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Identification
NameAmlodipine
Accession NumberDB00381  (APRD00520)
TypeSmall Molecule
GroupsApproved
DescriptionAmlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina.
Structure
Thumb
Synonyms
(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
Amlodipine
Amlodipine free base
Amlodipino
Amlodipinum
External Identifiers
  • UK 48340-11
  • UK 48340-26
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Accel-amlodipinetablet5 mgoralAccel Pharma Inc2010-03-05Not applicableCanada
Accel-amlodipinetablet10 mgoralAccel Pharma Inc2010-03-05Not applicableCanada
Accel-amlodipinetablet2.5 mgoralAccel Pharma IncNot applicableNot applicableCanada
Act Amlodipinetablet2.5 mgoralActavis Pharma Company2010-03-02Not applicableCanada
Act Amlodipinetablet5 mgoralActavis Pharma Company2009-07-10Not applicableCanada
Act Amlodipinetablet10 mgoralActavis Pharma Company2009-07-10Not applicableCanada
Ag-amlodipinetablet10 mgoralAngita Pharma Inc.2014-09-25Not applicableCanada
Ag-amlodipinetablet2.5 mgoralAngita Pharma Inc.Not applicableNot applicableCanada
Ag-amlodipinetablet5 mgoralAngita Pharma Inc.2014-09-25Not applicableCanada
Amlodipinetablet5 mgoralMeliapharm Inc2011-04-082014-06-25Canada
Amlodipinetablet10 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Amlodipinetablet10 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Amlodipinetablet10 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Amlodipinetablet10 mgoralSanis Health Inc2009-10-22Not applicableCanada
Amlodipinetablet10 mgoralMeliapharm Inc2011-04-082014-06-25Canada
Amlodipinetablet5 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Amlodipinetablet5 mgoralJamp Pharma Corporation2014-09-04Not applicableCanada
Amlodipinetablet2.5 mgoralPro Doc Limitee2009-07-22Not applicableCanada
Amlodipinetablet10 mgoralJamp Pharma Corporation2014-09-04Not applicableCanada
Amlodipinetablet2.5 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Amlodipinetablet2.5 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Amlodipinetablet5.0 mgoralPro Doc Limitee2009-07-22Not applicableCanada
Amlodipinetablet2.5 mgoralMeliapharm Inc2011-04-082014-06-25Canada
Amlodipinetablet5 mgoralSivem Pharmaceuticals Ulc2012-06-12Not applicableCanada
Amlodipinetablet5 mgoralSanis Health Inc2009-10-22Not applicableCanada
Amlodipinetablet10.0 mgoralPro Doc Limitee2009-07-22Not applicableCanada
Amlodipinetablet5 mgoralActavis Pharma CompanyNot applicableNot applicableCanada
Amlodipine Besylatetablet10 mg/1oralRed Pharm Drug Inc.1992-07-31Not applicableUs
Amlodipine Besylatetablet10 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1992-07-31Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralPd Rx Pharmaceuticals, Inc.1992-07-31Not applicableUs
Amlodipine Besylatetablet10 mg/1oralKAISER FOUNDATION HOSPITALS2008-10-21Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralSt Marys Medical Park Pharmacy2014-05-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAvera Mc Kennan Hospital2015-07-21Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralGreenstone LLC2007-03-23Not applicableUs
Amlodipine Besylatetablet5 mg/1oralKAISER FOUNDATION HOSPITALS2008-10-21Not applicableUs
Amlodipine Besylatetablet10 mg/1oralContract Pharmacy Services Pa1992-07-31Not applicableUs
Amlodipine Besylatetablet5 mg/1oralGreenstone LLC2007-03-23Not applicableUs
Amlodipine Besylatetablet5 mg/1oralRed Pharm Drug Inc.1992-07-31Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCardinal Health1992-07-31Not applicableUs
Amlodipine Besylatetablet10 mg/1oralGreenstone LLC2007-03-23Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralKAISER FOUNDATION HOSPITALS2008-10-21Not applicableUs
Amlodipine Besylatetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.1992-07-31Not applicableUs
Amlodipine Besylate Tablets USPtablet10 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Amlodipine Besylate Tablets USPtablet2.5 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Amlodipine Besylate Tablets USPtablet5 mgoralAccord Healthcare IncNot applicableNot applicableCanada
Amlodipine Besylate Tablets, 10mgtablet10.0 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Amlodipine Besylate Tablets, 5mgtablet5.0 mgoralDr Reddys Laboratories IncNot applicableNot applicableCanada
Amlodipine Tabletstablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Amlodipine Tabletstablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Amlodipine-odantablet2.5 mgoralOdan Laboratories Ltd2012-03-082012-12-31Canada
Amlodipine-odantablet5.0 mgoralOdan Laboratories Ltd2012-03-082014-11-12Canada
Amlodipine-odantablet10.0 mgoralOdan Laboratories Ltd2012-03-082014-11-12Canada
Auro-amlodipinetablet5 mgoralAuro Pharma Inc2013-02-12Not applicableCanada
Auro-amlodipinetablet10 mgoralAuro Pharma Inc2013-02-12Not applicableCanada
Bio-amlodipinetablet10.00 mgoralBiomed Pharma2013-01-15Not applicableCanada
Bio-amlodipinetablet2.5 mgoralBiomed Pharma2013-01-15Not applicableCanada
Bio-amlodipinetablet5.00 mgoralBiomed Pharma2013-01-15Not applicableCanada
Dom-amlodipinetablet2.5 mgoralDominion Pharmacal2010-01-13Not applicableCanada
Dom-amlodipinetablet5.0 mgoralDominion Pharmacal2010-01-13Not applicableCanada
Dom-amlodipinetablet10.0 mgoralDominion Pharmacal2010-01-13Not applicableCanada
Gd-amlodipinetablet10 mgoralGenmed A Division Of Pfizer Canada Inc2009-07-22Not applicableCanada
Gd-amlodipinetablet2.5 mgoralGenmed A Division Of Pfizer Canada Inc2012-07-23Not applicableCanada
Gd-amlodipinetablet5 mgoralGenmed A Division Of Pfizer Canada Inc2009-07-22Not applicableCanada
Ipg-amlodipinetablet2.5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-amlodipinetablet5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Ipg-amlodipinetablet10 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Jamp-amlodipinetablet5 mgoralJamp Pharma Corporation2010-03-182014-11-07Canada
Jamp-amlodipinetablet10 mgoralJamp Pharma Corporation2011-01-27Not applicableCanada
Jamp-amlodipinetablet10 mgoralJamp Pharma Corporation2010-03-182014-11-07Canada
Jamp-amlodipinetablet2.5 mgoralJamp Pharma Corporation2011-01-27Not applicableCanada
Jamp-amlodipinetablet5 mgoralJamp Pharma Corporation2011-01-27Not applicableCanada
Manda-amlodipine Tabletstablet10 mgoralManda Pharma Inc2012-06-012013-08-22Canada
Manda-amlodipine Tabletstablet2.5 mgoralManda Pharma Inc2012-06-012013-08-22Canada
Manda-amlodipine Tabletstablet5 mgoralManda Pharma Inc2012-06-012013-08-22Canada
Mar-amlodipine Tabletstablet10 mgoralMarcan Pharmaceuticals Inc2012-10-24Not applicableCanada
Mar-amlodipine Tabletstablet2.5 mgoralMarcan Pharmaceuticals Inc2012-10-24Not applicableCanada
Mar-amlodipine Tabletstablet5 mgoralMarcan Pharmaceuticals Inc2012-10-24Not applicableCanada
Mint-amlodipinetablet5 mgoralMint Pharmaceuticals Inc2011-02-16Not applicableCanada
Mint-amlodipinetablet10 mgoralMint Pharmaceuticals Inc2011-02-16Not applicableCanada
Mylan-amlodipinetablet5.0 mgoralMylan Pharmaceuticals Ulc2009-07-09Not applicableCanada
Mylan-amlodipinetablet10.0 mgoralMylan Pharmaceuticals Ulc2009-07-09Not applicableCanada
Norvasctablet2.5 mg/1oralPfizer Laboratories Div Pfizer Inc1992-07-31Not applicableUs
Norvasctablet5 mg/1oralCardinal Health1992-07-31Not applicableUs
Norvasctablet10 mg/1oralLake Erie Medical & Surgical Supplies DBA Quality Care Products LLC2011-11-22Not applicableUs
Norvasctablet5 mg/1oralPfizer Laboratories Div Pfizer Inc1992-07-31Not applicableUs
Norvasctablet10 mg/1oralCardinal Health1992-07-31Not applicableUs
Norvasctablet10 mg/1oralREMEDYREPACK INC.2013-03-042016-04-05Us
Norvasctablet10 mg/1oralPfizer Laboratories Div Pfizer Inc1992-07-31Not applicableUs
Norvasctablet5 mg/1oralPd Rx Pharmaceuticals, Inc.1992-07-31Not applicableUs
Norvasctablet5 mg/1oralRebel Distributors Corp1992-07-31Not applicableUs
Norvasc Tab 10mgtablet10 mgoralPfizer Canada Inc1992-12-31Not applicableCanada
Norvasc Tab 2.5mgtablet2.5 mgoralPfizer Canada IncNot applicableNot applicableCanada
Norvasc Tab 5mgtablet5 mgoralPfizer Canada Inc1992-12-31Not applicableCanada
PHL-amlodipinetablet10.0 mgoralPharmel Inc2009-07-16Not applicableCanada
PHL-amlodipinetablet2.5 mgoralPharmel Inc2009-07-21Not applicableCanada
PHL-amlodipinetablet5.0 mgoralPharmel Inc2009-07-16Not applicableCanada
PMS-amlodipinetablet5.0 mgoralPharmascience Inc2009-07-09Not applicableCanada
PMS-amlodipinetablet10.0 mgoralPharmascience Inc2009-07-09Not applicableCanada
PMS-amlodipinetablet2.5 mgoralPharmascience Inc2009-07-15Not applicableCanada
Priva-amlodipinetablet2.5 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-amlodipinetablet5 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-amlodipinetablet10 mgoralPharmapar IncNot applicableNot applicableCanada
Q-amlodipinetablet5 mgoralQd Pharmaceuticals Ulc2011-10-032015-08-21Canada
Q-amlodipinetablet10 mgoralQd Pharmaceuticals Ulc2011-10-032015-08-21Canada
Q-gen Amlodipinetablet10 mgoralQ Gen Pharmaceuticals IncNot applicableNot applicableCanada
Q-gen Amlodipinetablet5 mgoralQ Gen Pharmaceuticals IncNot applicableNot applicableCanada
Ran-amlodipinetablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-09Not applicableCanada
Ran-amlodipinetablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.2009-07-09Not applicableCanada
Ran-amlodipinetablet2.5 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-06-07Not applicableCanada
Ratio-amlodipine Tablets 10mgtablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited2009-07-092014-09-19Canada
Ratio-amlodipine Tablets 5mgtablet5 mgoralRatiopharm Inc Division Of Teva Canada Limited2009-07-092014-09-19Canada
Riva-amlodipinetablet2.5 mgoralLaboratoire Riva Inc2009-10-13Not applicableCanada
Riva-amlodipinetablet5 mgoralLaboratoire Riva Inc2009-10-07Not applicableCanada
Riva-amlodipinetablet10 mgoralLaboratoire Riva Inc2009-10-06Not applicableCanada
Sandoz Amlodipinetablet5 mgoralSandoz Canada Incorporated2009-07-09Not applicableCanada
Sandoz Amlodipinetablet10 mgoralSandoz Canada Incorporated2009-07-09Not applicableCanada
Sandoz Amlodipinetablet10 mgoralSandoz Canada Incorporated2009-07-09Not applicableCanada
Sandoz Amlodipinetablet5 mgoralSandoz Canada Incorporated2009-07-09Not applicableCanada
Sandoz Amlodipinetablet2.5 mgoralSandoz Canada Incorporated2009-08-05Not applicableCanada
Septa-amlodipinetablet2.5 mgoralSepta Pharmaceuticals Inc2010-11-22Not applicableCanada
Septa-amlodipinetablet5 mgoralSepta Pharmaceuticals Inc2010-11-22Not applicableCanada
Septa-amlodipinetablet10 mgoralSepta Pharmaceuticals Inc2010-11-22Not applicableCanada
Teva-amlodipinetablet5 mgoralTeva Canada Limited2009-07-09Not applicableCanada
Teva-amlodipinetablet10 mgoralTeva Canada Limited2009-07-09Not applicableCanada
Van-amlodipinetablet5 mgoralVanc Pharmaceuticals Inc2015-06-22Not applicableCanada
Van-amlodipinetablet10 mgoralVanc Pharmaceuticals Inc2015-06-22Not applicableCanada
Zym-amlodipinetablet5.0 mgoralZymcan Pharmaceuticals Inc2010-04-292014-06-16Canada
Zym-amlodipinetablet10.0 mgoralZymcan Pharmaceuticals Inc2010-04-292014-06-16Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Amlodipinetablet10 mg/1oralREMEDYREPACK INC.2011-04-13Not applicableUs
Amlodipinetablet10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Amlodipinetablet5 mg/1oralMacleods Pharmaceuticals Limited2012-04-13Not applicableUs
Amlodipinetablet10 mg/1oralMacleods Pharmaceuticals Limited2012-04-13Not applicableUs
Amlodipine Besylatetablet10 mg/1oralMajor Pharmaceuticals2010-12-03Not applicableUs
Amlodipine Besylatetablet5 mg/1oralUnichem Pharmaceuticals (USA), Inc.2014-03-03Not applicableUs
Amlodipine Besylatetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2010-10-20Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAv Pak2014-01-10Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCardinal Health2014-01-10Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralClinical Solutions Wholesale2010-04-07Not applicableUs
Amlodipine Besylatetablet5 mg/1oralWest Ward Pharmaceuticals Corp2011-04-12Not applicableUs
Amlodipine Besylatetablet5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralWockhardt USA LLC.2007-09-06Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAscend Laboratories, LLC2010-10-20Not applicableUs
Amlodipine Besylatetablet10 mg/1oralCipla USA Inc.2007-09-26Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAidarex Pharmaceuticals LLC2011-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-03-11Not applicableUs
Amlodipine Besylatetablet10 mg/1oralBlenheim Pharmacal, Inc.2011-04-25Not applicableUs
Amlodipine Besylatetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-04-07Not applicableUs
Amlodipine Besylatetablet5 mg/1oralREMEDYREPACK INC.2013-05-132016-04-05Us
Amlodipine Besylatetablet2.5 mg/1oralDr Reddy's Laboratories2007-07-23Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralWockhardt Limited2007-09-06Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralRoxane Laboratories, Inc2007-07-09Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralApotex Corp.2007-05-24Not applicableUs
Amlodipine Besylatetablet5 mg/1oralRanbaxy Pharmaceuticals Inc2007-07-09Not applicableUs
Amlodipine Besylatetablet10 mg/1oralCadila Healthcare Limited2007-09-21Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2007-09-21Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralMajor Pharmaceuticals2009-06-102015-12-31Us
Amlodipine Besylatetablet10 mg/1oralProficient Rx LP2014-03-03Not applicableUs
Amlodipine Besylatetablet10 mg/1oralMylan Pharmaceuticals Inc.2007-03-23Not applicableUs
Amlodipine Besylatetablet5 mg/1oralProficient Rx LP2011-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-06-21Not applicableUs
Amlodipine Besylatetablet10 mg/1oralCarilion Materials Management2011-01-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralMc Kesson Contract Packaging2011-09-14Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralBiomes Pharmaceuticals LLC2011-04-15Not applicableUs
Amlodipine Besylatetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralMajor Pharmaceuticals2013-01-20Not applicableUs
Amlodipine Besylatetablet10 mg/1oralCamber Pharmaceuticals, Inc.2011-01-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralSecan Pharmaceuticals Inc.2011-04-15Not applicableUs
Amlodipine Besylatetablet5 mg/1oralMylan Institutional Inc.2007-04-02Not applicableUs
Amlodipine Besylatetablet5 mg/1oralInternational Labs, Inc.2012-02-20Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCardinal Health2010-01-14Not applicableUs
Amlodipine Besylatetablet10 mg/1oralHikma Pharmaceutical2011-04-12Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2012-10-19Not applicableUs
Amlodipine Besylatetablet5 mg/1oralTeva Pharmaceuticals USA Inc2007-07-10Not applicableUs
Amlodipine Besylatetablet10 mg/1oralREMEDYREPACK INC.2015-02-26Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralbryant ranch prepack2007-05-24Not applicableUs
Amlodipine Besylatetablet5 mg/1oralMed Vantx, Inc.2010-03-23Not applicableUs
Amlodipine Besylatetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2014-11-24Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAmerican Health Packaging2013-07-232015-12-29Us
Amlodipine Besylatetablet10 mg/1oralSt Marys Medical Park Pharmacy2011-09-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralUpsher Smith Laboratories, Inc.2007-07-09Not applicableUs
Amlodipine Besylatetablet5 mg/1oralSTAT Rx USA LLC2007-09-06Not applicableUs
Amlodipine Besylatetablet10 mg/1oralEpic Pharma, LLC2011-04-25Not applicableUs
Amlodipine Besylatetablet5 mg/1oralREMEDYREPACK INC.2011-09-14Not applicableUs
Amlodipine Besylatetablet10 mg/1oralREMEDYREPACK INC.2014-04-04Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCardinal Health2011-06-01Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralMajor Pharmaceuticals2010-12-03Not applicableUs
Amlodipine Besylatetablet10 mg/1oralUnichem Pharmaceuticals (USA), Inc.2014-03-03Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-04-07Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAv Pak2014-01-10Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCardinal Health2014-02-03Not applicableUs
Amlodipine Besylatetablet10 mg/1oralNew Horizon Rx Group, LLC2013-08-25Not applicableUs
Amlodipine Besylatetablet10 mg/1oralWest Ward Pharmaceuticals Corp2011-04-12Not applicableUs
Amlodipine Besylatetablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralWockhardt USA LLC.2007-09-06Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAvera Mc Kennan Hospital2015-03-05Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAidarex Pharmaceuticals LLC2011-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralClinical Solutions Wholesale2011-01-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-03-11Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralTorrent Pharmaceuticals Limited2009-02-05Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-04-07Not applicableUs
Amlodipine Besylatetablet5 mg/1oralREMEDYREPACK INC.2011-08-22Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralREMEDYREPACK INC.2013-06-14Not applicableUs
Amlodipine Besylatetablet5 mg/1oralDr Reddy's Laboratories2007-07-23Not applicableUs
Amlodipine Besylatetablet5 mg/1oralWockhardt Limited2007-09-06Not applicableUs
Amlodipine Besylatetablet5 mg/1oralRoxane Laboratories, Inc2007-07-09Not applicableUs
Amlodipine Besylatetablet5 mg/1oralApotex Corp.2007-05-24Not applicableUs
Amlodipine Besylatetablet10 mg/1oralRanbaxy Pharmaceuticals Inc2007-07-09Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralAurobindo Pharma Limited2007-07-17Not applicableUs
Amlodipine Besylatetablet5 mg/1oralZydus Pharmaceuticals (USA) Inc.2007-09-21Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAv Pak2011-06-072015-12-29Us
Amlodipine Besylatetablet10 mg/1oralCardinal Health2013-01-20Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralGolden State Medical Supply, Inc.2011-04-25Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralQualitest Pharmaceuticals2010-04-07Not applicableUs
Amlodipine Besylatetablet10 mg/1oralProficient Rx LP2011-01-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-06-21Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralLupin Pharmaceuticals, Inc.2007-08-03Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralExelan Pharmaceuticals, Inc.2007-11-02Not applicableUs
Amlodipine Besylatetablet5 mg/1oralBiomes Pharmaceuticals LLC2011-04-15Not applicableUs
Amlodipine Besylatetablet10 mg/1oralBlenheim Pharmacal, Inc.2012-01-18Not applicableUs
Amlodipine Besylatetablet5 mg/1oralMedsource Pharmaceuticals2014-03-03Not applicableUs
Amlodipine Besylatetablet10 mg/1oralMylan Institutional Inc.2007-04-02Not applicableUs
Amlodipine Besylatetablet5 mg/1oralPhysicians Total Care, Inc.2007-03-28Not applicableUs
Amlodipine Besylatetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralCardinal Health2009-06-10Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2012-10-19Not applicableUs
Amlodipine Besylatetablet10 mg/1oralTeva Pharmaceuticals USA Inc2007-07-10Not applicableUs
Amlodipine Besylatetablet5 mg/1oralREMEDYREPACK INC.2015-02-26Not applicableUs
Amlodipine Besylatetablet10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2007-09-21Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralAscend Laboratories, LLC2010-10-20Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralCipla USA Inc.2007-09-26Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAmerican Health Packaging2013-07-232015-12-29Us
Amlodipine Besylatetablet5 mg/1oralREMEDYREPACK INC.2014-10-202016-04-05Us
Amlodipine Besylatetablet10 mg/1oralUpsher Smith Laboratories, Inc.2007-07-09Not applicableUs
Amlodipine Besylatetablet10 mg/1oralREMEDYREPACK INC.2013-02-272016-04-05Us
Amlodipine Besylatetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2010-10-20Not applicableUs
Amlodipine Besylatetablet5 mg/1oralREMEDYREPACK INC.2013-04-10Not applicableUs
Amlodipine Besylatetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2010-04-07Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralAidarex Pharmaceuticals LLC2011-01-01Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralMajor Pharmaceuticals2013-01-20Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralCamber Pharmaceuticals, Inc.2011-01-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAphena Pharma Solutions Tennessee, Llc2010-04-07Not applicableUs
Amlodipine Besylatetablet5 mg/1oralUnit Dose Services2010-04-07Not applicableUs
Amlodipine Besylatetablet5 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Amlodipine Besylatetablet10 mg/1oralCardinal Health2010-01-14Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralHikma Pharmaceutical2011-04-12Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralMylan Pharmaceuticals Inc.2007-03-23Not applicableUs
Amlodipine Besylatetablet5 mg/1oralDIRECT RX2015-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralTYA Pharmaceuticals2011-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralMc Kesson Contract Packaging2011-09-14Not applicableUs
Amlodipine Besylatetablet10 mg/1oralZydus Pharmaceuticals (USA) Inc.2007-09-21Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAv Pak2011-06-072015-12-29Us
Amlodipine Besylatetablet10 mg/1oralClinical Solutions Wholesale2011-01-01Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2011-03-11Not applicableUs
Amlodipine Besylatetablet5 mg/1oralTorrent Pharmaceuticals Limited2009-02-05Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralEpic Pharma, LLC2011-04-25Not applicableUs
Amlodipine Besylatetablet10 mg/1oralREMEDYREPACK INC.2011-08-22Not applicableUs
Amlodipine Besylatetablet5 mg/1oralREMEDYREPACK INC.2013-12-05Not applicableUs
Amlodipine Besylatetablet10 mg/1oralDr Reddy's Laboratories2007-07-23Not applicableUs
Amlodipine Besylatetablet10 mg/1oralWockhardt Limited2007-09-06Not applicableUs
Amlodipine Besylatetablet10 mg/1oralRoxane Laboratories, Inc2007-07-09Not applicableUs
Amlodipine Besylatetablet10 mg/1oralApotex Corp.2007-05-24Not applicableUs
Amlodipine Besylatetablet10 mg/1oralbryant ranch prepack2007-05-24Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAurobindo Pharma Limited2007-07-17Not applicableUs
Amlodipine Besylatetablet10 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-21Not applicableUs
Amlodipine Besylatetablet10 mg/1oralPhysicians Total Care, Inc.2007-03-28Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCardinal Health2013-01-20Not applicableUs
Amlodipine Besylatetablet5 mg/1oralGolden State Medical Supply, Inc.2011-04-25Not applicableUs
Amlodipine Besylatetablet5 mg/1oralQualitest Pharmaceuticals2010-04-07Not applicableUs
Amlodipine Besylatetablet5 mg/1oralProficient Rx LP2014-03-03Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralCadila Healthcare Limited2007-09-21Not applicableUs
Amlodipine Besylatetablet5 mg/1oralLupin Pharmaceuticals, Inc.2007-08-03Not applicableUs
Amlodipine Besylatetablet5 mg/1oralExelan Pharmaceuticals, Inc.2007-11-02Not applicableUs
Amlodipine Besylatetablet10 mg/1oralBiomes Pharmaceuticals LLC2011-04-15Not applicableUs
Amlodipine Besylatetablet5 mg/1oralBlenheim Pharmacal, Inc.2012-01-18Not applicableUs
Amlodipine Besylatetablet5 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Amlodipine Besylatetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2010-06-21Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralAv Pak2014-01-10Not applicableUs
Amlodipine Besylatetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCardinal Health2011-06-07Not applicableUs
Amlodipine Besylatetablet10 mg/1oralCaraco Pharmaceutical Laboratories, Ltd.2012-10-19Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralWest Ward Pharmaceuticals Corp2011-04-12Not applicableUs
Amlodipine Besylatetablet5 mg/1oralREMEDYREPACK INC.2015-06-19Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralWockhardt USA LLC.2007-09-06Not applicableUs
Amlodipine Besylatetablet5 mg/1oralAscend Laboratories, LLC2010-10-20Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCipla USA Inc.2007-09-26Not applicableUs
Amlodipine Besylatetablet5 mg/1oralLegacy Pharmaceutical Packaging, Llc2011-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralMajor Pharmaceuticals2010-12-03Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralUnichem Pharmaceuticals (USA), Inc.2014-03-03Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAmerican Health Packaging2014-02-03Not applicableUs
Amlodipine Besylatetablet5 mg/1oralMc Kesson Contract Packaging2011-09-14Not applicableUs
Amlodipine Besylatetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2010-04-07Not applicableUs
Amlodipine Besylatetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralMajor Pharmaceuticals2013-01-20Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCamber Pharmaceuticals, Inc.2011-01-01Not applicableUs
Amlodipine Besylatetablet5 mg/1oralSecan Pharmaceuticals Inc.2011-04-15Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralMylan Institutional Inc.2007-04-02Not applicableUs
Amlodipine Besylatetablet10 mg/1oralInternational Labs, Inc.2012-09-14Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralCardinal Health2010-01-14Not applicableUs
Amlodipine Besylatetablet5 mg/1oralHikma Pharmaceutical2011-04-12Not applicableUs
Amlodipine Besylatetablet5 mg/1oralMylan Pharmaceuticals Inc.2007-03-23Not applicableUs
Amlodipine Besylatetablet10 mg/1oralProficient Rx LP2010-04-07Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralAmneal Pharmaceuticals of New York, LLC2010-06-21Not applicableUs
Amlodipine Besylatetablet5 mg/1oralbryant ranch prepack2007-05-24Not applicableUs
Amlodipine Besylatetablet10 mg/1oralAurobindo Pharma Limited2007-07-17Not applicableUs
Amlodipine Besylatetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2015-04-06Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralAmerican Health Packaging2013-07-232015-12-29Us
Amlodipine Besylatetablet5 mg/1oralSt Marys Medical Park Pharmacy2013-04-25Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralUpsher Smith Laboratories, Inc.2007-07-09Not applicableUs
Amlodipine Besylatetablet10 mg/1oralTorrent Pharmaceuticals Limited2009-02-05Not applicableUs
Amlodipine Besylatetablet5 mg/1oralEpic Pharma, LLC2011-04-25Not applicableUs
Amlodipine Besylatetablet10 mg/1oralREMEDYREPACK INC.2011-09-14Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralREMEDYREPACK INC.2013-12-31Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCardinal Health2007-09-06Not applicableUs
Amlodipine Besylatetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-04-07Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralTeva Pharmaceuticals USA Inc2007-07-10Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralREMEDYREPACK INC.2015-03-07Not applicableUs
Amlodipine Besylatetablet5 mg/1oralBlenheim Pharmacal, Inc.2013-11-13Not applicableUs
Amlodipine Besylatetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-11-04Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralREMEDYREPACK INC.2011-04-08Not applicableUs
Amlodipine Besylatetablet5 mg/1oralNorthwind Pharmaceuticals, LLC2014-09-23Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralPhysicians Total Care, Inc.2007-04-06Not applicableUs
Amlodipine Besylatetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2010-06-21Not applicableUs
Amlodipine Besylatetablet10 mg/1oralGolden State Medical Supply, Inc.2011-04-25Not applicableUs
Amlodipine Besylatetablet10 mg/1oralQualitest Pharmaceuticals2010-04-07Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralRanbaxy Pharmaceuticals Inc2007-07-09Not applicableUs
Amlodipine Besylatetablet5 mg/1oralCadila Healthcare Limited2007-09-21Not applicableUs
Amlodipine Besylatetablet10 mg/1oralLupin Pharmaceuticals, Inc.2007-08-03Not applicableUs
Amlodipine Besylatetablet10 mg/1oralExelan Pharmaceuticals, Inc.2007-11-02Not applicableUs
Amlodipine Besylatetablet2.5 mg/1oralUnit Dose Services2011-01-01Not applicableUs
Apo-amlodipinetablet10.0 mgoralApotex Inc2009-07-09Not applicableCanada
Apo-amlodipinetablet2.5 mgoralApotex IncNot applicableNot applicableCanada
Apo-amlodipinetablet5.0 mgoralApotex Inc2009-07-09Not applicableCanada
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AforbesMerck
AgenZentiva
AkenKendrick Farmaceutica
AmcardApex Pharma Ltd
AmdepinCadila Pharmaceuticals
AmdipinLaboratorios Lafrancol
AmlocardAWD (Germany)
AmlodNot Available
AmlodineSumitomo Pharmaceuticals
AmlodipinNot Available
Amlodipin-Mepha 5/10Mepha Pharma AG
Amlodipine 5PT KALBE FARMA Tbk
AmlodisEczacibasi (Turkey)
AmlongMicro Labs
AmlopinLek
AmlopineBerlin
AmlostinDiscovery Pharmaceuticals
AmlosunSun Pharmaceutical
AmlovasMacleods Pharmaceuticals Ltd
AmlovascDr. Reddy's Laboratories
AmlozekAdamed
AmvazReddy (Malaysia)
AsomexEmcure Pharmaceuticals
Atecard-AMAlembic Ltd
CamlodinSquare
CorovalSandoz (Argentina)
DailyvascXeno Pharmaceuticals
IstinNot Available
LamaStadmed Private Limited
LodipTIME Pharmaceuticals
LodopinMerck Pakistan
LopinEdruc Ltd
NelodThe Kemiko Pharmaceuticals Ltd
NopidinAd-din Pharmaceuticals Ltd
NordipNot Available
PerivascNot Available
Pharex AmlodipinePHAREX HealthCorp
TenoxKrka
Brand mixtures
NameLabellerIngredients
AmlobenzRebel Distributors Corp
Amlodipine and Benazepril HydrochlorideTeva Pharmaceuticals USA Inc
Amlodipine and ValsartanTeva Pharmaceuticals USA Inc
Amlodipine Besylate and Atorvastatin CalciumMylan Pharmaceuticals Inc.
Amlodipine Besylate and Benazepril HClAmerican Health Packaging
Amlodipine Besylate and Benazepril HydrochlorideActavis Pharma, Inc.
Amlodipine Besylate and ValsartanMylan Pharmaceuticals Inc.
Amlodipine Besylate/atorvastatin CalciumMylan Pharmaceuticals Inc.
Amlodipine, Valsartan and HydrochlorothiazideTorrent Pharmaceuticals Limited
Amlodipine, Valsartan, and HydrochlorothiazideTeva Pharmaceuticals USA Inc
Amlodipine, Valsartan, HydrochlorothiazideSandoz Inc
AmturnideNovartis Pharmaceuticals Corporation
Apo-amlodipine-atorvastatinApotex Inc
AzorPhysicians Total Care, Inc.
CaduetPfizer Laboratories Div Pfizer Inc
ExforgeNovartis Pharmaceuticals Corporation
Exforge HctNovartis Pharmaceuticals Corporation
Gd-amlodipine/atorvastatinGenmed A Division Of Pfizer Canada Inc
HypertenipinePhysician Therapeutics Llc
LotrelNovartis Pharmaceuticals Corporation
Mylan-amlodipine/atorvastatinMylan Pharmaceuticals Ulc
Pendo-amlodipine-atorvastatinPendopharm Division Of De Pharmascience Inc
PMS-amlodipine-atorvastatinPharmascience Inc
PrestaliaSymplmed Pharmaceuticals, Llc
TekamloNovartis Pharmaceuticals Corporation
Telmisartan and AmlodipineMylan Pharmaceuticals Inc.
TribenzorDaiichi Sankyo, Inc.
TwynstaBoehringer Ingelheim Pharmaceuticals, Inc.
ViacoramServier Canada Inc
Salts
Name/CASStructureProperties
Amlodipine Besilate
ThumbNot applicableDBSALT001054
Amlodipine Besylate
ThumbNot applicableDBSALT001055
Amlodipine Maleate
ThumbNot applicableDBSALT001056
Categories
UNII1J444QC288
CAS number88150-42-9
WeightAverage: 408.876
Monoisotopic: 408.145199627
Chemical FormulaC20H25ClN2O5
InChI KeyHTIQEAQVCYTUBX-UHFFFAOYSA-N
InChI
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
IUPAC Name
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
SMILES
CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. These are compounds containing a dihydropyridine moiety bearing a carboxylic acid group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassHydropyridines
Direct ParentDihydropyridinecarboxylic acids and derivatives
Alternative Parents
Substituents
  • Dihydropyridinecarboxylic acid derivative
  • Halobenzene
  • Chlorobenzene
  • Benzenoid
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl chloride
  • Vinylogous amide
  • Alpha,beta-unsaturated carboxylic ester
  • Enoate ester
  • Methyl ester
  • Carboxylic acid ester
  • Azacycle
  • Ether
  • Enamine
  • Dialkyl ether
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of hypertension and chronic stable angina.
PharmacodynamicsAmlodipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. There are at least five different types of calcium channels in Homo sapiens: L-, N-, P/Q-, R- and T-type. It was widely accepted that DHP CCBs target L-type calcium channels, the major channel in muscle cells that mediate contraction; however, some studies have indicated that amlodipine also binds to and inhibits N-type calcium channels (see references in Targets section). Similar to other DHP CCBs, amlodipine binds directly to inactive L-type calcium channels stabilizing their inactive conformation. Since arterial smooth muscle depolarizations are longer in duration than cardiac muscle depolarizations, inactive channels are more prevalent in smooth muscle cells. Alternative splicing of the alpha-1 subunit of the channel gives amlodipine additional arterial selectivity. At therapeutic sub-toxic concentrations, amlodipine has little effect on cardiac myocytes and conduction cells.
Mechanism of actionAmlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracelluar calcium influx through calcium channels.
Related Articles
AbsorptionAmlodipine is slowly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached 6-12 hour following oral administration. Its estimated bioavailability is 64-90%. Absorption is not affected by food.
Volume of distributionNot Available
Protein binding97.5%
Metabolism

Hepatic. Metabolized extensively (90%) to inactive metabolites via the cytochrome P450 3A4 isozyme.

Route of eliminationAmlodipine is extensively (about 90%) converted to inactive metabolites via hepatic metabolism with 10% of the parent compound and 60% of the metabolites excreted in the urine.
Half life30-50 hours
ClearanceNot Available
ToxicityGross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Amlodipine Action PathwayDrug actionSMP00376
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Natriuretic peptides A
Gene symbol: NPPA
UniProt: P01160
rs5065 Not AvailableAA alleleThose with the rs5065(AA) allele had more favorable cardiovascular disease outcomes if given amlodipine than if treated with chlorthalidone (diuretic)18212314
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9479
Blood Brain Barrier-0.7744
Caco-2 permeable-0.5468
P-glycoprotein substrateSubstrate0.9102
P-glycoprotein inhibitor IInhibitor0.8564
P-glycoprotein inhibitor IINon-inhibitor0.8473
Renal organic cation transporterNon-inhibitor0.803
CYP450 2C9 substrateNon-substrate0.8627
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6967
CYP450 1A2 substrateInhibitor0.538
CYP450 2C9 inhibitorInhibitor0.514
CYP450 2D6 inhibitorNon-inhibitor0.7626
CYP450 2C19 inhibitorInhibitor0.5871
CYP450 3A4 inhibitorInhibitor0.8608
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6642
Ames testNon AMES toxic0.7605
CarcinogenicityNon-carcinogens0.8568
BiodegradationNot ready biodegradable0.9791
Rat acute toxicity2.5396 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8302
hERG inhibition (predictor II)Inhibitor0.8411
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Synthon pharmaceuticals inc
  • Actavis totowa llc
  • Alkem laboratories ltd
  • Amneal pharmaceuticals ny llc
  • Apotex inc
  • Aurobindo pharma ltd
  • Caraco pharmaceutical laboratories ltd
  • Dr reddys laboratories ltd
  • Gedeon richter usa inc
  • Genpharm inc
  • Glenmark generics ltd
  • Invagen pharmaceuticals inc
  • Lek pharmaceuticals dd
  • Lupin ltd
  • Matrix laboratories ltd
  • Mutual pharmacal co
  • Mylan laboratories inc
  • Orchid healthcare
  • Ranbaxy laboratories ltd
  • Roxane laboratories inc
  • Teva pharmaceuticals usa inc
  • Torrent pharmaceuticals ltd
  • Upsher smith laboratories inc
  • Vintage pharmaceuticals llc
  • Watson laboratories inc
  • Wockhardt ltd
  • World gen llc
  • Zydus pharmaceuticals usa inc
  • Pfizer inc
  • Dr reddys laboratories inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 mg/1
Tabletoral2.5 mg/1
Tabletoral5 mg/1
Tabletoral10.00 mg
Tabletoral5.00 mg
Tablet, film coatedoral
Tabletoral2.5 mg
Kit
Capsuleoral
Tabletoral10.0 mg
Tabletoral5.0 mg
Tabletoral10 mg
Tabletoral5 mg
Tabletoral
Tablet, multilayeroral
Prices
Unit descriptionCostUnit
Amlodipine besylate powder9.99USD g
Lotrel 10-40 mg capsule5.21USD capsule
Lotrel 10-20 mg capsule4.8USD capsule
Lotrel 5-40 mg capsule4.37USD capsule
Lotrel 5-20 mg capsule4.13USD capsule
Lotrel 5-10 mg capsule3.91USD capsule
Lotrel 2.5-10 mg capsule3.83USD capsule
Norvasc 10 mg tablet3.16USD tablet
Amlodipine besylate 10 mg tablet2.42USD tablet
Norvasc 2.5 mg tablet2.36USD tablet
Norvasc 5 mg tablet2.36USD tablet
Norvasc 10 mg Tablet2.14USD tablet
Amlodipine besylate 2.5 mg tablet1.76USD tablet
Amlodipine besylate 5 mg tablet1.76USD tablet
Norvasc 5 mg Tablet1.44USD tablet
Amlodipine 10 mg Tablet1.03USD tablet
Apo-Amlodipine 10 mg Tablet1.03USD tablet
Co Amlodipine 10 mg Tablet1.03USD tablet
Gd-Amlodipine 10 mg Tablet1.03USD tablet
Jamp-Amlodipine 10 mg Tablet1.03USD tablet
Mylan-Amlodipine 10 mg Tablet1.03USD tablet
Novo-Amlodipine 10 mg Tablet1.03USD tablet
Phl-Amlodipine 10 mg Tablet1.03USD tablet
Pms-Amlodipine 10 mg Tablet1.03USD tablet
Ran-Amlodipine 10 mg Tablet1.03USD tablet
Ratio-Amlodipine 10 mg Tablet1.03USD tablet
Sandoz Amlodipine 10 mg Tablet1.03USD tablet
Amlodipine 5 mg Tablet0.7USD tablet
Apo-Amlodipine 5 mg Tablet0.7USD tablet
Co Amlodipine 5 mg Tablet0.7USD tablet
Gd-Amlodipine 5 mg Tablet0.7USD tablet
Jamp-Amlodipine 5 mg Tablet0.7USD tablet
Mylan-Amlodipine 5 mg Tablet0.7USD tablet
Novo-Amlodipine 5 mg Tablet0.7USD tablet
Phl-Amlodipine 5 mg Tablet0.7USD tablet
Pms-Amlodipine 5 mg Tablet0.7USD tablet
Ran-Amlodipine 5 mg Tablet0.7USD tablet
Ratio-Amlodipine 5 mg Tablet0.7USD tablet
Sandoz Amlodipine 5 mg Tablet0.7USD tablet
Phl-Amlodipine 2.5 mg Tablet0.35USD tablet
Pms-Amlodipine 2.5 mg Tablet0.35USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2170278 No1999-08-032014-08-10Canada
US5559111 No1998-07-212018-07-21Us
US5616599 Yes1996-10-252016-10-25Us
US5969156 Yes1997-01-082017-01-08Us
US6162802 No1997-12-192017-12-19Us
US6294197 Yes1997-12-182017-12-18Us
US6395728 No1999-07-082019-07-08Us
US6455574 No1998-08-112018-08-11Us
US6696481 No2003-04-152023-04-15Us
US6828339 No2002-11-202022-11-20Us
US7846961 No2009-10-052029-10-05Us
US8101599 No2003-05-162023-05-16Us
US8183295 No2003-05-162023-05-16Us
US8475839 Yes2003-11-162023-11-16Us
US8613949 No2009-12-212029-12-21Us
US8618174 No2001-11-152021-11-15Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point178-179 °CNot Available
water solubility75.3 mg/LNot Available
logP3.00AUSTIN,RP ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0074 mg/mLALOGPS
logP2.22ALOGPS
logP1.64ChemAxon
logS-4.7ALOGPS
pKa (Strongest Basic)9.45ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area99.88 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity108.64 m3·mol-1ChemAxon
Polarizability42.29 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

DrugSyn.org

US4572909
General References
  1. Nayler WG, Gu XH: The unique binding properties of amlodipine: a long-acting calcium antagonist. J Hum Hypertens. 1991 Aug;5 Suppl 1:55-9. [PubMed:1834847 ]
  2. van Zwieten PA: Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties. Clin Cardiol. 1994 Sep;17(9 Suppl 3):III3-6. [PubMed:9156957 ]
External Links
ATC CodesC09DB05C09DX03C09DB04C09DB01C09DX01C10BX03C09DB02C09DB07C09DB06C10BX11C08GA02C08CA01C09BB07C09BB03C10BX09C09BB04C09XA54C09XA53C10BX07C09BX01
AHFS Codes
  • 24:28.08
PDB Entries
FDA labelDownload (91.4 KB)
MSDSDownload (74.5 KB)
Interactions
Drug Interactions
Drug
2-HYDROXY-1,4-NAPHTHOQUINONEThe risk or severity of adverse effects can be increased when 2-HYDROXY-1,4-NAPHTHOQUINONE is combined with Amlodipine.
2-mercaptobenzothiazoleThe risk or severity of adverse effects can be increased when 2-mercaptobenzothiazole is combined with Amlodipine.
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Amlodipine.
AcebutololAmlodipine may increase the hypotensive activities of Acebutolol.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Amlodipine.
AcetazolamideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Acetazolamide.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Amlodipine.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Amlodipine.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Amlodipine.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Amlodipine.
AlfuzosinAlfuzosin may increase the hypotensive activities of Amlodipine.
AliskirenAmlodipine may increase the hypotensive activities of Aliskiren.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Amlodipine.
AlprenololAmlodipine may increase the hypotensive activities of Alprenolol.
AmbrisentanAmlodipine may increase the hypotensive activities of Ambrisentan.
AmifostineAmlodipine may increase the hypotensive activities of Amifostine.
AmilorideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Amiloride.
AmiodaroneThe metabolism of Amlodipine can be decreased when combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Amlodipine.
AmobarbitalAmobarbital may increase the hypotensive activities of Amlodipine.
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Amlodipine.
AmorolfineThe risk or severity of adverse effects can be increased when Amorolfine is combined with Amlodipine.
Amphotericin BThe risk or severity of adverse effects can be increased when Amphotericin B is combined with Amlodipine.
Amyl NitriteThe risk or severity of adverse effects can be increased when Amlodipine is combined with Amyl Nitrite.
AN2690The risk or severity of adverse effects can be increased when AN2690 is combined with Amlodipine.
AnidulafunginThe risk or severity of adverse effects can be increased when Anidulafungin is combined with Amlodipine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Amlodipine.
ApraclonidineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Apraclonidine.
AprepitantThe serum concentration of Amlodipine can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Amlodipine.
AripiprazoleAripiprazole may increase the hypotensive activities of Amlodipine.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Amlodipine.
ArtemetherThe risk or severity of adverse effects can be increased when Artemether is combined with Amlodipine.
ArtesunateThe serum concentration of the active metabolites of Artesunate can be reduced when Artesunate is used in combination with Amlodipine resulting in a loss in efficacy.
AtazanavirThe metabolism of Amlodipine can be decreased when combined with Atazanavir.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Amlodipine.
AtenololAtenolol may increase the hypotensive activities of Amlodipine.
AtomoxetineThe metabolism of Amlodipine can be decreased when combined with Atomoxetine.
AtosibanThe risk or severity of adverse effects can be increased when Amlodipine is combined with Atosiban.
Atracurium besylateAmlodipine may increase the neuromuscular blocking activities of Atracurium besylate.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Amlodipine.
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Amlodipine is combined with Azilsartan medoxomil.
Bafilomycin A1The risk or severity of adverse effects can be increased when Bafilomycin A1 is combined with Amlodipine.
BarbitalBarbital may increase the hypotensive activities of Amlodipine.
BenazeprilAmlodipine may increase the hypotensive activities of Benazepril.
BendroflumethiazideAmlodipine may increase the hypotensive activities of Bendroflumethiazide.
BenmoxinBenmoxin may increase the hypotensive activities of Amlodipine.
Benzoic AcidThe risk or severity of adverse effects can be increased when Benzoic Acid is combined with Amlodipine.
BepridilAmlodipine may increase the hypotensive activities of Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Amlodipine.
BetaxololBetaxolol may increase the hypotensive activities of Amlodipine.
BethanidineBethanidine may increase the hypotensive activities of Amlodipine.
BexaroteneThe serum concentration of Amlodipine can be decreased when it is combined with Bexarotene.
BifonazoleThe risk or severity of adverse effects can be increased when Bifonazole is combined with Amlodipine.
BimatoprostAmlodipine may increase the hypotensive activities of Bimatoprost.
BisoprololAmlodipine may increase the hypotensive activities of Bisoprolol.
BoceprevirThe metabolism of Amlodipine can be decreased when combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Amlodipine.
BortezomibThe metabolism of Amlodipine can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Amlodipine can be decreased when it is combined with Bosentan.
BosentanAmlodipine may increase the hypotensive activities of Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Amlodipine.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Amlodipine.
BretyliumAmlodipine may increase the hypotensive activities of Bretylium.
BrimonidineAmlodipine may increase the hypotensive activities of Brimonidine.
BrimonidineBrimonidine may increase the antihypertensive activities of Amlodipine.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Amlodipine.
BumetanideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Bumetanide.
BupranololAmlodipine may increase the hypotensive activities of Bupranolol.
ButenafineThe risk or severity of adverse effects can be increased when Butenafine is combined with Amlodipine.
ButoconazoleThe risk or severity of adverse effects can be increased when Butoconazole is combined with Amlodipine.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Amlodipine.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Amlodipine.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Amlodipine.
CanagliflozinThe risk or severity of adverse effects can be increased when Amlodipine is combined with Canagliflozin.
CandesartanAmlodipine may increase the hypotensive activities of Candesartan.
CandicidinThe risk or severity of adverse effects can be increased when Candicidin is combined with Amlodipine.
CandoxatrilAmlodipine may increase the hypotensive activities of Candoxatril.
CaptoprilAmlodipine may increase the hypotensive activities of Captopril.
CarbamazepineThe metabolism of Amlodipine can be increased when combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Amlodipine.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Amlodipine.
CaroxazoneCaroxazone may increase the hypotensive activities of Amlodipine.
CarteololAmlodipine may increase the hypotensive activities of Carteolol.
CarvedilolAmlodipine may increase the hypotensive activities of Carvedilol.
CaspofunginThe risk or severity of adverse effects can be increased when Caspofungin is combined with Amlodipine.
CeliprololAmlodipine may increase the hypotensive activities of Celiprolol.
CeritinibThe serum concentration of Amlodipine can be increased when it is combined with Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Amlodipine.
CeruleninThe risk or severity of adverse effects can be increased when Cerulenin is combined with Amlodipine.
ChlorothiazideAmlodipine may increase the hypotensive activities of Chlorothiazide.
ChloroxineThe risk or severity of adverse effects can be increased when Chloroxine is combined with Amlodipine.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Amlodipine.
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Amlodipine.
CiclopiroxThe risk or severity of adverse effects can be increased when Ciclopirox is combined with Amlodipine.
CilazaprilAmlodipine may increase the hypotensive activities of Cilazapril.
CimetidineThe serum concentration of Amlodipine can be increased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Amlodipine.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Amlodipine.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Amlodipine.
ClarithromycinThe metabolism of Amlodipine can be decreased when combined with Clarithromycin.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Amlodipine.
ClemastineThe metabolism of Amlodipine can be decreased when combined with Clemastine.
ClevidipineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Clevidipine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Amlodipine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Amlodipine.
ClonidineAmlodipine may increase the hypotensive activities of Clonidine.
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Amlodipine.
ClotrimazoleThe metabolism of Amlodipine can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Amlodipine.
CobicistatThe metabolism of Amlodipine can be decreased when combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Amlodipine.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Amlodipine.
ConivaptanThe serum concentration of Amlodipine can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Amlodipine.
CrizotinibThe metabolism of Amlodipine can be decreased when combined with Crizotinib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Amlodipine.
CryptenamineAmlodipine may increase the hypotensive activities of Cryptenamine.
CyclosporineThe metabolism of Amlodipine can be decreased when combined with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Amlodipine.
CyclothiazideAmlodipine may increase the hypotensive activities of Cyclothiazide.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Amlodipine.
DabrafenibThe serum concentration of Amlodipine can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Amlodipine.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Amlodipine.
DapagliflozinThe risk or severity of adverse effects can be increased when Amlodipine is combined with Dapagliflozin.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Amlodipine.
DarunavirThe metabolism of Amlodipine can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Amlodipine can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Amlodipine.
DebrisoquinAmlodipine may increase the hypotensive activities of Debrisoquin.
Decanoic AcidThe risk or severity of adverse effects can be increased when Decanoic Acid is combined with Amlodipine.
DeferasiroxThe serum concentration of Amlodipine can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Amlodipine can be decreased when combined with Delavirdine.
DeserpidineAmlodipine may increase the hypotensive activities of Deserpidine.
DexamethasoneThe serum concentration of Amlodipine can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Amlodipine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Dexmedetomidine.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Amlodipine.
DiazoxideDiazoxide may increase the hypotensive activities of Amlodipine.
DiclofenamideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Diclofenamide.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Amlodipine.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Amlodipine.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Amlodipine.
DihydroergotamineThe metabolism of Amlodipine can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Amlodipine.
DiltiazemDiltiazem may increase the hypotensive activities of Amlodipine.
DinutuximabThe risk or severity of adverse effects can be increased when Amlodipine is combined with Dinutuximab.
DipyridamoleThe risk or severity of adverse effects can be increased when Amlodipine is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Amlodipine.
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Amlodipine.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Amlodipine.
DorzolamideAmlodipine may increase the hypotensive activities of Dorzolamide.
DoxazosinAmlodipine may increase the hypotensive activities of Doxazosin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Amlodipine.
DoxycyclineThe metabolism of Amlodipine can be decreased when combined with Doxycycline.
DronedaroneThe metabolism of Amlodipine can be decreased when combined with Dronedarone.
DuloxetineAmlodipine may increase the orthostatic hypotensive activities of Duloxetine.
EconazoleThe risk or severity of adverse effects can be increased when Econazole is combined with Amlodipine.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Amlodipine.
EfavirenzThe serum concentration of Amlodipine can be decreased when it is combined with Efavirenz.
EfinaconazoleThe risk or severity of adverse effects can be increased when Efinaconazole is combined with Amlodipine.
EfonidipineAmlodipine may increase the hypotensive activities of Efonidipine.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Amlodipine.
EmpagliflozinThe risk or severity of adverse effects can be increased when Amlodipine is combined with Empagliflozin.
EnalaprilAmlodipine may increase the hypotensive activities of Enalapril.
EnalaprilatAmlodipine may increase the hypotensive activities of Enalaprilat.
EnzalutamideThe serum concentration of Amlodipine can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Amlodipine.
EplerenoneThe risk or severity of adverse effects can be increased when Amlodipine is combined with Eplerenone.
EpoprostenolAmlodipine may increase the hypotensive activities of Epoprostenol.
EprosartanAmlodipine may increase the hypotensive activities of Eprosartan.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Amlodipine.
ErythromycinThe metabolism of Amlodipine can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Amlodipine.
Eslicarbazepine acetateThe serum concentration of Amlodipine can be decreased when it is combined with Eslicarbazepine acetate.
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Amlodipine.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Amlodipine.
EstriolThe serum concentration of Estriol can be increased when it is combined with Amlodipine.
EstroneThe serum concentration of Estrone can be increased when it is combined with Amlodipine.
Etacrynic acidThe risk or severity of adverse effects can be increased when Amlodipine is combined with Etacrynic acid.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Amlodipine.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Amlodipine.
EtravirineThe serum concentration of Amlodipine can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Amlodipine.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Amlodipine.
FelodipineAmlodipine may increase the hypotensive activities of Felodipine.
FenoldopamAmlodipine may increase the hypotensive activities of Fenoldopam.
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Amlodipine.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Amlodipine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Amlodipine.
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Amlodipine.
FluconazoleThe serum concentration of Amlodipine can be increased when it is combined with Fluconazole.
FlucytosineThe risk or severity of adverse effects can be increased when Flucytosine is combined with Amlodipine.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Amlodipine.
FluvoxamineThe metabolism of Amlodipine can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Amlodipine can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Amlodipine can be increased when it is combined with Fosaprepitant.
FosinoprilAmlodipine may increase the hypotensive activities of Fosinopril.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Amlodipine.
FosphenytoinThe metabolism of Amlodipine can be increased when combined with Fosphenytoin.
FurazolidoneFurazolidone may increase the hypotensive activities of Amlodipine.
FurosemideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Furosemide.
Fusidic AcidThe serum concentration of Amlodipine can be increased when it is combined with Fusidic Acid.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Amlodipine.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Amlodipine.
GlyphosateThe risk or severity of adverse effects can be increased when Glyphosate is combined with Amlodipine.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Amlodipine.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Amlodipine.
GriseofulvinThe risk or severity of adverse effects can be increased when Griseofulvin is combined with Amlodipine.
GuanabenzAmlodipine may increase the hypotensive activities of Guanabenz.
GuanadrelGuanadrel may increase the hypotensive activities of Amlodipine.
GuanethidineAmlodipine may increase the hypotensive activities of Guanethidine.
GuanfacineAmlodipine may increase the hypotensive activities of Guanfacine.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Amlodipine.
HaloproginThe risk or severity of adverse effects can be increased when Haloprogin is combined with Amlodipine.
HexamethoniumAmlodipine may increase the hypotensive activities of Hexamethonium.
HexetidineThe risk or severity of adverse effects can be increased when Hexetidine is combined with Amlodipine.
HexobarbitalHexobarbital may increase the hypotensive activities of Amlodipine.
HydracarbazineHydracarbazine may increase the hypotensive activities of Amlodipine.
HydralazineAmlodipine may increase the hypotensive activities of Hydralazine.
HydrochlorothiazideAmlodipine may increase the hypotensive activities of Hydrochlorothiazide.
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Amlodipine.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Amlodipine.
HydroflumethiazideAmlodipine may increase the hypotensive activities of Hydroflumethiazide.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Amlodipine.
IdelalisibThe serum concentration of Amlodipine can be increased when it is combined with Idelalisib.
IloprostIloprost may increase the hypotensive activities of Amlodipine.
ImatinibThe metabolism of Amlodipine can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Amlodipine.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Amlodipine.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Amlodipine.
IndapamideAmlodipine may increase the hypotensive activities of Indapamide.
IndenololAmlodipine may increase the hypotensive activities of Indenolol.
IndinavirThe metabolism of Amlodipine can be decreased when combined with Indinavir.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Amlodipine.
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Amlodipine.
IndoraminAmlodipine may increase the hypotensive activities of Indoramin.
IproclozideIproclozide may increase the hypotensive activities of Amlodipine.
IproniazidIproniazid may increase the hypotensive activities of Amlodipine.
IrbesartanAmlodipine may increase the hypotensive activities of Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Amlodipine.
IsavuconazoniumThe metabolism of Amlodipine can be decreased when combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Amlodipine.
IsoconazoleThe risk or severity of adverse effects can be increased when Isoconazole is combined with Amlodipine.
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Amlodipine is combined with Isosorbide Dinitrate.
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Amlodipine is combined with Isosorbide Mononitrate.
IsoxsuprineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Isoxsuprine.
IsradipineIsradipine may increase the hypotensive activities of Amlodipine.
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Amlodipine.
IvacaftorThe serum concentration of Amlodipine can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Amlodipine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Amlodipine.
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Amlodipine.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Amlodipine.
LabetalolAmlodipine may increase the hypotensive activities of Labetalol.
LacidipineAmlodipine may increase the hypotensive activities of Lacidipine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Amlodipine.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Amlodipine.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Amlodipine.
LatanoprostAmlodipine may increase the hypotensive activities of Latanoprost.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Amlodipine.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Amlodipine.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Amlodipine.
LercanidipineAmlodipine may increase the hypotensive activities of Lercanidipine.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Amlodipine.
LevobunololThe risk or severity of adverse effects can be increased when Amlodipine is combined with Levobunolol.
LevodopaAmlodipine may increase the orthostatic hypotensive activities of Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Amlodipine.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Amlodipine.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Amlodipine.
LisinoprilAmlodipine may increase the hypotensive activities of Lisinopril.
LofexidineAmlodipine may increase the hypotensive activities of Lofexidine.
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Amlodipine.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Amlodipine.
LopinavirThe metabolism of Amlodipine can be decreased when combined with Lopinavir.
LosartanAmlodipine may increase the hypotensive activities of Losartan.
LovastatinThe metabolism of Amlodipine can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Amlodipine can be increased when it is combined with Luliconazole.
MacitentanAmlodipine may increase the hypotensive activities of Macitentan.
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Magnesium hydroxide.
Magnesium oxideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Magnesium oxide.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Amlodipine is combined with Magnesium salicylate.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Amlodipine is combined with Magnesium Sulfate.
ManidipineAmlodipine may increase the hypotensive activities of Manidipine.
MannitolThe risk or severity of adverse effects can be increased when Amlodipine is combined with Mannitol.
MebanazineMebanazine may increase the hypotensive activities of Amlodipine.
MecamylamineAmlodipine may increase the hypotensive activities of Mecamylamine.
MethazolamideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Methazolamide.
MethohexitalMethohexital may increase the hypotensive activities of Amlodipine.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Amlodipine.
MethyclothiazideThe risk or severity of adverse effects can be increased when Methyclothiazide is combined with Amlodipine.
MethyldopaAmlodipine may increase the hypotensive activities of Methyldopa.
Methylene blueMethylene blue may increase the hypotensive activities of Amlodipine.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Amlodipine.
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Amlodipine.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Amlodipine.
MetipranololAmlodipine may increase the hypotensive activities of Metipranolol.
MetolazoneAmlodipine may increase the hypotensive activities of Metolazone.
MetoprololMetoprolol may increase the hypotensive activities of Amlodipine.
MevastatinThe risk or severity of adverse effects can be increased when Mevastatin is combined with Amlodipine.
MibefradilAmlodipine may increase the hypotensive activities of Mibefradil.
MicafunginThe risk or severity of adverse effects can be increased when Micafungin is combined with Amlodipine.
MiconazoleThe risk or severity of adverse effects can be increased when Miconazole is combined with Amlodipine.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Amlodipine.
MifepristoneThe metabolism of Amlodipine can be decreased when combined with Mifepristone.
MiltefosineThe risk or severity of adverse effects can be increased when Miltefosine is combined with Amlodipine.
MinaprineMinaprine may increase the hypotensive activities of Amlodipine.
MinoxidilMinoxidil may increase the hypotensive activities of Amlodipine.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Amlodipine.
MitotaneThe serum concentration of Amlodipine can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Amlodipine.
MivacuriumAmlodipine may increase the neuromuscular blocking activities of Mivacurium.
MoclobemideMoclobemide may increase the hypotensive activities of Amlodipine.
ModafinilThe serum concentration of Amlodipine can be decreased when it is combined with Modafinil.
MoexiprilAmlodipine may increase the hypotensive activities of Moexipril.
MolsidomineMolsidomine may increase the hypotensive activities of Amlodipine.
MonensinThe risk or severity of adverse effects can be increased when Monensin is combined with Amlodipine.
MorphineThe serum concentration of Morphine can be increased when it is combined with Amlodipine.
MoxonidineAmlodipine may increase the hypotensive activities of Moxonidine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Amlodipine.
MyxothiazolThe risk or severity of adverse effects can be increased when Myxothiazol is combined with Amlodipine.
NadololAmlodipine may increase the hypotensive activities of Nadolol.
NafcillinThe serum concentration of Amlodipine can be decreased when it is combined with Nafcillin.
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Amlodipine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Amlodipine.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Amlodipine.
NatamycinThe risk or severity of adverse effects can be increased when Natamycin is combined with Amlodipine.
NebivololAmlodipine may increase the hypotensive activities of Nebivolol.
NefazodoneThe metabolism of Amlodipine can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Amlodipine can be decreased when combined with Nelfinavir.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Amlodipine.
NesiritideThe risk or severity of adverse effects can be increased when Amlodipine is combined with Nesiritide.
NetupitantThe serum concentration of Amlodipine can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Amlodipine can be decreased when combined with Nevirapine.
NialamideNialamide may increase the hypotensive activities of Amlodipine.
NicardipineAmlodipine may increase the hypotensive activities of Nicardipine.
NicorandilNicorandil may increase the hypotensive activities of Amlodipine.
NifedipineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Nifedipine.
NiguldipineAmlodipine may increase the hypotensive activities of Niguldipine.
NilotinibThe metabolism of Amlodipine can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Amlodipine.
NilvadipineAmlodipine may increase the hypotensive activities of Nilvadipine.
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Amlodipine.
NimodipineNimodipine may increase the hypotensive activities of Amlodipine.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Amlodipine.
NisoldipineAmlodipine may increase the hypotensive activities of Nisoldipine.
NitrendipineAmlodipine may increase the hypotensive activities of Nitrendipine.
NitroglycerinThe risk or severity of adverse effects can be increased when Amlodipine is combined with Nitroglycerin.
NitroprussideAmlodipine may increase the hypotensive activities of Nitroprusside.
NitroxolineThe risk or severity of adverse effects can be increased when Nitroxoline is combined with Amlodipine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Amlodipine.
NystatinThe risk or severity of adverse effects can be increased when Nystatin is combined with Amlodipine.
ObinutuzumabAmlodipine may increase the hypotensive activities of Obinutuzumab.
OctamoxinOctamoxin may increase the hypotensive activities of Amlodipine.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Amlodipine.
OlaparibThe metabolism of Amlodipine can be decreased when combined with Olaparib.
OlmesartanOlmesartan may increase the hypotensive activities of Amlodipine.
OmapatrilatAmlodipine may increase the hypotensive activities of Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Amlodipine.
OsimertinibThe serum concentration of Amlodipine can be increased when it is combined with Osimertinib.
OxiconazoleThe risk or severity of adverse effects can be increased when Oxiconazole is combined with Amlodipine.
OxprenololAmlodipine may increase the hypotensive activities of Oxprenolol.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Amlodipine.
pafuramidineThe risk or severity of adverse effects can be increased when pafuramidine is combined with Amlodipine.
PalbociclibThe serum concentration of Amlodipine can be increased when it is combined with Palbociclib.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Amlodipine.
PapaverineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Papaverine.
PargylineAmlodipine may increase the hypotensive activities of Pargyline.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Amlodipine.
PenbutololAmlodipine may increase the hypotensive activities of Penbutolol.
PentamidineThe risk or severity of adverse effects can be increased when Pentamidine is combined with Amlodipine.
PentobarbitalPentobarbital may increase the hypotensive activities of Amlodipine.
PentoliniumAmlodipine may increase the hypotensive activities of Pentolinium.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Amlodipine.
PerindoprilAmlodipine may increase the hypotensive activities of Perindopril.
PhenelzinePhenelzine may increase the hypotensive activities of Amlodipine.
PheniprazinePheniprazine may increase the hypotensive activities of Amlodipine.
PhenobarbitalPhenobarbital may increase the hypotensive activities of Amlodipine.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Amlodipine.
PhenoxybenzamineAmlodipine may increase the hypotensive activities of Phenoxybenzamine.
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Amlodipine.
PhentolamineAmlodipine may increase the hypotensive activities of Phentolamine.
PhenytoinThe metabolism of Amlodipine can be increased when combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Amlodipine.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Amlodipine.
PinacidilAmlodipine may increase the hypotensive activities of Pinacidil.
PindololAmlodipine may increase the hypotensive activities of Pindolol.
PirlindolePirlindole may increase the hypotensive activities of Amlodipine.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Amlodipine.
PivhydrazinePivhydrazine may increase the hypotensive activities of Amlodipine.
PolythiazideAmlodipine may increase the hypotensive activities of Polythiazide.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Amlodipine.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Amlodipine.
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Amlodipine.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Amlodipine.
PrazosinAmlodipine may increase the hypotensive activities of Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Amlodipine.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Amlodipine.
PrimidonePrimidone may increase the hypotensive activities of Amlodipine.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Amlodipine.
PropranololAmlodipine may increase the hypotensive activities of Propranolol.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Amlodipine.
QuetiapineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Quetiapine.
QuinaprilAmlodipine may increase the hypotensive activities of Quinapril.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Amlodipine.
QuinineQuinine may increase the hypotensive activities of Amlodipine.
QuinineThe serum concentration of Quinine can be increased when it is combined with Amlodipine.
RadicicolThe risk or severity of adverse effects can be increased when Radicicol is combined with Amlodipine.
RamiprilRamipril may increase the hypotensive activities of Amlodipine.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Amlodipine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Amlodipine.
RanolazineThe metabolism of Amlodipine can be decreased when combined with Ranolazine.
RapacuroniumAmlodipine may increase the neuromuscular blocking activities of Rapacuronium.
RasagilineRasagiline may increase the hypotensive activities of Amlodipine.
RemikirenRemikiren may increase the hypotensive activities of Amlodipine.
RescinnamineAmlodipine may increase the hypotensive activities of Rescinnamine.
ReserpineReserpine may increase the hypotensive activities of Amlodipine.
RifabutinThe metabolism of Amlodipine can be increased when combined with Rifabutin.
RifampicinThe metabolism of Amlodipine can be increased when combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Amlodipine.
RifapentineThe metabolism of Amlodipine can be increased when combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Amlodipine.
RiociguatAmlodipine may increase the hypotensive activities of Riociguat.
RisperidoneAmlodipine may increase the hypotensive activities of Risperidone.
RitonavirThe metabolism of Amlodipine can be decreased when combined with Ritonavir.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Amlodipine.
RituximabAmlodipine may increase the hypotensive activities of Rituximab.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Amlodipine.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Amlodipine.
SafrazineSafrazine may increase the hypotensive activities of Amlodipine.
Salicylhydroxamic AcidThe risk or severity of adverse effects can be increased when Salicylhydroxamic Acid is combined with Amlodipine.
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Amlodipine.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Amlodipine.
SaprisartanAmlodipine may increase the hypotensive activities of Saprisartan.
SaquinavirThe metabolism of Amlodipine can be decreased when combined with Saquinavir.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Amlodipine.
SecobarbitalSecobarbital may increase the hypotensive activities of Amlodipine.
SelegilineSelegiline may increase the hypotensive activities of Amlodipine.
SelexipagAmlodipine may increase the hypotensive activities of Selexipag.
SertaconazoleThe risk or severity of adverse effects can be increased when Sertaconazole is combined with Amlodipine.
SildenafilSildenafil may increase the antihypertensive activities of Amlodipine.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Amlodipine.
SilodosinSilodosin may increase the hypotensive activities of Amlodipine.
SiltuximabThe serum concentration of Amlodipine can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Amlodipine can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Amlodipine.
SinefunginThe risk or severity of adverse effects can be increased when Sinefungin is combined with Amlodipine.
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Amlodipine.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Amlodipine.
SitaxentanAmlodipine may increase the hypotensive activities of Sitaxentan.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Amlodipine.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Amlodipine.
SotalolThe risk or severity of adverse effects can be increased when Amlodipine is combined with Sotalol.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Amlodipine.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Amlodipine.
SpiraprilAmlodipine may increase the hypotensive activities of Spirapril.
SpironolactoneThe risk or severity of adverse effects can be increased when Amlodipine is combined with Spironolactone.
St. John's WortThe serum concentration of Amlodipine can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Amlodipine can be increased when it is combined with Stiripentol.
SulconazoleThe risk or severity of adverse effects can be increased when Sulconazole is combined with Amlodipine.
SulfisoxazoleThe metabolism of Amlodipine can be decreased when combined with Sulfisoxazole.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Amlodipine.
TadalafilTadalafil may increase the antihypertensive activities of Amlodipine.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Amlodipine.
TamsulosinTamsulosin may increase the hypotensive activities of Amlodipine.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Amlodipine.
TavaboroleThe risk or severity of adverse effects can be increased when Tavaborole is combined with Amlodipine.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Amlodipine.
TelaprevirThe metabolism of Amlodipine can be decreased when combined with Telaprevir.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Amlodipine.
TelithromycinThe metabolism of Amlodipine can be decreased when combined with Telithromycin.
TelmisartanAmlodipine may increase the hypotensive activities of Telmisartan.
TemocaprilAmlodipine may increase the hypotensive activities of Temocapril.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Amlodipine.
TerazosinTerazosin may increase the hypotensive activities of Amlodipine.
TerazosinThe risk or severity of adverse effects can be increased when Amlodipine is combined with Terazosin.
TerbinafineThe risk or severity of adverse effects can be increased when Terbinafine is combined with Amlodipine.
TerconazoleThe risk or severity of adverse effects can be increased when Terconazole is combined with Amlodipine.
TerlipressinAmlodipine may increase the hypotensive activities of Terlipressin.
ThiamylalThiamylal may increase the hypotensive activities of Amlodipine.
ThiopentalThiopental may increase the hypotensive activities of Amlodipine.
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Amlodipine.
ThymolThe risk or severity of adverse effects can be increased when Thymol is combined with Amlodipine.
TiboloneAmlodipine may increase the hypotensive activities of Tibolone.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Amlodipine.
TiclopidineThe metabolism of Amlodipine can be decreased when combined with Ticlopidine.
TicrynafenAmlodipine may increase the hypotensive activities of Ticrynafen.
TimololTimolol may increase the hypotensive activities of Amlodipine.
TioconazoleThe risk or severity of adverse effects can be increased when Tioconazole is combined with Amlodipine.
TizanidineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Tizanidine.
TocilizumabThe serum concentration of Amlodipine can be decreased when it is combined with Tocilizumab.
TolazolineAmlodipine may increase the hypotensive activities of Tolazoline.
TolnaftateThe risk or severity of adverse effects can be increased when Tolnaftate is combined with Amlodipine.
ToloxatoneToloxatone may increase the hypotensive activities of Amlodipine.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Amlodipine.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Amlodipine.
TorasemideTorasemide may increase the hypotensive activities of Amlodipine.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Amlodipine.
TrandolaprilAmlodipine may increase the hypotensive activities of Trandolapril.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Amlodipine.
TranylcypromineTranylcypromine may increase the hypotensive activities of Amlodipine.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Amlodipine.
TravoprostTravoprost may increase the hypotensive activities of Amlodipine.
TreprostinilTreprostinil may increase the hypotensive activities of Amlodipine.
TriamtereneThe risk or severity of adverse effects can be increased when Amlodipine is combined with Triamterene.
TrichlormethiazideAmlodipine may increase the hypotensive activities of Trichlormethiazide.
TrimazosinAmlodipine may increase the hypotensive activities of Trimazosin.
TrimethaphanAmlodipine may increase the hypotensive activities of Trimethaphan.
TrimetrexateThe risk or severity of adverse effects can be increased when Trimetrexate is combined with Amlodipine.
UdenafilUdenafil may increase the antihypertensive activities of Amlodipine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Amlodipine.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Amlodipine.
UnoprostoneAmlodipine may increase the hypotensive activities of Unoprostone.
ValsartanValsartan may increase the hypotensive activities of Amlodipine.
VardenafilVardenafil may increase the antihypertensive activities of Amlodipine.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Amlodipine.
VenlafaxineThe metabolism of Amlodipine can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Amlodipine.
VerapamilThe risk or severity of adverse effects can be increased when Amlodipine is combined with Verapamil.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Amlodipine.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Amlodipine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Amlodipine.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Amlodipine.
XylometazolineAmlodipine may increase the hypotensive activities of Xylometazoline.
YohimbineYohimbine may decrease the antihypertensive activities of Amlodipine.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Amlodipine.
ZiprasidoneThe metabolism of Amlodipine can be decreased when combined with Ziprasidone.
Food Interactions
  • Avoid natural licorice.
  • Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of amlodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of amlodipine and may cause toxicity. Avoid grapefruit products while on this medication.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1C
Uniprot ID:
Q13936
Molecular Weight:
248974.1 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Striessnig, J. (2004). Ca 2+ channel blockers. In Encyclopedic reference of molecular pharmacology (pp. 201-207). Berlin: Springer. [ISBN:9783540298328 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Gene Name:
CACNA2D1
Uniprot ID:
P54289
Molecular Weight:
124566.93 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Striessnig, J. (2004). Ca 2+ channel blockers. In Encyclopedic reference of molecular pharmacology (pp. 201-207). Berlin: Springer. [ISBN:9783540298328 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Gene Name:
CACNB2
Uniprot ID:
Q08289
Molecular Weight:
73579.925 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Striessnig, J. (2004). Ca 2+ channel blockers. In Encyclopedic reference of molecular pharmacology (pp. 201-207). Berlin: Springer. [ISBN:9783540298328 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity involved sa node cell action potential
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1D
Uniprot ID:
Q01668
Molecular Weight:
245138.75 Da
References
  1. Sinnegger-Brauns MJ, Huber IG, Koschak A, Wild C, Obermair GJ, Einzinger U, Hoda JC, Sartori SB, Striessnig J: Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol. 2009 Feb;75(2):407-14. doi: 10.1124/mol.108.049981. Epub 2008 Nov 24. [PubMed:19029287 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1S
Uniprot ID:
Q13698
Molecular Weight:
212348.1 Da
References
  1. Peterson BZ, Catterall WA: Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore. Mol Pharmacol. 2006 Aug;70(2):667-75. Epub 2006 May 4. [PubMed:16675661 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-...
Gene Name:
CACNA1B
Uniprot ID:
Q00975
Molecular Weight:
262493.84 Da
References
  1. Furukawa T, Nukada T, Suzuki K, Fujita Y, Mori Y, Nishimura M, Yamanaka M: Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine. Br J Pharmacol. 1997 Jul;121(6):1136-40. [PubMed:9249249 ]
  2. Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. [PubMed:10525060 ]
  3. Miyashita Y, Furukawa T, Kamegaya E, Yoshii M, Nukada T: A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine. Eur J Pharmacol. 2010 Apr 25;632(1-3):14-22. doi: 10.1016/j.ejphar.2010.01.006. Epub 2010 Jan 22. [PubMed:20097194 ]
  4. Murakami M, Nakagawasai O, Fujii S, Kameyama K, Murakami S, Hozumi S, Esashi A, Taniguchi R, Yanagisawa T, Tan-no K, Tadano T, Kitamura K, Kisara K: Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice. Eur J Pharmacol. 2001 May 11;419(2-3):175-81. [PubMed:11426839 ]
  5. Ogihara T, Kano T, Kakinuma C: Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling. Arzneimittelforschung. 2009;59(6):283-8. doi: 10.1055/s-0031-1296398. [PubMed:19634509 ]
  6. Qu YL, Sugiyama K, Ohnuki T, Hattori K, Watanabe K, Nagatomo T: Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain. Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):97-100. [PubMed:10374627 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated ion channel activity
Specific Function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).
Gene Name:
CACNA2D3
Uniprot ID:
Q8IZS8
Molecular Weight:
123010.22 Da
References
  1. Furukawa T, Nukada T, Suzuki K, Fujita Y, Mori Y, Nishimura M, Yamanaka M: Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine. Br J Pharmacol. 1997 Jul;121(6):1136-40. [PubMed:9249249 ]
  2. Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. [PubMed:10525060 ]
  3. Miyashita Y, Furukawa T, Kamegaya E, Yoshii M, Nukada T: A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine. Eur J Pharmacol. 2010 Apr 25;632(1-3):14-22. doi: 10.1016/j.ejphar.2010.01.006. Epub 2010 Jan 22. [PubMed:20097194 ]
  4. Murakami M, Nakagawasai O, Fujii S, Kameyama K, Murakami S, Hozumi S, Esashi A, Taniguchi R, Yanagisawa T, Tan-no K, Tadano T, Kitamura K, Kisara K: Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice. Eur J Pharmacol. 2001 May 11;419(2-3):175-81. [PubMed:11426839 ]
  5. Ogihara T, Kano T, Kakinuma C: Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling. Arzneimittelforschung. 2009;59(6):283-8. doi: 10.1055/s-0031-1296398. [PubMed:19634509 ]
  6. Qu YL, Sugiyama K, Ohnuki T, Hattori K, Watanabe K, Nagatomo T: Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain. Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):97-100. [PubMed:10374627 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
High voltage-gated calcium channel activity
Specific Function:
Not Available
Gene Name:
CACNB1
Uniprot ID:
Q6TME4
Molecular Weight:
23836.425 Da
References
  1. Furukawa T, Nukada T, Suzuki K, Fujita Y, Mori Y, Nishimura M, Yamanaka M: Voltage and pH dependent block of cloned N-type Ca2+ channels by amlodipine. Br J Pharmacol. 1997 Jul;121(6):1136-40. [PubMed:9249249 ]
  2. Furukawa T, Yamakawa T, Midera T, Sagawa T, Mori Y, Nukada T: Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1999 Nov;291(2):464-73. [PubMed:10525060 ]
  3. Miyashita Y, Furukawa T, Kamegaya E, Yoshii M, Nukada T: A region of N-type Ca(2+) channel critical for blockade by the dihydropyridine amlodipine. Eur J Pharmacol. 2010 Apr 25;632(1-3):14-22. doi: 10.1016/j.ejphar.2010.01.006. Epub 2010 Jan 22. [PubMed:20097194 ]
  4. Murakami M, Nakagawasai O, Fujii S, Kameyama K, Murakami S, Hozumi S, Esashi A, Taniguchi R, Yanagisawa T, Tan-no K, Tadano T, Kitamura K, Kisara K: Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice. Eur J Pharmacol. 2001 May 11;419(2-3):175-81. [PubMed:11426839 ]
  5. Ogihara T, Kano T, Kakinuma C: Evaluation of the inhibitory effect of dihydropyridines on N-type calcium channel by virtual three-dimensional pharmacophore modeling. Arzneimittelforschung. 2009;59(6):283-8. doi: 10.1055/s-0031-1296398. [PubMed:19634509 ]
  6. Qu YL, Sugiyama K, Ohnuki T, Hattori K, Watanabe K, Nagatomo T: Comparison of binding affinities of omega-conotoxin and amlodipine to N-type Ca2+ channels in rat brain. Zhongguo Yao Li Xue Bao. 1998 Mar;19(2):97-100. [PubMed:10374627 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
Gene Name:
CA1
Uniprot ID:
P00915
Molecular Weight:
28870.0 Da
References
  1. Puscas I, Gilau L, Coltau M, Pasca R, Domuta G, Baican M, Hecht A: Hypotensive effect of calcium channel blockers is parallel with carbonic anhydrase I inhibition. Clin Pharmacol Ther. 2000 Oct;68(4):443-9. [PubMed:11061585 ]
  2. Puscas L, Gilau L, Coltau M, Pasca R, Domuta G, Baican M, Hecht A: Calcium channel blockers reduce blood pressure in part by inhibiting vascular smooth muscle carbonic anhydrase I. Cardiovasc Drugs Ther. 2000 Oct;14(5):523-8. [PubMed:11101200 ]
  3. Puscas I, Coltau M, Baican M, Pasca R, Domuta G, Hecht A: Vasoconstrictive drugs increase carbonic anhydrase I in vascular smooth muscle while vasodilating drugs reduce the activity of this isozyme by a direct mechanism of action. Drugs Exp Clin Res. 2001;27(2):53-60. [PubMed:11392054 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sphingomyelin phosphodiesterase activity
Specific Function:
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
Gene Name:
SMPD1
Uniprot ID:
P17405
Molecular Weight:
69751.3 Da
References
  1. Kornhuber J, Muehlbacher M, Trapp S, Pechmann S, Friedl A, Reichel M, Muhle C, Terfloth L, Groemer TW, Spitzer GM, Liedl KR, Gulbins E, Tripal P: Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8):e23852. doi: 10.1371/journal.pone.0023852. Epub 2011 Aug 31. [PubMed:21909365 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. [PubMed:10805063 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. [PubMed:10805063 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. [PubMed:10805063 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Katoh M, Nakajima M, Shimada N, Yamazaki H, Yokoi T: Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. [PubMed:10805063 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Katoh M, Nakajima M, Yamazaki H, Yokoi T: Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. Pharm Res. 2000 Oct;17(10):1189-97. [PubMed:11145223 ]
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Drug created on June 13, 2005 07:24 / Updated on October 01, 2016 03:35