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Identification
NameLisinopril
Accession NumberDB00722  (APRD00560)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionLisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
Structure
Thumb
Synonyms
(S)-1-(N(2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline
[N2-[(S)-1-CARBOXY-3-phenylpropyl]-L-lysyl-L-proline
Lisinopril
Lisinopril anhydrous
Lisinoprilum
External Identifiers
  • L 154826
  • MK 521
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Lisinopriltablet5 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Act Lisinopriltablet10 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Act Lisinopriltablet20 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Auro-lisinopriltablet10 mgoralAuro Pharma Inc2013-02-12Not applicableCanada
Auro-lisinopriltablet20 mgoralAuro Pharma Inc2013-02-12Not applicableCanada
Auro-lisinopriltablet5 mgoralAuro Pharma Inc2013-02-12Not applicableCanada
Dom-lisinopriltablet10 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Dom-lisinopriltablet20 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Dom-lisinopriltablet5 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Ipg-lisinopriltablet20 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-lisinopriltablet5 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-lisinopriltablet10 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Jamp-lisinopriltablet5 mgoralJamp Pharma Corporation2011-02-04Not applicableCanada
Jamp-lisinopriltablet10 mgoralJamp Pharma Corporation2011-02-04Not applicableCanada
Jamp-lisinopriltablet20 mgoralJamp Pharma Corporation2011-02-04Not applicableCanada
Lisinopriltablet5 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Lisinopriltablet5 mgoralSorres Pharma Inc2009-06-222014-06-20Canada
Lisinopriltablet10 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lisinopriltablet20 mgoralMeliapharm Inc2008-03-122014-06-25Canada
Lisinopriltablet10 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Lisinopriltablet10 mgoralSorres Pharma Inc2009-06-222014-06-20Canada
Lisinopriltablet20 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lisinopriltablet20 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Lisinopriltablet5 mgoralMeliapharm Inc2008-03-122014-06-25Canada
Lisinopriltablet20 mgoralSorres Pharma Inc2009-06-222014-06-20Canada
Lisinopriltablet40 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Lisinopriltablet5 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lisinopriltablet10 mgoralMeliapharm Inc2008-03-122014-06-25Canada
Lisinopril Tabletstablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Lisinopril Tabletstablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Lisinopril Tabletstablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Lisinopril Tablets USPtablet10 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Lisinopril Tablets USPtablet20 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Lisinopril Tablets USPtablet5 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Mar-lisinopriltablet20 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-lisinopriltablet5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-lisinopriltablet10 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mint-lisinopriltablet5 mgoralMint Pharmaceuticals Inc2008-10-282012-08-02Canada
Mint-lisinopriltablet10 mgoralMint Pharmaceuticals Inc2008-10-282012-08-02Canada
Mint-lisinopriltablet20 mgoralMint Pharmaceuticals Inc2008-10-282012-08-02Canada
Mylan-lisinopriltablet5 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Mylan-lisinopriltablet10 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Mylan-lisinopriltablet20 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Nu-lisinopriltablet10 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet10 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet20 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet20 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet40 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet40 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet5 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet5 mgoralNu Pharm IncNot applicableNot applicableCanada
PMS-lisinopriltablet5 mgoralPharmascience Inc2007-10-17Not applicableCanada
PMS-lisinopriltablet10 mgoralPharmascience Inc2007-10-17Not applicableCanada
PMS-lisinopriltablet20 mgoralPharmascience Inc2007-10-17Not applicableCanada
Priniviltablet5 mg/1oralMerck Sharp & Dohme Corp.1987-12-29Not applicableUs
Priniviltablet10 mg/1oralMerck Sharp & Dohme Corp.1987-12-29Not applicableUs
Priniviltablet5 mgoralMerck Canada Inc1990-12-31Not applicableCanada
Priniviltablet20 mg/1oralMerck Sharp & Dohme Corp.1987-12-29Not applicableUs
Priniviltablet10 mgoralMerck Canada Inc1990-12-31Not applicableCanada
Priniviltablet2.5 mgoralMerck Canada Inc2000-01-052005-06-23Canada
Priniviltablet20 mgoralMerck Canada Inc1990-12-31Not applicableCanada
Pro-lisinopril - 10tablet10 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Pro-lisinopril - 20tablet20 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Pro-lisinopril - 5tablet5 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Ran-lisinopriltablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.2007-10-17Not applicableCanada
Ran-lisinopriltablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.2007-10-17Not applicableCanada
Ran-lisinopriltablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.2007-10-17Not applicableCanada
Ratio-lisinopril Ptablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ptablet20 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ptablet5 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ztablet20 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ztablet5 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ztablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Riva-lisinopriltablet20 mgoralLaboratoire Riva Inc2007-10-26Not applicableCanada
Riva-lisinopriltablet5 mgoralLaboratoire Riva Inc2007-10-26Not applicableCanada
Riva-lisinopriltablet10 mgoralLaboratoire Riva Inc2007-10-26Not applicableCanada
Sandoz Lisinopriltablet5 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Sandoz Lisinopriltablet10 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Sandoz Lisinopriltablet20 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Teva-lisinopril (type P)tablet10 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type P)tablet20 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type P)tablet5 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type Z)tablet20 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type Z)tablet5 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type Z)tablet10 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Zestriltablet40 mg/1oralAstra Zeneca Pharmaceuticals Lp2010-03-26Not applicableUs
Zestriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2011-11-09Not applicableUs
Zestriltablet10 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet10 mg/1oralAstra Zeneca Pharmaceuticals Lp2009-08-28Not applicableUs
Zestriltablet2.5 mg/1oralAstra Zeneca Pharmaceuticals Lp2011-09-02Not applicableUs
Zestriltablet20 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet20 mg/1oralAstra Zeneca Pharmaceuticals Lp2009-05-13Not applicableUs
Zestriltablet2.5 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet30 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet30 mg/1oralAstra Zeneca Pharmaceuticals Lp2010-09-22Not applicableUs
Zestriltablet5 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet5 mg/1oralAstra Zeneca Pharmaceuticals Lp2009-11-11Not applicableUs
Zestriltablet40 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestril Tab 10mgtablet10 mgoralAstrazeneca Canada Inc1994-12-31Not applicableCanada
Zestril Tab 20mgtablet20 mgoralAstrazeneca Canada Inc1994-12-31Not applicableCanada
Zestril Tab 5mgtablet5 mgoralAstrazeneca Canada Inc1994-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lisinopril Tablet (type P) - 10mgtablet10 mgoralApotex Inc1996-10-302001-08-02Canada
Apo-lisinopril Tablet (type P) - 20mgtablet20 mgoralApotex Inc1996-10-302001-08-02Canada
Apo-lisinopril Tablet (type P) - 40mgtablet40 mgoralApotex Inc1996-12-302001-08-02Canada
Apo-lisinopril Tablet (type P) - 5mgtablet5 mgoralApotex Inc1996-10-302001-08-02Canada
Apo-lisinopril Tablet 10 mgtablet10 mgoralApotex Inc1996-10-30Not applicableCanada
Apo-lisinopril Tablet 20 mgtablet20 mgoralApotex Inc1996-10-30Not applicableCanada
Apo-lisinopril Tablet 40 mgtablet40 mgoralApotex Inc1996-10-30Not applicableCanada
Apo-lisinopril Tablet 5 mgtablet5 mgoralApotex Inc1996-10-30Not applicableCanada
Lisinopriltablet30 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralLegacy Pharmaceutical Packaging2010-10-01Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet40 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralMajor Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet20 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet20 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralSTAT Rx USA LLC2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet30 mg/1oralEon Labs, Inc.2015-08-19Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-02-28Not applicableUs
Lisinopriltablet10 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet40 mg/1oralSt Marys Medical Park Pharmacy2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralAidarex Pharmaceuticals LLC2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralPreferred Pharmaceuticals Inc.2016-04-12Not applicableUs
Lisinopriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralREMEDYREPACK INC.2011-04-20Not applicableUs
Lisinopriltablet20 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet10 mg/301oralNorthwind Pharmaceuticals2014-05-20Not applicableUs
Lisinopriltablet40 mg/1oralReady Meds2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Lisinopriltablet30 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet40 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Lisinopriltablet10 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet40 mg/1oralPhysicians Total Care, Inc.2004-08-25Not applicableUs
Lisinopriltablet20 mg/1oralContract Pharmacy Services Pa2002-08-02Not applicableUs
Lisinopriltablet5 mg/1oralInternational Labs, Inc.2012-02-20Not applicableUs
Lisinopriltablet30 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralAmerican Health Packaging2013-12-23Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralMc Kesson Contract Packaging2011-09-16Not applicableUs
Lisinopriltablet10 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralWest Ward Pharmaceuticals Corp2013-02-13Not applicableUs
Lisinopriltablet40 mg/1oralBlenheim Pharmacal, Inc.2010-05-20Not applicableUs
Lisinopriltablet40 mg/1oralAmerican Health Packaging2005-09-222015-12-05Us
Lisinopriltablet2.5 mg/1oralHikma Pharmaceutical2013-08-22Not applicableUs
Lisinopriltablet10 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralRebel Distributors Corp2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralApotex Corp.2008-01-22Not applicableUs
Lisinopriltablet5 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2015-10-08Not applicableUs
Lisinopriltablet2.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet10 mg/1oralLake Erie Medical Quality Care Products LLC2012-03-27Not applicableUs
Lisinopriltablet10 mg/1oralProficient Rx LP2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet40 mg/1oralbryant ranch prepack2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Lisinopriltablet20 mg/1oralTYA Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Lisinopriltablet2.5 mg/1oralREMEDYREPACK INC.2011-07-13Not applicableUs
Lisinopriltablet10 mg/1oralMylan Institutional Inc.2002-08-01Not applicableUs
Lisinopriltablet30 mg/1oralRanbaxy Pharmaceuticals Inc.2006-05-15Not applicableUs
Lisinopriltablet2.5 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs
Lisinopriltablet20 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet2.5 mg/1oralAidarex Pharmaceuticals LLC2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralMed Vantx, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralInternational Laboratories, Inc.2015-05-12Not applicableUs
Lisinopriltablet20 mg/1oralBlue Point Laboratories2015-07-06Not applicableUs
Lisinopriltablet5 mg/1oralPhysicians Total Care, Inc.2008-04-10Not applicableUs
Lisinopriltablet20 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals Inc.2015-10-29Not applicableUs
Lisinopriltablet2.5 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-02Not applicableUs
Lisinopriltablet2.5 mg/1oralMc Kesson Contract Packaging2011-09-01Not applicableUs
Lisinopriltablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2005-11-17Not applicableUs
Lisinopriltablet20 mg/1oralMajor Pharmaceuticals2015-06-15Not applicableUs
Lisinopriltablet40 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet5 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralKAISER FOUNDATION HOSPITALS2008-11-03Not applicableUs
Lisinopriltablet10 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet10 mg/1oralWest Ward Pharmaceuticals Corp2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralApotex Corp.2008-02-18Not applicableUs
Lisinopriltablet5 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2011-09-29Not applicableUs
Lisinopriltablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lisinopriltablet10 mg/1oralRx Change Co.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2010-09-16Not applicableUs
Lisinopriltablet5 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralProficient Rx LP2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet5 mg/1oralReady Meds2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralREMEDYREPACK INC.2013-05-14Not applicableUs
Lisinopriltablet5 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet5 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet10 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet10 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralCarilion Materials Management2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2012-08-27Not applicableUs
Lisinopriltablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet40 mg/1oralPreferred Pharmaceuticals, Inc2012-04-05Not applicableUs
Lisinopriltablet2.5 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2015-06-09Not applicableUs
Lisinopriltablet2.5 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet2.5 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralBlenheim Pharmacal, Inc.2015-02-19Not applicableUs
Lisinopriltablet2.5 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet2.5 mg/1oralEon Labs, Inc.2015-12-21Not applicableUs
Lisinopriltablet2.5 mg/1oralRebel Distributors Corp2008-02-01Not applicableUs
Lisinopriltablet40 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralSt Marys Medical Park Pharmacy2013-05-16Not applicableUs
Lisinopriltablet40 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet20 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralPd Rx Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet30 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Lisinopriltablet2.5 mg/1oralBlue Point Laboratories2014-07-31Not applicableUs
Lisinopriltablet2.5 mg/1oralPhysicians Total Care, Inc.2009-02-16Not applicableUs
Lisinopriltablet2.5 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralLegacy Pharmaceutical Packaging, Llc2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet, film coated20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralMajor Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet30 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet40 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralSTAT Rx USA LLC2007-04-19Not applicableUs
Lisinopriltablet30 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet40 mg/1oralEon Labs, Inc.2015-06-09Not applicableUs
Lisinopriltablet2.5 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet20 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2015-03-25Not applicableUs
Lisinopriltablet5 mg/1oralAidarex Pharmaceuticals LLC2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals Inc.2016-04-12Not applicableUs
Lisinopriltablet2.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralREMEDYREPACK INC.2011-04-14Not applicableUs
Lisinopriltablet2.5 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet10 1/1oralNorthwind Pharmaceuticals, LLC2014-11-17Not applicableUs
Lisinopriltablet2.5 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Lisinopriltablet2.5 mg/1oralbryant ranch prepack2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Lisinopriltablet20 mg/1oralTYA Pharmaceuticals2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet20 mg/1oralRed Pharm Drug Inc.2002-07-02Not applicableUs
Lisinopriltablet40 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet5 mg/1oralLiberty Pharmaceuticals, Inc.2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralAmerican Health Packaging2013-12-23Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2005-09-22Not applicableUs
Lisinopriltablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals, Inc.2013-12-03Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2012-10-05Not applicableUs
Lisinopriltablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralWest Ward Pharmaceuticals Corp2013-02-13Not applicableUs
Lisinopriltablet5 mg/1oralBlenheim Pharmacal, Inc.2014-02-28Not applicableUs
Lisinopriltablet30 mg/1oralAmerican Health Packaging2014-12-152015-12-29Us
Lisinopriltablet5 mg/1oralHikma Pharmaceutical2013-08-22Not applicableUs
Lisinopriltablet20 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralRebel Distributors Corp2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet30 mg/1oralAmerican Health Packaging2015-10-01Not applicableUs
Lisinopriltablet10 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet2.5 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralMedsource Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-07-19Not applicableUs
Lisinopriltablet20 mg/1oralProficient Rx LP2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet10 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet30 mg/1oralREMEDYREPACK INC.2011-07-19Not applicableUs
Lisinopriltablet20 mg/1oralMylan Institutional Inc.2002-08-01Not applicableUs
Lisinopriltablet5 mg/1oralbryant ranch prepack2005-11-17Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-03-20Not applicableUs
Lisinopriltablet40 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet10 mg/1oralContract Pharmacy Services Pa2010-08-12Not applicableUs
Lisinopriltablet10 mg/1oralInternational Laboratories, Inc.2015-05-12Not applicableUs
Lisinopriltablet30 mg/1oralBlue Point Laboratories2015-07-06Not applicableUs
Lisinopriltablet30 mg/1oralPhysicians Total Care, Inc.2007-04-12Not applicableUs
Lisinopriltablet30 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals Inc.2015-10-28Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2012-10-05Not applicableUs
Lisinopriltablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralMc Kesson Contract Packaging2011-09-07Not applicableUs
Lisinopriltablet40 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralMajor Pharmaceuticals2015-06-15Not applicableUs
Lisinopriltablet5 mg/1oralAmerican Health Packaging2005-09-222015-12-29Us
Lisinopriltablet10 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralKAISER FOUNDATION HOSPITALS2008-11-03Not applicableUs
Lisinopriltablet20 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet20 mg/1oralWest Ward Pharmaceuticals Corp2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralApotex Corp.2008-04-17Not applicableUs
Lisinopriltablet10 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2013-12-23Not applicableUs
Lisinopriltablet20 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lisinopriltablet20 mg/1oralRx Change Co.2014-11-12Not applicableUs
Lisinopriltablet40 mg/1oralAidarex Pharmaceuticals LLC2006-01-13Not applicableUs
Lisinopriltablet30 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2010-11-10Not applicableUs
Lisinopriltablet30 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralProficient Rx LP2011-11-01Not applicableUs
Lisinopriltablet5 mg/1oralNorthwind Pharmaceuticals, LLC2014-07-30Not applicableUs
Lisinopriltablet10 mg/1oralReady Meds2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-05-16Not applicableUs
Lisinopriltablet10 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Lisinopriltablet20 mg/1oralBlue Point Laboratories2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet20 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralDispensing Solutions, Inc.2005-11-17Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2012-08-27Not applicableUs
Lisinopriltablet, film coated2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals, Inc2012-04-05Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralMajor Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet5 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralBlenheim Pharmacal, Inc.2015-02-19Not applicableUs
Lisinopriltablet5 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet10 mg/1oralEon Labs, Inc.2015-05-21Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-09-19Not applicableUs
Lisinopriltablet2.5 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet10 mg/1oralSt Marys Medical Park Pharmacy2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet20 mg/1oralNorthwind Pharmaceuticals, LLC2014-11-21Not applicableUs
Lisinopriltablet5 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2014-04-04Not applicableUs
Lisinopriltablet20 mg/1oralMed Vantx, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lisinopriltablet30 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet10 mg/1oralPhysicians Total Care, Inc.2005-07-25Not applicableUs
Lisinopriltablet5 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals Inc.2015-08-28Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet, film coated30 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Lisinopriltablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2005-11-17Not applicableUs
Lisinopriltablet5 mg/1oralMajor Pharmaceuticals2015-06-15Not applicableUs
Lisinopriltablet20 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet40 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet30 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet40 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet5 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet30 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2015-07-22Not applicableUs
Lisinopriltablet30 mg/1oralAidarex Pharmaceuticals LLC2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralAphena Pharma Solutions Tennessee, Llc2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2011-03-29Not applicableUs
Lisinopriltablet40 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralLake Erie Medical Quality Care Products LLC2012-03-27Not applicableUs
Lisinopriltablet40 mg/1oralProficient Rx LP2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Lisinopriltablet5 mg/1oralTYA Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet10 mg/1oralRed Pharm Drug Inc.2005-11-17Not applicableUs
Lisinopriltablet30 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet2.5 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralAmerican Health Packaging2013-12-23Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2012-08-27Not applicableUs
Lisinopriltablet2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet5 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2005-09-22Not applicableUs
Lisinopriltablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2015-05-21Not applicableUs
Lisinopriltablet40 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet5 mg/1oralWest Ward Pharmaceuticals Corp2013-02-13Not applicableUs
Lisinopriltablet2.5 mg/1oralBlenheim Pharmacal, Inc.2014-01-14Not applicableUs
Lisinopriltablet10 mg/1oralHikma Pharmaceutical2013-08-22Not applicableUs
Lisinopriltablet30 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralRebel Distributors Corp2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralSt Marys Medical Park Pharmacy2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet5 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-02Not applicableUs
Lisinopriltablet10 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Lisinopriltablet20 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2013-12-23Not applicableUs
Lisinopriltablet5 mg/1oralDIRECT RX2015-01-01Not applicableUs
Lisinopriltablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not applicableUs
Lisinopriltablet20 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2011-05-19Not applicableUs
Lisinopriltablet40 mg/1oralMylan Institutional Inc.2002-08-01Not applicableUs
Lisinopriltablet10 mg/1oralbryant ranch prepack2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2012-12-31Not applicableUs
Lisinopriltablet30 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet10 mg/1oralContract Pharmacy Services Pa2002-07-02Not applicableUs
Lisinopriltablet5 mg/1oralInternational Laboratories, Inc.2015-05-12Not applicableUs
Lisinopriltablet40 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals, Inc.2013-05-02Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2012-10-05Not applicableUs
Lisinopriltablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralMc Kesson Contract Packaging2011-09-08Not applicableUs
Lisinopriltablet2.5 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralBlenheim Pharmacal, Inc.2009-12-16Not applicableUs
Lisinopriltablet10 mg/1oralAmerican Health Packaging2005-09-222015-12-29Us
Lisinopriltablet20 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralKAISER FOUNDATION HOSPITALS2008-11-03Not applicableUs
Lisinopriltablet30 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet40 mg/1oralWest Ward Pharmaceuticals Corp2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralApotex Corp.2008-06-25Not applicableUs
Lisinopriltablet10 mg/1oralSTAT Rx USA LLC2005-11-17Not applicableUs
Lisinopriltablet10 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet20 mg/1oralEon Labs, Inc.2015-05-23Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-05-20Not applicableUs
Lisinopriltablet5 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet30 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Lisinopriltablet20 mg/1oralAidarex Pharmaceuticals LLC2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2010-11-15Not applicableUs
Lisinopriltablet10 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet40 mg/1oralNorthwind Pharmaceuticals, LLC2015-03-10Not applicableUs
Lisinopriltablet20 mg/1oralReady Meds2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-06-24Not applicableUs
Lisinopriltablet20 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet2.5 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Lisinopriltablet40 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet2.5 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet40 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralKeltman Pharmaceuticals Inc.2010-12-10Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals, Inc2012-04-05Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralMajor Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet10 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet10 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralREMEDYREPACK INC.2011-06-21Not applicableUs
Lisinopriltablet5 mg/1oralMylan Institutional Inc.2002-08-01Not applicableUs
Lisinopriltablet40 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-02-26Not applicableUs
Lisinopriltablet10 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralH.J. Harkins Company, Inc.2005-11-17Not applicableUs
Lisinopriltablet40 mg/1oralMed Vantx, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralInternational Laboratories, Inc.2015-05-12Not applicableUs
Lisinopriltablet10 mg/1oralBlue Point Laboratories2015-07-06Not applicableUs
Lisinopriltablet20 mg/1oralPhysicians Total Care, Inc.2007-09-17Not applicableUs
Lisinopriltablet10 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralPreferred Pharmaceuticals Inc.2015-08-28Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet, film coated40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralLife Line Home Care Services, Inc.2010-08-12Not applicableUs
Lisinopriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralMajor Pharmaceuticals2015-06-15Not applicableUs
Lisinopriltablet30 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet2.5 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralKAISER FOUNDATION HOSPITALS2013-08-05Not applicableUs
Lisinopriltablet5 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet5 mg/1oralWest Ward Pharmaceuticals Corp2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralApotex Corp.2008-06-26Not applicableUs
Lisinopriltablet2.5 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet40 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2015-12-23Not applicableUs
Lisinopriltablet5 mg/1oralRx Change Co.2014-11-18Not applicableUs
Lisinopriltablet2.5 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet10 mg/1oralSafecor Health, LLC2014-10-01Not applicableUs
Lisinopriltablet30 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not applicableUs
Lisinopriltablet20 mg/1oralProficient Rx LP2006-01-13Not applicableUs
Lisinopriltablet30 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralREMEDYREPACK INC.2013-05-13Not applicableUs
Lisinopriltablet2.5 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet20 mg/1oralRed Pharm Drug Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet5 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralAmerican Health Packaging2014-06-02Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2012-08-27Not applicableUs
Lisinopriltablet30 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet5 mg/1oralPreferred Pharmaceuticals Inc.2015-08-20Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2005-09-22Not applicableUs
Lisinopriltablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2015-05-23Not applicableUs
Lisinopriltablet30 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet2.5 mg/1oralWest Ward Pharmaceuticals Corp2013-02-132016-02-18Us
Lisinopriltablet5 mg/1oralBlenheim Pharmacal, Inc.2015-02-19Not applicableUs
Lisinopriltablet20 mg/1oralHikma Pharmaceutical2013-08-22Not applicableUs
Lisinopriltablet40 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralRebel Distributors Corp2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Lisinopriltablet30 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet10 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralBlenheim Pharmacal, Inc.2009-12-16Not applicableUs
Lisinopriltablet20 mg/1oralAmerican Health Packaging2005-09-222015-12-29Us
Lisinopriltablet40 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralAccord Healthcare Inc.2013-07-30Not applicableUs
Lisinopriltablet2.5 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet30 mg/1oralApotex Corp.2002-10-09Not applicableUs
Lisinopriltablet40 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2013-12-23Not applicableUs
Lisinopriltablet40 mg/1oralDIRECT RX2015-01-01Not applicableUs
Lisinopriltablet40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not applicableUs
Lisinopriltablet30 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2011-09-29Not applicableUs
Lisinopriltablet2.5 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet20 mg/1oralbryant ranch prepack2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-07-05Not applicableUs
Lisinopriltablet10 mg/1oralTYA Pharmaceuticals2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet20 mg/1oralContract Pharmacy Services Pa2010-08-12Not applicableUs
Lisinopriltablet40 mg/1oralInternational Labs, Inc.2012-02-20Not applicableUs
Lisinopriltablet5 mg/1oralAmerican Health Packaging2013-12-23Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet5 mg/1oralPreferred Pharmaceuticals, Inc.2013-12-03Not applicableUs
Lisinopriltablet2.5 mg/1oralCardinal Health2012-10-05Not applicableUs
Lisinopriltablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralMc Kesson Contract Packaging2011-09-09Not applicableUs
Lisinopriltablet5 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopril 10mgtablet10 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Lisinopril 2.5mgtablet2.5 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Lisinopril 20mgtablet20 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Lisinopril 40mgtablet40 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Lisinopril 5mgtablet5 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AcebitorGlaxoSmithKline
AceminAstraZeneca
AcerbonAstraZeneca
Acinoprilsanofi-aventis
BellisinRanbaxy
BioprilBiochem
DaprilMedochemie
FibsolSigma
FisoprilSanofi-Aventis
HiprilMicro Labs
LinoprilKlinger (Brazil)
LisiprilHexal (Czech Republic), Orion (Finland)
NopertenDexa (Indonesia)
PresitenMagnachem
RanolipRanbaxy
RanoprilRanbaxy
RantexBiotech
SinoprenRanbaxy
SinoprilEczacibasi (Russia)
TensoprilMerck
Brand mixtures
NameLabellerIngredients
Apo-lisinopril/hctzApotex Inc
Ava-lisinopril HctAvanstra Inc
Lisinopril and HctzNorthwind Pharmaceuticals, LLC
Lisinopril and HydrochlorothiazideIVAX Pharmaceuticals, Inc.
Lisinopril and HydrochlorthiazideREMEDYREPACK INC.
Lisinopril With HydrochlorothiazideWest Ward Pharmaceuticals Corp
Lisinopril/hctz (type Z)Sanis Health Inc
Lisnopril/hctz (type P)Sanis Health Inc
Lytensopril-90Physician Therapeutics Llc
Mylan-lisinopril HctzMylan Pharmaceuticals Ulc
Ntp-lisinopril/hctz (type P)Teva Canada Limited
Ntp-lisinopril/hctz (type Z)Teva Canada Limited
Nu-lisinopril/hctzNu Pharm Inc
PrinzideMerck Canada Inc
Sandoz Lisinopril HctSandoz Canada Incorporated
Teva-lisinopril/hctz (type P)Teva Canada Limited
Teva-lisinopril/hctz (type Z)Teva Canada Limited
ZestoreticAstra Zeneca Pharmaceuticals Lp
Zestoretic Tab 10/12.5mgAstrazeneca Canada Inc
Zestoretic Tab 20/12.5mgAstrazeneca Canada Inc
Zestoretic Tab 20/25mgAstrazeneca Canada Inc
SaltsNot Available
Categories
UNIIE7199S1YWR
CAS number83915-83-7
WeightAverage: 405.4879
Monoisotopic: 405.226371117
Chemical FormulaC21H31N3O5
InChI KeyInChIKey=RLAWWYSOJDYHDC-BZSNNMDCSA-N
InChI
InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1
IUPAC Name
(2S)-1-[(2S)-6-amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]pyrrolidine-2-carboxylic acid
SMILES
NCCCC[[email protected]](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[[email protected]]1C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentPeptides
Alternative Parents
Substituents
  • Alpha peptide
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Alpha-amino acid amide
  • L-alpha-amino acid
  • Phenylpropylamine
  • Alpha-amino acid or derivatives
  • N-substituted-alpha-amino acid
  • Alpha-amino acid
  • Pyrrolidine carboxylic acid or derivatives
  • Pyrrolidine carboxylic acid
  • N-acylpyrrolidine
  • Aralkylamine
  • Amino fatty acid
  • Fatty acyl
  • Benzenoid
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Tertiary amine
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Secondary aliphatic amine
  • Carboxylic acid
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
PharmacodynamicsLisinopril is an orally active ACE inhibitor that antagonizes the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may further sustain the effects of lisinopril by causing increased vasodilation and decreased blood pressure.
Mechanism of actionThere are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Lisinopril, one of the few ACE inhibitors that is not a prodrug, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Lisinopril also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors.
Related Articles
AbsorptionApproximately 25%, but widely variable between individuals (6 to 60%) in all doses tested (5-80 mg); absorption is unaffected by food
Volume of distributionNot Available
Protein bindingLisinopril does not appear to be bound to serum proteins other than ACE.
Metabolism

Does not undergo metabolism, excreted unchanged in urine.

Route of eliminationLisinopril does not undergo metabolism and is excreted unchanged entirely in the urine.
Half lifeEffective half life of accumulation following multiple dosing is 12 hours.
Clearance
  • 10 L/h [child weighting 30 kg receiving doses of 0.1 to 0.2 mg/kg]
ToxicitySymptoms of overdose include severe hypotension, electrolyte disturbances, and renal failure. LD50= 2000 mg/kg(orally in rat). Most frequent adverse effects include headache, dizziness, cough, fatigue and diarrhea.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Lisinopril Action PathwayDrug actionSMP00150
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6426
Blood Brain Barrier-0.8815
Caco-2 permeable-0.7605
P-glycoprotein substrateSubstrate0.6515
P-glycoprotein inhibitor INon-inhibitor0.9512
P-glycoprotein inhibitor IINon-inhibitor0.969
Renal organic cation transporterNon-inhibitor0.8574
CYP450 2C9 substrateNon-substrate0.8793
CYP450 2D6 substrateNon-substrate0.7622
CYP450 3A4 substrateNon-substrate0.725
CYP450 1A2 substrateNon-inhibitor0.8999
CYP450 2C9 inhibitorNon-inhibitor0.9708
CYP450 2D6 inhibitorNon-inhibitor0.9653
CYP450 2C19 inhibitorNon-inhibitor0.8266
CYP450 3A4 inhibitorNon-inhibitor0.907
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9821
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9389
BiodegradationNot ready biodegradable0.6844
Rat acute toxicity1.8723 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9641
hERG inhibition (predictor II)Non-inhibitor0.8708
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Actavis elizabeth llc
  • Apotex inc etobicoke site
  • Aurobindo pharma ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lek pharmaceuticals d d
  • Lupin ltd
  • Mylan pharmaceuticals inc
  • Ranbaxy pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Vintage pharmaceuticals llc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Wockhardt ltd
  • Merck research laboratories div merck co inc
  • Astrazeneca uk ltd
Packagers
Dosage forms
FormRouteStrength
Tabletoral40 mg
Tabletoral10 1/1
Tabletoral10 mg/301
Tabletoral2.5 mg/1
Tabletoral30 mg/1
Tabletoral40 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral2.5 mg/1
Tablet, film coatedoral20 mg/1
Tablet, film coatedoral30 mg/1
Tablet, film coatedoral40 mg/1
Tablet, film coatedoral5 mg/1
Tabletoral
Kit
Tabletoral10 mg
Tabletoral10 mg/1
Tabletoral2.5 mg
Tabletoral20 mg/1
Tabletoral20 mg
Tabletoral5 mg/1
Tabletoral5 mg
Prices
Unit descriptionCostUnit
Prinivil 90 20 mg tablet Bottle111.71USD bottle
Prinzide 30 20-12.5 mg tablet Bottle45.99USD bottle
Prinivil 30 2.5 mg tablet Bottle22.48USD bottle
Lisinopril 100% powder21.6USD g
Zestril 40 mg tablet2.53USD tablet
Zestril 30 mg tablet2.41USD tablet
Prinivil 40 mg tablet2.23USD tablet
Zestoretic 20-25 mg tablet2.01USD tablet
Zestoretic 20-12.5 mg tablet2.0USD tablet
Prinzide 20-25 mg tablet1.98USD tablet
Zestoretic 10-12.5 mg tablet1.89USD tablet
Zestoretic 10-12.5 tablet1.75USD tablet
Lisinopril 30 mg tablet1.53USD tablet
Lisinopril 40 mg tablet1.44USD tablet
Prinzide 20-12.5 mg tablet1.38USD tablet
Prinzide 10-12.5 mg tablet1.37USD tablet
Zestril 20 mg tablet1.37USD tablet
Zestril 10 mg tablet1.33USD tablet
Zestoretic 20-25 tablet1.28USD tablet
Zestril 5 mg tablet1.28USD tablet
Zestoretic 20-12.5 tablet1.26USD tablet
Lisinopril 20 mg tablet1.09USD tablet
Prinivil 20 mg tablet1.05USD tablet
Zestril 2.5 mg tablet1.04USD tablet
Lisinopril 10 mg tablet1.01USD tablet
Prinivil 10 mg tablet1.01USD tablet
Lisinopril 5 mg tablet0.99USD tablet
Prinivil 5 mg tablet0.96USD tablet
Apo-Lisinopril 20 mg Tablet0.71USD tablet
Co Lisinopril 20 mg Tablet0.71USD tablet
Mylan-Lisinopril 20 mg Tablet0.71USD tablet
Novo-Lisinopril (Type P) 20 mg Tablet0.71USD tablet
Novo-Lisinopril (Type Z) 20 mg Tablet0.71USD tablet
Pms-Lisinopril 20 mg Tablet0.71USD tablet
Ran-Lisinopril 20 mg Tablet0.71USD tablet
Ratio-Lisinopril P 20 mg Tablet0.71USD tablet
Ratio-Lisinopril Z 20 mg Tablet0.71USD tablet
Sandoz Lisinopril 20 mg Tablet0.71USD tablet
Lisinopril 2.5 mg tablet0.65USD tablet
Apo-Lisinopril 10 mg Tablet0.59USD tablet
Co Lisinopril 10 mg Tablet0.59USD tablet
Mylan-Lisinopril 10 mg Tablet0.59USD tablet
Novo-Lisinopril (Type P) 10 mg Tablet0.59USD tablet
Novo-Lisinopril (Type Z) 10 mg Tablet0.59USD tablet
Pms-Lisinopril 10 mg Tablet0.59USD tablet
Ran-Lisinopril 10 mg Tablet0.59USD tablet
Ratio-Lisinopril P 10 mg Tablet0.59USD tablet
Ratio-Lisinopril Z 10 mg Tablet0.59USD tablet
Sandoz Lisinopril 10 mg Tablet0.59USD tablet
Apo-Lisinopril 5 mg Tablet0.49USD tablet
Co Lisinopril 5 mg Tablet0.49USD tablet
Mylan-Lisinopril 5 mg Tablet0.49USD tablet
Novo-Lisinopril (Type P) 5 mg Tablet0.49USD tablet
Novo-Lisinopril (Type Z) 5 mg Tablet0.49USD tablet
Pms-Lisinopril 5 mg Tablet0.49USD tablet
Ran-Lisinopril 5 mg Tablet0.49USD tablet
Ratio-Lisinopril P 5 mg Tablet0.49USD tablet
Ratio-Lisinopril Z 5 mg Tablet0.49USD tablet
Sandoz Lisinopril 5 mg Tablet0.49USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubility9.7E+004 mg/LMERCK INDEX (1996)
logP-1.01MERCK INDEX (1996); pH 7
pKa2.5 (at 25 °C)MERCK INDEX (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.216 mg/mLALOGPS
logP-1.2ALOGPS
logP-3.1ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)3.17ChemAxon
pKa (Strongest Basic)10.21ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area132.96 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity107.37 m3·mol-1ChemAxon
Polarizability43.5 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0a4r-0194100000-d9a47a283478b88bb101View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-9040000000-8d6d4ae6ba18da11e336View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-001i-9000000000-77e20f7eb799eea58ab0View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Vincenzo Cannata, Valeriano Merli, Stefano Saguatti, “Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril.” U.S. Patent US6166217, issued September, 1972.

US6166217
General References
  1. Abdelmalek MF, Douglas DD: Lisinopril-induced isolated visceral angioedema: review of ACE-inhibitor-induced small bowel angioedema. Dig Dis Sci. 1997 Apr;42(4):847-50. [PubMed:9125659 ]
  2. Hasslacher C: Influence of the ACE inhibitor lisinopril on blood pressure, metabolism, and renal function parameter in hypertensive type II diabetic patients: a postmarketing surveillance study. J Diabetes Complications. 1996 May-Jun;10(3):136-8. [PubMed:8807458 ]
  3. Nielsen SE, Sugaya T, Tarnow L, Lajer M, Schjoedt KJ, Astrup AS, Baba T, Parving HH, Rossing P: Tubular and glomerular injury in diabetes and the impact of ACE inhibition. Diabetes Care. 2009 Sep;32(9):1684-8. doi: 10.2337/dc09-0429. Epub 2009 Jun 5. [PubMed:19502542 ]
  4. Patchett AA, Harris E, Tristram EW, Wyvratt MJ, Wu MT, Taub D, Peterson ER, Ikeler TJ, ten Broeke J, Payne LG, Ondeyka DL, Thorsett ED, Greenlee WJ, Lohr NS, Hoffsommer RD, Joshua H, Ruyle WV, Rothrock JW, Aster SD, Maycock AL, Robinson FM, Hirschmann R, Sweet CS, Ulm EH, Gross DM, Vassil TC, Stone CA: A new class of angiotensin-converting enzyme inhibitors. Nature. 1980 Nov 20;288(5788):280-3. [PubMed:6253826 ]
External Links
ATC CodesC09AA03C09BB03C09BA03C10BX07
AHFS Codes
  • 24:32.04
PDB Entries
FDA labelDownload (267 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypotensive activities of Lisinopril.
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Lisinopril.
AcebutololLisinopril may increase the hypotensive activities of Acebutolol.
AceclofenacThe risk or severity of adverse effects can be increased when Lisinopril is combined with Aceclofenac.
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Lisinopril.
AcetazolamideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Acetazolamide.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Acetylsalicylic acid.
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Lisinopril.
AdapaleneThe risk or severity of adverse effects can be increased when Lisinopril is combined with Adapalene.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Lisinopril.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Lisinopril.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Lisinopril.
AlfuzosinAlfuzosin may increase the hypotensive activities of Lisinopril.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Lisinopril.
AliskirenLisinopril may increase the hypotensive activities of Aliskiren.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Lisinopril.
AllopurinolThe risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Lisinopril.
AlogliptinThe risk or severity of adverse effects can be increased when Alogliptin is combined with Lisinopril.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Lisinopril.
AlprenololLisinopril may increase the hypotensive activities of Alprenolol.
AmbrisentanLisinopril may increase the hypotensive activities of Ambrisentan.
AmifostineLisinopril may increase the hypotensive activities of Amifostine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Lisinopril.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Lisinopril.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Lisinopril.
Aminosalicylic AcidAminosalicylic Acid may decrease the antihypertensive activities of Lisinopril.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Lisinopril.
AmlodipineAmlodipine may increase the hypotensive activities of Lisinopril.
AmobarbitalAmobarbital may increase the hypotensive activities of Lisinopril.
Amyl NitriteThe risk or severity of adverse effects can be increased when Lisinopril is combined with Amyl Nitrite.
AntipyrineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Antipyrine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Lisinopril.
ApraclonidineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Apraclonidine.
ApremilastThe risk or severity of adverse effects can be increased when Lisinopril is combined with Apremilast.
AprotininAprotinin may decrease the antihypertensive activities of Lisinopril.
ArdeparinArdeparin may increase the hyperkalemic activities of Lisinopril.
AripiprazoleAripiprazole may increase the hypotensive activities of Lisinopril.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Lisinopril.
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Lisinopril.
AtenololAtenolol may increase the hypotensive activities of Lisinopril.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Lisinopril.
AtorvastatinThe risk or severity of adverse effects can be increased when Atorvastatin is combined with Lisinopril.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Lisinopril.
AzapropazoneThe risk or severity of adverse effects can be increased when Lisinopril is combined with Azapropazone.
AzathioprineLisinopril may increase the myelosuppressive activities of Azathioprine.
AzelastineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Azelastine.
Azilsartan medoxomilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Azilsartan medoxomil.
BalsalazideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Balsalazide.
BarbitalBarbital may increase the hypotensive activities of Lisinopril.
BemiparinBemiparin may increase the hyperkalemic activities of Lisinopril.
BenazeprilBenazepril may increase the hypotensive activities of Lisinopril.
BendroflumethiazideBendroflumethiazide may increase the hypotensive activities of Lisinopril.
BenmoxinBenmoxin may increase the hypotensive activities of Lisinopril.
BenoxaprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Benoxaprofen.
BepridilLisinopril may increase the hypotensive activities of Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Lisinopril.
BetaxololBetaxolol may increase the hypotensive activities of Lisinopril.
BethanidineBethanidine may increase the hypotensive activities of Lisinopril.
BimatoprostLisinopril may increase the hypotensive activities of Bimatoprost.
BisoprololBisoprolol may increase the hypotensive activities of Lisinopril.
BoceprevirThe serum concentration of Lisinopril can be decreased when it is combined with Boceprevir.
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Lisinopril.
BosentanBosentan may increase the hypotensive activities of Lisinopril.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Lisinopril.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Lisinopril.
BretyliumLisinopril may increase the hypotensive activities of Bretylium.
BrimonidineLisinopril may increase the hypotensive activities of Brimonidine.
BrimonidineBrimonidine may increase the antihypertensive activities of Lisinopril.
BromfenacThe risk or severity of adverse effects can be increased when Lisinopril is combined with Bromfenac.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Lisinopril.
BumetanideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Bumetanide.
BupranololLisinopril may increase the hypotensive activities of Bupranolol.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Lisinopril.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Lisinopril.
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Lisinopril.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Lisinopril.
CanagliflozinCanagliflozin may increase the hyperkalemic activities of Lisinopril.
CanagliflozinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Canagliflozin.
CandesartanLisinopril may increase the hypotensive activities of Candesartan.
CandoxatrilCandoxatril may increase the hypotensive activities of Lisinopril.
CaptoprilLisinopril may increase the hypotensive activities of Captopril.
CarbamazepineThe metabolism of Lisinopril can be increased when combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Lisinopril.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Lisinopril.
CaroxazoneCaroxazone may increase the hypotensive activities of Lisinopril.
CarprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Carprofen.
CarteololCarteolol may increase the hypotensive activities of Lisinopril.
CarvedilolLisinopril may increase the hypotensive activities of Carvedilol.
CastanospermineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Castanospermine.
CelecoxibThe risk or severity of adverse effects can be increased when Lisinopril is combined with Celecoxib.
CeliprololLisinopril may increase the hypotensive activities of Celiprolol.
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Lisinopril.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Lisinopril.
CertoparinCertoparin may increase the hyperkalemic activities of Lisinopril.
ChloroquineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Chloroquine.
ChlorothiazideLisinopril may increase the hypotensive activities of Chlorothiazide.
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Lisinopril.
ChlorthalidoneChlorthalidone may increase the hypotensive activities of Lisinopril.
CilazaprilLisinopril may increase the hypotensive activities of Cilazapril.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Lisinopril.
CiprofloxacinLisinopril may increase the arrhythmogenic activities of Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Lisinopril.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Lisinopril.
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Lisinopril.
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Lisinopril.
ClevidipineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Clevidipine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Lisinopril.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Lisinopril.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Lisinopril.
ClonidineClonidine may increase the hypotensive activities of Lisinopril.
ClonixinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Clonixin.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Lisinopril.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Lisinopril.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Lisinopril.
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Lisinopril.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Lisinopril.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Lisinopril.
CryptenamineLisinopril may increase the hypotensive activities of Cryptenamine.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Lisinopril.
CyclophosphamideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Lisinopril.
CyclothiazideCyclothiazide may increase the hypotensive activities of Lisinopril.
D-LimoneneThe risk or severity of adverse effects can be increased when Lisinopril is combined with D-Limonene.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Lisinopril.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Lisinopril.
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Lisinopril.
DalteparinDalteparin may increase the hyperkalemic activities of Lisinopril.
DapagliflozinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Dapagliflozin.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Lisinopril.
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Lisinopril.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Lisinopril.
DebrisoquinLisinopril may increase the hypotensive activities of Debrisoquin.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Lisinopril.
DeserpidineLisinopril may increase the hypotensive activities of Deserpidine.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Lisinopril.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Lisinopril.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Lisinopril.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Lisinopril.
DiazoxideDiazoxide may increase the hypotensive activities of Lisinopril.
DiclofenacThe risk or severity of adverse effects can be increased when Lisinopril is combined with Diclofenac.
DiclofenamideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Diclofenamide.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Lisinopril.
DiflunisalThe risk or severity of adverse effects can be increased when Lisinopril is combined with Diflunisal.
DiflunisalDiflunisal may decrease the antihypertensive activities of Lisinopril.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Lisinopril.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Lisinopril.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Lisinopril.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lisinopril.
DiltiazemDiltiazem may increase the hypotensive activities of Lisinopril.
DinutuximabThe risk or severity of adverse effects can be increased when Lisinopril is combined with Dinutuximab.
DipyridamoleThe risk or severity of adverse effects can be increased when Lisinopril is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Lisinopril.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Lisinopril.
DorzolamideLisinopril may increase the hypotensive activities of Dorzolamide.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Lisinopril.
DoxazosinDoxazosin may increase the hypotensive activities of Lisinopril.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Lisinopril.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Lisinopril.
DrospirenoneLisinopril may increase the hyperkalemic activities of Drospirenone.
DroxicamThe risk or severity of adverse effects can be increased when Lisinopril is combined with Droxicam.
DuloxetineLisinopril may increase the orthostatic hypotensive activities of Duloxetine.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Lisinopril.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Lisinopril.
EfonidipineLisinopril may increase the hypotensive activities of Efonidipine.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Lisinopril.
EmpagliflozinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Empagliflozin.
EnalaprilEnalapril may increase the hypotensive activities of Lisinopril.
EnalaprilatLisinopril may increase the hypotensive activities of Enalaprilat.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Lisinopril.
EnoxaparinEnoxaparin may increase the hyperkalemic activities of Lisinopril.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Lisinopril.
EpirizoleThe risk or severity of adverse effects can be increased when Lisinopril is combined with Epirizole.
EplerenoneEplerenone may increase the hyperkalemic activities of Lisinopril.
EplerenoneThe risk or severity of adverse effects can be increased when Lisinopril is combined with Eplerenone.
EpoprostenolLisinopril may increase the hypotensive activities of Epoprostenol.
EprosartanLisinopril may increase the hypotensive activities of Eprosartan.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Lisinopril.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Lisinopril.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Lisinopril.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Lisinopril.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Lisinopril.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Lisinopril.
EsmololThe risk or severity of adverse effects can be increased when Esmolol is combined with Lisinopril.
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Lisinopril.
EstriolThe serum concentration of Estriol can be increased when it is combined with Lisinopril.
EstroneThe serum concentration of Estrone can be increased when it is combined with Lisinopril.
Etacrynic acidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Etacrynic acid.
EtanerceptThe risk or severity of adverse effects can be increased when Lisinopril is combined with Etanercept.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Lisinopril.
EtodolacThe risk or severity of adverse effects can be increased when Lisinopril is combined with Etodolac.
EtofenamateThe risk or severity of adverse effects can be increased when Lisinopril is combined with Etofenamate.
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Lisinopril.
EtoricoxibThe risk or severity of adverse effects can be increased when Lisinopril is combined with Etoricoxib.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Lisinopril.
Evening primrose oilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Evening primrose oil.
EverolimusThe risk or severity of adverse effects can be increased when Everolimus is combined with Lisinopril.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Lisinopril.
exisulindThe risk or severity of adverse effects can be increased when Lisinopril is combined with exisulind.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Lisinopril.
FelodipineLisinopril may increase the hypotensive activities of Felodipine.
FenbufenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Fenbufen.
FenoldopamLisinopril may increase the hypotensive activities of Fenoldopam.
FenoprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Fenoprofen.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Lisinopril.
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Lisinopril.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Lisinopril.
FloctafenineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Floctafenine.
FlunixinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Flunixin.
FlurbiprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Flurbiprofen.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Lisinopril.
ForasartanThe risk or severity of adverse effects can be increased when Forasartan is combined with Lisinopril.
FosinoprilFosinopril may increase the hypotensive activities of Lisinopril.
FurazolidoneFurazolidone may increase the hypotensive activities of Lisinopril.
FurosemideThe risk or severity of adverse effects can be increased when Furosemide is combined with Lisinopril.
GarlicThe serum concentration of Lisinopril can be decreased when it is combined with Garlic.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Lisinopril.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Lisinopril.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Lisinopril.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Lisinopril.
GuanabenzGuanabenz may increase the hypotensive activities of Lisinopril.
GuanadrelGuanadrel may increase the hypotensive activities of Lisinopril.
GuanethidineLisinopril may increase the hypotensive activities of Guanethidine.
GuanfacineLisinopril may increase the hypotensive activities of Guanfacine.
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Lisinopril.
HeparinHeparin may increase the hyperkalemic activities of Lisinopril.
HexamethoniumLisinopril may increase the hypotensive activities of Hexamethonium.
HexobarbitalHexobarbital may increase the hypotensive activities of Lisinopril.
HMPL-004The risk or severity of adverse effects can be increased when Lisinopril is combined with HMPL-004.
HydracarbazineHydracarbazine may increase the hypotensive activities of Lisinopril.
HydralazineLisinopril may increase the hypotensive activities of Hydralazine.
HydrochlorothiazideLisinopril may increase the hypotensive activities of Hydrochlorothiazide.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Lisinopril.
HydroflumethiazideLisinopril may increase the hypotensive activities of Hydroflumethiazide.
IbuprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Ibuprofen.
IbuproxamThe risk or severity of adverse effects can be increased when Lisinopril is combined with Ibuproxam.
IcatibantIcatibant may decrease the antihypertensive activities of Lisinopril.
IcatibantThe risk or severity of adverse effects can be increased when Lisinopril is combined with Icatibant.
IdelalisibThe serum concentration of Idelalisib can be increased when it is combined with Lisinopril.
IloprostIloprost may increase the hypotensive activities of Lisinopril.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Lisinopril.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Lisinopril.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Lisinopril.
IndapamideLisinopril may increase the hypotensive activities of Indapamide.
IndenololLisinopril may increase the hypotensive activities of Indenolol.
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Lisinopril.
IndomethacinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Indomethacin.
IndoprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Indoprofen.
IndoraminLisinopril may increase the hypotensive activities of Indoramin.
IproclozideIproclozide may increase the hypotensive activities of Lisinopril.
IproniazidIproniazid may increase the hypotensive activities of Lisinopril.
IrbesartanLisinopril may increase the hypotensive activities of Irbesartan.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Lisinopril.
IronThe risk or severity of adverse effects can be increased when Lisinopril is combined with Iron.
Iron DextranThe risk or severity of adverse effects can be increased when Lisinopril is combined with Iron Dextran.
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Lisinopril.
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Lisinopril is combined with Isosorbide Dinitrate.
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Lisinopril is combined with Isosorbide Mononitrate.
IsoxicamThe risk or severity of adverse effects can be increased when Lisinopril is combined with Isoxicam.
IsoxsuprineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Isoxsuprine.
IsradipineIsradipine may increase the hypotensive activities of Lisinopril.
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Lisinopril.
KebuzoneThe risk or severity of adverse effects can be increased when Lisinopril is combined with Kebuzone.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Lisinopril.
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Lisinopril.
KetoprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Ketoprofen.
KetorolacThe risk or severity of adverse effects can be increased when Lisinopril is combined with Ketorolac.
LabetalolLabetalol may increase the hypotensive activities of Lisinopril.
LacidipineLisinopril may increase the hypotensive activities of Lacidipine.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Lisinopril.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Lisinopril.
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Lisinopril.
Lanthanum carbonateThe serum concentration of Lisinopril can be decreased when it is combined with Lanthanum carbonate.
LatanoprostLatanoprost may increase the hypotensive activities of Lisinopril.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Lisinopril.
LeflunomideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Lisinopril.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Lisinopril.
LercanidipineLercanidipine may increase the hypotensive activities of Lisinopril.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Lisinopril.
LevobunololThe risk or severity of adverse effects can be increased when Lisinopril is combined with Levobunolol.
LevodopaLisinopril may increase the orthostatic hypotensive activities of Levodopa.
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Lisinopril.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Lisinopril.
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Lisinopril.
LinagliptinThe risk or severity of adverse effects can be increased when Linagliptin is combined with Lisinopril.
LithiumThe serum concentration of Lithium can be increased when it is combined with Lisinopril.
LofexidineLisinopril may increase the hypotensive activities of Lofexidine.
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Lisinopril.
LornoxicamThe risk or severity of adverse effects can be increased when Lisinopril is combined with Lornoxicam.
LosartanLosartan may increase the hypotensive activities of Lisinopril.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Lisinopril.
LoxoprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Loxoprofen.
LumiracoxibThe risk or severity of adverse effects can be increased when Lisinopril is combined with Lumiracoxib.
MacitentanLisinopril may increase the hypotensive activities of Macitentan.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Lisinopril is combined with Magnesium salicylate.
ManidipineLisinopril may increase the hypotensive activities of Manidipine.
MannitolThe risk or severity of adverse effects can be increased when Lisinopril is combined with Mannitol.
MasoprocolThe risk or severity of adverse effects can be increased when Lisinopril is combined with Masoprocol.
MebanazineMebanazine may increase the hypotensive activities of Lisinopril.
MecamylamineMecamylamine may increase the hypotensive activities of Lisinopril.
Meclofenamic acidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Meclofenamic acid.
Mefenamic acidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Mefenamic acid.
MeloxicamThe risk or severity of adverse effects can be increased when Lisinopril is combined with Meloxicam.
MesalazineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Mesalazine.
MesalazineMesalazine may decrease the antihypertensive activities of Lisinopril.
MetamizoleThe risk or severity of adverse effects can be increased when Lisinopril is combined with Metamizole.
MethazolamideThe risk or severity of adverse effects can be increased when Methazolamide is combined with Lisinopril.
MethohexitalMethohexital may increase the hypotensive activities of Lisinopril.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Lisinopril.
MethyclothiazideMethyclothiazide may increase the hypotensive activities of Lisinopril.
MethyclothiazideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Methyclothiazide.
MethyldopaLisinopril may increase the hypotensive activities of Methyldopa.
Methylene blueMethylene blue may increase the hypotensive activities of Lisinopril.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Lisinopril.
MethylphenobarbitalMethylphenobarbital may increase the hypotensive activities of Lisinopril.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Lisinopril.
MetipranololLisinopril may increase the hypotensive activities of Metipranolol.
MetolazoneMetolazone may increase the hypotensive activities of Lisinopril.
MetoprololMetoprolol may increase the hypotensive activities of Lisinopril.
MibefradilLisinopril may increase the hypotensive activities of Mibefradil.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Lisinopril.
MinaprineMinaprine may increase the hypotensive activities of Lisinopril.
MinoxidilMinoxidil may increase the hypotensive activities of Lisinopril.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Lisinopril.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Lisinopril.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Lisinopril.
MoclobemideMoclobemide may increase the hypotensive activities of Lisinopril.
MoexiprilMoexipril may increase the hypotensive activities of Lisinopril.
MolsidomineMolsidomine may increase the hypotensive activities of Lisinopril.
MorphineThe serum concentration of Morphine can be increased when it is combined with Lisinopril.
MoxonidineLisinopril may increase the hypotensive activities of Moxonidine.
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Mycophenolate mofetil.
Mycophenolic acidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Mycophenolic acid.
NabumetoneThe risk or severity of adverse effects can be increased when Lisinopril is combined with Nabumetone.
NadololLisinopril may increase the hypotensive activities of Nadolol.
NadroparinNadroparin may increase the hyperkalemic activities of Lisinopril.
NaftifineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Naftifine.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Lisinopril.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Lisinopril.
NaproxenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Naproxen.
NCX 4016The risk or severity of adverse effects can be increased when Lisinopril is combined with NCX 4016.
NebivololLisinopril may increase the hypotensive activities of Nebivolol.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Lisinopril.
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Lisinopril.
NepafenacThe risk or severity of adverse effects can be increased when Lisinopril is combined with Nepafenac.
NesiritideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Nesiritide.
NialamideNialamide may increase the hypotensive activities of Lisinopril.
NicardipineNicardipine may increase the hypotensive activities of Lisinopril.
NicorandilNicorandil may increase the hypotensive activities of Lisinopril.
NifedipineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Nifedipine.
Niflumic AcidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Niflumic Acid.
NiguldipineLisinopril may increase the hypotensive activities of Niguldipine.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Lisinopril.
NilvadipineLisinopril may increase the hypotensive activities of Nilvadipine.
NimesulideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Nimesulide.
NimodipineNimodipine may increase the hypotensive activities of Lisinopril.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Lisinopril.
NisoldipineNisoldipine may increase the hypotensive activities of Lisinopril.
NitrendipineLisinopril may increase the hypotensive activities of Nitrendipine.
NitroglycerinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Nitroglycerin.
NitroprussideNitroprusside may increase the hypotensive activities of Lisinopril.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Lisinopril.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Lisinopril.
ObinutuzumabLisinopril may increase the hypotensive activities of Obinutuzumab.
OctamoxinOctamoxin may increase the hypotensive activities of Lisinopril.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Lisinopril.
OlmesartanOlmesartan may increase the hypotensive activities of Lisinopril.
OlopatadineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Olopatadine.
OlsalazineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Olsalazine.
OmapatrilatLisinopril may increase the hypotensive activities of Omapatrilat.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Lisinopril.
OrgoteinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Orgotein.
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Lisinopril.
OxaprozinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Oxaprozin.
OxprenololLisinopril may increase the hypotensive activities of Oxprenolol.
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Lisinopril is combined with Oxyphenbutazone.
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Lisinopril.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Lisinopril.
PapaverineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Papaverine.
ParecoxibThe risk or severity of adverse effects can be increased when Lisinopril is combined with Parecoxib.
PargylineLisinopril may increase the hypotensive activities of Pargyline.
ParnaparinParnaparin may increase the hyperkalemic activities of Lisinopril.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Lisinopril.
PenbutololLisinopril may increase the hypotensive activities of Penbutolol.
PentobarbitalPentobarbital may increase the hypotensive activities of Lisinopril.
PentoliniumLisinopril may increase the hypotensive activities of Pentolinium.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Lisinopril.
PerindoprilLisinopril may increase the hypotensive activities of Perindopril.
PethidineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Pethidine.
PhenelzinePhenelzine may increase the hypotensive activities of Lisinopril.
PheniprazinePheniprazine may increase the hypotensive activities of Lisinopril.
PhenobarbitalPhenobarbital may increase the hypotensive activities of Lisinopril.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Lisinopril.
PhenoxybenzamineLisinopril may increase the hypotensive activities of Phenoxybenzamine.
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Lisinopril.
PhentolaminePhentolamine may increase the hypotensive activities of Lisinopril.
PhenylbutazoneThe risk or severity of adverse effects can be increased when Lisinopril is combined with Phenylbutazone.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Lisinopril.
PimecrolimusThe risk or severity of adverse effects can be increased when Lisinopril is combined with Pimecrolimus.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Lisinopril.
PinacidilLisinopril may increase the hypotensive activities of Pinacidil.
PindololLisinopril may increase the hypotensive activities of Pindolol.
PiretanidePiretanide may increase the hypotensive activities of Lisinopril.
PirfenidoneThe risk or severity of adverse effects can be increased when Lisinopril is combined with Pirfenidone.
PirlindolePirlindole may increase the hypotensive activities of Lisinopril.
PiroxicamThe risk or severity of adverse effects can be increased when Lisinopril is combined with Piroxicam.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Lisinopril.
PivhydrazinePivhydrazine may increase the hypotensive activities of Lisinopril.
PolythiazideLisinopril may increase the hypotensive activities of Polythiazide.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Lisinopril.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Lisinopril.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Lisinopril.
PrazosinPrazosin may increase the hypotensive activities of Lisinopril.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Lisinopril.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Lisinopril.
PregabalinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Pregabalin.
PrimidonePrimidone may increase the hypotensive activities of Lisinopril.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Lisinopril.
PropacetamolThe risk or severity of adverse effects can be increased when Lisinopril is combined with Propacetamol.
PropranololPropranolol may increase the hypotensive activities of Lisinopril.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Lisinopril.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Lisinopril.
PTC299The risk or severity of adverse effects can be increased when Lisinopril is combined with PTC299.
QuetiapineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Quetiapine.
QuinaprilLisinopril may increase the hypotensive activities of Quinapril.
QuinethazoneQuinethazone may increase the hypotensive activities of Lisinopril.
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Lisinopril.
QuinineQuinine may increase the hypotensive activities of Lisinopril.
QuinineThe serum concentration of Quinine can be increased when it is combined with Lisinopril.
RamiprilRamipril may increase the hypotensive activities of Lisinopril.
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Lisinopril.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Lisinopril.
RasagilineRasagiline may increase the hypotensive activities of Lisinopril.
RemikirenRemikiren may increase the hypotensive activities of Lisinopril.
RescinnamineLisinopril may increase the hypotensive activities of Rescinnamine.
ReserpineReserpine may increase the hypotensive activities of Lisinopril.
ResveratrolThe risk or severity of adverse effects can be increased when Lisinopril is combined with Resveratrol.
ReviparinReviparin may increase the hyperkalemic activities of Lisinopril.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Lisinopril.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Lisinopril.
RiociguatLisinopril may increase the hypotensive activities of Riociguat.
RisperidoneLisinopril may increase the hypotensive activities of Risperidone.
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Lisinopril.
RituximabLisinopril may increase the hypotensive activities of Rituximab.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Lisinopril.
RofecoxibThe risk or severity of adverse effects can be increased when Lisinopril is combined with Rofecoxib.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Lisinopril.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Lisinopril.
SacubitrilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Sacubitril.
SafrazineSafrazine may increase the hypotensive activities of Lisinopril.
SalicylamideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Salicylamide.
Salicylic acidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Salicylic acid.
Salicylic acidSalicylic acid may decrease the antihypertensive activities of Lisinopril.
SalsalateThe risk or severity of adverse effects can be increased when Lisinopril is combined with Salsalate.
SaprisartanLisinopril may increase the hypotensive activities of Saprisartan.
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Lisinopril.
SaralasinThe risk or severity of adverse effects can be increased when Saralasin is combined with Lisinopril.
SaxagliptinThe risk or severity of adverse effects can be increased when Saxagliptin is combined with Lisinopril.
SecobarbitalSecobarbital may increase the hypotensive activities of Lisinopril.
SelegilineSelegiline may increase the hypotensive activities of Lisinopril.
SelexipagLisinopril may increase the hypotensive activities of Selexipag.
SeratrodastThe risk or severity of adverse effects can be increased when Lisinopril is combined with Seratrodast.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Lisinopril.
SildenafilSildenafil may increase the antihypertensive activities of Lisinopril.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Lisinopril.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Lisinopril.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Lisinopril.
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Lisinopril.
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Lisinopril.
SitagliptinThe risk or severity of adverse effects can be increased when Sitagliptin is combined with Lisinopril.
SitaxentanLisinopril may increase the hypotensive activities of Sitaxentan.
Sodium aurothiomalateThe risk or severity of adverse effects can be increased when Lisinopril is combined with Sodium aurothiomalate.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Lisinopril.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Lisinopril.
SotalolThe risk or severity of adverse effects can be increased when Sotalol is combined with Lisinopril.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Lisinopril.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Lisinopril.
SpiraprilLisinopril may increase the hypotensive activities of Spirapril.
SpironolactoneThe risk or severity of adverse effects can be increased when Spironolactone is combined with Lisinopril.
SRT501The risk or severity of adverse effects can be increased when Lisinopril is combined with SRT501.
St. John's WortThe metabolism of Lisinopril can be increased when combined with St. John's Wort.
SulfasalazineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Sulfasalazine.
SulindacThe risk or severity of adverse effects can be increased when Lisinopril is combined with Sulindac.
SuprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Suprofen.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Lisinopril.
TadalafilTadalafil may increase the antihypertensive activities of Lisinopril.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Lisinopril.
TasosartanThe risk or severity of adverse effects can be increased when Tasosartan is combined with Lisinopril.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Lisinopril.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lisinopril.
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Lisinopril.
TelmisartanLisinopril may increase the hypotensive activities of Telmisartan.
TemocaprilLisinopril may increase the hypotensive activities of Temocapril.
TemsirolimusThe risk or severity of adverse effects can be increased when Temsirolimus is combined with Lisinopril.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Lisinopril.
TenoxicamThe risk or severity of adverse effects can be increased when Lisinopril is combined with Tenoxicam.
TepoxalinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Tepoxalin.
TerazosinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Terazosin.
TeriflunomideThe risk or severity of adverse effects can be increased when Lisinopril is combined with Teriflunomide.
TerlipressinLisinopril may increase the hypotensive activities of Terlipressin.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Lisinopril.
ThiamylalThiamylal may increase the hypotensive activities of Lisinopril.
ThiopentalThiopental may increase the hypotensive activities of Lisinopril.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Lisinopril.
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Tiaprofenic acid.
TiboloneLisinopril may increase the hypotensive activities of Tibolone.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Lisinopril.
TicrynafenLisinopril may increase the hypotensive activities of Ticrynafen.
TimololTimolol may increase the hypotensive activities of Lisinopril.
TinzaparinTinzaparin may increase the hyperkalemic activities of Lisinopril.
TipranavirThe serum concentration of Lisinopril can be decreased when it is combined with Tipranavir.
TizanidineTizanidine may increase the hypotensive activities of Lisinopril.
TizanidineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Tizanidine.
TolazolineLisinopril may increase the hypotensive activities of Tolazoline.
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Lisinopril is combined with Tolfenamic Acid.
TolmetinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Tolmetin.
ToloxatoneToloxatone may increase the hypotensive activities of Lisinopril.
TolvaptanTolvaptan may increase the hyperkalemic activities of Lisinopril.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Lisinopril.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Lisinopril.
TorasemideTorasemide may increase the hypotensive activities of Lisinopril.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Lisinopril.
TrandolaprilTrandolapril may increase the hypotensive activities of Lisinopril.
TranilastThe risk or severity of adverse effects can be increased when Lisinopril is combined with Tranilast.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Lisinopril.
TranylcypromineTranylcypromine may increase the hypotensive activities of Lisinopril.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Lisinopril.
TravoprostTravoprost may increase the hypotensive activities of Lisinopril.
TreprostinilTreprostinil may increase the hypotensive activities of Lisinopril.
TriamtereneThe risk or severity of adverse effects can be increased when Triamterene is combined with Lisinopril.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Lisinopril.
TrichlormethiazideLisinopril may increase the hypotensive activities of Trichlormethiazide.
TrimazosinLisinopril may increase the hypotensive activities of Trimazosin.
TrimethaphanLisinopril may increase the hypotensive activities of Trimethaphan.
TrimethoprimTrimethoprim may increase the hyperkalemic activities of Lisinopril.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Lisinopril.
Trisalicylate-cholineThe risk or severity of adverse effects can be increased when Lisinopril is combined with Trisalicylate-choline.
UdenafilUdenafil may increase the antihypertensive activities of Lisinopril.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Lisinopril.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Lisinopril.
UnoprostoneLisinopril may increase the hypotensive activities of Unoprostone.
ValdecoxibThe risk or severity of adverse effects can be increased when Lisinopril is combined with Valdecoxib.
ValsartanValsartan may increase the hypotensive activities of Lisinopril.
VardenafilVardenafil may increase the antihypertensive activities of Lisinopril.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Lisinopril.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Lisinopril.
VerapamilThe risk or severity of adverse effects can be increased when Verapamil is combined with Lisinopril.
VildagliptinThe risk or severity of adverse effects can be increased when Vildagliptin is combined with Lisinopril.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Lisinopril.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Lisinopril.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Lisinopril.
XylometazolineLisinopril may increase the hypotensive activities of Xylometazoline.
YohimbineYohimbine may decrease the antihypertensive activities of Lisinopril.
ZaltoprofenThe risk or severity of adverse effects can be increased when Lisinopril is combined with Zaltoprofen.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Lisinopril.
ZileutonThe risk or severity of adverse effects can be increased when Lisinopril is combined with Zileuton.
ZomepiracThe risk or severity of adverse effects can be increased when Lisinopril is combined with Zomepirac.
Food Interactions
  • Herbs that may attenuate the antihypertensive effect of lisinopril include: bayberry, blue cohash, cayenne, ephedra, ginger, ginseng (American), kola and licorice.
  • High salt intake may attenuate the antihypertensive effect of lisinopril.
  • Lisinopril decreases the excretion of potassium. Salt substitutes containing potassium increase the risk of hyperkalemia.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Gene Name:
ACE
Uniprot ID:
P12821
Molecular Weight:
149713.675 Da
References
  1. Andujar-Sanchez M, Jara-Perez V, Camara-Artigas A: Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett. 2007 Jul 24;581(18):3449-54. Epub 2007 Jun 27. [PubMed:17618628 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Piepho RW: Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7. [PubMed:11030016 ]
  4. Song JC, White CM: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. [PubMed:11929321 ]
  5. Tellez-Sanz R, Garcia-Fuentes L, Baron C: Calorimetric analysis of lisinopril binding to angiotensin I-converting enzyme. FEBS Lett. 1998 Feb 13;423(1):75-80. [PubMed:9506845 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function.(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63.
Gene Name:
ACE2
Uniprot ID:
Q9BYF1
Molecular Weight:
92462.4 Da
References
  1. Parish RC, Miller LJ: Adverse effects of angiotensin converting enzyme (ACE) inhibitors. An update. Drug Saf. 1992 Jan-Feb;7(1):14-31. [PubMed:1536695 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Piepho RW: Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7. [PubMed:11030016 ]
  4. Song JC, White CM: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. [PubMed:11929321 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. [PubMed:11895100 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Proton-dependent oligopeptide secondary active transmembrane transporter activity
Specific Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
Gene Name:
SLC15A1
Uniprot ID:
P46059
Molecular Weight:
78805.265 Da
References
  1. Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. [PubMed:15618677 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23