
Tablet, film coatedoral400 mg/1
Tablet, film coatedoral400 mg/301
Tablet, film coatedoral600 mg/600mg
Tablet, film coatedoral600 mg/1
Tablet, film coatedoral800 mg/1
Tablet, film coatedoral800 mg/800mg
Capsuleoral200 mg/1
Capsule, liquid filledoral
Tablet, film coatedoral256 mg/1
Suspensionoral40 mg
Liquidoral50 mg/1.25mL
Tablet (chewable)oral100 mg
Tablet, coatedoral100 mg/1
Tabletoral100 mg
Kit
Solutionintravenous10 mg/mL
Tabletoral400 mg
Tabletoral600 mg
Kitoral
Tabletoral400 mg/537mg
Tablet, sugar coatedoral200 mg/1
Tabletoral
Tablet, film coatedoral
Prices
Unit descriptionCostUnit
Neoprofen 20 mg/2 ml vial304.5USD ml
Caldolor 400 mg/4 ml vial2.21USD ml
Caldolor 800 mg/8 ml vial1.58USD ml
Nuprin arthritis patch1.11USD patch
Ibuprofen powder1.04USD g
Nuprin muscle & joint patch1.03USD patch
Profen II 45-800 mg 12 Hour tablet0.69USD tablet
Motrin 800 mg tablet0.59USD tablet
Advil allergy sinus caplet0.5USD caplet
Ibu-drops 40 mg/ml suspension drops0.42USD ml
Motrin 600 mg tablet0.4USD tablet
Ibuprofen 800 mg tablet0.36USD tablet
Ibuprofen 400 mg tablet0.35USD tablet
Infant's motrin 50 mg/1.25 ml0.34USD ml
Childs ibuprofen susp drp0.33USD ml
Ibuprofen 600 mg tablet0.33USD tablet
Wal-profen cold & sinus cplt0.3USD caplet
Infant ibuprofen susp drop0.29USD ml
Motrin 400 mg tablet0.29USD tablet
CVS Pharmacy infant ibuprofen susp drop0.25USD ml
Infants medi-profen susp0.23USD ml
Advil cold & sinus caplet0.22USD caplet
Advil pm caplet0.22USD caplet
Soba profen cold-sinus tablet0.22USD tablet
Midol caplet0.21USD caplet
Advil migraine 200 mg capsule0.2USD capsule
Ibuprofen cold-sinus caplet0.2USD caplet
Motrin 100 mg caplet0.2USD caplet
Motrin pm caplet0.2USD caplet
Advil 200 mg liqui-gel capsule0.19USD capsule
Soba profen ib caplet0.19USD caplet
Motrin 100 mg tablet chew0.18USD tablet
Pub infants profenib drops0.18USD ml
Sm ibuprofen ib 100 mg tablet0.18USD tablet
Eck ibuprofen jr caplet0.17USD caplet
Ibuprofen pm caplet0.17USD caplet
Advil 200 mg caplet0.15USD capsule
Advil 200 mg gel caplet0.15USD caplet
Advil 200 mg tablet0.15USD tablet
Ibuprofen 100 mg tablet chew0.15USD tablet
Motrin ib 200 mg caplet0.15USD caplet
Apo-Ibuprofen 600 mg Tablet0.14USD tablet
CVS Pharmacy ibuprofen jr str 100 mg tablet0.14USD tablet
Nu-Ibuprofen 600 mg Tablet0.14USD tablet
Motrin ib 200 mg tablet0.13USD tablet
Motrin ib 200 mg gelcap0.12USD capsule
Nuprin 200 mg caplet0.12USD caplet
Wal-profen 200 mg caplet0.12USD caplet
Wal-profen 200 mg tablet0.12USD tablet
Eql ibuprofen 200 mg tablet0.1USD tablet
Nuprin 200 mg tablet0.1USD tablet
Apo-Ibuprofen 400 mg Tablet0.08USD tablet
Ibuprofen ib 200 mg tablet0.08USD tablet
Novo-Profen 400 mg Tablet0.08USD tablet
Apo-Ibuprofen 300 mg Tablet0.07USD tablet
Medi-profen 200 mg tablet0.07USD tablet
Ibuprofen 100 mg/5ml Suspension0.06USD ml
Ibuprofen 200 mg caplet0.06USD caplet
Child ibuprofen susp0.05USD ml
Children's medi-profen susp0.05USD ml
Children's motrin cold suspension0.05USD ml
CVS Pharmacy ibuprofen 200 mg tablet0.05USD tablet
Ibuprofen cold suspension0.05USD ml
I-prin 200 mg tablet0.05USD tablet
Novo-Profen 600 mg Tablet0.05USD tablet
Children's motrin cold0.04USD ml
Pv ibuprofen 200 mg caplet0.04USD caplet
Soba children's profenib susp0.04USD ml
Ibuprofen 200 mg tablet0.03USD tablet
CVS Pharmacy ibuprofen 200 mg caplet0.02USD caplet
Pv ibuprofen 200 mg tablet0.02USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5215755 No1993-06-012010-06-01Us
US6211246 No1999-06-102019-06-10Us
US6251426 No1998-06-252018-06-25Us
US6342530 No2000-11-142020-11-14Us
US6344479 No2001-03-202021-03-20Us
US6348216 No1997-06-102017-06-10Us
US6599531 No1997-06-102017-06-10Us
US6727286 No2001-11-272021-11-27Us
US7863287 No2007-02-282027-02-28Us
US8067033 No2006-07-182026-07-18Us
US8067451 No2006-07-182026-07-18Us
US8263647 No2002-05-302022-05-30Us
US8309127 No2006-07-182026-07-18Us
US8318202 No2006-07-182026-07-18Us
US8415337 No2012-03-022032-03-02Us
US8449910 No2006-07-182026-07-18Us
US8501228 No2006-07-182026-07-18Us
US8735452 No2009-09-302029-09-30Us
US8871810 No2009-09-302029-09-30Us
US8883849 No2002-01-172022-01-17Us
US9012508 No2010-09-142030-09-14Us
US9114068 No2009-09-302029-09-30Us
US9138404 No2009-09-302029-09-30Us
US9155718 No2002-01-172022-01-17Us
US9295639 No2009-09-302029-09-30Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point75-77.5U.S. Patent 3,228,831 U.S. Patent 3,385,886
water solubility21 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.97AVDEEF,A (1997)
logS-3.99ADME Research, USCD
Caco2 permeability-4.28ADME Research, USCD
pKa4.91SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0684 mg/mLALOGPS
logP3.5ALOGPS
logP3.84ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)4.85ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity60.73 m3·mol-1ChemAxon
Polarizability23.76 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (11.4 KB)
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-02t9-1910000000-23f448d7be7d5cc35682View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-02t9-1910000000-cbe52d63986b68a2cec0View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (1 TMS)splash10-00di-9300000000-cc259b7768023e4cdba8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-03di-0910000000-90bf6813134491c9fbfdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-001i-9800000000-56f599abc462380b648cView in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (HITACHI RMU-6E) , Positivesplash10-03di-3910000000-618880f8fd7b8ec3d473View in MoNA
MSMass Spectrum (Electron Ionization)splash10-03xr-3900000000-e20ef3c30496e17720baView in MoNA
1D NMR1H NMR SpectrumNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

http://en.wikipedia.org/wiki/Ibuprofen#Synthesis

General References
  1. Zawada ET Jr: Renal consequences of nonsteroidal antiinflammatory drugs. Postgrad Med. 1982 May;71(5):223-30. [PubMed:7041104 ]
  2. Townsend KP, Pratico D: Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. FASEB J. 2005 Oct;19(12):1592-601. [PubMed:16195368 ]
  3. Chen H, Jacobs E, Schwarzschild MA, McCullough ML, Calle EE, Thun MJ, Ascherio A: Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease. Ann Neurol. 2005 Dec;58(6):963-7. [PubMed:16240369 ]
  4. Geisslinger G, Dietzel K, Bezler H, Nuernberg B, Brune K: Therapeutically relevant differences in the pharmacokinetical and pharmaceutical behavior of ibuprofen lysinate as compared to ibuprofen acid. Int J Clin Pharmacol Ther Toxicol. 1989 Jul;27(7):324-8. [PubMed:2777420 ]
  5. Bergner T, Przybilla B: Photosensitization caused by ibuprofen. J Am Acad Dermatol. 1992 Jan;26(1):114-6. [PubMed:1531054 ]
  6. Dill J, Patel AR, Yang XL, Bachoo R, Powell CM, Li S: A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons. J Neurosci. 2010 Jan 20;30(3):963-72. doi: 10.1523/JNEUROSCI.5045-09.2010. [PubMed:20089905 ]
External Links
ATC CodesM02AA13C01EB16R02AX02M01AE51M01AE01G02CC01
AHFS Codes
  • 28:08.04.92
PDB EntriesNot Available
FDA labelDownload (1.77 MB)
MSDSDownload (73.5 KB)
Interactions
Drug Interactions
Drug
AbciximabIbuprofen may increase the anticoagulant activities of Abciximab.
AcenocoumarolIbuprofen may increase the anticoagulant activities of Acenocoumarol.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Acetylsalicylic acid.
AliskirenIbuprofen may decrease the antihypertensive activities of Aliskiren.
AlteplaseIbuprofen may increase the anticoagulant activities of Alteplase.
AmikacinIbuprofen may decrease the excretion rate of Amikacin which could result in a lower serum level and potentially a reduction in efficacy.
AmitriptylineAmitriptyline may increase the antiplatelet activities of Ibuprofen.
AnistreplaseIbuprofen may increase the anticoagulant activities of Anistreplase.
ApixabanThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Apixaban.
ArbekacinIbuprofen may decrease the excretion rate of Arbekacin which could result in a lower serum level and potentially a reduction in efficacy.
BalsalazideIbuprofen may increase the nephrotoxic activities of Balsalazide.
Citric AcidIbuprofen may increase the anticoagulant activities of Citric Acid.
ColesevelamColesevelam can cause a decrease in the absorption of Ibuprofen resulting in a reduced serum concentration and potentially a decrease in efficacy.
CollagenaseThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Collagenase.
CyclosporineIbuprofen may increase the nephrotoxic activities of Cyclosporine.
Dabigatran etexilateIbuprofen may increase the anticoagulant activities of Dabigatran etexilate.
DalteparinIbuprofen may increase the anticoagulant activities of Dalteparin.
DasatinibDasatinib may increase the anticoagulant activities of Ibuprofen.
DeferasiroxThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Deferasirox.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Deoxycholic Acid.
DesmopressinThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Desmopressin.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Ibuprofen.
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Ibuprofen.
DicoumarolIbuprofen may increase the anticoagulant activities of Dicoumarol.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Ibuprofen.
DrospirenoneIbuprofen may increase the hyperkalemic activities of Drospirenone.
Edetic AcidIbuprofen may increase the anticoagulant activities of Edetic Acid.
EnoxaparinIbuprofen may increase the anticoagulant activities of Enoxaparin.
EplerenoneIbuprofen may decrease the antihypertensive activities of Eplerenone.
Ethyl biscoumacetateIbuprofen may increase the anticoagulant activities of Ethyl biscoumacetate.
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Ibuprofen.
FludrocortisoneThe risk or severity of adverse effects can be increased when Fludrocortisone is combined with Ibuprofen.
Fondaparinux sodiumIbuprofen may increase the anticoagulant activities of Fondaparinux sodium.
FramycetinIbuprofen may decrease the excretion rate of Framycetin which could result in a lower serum level and potentially a reduction in efficacy.
GentamicinIbuprofen may decrease the excretion rate of Gentamicin which could result in a lower serum level and potentially a reduction in efficacy.
GlucosamineGlucosamine may increase the antiplatelet activities of Ibuprofen.
HaloperidolThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Haloperidol.
HeparinIbuprofen may increase the anticoagulant activities of Heparin.
HydralazineIbuprofen may decrease the antihypertensive activities of Hydralazine.
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Ibritumomab.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Ibuprofen.
IcosapentThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Icosapent.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Ibuprofen.
InfliximabThe risk or severity of adverse effects can be increased when Infliximab is combined with Ibuprofen.
KanamycinIbuprofen may decrease the excretion rate of Kanamycin which could result in a lower serum level and potentially a reduction in efficacy.
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Ibuprofen.
LimaprostLimaprost may increase the antiplatelet activities of Ibuprofen.
LithiumThe serum concentration of Lithium can be increased when it is combined with Ibuprofen.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Ibuprofen.
MorniflumateThe risk or severity of adverse effects can be increased when Morniflumate is combined with Ibuprofen.
NadololIbuprofen may decrease the antihypertensive activities of Nadolol.
NeomycinIbuprofen may decrease the excretion rate of Neomycin which could result in a lower serum level and potentially a reduction in efficacy.
NetilmicinIbuprofen may decrease the excretion rate of Netilmicin which could result in a lower serum level and potentially a reduction in efficacy.
ObinutuzumabThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Obinutuzumab.
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Homoharringtonine.
Omega-3 fatty acidsOmega-3 fatty acids may increase the antiplatelet activities of Ibuprofen.
PamidronateThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Pamidronate.
ParoxetineParoxetine may increase the antiplatelet activities of Ibuprofen.
PemetrexedThe serum concentration of Pemetrexed can be increased when it is combined with Ibuprofen.
Pentosan PolysulfateThe risk or severity of adverse effects can be increased when Pentosan Polysulfate is combined with Ibuprofen.
PentoxifyllinePentoxifylline may increase the antiplatelet activities of Ibuprofen.
PerindoprilThe risk or severity of adverse effects can be increased when Perindopril is combined with Ibuprofen.
PhenindioneIbuprofen may increase the anticoagulant activities of Phenindione.
PhenprocoumonIbuprofen may increase the anticoagulant activities of Phenprocoumon.
PorfimerIbuprofen may increase the photosensitizing activities of Porfimer.
PralatrexateThe serum concentration of Pralatrexate can be increased when it is combined with Ibuprofen.
ProbenecidThe serum concentration of Ibuprofen can be increased when it is combined with Probenecid.
ReteplaseIbuprofen may increase the anticoagulant activities of Reteplase.
RibostamycinIbuprofen may decrease the excretion rate of Ribostamycin which could result in a lower serum level and potentially a reduction in efficacy.
RidogrelIbuprofen may increase the anticoagulant activities of Ridogrel.
RivaroxabanIbuprofen may increase the anticoagulant activities of Rivaroxaban.
SparfloxacinIbuprofen may increase the neuroexcitatory activities of Sparfloxacin.
SpectinomycinIbuprofen may decrease the excretion rate of Spectinomycin which could result in a lower serum level and potentially a reduction in efficacy.
StreptokinaseIbuprofen may increase the anticoagulant activities of Streptokinase.
StreptomycinIbuprofen may decrease the excretion rate of Streptomycin which could result in a lower serum level and potentially a reduction in efficacy.
SulodexideIbuprofen may increase the anticoagulant activities of Sulodexide.
TacrolimusIbuprofen may increase the nephrotoxic activities of Tacrolimus.
TalniflumateThe risk or severity of adverse effects can be increased when Talniflumate is combined with Ibuprofen.
TenecteplaseIbuprofen may increase the anticoagulant activities of Tenecteplase.
TenofovirThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Tenofovir.
TipranavirTipranavir may increase the antiplatelet activities of Ibuprofen.
TobramycinIbuprofen may decrease the excretion rate of Tobramycin which could result in a lower serum level and potentially a reduction in efficacy.
TorasemideIbuprofen may decrease the diuretic activities of Torasemide.
TositumomabThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Tositumomab.
TreprostinilThe risk or severity of adverse effects can be increased when Treprostinil is combined with Ibuprofen.
TriamtereneIbuprofen may decrease the antihypertensive activities of Triamterene.
TrichlormethiazideThe therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Ibuprofen.
UnoprostoneThe therapeutic efficacy of Unoprostone can be decreased when used in combination with Ibuprofen.
UrokinaseIbuprofen may increase the anticoagulant activities of Urokinase.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Ibuprofen.
VancomycinThe serum concentration of Vancomycin can be increased when it is combined with Ibuprofen.
VenlafaxineVenlafaxine may increase the antiplatelet activities of Ibuprofen.
VerteporfinIbuprofen may increase the photosensitizing activities of Verteporfin.
Vitamin EVitamin E may increase the antiplatelet activities of Ibuprofen.
VoriconazoleThe serum concentration of Ibuprofen can be increased when it is combined with Voriconazole.
WarfarinIbuprofen may increase the anticoagulant activities of Warfarin.
Food Interactions
  • Avoid alcohol
  • Food delays the time to reach peak plasma concentrations by 30-60 minutes and reduces peak plasma concentrations by 30-50%. Extent of absorption is unaffected.
  • Take with food to reduce gastric irritation.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, p...
Gene Name:
PTGS2
Uniprot ID:
P35354
Molecular Weight:
68995.625 Da
References
  1. Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. [PubMed:12852704 ]
  2. Ouellet M, Falgueyret JP, Percival MD: Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms. Biochem J. 2004 Feb 1;377(Pt 3):675-84. [PubMed:14510637 ]
  3. Gallego-Sandin S, Novalbos J, Rosado A, Gisbert JP, Galvez-Mugica MA, Garcia AG, Pajares JM, Abad-Santos F: Effect of ibuprofen on cyclooxygenase and nitric oxide synthase of gastric mucosa: correlation with endoscopic lesions and adverse reactions. Dig Dis Sci. 2004 Sep;49(9):1538-44. [PubMed:15481334 ]
  4. Murphey LJ, Williams MK, Sanchez SC, Byrne LM, Csiki I, Oates JA, Johnson DH, Morrow JD: Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Anal Biochem. 2004 Nov 15;334(2):266-75. [PubMed:15494133 ]
  5. Sanchez-Fidalgo S, Martin-Lacave I, Illanes M, Motilva V: Angiogenesis, cell proliferation and apoptosis in gastric ulcer healing. Effect of a selective cox-2 inhibitor. Eur J Pharmacol. 2004 Nov 28;505(1-3):187-94. [PubMed:15556152 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Chavez ML, DeKorte CJ: Valdecoxib: a review. Clin Ther. 2003 Mar;25(3):817-51. [PubMed:12852704 ]
  2. Patrignani P: Aspirin insensitive eicosanoid biosynthesis in cardiovascular disease. Thromb Res. 2003 Jun 15;110(5-6):281-6. [PubMed:14592549 ]
  3. Gupta K, Kaub CJ, Carey KN, Casillas EG, Selinsky BS, Loll PJ: Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors. Bioorg Med Chem Lett. 2004 Feb 9;14(3):667-71. [PubMed:14741265 ]
  4. Martic M, Tatic I, Markovic S, Kujundzic N, Kostrun S: Synthesis, biological activity and molecular modeling studies of novel COX-1 inhibitors. Eur J Med Chem. 2004 Feb;39(2):141-51. [PubMed:14987823 ]
  5. Hillarp A: [Acetylsalicylic acid resistance--clinical diagnosis with unclear mechanism]. Lakartidningen. 2004 Nov 4;101(45):3504-6, 3508-9. [PubMed:15575422 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. [PubMed:23536207 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
modulator
General Function:
Ubiquitin protein ligase binding
Specific Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating f...
Gene Name:
BCL2
Uniprot ID:
P10415
Molecular Weight:
26265.66 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
modulator
General Function:
Transmembrane signaling receptor activity
Specific Function:
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Gene Name:
THBD
Uniprot ID:
P07204
Molecular Weight:
60328.72 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
negative modulator
General Function:
Serine-type endopeptidase activity
Specific Function:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Gene Name:
PLAT
Uniprot ID:
P00750
Molecular Weight:
62916.495 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
binder
General Function:
Transporter activity
Specific Function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Gene Name:
FABP2
Uniprot ID:
P12104
Molecular Weight:
15207.165 Da
References
  1. Velkov T, Chuang S, Wielens J, Sakellaris H, Charman WN, Porter CJ, Scanlon MJ: The interaction of lipophilic drugs with intestinal fatty acid-binding protein. J Biol Chem. 2005 May 6;280(18):17769-76. Epub 2005 Feb 18. [PubMed:15722357 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
activator
General Function:
Zinc ion binding
Specific Function:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation...
Gene Name:
PPARG
Uniprot ID:
P37231
Molecular Weight:
57619.58 Da
References
  1. Dill J, Patel AR, Yang XL, Bachoo R, Powell CM, Li S: A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons. J Neurosci. 2010 Jan 20;30(3):963-72. doi: 10.1523/JNEUROSCI.5045-09.2010. [PubMed:20089905 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Pdz domain binding
Specific Function:
Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Gene Name:
CFTR
Uniprot ID:
P13569
Molecular Weight:
168139.895 Da
References
  1. Devor DC, Schultz BD: Ibuprofen inhibits cystic fibrosis transmembrane conductance regulator-mediated Cl- secretion. J Clin Invest. 1998 Aug 15;102(4):679-87. [PubMed:9710435 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. [PubMed:20167001 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  4. Carlile DJ, Hakooz N, Bayliss MK, Houston JB: Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans. Br J Clin Pharmacol. 1999 Jun;47(6):625-35. [PubMed:10383540 ]
  5. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Yu L, Shi D, Ma L, Zhou Q, Zeng S: Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. doi: 10.1002/bdd.1842. Epub 2013 Jun 3. [PubMed:23536207 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naph...
Gene Name:
UGT1A1
Uniprot ID:
P22309
Molecular Weight:
59590.91 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A3
Uniprot ID:
P35503
Molecular Weight:
60337.835 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Retinoic acid binding
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Gene Name:
UGT1A9
Uniprot ID:
O60656
Molecular Weight:
59940.495 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydr...
Gene Name:
UGT2B4
Uniprot ID:
P06133
Molecular Weight:
60512.035 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Glucuronosyltransferase activity
Specific Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol suggests it may play an important role in regulating the level and activity of these potent and active estrogen metabolites. Is also active with androsterone, hyodeoxycholic acid and tetrachlorocatechol...
Gene Name:
UGT2B7
Uniprot ID:
P16662
Molecular Weight:
60694.12 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the gener...
Gene Name:
PTGS1
Uniprot ID:
P23219
Molecular Weight:
68685.82 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Prostaglandin-endoperoxide synthase activity
Specific Function:
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, p...
Gene Name:
PTGS2
Uniprot ID:
P35354
Molecular Weight:
68995.625 Da
References
  1. Palayoor ST, J-Aryankalayil M, Makinde AY, Cerna D, Falduto MT, Magnuson SR, Coleman CN: Gene expression profile of coronary artery cells treated with nonsteroidal anti-inflammatory drugs reveals off-target effects. J Cardiovasc Pharmacol. 2012 Jun;59(6):487-99. doi: 10.1097/FJC.0b013e31824ba6b5. [PubMed:22668799 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Yamasaki K, Rahman MH, Tsutsumi Y, Maruyama T, Ahmed S, Kragh-Hansen U, Otagiri M: Circular dichroism simulation shows a site-II-to-site-I displacement of human serum albumin-bound diclofenac by ibuprofen. AAPS PharmSciTech. 2000 May 14;1(2):E12. [PubMed:14727845 ]
  2. Galantini L, Leggio C, Konarev PV, Pavel NV: Human serum albumin binding ibuprofen: a 3D description of the unfolding pathway in urea. Biophys Chem. 2010 Apr;147(3):111-22. doi: 10.1016/j.bpc.2010.01.002. Epub 2010 Jan 18. [PubMed:20117876 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
Gene Name:
SLCO2B1
Uniprot ID:
O94956
Molecular Weight:
76709.98 Da
References
  1. Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. [PubMed:15640378 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. [PubMed:12954186 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Atpase activity, coupled to transmembrane movement of substances
Specific Function:
May be an organic anion pump relevant to cellular detoxification.
Gene Name:
ABCC4
Uniprot ID:
O15439
Molecular Weight:
149525.33 Da
References
  1. Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. [PubMed:12835412 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Molecular Weight:
171589.5 Da
References
  1. Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. [PubMed:12835412 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. [PubMed:10991954 ]
  2. Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. [PubMed:12130730 ]
  3. Uwai Y, Saito H, Inui K: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 2000 Dec 1;409(1):31-6. [PubMed:11099697 ]
  4. Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. [PubMed:10220563 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. [PubMed:11306713 ]
  2. Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. [PubMed:12130730 ]
  3. Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. [PubMed:15100168 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
Gene Name:
SLC22A11
Uniprot ID:
Q9NSA0
Molecular Weight:
59970.945 Da
References
  1. Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. [PubMed:12130730 ]
  2. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. [PubMed:10660625 ]
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Drug created on June 13, 2005 07:24 / Updated on August 24, 2016 02:48