You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Accession NumberDB00646  (APRD01146)
TypeSmall Molecule
GroupsApproved, Vet Approved

Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections.

External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dom-nystatin 100.000 Iu/ml Oral Suspensionsuspension100 unitoralDominion Pharmacal1998-08-05Not applicableCanada
Ftp-nystatindrops100000 unitoralFtp Pharmacal Inc.1998-10-092004-08-03Canada
Jamp-nystatin Oral Suspension USPsuspension100000 unitoralJamp Pharma Corporation2015-01-09Not applicableCanada
Mestatincream25000 unitvaginalMedic Laboratory LtÉe1980-12-311996-09-09Canada
Mycostatin Oral Suspension 100000iuliquid100000 unitoralSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.1972-12-312003-07-28Canada
Mycostatin Oral Tab 500000iutablet500000 unitoralSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.1955-12-312002-07-30Canada
Mycostatin Vaginal Crm 25000unitcream25000 unitvaginalSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.1973-12-312005-08-01Canada
Nadostine Sus 100000iu/mlsuspension100000 unitoralLab Nadeau LtÉe, Division Of Technilab Inc.1974-12-312004-08-03Canada
Nadostine Tab 100000unittablet100000 unitvaginalLab Nadeau LtÉe, Division Of Technilab Inc.1973-12-312004-08-03Canada
Nadostine Tab 500000unittablet500000 unitoralLab Nadeau LtÉe, Division Of Technilab Inc.1973-12-311999-09-28Canada
Nilstat 25000units/gcream25000 unitvaginalTechnilab Pharma Inc.1974-12-312004-08-03Canada
Nilstat Oral Dps 100000iu/mldrops100000 unitoralLederle Cyanamid Canada Inc.1970-12-311997-01-29Canada
Nilstat Orl Tab 500000unittablet500000 unitoralLederle Cyanamid Canada Inc.1970-12-311997-01-29Canada
Nilstat Sucrose-freesuspension100000 unitoralTechnilab Pharma Inc.1997-03-122004-08-03Canada
Nilstat Vag Crm 100000unit/gmcream100000 unitvaginalLederle Cyanamid Canada Inc.1973-12-311997-08-14Canada
Nilstat Vag Tab 100000unittablet100000 unitvaginalLederle Cyanamid Canada Inc.1970-12-311997-08-14Canada
Nyaderm Oral Sus 100000unit/ml USPsuspension100000 unitoralTaro Pharmaceuticals Inc1989-12-31Not applicableCanada
Nyaderm Vag Crm 25000unit/gmcream25000 unitvaginalTaro Pharmaceuticals Inc1979-12-31Not applicableCanada
PHL-nystatin Suspension 100000 Unit/mlsuspension100000 unitoralPharmel IncNot applicableNot applicableCanada
PMS-nystatin Suspension 100000 Unit/mlsuspension100000 unitoralPharmascience Inc1989-12-31Not applicableCanada
Ratio-nystatintablet100000 unitvaginalRatiopharm Inc Division Of Teva Canada Limited1998-07-092008-08-01Canada
Ratio-nystatindrops100000 unitoralTeva Canada Limited1996-09-12Not applicableCanada
Ratio-nystatincream100000 unitvaginalTeva Canada Limited1998-10-14Not applicableCanada
Ratio-nystatintablet500000 unitoralRatiopharm Inc Division Of Teva Canada Limited1997-01-202013-01-21Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Nyamycpowder100000 [USP'U]/gcutaneousUpsher Smith Laboratories Inc.2005-05-03Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralSTAT Rx USA LLC2005-06-28Not applicableUs
Nystatinpowder100000 [USP'U]/gtopicalPhysicians Total Care, Inc.2005-01-27Not applicableUs
Nystatincream100000 [USP'U]/gtopicalDispensing Solutions, Inc.2006-05-31Not applicableUs
Nystatincream100000 [USP'U]/gtopicalPerrigo New York Inc2006-09-21Not applicableUs
Nystatintablet, film coated500000 [USP'U]/1oralTeva Pharmaceuticals USA Inc1990-09-30Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralHi Tech Pharmacal Co., Inc.2012-01-27Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralCardinal Health2010-05-10Not applicableUs
Nystatincream100000 mg/gtopicalRebel Distributors Corp1993-01-29Not applicableUs
Nystatincream100000 [USP'U]/gtopicalPreferred Pharmaceuticals, Inc.2014-01-13Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralPharmaceutical Associates, Inc.2016-02-01Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalActavis Mid Atlantic LLC2002-09-03Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralA S Medication Solutions Llc1988-02-29Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralbryant ranch prepack1995-04-15Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalRebel Distributors Corp1982-09-23Not applicableUs
Nystatinpowder100000 U/gtopicalMajor Pharmaceuticals2015-02-15Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalPhysicians Total Care, Inc.2007-04-11Not applicableUs
Nystatintablet, film coated500000 [USP'U]/1oralCarilion Materials Management1990-09-30Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalPerrigo New York Inc2006-09-15Not applicableUs
Nystatincream100000 [USP'U]/gtopicalCentral Texas Community Health Centers1979-02-01Not applicableUs
Nystatincream100000 [USP'U]/gtopicalActavis Mid Atlantic LLC2010-07-21Not applicableUs
Nystatintablet, film coated500000 [USP'U]/1oralMutual Pharmaceutical Company, Inc.1988-12-22Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalProficient Rx LP2002-09-03Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralRebel Distributors Corp1995-04-15Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralPhysicians Total Care, Inc.1994-03-28Not applicableUs
Nystatinsuspension500000 [USP'U]/5mLoralPrecision Dose, Inc.2005-12-15Not applicableUs
Nystatinpowder100000 U/gtopicalGavis Pharmaceuticals, LLC.2014-09-26Not applicableUs
Nystatinpowder100000 [USP'U]/gtopicalH.J. Harkins Company, Inc.2009-09-15Not applicableUs
Nystatincream100000 [USP'U]/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1979-02-01Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalAidarex Pharmaceuticals LLC2002-09-03Not applicableUs
Nystatincream100000 [USP'U]/gtopicalProficient Rx LP2010-07-21Not applicableUs
Nystatinpowder100000 [USP'U]/gtopicalX Gen Pharmaceuticals, Inc.2004-08-30Not applicableUs
Nystatincream100000 [USP'U]/gtopicalG&W Laboratories, Inc.2015-04-01Not applicableUs
Nystatincream100000 [USP'U]/gtopicalPhysicians Total Care, Inc.1995-01-31Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralVista Pharm, Inc2010-05-10Not applicableUs
Nystatinpowder100000 [USP'U]/gtopicalVensun Pharmaceuticals, Inc.2014-09-01Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalPreferred Pharmaceuticals, Inc.2014-02-10Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1984-06-07Not applicableUs
Nystatincream100000 [USP'U]/gtopicalREMEDYREPACK INC.2013-09-19Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralMorton Grove Pharmaceuticals, Inc.1995-04-15Not applicableUs
Nystatintablet, film coated500000 [USP'U]/1oralAidarex Pharmaceuticals LLC1988-12-22Not applicableUs
Nystatincream100000 [USP'U]/gtopicalQualitest Pharmaceuticals2006-05-31Not applicableUs
Nystatincream100000 [USP'U]/gtopicalA S Medication Solutions Llc2006-05-31Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralVista Pharm Inc.2012-05-01Not applicableUs
Nystatintablet, film coated500000 [USP'U]/1oralAv Kare, Inc.2014-01-20Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalE. Fougera & CO., A division of Fougera Pharmaceuticals Inc.1982-09-23Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralTaro Pharmaceuticals U.S.A., Inc.1988-02-29Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralCardinal Health2009-06-01Not applicableUs
Nystatincream100000 [USP'U]/gtopicalArbor Pharmaceuticals Inc.1993-01-28Not applicableUs
Nystatincream100000 [USP'U]/gtopicalPreferred Pharmaceuticals, Inc.2014-11-13Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralQualitest Pharmaceuticals2005-06-28Not applicableUs
Nystatincream100000 [USP'U]/gtopicalA S Medication Solutions Llc2006-05-31Not applicableUs
Nystatinsuspension100000 [USP'U]/15mLoralLehigh Valley Technologies, Inc.2014-04-01Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralRebel Distributors Corp2012-01-27Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralRebel Distributors Corp2005-06-28Not applicableUs
Nystatinsuspension500000 [USP'U]/5mLoralCardinal Health2005-12-15Not applicableUs
Nystatinpowder100000 [USP'U]/gtopicalMayne Pharma Inc.2004-07-15Not applicableUs
Nystatincream100000 [USP'U]/gtopicalLake Erie Medical DBA Quality Care Products LLC2006-05-31Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralPharmaceutical Associates, Inc.2009-06-01Not applicableUs
Nystatincream100000 [USP'U]/gtopicalTaro Pharmaceuticals U.S.A., Inc.1993-01-28Not applicableUs
Nystatintablet, film coated500000 [USP'U]/1oralCardinal Health1984-01-16Not applicableUs
Nystatintablet, coated500000 [USP'U]/1oralHeritage Pharmaceuticals Inc2011-10-31Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralPreferred Pharmaceuticals, Inc2005-06-28Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralPharmaceutical Associates, Inc.2016-02-01Not applicableUs
Nystatinointment100000 [USP'U]/gtopicalA S Medication Solutions Llc2006-09-15Not applicableUs
Nystatinsuspension100000 [USP'U]/mLoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation1995-04-15Not applicableUs
Nystatinpowder100000 [USP'U]/gtopicalRebel Distributors Corp2009-09-15Not applicableUs
Nystoppowder100000 [USP'U]/gtopicalPaddock Laboratories, LLC1996-08-16Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Candistatin Topical Powder - 100000 Unit/gpowder100000 unittopicalBristol Myers Squibb Canada1996-12-312008-04-25Canada
Mycostatin Crm 100000unit/gmcream100000 unittopicalSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.1970-12-312006-09-06Canada
Mycostatin Ont 100000iu/gmointment100000 unittopicalSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.1955-12-312002-07-30Canada
Mycostatin Topical Pwr 100,000units/gmpowder100000 unittopicalConvatec, Division Of Bristol Myers Squibb Canada Co.1994-12-312008-11-12Canada
Nadostine Crm 100000iu/gmcream100000 unittopicalLab Nadeau LtÉe, Division Of Technilab Inc.1974-12-312004-08-03Canada
Nadostine Ont 100000iu/gmointment100000 unittopicalLab Nadeau LtÉe, Division Of Technilab Inc.1974-12-312004-08-03Canada
Nilstat Top Crm 100000unit/gmcream100000 unittopicalLederle Cyanamid Canada Inc.1979-12-311997-01-29Canada
Nilstat Top Ont 100000unit/gmointment100000 unittopicalLederle Cyanamid Canada Inc.1979-12-311997-01-29Canada
Nyaderm Crm 100000unit/gmcream100000 unittopicalTaro Pharmaceuticals Inc1979-12-31Not applicableCanada
Nyaderm Ont 100000unit/gmointment100000 unittopicalTaro Pharmaceuticals Inc1979-12-31Not applicableCanada
Ratio-nystatinointment100000 unittopicalTeva Canada Limited1996-11-28Not applicableCanada
Ratio-nystatincream100000 unittopicalTeva Canada Limited1996-09-12Not applicableCanada
Unapproved/Other Products Not Available
International Brands
AfunginalEuro Generics
CandacideBe-Tabs Pharmaceuticals
CandistatAmbalal Sarabhai Enterprises
CanstatAspen Pharmacare
Diaper NZCheminter
Fungicidin LecivaZentiva
KenalonTa Fong
MycostatinBristol Myers Squibb
NystanBristol Myers Squibb
Brand mixtures
First Dukes Mouthwash CompoundingCutis Pharma, Inc.
First Marys Mouthwash CompoundingCutis Pharma, Inc.
FlagystatinAventis Pharma Inc
Flagystatin CreamSanofi Aventis Canada Inc
Flagystatin Vaginal OvuleSanofi Aventis Canada Inc
Kenacomb CreamWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb Mild CreamWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb Mild OintmentWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb OintmentWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.
Kenacomb OntSquibb Canada Inc., Division Of Bristol Myers Squibb Canada Inc.
Lidecomb CreamMedicis Canada Ltd.
Mecomb Crm 0.1%Medic Laboratory LtÉe
NyataCrown Laboratories
Nystatin and TriamcinoloneSTAT RX LLC USA
Nystatin and Triamcinolone AcetonideE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.
Ratio-triacombTeva Canada Limited
Theraderm CreamBimeda Mtc Animal Health Inc
Viaderm Kc CrmTaro Pharmaceuticals Inc
Viaderm Kc OntTaro Pharmaceuticals Inc
Nystatin dihydrate
ThumbNot applicableDBSALT001007
CAS number1400-61-9
WeightAverage: 926.0949
Monoisotopic: 925.503499979
Chemical FormulaC47H75NO17
(21E,23E,25E,27E,31E,33E)-20-{[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxo-1-oxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid
C[[email protected]]1OC(OC2CC(O)C(C(O)CC(=O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)OC(C)C(C)C(O)C(C)\C=C\C=C\CC\C=C\C=C\C=C\C=C\2)C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O
DescriptionThis compound belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
KingdomOrganic compounds
Super ClassPhenylpropanoids and polyketides
ClassMacrolides and analogues
Sub ClassNot Available
Direct ParentMacrolides and analogues
Alternative Parents
  • Macrolide
  • Glucosamine
  • Amino sugar
  • O-glycosyl compound
  • Glycosyl compound
  • Amino saccharide
  • Beta-hydroxy acid
  • Oxane
  • Monosaccharide
  • Hydroxy acid
  • Dicarboxylic acid or derivatives
  • Saccharide
  • Cyclic ketone
  • Secondary alcohol
  • Polyol
  • Lactone
  • Ketone
  • Carboxylic acid ester
  • 1,2-diol
  • 1,2-aminoalcohol
  • Oxacycle
  • Organoheterocyclic compound
  • Carboxylic acid
  • Carboxylic acid derivative
  • Acetal
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
IndicationFor treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species
PharmacodynamicsNystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (C. tropicalis, C. guilliermondi, C. krusei, and C. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
Mechanism of actionNystatin exerts its antifungal activity by binding to ergosterol found in fungal cell membranes. Binding to ergosterol causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death.
Related Articles
AbsorptionNystatin is not absorbed from intact skin or mucous membrane.
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Fungi
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Predicted ADMET features
Human Intestinal Absorption-0.8641
Blood Brain Barrier-0.9581
Caco-2 permeable-0.741
P-glycoprotein substrateSubstrate0.5182
P-glycoprotein inhibitor INon-inhibitor0.814
P-glycoprotein inhibitor IINon-inhibitor0.6721
Renal organic cation transporterNon-inhibitor0.96
CYP450 2C9 substrateNon-substrate0.8313
CYP450 2D6 substrateNon-substrate0.867
CYP450 3A4 substrateNon-substrate0.5273
CYP450 1A2 substrateNon-inhibitor0.916
CYP450 2C9 inhibitorNon-inhibitor0.9374
CYP450 2D6 inhibitorNon-inhibitor0.9354
CYP450 2C19 inhibitorNon-inhibitor0.9243
CYP450 3A4 inhibitorNon-inhibitor0.931
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.987
Ames testNon AMES toxic0.8992
BiodegradationNot ready biodegradable0.8601
Rat acute toxicity2.1245 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9462
hERG inhibition (predictor II)Non-inhibitor0.8971
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
  • Bayer pharmaceuticals corp
  • Bristol myers squibb co
  • Alpharma us pharmaceuticals division
  • Lederle laboratories div american cyanamid co
  • Actavis mid atlantic llc
  • Altana inc
  • Perrigo new york inc
  • Taro pharmaceuticals usa inc
  • Teva pharmaceuticals usa inc
  • Vintage pharmaceuticals llc
  • Westwood squibb pharmaceuticals inc
  • Bristol myers squibb
  • Barlan pharmacal co inc
  • Dava pharmaceuticals inc
  • Paddock laboratories inc
  • Coastal pharmaceuticals inc
  • Kv pharmaceutical co
  • Par pharmaceutical inc
  • Upsher smith laboratories inc
  • X gen pharmaceuticals inc
  • Warner chilcott co llc
  • Apothecon inc div bristol myers squibb
  • Glenmark generics inc usa
  • Bausch and lomb pharmaceuticals inc
  • E fougera div altana inc
  • Morton grove pharmaceuticals inc
  • Pharmaderm div altana inc
  • Pharmafair inc
  • Roxane laboratories inc
  • Vintage pharmaceuticals inc
  • Vistapharm inc
  • Wockhardt eu operations (swiss) ag
  • Savage laboratories inc div altana inc
  • Mutual pharmaceutical co inc
  • Quantum pharmics ltd
  • Sandoz inc
  • Usl pharma inc
  • Watson laboratories inc
  • Holland rantos co inc
  • Odyssey pharmaceuticals inc
Dosage forms
Suspensionoral100 unit
Liquidoral100000 unit
Powdertopical100000 unit
Tabletvaginal100000 unit
Tabletoral500000 unit
Suspensionoral100000 unit
Creamvaginal25000 unit
Powdercutaneous100000 [USP'U]/g
Creamtopical100000 [USP'U]/g
Creamtopical100000 mg/g
Ointmenttopical100000 [USP'U]/g
Powdertopical100000 U/g
Suspensionoral100000 [USP'U]/15mL
Suspensionoral100000 [USP'U]/mL
Suspensionoral500000 [USP'U]/5mL
Tablet, coatedoral500000 [USP'U]/1
Tablet, film coatedoral500000 [USP'U]/1
Powdertopical100000 [USP'U]/g
Creamtopical100000 unit
Creamvaginal100000 unit
Dropsoral100000 unit
Ointmenttopical100000 unit
Unit descriptionCostUnit
Nystatin 10 billion unit powder3014.1USD each
Nystatin 5 billion unit powder2096.1USD each
Nystatin 2 billion unit powder1116.9USD each
Nystatin 1 billion unit powder452.08USD each
Nystat-rx 5 billion unit powder447.0USD each
Nystatin 500 million unit powder130.75USD each
Pedi-Dri 100000 unit/gm Powder 56.7 gm Bottle105.87USD bottle
Nystatin 150mu Bottle94.5USD bottle
Nystatin 150 million unit powder42.25USD each
Nystatin 150000000 unit powder42.0USD each
Nystatin Nystatin Powder 50 Million unit Bottle39.99USD bottle
Mycostatin 100000 unit/gm Powder 15 gm Bottle36.99USD bottle
Nystop 100000 unit/gm Powder 15 gm Bottle29.99USD bottle
Nystatin 50 million unit powder19.75USD each
Nystatin 100000 unit/gm Ointment 15 gm Tube12.99USD tube
Nystatin 100000 unit/gm Cream 15 gm Tube6.5USD tube
Nystatin 100000 unit tablet5.29USD tablet
Nystatin vaginal tablet5.0USD tablet
Pedi-dri topical powder1.82USD g
Nystop 100000 unit/gm powder1.6USD g
Nystatin 500000 unit tablet0.71USD tablet
Nystatin 500000 unit oral tablet0.68USD tablet
Mycostatin 500000 unit orl tablet0.48USD tablet
Nystatin 100000 unit/ml Suspension0.25USD ml
Ratio-Nystatin 500000 unit Tablet0.25USD tablet
Nystatin 100000 unit/gm cream0.1USD g
Pms-Nystatin 100000 unit/ml Suspension0.05USD ml
Ratio-Nystatin 100000 unit/ml Suspension0.05USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Experimental Properties
melting point160 °CNot Available
water solubility360 mg/L (at 24 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP0.5Not Available
Predicted Properties
Water Solubility0.066 mg/mLALOGPS
pKa (Strongest Acidic)3.62ChemAxon
pKa (Strongest Basic)9.11ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count17ChemAxon
Hydrogen Donor Count12ChemAxon
Polar Surface Area327.45 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity245.18 m3·mol-1ChemAxon
Polarizability102.11 Å3ChemAxon
Number of Rings2ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Mass Spec (NIST)Not Available
SpectraNot Available
Synthesis ReferenceNot Available
General References
  1. Akaike N, Harata N: Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol. 1994;44(5):433-73. [PubMed:7534361 ]
External Links
ATC CodesG01AA01A07AA02D01AA01G01AA51
AHFS Codes
  • 08:14.28
  • 84:04.08.28
PDB EntriesNot Available
FDA labelDownload (776 KB)
MSDSDownload (72.5 KB)
Drug InteractionsNot Available
Food InteractionsNot Available


1. Ergosterol
Small molecule
Candida albicans
Pharmacological action
  1. Silva L, Coutinho A, Fedorov A, Prieto M: Competitive binding of cholesterol and ergosterol to the polyene antibiotic nystatin. A fluorescence study. Biophys J. 2006 May 15;90(10):3625-31. Epub 2006 Feb 24. [PubMed:16500971 ]
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23