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Identification
NameTizanidine
Accession NumberDB00697  (APRD00128)
TypeSmall Molecule
GroupsApproved
Description

Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.

Structure
Thumb
Synonyms
SynonymLanguageCode
5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazoleNot AvailableNot Available
TizanidinGermanINN
TizanidinaSpanishINN
TizanidineFrenchINN
TizanidinumLatinINN
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Tizanidine Hydrochloridecapsule, gelatin coated2 mgoralWatson Laboratories, Inc.2012-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated4 mgoralWatson Laboratories, Inc.2012-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated6 mgoralWatson Laboratories, Inc.2012-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflextablet4 mgoralAcorda Therapeutics, Inc.1997-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule2 mgoralAcorda Therapeutics, Inc.2005-04-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule4 mgoralAcorda Therapeutics, Inc.2005-04-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule6 mgoralAcorda Therapeutics, Inc.2005-04-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule6 mgoralSTAT Rx USA LLC2002-08-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule4 mgoralSTAT Rx USA LLC2002-08-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule, gelatin coated4 mgoralRebel Distributors Corp2002-08-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule2 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule4 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflexcapsule6 mgoralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Zanaflextablet4 mgoralPd Rx Pharmaceuticals, Inc.1997-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated2 mgoralClinical Solutions Wholesale2012-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated6 mgoralbryant ranch prepack2012-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Tizanidine Hydrochloridetablet2 mgoralEon Labs, Inc.2002-11-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralEon Labs, Inc.2002-06-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralMylan Pharmaceuticals Inc.2003-05-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralMylan Pharmaceuticals Inc.2003-05-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule2 mgoralMylan Pharmaceuticals Inc.2013-03-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule4 mgoralMylan Pharmaceuticals Inc.2013-03-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule6 mgoralMylan Pharmaceuticals Inc.2013-03-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralMajor Pharmaceuticals2010-07-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4.576 mgoralMajor Pharmaceuticals2014-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralBlenheim Pharmacal, Inc.2014-01-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralBlenheim Pharmacal, Inc.2014-12-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralSTAT Rx USA LLC2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralSTAT Rx USA LLC2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet2 mgoralRebel Distributors2007-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralRebel Distributors2007-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralUnichem Pharmaceuticals (USA), Inc.2013-04-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralUnichem Pharmaceuticals (USA), Inc.2013-04-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralAidarex Pharmaceuticals LLC2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralAidarex Pharmaceuticals LLC2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet2 mgoralLake Erie Medical DBA Quality Care Products LLC2007-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated2 mgoralAv Kare, Inc.2014-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated4 mgoralAv Kare, Inc.2014-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated6 mgoralAv Kare, Inc.2014-06-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet2 mgoralSTAT Rx USA LLC2002-11-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralSTAT Rx USA LLC2002-06-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralPd Rx Pharmaceuticals, Inc.2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralAphena Pharma Solutions Tennessee, Llc2003-05-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralAphena Pharma Solutions Tennessee, Llc2003-05-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralMedsource Pharmaceuticals2008-12-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralMedsource Pharmaceuticals2009-01-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralREMEDYREPACK INC.2014-11-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralLake Erie Medical DBA Quality Care Products LLC2010-11-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet2 mgoralLake Erie Medical DBA Quality Care Products LLC2011-04-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralUnit Dose Services2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralUnit Dose Services2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralUDL Laboratories, Inc.2011-01-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralREMEDYREPACK INC.2014-07-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralREMEDYREPACK INC.2013-02-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralREMEDYREPACK INC.2013-05-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralREMEDYREPACK INC.2013-05-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralH.J. Harkins Company, Inc.2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralH.J. Harkins Company, Inc.2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralPhysicians Total Care, Inc.2004-01-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralPhysicians Total Care, Inc.2004-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralDr.Reddy's Laboratories Limited2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralDr.Reddy's Laboratories Limited2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralCardinal Health2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralCardinal Health2011-01-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralCardinal Health2013-03-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralPd Rx Pharmaceuticals, Inc.2002-06-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet2 mgoralPd Rx Pharmaceuticals, Inc.2002-11-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralSun Pharmaceutical Industries, Inc.2003-12-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralSun Pharmaceutical Industries, Inc.2003-12-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralClinical Solutions Wholesale2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralClinical Solutions Wholesale2002-06-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralNew Horizon Rx Group, LLC2013-08-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralGolden State Medical Supply, Inc.2004-01-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralGolden State Medical Supply, Inc.2004-01-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralApotex Corp.2004-01-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralApotex Corp.2004-01-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated2 mgoralApotex Corp.2012-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated4 mgoralApotex Corp.2012-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridecapsule, gelatin coated6 mgoralApotex Corp.2012-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralTIZANIDINE HYDROCHLORIDE2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralProficient Rx LP2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralProficient Rx LP2004-01-16Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralbryant ranch prepack2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralbryant ranch prepack2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralAltura Pharmaceuticals, Inc.2010-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralCore Pharma, Llc2007-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralCore Pharma, Llc2007-02-06Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralDispensing Solutions, Inc.2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralAmerican Health Packaging2013-07-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralAmerican Health Packaging2013-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet2 mgoralAmerican Health Packaging2014-06-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet2 mgoralKeltman Pharmaceuticals Inc.2005-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidine Hydrochloridetablet4 mgoralKeltman Pharmaceuticals Inc.2005-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralPreferred Pharmaceuticals, Inc2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralPreferred Pharmaceuticals, Inc2002-07-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet2 mgoralPreferred Pharmaceuticals, Inc.2014-03-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralPreferred Pharmaceuticals, Inc.2014-03-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Tizanidinetablet4 mgoralMc Kesson Contract Packaging2012-02-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
CimbrarEuroetika
MusantActavis
MyoresMeprofarm
NavizanCaber
RelaxkovBlaskov
SirdalidNovartis
SirdaludNovartis
Sirdalud MRNovartis
SizolanDr. Reddy's
SpaslaxPanion & BF
TelzanineNisshin Seiyaku
TernelinNovartis
TizadinACL
TizaflexActavis
TizaludOpsonin
TizanSun
ZanpeakTatsumi Kagaku
ZitanidNovell
Brand mixtures
Brand NameIngredients
Acent-TZTizanidine and Aceclofenac
Amiox-KTizanidine and Ketorolac
Amiox-PTizanidine and Paracetamol
Carnil-MRTizanidine and Nimesulide
CitanzTizanidine and Nimesulide
FlectadolTizanidine and Ibuprofen
Meftal-MRTizanidine and Mefenamic Acid
Nimulid-MRTizanidine and Nimesulide
Nimvar-MRTizanidine and Nimesulide
Nizi Tizanidine and Nimesulide
Novolid-MRTizanidine and Nimesulide
Orthobid-MRTizanidine and Nimesulide
Sixer-TIZTizanidine and Diclofenac
Sumo-MRTizanidine and Nimesulide
TizafenTizanidine and Ibuprofen
TizanacTizanidine and Diclofenac
TizuTizanidine and Nimesulide
ZalideTizanidine and Nimesulide
Salts
Name/CASStructureProperties
Tizanidine Hydrochloride
Thumb
  • InChI Key: ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
  • Monoisotopic Mass: 288.995571417
  • Average Mass: 290.172
DBSALT000550
Categories
CAS number51322-75-9
WeightAverage: 253.711
Monoisotopic: 253.018893678
Chemical FormulaC9H8ClN5S
InChI KeyXFYDIVBRZNQMJC-UHFFFAOYSA-N
InChI
InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13)
IUPAC Name
5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
SMILES
ClC1=C(NC2=NCCN2)C2=NSN=C2C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzothiadiazoles. These are heterocyclic aromatic compounds containing a benzene ring fused to a thiadiazole ring. Thiadiazole is a five-membered aromatic heterocycle made up of one sulfur atom and two nitrogen atoms.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiadiazoles
Sub ClassNot Available
Direct ParentBenzothiadiazoles
Alternative Parents
Substituents
  • 2,1,3-benzothiadiazole
  • Benzenoid
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Thiadiazole
  • 2-imidazoline
  • Azole
  • Guanidine
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Carboximidamide
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the management of increased muscle tone associated with spasticity
PharmacodynamicsTizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.
Mechanism of actionTizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites.
AbsorptionNot Available
Volume of distribution
  • 2.4 L/kg
Protein binding30%
Metabolism
SubstrateEnzymesProduct
Tizanidine
5-chloro-4-(guanidino)-2,1,3-benzothiadiazoleDetails
Tizanidine
5-chloro-4-(2-imidazolin-4-on-2-ylamino)-2,1,3-benzothiadiazoleDetails
Route of eliminationApproximately 95% of an administered dose is metabolized.
Half life2.5 hours
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.8592
Caco-2 permeable+0.5323
P-glycoprotein substrateSubstrate0.6545
P-glycoprotein inhibitor INon-inhibitor0.8365
P-glycoprotein inhibitor IINon-inhibitor0.7953
Renal organic cation transporterInhibitor0.6577
CYP450 2C9 substrateNon-substrate0.7953
CYP450 2D6 substrateNon-substrate0.8018
CYP450 3A4 substrateNon-substrate0.5795
CYP450 1A2 substrateNon-inhibitor0.5248
CYP450 2C9 substrateNon-inhibitor0.7117
CYP450 2D6 substrateNon-inhibitor0.7867
CYP450 2C19 substrateNon-inhibitor0.6353
CYP450 3A4 substrateNon-inhibitor0.781
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5
Ames testNon AMES toxic0.6538
CarcinogenicityNon-carcinogens0.8915
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6573 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.6935
hERG inhibition (predictor II)Non-inhibitor0.8907
Pharmacoeconomics
Manufacturers
  • Acorda therapeutics inc
  • Actavis elizabeth llc
  • Actavis totowa llc
  • Alphapharm party ltd
  • Apotex inc
  • Barr laboratories inc
  • Caraco pharmaceutical laboratories ltd
  • Corepharma llc
  • Dr reddys laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Mylan pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral2 mg
Capsuleoral4 mg
Capsuleoral6 mg
Capsule, gelatin coatedoral2 mg
Capsule, gelatin coatedoral4 mg
Capsule, gelatin coatedoral6 mg
Tabletoral2 mg
Tabletoral4 mg
Tabletoral4.576 mg
Prices
Unit descriptionCostUnit
Zanaflex 6 mg capsule4.79USD capsule
Zanaflex 4 mg capsule3.2USD capsule
Zanaflex 2 mg capsule2.52USD capsule
Zanaflex 4 mg tablet2.29USD tablet
Tizanidine hcl 4 mg tablet1.49USD tablet
Zanaflex 2 mg tablet1.42USD tablet
Tizanidine hcl 2 mg tablet1.25USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
United States64555572001-11-282021-11-28
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP1.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.133 mg/mLALOGPS
logP1.6ALOGPS
logP2.02ChemAxon
logS-3.3ALOGPS
pKa (Strongest Basic)7.49ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area62.2 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity64.77 m3·mol-1ChemAxon
Polarizability23.97 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraMS
References
Synthesis Reference

Pavel Hradil, Lubomir Kvapil, Martin Grepl, Jan Novotny, “METHOD FOR THE PREPARATION OF TIZANIDINE HYDROCHLORIDE.” U.S. Patent US20110263863, issued October 27, 2011.

US20110263863
General ReferenceNot Available
External Links
ATC CodesM03BX02
AHFS Codes
  • 12:20.00
PDB EntriesNot Available
FDA labelDownload (145 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
BenazeprilMay enhance the hypotensive effect of ACE Inhibitors.
BretyliumMay enhance the bradycardic effect of Bradycardia-Causing Agents. Bretylium may also enhance atrioventricular (AV) blockade in patients receiving AV blocking agents.
BuprenorphineCNS Depressants may enhance the CNS depressant effect of Buprenorphine.
ButabarbitalMay enhance the hypotensive effect of Hypotensive Agents.
ButethalMay enhance the hypotensive effect of Hypotensive Agents.
CaptoprilMay enhance the hypotensive effect of ACE Inhibitors.
CilazaprilMay enhance the hypotensive effect of ACE Inhibitors.
DeferasiroxMay increase the serum concentration of CYP1A2 Substrates.
DesogestrelContraceptives (Estrogens) may increase the serum concentration of TiZANidine.
DoxylamineMay enhance the CNS depressant effect of CNS Depressants.
DronabinolMay enhance the CNS depressant effect of CNS Depressants.
DroperidolMay enhance the CNS depressant effect of CNS Depressants.
DuloxetineHypotensive Agents may enhance the orthostatic hypotensive effect of DULoxetine.
EnalaprilMay enhance the hypotensive effect of ACE Inhibitors.
Ethinyl EstradiolContraceptives (Estrogens) may increase the serum concentration of TiZANidine.
EthynodiolContraceptives (Estrogens) may increase the serum concentration of TiZANidine.
FluvoxamineFluvoxaMINE may decrease the metabolism of TiZANidine.
FosinoprilMay enhance the hypotensive effect of ACE Inhibitors.
HeptabarbitalMay enhance the hypotensive effect of Hypotensive Agents.
HexobarbitalMay enhance the hypotensive effect of Hypotensive Agents.
HydrocodoneCNS Depressants may enhance the CNS depressant effect of Hydrocodone.
HydroxyzineMay enhance the CNS depressant effect of CNS Depressants.
LacosamideBradycardia-Causing Agents may enhance the AV-blocking effect of Lacosamide.
LisinoprilTiZANidine may enhance the hypotensive effect of Lisinopril.
Magnesium SulfateMay enhance the CNS depressant effect of CNS Depressants.
MefloquineMefloquine may diminish the therapeutic effect of Anticonvulsants. Mefloquine may decrease the serum concentration of Anticonvulsants.
MestranolContraceptives (Estrogens) may increase the serum concentration of TiZANidine.
MethohexitalMay enhance the hypotensive effect of Hypotensive Agents.
MethotrimeprazineCNS Depressants may enhance the CNS depressant effect of Methotrimeprazine. Methotrimeprazine may enhance the CNS depressant effect of CNS Depressants.
MetyrosineCNS Depressants may enhance the sedative effect of Metyrosine.
MifepristoneMay enhance the QTc-prolonging effect of QTc-Prolonging Agents (Indeterminate Risk and Risk Modifying).
MirtazapineMay diminish the antihypertensive effect of Alpha2-Agonists.
MoexiprilMay enhance the hypotensive effect of ACE Inhibitors.
NabiloneMay enhance the CNS depressant effect of CNS Depressants.
NorelgestrominContraceptives (Estrogens) may increase the serum concentration of TiZANidine.
OrlistatOrlistat may decrease the serum concentration of Anticonvulsants. Exceptions: Fosphenytoin; PENTobarbital; Thiopental.
OrphenadrineCNS Depressants may enhance the CNS depressant effect of Orphenadrine.
Peginterferon alfa-2bMay increase the serum concentration of CYP1A2 Substrates.
PentobarbitalMay enhance the hypotensive effect of Hypotensive Agents.
PerampanelMay enhance the CNS depressant effect of CNS Depressants.
PerindoprilMay enhance the hypotensive effect of ACE Inhibitors.
PramipexoleCNS Depressants may enhance the sedative effect of Pramipexole.
PrimidoneMay enhance the hypotensive effect of Hypotensive Agents.
QuinaprilMay enhance the hypotensive effect of ACE Inhibitors.
RamiprilMay enhance the hypotensive effect of ACE Inhibitors.
RisperidoneHypotensive Agents may enhance the hypotensive effect of RisperiDONE.
RopiniroleCNS Depressants may enhance the sedative effect of ROPINIRole.
RotigotineCNS Depressants may enhance the sedative effect of Rotigotine.
RufinamideMay enhance the adverse/toxic effect of CNS Depressants. Specifically, sleepiness and dizziness may be enhanced.
RuxolitinibMay enhance the bradycardic effect of Bradycardia-Causing Agents.
SecobarbitalMay enhance the hypotensive effect of Hypotensive Agents.
SuvorexantCNS Depressants may enhance the CNS depressant effect of Suvorexant.
TapentadolMay enhance the CNS depressant effect of CNS Depressants.
ThalidomideCNS Depressants may enhance the CNS depressant effect of Thalidomide.
TofacitinibMay enhance the bradycardic effect of Bradycardia-Causing Agents.
TrandolaprilMay enhance the hypotensive effect of ACE Inhibitors.
VemurafenibMay increase the serum concentration of CYP1A2 Substrates.
ZolpidemCNS Depressants may enhance the CNS depressant effect of Zolpidem.
Food InteractionsNot Available

Targets

1. Alpha-2A adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Alpha-2A adrenergic receptor P08913 Details

References:

  1. Piletz JE, Zhu H, Chikkala DN: Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. J Pharmacol Exp Ther. 1996 Nov;279(2):694-702. Pubmed

2. Alpha-2B adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Alpha-2B adrenergic receptor P18089 Details

References:

  1. Piletz JE, Zhu H, Chikkala DN: Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. J Pharmacol Exp Ther. 1996 Nov;279(2):694-702. Pubmed

3. Alpha-2C adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: agonist

Components

Name UniProt ID Details
Alpha-2C adrenergic receptor P18825 Details

References:

  1. Piletz JE, Zhu H, Chikkala DN: Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. J Pharmacol Exp Ther. 1996 Nov;279(2):694-702. Pubmed

4. Nischarin

Kind: protein

Organism: Human

Pharmacological action: no

Actions: agonist

Components

Name UniProt ID Details
Nischarin Q9Y2I1 Details

References:

  1. Rolon PA: Myxoglobulosis of the appendix. Int Surg. 1977 Jun-Jul;62(6-7):355-6. Pubmed

Enzymes

1. Cytochrome P450 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. Pubmed
  2. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  4. Shellenberger MK, Groves L, Shah J, Novack GD: A controlled pharmacokinetic evaluation of tizanidine and baclofen at steady state. Drug Metab Dispos. 1999 Feb;27(2):201-4. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on January 09, 2014 11:38