You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameTolnaftate
Accession NumberDB00525  (APRD01607)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete’s foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters.

Structure
Thumb
Synonyms
2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate
m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester
N-Methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
O-2-Naphthyl m,N-dimethylthiocarbanilate
Separin
Tinactin
Tolnaftato
Tolnaftatum
Tolnaphthate
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Absorbine Antifungal Powder 1%powder1 %topicalW.F. Young, Inc.1992-12-311997-07-28Canada
Absorbine Jr Antifungal Liquidliquid10 mgtopicalClarion Brands Llc1999-08-18Not applicableCanada
Anti-fungalpowder.45 g/45gtopicalRij Pharmaceutical Corporation1999-03-16Not applicableUs
Anti-fungalpowder1 g/100gtopicalRugby Laboratories2011-11-01Not applicableUs
Antifungalcream10 mg/gtopicalUnifirst First Aid Corporation2002-06-30Not applicableUs
Antifungalsolution1 mg/100mLtopicalPerrigo New York Inc2011-08-17Not applicableUs
Antifungalcream10 mg/gtopicalMoore Medical LLC2012-07-16Not applicableUs
Antifungalsolution1 mg/100mLtopicalPerrigo New York Inc2005-12-06Not applicableUs
Antifungalcream1 g/100gtopicalRite Aid Corporation2005-07-23Not applicableUs
Antifungal Creamcream1 %topicalPharmetics (2011) IncNot applicableNot applicableCanada
Antifungal Foot Carespray1 g/100gtopicalRite Aid Corporation2004-09-24Not applicableUs
Athlete's Foot Gel 1%gel1 %topicalSchering Plough Canada Inc1982-12-312012-07-24Canada
Athlete's Foot Spray Powerspray1 %topicalEmpack Spraytech IncNot applicableNot applicableCanada
Athletes Footcream1 g/100gtopicalCVS Pharmacy2005-06-09Not applicableUs
Athletes Footspray1 g/100gtopicalDOLGENCORP, LLC.2014-11-04Not applicableUs
Athletes Footspray1 g/100gtopicalWalgreen Company2004-09-10Not applicableUs
Athletes Footcream1 g/100gtopicalKroger Company2012-01-26Not applicableUs
Athletes Footspray1 g/100gtopicalMeijer Distribution Inc2004-10-26Not applicableUs
Athletes Footspray1 g/100gtopicalTaizhou Ludao Cosmetics Co., Ltd.2014-11-04Not applicableUs
Athletes Footspray1 g/100gtopicalMeijer Distribution Inc2004-10-26Not applicableUs
Athletes Foot Medicated Antifungalspray1 g/100gtopicalWalgreen Company2004-09-10Not applicableUs
Athletes Foot Spray Dr. Footaerosol1 g/100gtopicalBlue Cross Laboratories2010-10-19Not applicableUs
Atopalm Tolnaftate Antifungalcream1 g/100gtopicalNeoPharm Co., Ltd.2011-03-16Not applicableUs
Avon Foot Works Therapeutic Antifungal Foot Creamcream1 %topicalAvon Canada Ulc2004-03-012011-08-05Canada
Avon Footworks Antifungal and Deodorant Powderpowder1 %topicalAvon Canada Ulc1998-07-162006-01-27Canada
Avon Footworks Antifungal Foot Sprayliquid1 %topicalAvon Canada Ulc1998-07-162012-07-25Canada
Barielle Fungus Rx Maximum Strength Anti-fungalsolution1 mL/100mLtopicalFisk Industries2012-01-01Not applicableUs
Barielle Professional Maximum Strength Fungus Rx Antifungal Prosolution1 mL/100mLtopicalFisk Industries2012-01-01Not applicableUs
Bengama Antifungalsolution1 mg/100mLtopicalGenuine Drugs2015-04-20Not applicableUs
Bio-scriptives Extreme AFcream.56 g/56.69gtopicalBio Chemics, Inc.2011-07-27Not applicableUs
Blistex Odor-eaters Powderspray1 g/100gtopicalBlistex Inc2013-12-09Not applicableUs
Canesten Powderpowder1 %topicalBayer Inc Consumer CareNot applicableNot applicableCanada
Careall Tolnaftatecream10 mg/gtopicalNew World Imports, Inc2012-06-01Not applicableUs
Cidacin Antifungal Treatmentsolution1 mL/100mLtopicalPedicis Research LLC2012-06-07Not applicableUs
Clarus Antifungalcream1 g/100gtopicalClinical Therapeutic Solutions2012-06-07Not applicableUs
Clarus Antifungalsolution1 mL/100mLtopicalClinical Therapeutic Solutions2012-06-07Not applicableUs
Cvs Athletes Foot Cream .5ozcream10 mg/gtopicalCVS Pharmacy, Inc.2014-10-13Not applicableUs
Cvs Athletes Foot Tolnaftatecream10 mg/gtopicalCVS Pharmacy2014-10-10Not applicableUs
Dg Athletes Footcream10 mg/gtopicalTAI GUK PHARM. CO., LTD.2010-12-10Not applicableUs
Dg Health Athletes Footcream10 mg/gtopicalDolgencorp, LLC2015-11-05Not applicableUs
Dr Canuso Fungal Nail Eraseroil.14 g/14gtopicalRenu Laboratories, Inc.2015-08-11Not applicableUs
Dr. Canuso Foot Repair Serumlotion.3 g/28gtopicalRenu Laboratories, Inc.2015-08-20Not applicableUs
Dr. Gs Clear Nailliquid10 mg/mLtopicalPacific World Corporation2013-04-24Not applicableUs
Dr. Scholl's Athlete's Foot Powder - 1%powder1 %topicalSchering Plough Canada Inc1997-01-212012-07-24Canada
Dr. Scholl's Athlete's Foot Spray Powderaerosol; powder1 %topicalBayer Inc Consumer Care1989-12-31Not applicableCanada
Dr. Scholls Odor-X Foot and Sneakeraerosol, powder10 mg/gtopicalMSD Consumer Care, Inc.1993-09-23Not applicableUs
Equaline Athletes Footspray1 g/100gtopicalSupervalu Inc2004-09-11Not applicableUs
Equaline Athletes Footspray1 g/100gtopicalSupervalu Inc2004-09-11Not applicableUs
Equaline Tolnaftate Antifungalcream10 mg/gtopicalSupervalu Inc2011-09-28Not applicableUs
Equate Athletes Footspray1 g/100gtopicalWal Mart Stores Inc2004-09-07Not applicableUs
Equate Athletes Footcream10 mg/gtopicalWal Mart Stores Inc2006-02-17Not applicableUs
Equate Athletes Foot Powderspray1 g/100gtopicalWal Mart Stores Inc2004-09-29Not applicableUs
Equate Liquid Footspray1 g/150gtopicalWal Mart Stores, Inc2014-07-01Not applicableUs
Equate Liquid Footspray1 g/150gtopicalTaizhou Ludao Cosmetics Co., Ltd.2014-07-01Not applicableUs
Ez Clearcream1 %topicalPromotion Eco St Clair Inc.Not applicableNot applicableCanada
Family Care Tolnaftatecream10 mg/gtopicalUNITED EXCHANGE CORP.2013-04-30Not applicableUs
Family Wellness Antifungalcream1 g/100gtopicalFamily Dollar2014-01-21Not applicableUs
Family Wellness Antifungalcream1 g/100gtopicalFamily Dollar2014-01-21Not applicableUs
First Aid Antifungal Medicated Cream 0.5 Ozcream10 mg/gtopicalFirst Aid Reserach Corp2014-10-09Not applicableUs
First Aid Antifungal Medicated Cream 1ozcream10 mg/gtopicalFirst Aid Reserach Corp2014-10-09Not applicableUs
Flexitol Medicated Anti-fungal Creamcream1 %topicalLacorium Health International Pty Ltd.2008-09-12Not applicableCanada
Flexitol Medicated Footcream1 g/100gtopicalLa Corium Health International Pty Ltd2012-08-11Not applicableUs
Foot Care Foamaerosol, foam1 %topicalNeubourg Skin Care Of North America Inc2015-09-30Not applicableCanada
Foot Works Healthy Antifungalspray10 mg/mLtopicalNew Avon Llc2011-12-19Not applicableUs
Foot Works Healthy Antifungalpowder10 mg/gtopicalNew Avon Llc2013-04-24Not applicableUs
Footlogix Anti Fungal Mousse Formulaaerosol1 %topicalKVG Group IncNot applicableNot applicableCanada
Footshield Pluscream1 g/100gtopicalQ.A. Laboratories2012-02-01Not applicableUs
Footworks Healthy Antifungal Powder for Athlete's Footpowder1 %topicalAvon Canada Ulc2013-06-24Not applicableCanada
Footworks Healthy Antifungal Spray for Athlete's Footspray1 %topicalAvon Canada Ulc2012-02-29Not applicableCanada
Formucare Athletes Foot Maximum Strengthspray1 g/100gtopicalAccess Business Group LLC2004-11-11Not applicableUs
Formula 3solution10 mg/mLtopicalThe Tetra Corporation2012-10-30Not applicableUs
Formula 3solution1 %topicalThe Tetra Corporation2014-01-16Not applicableCanada
Fulton Street Market Athletes Footcream1 g/100gtopicalAccess Business Group LLC2009-08-14Not applicableUs
Fungablend 10liquid10 mg/mLtopicalHappy Foot Shop, Llc2015-07-09Not applicableUs
Fungicuregel10 mg/gtopicalAlva Amco Pharmacal Companies, Inc.1994-10-01Not applicableUs
Fungicure Anti-fungal Pump Sprayliquid1 %topicalAlva Amco Pharmacal Companies, Inc.2002-01-192005-07-22Canada
Fungicure Athlete's Foot Creamcream1 %topicalAlva Amco Pharmacal Companies, Inc.Not applicableNot applicableCanada
Fungicure Athletes Footcream10 mg/gtopicalAlva Amco Pharmacal Companies, Inc2014-03-26Not applicableUs
Fungicure Gelgel1 %topicalAlva Amco Pharmacal Companies, Inc.1999-05-11Not applicableCanada
Fungifoamaerosol, foam10 mg/mLtopicalThe Tetra Corporation2012-10-31Not applicableUs
Fungoid-Dcream1 g/100gtopicalPedinol Pharmacal, Inc.2011-08-01Not applicableUs
Fungus Mdliquid1 g/100mLtopicalOrly International Inc2014-07-18Not applicableUs
Fungus Reliefsolution10 mg/mLtopicalSwabplus Inc.2003-03-01Not applicableUs
Gadaderm Antifungalcream1 g/100gtopicalGadal Laboratories Inc2013-01-01Not applicableUs
Good Sense Athletes Footspray1 g/100gtopicalL Perrigo Company2005-06-14Not applicableUs
Good Sense Jock Itchspray1 g/100gtopicalL Perrigo Company2005-06-15Not applicableUs
Healthy Accents Athletes Foot Antifungalcream1 g/100gtopicalDZA Brands LLC2010-07-21Not applicableUs
Hi Veticointment1 g/100gtopicalSato Pharmaceutical Co., Ltd.1996-10-25Not applicableUs
Hi Veticsolution1 g/100mLtopicalSato Pharmaceutical Co., Ltd.1990-08-14Not applicableUs
Homehealth Antifungallotion1 mL/100mLtopicalHome Health2011-02-14Not applicableUs
Hongo Killerpowder1 g/100gtopicalEfficient Laboratories Inc2000-01-01Not applicableUs
Hongo Killeraerosol, powder.1 g/10gtopicalEfficient Laboratories Inc2002-03-01Not applicableUs
Hongo Killer Antifungalcream.1 g/10gtopicalEfficient Laboratories Inc2000-01-01Not applicableUs
Hongo Killer Antifungalcream.1 g/10gtopicalEfficient Laboratories Inc2000-01-01Not applicableUs
Jock Itchspray1 g/100gtopicalRite Aid Corporation2004-10-12Not applicableUs
Jock Itchspray1 g/100gtopicalWalgreen Company2005-06-08Not applicableUs
Kaiser Permanente Tolnaftatecream10 mg/gtopicalKaiser Foundations Hospitals2006-02-17Not applicableUs
Keractil Plusgel10 mg/gtopicalPolimeros Y Servicios S.A.2016-03-09Not applicableUs
Kiss Fungi-gone Anti-fungal Treatmentliquid10 mg/mLtopicalKiss Products, Inc.2012-10-23Not applicableUs
Lamisl AF Defenseaerosol, spray10 mg/gtopicalNovartis Consumer Health, Inc.2006-02-01Not applicableUs
Lamisl AF Defensecream10 mg/gtopicalNovartis Consumer Health, Inc.2010-01-01Not applicableUs
Leader Antifungal Tolnaftatecream10 mg/gtopicalCardinal Health2012-03-01Not applicableUs
Leader Medicatedaerosol, powder10 mg/gtopicalCardinal Health Inc.2008-03-15Not applicableUs
Meijer Antifungalcream10 mg/gtopicalMeijer Distribution Inc2006-02-17Not applicableUs
Meijer Tolnaftatecream10 mg/gtopicalMEIJER, INC.2015-01-19Not applicableUs
Miracle Plus Anti-fungalcream.59 g/59gtopicalConcept Laboratories, Inc.2011-01-04Not applicableUs
Miracle Plus Anti-fungal Foot Reliefcream.01 g/gtopicalConcept Laboratories, Inc.2015-07-02Not applicableUs
Molecular AFoil.01 mg/mLtopicalRenu Laboratories, Inc.2011-07-01Not applicableUs
Nail Active Daytime Anti-fungallotion100 g/gtopicalHarvest Trading Group Inc.2014-03-17Not applicableUs
Nail Renewliquid1 g/100mLtopicalNail Renew2014-03-22Not applicableUs
Nailene Antifungal Treatmentliquid10 mg/mLtopicalPacific World Corporation2013-04-24Not applicableUs
Odor Eaters Foot and Sneakerspray10 mg/gtopicalCombe Incorporated2001-09-01Not applicableUs
Odor-eatersaerosol1 %topicalBlistex Corporation2002-03-07Not applicableCanada
Ongo - Finliquid1 mL/100mLtopicalEfficient Laboratories Inc.2004-02-01Not applicableUs
Personal Care Antifungalspray1 g/100gtopicalPersonal Care Products, Inc.2010-05-21Not applicableUs
Pitrex Crm 1%cream1 %topicalTaro Pharmaceuticals Inc1979-12-31Not applicableCanada
Premier Value Tolnaftate Antifungalcream10 mg/gtopicalChain Drug Consortium, LLC2012-01-20Not applicableUs
Proclearz Anti-fungal Pensolution1 %topicalProfoot Inc.Not applicableNot applicableCanada
Proclearz Antifungal Liquidliquid1 %topicalProfoot Inc.1998-10-09Not applicableCanada
Proclearz Fungi-cide PMcream1 g/100gtopicalProfoot, Inc.2012-10-10Not applicableUs
Proclearz Maximum Strength Anti-fungal Penliquid10 mg/mLtopicalProfoot, Inc.2012-10-23Not applicableUs
Proclearz Maximum Strength Fungal Shield Brush-ON Antifungalsolution10 mg/mLtopicalProfoot, Inc.2012-10-22Not applicableUs
Quality Choice Tolnaftate Antifungalcream1 g/100gtopicalChain Drug Marketing Association Inc2013-05-31Not applicableUs
Sanafitilcream1 g/100gtopicalPromex LLC2015-01-07Not applicableUs
Sanafitil Cremacream1 g/100gtopicalPromex LLC2015-01-07Not applicableUs
Signature Black Bottle Tea Tree Antifungal Foot and Body Washlotion10 mg/mLtopicalRestoration Rockstar, Llc (Dba: Kroning Signature Black Bottle)2016-02-10Not applicableUs
Signature Care Antifungalcream10 mg/gtopicalBetter Living Brands Llc2015-08-26Not applicableUs
Signature Care Athletes Footspray1 g/100gtopicalSafeway2015-11-23Not applicableUs
Signature Care Athletes Footspray1 g/100gtopicalSafeway2015-10-11Not applicableUs
Smart Sense Athletes Footspray1 g/100gtopicalKmart Corporation2011-04-21Not applicableUs
Smart Sense Athletes Foot Reliefspray1 g/100gtopicalKmart Corporation2016-04-12Not applicableUs
Smart Sense Tolnaftate Antifungalcream10 mg/gtopicalKmart Corporation2014-09-23Not applicableUs
Smart Sense Tolnftate Antifungalcream10 mg/gtopicalKmart Corporation2011-11-14Not applicableUs
Snap Stiks Athlete's Foot Relief Swabs With Tolnaftateswab1 %topicalAms Homecare Inc.Not applicableNot applicableCanada
Snap-stiks Senior's Foot Fungus Relief Swabs With Tolnaftateswab1 %topicalAms Homecare Inc.Not applicableNot applicableCanada
Soundbody Tolnaftate Antifungalcream10 mg/gtopicalUNITED EXCHANGE CORP.2014-02-26Not applicableUs
Sunmark Antifungalcream10 mg/gtopicalMc Kesson2006-02-17Not applicableUs
Sunmark Athletes Foot Liquid Sprayspray1 g/100gtopicalMc Kesson2005-06-16Not applicableUs
Sunmark Athletes Foot Powderspray1 g/100gtopicalMc Kesson2005-06-16Not applicableUs
Swabplus Athlete's Foot Relief Swabs With Tolnaftateswab1 %topicalSwabplus Canada Inc.2003-06-152008-09-22Canada
Swabplus Fungus Relief Swabs With Tolnaftateswab1 %topicalSwabplus Canada Inc.2003-06-152008-09-22Canada
Target Antifungalcream10 mg/gtopicalTarget Corporation2006-02-17Not applicableUs
Tinactincream10 mg/gtopicalBayer Health Care Llc1993-09-23Not applicableUs
Tinactincream1 %topicalBayer Inc Consumer Care1965-12-31Not applicableCanada
Tinactincream10 mg/gtopicalBayer Health Care Llc1993-09-23Not applicableUs
Tinactinaerosol, powder10 mg/gtopicalMSD Consumer Care, Inc.1993-09-23Not applicableUs
Tinactinpowder10 mg/gtopicalMSD Consumer Care, Inc.1993-09-23Not applicableUs
Tinactinaerosol, spray10 mg/gtopicalMSD Consumer Care, Inc.1993-09-23Not applicableUs
Tinactinaerosol, powder10 mg/gtopicalMSD Consumer Care, Inc.1993-09-23Not applicableUs
Tinactin Aerosol Powderaerosol1 %topicalBayer Inc Consumer Care1983-12-31Not applicableCanada
Tinactin Antifungalaerosol, powder10 mg/gtopicalMSD Consumer Care, Inc.2014-02-28Not applicableUs
Tinactin Antifungalaerosol, powder10 mg/gtopicalMSD Consumer Care, Inc.2011-10-01Not applicableUs
Tinactin Chill Deodorant Powder Sprayaerosol1 %topicalBayer Inc Consumer Care2009-07-18Not applicableCanada
Tinactin Chill Liquid Sprayaerosol1 %topicalBayer Inc Consumer Care2009-07-15Not applicableCanada
Tinactin Jock Itch Crm 10mg/gmcream10 mgtopicalSchering Plough Canada Inc1984-12-312006-08-01Canada
Tinactin Jock Itch Top Aer Pwr 10mg/gmpowder10 mgtopicalSchering Plough Canada Inc1984-12-312001-07-18Canada
Tinactin Liquid Aerosol 0.72mg/gmaerosol.72 mgtopicalSchering Plough Canada Inc1985-12-312001-07-18Canada
Tinactin Plus Areosol Powder 1%aerosol1 %topicalSchering Plough Canada Inc1992-12-312001-07-18Canada
Tinactin Plus Powder 1%powder1 %topicalSchering Plough Canada Inc1993-12-312001-07-18Canada
Tinactin Powderpowder1 %topicalBayer Inc Consumer Care1965-12-31Not applicableCanada
Tinactin Pump Sprayspray1 %topicalSchering Plough Canada Inc2001-05-012013-07-31Canada
Tinactin Sol 10mg/mlliquid10 mgtopicalSchering Plough Canada Inc1964-12-312007-08-03Canada
Tinactin Super Absorbentpowder10 mg/gtopicalBayer Health Care Llc2015-03-01Not applicableUs
Tineacideliquid140 mg/15mLtopicalBlaine Labs Inc.2012-09-19Not applicableUs
Tingaerosol, spray1.28 g/128gtopicalInsight Pharmaceuticals2009-07-27Not applicableUs
Tingcream100 mg/gtopicalInsight Pharmaceuticals2009-06-08Not applicableUs
Tolnafateaerosol, spray1.3 g/113gtopicalCVS Pharmacy2014-01-01Not applicableUs
Tolnaftateaerosol, spray1.13 g/113gtopicalTopco Associates LLC2012-01-05Not applicableUs
Tolnaftateaerosol, powder1.1 g/113.3gtopicalTarget Corporation2008-12-31Not applicableUs
Tolnaftateaerosol, powder1.3 g/130gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Tolnaftateaerosol, spray1.3 g/113gtopicalHarmon Store Inc.2012-01-27Not applicableUs
Tolnaftatecream1 g/100gtopicalDiscount Drug Mart, Inc.2015-11-09Not applicableUs
Tolnaftateaerosol, spray.15 g/150gtopicalChain Drug Consortium, LLC2003-05-23Not applicableUs
Tolnaftateaerosol, spray1.5 g/150.2gtopicalTarget Corporation2008-12-31Not applicableUs
Tolnaftateaerosol, spray1.3 g/130gtopicalTopco Associates LLC2012-01-03Not applicableUs
Tolnaftatecream10 mg/gtopicalA S Medication Solutions Llc2010-02-11Not applicableUs
Tolnaftateaerosol, spray.13 g/130gtopicalChain Drug Consortium, LLC2003-05-23Not applicableUs
Tolnaftatecream10 mg/gtopicalMajor Pharmaceuticals2010-02-11Not applicableUs
Tolnaftatecream10 mg/gtopicalFaria Limited dba Sheffield Pharmaceuticals2009-10-07Not applicableUs
Tolnaftateaerosol, spray1.5 g/150gtopicalTopco Associates LLC2012-01-03Not applicableUs
Tolnaftatecream1 g/100gtopicalMorales Distributors, Inc.2012-09-25Not applicableUs
Tolnaftatepowder1 g/100gtopicalPerrigo New York Inc2005-12-07Not applicableUs
Tolnaftateaerosol, spray1.3 g/113gtopicalChain Drug Consortium, LLC2006-06-01Not applicableUs
Tolnaftatecream1 g/100gtopicalNavarro Discount Pharmacies,LLC2012-08-01Not applicableUs
Tolnaftatecream1 %topicalNexmed Usa IncNot applicableNot applicableCanada
Tolnaftatespray1.5 g/150gtopicalWalgreens Company2009-03-11Not applicableUs
Tolnaftatecream1 g/100gtopicalNeo Pharm Co., Ltd.2010-08-27Not applicableUs
Tolnaftateaerosol, spray.13 g/130gtopicalChain Drug Consortium, LLC2004-04-23Not applicableUs
Tolnaftateaerosol, spray1.5 g/150gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Tolnaftateaerosol, powder1.3 g/130gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Tolnaftateaerosol, powder1.3 g/130gtopicalCVS Pharmacy2014-01-04Not applicableUs
Tolnaftatecream1 g/100gtopicalPerrigo New York Inc2011-08-02Not applicableUs
Tolnaftateaerosol, spray1.3 g/113gtopicalWalgreen Company2012-01-20Not applicableUs
Tolnaftatecream1 g/100gtopicalTaro Pharmaceuticals, Inc.2009-08-20Not applicableUs
Tolnaftateaerosol, spray1.3 g/130gtopicalTopco Associates LLC2012-01-03Not applicableUs
Tolnaftatecream10 mg/gtopicalLif Elabs, A Division Of Atico International, Usa, Inc.2010-11-01Not applicableUs
Tolnaftateaerosol, spray1.5 g/150gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Tolnaftateaerosol, spray1.5 g/150gtopicalHarmon Store Inc.2012-02-14Not applicableUs
Tolnaftateaerosol, powder1.3 g/130gtopicalFamily Dollar Services Inc.2013-01-10Not applicableUs
Tolnaftateaerosol, powder1.3 g/113gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Tolnaftateaerosol, spray1.5 g/150gtopicalCVS Pharmacy2014-01-01Not applicableUs
Tolnaftatecream1 g/100gtopicalValu Merchandisers, Co.2012-03-01Not applicableUs
Tolnaftatecream1 g/100gtopicalKareway Product, Inc.2011-08-11Not applicableUs
Tolnaftate Antifungalcream10 mg/gtopicalAmerisource Bergen2006-02-17Not applicableUs
Tolnaftate Antifungalcream1 g/100gtopicalTaro Pharmaceuticals U.S.A., Inc.1995-01-01Not applicableUs
Tolnaftate Antifungalpowder1 g/100gtopicalGeri Care Pharmaceuticals, Corp2011-08-01Not applicableUs
Tolnaftate Antifungalpowder1 g/100gtopicalMajor Pharmaceuticals2011-11-01Not applicableUs
Tolnaftate Antifungal Creamcream1 %topicalG&W Laboratories Inc.2005-11-302011-08-22Canada
Tolnaftate Cream 1% Antifungalcream1 g/100gtopicalTrifecta Pharmaceuticals Usa Llc2016-04-09Not applicableUs
Tolnaftate Cream USP 1% for Athlete's Footcream1.0 %topicalCrlsNot applicableNot applicableCanada
Tolnaftate Cream USP, 1%cream1 %topicalTaro Pharmaceuticals Inc2010-03-10Not applicableCanada
Tolnaftate Dcream1 g/100gtopicalNex Med (Usa), Inc.2011-08-15Not applicableUs
Topcare Tolnaftate Antifungalcream10 mg/gtopicalTopco Associates LLC2006-02-17Not applicableUs
Walgreens Tolnaftatecream10 mg/gtopicalWalgreen Company2011-05-04Not applicableUs
Western Family Antifungalcream10 mg/gtopicalWestern Family Foods Inc2006-02-17Not applicableUs
Wick Storm Tea Tree Antifungal Foot Body Washliquid10 mg/mLtopicalRestoration Rockstar Llc2015-07-10Not applicableUs
Winco Foods Tolnaftatecream10 mg/gtopicalWinCo Foods, LLC2015-02-06Not applicableUs
Woodwards Mycocide Clinical NSliquid10 mg/mLtopicalPacific World Corporation2013-04-24Not applicableUs
Xtracare Antifungal Footspray1 g/100gtopicalTaizhou Ludao Cosmetics Co., Ltd.2014-02-11Not applicableUs
Xtracare Antifungal Footspray1 g/100gtopicalRejoice International2014-02-11Not applicableUs
Zeasorb AFpowder1 %topicalGlaxosmithkline Inc1994-12-312014-02-20Canada
Unapproved/Other Products Not Available
International Brands
NameCompany
AftateNot Available
Dr. Scholl's athlete's foot sprayNot Available
GenasporNot Available
Lamisil AFNot Available
NP-27Not Available
Odor EatersNot Available
PitrexNot Available
SeparinNot Available
TinadermNot Available
Brand mixtures
NameLabellerIngredients
Absorbine Jr Antifungal LiqClarion Brands Llc
HeeltasticNeutraderm, Inc.
Nail MdOmg Medical Group, Llc
SaltsNot Available
Categories
UNII06KB629TKV
CAS number2398-96-1
WeightAverage: 307.409
Monoisotopic: 307.103084861
Chemical FormulaC19H17NOS
InChI KeyInChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N
InChI
InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3
IUPAC Name
N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
SMILES
CN(C(=S)OC1=CC2=CC=CC=C2C=C1)C1=CC=CC(C)=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
KingdomOrganic compounds
Super ClassBenzenoids
ClassNaphthalenes
Sub ClassNot Available
Direct ParentNaphthalenes
Alternative Parents
Substituents
  • Naphthalene
  • Aminotoluene
  • Toluene
  • Monocyclic benzene moiety
  • Thiocarbamic acid ester
  • Thiocarbamic acid derivative
  • Tertiary amine
  • Thiocarbonic acid derivative
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationTolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
PharmacodynamicsTolnaftate is a synthetic over-the-counter anti-fungal agent.
Mechanism of actionTolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityOral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Affected organisms
  • Yeast and other fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9904
Blood Brain Barrier+0.9689
Caco-2 permeable+0.6348
P-glycoprotein substrateNon-substrate0.8667
P-glycoprotein inhibitor INon-inhibitor0.5537
P-glycoprotein inhibitor IINon-inhibitor0.857
Renal organic cation transporterNon-inhibitor0.8281
CYP450 2C9 substrateNon-substrate0.7363
CYP450 2D6 substrateNon-substrate0.6071
CYP450 3A4 substrateSubstrate0.6401
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorInhibitor0.8948
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorInhibitor0.8994
CYP450 3A4 inhibitorInhibitor0.7959
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9229
Ames testAMES toxic0.8449
CarcinogenicityNon-carcinogens0.7425
BiodegradationNot ready biodegradable1.0
Rat acute toxicity1.7405 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8836
hERG inhibition (predictor II)Non-inhibitor0.5943
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Liquidtopical
Liquidtopical10 mg
Powdertopical.45 g/45g
Solutiontopical1 mg/100mL
Aerosoltopical1 g/100g
Solutiontopical1 mL/100mL
Creamtopical.56 g/56.69g
Oiltopical.14 g/14g
Lotiontopical.3 g/28g
Aerosol; powdertopical1 %
Spraytopical1 g/150g
Aerosol, foamtopical1 %
Spraytopical10 mg/mL
Spraytopical1 %
Solutiontopical1 %
Solutiontopical10 mg/mL
Geltopical10 mg/g
Geltopical1 %
Aerosol, foamtopical10 mg/mL
Creamtopical1 g/100g
Spraytopical1 g/100g
Sticktopical
Ointmenttopical1 g/100g
Solutiontopical1 g/100mL
Lotiontopical1 mL/100mL
Aerosol, powdertopical.1 g/10g
Creamtopical.1 g/10g
Aerosol, spraytopical10 mg/g
Creamtopical10 mg/g
Creamtopical.59 g/59g
Creamtopical.01 g/g
Oiltopical.01 mg/mL
Lotiontopical100 g/g
Spraytopical
Liquidtopical1 g/100mL
Spraytopical10 mg/g
Liquidtopical1 mL/100mL
Liquidtopical1 %
Liquidtopical10 mg/mL
Lotiontopical10 mg/mL
Swabtopical1 %
Aerosol, powdertopical10 mg/g
Powdertopical10 mg/g
Aerosoltopical1 %
Creamtopical10 mg
Powdertopical10 mg
Aerosoltopical.72 mg
Powdertopical1 %
Liquidtopical140 mg/15mL
Aerosol, spraytopical1.28 g/128g
Creamtopical100 mg/g
Aerosol, spraytopical1.3 g/113g
Aerosol, powdertopical1.1 g/113.3g
Aerosol, powdertopical1.3 g/113g
Aerosol, powdertopical1.3 g/130g
Aerosol, spraytopical.13 g/130g
Aerosol, spraytopical.15 g/150g
Aerosol, spraytopical1.13 g/113g
Aerosol, spraytopical1.3 g/130g
Aerosol, spraytopical1.5 g/150g
Aerosol, spraytopical1.5 g/150.2g
Powdertopical1 g/100g
Spraytopical1.5 g/150g
Creamtopical1.0 %
Creamtopical1 %
Prices
Unit descriptionCostUnit
Zeasorb-AF 2% Powder 70 gm Can14.99USD can
Zeasorb Powder 70.9 gm Can12.99USD can
Tolnaftate powder4.77USD g
Zeasorb-af 2% lotion0.19USD g
Zeasorb powder0.05USD g
Tinactin 1% aerosol0.04USD ml
Athlete's foot 1% liquid spray0.03USD g
Pv antifungal 1% spray liquid0.02USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point111 °CPhysProp
water solubility7.02e-05 mg/mL at 25 °CMEYLAN,WM et al. (1996)
logP5.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000546 mg/mLALOGPS
logP4.87ALOGPS
logP5.75ChemAxon
logS-5.8ALOGPS
pKa (Strongest Basic)0.075ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area12.47 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity94.92 m3·mol-1ChemAxon
Polarizability34.22 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.78 KB)
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-052b-0905000000-19e117da217d372632e2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-00kb-0900000000-a065921efa544c82d972View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0006-9600000000-19faf0e6dcd285dad8d1View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Chris E. Platt, “Topical preparation of tolnaftate and hydrocortisone to treat fungal infections of the skin.” U.S. Patent US5496812, issued November, 1989.

US5496812
General References
  1. Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. [PubMed:8852337 ]
  2. Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. [PubMed:3524433 ]
External Links
ATC CodesD01AE18
AHFS Codes
  • 84:04.08.40
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.2 KB)
Interactions
Drug InteractionsNo interactions found.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Squalene monooxygenase activity
Specific Function:
Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.
Gene Name:
ERG1
Uniprot ID:
Q92206
Molecular Weight:
55297.635 Da
References
  1. Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. [PubMed:8852337 ]
  2. Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. [PubMed:3524433 ]
  3. Georgopapadakou NH, Bertasso A: Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81. [PubMed:1416865 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on September 16, 2013 17:11