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Identification
NameBenazepril
Accession NumberDB00542  (APRD00063)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionBenazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
Structure
Thumb
Synonyms
1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(r*,r*))-
Benazepril
Benazeprilum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Benazepriltablet20 mgoralAa Pharma Inc2006-03-24Not applicableCanada
Benazepriltablet5 mgoralAa Pharma Inc2007-05-15Not applicableCanada
Benazepriltablet10 mgoralAa Pharma Inc2007-05-15Not applicableCanada
Lotensintablet20 mg/1oralPd Rx Pharmaceuticals, Inc.1991-06-25Not applicableUs
Lotensintablet20 mg/1oralNovartis Pharmaceuticals Corporation1991-06-252016-02-01Us
Lotensintablet20 mg/1oralPhysicians Total Care, Inc.1994-03-23Not applicableUs
Lotensintablet40 mg/1oralNovartis Pharmaceuticals Corporation1991-06-252016-01-01Us
Lotensintablet20 mg/1oralValidus Pharmaceuticals LLC1991-06-25Not applicableUs
Lotensintablet40 mg/1oralPhysicians Total Care, Inc.1999-02-24Not applicableUs
Lotensintablet40 mg/1oralValidus Pharmaceuticals LLC1991-06-25Not applicableUs
Lotensintablet5 mg/1oralPhysicians Total Care, Inc.1996-12-30Not applicableUs
Lotensintablet10 mg/1oralPhysicians Total Care, Inc.2003-11-04Not applicableUs
Lotensin 10mgtablet10 mgoralNovartis Pharmaceuticals Canada Inc1993-12-312012-09-11Canada
Lotensin 20mgtablet20 mgoralNovartis Pharmaceuticals Canada Inc1993-12-31Not applicableCanada
Lotensin 5mgtablet5 mgoralNovartis Pharmaceuticals Canada Inc1993-12-31Not applicableCanada
PMS-benazepriltablet5 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-benazepriltablet10 mgoralPharmascience IncNot applicableNot applicableCanada
PMS-benazepriltablet20 mgoralPharmascience IncNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Benazepriltablet20 mg/1oralSTAT Rx USA LLC2010-02-02Not applicableUs
Benazepriltablet, coated40 mg/1oralInternational Laboratories, Inc.2013-09-19Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralRanbaxy Pharmaceuticals Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralPreferred Pharmaceuticals, Inc2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, coated5 mg/1oralSolco healthcare U.S., LLC2014-01-01Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralMylan Pharmaceuticals Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2011-09-29Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralNorthwind Pharmaceuticals2014-05-30Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralApotex Corp2006-04-21Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralCardinal Health2011-08-16Not applicableUs
Benazepril Hydrochloridetablet, coated10 mg/1oralProficient Rx LP2014-01-01Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-02Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc2012-01-12Not applicableUs
Benazepril Hydrochloridetablet, coated5 mg/1oralTeva Pharmaceuticals USA Inc2004-02-11Not applicableUs
Benazepril Hydrochloridetablet20 mg/1oralBlenheim Pharmacal, Inc.2013-11-08Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-09-06Not applicableUs
Benazepril Hydrochloridetablet20 mg/1oralAv Pak2014-04-15Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralMedsource Pharmaceuticals2014-01-01Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralPhysicians Total Care, Inc.2004-08-25Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralSt Marys Medical Park Pharmacy2014-01-15Not applicableUs
Benazepril Hydrochloridetablet, coated10 mg/1oralbryant ranch prepack2009-06-29Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-14Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralRebel Distributors Corp.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet5 mg/1oralMajor Pharmaceuticals2010-02-02Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralRebel Distributors Corp.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralAv Kare, Inc.2010-07-29Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralUnit Dose Services2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralGolden State Medical Supply, Inc.2015-07-15Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralRanbaxy Pharmaceuticals Inc.2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralAurobindo Pharma Limited2008-05-22Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralInternational Laboratories, Inc.2014-02-01Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralEon Labs, Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralTrigen Laboratories, Inc.2012-11-15Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralApotex Corp2006-04-21Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralRanbaxy Pharmaceuticals Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralPreferred Pharmaceuticals, Inc2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, coated10 mg/1oralSolco healthcare U.S., LLC2014-01-01Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralMylan Pharmaceuticals Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralStat Rx USA2009-10-27Not applicableUs
Benazepril Hydrochloridetablet, coated40 mg/1oralPd Rx Pharmaceuticals, Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-09-06Not applicableUs
Benazepril Hydrochloridetablet40 mg/1oralAv Pak2014-04-15Not applicableUs
Benazepril Hydrochloridetablet, coated5 mg/1oralPd Rx Pharmaceuticals, Inc.2011-06-24Not applicableUs
Benazepril Hydrochloridetablet, coated5 mg/1oralProficient Rx LP2014-01-01Not applicableUs
Benazepril Hydrochloridetablet20 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-02Not applicableUs
Benazepril Hydrochloridetablet40 mg/1oralPreferred Pharmaceuticals Inc.2016-01-11Not applicableUs
Benazepril Hydrochloridetablet, coated10 mg/1oralTeva Pharmaceuticals USA Inc2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralBlenheim Pharmacal, Inc.2013-11-13Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralAidarex Pharmaceuticals LLC2010-02-02Not applicableUs
Benazepril Hydrochloridetablet20 mg/1oralREMEDYREPACK INC.2011-06-16Not applicableUs
Benazepril Hydrochloridetablet, coated40 mg/1oralPhysicians Total Care, Inc.2005-01-05Not applicableUs
Benazepril Hydrochloridetablet, coated10 mg/1oralREMEDYREPACK INC.2015-06-15Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralbryant ranch prepack2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, coated10 mg/1oralPreferred Pharmaceuticals, Inc.2015-03-25Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralMajor Pharmaceuticals2010-02-02Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralEon Labs, Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralTrigen Laboratories, Inc.2012-11-15Not applicableUs
Benazepril Hydrochloridetablet20 mg/1oralAv Kare, Inc.2009-07-29Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralMylan Institutional Inc.2004-05-21Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralApotex Corp2006-04-16Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralRanbaxy Pharmaceuticals Inc.2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralAurobindo Pharma Limited2008-05-22Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralNorthwind Pharmaceuticals, LLC2016-03-04Not applicableUs
Benazepril Hydrochloridetablet, coated10 mg/1oralPd Rx Pharmaceuticals, Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralInternational Laboratories, Inc.2009-03-01Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralSt. Mary's Medical Park Pharmacy2015-06-16Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralRanbaxy Pharmaceuticals Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralSolco healthcare U.S., LLC2014-01-01Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralMylan Pharmaceuticals Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralRebel Distributors Corp.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralUnit Dose Services2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralGolden State Medical Supply, Inc.2015-07-15Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralRanbaxy Pharmaceuticals Inc.2010-09-06Not applicableUs
Benazepril Hydrochloridetablet40 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-02Not applicableUs
Benazepril Hydrochloridetablet, coated40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2014-01-01Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralTeva Pharmaceuticals USA Inc2004-02-11Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralBlenheim Pharmacal, Inc.2013-11-14Not applicableUs
Benazepril Hydrochloridetablet20 mg/1oralMajor Pharmaceuticals2010-02-02Not applicableUs
Benazepril Hydrochloridetablet20 mg/1oralAidarex Pharmaceuticals LLC2010-02-02Not applicableUs
Benazepril Hydrochloridetablet5 mg/1oralAv Pak2014-04-14Not applicableUs
Benazepril Hydrochloridetablet, coated5 mg/1oralPhysicians Total Care, Inc.2005-08-19Not applicableUs
Benazepril Hydrochloridetablet, coated20 mg/1oralREMEDYREPACK INC.2015-06-15Not applicableUs
Benazepril Hydrochloridetablet, coated40 mg/1oralbryant ranch prepack2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc2012-01-12Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralEon Labs, Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralTrigen Laboratories, Inc.2012-11-15Not applicableUs
Benazepril Hydrochloridetablet40 mg/1oralAv Kare, Inc.2009-07-29Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralMylan Institutional Inc.2004-05-21Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralApotex Corp2006-04-16Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralRanbaxy Pharmaceuticals Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet40 mg/1oralAmerican Health Packaging2014-05-27Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralPreferred Pharmaceuticals Inc.2016-03-15Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralPd Rx Pharmaceuticals, Inc.2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, coated10 mg/1oralPhysicians Total Care, Inc.2004-05-17Not applicableUs
Benazepril Hydrochloridetablet20 mg/1oralSt Marys Medical Park Pharmacy2014-01-15Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralbryant ranch prepack2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralPreferred Pharmaceuticals, Inc2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, coated40 mg/1oralSolco healthcare U.S., LLC2014-01-01Not applicableUs
Benazepril Hydrochloridetablet, film coated40 mg/1oralMylan Pharmaceuticals Inc.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralRebel Distributors Corp.2004-02-11Not applicableUs
Benazepril Hydrochloridetablet5 mg/1oralAv Kare, Inc.2009-07-29Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralUnit Dose Services2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralGolden State Medical Supply, Inc.2015-07-15Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralRanbaxy Pharmaceuticals Inc.2010-09-06Not applicableUs
Benazepril Hydrochloridetablet, film coated10 mg/1oralAurobindo Pharma Limited2008-05-22Not applicableUs
Benazepril Hydrochloridetablet, coated40 mg/1oralInternational Laboratories, Inc.2014-02-01Not applicableUs
Benazepril Hydrochloridetablet, coated40 mg/1oralTeva Pharmaceuticals USA Inc2004-02-11Not applicableUs
Benazepril Hydrochloridetablet, film coated5 mg/1oralTrigen Laboratories, Inc.2012-11-15Not applicableUs
Benazepril Hydrochloridetablet40 mg/1oralMajor Pharmaceuticals2010-02-02Not applicableUs
Benazepril Hydrochloridetablet40 mg/1oralAidarex Pharmaceuticals LLC2010-02-02Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralAv Pak2014-04-15Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralCardinal Health2011-08-16Not applicableUs
Benazepril Hydrochloridetablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Benazepril Hydrochloridetablet5 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-02-02Not applicableUs
Benazepril Hydrochloridetablet, film coated20 mg/1oralPreferred Pharmaceuticals, Inc2012-01-12Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
BriemPierre Fabre (France)
CibacenNovartis (Belgium, Philippines, Switzerland, Turkey), Meda (Denmark, Germany, Greece, Ireland, Italy, Netherlands, Spain)
CibaceneMeda (France)
Brand mixtures
NameLabellerIngredients
AmlobenzRebel Distributors Corp
Amlodipine and Benazepril HydrochlorideTeva Pharmaceuticals USA Inc
Amlodipine Besylate and Benazepril HClAmerican Health Packaging
Amlodipine Besylate and Benazepril HydrochlorideActavis Pharma, Inc.
Benazepril Hydrochloride and HydrochlorothiazideEon Labs, Inc.
Lotensin HctValidus Pharmaceuticals LLC
LotrelNovartis Pharmaceuticals Corporation
Salts
Name/CASStructureProperties
Benazepril Hydrochloride
Thumb
  • InChI Key: VPSRQEHTHIMDQM-FKLPMGAJSA-N
  • Monoisotopic Mass: 460.176499755
  • Average Mass: 460.95
DBSALT000554
Categories
UNIIUDM7Q7QWP8
CAS number86541-75-5
WeightAverage: 424.4895
Monoisotopic: 424.199822016
Chemical FormulaC24H28N2O5
InChI KeyInChIKey=XPCFTKFZXHTYIP-PMACEKPBSA-N
InChI
InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
IUPAC Name
2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
SMILES
CCOC(=O)[[email protected]](CCC1=CC=CC=C1)N[[email protected]]1CCC2=CC=CC=C2N(CC(O)=O)C1=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid esters. These are ester derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid esters
Alternative Parents
Substituents
  • Alpha-amino acid ester
  • Benzazepine
  • Phenylpropylamine
  • Aralkylamine
  • Fatty acid ester
  • Azepine
  • Fatty acyl
  • Benzenoid
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Tertiary carboxylic acid amide
  • Tertiary amine
  • Lactam
  • Carboxylic acid ester
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Secondary aliphatic amine
  • Carboxylic acid
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.
PharmacodynamicsBenazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by estarases to its active Benazeprilat, is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex.
Mechanism of actionBenazeprilat, the active metabolite of Benazepril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Benazeprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.
Related Articles
AbsorptionPeak in plasma within 0.5-1.0 hours. The extent of absorption is at least 37% as determined by urinary recovery and is not significantly influenced by the presence of food in the GI tract.
Volume of distributionNot Available
Protein bindingbenazepril, 97%; benazeprilat, 95%
Metabolism

Cleavage of the ester group (primarily in the liver) converts benazepril to its active metabolite, benazeprilat. Benazepril and benazeprilat may be conjugated to glucuronic acid prior to urinary excretion.

SubstrateEnzymesProduct
Benazepril
Not Available
benazeprilatDetails
Route of eliminationBenazepril and benazeprilat are cleared predominantly by renal excretion in healthy subjects with normal renal function. Nonrenal (i.e., biliary) excretion accounts for approximately 11%-12% of benazeprilat excretion in healthy subjects.
Half life10-11 hours
Clearance
  • 0.35 L/hr/kg [pediatric hypertensive patients receiving multiple daily doses of Benazepril hydrochloride 0.1 – 0.5 mg/kg]
  • 0.13 L/hr/kg [healthy adults receiving a single dose of 10 mg]
ToxicityMost likely symptom of overdosage is severe hypotension. Most common adverse effects include headache, dizziness, fatigue, somnolence, postural dizziness, nausea, and cough.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Benazepril Metabolism PathwayDrug metabolismSMP00591
Benazepril Action PathwayDrug actionSMP00145
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.5732
Blood Brain Barrier-0.7082
Caco-2 permeable-0.7279
P-glycoprotein substrateSubstrate0.8466
P-glycoprotein inhibitor IInhibitor0.7426
P-glycoprotein inhibitor IINon-inhibitor0.7565
Renal organic cation transporterNon-inhibitor0.8239
CYP450 2C9 substrateNon-substrate0.7518
CYP450 2D6 substrateNon-substrate0.8563
CYP450 3A4 substrateSubstrate0.5632
CYP450 1A2 substrateNon-inhibitor0.8232
CYP450 2C9 inhibitorNon-inhibitor0.6875
CYP450 2D6 inhibitorNon-inhibitor0.8266
CYP450 2C19 inhibitorInhibitor0.5461
CYP450 3A4 inhibitorInhibitor0.5425
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6038
Ames testNon AMES toxic0.8377
CarcinogenicityNon-carcinogens0.9435
BiodegradationNot ready biodegradable0.9713
Rat acute toxicity2.2082 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9787
hERG inhibition (predictor II)Inhibitor0.6696
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Apotex inc etobicoke site
  • Aurobindo pharma ltd
  • Biokey inc
  • Genpharm inc
  • Huahai us inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Ranbaxy laboratories ltd
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Watson laboratories inc florida
  • Zydus pharmaceuticals usa inc
  • Novartis pharmaceuticals corp
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 mg
Tabletoral10 mg/1
Tabletoral40 mg/1
Tabletoral5 mg/1
Tablet, coatedoral10 mg/1
Tablet, coatedoral20 mg/1
Tablet, coatedoral40 mg/1
Tablet, coatedoral5 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral20 mg/1
Tablet, film coatedoral40 mg/1
Tablet, film coatedoral5 mg/1
Tablet, coatedoral
Tablet, film coatedoral
Tabletoral20 mg/1
Tabletoral20 mg
Tabletoral5 mg
Tabletoral
Capsuleoral
Prices
Unit descriptionCostUnit
Lotensin 20 mg tablet2.08USD tablet
Lotensin 10 mg tablet2.0USD tablet
Lotensin 40 mg tablet2.0USD tablet
Lotensin 5 mg tablet2.0USD tablet
Lotensin HCT 20-12.5 mg tablet1.97USD tablet
Lotensin HCT 10-12.5 mg tablet1.95USD tablet
Lotensin HCT 20-25 mg tablet1.94USD tablet
Lotensin hct 10-12.5 tablet1.9USD tablet
Lotensin hct 20-12.5 tablet1.9USD tablet
Lotensin hct 20-25 tablet1.9USD tablet
Lotensin hct 5-6.25 tablet1.9USD tablet
Lotensin HCT 5-6.25 mg tablet1.31USD tablet
Lotensin 20 mg Tablet1.14USD tablet
Benazepril hcl 10 mg tablet1.07USD tablet
Benazepril hcl 20 mg tablet1.07USD tablet
Benazepril hcl 40 mg tablet1.07USD tablet
Benazepril hcl 5 mg tablet1.07USD tablet
Lotensin 10 mg Tablet0.99USD tablet
Lotensin 5 mg Tablet0.84USD tablet
Apo-Benazepril 20 mg Tablet0.79USD tablet
Apo-Benazepril 10 mg Tablet0.69USD tablet
Apo-Benazepril 5 mg Tablet0.58USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6162802 No1997-12-192017-12-19Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point148.5 °CPhysProp
water solubility2.229 mg/LNot Available
logP3.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0105 mg/mLALOGPS
logP1.14ALOGPS
logP1.54ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)3.53ChemAxon
pKa (Strongest Basic)5.36ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area95.94 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity115.23 m3·mol-1ChemAxon
Polarizability44.98 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Wei-Hong Tseng, “ASYMMETRIC SYNTHESIS OF A KEY INTERMEDIATE FOR MAKING BENAZEPRIL AND ANALOGUES THEREOF.” U.S. Patent US20020183515, issued December 05, 2002.

US20020183515
General References
  1. Chan KK, Buch A, Glazer RD, John VA, Barr WH: Site-differential gastrointestinal absorption of benazepril hydrochloride in healthy volunteers. Pharm Res. 1994 Mar;11(3):432-7. [PubMed:8008712 ]
  2. De Feo P, Torlone E, Perriello G, Fanelli C, Epifano L, Di Vincenzo A, Modarelli F, Motolese M, Brunetti P, Bolli GB: Short-term metabolic effects of the ACE-inhibitor benazepril in type 2 diabetes mellitus associated with arterial hypertension. Diabete Metab. 1992 Jul-Aug;18(4):283-8. [PubMed:1459316 ]
  3. Gengo FM, Brady E: The pharmacokinetics of benazepril relative to other ACE inhibitors. Clin Cardiol. 1991 Aug;14(8 Suppl 4):IV44-50; discussion IV51-5. [PubMed:1893642 ]
  4. Hou FF, Zhang X, Zhang GH, Xie D, Chen PY, Zhang WR, Jiang JP, Liang M, Wang GB, Liu ZR, Geng RW: Efficacy and safety of benazepril for advanced chronic renal insufficiency. N Engl J Med. 2006 Jan 12;354(2):131-40. [PubMed:16407508 ]
  5. Ishimitsu T, Akashiba A, Kameda T, Takahashi T, Ohta S, Yoshii M, Minami J, Ono H, Numabe A, Matsuoka H: Benazepril slows progression of renal dysfunction in patients with non-diabetic renal disease. Nephrology (Carlton). 2007 Jun;12(3):294-8. [PubMed:17498126 ]
  6. MacNab M, Mallows S: Safety profile of benazepril in essential hypertension. Clin Cardiol. 1991 Aug;14(8 Suppl 4):IV33-7; discussion IV51-5. [PubMed:1893640 ]
  7. Szekacs B, Vajo Z, Dachman W: Effect of ACE inhibition by benazepril, enalapril and captopril on chronic and post exercise proteinuria. Acta Physiol Hung. 1996;84(4):361-7. [PubMed:9328608 ]
External Links
ATC CodesC09AA07C09BA07
AHFS Codes
  • 24:32.04
PDB Entries
FDA labelDownload (237 KB)
MSDSDownload (57.5 KB)
Interactions
Drug Interactions
Drug
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Benazepril.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Benazepril.
AcebutololBenazepril may increase the hypotensive activities of Acebutolol.
AceclofenacThe risk or severity of adverse effects can be increased when Benazepril is combined with Aceclofenac.
AcetazolamideThe risk or severity of adverse effects can be increased when Benazepril is combined with Acetazolamide.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Benazepril is combined with Acetylsalicylic acid.
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Benazepril.
AdapaleneThe risk or severity of adverse effects can be increased when Benazepril is combined with Adapalene.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Benazepril.
AlfuzosinAlfuzosin may increase the hypotensive activities of Benazepril.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Benazepril.
AliskirenBenazepril may increase the hypotensive activities of Aliskiren.
AllopurinolThe risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Benazepril.
AlogliptinThe risk or severity of adverse effects can be increased when Alogliptin is combined with Benazepril.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Benazepril.
AlprenololBenazepril may increase the hypotensive activities of Alprenolol.
AmbrisentanBenazepril may increase the hypotensive activities of Ambrisentan.
AmifostineBenazepril may increase the hypotensive activities of Amifostine.
AmilorideThe risk or severity of adverse effects can be increased when Benazepril is combined with Amiloride.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Benazepril.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Benazepril.
Aminosalicylic AcidAminosalicylic Acid may decrease the antihypertensive activities of Benazepril.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Benazepril.
AmlodipineAmlodipine may increase the hypotensive activities of Benazepril.
AmobarbitalAmobarbital may increase the hypotensive activities of Benazepril.
Amyl NitriteThe risk or severity of adverse effects can be increased when Benazepril is combined with Amyl Nitrite.
AntipyrineThe risk or severity of adverse effects can be increased when Benazepril is combined with Antipyrine.
ApraclonidineThe risk or severity of adverse effects can be increased when Benazepril is combined with Apraclonidine.
ApremilastThe risk or severity of adverse effects can be increased when Benazepril is combined with Apremilast.
AprotininAprotinin may decrease the antihypertensive activities of Benazepril.
ArdeparinArdeparin may increase the hyperkalemic activities of Benazepril.
AripiprazoleAripiprazole may increase the hypotensive activities of Benazepril.
AtenololAtenolol may increase the hypotensive activities of Benazepril.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Benazepril.
AtorvastatinThe risk or severity of adverse effects can be increased when Atorvastatin is combined with Benazepril.
AzapropazoneThe risk or severity of adverse effects can be increased when Benazepril is combined with Azapropazone.
AzathioprineBenazepril may increase the myelosuppressive activities of Azathioprine.
AzelastineThe risk or severity of adverse effects can be increased when Benazepril is combined with Azelastine.
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Benazepril is combined with Azilsartan medoxomil.
BalsalazideThe risk or severity of adverse effects can be increased when Benazepril is combined with Balsalazide.
BarbitalBarbital may increase the hypotensive activities of Benazepril.
BemiparinBemiparin may increase the hyperkalemic activities of Benazepril.
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Benazepril.
BenmoxinBenmoxin may increase the hypotensive activities of Benazepril.
BenoxaprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Benoxaprofen.
BepridilBenazepril may increase the hypotensive activities of Bepridil.
BetaxololBetaxolol may increase the hypotensive activities of Benazepril.
BethanidineBethanidine may increase the hypotensive activities of Benazepril.
BimatoprostBenazepril may increase the hypotensive activities of Bimatoprost.
BisoprololBenazepril may increase the hypotensive activities of Bisoprolol.
BoceprevirThe serum concentration of Benazepril can be decreased when it is combined with Boceprevir.
BosentanBenazepril may increase the hypotensive activities of Bosentan.
BretyliumBenazepril may increase the hypotensive activities of Bretylium.
BrimonidineBenazepril may increase the hypotensive activities of Brimonidine.
BrimonidineBrimonidine may increase the antihypertensive activities of Benazepril.
BromfenacThe risk or severity of adverse effects can be increased when Benazepril is combined with Bromfenac.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Benazepril.
BumetanideThe risk or severity of adverse effects can be increased when Benazepril is combined with Bumetanide.
BupranololBenazepril may increase the hypotensive activities of Bupranolol.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Benazepril.
CanagliflozinCanagliflozin may increase the hyperkalemic activities of Benazepril.
CanagliflozinThe risk or severity of adverse effects can be increased when Benazepril is combined with Canagliflozin.
CandesartanBenazepril may increase the hypotensive activities of Candesartan.
CandoxatrilBenazepril may increase the hypotensive activities of Candoxatril.
CaptoprilBenazepril may increase the hypotensive activities of Captopril.
CarbamazepineThe metabolism of Benazepril can be increased when combined with Carbamazepine.
CaroxazoneCaroxazone may increase the hypotensive activities of Benazepril.
CarprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Carprofen.
CarteololCarteolol may increase the hypotensive activities of Benazepril.
CarvedilolBenazepril may increase the hypotensive activities of Carvedilol.
CastanospermineThe risk or severity of adverse effects can be increased when Benazepril is combined with Castanospermine.
CelecoxibThe risk or severity of adverse effects can be increased when Benazepril is combined with Celecoxib.
CeliprololBenazepril may increase the hypotensive activities of Celiprolol.
CertoparinCertoparin may increase the hyperkalemic activities of Benazepril.
ChloroquineThe risk or severity of adverse effects can be increased when Benazepril is combined with Chloroquine.
ChlorothiazideBenazepril may increase the hypotensive activities of Chlorothiazide.
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Benazepril.
CilazaprilBenazepril may increase the hypotensive activities of Cilazapril.
CiprofloxacinBenazepril may increase the arrhythmogenic activities of Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Benazepril.
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Benazepril.
ClevidipineThe risk or severity of adverse effects can be increased when Benazepril is combined with Clevidipine.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Benazepril.
ClonidineBenazepril may increase the hypotensive activities of Clonidine.
ClonixinThe risk or severity of adverse effects can be increased when Benazepril is combined with Clonixin.
CryptenamineBenazepril may increase the hypotensive activities of Cryptenamine.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Benazepril.
CyclophosphamideThe risk or severity of adverse effects can be increased when Benazepril is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Benazepril.
CyclothiazideBenazepril may increase the hypotensive activities of Cyclothiazide.
D-LimoneneThe risk or severity of adverse effects can be increased when Benazepril is combined with D-Limonene.
DalteparinDalteparin may increase the hyperkalemic activities of Benazepril.
DapagliflozinThe risk or severity of adverse effects can be increased when Benazepril is combined with Dapagliflozin.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Benazepril.
DebrisoquinBenazepril may increase the hypotensive activities of Debrisoquin.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Benazepril.
DeserpidineBenazepril may increase the hypotensive activities of Deserpidine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Benazepril.
DexmedetomidineThe risk or severity of adverse effects can be increased when Benazepril is combined with Dexmedetomidine.
DiazoxideDiazoxide may increase the hypotensive activities of Benazepril.
DiclofenacThe risk or severity of adverse effects can be increased when Benazepril is combined with Diclofenac.
DiclofenamideThe risk or severity of adverse effects can be increased when Benazepril is combined with Diclofenamide.
DiflunisalThe risk or severity of adverse effects can be increased when Benazepril is combined with Diflunisal.
DiflunisalDiflunisal may decrease the antihypertensive activities of Benazepril.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Benazepril.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Benazepril.
DiltiazemDiltiazem may increase the hypotensive activities of Benazepril.
DinutuximabThe risk or severity of adverse effects can be increased when Benazepril is combined with Dinutuximab.
DipyridamoleThe risk or severity of adverse effects can be increased when Benazepril is combined with Dipyridamole.
DorzolamideBenazepril may increase the hypotensive activities of Dorzolamide.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Benazepril.
DoxazosinBenazepril may increase the hypotensive activities of Doxazosin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Benazepril.
DrospirenoneBenazepril may increase the hyperkalemic activities of Drospirenone.
DroxicamThe risk or severity of adverse effects can be increased when Benazepril is combined with Droxicam.
DuloxetineBenazepril may increase the orthostatic hypotensive activities of Duloxetine.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Benazepril.
EfonidipineBenazepril may increase the hypotensive activities of Efonidipine.
EmpagliflozinThe risk or severity of adverse effects can be increased when Benazepril is combined with Empagliflozin.
EnalaprilBenazepril may increase the hypotensive activities of Enalapril.
EnalaprilatBenazepril may increase the hypotensive activities of Enalaprilat.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Benazepril.
EnoxaparinEnoxaparin may increase the hyperkalemic activities of Benazepril.
EpirizoleThe risk or severity of adverse effects can be increased when Benazepril is combined with Epirizole.
EplerenoneEplerenone may increase the hyperkalemic activities of Benazepril.
EplerenoneThe risk or severity of adverse effects can be increased when Benazepril is combined with Eplerenone.
EpoprostenolBenazepril may increase the hypotensive activities of Epoprostenol.
EprosartanBenazepril may increase the hypotensive activities of Eprosartan.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Benazepril.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Benazepril.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Benazepril.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Benazepril.
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Benazepril.
Etacrynic acidThe risk or severity of adverse effects can be increased when Benazepril is combined with Etacrynic acid.
EtanerceptThe risk or severity of adverse effects can be increased when Benazepril is combined with Etanercept.
EtodolacThe risk or severity of adverse effects can be increased when Benazepril is combined with Etodolac.
EtofenamateThe risk or severity of adverse effects can be increased when Benazepril is combined with Etofenamate.
EtoricoxibThe risk or severity of adverse effects can be increased when Benazepril is combined with Etoricoxib.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Benazepril.
Evening primrose oilThe risk or severity of adverse effects can be increased when Benazepril is combined with Evening primrose oil.
EverolimusThe risk or severity of adverse effects can be increased when Everolimus is combined with Benazepril.
exisulindThe risk or severity of adverse effects can be increased when Benazepril is combined with exisulind.
FelodipineBenazepril may increase the hypotensive activities of Felodipine.
FenbufenThe risk or severity of adverse effects can be increased when Benazepril is combined with Fenbufen.
FenoldopamBenazepril may increase the hypotensive activities of Fenoldopam.
FenoprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Fenoprofen.
FloctafenineThe risk or severity of adverse effects can be increased when Benazepril is combined with Floctafenine.
FlunixinThe risk or severity of adverse effects can be increased when Benazepril is combined with Flunixin.
FlurbiprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Flurbiprofen.
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Benazepril.
FosinoprilFosinopril may increase the hypotensive activities of Benazepril.
FurazolidoneFurazolidone may increase the hypotensive activities of Benazepril.
FurosemideThe risk or severity of adverse effects can be increased when Benazepril is combined with Furosemide.
GarlicThe serum concentration of Benazepril can be decreased when it is combined with Garlic.
GuanabenzBenazepril may increase the hypotensive activities of Guanabenz.
GuanadrelGuanadrel may increase the hypotensive activities of Benazepril.
GuanethidineBenazepril may increase the hypotensive activities of Guanethidine.
GuanfacineBenazepril may increase the hypotensive activities of Guanfacine.
HeparinHeparin may increase the hyperkalemic activities of Benazepril.
HexamethoniumBenazepril may increase the hypotensive activities of Hexamethonium.
HexobarbitalHexobarbital may increase the hypotensive activities of Benazepril.
HMPL-004The risk or severity of adverse effects can be increased when Benazepril is combined with HMPL-004.
HydracarbazineHydracarbazine may increase the hypotensive activities of Benazepril.
HydralazineBenazepril may increase the hypotensive activities of Hydralazine.
HydrochlorothiazideHydrochlorothiazide may increase the hypotensive activities of Benazepril.
HydroflumethiazideBenazepril may increase the hypotensive activities of Hydroflumethiazide.
IbuprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Ibuprofen.
IbuproxamThe risk or severity of adverse effects can be increased when Benazepril is combined with Ibuproxam.
IcatibantIcatibant may decrease the antihypertensive activities of Benazepril.
IcatibantThe risk or severity of adverse effects can be increased when Benazepril is combined with Icatibant.
IloprostIloprost may increase the hypotensive activities of Benazepril.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Benazepril.
IndapamideBenazepril may increase the hypotensive activities of Indapamide.
IndenololBenazepril may increase the hypotensive activities of Indenolol.
IndomethacinThe risk or severity of adverse effects can be increased when Benazepril is combined with Indomethacin.
IndoprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Indoprofen.
IndoraminBenazepril may increase the hypotensive activities of Indoramin.
IproclozideIproclozide may increase the hypotensive activities of Benazepril.
IproniazidIproniazid may increase the hypotensive activities of Benazepril.
IrbesartanBenazepril may increase the hypotensive activities of Irbesartan.
IronThe risk or severity of adverse effects can be increased when Benazepril is combined with Iron.
Iron DextranThe risk or severity of adverse effects can be increased when Benazepril is combined with Iron Dextran.
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Benazepril.
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Benazepril is combined with Isosorbide Dinitrate.
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Benazepril is combined with Isosorbide Mononitrate.
IsoxicamThe risk or severity of adverse effects can be increased when Benazepril is combined with Isoxicam.
IsoxsuprineThe risk or severity of adverse effects can be increased when Benazepril is combined with Isoxsuprine.
IsradipineIsradipine may increase the hypotensive activities of Benazepril.
KebuzoneThe risk or severity of adverse effects can be increased when Benazepril is combined with Kebuzone.
KetoprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Ketoprofen.
KetorolacThe risk or severity of adverse effects can be increased when Benazepril is combined with Ketorolac.
LabetalolBenazepril may increase the hypotensive activities of Labetalol.
LacidipineBenazepril may increase the hypotensive activities of Lacidipine.
Lanthanum carbonateThe serum concentration of Benazepril can be decreased when it is combined with Lanthanum carbonate.
LatanoprostBenazepril may increase the hypotensive activities of Latanoprost.
LeflunomideThe risk or severity of adverse effects can be increased when Benazepril is combined with Leflunomide.
LercanidipineLercanidipine may increase the hypotensive activities of Benazepril.
LevobunololThe risk or severity of adverse effects can be increased when Benazepril is combined with Levobunolol.
LevodopaBenazepril may increase the orthostatic hypotensive activities of Levodopa.
LinagliptinThe risk or severity of adverse effects can be increased when Linagliptin is combined with Benazepril.
LisinoprilBenazepril may increase the hypotensive activities of Lisinopril.
LithiumThe serum concentration of Lithium can be increased when it is combined with Benazepril.
LofexidineBenazepril may increase the hypotensive activities of Lofexidine.
LornoxicamThe risk or severity of adverse effects can be increased when Benazepril is combined with Lornoxicam.
LosartanBenazepril may increase the hypotensive activities of Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Benazepril.
LoxoprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Loxoprofen.
LumiracoxibThe risk or severity of adverse effects can be increased when Benazepril is combined with Lumiracoxib.
MacitentanBenazepril may increase the hypotensive activities of Macitentan.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Benazepril is combined with Magnesium salicylate.
ManidipineBenazepril may increase the hypotensive activities of Manidipine.
MannitolThe risk or severity of adverse effects can be increased when Benazepril is combined with Mannitol.
MasoprocolThe risk or severity of adverse effects can be increased when Benazepril is combined with Masoprocol.
MebanazineMebanazine may increase the hypotensive activities of Benazepril.
MecamylamineBenazepril may increase the hypotensive activities of Mecamylamine.
Meclofenamic acidThe risk or severity of adverse effects can be increased when Benazepril is combined with Meclofenamic acid.
Mefenamic acidThe risk or severity of adverse effects can be increased when Benazepril is combined with Mefenamic acid.
MeloxicamThe risk or severity of adverse effects can be increased when Benazepril is combined with Meloxicam.
MesalazineThe risk or severity of adverse effects can be increased when Benazepril is combined with Mesalazine.
MesalazineMesalazine may decrease the antihypertensive activities of Benazepril.
MetamizoleThe risk or severity of adverse effects can be increased when Benazepril is combined with Metamizole.
MethazolamideThe risk or severity of adverse effects can be increased when Benazepril is combined with Methazolamide.
MethohexitalMethohexital may increase the hypotensive activities of Benazepril.
MethyclothiazideMethyclothiazide may increase the hypotensive activities of Benazepril.
MethyclothiazideThe risk or severity of adverse effects can be increased when Benazepril is combined with Methyclothiazide.
MethyldopaBenazepril may increase the hypotensive activities of Methyldopa.
Methylene blueMethylene blue may increase the hypotensive activities of Benazepril.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Benazepril.
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Benazepril.
MetipranololBenazepril may increase the hypotensive activities of Metipranolol.
MetolazoneMetolazone may increase the hypotensive activities of Benazepril.
MetoprololMetoprolol may increase the hypotensive activities of Benazepril.
MibefradilBenazepril may increase the hypotensive activities of Mibefradil.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Benazepril.
MinaprineMinaprine may increase the hypotensive activities of Benazepril.
MinoxidilMinoxidil may increase the hypotensive activities of Benazepril.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Benazepril.
MoclobemideMoclobemide may increase the hypotensive activities of Benazepril.
MoexiprilBenazepril may increase the hypotensive activities of Moexipril.
MolsidomineMolsidomine may increase the hypotensive activities of Benazepril.
MoxonidineBenazepril may increase the hypotensive activities of Moxonidine.
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Benazepril is combined with Mycophenolate mofetil.
Mycophenolic acidThe risk or severity of adverse effects can be increased when Benazepril is combined with Mycophenolic acid.
NabumetoneThe risk or severity of adverse effects can be increased when Benazepril is combined with Nabumetone.
NadololBenazepril may increase the hypotensive activities of Nadolol.
NadroparinNadroparin may increase the hyperkalemic activities of Benazepril.
NaftifineThe risk or severity of adverse effects can be increased when Benazepril is combined with Naftifine.
NaproxenThe risk or severity of adverse effects can be increased when Benazepril is combined with Naproxen.
NCX 4016The risk or severity of adverse effects can be increased when Benazepril is combined with NCX 4016.
NebivololBenazepril may increase the hypotensive activities of Nebivolol.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Benazepril.
NepafenacThe risk or severity of adverse effects can be increased when Benazepril is combined with Nepafenac.
NesiritideThe risk or severity of adverse effects can be increased when Benazepril is combined with Nesiritide.
NialamideNialamide may increase the hypotensive activities of Benazepril.
NicardipineBenazepril may increase the hypotensive activities of Nicardipine.
NicorandilNicorandil may increase the hypotensive activities of Benazepril.
NifedipineThe risk or severity of adverse effects can be increased when Benazepril is combined with Nifedipine.
Niflumic AcidThe risk or severity of adverse effects can be increased when Benazepril is combined with Niflumic Acid.
NiguldipineBenazepril may increase the hypotensive activities of Niguldipine.
NilvadipineBenazepril may increase the hypotensive activities of Nilvadipine.
NimesulideThe risk or severity of adverse effects can be increased when Benazepril is combined with Nimesulide.
NimodipineNimodipine may increase the hypotensive activities of Benazepril.
NisoldipineNisoldipine may increase the hypotensive activities of Benazepril.
NitrendipineBenazepril may increase the hypotensive activities of Nitrendipine.
NitroglycerinThe risk or severity of adverse effects can be increased when Benazepril is combined with Nitroglycerin.
NitroprussideNitroprusside may increase the hypotensive activities of Benazepril.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Benazepril.
ObinutuzumabBenazepril may increase the hypotensive activities of Obinutuzumab.
OctamoxinOctamoxin may increase the hypotensive activities of Benazepril.
OlmesartanOlmesartan may increase the hypotensive activities of Benazepril.
OlopatadineThe risk or severity of adverse effects can be increased when Benazepril is combined with Olopatadine.
OlsalazineThe risk or severity of adverse effects can be increased when Benazepril is combined with Olsalazine.
OmapatrilatBenazepril may increase the hypotensive activities of Omapatrilat.
OrgoteinThe risk or severity of adverse effects can be increased when Benazepril is combined with Orgotein.
OxaprozinThe risk or severity of adverse effects can be increased when Benazepril is combined with Oxaprozin.
OxprenololBenazepril may increase the hypotensive activities of Oxprenolol.
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Benazepril is combined with Oxyphenbutazone.
PapaverineThe risk or severity of adverse effects can be increased when Benazepril is combined with Papaverine.
ParecoxibThe risk or severity of adverse effects can be increased when Benazepril is combined with Parecoxib.
PargylineBenazepril may increase the hypotensive activities of Pargyline.
ParnaparinParnaparin may increase the hyperkalemic activities of Benazepril.
PenbutololBenazepril may increase the hypotensive activities of Penbutolol.
PentobarbitalPentobarbital may increase the hypotensive activities of Benazepril.
PentoliniumBenazepril may increase the hypotensive activities of Pentolinium.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Benazepril.
PerindoprilBenazepril may increase the hypotensive activities of Perindopril.
PethidineThe risk or severity of adverse effects can be increased when Benazepril is combined with Pethidine.
PhenelzinePhenelzine may increase the hypotensive activities of Benazepril.
PheniprazinePheniprazine may increase the hypotensive activities of Benazepril.
PhenobarbitalPhenobarbital may increase the hypotensive activities of Benazepril.
PhenoxybenzamineBenazepril may increase the hypotensive activities of Phenoxybenzamine.
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Benazepril.
PhentolamineBenazepril may increase the hypotensive activities of Phentolamine.
PhenylbutazoneThe risk or severity of adverse effects can be increased when Benazepril is combined with Phenylbutazone.
PimecrolimusThe risk or severity of adverse effects can be increased when Benazepril is combined with Pimecrolimus.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Benazepril.
PinacidilBenazepril may increase the hypotensive activities of Pinacidil.
PindololBenazepril may increase the hypotensive activities of Pindolol.
PiretanidePiretanide may increase the hypotensive activities of Benazepril.
PirfenidoneThe risk or severity of adverse effects can be increased when Benazepril is combined with Pirfenidone.
PirlindolePirlindole may increase the hypotensive activities of Benazepril.
PiroxicamThe risk or severity of adverse effects can be increased when Benazepril is combined with Piroxicam.
PivhydrazinePivhydrazine may increase the hypotensive activities of Benazepril.
PolythiazideBenazepril may increase the hypotensive activities of Polythiazide.
PrazosinPrazosin may increase the hypotensive activities of Benazepril.
PregabalinThe risk or severity of adverse effects can be increased when Benazepril is combined with Pregabalin.
PrimidonePrimidone may increase the hypotensive activities of Benazepril.
PropacetamolThe risk or severity of adverse effects can be increased when Benazepril is combined with Propacetamol.
PropranololBenazepril may increase the hypotensive activities of Propranolol.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Benazepril.
PTC299The risk or severity of adverse effects can be increased when Benazepril is combined with PTC299.
QuetiapineThe risk or severity of adverse effects can be increased when Benazepril is combined with Quetiapine.
QuinaprilBenazepril may increase the hypotensive activities of Quinapril.
QuinethazoneQuinethazone may increase the hypotensive activities of Benazepril.
QuinineQuinine may increase the hypotensive activities of Benazepril.
RamiprilRamipril may increase the hypotensive activities of Benazepril.
RasagilineRasagiline may increase the hypotensive activities of Benazepril.
RemikirenRemikiren may increase the hypotensive activities of Benazepril.
RescinnamineBenazepril may increase the hypotensive activities of Rescinnamine.
ReserpineReserpine may increase the hypotensive activities of Benazepril.
ResveratrolThe risk or severity of adverse effects can be increased when Benazepril is combined with Resveratrol.
ReviparinReviparin may increase the hyperkalemic activities of Benazepril.
RiociguatBenazepril may increase the hypotensive activities of Riociguat.
RisperidoneBenazepril may increase the hypotensive activities of Risperidone.
RituximabBenazepril may increase the hypotensive activities of Rituximab.
RofecoxibThe risk or severity of adverse effects can be increased when Benazepril is combined with Rofecoxib.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Benazepril.
SacubitrilThe risk or severity of adverse effects can be increased when Benazepril is combined with Sacubitril.
SafrazineSafrazine may increase the hypotensive activities of Benazepril.
SalicylamideThe risk or severity of adverse effects can be increased when Benazepril is combined with Salicylamide.
Salicylic acidThe risk or severity of adverse effects can be increased when Benazepril is combined with Salicylic acid.
Salicylic acidSalicylic acid may decrease the antihypertensive activities of Benazepril.
SalsalateThe risk or severity of adverse effects can be increased when Benazepril is combined with Salsalate.
SaprisartanBenazepril may increase the hypotensive activities of Saprisartan.
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Benazepril.
SaxagliptinThe risk or severity of adverse effects can be increased when Saxagliptin is combined with Benazepril.
SecobarbitalSecobarbital may increase the hypotensive activities of Benazepril.
SelegilineSelegiline may increase the hypotensive activities of Benazepril.
SelexipagBenazepril may increase the hypotensive activities of Selexipag.
SeratrodastThe risk or severity of adverse effects can be increased when Benazepril is combined with Seratrodast.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Benazepril.
SildenafilSildenafil may increase the antihypertensive activities of Benazepril.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Benazepril.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Benazepril.
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Benazepril.
SitagliptinThe risk or severity of adverse effects can be increased when Sitagliptin is combined with Benazepril.
SitaxentanBenazepril may increase the hypotensive activities of Sitaxentan.
Sodium aurothiomalateThe risk or severity of adverse effects can be increased when Benazepril is combined with Sodium aurothiomalate.
SotalolThe risk or severity of adverse effects can be increased when Sotalol is combined with Benazepril.
SpiraprilBenazepril may increase the hypotensive activities of Spirapril.
SpironolactoneThe risk or severity of adverse effects can be increased when Spironolactone is combined with Benazepril.
SRT501The risk or severity of adverse effects can be increased when Benazepril is combined with SRT501.
St. John's WortThe metabolism of Benazepril can be increased when combined with St. John's Wort.
SulfasalazineThe risk or severity of adverse effects can be increased when Benazepril is combined with Sulfasalazine.
SulindacThe risk or severity of adverse effects can be increased when Benazepril is combined with Sulindac.
SuprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Suprofen.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Benazepril.
TadalafilTadalafil may increase the antihypertensive activities of Benazepril.
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Benazepril.
TelmisartanBenazepril may increase the hypotensive activities of Telmisartan.
TemocaprilBenazepril may increase the hypotensive activities of Temocapril.
TemsirolimusThe risk or severity of adverse effects can be increased when Temsirolimus is combined with Benazepril.
TenoxicamThe risk or severity of adverse effects can be increased when Benazepril is combined with Tenoxicam.
TepoxalinThe risk or severity of adverse effects can be increased when Benazepril is combined with Tepoxalin.
TerazosinThe risk or severity of adverse effects can be increased when Benazepril is combined with Terazosin.
TeriflunomideThe risk or severity of adverse effects can be increased when Benazepril is combined with Teriflunomide.
TerlipressinBenazepril may increase the hypotensive activities of Terlipressin.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Benazepril.
ThiamylalThiamylal may increase the hypotensive activities of Benazepril.
ThiopentalThiopental may increase the hypotensive activities of Benazepril.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Benazepril.
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Benazepril is combined with Tiaprofenic acid.
TiboloneBenazepril may increase the hypotensive activities of Tibolone.
TicrynafenBenazepril may increase the hypotensive activities of Ticrynafen.
TimololTimolol may increase the hypotensive activities of Benazepril.
TinzaparinTinzaparin may increase the hyperkalemic activities of Benazepril.
TipranavirThe serum concentration of Benazepril can be decreased when it is combined with Tipranavir.
TizanidineTizanidine may increase the hypotensive activities of Benazepril.
TizanidineThe risk or severity of adverse effects can be increased when Benazepril is combined with Tizanidine.
TolazolineBenazepril may increase the hypotensive activities of Tolazoline.
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Benazepril is combined with Tolfenamic Acid.
TolmetinThe risk or severity of adverse effects can be increased when Benazepril is combined with Tolmetin.
ToloxatoneToloxatone may increase the hypotensive activities of Benazepril.
TolvaptanTolvaptan may increase the hyperkalemic activities of Benazepril.
TorasemideTorasemide may increase the hypotensive activities of Benazepril.
TrandolaprilTrandolapril may increase the hypotensive activities of Benazepril.
TranilastThe risk or severity of adverse effects can be increased when Benazepril is combined with Tranilast.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Benazepril.
TranylcypromineTranylcypromine may increase the hypotensive activities of Benazepril.
TravoprostTravoprost may increase the hypotensive activities of Benazepril.
TreprostinilTreprostinil may increase the hypotensive activities of Benazepril.
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Benazepril.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Benazepril.
TrichlormethiazideBenazepril may increase the hypotensive activities of Trichlormethiazide.
TrimazosinBenazepril may increase the hypotensive activities of Trimazosin.
TrimethaphanBenazepril may increase the hypotensive activities of Trimethaphan.
TrimethoprimTrimethoprim may increase the hyperkalemic activities of Benazepril.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Benazepril.
Trisalicylate-cholineThe risk or severity of adverse effects can be increased when Benazepril is combined with Trisalicylate-choline.
UdenafilUdenafil may increase the antihypertensive activities of Benazepril.
UnoprostoneBenazepril may increase the hypotensive activities of Unoprostone.
ValdecoxibThe risk or severity of adverse effects can be increased when Benazepril is combined with Valdecoxib.
ValsartanValsartan may increase the hypotensive activities of Benazepril.
VardenafilVardenafil may increase the antihypertensive activities of Benazepril.
VerapamilThe risk or severity of adverse effects can be increased when Benazepril is combined with Verapamil.
VildagliptinThe risk or severity of adverse effects can be increased when Vildagliptin is combined with Benazepril.
XylometazolineBenazepril may increase the hypotensive activities of Xylometazoline.
YohimbineYohimbine may decrease the antihypertensive activities of Benazepril.
ZaltoprofenThe risk or severity of adverse effects can be increased when Benazepril is combined with Zaltoprofen.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Benazepril.
ZileutonThe risk or severity of adverse effects can be increased when Benazepril is combined with Zileuton.
ZomepiracThe risk or severity of adverse effects can be increased when Benazepril is combined with Zomepirac.
Food Interactions
  • Benazepril may decrease the excretion of potassium. Salt um may increase the risk of hyperkalemia. substitutes containing potassi
  • Food slows absorption without decreasing the quantity absorbed.
  • Herbs that may attenuate the antihypertensive effect of benazepril include: bayberry, blue cohash, cayenne, ephedra, ginger, ginseng (American), kola and licorice.
  • High salt intake may attenuate the antihypertensive effect of benazepril.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Gene Name:
ACE
Uniprot ID:
P12821
Molecular Weight:
149713.675 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Song JC, White CM: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. [PubMed:11929321 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Protein complex binding
Specific Function:
Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
Gene Name:
MTHFR
Uniprot ID:
P42898
Molecular Weight:
74595.895 Da
References
  1. Jiang S, Yu Y, Venners SA, Zhang Y, Xing H, Wang X, Xu X: Effects of MTHFR and MS gene polymorphisms on baseline blood pressure and Benazepril effectiveness in Chinese hypertensive patients. J Hum Hypertens. 2011 Mar;25(3):172-7. doi: 10.1038/jhh.2010.50. Epub 2010 May 6. [PubMed:20445573 ]
  2. Jiang S, Hsu YH, Niu T, Xu X, Xing H, Chen C, Wang X, Zhang Y, Peng S, Xu X: A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study. Clin Exp Hypertens. 2005 Aug;27(6):509-21. [PubMed:16081343 ]
  3. Jiang S, Hsu YH, Xu X, Xing H, Chen C, Niu T, Zhang Y, Peng S, Xu X: The C677T polymorphism of the methylenetetrahydrofolate reductase gene is associated with the level of decrease on diastolic blood pressure in essential hypertension patients treated by angiotensin-converting enzyme inhibitor. Thromb Res. 2004;113(6):361-9. [PubMed:15226090 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Proton-dependent oligopeptide secondary active transmembrane transporter activity
Specific Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
Gene Name:
SLC15A1
Uniprot ID:
P46059
Molecular Weight:
78805.265 Da
References
  1. Knutter I, Wollesky C, Kottra G, Hahn MG, Fischer W, Zebisch K, Neubert RH, Daniel H, Brandsch M: Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. doi: 10.1124/jpet.108.143339. Epub 2008 Aug 19. [PubMed:18713951 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Peptide:proton symporter activity
Specific Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.
Gene Name:
SLC15A2
Uniprot ID:
Q16348
Molecular Weight:
81782.77 Da
References
  1. Knutter I, Wollesky C, Kottra G, Hahn MG, Fischer W, Zebisch K, Neubert RH, Daniel H, Brandsch M: Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. doi: 10.1124/jpet.108.143339. Epub 2008 Aug 19. [PubMed:18713951 ]
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Drug created on June 13, 2005 07:24 / Updated on September 30, 2016 02:25