| Drug |
Interaction |
| Amiodarone |
Amiodarone may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Amlodipine |
Amlopidine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Benazepril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Captopril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Cilazapril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Cimetidine |
Cimetidine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Ciprofloxacin |
Ciprofloxacin increases the effect/toxicity of tizanidine |
| Ciprofloxacin |
Ciprofloxacin inhibits the metabolism and clearance of Tizanidine. Concomitant therapy is contraindicated. |
| Diclofenac |
Diclofenac may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Donepezil |
Possible antagonism of action |
| Enalapril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Ethanol |
Ethanol increases the adverse effects of Tizanidine. The CNS depressant effects of these agents are additive. |
| Ethinyl Estradiol |
Oral contraceptives decrease the clearance of Tizanidine. |
| Ethinyl Estradiol |
The contraceptive increases the effect of tizanidine |
| Fluoxetine |
Fluoxetine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Fluvoxamine |
Fluvoxamine increases the effect/toxicity of tizanidine |
| Fluvoxamine |
Fluvoxamine inhibits the metabolism and clearance of Tizanidine. Concomitant therapy is contraindicated. |
| Fosinopril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Galantamine |
Possible antagonism of action |
| Gemfibrozil |
Gemfibrozil may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Ketoconazole |
Ketoconazole may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Lidocaine |
Lidocaine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Lisinopril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Mestranol |
Oral contraceptives decrease the clearance of Tizanidine. |
| Mestranol |
The contraceptive increases the effect of tizanidine |
| Methoxsalen |
Methoxsalen may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Mexiletine |
Mexilitene may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Miconazole |
Miconazole may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Moexipril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Moxifloxacin |
Moxifloxacin may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Nifedipine |
Nifedipine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Norethindrone |
The contraceptive increases the effect of tizanidine |
| Norfloxacin |
Norfloxacin may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Ofloxacin |
Ofloxacin may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Perindopril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Primaquine |
Primaquine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Propafenone |
Propafenone may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Propofol |
Propofol may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Quinapril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Quinupristin |
This combination presents an increased risk of toxicity |
| Ramipril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Rivastigmine |
Possible antagonism of action |
| Spirapril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Thiabendazole |
Thiabendazole may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Ticlopidine |
Ticlopidine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |
| Trandolapril |
Tizanidine increases the risk of hypotension with the ACE inhibitor |
| Tranylcypromine |
Tranylcypromine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration. |