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Identification
NameLisinopril
Accession NumberDB00722  (APRD00560)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.

Structure
Thumb
Synonyms
SynonymLanguageCode
(S)-1-(N(2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-prolineNot AvailableNot Available
[N2-[(S)-1-CARBOXY-3-phenylpropyl]-L-lysyl-L-prolineNot AvailableNot Available
LisinoprilFrench/German/SpanishINN
Lisinopril anhydrousNot AvailableNot Available
LisinoprilumLatinINN
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Priniviltablet5 mgoralMerck Sharp & Dohme Corp.1987-12-29Not AvailableUs
Priniviltablet10 mgoralMerck Sharp & Dohme Corp.1987-12-29Not AvailableUs
Priniviltablet20 mgoralMerck Sharp & Dohme Corp.1987-12-29Not AvailableUs
Zestriltablet5 mgoralAstra Zeneca Pharmaceuticals Lp2009-11-11Not AvailableUs
Zestriltablet10 mgoralAstra Zeneca Pharmaceuticals Lp2009-08-28Not AvailableUs
Zestriltablet20 mgoralAstra Zeneca Pharmaceuticals Lp2009-05-13Not AvailableUs
Zestriltablet30 mgoralAstra Zeneca Pharmaceuticals Lp2010-09-22Not AvailableUs
Zestriltablet40 mgoralAstra Zeneca Pharmaceuticals Lp2010-03-26Not AvailableUs
Zestriltablet2.5 mgoralAstra Zeneca Pharmaceuticals Lp2011-09-02Not AvailableUs
Zestriltablet20 mgoralPd Rx Pharmaceuticals, Inc.2011-11-09Not AvailableUs
Priniviltablet5 mgoralMerck Canada IncNot AvailableNot AvailableCanada
Priniviltablet10 mgoralMerck Canada IncNot AvailableNot AvailableCanada
Priniviltablet20 mgoralMerck Canada IncNot AvailableNot AvailableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Lisinopriltablet2.5 mgoralWest ward Pharmaceutical Corp2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralWest ward Pharmaceutical Corp2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralWest ward Pharmaceutical Corp2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralWest ward Pharmaceutical Corp2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralWest ward Pharmaceutical Corp2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralWest ward Pharmaceutical Corp2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralWest ward Pharmaceutical Corp2013-02-13Not AvailableUs
Lisinopriltablet10 mgoralWest ward Pharmaceutical Corp2013-02-13Not AvailableUs
Lisinopriltablet5 mgoralWest ward Pharmaceutical Corp2013-02-13Not AvailableUs
Lisinopriltablet2.5 mgoralWest ward Pharmaceutical Corp2013-02-13Not AvailableUs
Lisinopriltablet2.5 mgoralIVAX Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralIVAX Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralIVAX Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralIVAX Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralIVAX Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralIVAX Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralKAISER FOUNDATION HOSPITALS2013-08-05Not AvailableUs
Lisinopriltablet40 mgoralKAISER FOUNDATION HOSPITALS2008-11-03Not AvailableUs
Lisinopriltablet20 mgoralKAISER FOUNDATION HOSPITALS2008-11-03Not AvailableUs
Lisinopriltablet5 mgoralKAISER FOUNDATION HOSPITALS2008-11-03Not AvailableUs
Lisinopriltablet2.5 mgoralEon Labs, Inc.2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralEon Labs, Inc.2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralEon Labs, Inc.2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralEon Labs, Inc.2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralEon Labs, Inc.2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralEon Labs, Inc.2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralMylan Pharmaceuticals Inc.2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralMylan Pharmaceuticals Inc.2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralMylan Pharmaceuticals Inc.2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralMylan Pharmaceuticals Inc.2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralMylan Pharmaceuticals Inc.2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralMylan Pharmaceuticals Inc.2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralLiberty Pharmaceuticals, Inc.2007-04-19Not AvailableUs
Lisinopriltablet2.5 mgoralWatson Laboratories, Inc.2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralWatson Laboratories, Inc.2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralWatson Laboratories, Inc.2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralWatson Laboratories, Inc.2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralWatson Laboratories, Inc.2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralWatson Laboratories, Inc.2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralQualitest Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralQualitest Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralQualitest Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralQualitest Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralQualitest Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralQualitest Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not AvailableUs
Lisinopriltablet5 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not AvailableUs
Lisinopriltablet20 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not AvailableUs
Lisinopriltablet2.5 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not AvailableUs
Lisinopriltablet30 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not AvailableUs
Lisinopriltablet40 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not AvailableUs
Lisinopriltablet, film coated2.5 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not AvailableUs
Lisinopriltablet, film coated5 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not AvailableUs
Lisinopriltablet, film coated10 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not AvailableUs
Lisinopriltablet, film coated20 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not AvailableUs
Lisinopriltablet, film coated30 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not AvailableUs
Lisinopriltablet, film coated40 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not AvailableUs
Lisinopriltablet2.5 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-02Not AvailableUs
Lisinopriltablet5 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralMajor Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralMajor Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralMajor Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralMajor Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralBlenheim Pharmacal, Inc.2009-12-16Not AvailableUs
Lisinopriltablet20 mgoralBlenheim Pharmacal, Inc.2009-12-16Not AvailableUs
Lisinopriltablet40 mgoralBlenheim Pharmacal, Inc.2010-05-20Not AvailableUs
Lisinopriltablet5 mgoralBlenheim Pharmacal, Inc.2014-01-15Not AvailableUs
Lisinopriltablet10 mgoralSTAT Rx USA LLC2005-11-17Not AvailableUs
Lisinopriltablet20 mgoralSTAT Rx USA LLC2007-04-19Not AvailableUs
Lisinopriltablet40 mgoralSTAT Rx USA LLC2007-04-19Not AvailableUs
Lisinopriltablet2.5 mgoralAccord Healthcare Inc.2013-09-15Not AvailableUs
Lisinopriltablet5 mgoralAccord Healthcare Inc.2013-09-15Not AvailableUs
Lisinopriltablet10 mgoralAccord Healthcare Inc.2013-09-15Not AvailableUs
Lisinopriltablet20 mgoralAccord Healthcare Inc.2013-09-15Not AvailableUs
Lisinopriltablet30 mgoralAccord Healthcare Inc.2013-09-15Not AvailableUs
Lisinopriltablet40 mgoralAccord Healthcare Inc.2013-09-15Not AvailableUs
Lisinopriltablet5 mgoralRebel Distributors Corp2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralRebel Distributors Corp2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralRebel Distributors Corp2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralRebel Distributors Corp2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralRebel Distributors Corp2008-02-01Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-09-19Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2014-04-16Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-05-20Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-02-28Not AvailableUs
Lisinopriltablet2.5 mgoralBlu Pharmaceuticals, LLC2009-02-02Not AvailableUs
Lisinopriltablet5 mgoralBlu Pharmaceuticals, LLC2009-02-02Not AvailableUs
Lisinopriltablet10 mgoralBlu Pharmaceuticals, LLC2009-02-02Not AvailableUs
Lisinopriltablet20 mgoralBlu Pharmaceuticals, LLC2009-02-02Not AvailableUs
Lisinopriltablet30 mgoralBlu Pharmaceuticals, LLC2009-02-02Not AvailableUs
Lisinopriltablet40 mgoralBlu Pharmaceuticals, LLC2009-02-02Not AvailableUs
Lisinopriltablet2.5 mgoralCamber Pharmaceuticals Inc.2013-11-15Not AvailableUs
Lisinopriltablet5 mgoralCamber Pharmaceuticals Inc.2013-11-15Not AvailableUs
Lisinopriltablet10 mgoralCamber Pharmaceuticals Inc.2013-11-15Not AvailableUs
Lisinopriltablet20 mgoralCamber Pharmaceuticals Inc.2013-11-15Not AvailableUs
Lisinopriltablet30 mgoralCamber Pharmaceuticals Inc.2013-11-15Not AvailableUs
Lisinopriltablet40 mgoralCamber Pharmaceuticals Inc.2013-11-15Not AvailableUs
Lisinopriltablet40 mgoralAidarex Pharmaceuticals LLC2006-01-13Not AvailableUs
Lisinopriltablet20 mgoralAidarex Pharmaceuticals LLC2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralAidarex Pharmaceuticals LLC2006-01-13Not AvailableUs
Lisinopriltablet5 mgoralAidarex Pharmaceuticals LLC2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralAidarex Pharmaceuticals LLC2006-01-13Not AvailableUs
Lisinopriltablet5 mgoralRx Change Co.2014-11-18Not AvailableUs
Lisinopriltablet10 mgoralRx Change Co.2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralRx Change Co.2014-11-12Not AvailableUs
Lisinopriltablet5 mgoralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not AvailableUs
Lisinopriltablet40 mgoralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not AvailableUs
Lisinopriltablet2.5 mgoralLake Erie Medical DBA Quality Care Products LLC2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralPd Rx Pharmaceuticals, Inc.2006-01-13Not AvailableUs
Lisinopriltablet2.5 mgoralPd Rx Pharmaceuticals, Inc.2002-07-02Not AvailableUs
Lisinopriltablet10 mgoralPd Rx Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralPd Rx Pharmaceuticals, Inc.2006-01-13Not AvailableUs
Lisinopriltablet20 mgoralPd Rx Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralPd Rx Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralPd Rx Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralAphena Pharma Solutions Tennessee, Llc2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralAphena Pharma Solutions Tennessee, Llc2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralSolco healthcare U.S., LLC2011-11-01Not AvailableUs
Lisinopriltablet5 mgoralSolco healthcare U.S., LLC2011-11-01Not AvailableUs
Lisinopriltablet10 mgoralSolco healthcare U.S., LLC2011-11-01Not AvailableUs
Lisinopriltablet20 mgoralSolco healthcare U.S., LLC2011-11-01Not AvailableUs
Lisinopriltablet30 mgoralSolco healthcare U.S., LLC2011-11-01Not AvailableUs
Lisinopriltablet40 mgoralSolco healthcare U.S., LLC2011-11-01Not AvailableUs
Lisinopriltablet10 mgoralSafecor Health, LLC2014-09-30Not AvailableUs
Lisinopriltablet5 mgoralREMEDYREPACK INC.2010-09-16Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2010-11-10Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-05-21Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-11-05Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2012-08-27Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2010-11-15Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-05-21Not AvailableUs
Lisinopriltablet40 mgoralREMEDYREPACK INC.2011-04-20Not AvailableUs
Lisinopriltablet40 mgoralREMEDYREPACK INC.2013-04-05Not AvailableUs
Lisinopriltablet40 mgoralREMEDYREPACK INC.2011-04-14Not AvailableUs
Lisinopriltablet5 mgoralREMEDYREPACK INC.2011-03-29Not AvailableUs
Lisinopriltablet30 mgoralREMEDYREPACK INC.2011-06-21Not AvailableUs
Lisinopriltablet2.5 mgoralREMEDYREPACK INC.2011-07-13Not AvailableUs
Lisinopriltablet30 mgoralREMEDYREPACK INC.2011-07-19Not AvailableUs
Lisinopriltablet5 mgoralREMEDYREPACK INC.2013-09-27Not AvailableUs
Lisinopriltablet5 mgoralREMEDYREPACK INC.2011-05-19Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-12-04Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-04-09Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-06-24Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-04-04Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2011-09-29Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-12-05Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2011-09-29Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-06-24Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2012-08-31Not AvailableUs
Lisinopriltablet10 mgoralLake Erie Medical Quality Care Products LLC2012-03-27Not AvailableUs
Lisinopriltablet20 mgoralLake Erie Medical DBA Quality Care Products LLC2011-07-19Not AvailableUs
Lisinopriltablet40 mgoralLake Erie Medical Quality Care Products LLC2012-03-27Not AvailableUs
Lisinopriltablet30 mgoralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not AvailableUs
Lisinopriltablet5 mgoralUnit Dose Services2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralUnit Dose Services2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralUnit Dose Services2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralUnit Dose Services2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralUnit Dose Services2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralUnit Dose Services2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralMylan Institutional Inc.2012-08-27Not AvailableUs
Lisinopriltablet10 mgoralMylan Institutional Inc.2012-08-27Not AvailableUs
Lisinopriltablet20 mgoralMylan Institutional Inc.2012-08-27Not AvailableUs
Lisinopriltablet40 mgoralMylan Institutional Inc.2012-08-27Not AvailableUs
Lisinopriltablet2.5 mgoralMed Health Pharma, LLC2011-01-05Not AvailableUs
Lisinopriltablet5 mgoralMed Health Pharma, LLC2011-01-05Not AvailableUs
Lisinopriltablet10 mgoralMed Health Pharma, LLC2011-01-05Not AvailableUs
Lisinopriltablet20 mgoralMed Health Pharma, LLC2011-01-05Not AvailableUs
Lisinopriltablet30 mgoralMed Health Pharma, LLC2011-01-05Not AvailableUs
Lisinopriltablet40 mgoralMed Health Pharma, LLC2011-01-05Not AvailableUs
Lisinopriltablet5 mgoralNorthwind Pharmaceuticals, LLC2014-07-30Not AvailableUs
Lisinopriltablet10 mg/301oralNorthwind Pharmaceuticals2014-05-20Not AvailableUs
Lisinopriltablet10 1oralNorthwind Pharmaceuticals, LLC2014-11-17Not AvailableUs
Lisinopriltablet20 mgoralNorthwind Pharmaceuticals, LLC2014-11-21Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-02-26Not AvailableUs
Lisinopriltablet2.5 mgoralREMEDYREPACK INC.2013-03-18Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-03-20Not AvailableUs
Lisinopriltablet5 mgoralREMEDYREPACK INC.2012-12-31Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-07-05Not AvailableUs
Lisinopriltablet2.5 mgoralREMEDYREPACK INC.2013-05-08Not AvailableUs
Lisinopriltablet5 mgoralREMEDYREPACK INC.2013-05-08Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-05-08Not AvailableUs
Lisinopriltablet40 mgoralREMEDYREPACK INC.2013-11-05Not AvailableUs
Lisinopriltablet40 mgoralREMEDYREPACK INC.2013-05-13Not AvailableUs
Lisinopriltablet40 mgoralREMEDYREPACK INC.2013-05-14Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-05-16Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-06-24Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2013-11-05Not AvailableUs
Lisinopriltablet20 mgoralREMEDYREPACK INC.2014-09-15Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-05-28Not AvailableUs
Lisinopriltablet10 mgoralREMEDYREPACK INC.2013-05-28Not AvailableUs
Lisinopriltablet5 mgoralREMEDYREPACK INC.2014-04-04Not AvailableUs
Lisinopriltablet10 mgoralH.J. Harkins Company, Inc.2005-11-17Not AvailableUs
Lisinopriltablet2.5 mgoralAidarex Pharmaceuticals LLC2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Lisinopriltablet5 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Lisinopriltablet20 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Lisinopriltablet40 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs
Lisinopriltablet10 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Lisinopriltablet20 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Lisinopriltablet20 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Lisinopriltablet20 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs
Lisinopriltablet10 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs
Lisinopriltablet2.5 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs
Lisinopriltablet40 mgoralState of Florida DOH Central Pharmacy2013-01-01Not AvailableUs
Lisinopriltablet30 mgoralState of Florida DOH Central Pharmacy2014-01-01Not AvailableUs
Lisinopriltablet40 mgoralState of Florida DOH Central Pharmacy2014-11-01Not AvailableUs
Lisinopriltablet40 mgoralInternational Labs, Inc.2012-02-20Not AvailableUs
Lisinopriltablet5 mgoralInternational Labs, Inc.2012-02-20Not AvailableUs
Lisinopriltablet40 mgoralInternational Labs, Inc.2008-02-01Not AvailableUs
Lisinopriltablet30 mgoralInternational Labs, Inc.2008-02-01Not AvailableUs
Lisinopriltablet20 mgoralInternational Labs, Inc.2008-02-01Not AvailableUs
Lisinopriltablet10 mgoralInternational Labs, Inc.2008-02-01Not AvailableUs
Lisinopriltablet5 mgoralInternational Labs, Inc.2008-02-01Not AvailableUs
Lisinopriltablet2.5 mgoralInternational Labs, Inc.2008-02-01Not AvailableUs
Lisinopriltablet40 mgoralPhysicians Total Care, Inc.2004-08-25Not AvailableUs
Lisinopriltablet2.5 mgoralPhysicians Total Care, Inc.2009-02-16Not AvailableUs
Lisinopriltablet10 mgoralPhysicians Total Care, Inc.2005-07-25Not AvailableUs
Lisinopriltablet20 mgoralPhysicians Total Care, Inc.2007-09-17Not AvailableUs
Lisinopriltablet5 mgoralPhysicians Total Care, Inc.2008-04-10Not AvailableUs
Lisinopriltablet30 mgoralPhysicians Total Care, Inc.2007-04-12Not AvailableUs
Lisinopriltablet5 mgoralCardinal Health2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralCardinal Health2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralCardinal Health2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralCardinal Health2005-09-22Not AvailableUs
Lisinopriltablet20 mgoralCardinal Health2013-12-23Not AvailableUs
Lisinopriltablet5 mgoralCardinal Health2013-12-23Not AvailableUs
Lisinopriltablet5 mgoralCardinal Health2012-08-27Not AvailableUs
Lisinopriltablet10 mgoralCardinal Health2012-08-27Not AvailableUs
Lisinopriltablet20 mgoralCardinal Health2012-08-27Not AvailableUs
Lisinopriltablet40 mgoralCardinal Health2012-08-27Not AvailableUs
Lisinopriltablet20 mgoralCardinal Health2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralCardinal Health2009-12-18Not AvailableUs
Lisinopriltablet20 mgoralCardinal Health2009-12-18Not AvailableUs
Lisinopriltablet5 mgoralCardinal Health2009-12-18Not AvailableUs
Lisinopriltablet40 mgoralCardinal Health2009-12-18Not AvailableUs
Lisinopriltablet2.5 mgoralCardinal Health2009-12-18Not AvailableUs
Lisinopriltablet10 mgoralCardinal Health2012-10-05Not AvailableUs
Lisinopriltablet20 mgoralCardinal Health2012-10-05Not AvailableUs
Lisinopriltablet2.5 mgoralCardinal Health2012-10-05Not AvailableUs
Lisinopriltablet40 mgoralCardinal Health2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralCardinal Health2012-10-05Not AvailableUs
Lisinopriltablet5 mgoralCardinal Health2005-09-22Not AvailableUs
Lisinopriltablet10 mgoralCardinal Health2005-09-22Not AvailableUs
Lisinopriltablet2.5 mgoralCardinal Health2006-01-13Not AvailableUs
Lisinopriltablet5 mgoralCardinal Health2006-01-13Not AvailableUs
Lisinopriltablet10 mgoralCardinal Health2006-01-13Not AvailableUs
Lisinopriltablet20 mgoralCardinal Health2006-01-13Not AvailableUs
Lisinopriltablet40 mgoralCardinal Health2006-01-13Not AvailableUs
Lisinopriltablet10 mgoralPd Rx Pharmaceuticals, Inc.2005-11-17Not AvailableUs
Lisinopriltablet20 mgoralPd Rx Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralPd Rx Pharmaceuticals, Inc.2005-11-17Not AvailableUs
Lisinopriltablet40 mgoralPd Rx Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralWockhardt Limited2007-04-19Not AvailableUs
Lisinopriltablet5 mgoralWockhardt Limited2007-04-19Not AvailableUs
Lisinopriltablet10 mgoralWockhardt Limited2007-04-19Not AvailableUs
Lisinopriltablet20 mgoralWockhardt Limited2007-04-19Not AvailableUs
Lisinopriltablet40 mgoralWockhardt Limited2007-04-19Not AvailableUs
Lisinopriltablet30 mgoralWockhardt Limited2007-04-19Not AvailableUs
Lisinopriltablet2.5 mgoralCitron Pharma LLC2006-02-22Not AvailableUs
Lisinopriltablet5 mgoralCitron Pharma LLC2006-02-22Not AvailableUs
Lisinopriltablet10 mgoralCitron Pharma LLC2006-02-22Not AvailableUs
Lisinopriltablet20 mgoralCitron Pharma LLC2006-02-22Not AvailableUs
Lisinopriltablet30 mgoralCitron Pharma LLC2006-02-22Not AvailableUs
Lisinopriltablet40 mgoralCitron Pharma LLC2006-02-22Not AvailableUs
Lisinopriltablet2.5 mgoralClinical Solutions Wholesale2006-01-13Not AvailableUs
Lisinopriltablet5 mgoralClinical Solutions Wholesale2006-01-13Not AvailableUs
Lisinopriltablet10 mgoralClinical Solutions Wholesale2006-01-13Not AvailableUs
Lisinopriltablet20 mgoralClinical Solutions Wholesale2006-01-13Not AvailableUs
Lisinopriltablet40 mgoralClinical Solutions Wholesale2006-01-13Not AvailableUs
Lisinopriltablet2.5 mgoralHikma Pharmaceutical2013-08-22Not AvailableUs
Lisinopriltablet5 mgoralHikma Pharmaceutical2013-08-22Not AvailableUs
Lisinopriltablet10 mgoralHikma Pharmaceutical2013-08-22Not AvailableUs
Lisinopriltablet20 mgoralHikma Pharmaceutical2013-08-22Not AvailableUs
Lisinopriltablet2.5 mgoralApotex Corp.2008-06-26Not AvailableUs
Lisinopriltablet5 mgoralApotex Corp.2008-02-18Not AvailableUs
Lisinopriltablet10 mgoralApotex Corp.2008-04-17Not AvailableUs
Lisinopriltablet20 mgoralApotex Corp.2008-06-25Not AvailableUs
Lisinopriltablet30 mgoralApotex Corp.2002-10-09Not AvailableUs
Lisinopriltablet40 mgoralApotex Corp.2008-01-22Not AvailableUs
Lisinopriltablet20 mgoralSt Marys Medical Park Pharmacy2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralSt Marys Medical Park Pharmacy2014-04-21Not AvailableUs
Lisinopriltablet5 mgoralSt Marys Medical Park Pharmacy2013-05-16Not AvailableUs
Lisinopriltablet10 mgoralSt Marys Medical Park Pharmacy2002-07-01Not AvailableUs
Lisinopriltablet30 mgoralSt Marys Medical Park Pharmacy2014-04-21Not AvailableUs
Lisinopriltablet40 mgoralSt Marys Medical Park Pharmacy2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralDIRECT RX2014-01-01Not AvailableUs
Lisinopriltablet20 mgoralDIRECT RX2014-01-01Not AvailableUs
Lisinopriltablet10 mgoralProficient Rx LP2006-01-13Not AvailableUs
Lisinopriltablet20 mgoralProficient Rx LP2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralProficient Rx LP2006-01-13Not AvailableUs
Lisinopriltablet20 mgoralProficient Rx LP2006-01-13Not AvailableUs
Lisinopriltablet2.5 mgoralRanbaxy Pharmaceuticals Inc.2002-07-02Not AvailableUs
Lisinopriltablet5 mgoralRanbaxy Pharmaceuticals Inc.2002-07-02Not AvailableUs
Lisinopriltablet10 mgoralRanbaxy Pharmaceuticals Inc.2002-07-02Not AvailableUs
Lisinopriltablet20 mgoralRanbaxy Pharmaceuticals Inc.2002-07-02Not AvailableUs
Lisinopriltablet40 mgoralRanbaxy Pharmaceuticals Inc.2002-07-02Not AvailableUs
Lisinopriltablet30 mgoralRanbaxy Pharmaceuticals Inc.2006-05-15Not AvailableUs
Lisinopriltablet5 mgoralbryant ranch prepack2005-11-17Not AvailableUs
Lisinopriltablet10 mgoralbryant ranch prepack2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralbryant ranch prepack2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralbryant ranch prepack2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralbryant ranch prepack2006-01-13Not AvailableUs
Lisinopriltablet10 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralReady Meds2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralReady Meds2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralReady Meds2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralReady Meds2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralWockhardt USA LLC.2007-04-19Not AvailableUs
Lisinopriltablet5 mgoralWockhardt USA LLC.2007-04-19Not AvailableUs
Lisinopriltablet10 mgoralWockhardt USA LLC.2007-04-19Not AvailableUs
Lisinopriltablet20 mgoralWockhardt USA LLC.2007-04-19Not AvailableUs
Lisinopriltablet40 mgoralWockhardt USA LLC.2007-04-19Not AvailableUs
Lisinopriltablet30 mgoralWockhardt USA LLC.2007-04-19Not AvailableUs
Lisinopriltablet10 mgoralTYA Pharmaceuticals2006-01-13Not AvailableUs
Lisinopriltablet20 mgoralTYA Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet20 mgoralTYA Pharmaceuticals2006-01-13Not AvailableUs
Lisinopriltablet5 mgoralTYA Pharmaceuticals2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralAurobindo Pharma Limited2006-02-22Not AvailableUs
Lisinopriltablet5 mgoralAurobindo Pharma Limited2006-02-22Not AvailableUs
Lisinopriltablet10 mgoralAurobindo Pharma Limited2006-02-22Not AvailableUs
Lisinopriltablet20 mgoralAurobindo Pharma Limited2006-02-22Not AvailableUs
Lisinopriltablet30 mgoralAurobindo Pharma Limited2006-02-22Not AvailableUs
Lisinopriltablet40 mgoralAurobindo Pharma Limited2006-02-22Not AvailableUs
Lisinopriltablet20 mgoralMed Vantx, Inc.2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralMed Vantx, Inc.2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralMed Vantx, Inc.2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralContract Pharmacy Services Pa2010-08-12Not AvailableUs
Lisinopriltablet10 mgoralContract Pharmacy Services Pa2002-07-02Not AvailableUs
Lisinopriltablet20 mgoralContract Pharmacy Services Pa2010-08-12Not AvailableUs
Lisinopriltablet20 mgoralContract Pharmacy Services Pa2002-08-02Not AvailableUs
Lisinopriltablet20 mgoralRed Pharm Drug Inc.2002-07-02Not AvailableUs
Lisinopriltablet10 mgoralRed Pharm Drug Inc.2005-11-17Not AvailableUs
Lisinopriltablet20 mgoralRed Pharm Drug Inc.2002-07-01Not AvailableUs
Lisinopriltablet5 mgoralBlue Point Laboratories2014-02-04Not AvailableUs
Lisinopriltablet20 mgoralBlue Point Laboratories2002-07-01Not AvailableUs
Lisinopriltablet40 mgoralBlue Point Laboratories2014-02-04Not AvailableUs
Lisinopriltablet10 mgoralBlue Point Laboratories2014-02-04Not AvailableUs
Lisinopriltablet2.5 mgoralBlue Point Laboratories2014-02-05Not AvailableUs
Lisinopriltablet30 mgoralBlue Point Laboratories2014-02-04Not AvailableUs
Lisinopriltablet5 mgoralAmerican Health Packaging2005-09-22Not AvailableUs
Lisinopriltablet10 mgoralAmerican Health Packaging2005-09-22Not AvailableUs
Lisinopriltablet20 mgoralAmerican Health Packaging2005-09-22Not AvailableUs
Lisinopriltablet40 mgoralAmerican Health Packaging2005-09-222015-12-05Us
Lisinopriltablet5 mgoralAmerican Health Packaging2013-12-23Not AvailableUs
Lisinopriltablet10 mgoralAmerican Health Packaging2013-12-23Not AvailableUs
Lisinopriltablet20 mgoralAmerican Health Packaging2013-12-23Not AvailableUs
Lisinopriltablet40 mgoralAmerican Health Packaging2013-12-23Not AvailableUs
Lisinopriltablet2.5 mgoralAmerican Health Packaging2014-06-02Not AvailableUs
Lisinopriltablet30 mgoralAmerican Health Packaging2014-12-15Not AvailableUs
Lisinopriltablet2.5 mgoralCarilion Materials Management2002-07-01Not AvailableUs
Lisinopriltablet2.5 mgoralLupin Pharmaceuticals, Inc.2006-01-13Not AvailableUs
Lisinopriltablet5 mgoralLupin Pharmaceuticals, Inc.2006-01-13Not AvailableUs
Lisinopriltablet10 mgoralLupin Pharmaceuticals, Inc.2006-01-13Not AvailableUs
Lisinopriltablet20 mgoralLupin Pharmaceuticals, Inc.2006-01-13Not AvailableUs
Lisinopriltablet30 mgoralLupin Pharmaceuticals, Inc.2006-01-13Not AvailableUs
Lisinopriltablet40 mgoralLupin Pharmaceuticals, Inc.2006-01-13Not AvailableUs
Lisinopriltablet2.5 mgoralDispensing Solutions, Inc.2005-11-17Not AvailableUs
Lisinopriltablet20 mgoralKeltman Pharmaceuticals Inc.2010-12-10Not AvailableUs
Lisinopriltablet20 mgoralLegacy Pharmaceutical Packaging2010-10-01Not AvailableUs
Lisinopriltablet20 mgoralLegacy Pharmaceutical Packaging2006-01-13Not AvailableUs
Lisinopriltablet10 mgoralPreferred Pharmaceuticals, Inc.2013-05-02Not AvailableUs
Lisinopriltablet5 mgoralPreferred Pharmaceuticals, Inc.2013-12-03Not AvailableUs
Lisinopriltablet20 mgoralPreferred Pharmaceuticals, Inc.2002-07-01Not AvailableUs
Lisinopriltablet10 mgoralPreferred Pharmaceuticals, Inc.2013-12-03Not AvailableUs
Lisinopriltablet5 mgoralPreferred Pharmaceuticals, Inc.2012-01-30Not AvailableUs
Lisinopriltablet40 mgoralPreferred Pharmaceuticals, Inc2012-04-05Not AvailableUs
Lisinopriltablet20 mgoralPreferred Pharmaceuticals, Inc2012-04-05Not AvailableUs
Lisinopriltablet10 mgoralPreferred Pharmaceuticals, Inc2012-04-05Not AvailableUs
Lisinopriltablet40 mgoralPreferred Pharmaceuticals, Inc.2012-01-30Not AvailableUs
Lisinopriltablet20 mgoralPreferred Pharmaceuticals, Inc.2012-01-30Not AvailableUs
Lisinopriltablet10 mgoralPreferred Pharmaceuticals, Inc.2012-01-30Not AvailableUs
Lisinopriltablet20 mgoralLife Line Home Care Services, Inc.2010-08-12Not AvailableUs
Lisinopriltablet2.5 mgoralMc Kesson Contract Packaging2011-09-01Not AvailableUs
Lisinopriltablet5 mgoralMc Kesson Contract Packaging2011-09-07Not AvailableUs
Lisinopriltablet10 mgoralMc Kesson Contract Packaging2011-09-08Not AvailableUs
Lisinopriltablet20 mgoralMc Kesson Contract Packaging2011-09-09Not AvailableUs
Lisinopriltablet40 mgoralMc Kesson Contract Packaging2011-09-16Not AvailableUs
Lisinopril 2.5mgtablet2.5 mgoralMcKesson Contract Packaging2013-08-01Not AvailableUs
Lisinopril 5mgtablet5 mgoralMcKesson Contract Packaging2013-08-01Not AvailableUs
Lisinopril 10mgtablet10 mgoralMcKesson Contract Packaging2013-08-01Not AvailableUs
Lisinopril 20mgtablet20 mgoralMcKesson Contract Packaging2013-08-01Not AvailableUs
Lisinopril 40mgtablet40 mgoralMcKesson Contract Packaging2013-08-01Not AvailableUs
Lisinopriltablet2.5 mgoralExelan Pharmaceuticals Inc.2014-03-15Not AvailableUs
Lisinopriltablet5 mgoralExelan Pharmaceuticals Inc.2014-03-15Not AvailableUs
Lisinopriltablet10 mgoralExelan Pharmaceuticals Inc.2014-03-15Not AvailableUs
Lisinopriltablet20 mgoralExelan Pharmaceuticals Inc.2014-03-15Not AvailableUs
Lisinopriltablet30 mgoralExelan Pharmaceuticals Inc.2014-03-15Not AvailableUs
Lisinopriltablet40 mgoralExelan Pharmaceuticals Inc.2014-03-15Not AvailableUs
Lisinopriltablet5 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Lisinopriltablet10 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Lisinopriltablet20 mgoralSivem Pharmaceuticals UlcNot AvailableNot AvailableCanada
Over the Counter ProductsNot Available
International Brands
NameCompany
AcebitorGlaxoSmithKline
AceminAstraZeneca
AcerbonAstraZeneca
Acinoprilsanofi-aventis
BellisinRanbaxy
BioprilBiochem
DaprilMedochemie
FibsolSigma
FisoprilSanofi-Aventis
HiprilMicro Labs
LinoprilKlinger (Brazil)
LisiprilHexal (Czech Republic), Orion (Finland)
NopertenDexa (Indonesia)
PresitenMagnachem
RanolipRanbaxy
RanoprilRanbaxy
RantexBiotech
SinoprenRanbaxy
SinoprilEczacibasi (Russia)
TensoprilMerck
Brand mixtures
Brand NameIngredients
AcercompLisinopril and Hydrochlorothiazide
Acerdil DLisinopril and Hydrochlorothiazide
Adco-Zetomax COLisinopril and Hydrochlorothiazide
Amchek LLisinopril and Amlodipine
AmlaceLisinopril and Amlodipine
Amlodac-LLisinopril and Amlodipine
Amlopres-L Lisinopril and Amlodipine
Amlot-LLisinopril and Amlodipine
Amlovas-LLisinopril and Amlodipine
Amtas-LPLisinopril and Amlodipine
Lisinopril Complisinopril + hydrochlorothiazide
Prinzidelisinopril + hydrochlorothiazide
Zestoretic Tab 10/12.5mglisinopril + hydrochlorothiazide
Zestoretic Tab 20/12.5mglisinopril + hydrochlorothiazide
Zestoretic Tab 20/25mglisinopril + hydrochlorothiazide
SaltsNot Available
CategoriesNot Available
CAS number83915-83-7
WeightAverage: 405.4879
Monoisotopic: 405.226371117
Chemical FormulaC21H31N3O5
InChI KeyRLAWWYSOJDYHDC-BZSNNMDCSA-N
InChI
InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1
IUPAC Name
(2S)-1-[(2S)-6-amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]pyrrolidine-2-carboxylic acid
SMILES
NCCCC[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentPeptides
Alternative Parents
Substituents
  • Alpha peptide
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Alpha-amino acid amide
  • L-alpha-amino acid
  • Phenylpropylamine
  • Alpha-amino acid or derivatives
  • N-substituted-alpha-amino acid
  • Alpha-amino acid
  • Pyrrolidine carboxylic acid or derivatives
  • Pyrrolidine carboxylic acid
  • N-acylpyrrolidine
  • Aralkylamine
  • Amino fatty acid
  • Fatty acyl
  • Benzenoid
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Tertiary amine
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Secondary aliphatic amine
  • Carboxylic acid
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
PharmacodynamicsLisinopril is an orally active ACE inhibitor that antagonizes the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may further sustain the effects of lisinopril by causing increased vasodilation and decreased blood pressure.
Mechanism of actionThere are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Lisinopril, one of the few ACE inhibitors that is not a prodrug, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Lisinopril also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors.
AbsorptionApproximately 25%, but widely variable between individuals (6 to 60%) in all doses tested (5-80 mg); absorption is unaffected by food
Volume of distributionNot Available
Protein bindingLisinopril does not appear to be bound to serum proteins other than ACE.
Metabolism

Does not undergo metabolism, excreted unchanged in urine.

Route of eliminationLisinopril does not undergo metabolism and is excreted unchanged entirely in the urine.
Half lifeEffective half life of accumulation following multiple dosing is 12 hours.
Clearance
  • 10 L/h [child weighting 30 kg receiving doses of 0.1 to 0.2 mg/kg]
ToxicitySymptoms of overdose include severe hypotension, electrolyte disturbances, and renal failure. LD50= 2000 mg/kg(orally in rat). Most frequent adverse effects include headache, dizziness, cough, fatigue and diarrhea.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Lisinopril Action PathwayDrug actionSMP00150
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6426
Blood Brain Barrier-0.8815
Caco-2 permeable-0.7605
P-glycoprotein substrateSubstrate0.6515
P-glycoprotein inhibitor INon-inhibitor0.9512
P-glycoprotein inhibitor IINon-inhibitor0.969
Renal organic cation transporterNon-inhibitor0.8574
CYP450 2C9 substrateNon-substrate0.8793
CYP450 2D6 substrateNon-substrate0.7622
CYP450 3A4 substrateNon-substrate0.725
CYP450 1A2 substrateNon-inhibitor0.8999
CYP450 2C9 substrateNon-inhibitor0.9708
CYP450 2D6 substrateNon-inhibitor0.9653
CYP450 2C19 substrateNon-inhibitor0.8266
CYP450 3A4 substrateNon-inhibitor0.907
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9821
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9389
BiodegradationNot ready biodegradable0.6844
Rat acute toxicity1.8723 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9641
hERG inhibition (predictor II)Non-inhibitor0.8708
Pharmacoeconomics
Manufacturers
  • Actavis elizabeth llc
  • Apotex inc etobicoke site
  • Aurobindo pharma ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lek pharmaceuticals d d
  • Lupin ltd
  • Mylan pharmaceuticals inc
  • Ranbaxy pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Vintage pharmaceuticals llc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Wockhardt ltd
  • Merck research laboratories div merck co inc
  • Astrazeneca uk ltd
Packagers
Dosage forms
FormRouteStrength
Tabletoral10 1
Tabletoral10 mg
Tabletoral10 mg/301
Tabletoral2.5 mg
Tabletoral20 mg
Tabletoral30 mg
Tabletoral40 mg
Tabletoral5 mg
Tablet, film coatedoral10 mg
Tablet, film coatedoral2.5 mg
Tablet, film coatedoral20 mg
Tablet, film coatedoral30 mg
Tablet, film coatedoral40 mg
Tablet, film coatedoral5 mg
Prices
Unit descriptionCostUnit
Prinivil 90 20 mg tablet Bottle111.71USD bottle
Prinzide 30 20-12.5 mg tablet Bottle45.99USD bottle
Prinivil 30 2.5 mg tablet Bottle22.48USD bottle
Lisinopril 100% powder21.6USD g
Zestril 40 mg tablet2.53USD tablet
Zestril 30 mg tablet2.41USD tablet
Prinivil 40 mg tablet2.23USD tablet
Zestoretic 20-25 mg tablet2.01USD tablet
Zestoretic 20-12.5 mg tablet2.0USD tablet
Prinzide 20-25 mg tablet1.98USD tablet
Zestoretic 10-12.5 mg tablet1.89USD tablet
Zestoretic 10-12.5 tablet1.75USD tablet
Lisinopril 30 mg tablet1.53USD tablet
Lisinopril 40 mg tablet1.44USD tablet
Prinzide 20-12.5 mg tablet1.38USD tablet
Prinzide 10-12.5 mg tablet1.37USD tablet
Zestril 20 mg tablet1.37USD tablet
Zestril 10 mg tablet1.33USD tablet
Zestoretic 20-25 tablet1.28USD tablet
Zestril 5 mg tablet1.28USD tablet
Zestoretic 20-12.5 tablet1.26USD tablet
Lisinopril 20 mg tablet1.09USD tablet
Prinivil 20 mg tablet1.05USD tablet
Zestril 2.5 mg tablet1.04USD tablet
Lisinopril 10 mg tablet1.01USD tablet
Prinivil 10 mg tablet1.01USD tablet
Lisinopril 5 mg tablet0.99USD tablet
Prinivil 5 mg tablet0.96USD tablet
Apo-Lisinopril 20 mg Tablet0.71USD tablet
Co Lisinopril 20 mg Tablet0.71USD tablet
Mylan-Lisinopril 20 mg Tablet0.71USD tablet
Novo-Lisinopril (Type P) 20 mg Tablet0.71USD tablet
Novo-Lisinopril (Type Z) 20 mg Tablet0.71USD tablet
Pms-Lisinopril 20 mg Tablet0.71USD tablet
Ran-Lisinopril 20 mg Tablet0.71USD tablet
Ratio-Lisinopril P 20 mg Tablet0.71USD tablet
Ratio-Lisinopril Z 20 mg Tablet0.71USD tablet
Sandoz Lisinopril 20 mg Tablet0.71USD tablet
Lisinopril 2.5 mg tablet0.65USD tablet
Apo-Lisinopril 10 mg Tablet0.59USD tablet
Co Lisinopril 10 mg Tablet0.59USD tablet
Mylan-Lisinopril 10 mg Tablet0.59USD tablet
Novo-Lisinopril (Type P) 10 mg Tablet0.59USD tablet
Novo-Lisinopril (Type Z) 10 mg Tablet0.59USD tablet
Pms-Lisinopril 10 mg Tablet0.59USD tablet
Ran-Lisinopril 10 mg Tablet0.59USD tablet
Ratio-Lisinopril P 10 mg Tablet0.59USD tablet
Ratio-Lisinopril Z 10 mg Tablet0.59USD tablet
Sandoz Lisinopril 10 mg Tablet0.59USD tablet
Apo-Lisinopril 5 mg Tablet0.49USD tablet
Co Lisinopril 5 mg Tablet0.49USD tablet
Mylan-Lisinopril 5 mg Tablet0.49USD tablet
Novo-Lisinopril (Type P) 5 mg Tablet0.49USD tablet
Novo-Lisinopril (Type Z) 5 mg Tablet0.49USD tablet
Pms-Lisinopril 5 mg Tablet0.49USD tablet
Ran-Lisinopril 5 mg Tablet0.49USD tablet
Ratio-Lisinopril P 5 mg Tablet0.49USD tablet
Ratio-Lisinopril Z 5 mg Tablet0.49USD tablet
Sandoz Lisinopril 5 mg Tablet0.49USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubility9.7E+004 mg/LMERCK INDEX (1996)
logP-1.01MERCK INDEX (1996); pH 7
pKa2.5 (at 25 °C)MERCK INDEX (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.216 mg/mLALOGPS
logP-1.2ALOGPS
logP-3.1ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)3.17ChemAxon
pKa (Strongest Basic)10.21ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area132.96 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity107.37 m3·mol-1ChemAxon
Polarizability43.5 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraMS/MS1D NMR2D NMR
References
Synthesis Reference

Vincenzo Cannata, Valeriano Merli, Stefano Saguatti, “Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril.” U.S. Patent US6166217, issued September, 1972.

US6166217
General Reference
  1. Abdelmalek MF, Douglas DD: Lisinopril-induced isolated visceral angioedema: review of ACE-inhibitor-induced small bowel angioedema. Dig Dis Sci. 1997 Apr;42(4):847-50. Pubmed
  2. Hasslacher C: Influence of the ACE inhibitor lisinopril on blood pressure, metabolism, and renal function parameter in hypertensive type II diabetic patients: a postmarketing surveillance study. J Diabetes Complications. 1996 May-Jun;10(3):136-8. Pubmed
  3. Nielsen SE, Sugaya T, Tarnow L, Lajer M, Schjoedt KJ, Astrup AS, Baba T, Parving HH, Rossing P: Tubular and glomerular injury in diabetes and the impact of ACE inhibition. Diabetes Care. 2009 Sep;32(9):1684-8. Epub 2009 Jun 5. Pubmed
  4. Patchett AA, Harris E, Tristram EW, Wyvratt MJ, Wu MT, Taub D, Peterson ER, Ikeler TJ, ten Broeke J, Payne LG, Ondeyka DL, Thorsett ED, Greenlee WJ, Lohr NS, Hoffsommer RD, Joshua H, Ruyle WV, Rothrock JW, Aster SD, Maycock AL, Robinson FM, Hirschmann R, Sweet CS, Ulm EH, Gross DM, Vassil TC, Stone CA: A new class of angiotensin-converting enzyme inhibitors. Nature. 1980 Nov 20;288(5788):280-3. Pubmed
External Links
ATC CodesC09AA03
AHFS Codes
  • 24:32.04
PDB Entries
FDA labelDownload (267 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AmilorideIncreased risk of hyperkalemia
Azilsartan medoxomilPharmacodynamic synergism: dual blockade of renin-angiotensin system. Increases risks of hypotension, hyperkalemia, renal impairment.
DrospirenoneIncreased risk of hyperkalemia
LithiumThe ACE inhibitor increases serum levels of lithium
PotassiumIncreased risk of hyperkalemia
SpironolactoneIncreased risk of hyperkalemia
TizanidineTizanidine increases the risk of hypotension with the ACE inhibitor
TobramycinIncreased risk of nephrotoxicity
TreprostinilAdditive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
TriamtereneIncreased risk of hyperkalemia
Food Interactions
  • Herbs that may attenuate the antihypertensive effect of lisinopril include: bayberry, blue cohash, cayenne, ephedra, ginger, ginseng (American), kola and licorice.
  • High salt intake may attenuate the antihypertensive effect of lisinopril.
  • Lisinopril decreases the excretion of potassium. Salt substitutes containing potassium increase the risk of hyperkalemia.
  • Take without regard to meals.

Targets

1. Angiotensin-converting enzyme

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Angiotensin-converting enzyme P12821 Details

References:

  1. Andujar-Sanchez M, Jara-Perez V, Camara-Artigas A: Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett. 2007 Jul 24;581(18):3449-54. Epub 2007 Jun 27. Pubmed
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  3. Piepho RW: Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7. Pubmed
  4. Song JC, White CM: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. Pubmed
  5. Tellez-Sanz R, Garcia-Fuentes L, Baron C: Calorimetric analysis of lisinopril binding to angiotensin I-converting enzyme. FEBS Lett. 1998 Feb 13;423(1):75-80. Pubmed

2. Angiotensin-converting enzyme 2

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
Angiotensin-converting enzyme 2 Q9BYF1 Details

References:

  1. Parish RC, Miller LJ: Adverse effects of angiotensin converting enzyme (ACE) inhibitors. An update. Drug Saf. 1992 Jan-Feb;7(1):14-31. Pubmed
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  3. Piepho RW: Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7. Pubmed
  4. Song JC, White CM: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. Pubmed

2. Solute carrier family 15 member 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Solute carrier family 15 member 1 P46059 Details

References:

  1. Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on January 08, 2014 09:42