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Identification
NameLisinopril
Accession NumberDB00722  (APRD00560)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.

Structure
Thumb
Synonyms
(S)-1-(N(2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline
[N2-[(S)-1-CARBOXY-3-phenylpropyl]-L-lysyl-L-proline
Lisinopril
Lisinopril anhydrous
Lisinoprilum
External Identifiers
  • L 154826
  • MK 521
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Act Lisinopriltablet20 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Act Lisinopriltablet10 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Act Lisinopriltablet5 mgoralActavis Pharma Company2007-10-17Not applicableCanada
Auro-lisinopriltablet20 mgoralAuro Pharma Inc2013-02-12Not applicableCanada
Auro-lisinopriltablet10 mgoralAuro Pharma Inc2013-02-12Not applicableCanada
Auro-lisinopriltablet5 mgoralAuro Pharma Inc2013-02-12Not applicableCanada
Dom-lisinopriltablet20 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Dom-lisinopriltablet10 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Dom-lisinopriltablet5 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Ipg-lisinopriltablet10 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-lisinopriltablet5 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Ipg-lisinopriltablet20 mgoralInternational Pharmaceutical Generics LtdNot applicableNot applicableCanada
Jamp-lisinopriltablet20 mgoralJamp Pharma Corporation2011-02-04Not applicableCanada
Jamp-lisinopriltablet10 mgoralJamp Pharma Corporation2011-02-04Not applicableCanada
Jamp-lisinopriltablet5 mgoralJamp Pharma Corporation2011-02-04Not applicableCanada
Lisinopriltablet5 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lisinopriltablet20 mgoralSorres Pharma Inc2009-06-222014-06-20Canada
Lisinopriltablet20 mgoralMeliapharm Inc2008-03-122014-06-25Canada
Lisinopriltablet10 mgoralMeliapharm Inc2008-03-122014-06-25Canada
Lisinopriltablet10 mgoralSorres Pharma Inc2009-06-222014-06-20Canada
Lisinopriltablet5 mgoralSorres Pharma Inc2009-06-222014-06-20Canada
Lisinopriltablet40 mgoralSivem Pharmaceuticals UlcNot applicableNot applicableCanada
Lisinopriltablet5 mgoralMeliapharm Inc2008-03-122014-06-25Canada
Lisinopriltablet20 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Lisinopriltablet20 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lisinopriltablet10 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Lisinopriltablet10 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Lisinopriltablet5 mgoralSivem Pharmaceuticals Ulc2012-06-11Not applicableCanada
Lisinopril Tabletstablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Lisinopril Tabletstablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Lisinopril Tabletstablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Lisinopril Tablets USPtablet20 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Lisinopril Tablets USPtablet10 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Lisinopril Tablets USPtablet5 mgoralLUPIN LIMITEDNot applicableNot applicableCanada
Mar-lisinopriltablet20 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-lisinopriltablet10 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mar-lisinopriltablet5 mgoralMarcan Pharmaceuticals IncNot applicableNot applicableCanada
Mint-lisinopriltablet5 mgoralMint Pharmaceuticals Inc2008-10-282012-08-02Canada
Mint-lisinopriltablet20 mgoralMint Pharmaceuticals Inc2008-10-282012-08-02Canada
Mint-lisinopriltablet10 mgoralMint Pharmaceuticals Inc2008-10-282012-08-02Canada
Mylan-lisinopriltablet20 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Mylan-lisinopriltablet10 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Mylan-lisinopriltablet5 mgoralMylan Pharmaceuticals Ulc2007-10-17Not applicableCanada
Nu-lisinopriltablet40 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet20 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet20 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet10 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet10 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet5 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet5 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-lisinopriltablet40 mgoralNu Pharm IncNot applicableNot applicableCanada
PMS-lisinopriltablet5 mgoralPharmascience Inc2007-10-17Not applicableCanada
PMS-lisinopriltablet20 mgoralPharmascience Inc2007-10-17Not applicableCanada
PMS-lisinopriltablet10 mgoralPharmascience Inc2007-10-17Not applicableCanada
Priniviltablet5 mgoralMerck Canada Inc1990-12-31Not applicableCanada
Priniviltablet5 mg/1oralMerck Sharp & Dohme Corp.1987-12-29Not applicableUs
Priniviltablet10 mgoralMerck Canada Inc1990-12-31Not applicableCanada
Priniviltablet2.5 mgoralMerck Canada Inc2000-01-052005-06-23Canada
Priniviltablet20 mg/1oralMerck Sharp & Dohme Corp.1987-12-29Not applicableUs
Priniviltablet20 mgoralMerck Canada Inc1990-12-31Not applicableCanada
Priniviltablet10 mg/1oralMerck Sharp & Dohme Corp.1987-12-29Not applicableUs
Pro-lisinopril - 10tablet10 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Pro-lisinopril - 20tablet20 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Pro-lisinopril - 5tablet5 mgoralPro Doc Limitee2008-07-03Not applicableCanada
Ran-lisinopriltablet20 mgoralRanbaxy Pharmaceuticals Canada Inc.2007-10-17Not applicableCanada
Ran-lisinopriltablet10 mgoralRanbaxy Pharmaceuticals Canada Inc.2007-10-17Not applicableCanada
Ran-lisinopriltablet5 mgoralRanbaxy Pharmaceuticals Canada Inc.2007-10-17Not applicableCanada
Ratio-lisinopril Ptablet5 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ptablet20 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ptablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ztablet20 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ztablet10 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Ratio-lisinopril Ztablet5 mgoralRatiopharm Inc Division Of Teva Canada Limited2007-10-172014-09-19Canada
Riva-lisinopriltablet20 mgoralLaboratoire Riva Inc2007-10-26Not applicableCanada
Riva-lisinopriltablet10 mgoralLaboratoire Riva Inc2007-10-26Not applicableCanada
Riva-lisinopriltablet5 mgoralLaboratoire Riva Inc2007-10-26Not applicableCanada
Sandoz Lisinopriltablet20 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Sandoz Lisinopriltablet10 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Sandoz Lisinopriltablet5 mgoralSandoz Canada Incorporated2007-10-17Not applicableCanada
Teva-lisinopril (type P)tablet5 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type P)tablet20 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type P)tablet10 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type Z)tablet20 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type Z)tablet10 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Teva-lisinopril (type Z)tablet5 mgoralTeva Canada Limited2007-10-17Not applicableCanada
Zestriltablet2.5 mg/1oralAstra Zeneca Pharmaceuticals Lp2011-09-02Not applicableUs
Zestriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2011-11-09Not applicableUs
Zestriltablet40 mg/1oralAstra Zeneca Pharmaceuticals Lp2010-03-26Not applicableUs
Zestriltablet40 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet30 mg/1oralAstra Zeneca Pharmaceuticals Lp2010-09-22Not applicableUs
Zestriltablet30 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet20 mg/1oralAstra Zeneca Pharmaceuticals Lp2009-05-13Not applicableUs
Zestriltablet20 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet10 mg/1oralAstra Zeneca Pharmaceuticals Lp2009-08-28Not applicableUs
Zestriltablet10 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet5 mg/1oralAstra Zeneca Pharmaceuticals Lp2009-11-11Not applicableUs
Zestriltablet5 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestriltablet2.5 mg/1oralALMATICA PHARMA INC.2015-04-07Not applicableUs
Zestril Tab 10mgtablet10 mgoralAstrazeneca Canada Inc1994-12-31Not applicableCanada
Zestril Tab 20mgtablet20 mgoralAstrazeneca Canada Inc1994-12-31Not applicableCanada
Zestril Tab 5mgtablet5 mgoralAstrazeneca Canada Inc1994-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-lisinopril Tablet (type P) - 10mgtablet10 mgoralApotex Inc1996-10-302001-08-02Canada
Apo-lisinopril Tablet (type P) - 20mgtablet20 mgoralApotex Inc1996-10-302001-08-02Canada
Apo-lisinopril Tablet (type P) - 40mgtablet40 mgoralApotex Inc1996-12-302001-08-02Canada
Apo-lisinopril Tablet (type P) - 5mgtablet5 mgoralApotex Inc1996-10-302001-08-02Canada
Apo-lisinopril Tablet 10 mgtablet10 mgoralApotex Inc1996-10-30Not applicableCanada
Apo-lisinopril Tablet 20 mgtablet20 mgoralApotex Inc1996-10-30Not applicableCanada
Apo-lisinopril Tablet 40 mgtablet40 mgoralApotex Inc1996-10-30Not applicableCanada
Apo-lisinopril Tablet 5 mgtablet5 mgoralApotex Inc1996-10-30Not applicableCanada
Lisinopriltablet5 mg/1oralPhysicians Total Care, Inc.2008-04-10Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet30 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralHikma Pharmaceutical2013-08-22Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2012-10-05Not applicableUs
Lisinopriltablet10 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet2.5 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Lisinopriltablet10 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet2.5 mg/1oralApotex Corp.2008-06-26Not applicableUs
Lisinopriltablet5 mg/1oralProficient Rx LP2011-11-01Not applicableUs
Lisinopriltablet10 mg/1oralHikma Pharmaceutical2013-08-22Not applicableUs
Lisinopriltablet20 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lisinopriltablet40 mg/1oralReady Meds2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralSt Marys Medical Park Pharmacy2013-05-16Not applicableUs
Lisinopriltablet20 mg/1oralbryant ranch prepack2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralMed Vantx, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet20 mg/1oralTYA Pharmaceuticals2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet20 mg/1oralBlue Point Laboratories2015-07-06Not applicableUs
Lisinopriltablet2.5 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet5 mg/1oralPreferred Pharmaceuticals Inc.2016-04-12Not applicableUs
Lisinopriltablet5 mg/1oralBlenheim Pharmacal, Inc.2014-02-28Not applicableUs
Lisinopriltablet20 mg/1oralRed Pharm Drug Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals, Inc.2013-05-02Not applicableUs
Lisinopriltablet5 mg/1oralMajor Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralMed Vantx, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralRebel Distributors Corp2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralDispensing Solutions, Inc.2005-11-17Not applicableUs
Lisinopriltablet40 mg/1oralMajor Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not applicableUs
Lisinopriltablet40 mg/1oralMc Kesson Contract Packaging2011-09-16Not applicableUs
Lisinopriltablet5 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet30 mg/1oralBlue Point Laboratories2015-07-06Not applicableUs
Lisinopriltablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralAidarex Pharmaceuticals LLC2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Lisinopriltablet40 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet, film coated5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet30 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet5 mg/1oralPreferred Pharmaceuticals, Inc.2013-12-03Not applicableUs
Lisinopriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet40 mg/1oralLake Erie Medical Quality Care Products LLC2012-03-27Not applicableUs
Lisinopriltablet40 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2011-03-29Not applicableUs
Lisinopriltablet10 mg/1oralWest Ward Pharmaceuticals Corp2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet40 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralMedsource Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralMylan Institutional Inc.2002-08-01Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2013-12-23Not applicableUs
Lisinopriltablet40 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-06-24Not applicableUs
Lisinopriltablet30 mg/1oralLake Erie Medical DBA Quality Care Products LLC2007-02-15Not applicableUs
Lisinopriltablet2.5 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet20 mg/1oralWest Ward Pharmaceuticals Corp2013-02-13Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2012-12-31Not applicableUs
Lisinopriltablet30 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Lisinopriltablet5 mg/1oralNorthwind Pharmaceuticals, LLC2014-07-30Not applicableUs
Lisinopriltablet40 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Lisinopriltablet20 mg/1oralPhysicians Total Care, Inc.2007-09-17Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Lisinopriltablet5 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet2.5 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2012-10-05Not applicableUs
Lisinopriltablet40 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Lisinopriltablet30 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2012-08-27Not applicableUs
Lisinopriltablet5 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet, film coated2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet40 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet20 mg/1oralProficient Rx LP2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Lisinopriltablet20 mg/1oralReady Meds2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralbryant ranch prepack2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet20 mg/1oralTYA Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralSTAT Rx USA LLC2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralBlue Point Laboratories2015-07-06Not applicableUs
Lisinopriltablet40 mg/1oralBlenheim Pharmacal, Inc.2010-05-20Not applicableUs
Lisinopriltablet10 mg/1oralRed Pharm Drug Inc.2005-11-17Not applicableUs
Lisinopriltablet10 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals Inc.2015-10-28Not applicableUs
Lisinopriltablet20 mg/1oralRebel Distributors Corp2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralCarilion Materials Management2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralMajor Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralRx Change Co.2014-11-12Not applicableUs
Lisinopriltablet20 mg/1oralMc Kesson Contract Packaging2011-09-09Not applicableUs
Lisinopriltablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals, Inc2012-04-05Not applicableUs
Lisinopriltablet30 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet30 mg/1oralAmerican Health Packaging2014-12-152015-12-29Us
Lisinopriltablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-07-19Not applicableUs
Lisinopriltablet30 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralREMEDYREPACK INC.2011-04-14Not applicableUs
Lisinopriltablet5 mg/1oralWest Ward Pharmaceuticals Corp2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet30 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralMylan Institutional Inc.2002-08-01Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2013-12-23Not applicableUs
Lisinopriltablet20 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-05-16Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-03-20Not applicableUs
Lisinopriltablet40 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Lisinopriltablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet10 mg/1oralPhysicians Total Care, Inc.2005-07-25Not applicableUs
Lisinopriltablet2.5 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet5 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2012-08-27Not applicableUs
Lisinopriltablet2.5 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralHikma Pharmaceutical2013-08-22Not applicableUs
Lisinopriltablet20 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet20 mg/1oralSt Marys Medical Park Pharmacy2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralReady Meds2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralbryant ranch prepack2005-11-17Not applicableUs
Lisinopriltablet30 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet10 mg/1oralTYA Pharmaceuticals2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralSTAT Rx USA LLC2007-04-19Not applicableUs
Lisinopriltablet30 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet20 mg/1oralBlenheim Pharmacal, Inc.2009-12-16Not applicableUs
Lisinopriltablet20 mg/1oralRed Pharm Drug Inc.2002-07-02Not applicableUs
Lisinopriltablet5 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals Inc.2015-10-29Not applicableUs
Lisinopriltablet10 mg/1oralRebel Distributors Corp2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralAmerican Health Packaging2014-06-02Not applicableUs
Lisinopriltablet10 mg/1oralMajor Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralRx Change Co.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralMc Kesson Contract Packaging2011-09-08Not applicableUs
Lisinopriltablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals, Inc2012-04-05Not applicableUs
Lisinopriltablet20 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet40 mg/1oralAmerican Health Packaging2005-09-222015-12-05Us
Lisinopriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet10 mg/1oralLake Erie Medical Quality Care Products LLC2012-03-27Not applicableUs
Lisinopriltablet20 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralREMEDYREPACK INC.2011-04-20Not applicableUs
Lisinopriltablet20 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet20 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2011-09-29Not applicableUs
Lisinopriltablet10 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralREMEDYREPACK INC.2013-05-14Not applicableUs
Lisinopriltablet2.5 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs
Lisinopriltablet2.5 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Lisinopriltablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralPhysicians Total Care, Inc.2009-02-16Not applicableUs
Lisinopriltablet5 mg/1oralLiberty Pharmaceuticals, Inc.2007-04-19Not applicableUs
Lisinopriltablet5 mg/1oralInternational Labs, Inc.2012-02-20Not applicableUs
Lisinopriltablet40 mg/1oralEon Labs, Inc.2015-06-09Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2012-08-27Not applicableUs
Lisinopriltablet40 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet2.5 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet30 mg/1oralAmerican Health Packaging2015-10-01Not applicableUs
Lisinopriltablet30 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet20 mg/1oralProficient Rx LP2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2015-12-23Not applicableUs
Lisinopriltablet10 mg/1oralSTAT Rx USA LLC2005-11-17Not applicableUs
Lisinopriltablet2.5 mg/1oralBlue Point Laboratories2014-07-31Not applicableUs
Lisinopriltablet10 mg/1oralBlenheim Pharmacal, Inc.2009-12-16Not applicableUs
Lisinopriltablet20 mg/1oralContract Pharmacy Services Pa2002-08-02Not applicableUs
Lisinopriltablet2.5 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet40 mg/1oralPreferred Pharmaceuticals Inc.2015-08-28Not applicableUs
Lisinopriltablet5 mg/1oralRebel Distributors Corp2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralAmerican Health Packaging2013-12-23Not applicableUs
Lisinopriltablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2015-06-09Not applicableUs
Lisinopriltablet5 mg/1oralRx Change Co.2014-11-18Not applicableUs
Lisinopriltablet5 mg/1oralMc Kesson Contract Packaging2011-09-07Not applicableUs
Lisinopriltablet2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-02Not applicableUs
Lisinopriltablet20 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet40 mg/1oralPreferred Pharmaceuticals, Inc2012-04-05Not applicableUs
Lisinopriltablet10 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet20 mg/1oralAmerican Health Packaging2005-09-222015-12-29Us
Lisinopriltablet40 mg/1oralPd Rx Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2011-09-29Not applicableUs
Lisinopriltablet10 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2010-11-15Not applicableUs
Lisinopriltablet10 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet10 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralKAISER FOUNDATION HOSPITALS2008-11-03Not applicableUs
Lisinopriltablet2.5 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet5 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralREMEDYREPACK INC.2013-05-13Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-02-26Not applicableUs
Lisinopriltablet10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Lisinopriltablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet40 mg/1oralPhysicians Total Care, Inc.2004-08-25Not applicableUs
Lisinopriltablet30 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralInternational Labs, Inc.2012-02-20Not applicableUs
Lisinopriltablet30 mg/1oralEon Labs, Inc.2015-08-19Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2005-09-22Not applicableUs
Lisinopriltablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2005-11-17Not applicableUs
Lisinopriltablet2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2005-09-22Not applicableUs
Lisinopriltablet5 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet40 mg/1oralApotex Corp.2008-01-22Not applicableUs
Lisinopriltablet20 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet40 mg/1oralProficient Rx LP2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2015-07-22Not applicableUs
Lisinopriltablet5 mg/1oralReady Meds2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralRanbaxy Pharmaceuticals Inc.2006-05-15Not applicableUs
Lisinopriltablet20 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet30 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2015-05-23Not applicableUs
Lisinopriltablet30 mg/1oralAidarex Pharmaceuticals LLC2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralMc Kesson Contract Packaging2011-09-01Not applicableUs
Lisinopriltablet, film coated40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet5 mg/1oralPreferred Pharmaceuticals Inc.2015-08-20Not applicableUs
Lisinopriltablet5 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet10 mg/1oralAmerican Health Packaging2005-09-222015-12-29Us
Lisinopriltablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2011-05-19Not applicableUs
Lisinopriltablet5 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2010-11-10Not applicableUs
Lisinopriltablet5 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet5 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet20 mg/1oralKAISER FOUNDATION HOSPITALS2008-11-03Not applicableUs
Lisinopriltablet20 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet2.5 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Lisinopriltablet20 mg/1oralNorthwind Pharmaceuticals, LLC2014-11-21Not applicableUs
Lisinopriltablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralAidarex Pharmaceuticals LLC2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet40 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralInternational Laboratories, Inc.2015-05-12Not applicableUs
Lisinopriltablet20 mg/1oralEon Labs, Inc.2015-05-23Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2005-09-22Not applicableUs
Lisinopriltablet2.5 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet30 mg/1oralApotex Corp.2002-10-09Not applicableUs
Lisinopriltablet10 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet20 mg/1oralProficient Rx LP2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2015-03-25Not applicableUs
Lisinopriltablet20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet10 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet40 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralBlenheim Pharmacal, Inc.2015-02-19Not applicableUs
Lisinopriltablet10 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet40 mg/1oralMajor Pharmaceuticals2015-06-15Not applicableUs
Lisinopriltablet20 mg/1oralContract Pharmacy Services Pa2010-08-12Not applicableUs
Lisinopriltablet20 mg/1oralREMEDYREPACK INC.2013-02-28Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals Inc.2015-08-28Not applicableUs
Lisinopriltablet40 mg/1oralAccord Healthcare Inc.2013-07-30Not applicableUs
Lisinopriltablet20 mg/1oralAmerican Health Packaging2013-12-23Not applicableUs
Lisinopriltablet30 mg/1oralREMEDYREPACK INC.2011-07-19Not applicableUs
Lisinopriltablet2.5 mg/1oralLUPIN LIMITED2006-01-13Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2010-09-16Not applicableUs
Lisinopriltablet2.5 mg/1oralMed Health Pharma, LLC2011-01-05Not applicableUs
Lisinopriltablet2.5 mg/1oralLupin Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralKAISER FOUNDATION HOSPITALS2008-11-03Not applicableUs
Lisinopriltablet10 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet2.5 mg/1oralWest Ward Pharmaceuticals Corp2013-02-132016-02-18Us
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Lisinopriltablet10 1/1oralNorthwind Pharmaceuticals, LLC2014-11-17Not applicableUs
Lisinopriltablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet10 mg/1oralH.J. Harkins Company, Inc.2005-11-17Not applicableUs
Lisinopriltablet5 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet20 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralInternational Laboratories, Inc.2015-05-12Not applicableUs
Lisinopriltablet10 mg/1oralEon Labs, Inc.2015-05-21Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2009-12-18Not applicableUs
Lisinopriltablet10 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2005-11-17Not applicableUs
Lisinopriltablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2012-10-05Not applicableUs
Lisinopriltablet30 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet30 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralApotex Corp.2008-06-25Not applicableUs
Lisinopriltablet5 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet10 mg/1oralProficient Rx LP2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralSt Marys Medical Park Pharmacy2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet5 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet20 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralBlenheim Pharmacal, Inc.2015-02-19Not applicableUs
Lisinopriltablet40 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet20 mg/1oralMajor Pharmaceuticals2015-06-15Not applicableUs
Lisinopriltablet10 mg/1oralContract Pharmacy Services Pa2002-07-02Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-05-20Not applicableUs
Lisinopriltablet20 mg/1oralLegacy Pharmaceutical Packaging, Llc2006-01-13Not applicableUs
Lisinopriltablet30 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet10 mg/1oralAmerican Health Packaging2013-12-23Not applicableUs
Lisinopriltablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2015-05-21Not applicableUs
Lisinopriltablet5 mg/1oralAidarex Pharmaceuticals LLC2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralLife Line Home Care Services, Inc.2010-08-12Not applicableUs
Lisinopriltablet, film coated30 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet5 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet5 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Lisinopriltablet2.5 mg/1oralSolco healthcare U.S., LLC2011-11-01Not applicableUs
Lisinopriltablet5 mg/1oralAmerican Health Packaging2005-09-222015-12-29Us
Lisinopriltablet2.5 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-02Not applicableUs
Lisinopriltablet2.5 mg/1oralREMEDYREPACK INC.2013-05-08Not applicableUs
Lisinopriltablet10 mg/301oralNorthwind Pharmaceuticals2014-05-20Not applicableUs
Lisinopriltablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2014-04-04Not applicableUs
Lisinopriltablet10 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet10 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralInternational Laboratories, Inc.2015-05-12Not applicableUs
Lisinopriltablet2.5 mg/1oralEon Labs, Inc.2015-12-21Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2010-04-20Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralClinical Solutions Wholesale2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet10 mg/1oralApotex Corp.2008-04-17Not applicableUs
Lisinopriltablet2.5 mg/1oralGolden State Medical Supply, Inc.2015-01-07Not applicableUs
Lisinopriltablet40 mg/1oralDIRECT RX2015-01-01Not applicableUs
Lisinopriltablet30 mg/1oralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
Lisinopriltablet2.5 mg/1oralbryant ranch prepack2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet2.5 mg/1oralAurobindo Pharma Limited2006-02-22Not applicableUs
Lisinopriltablet10 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet5 mg/1oralBlenheim Pharmacal, Inc.2015-02-19Not applicableUs
Lisinopriltablet20 mg/1oralBlue Point Laboratories2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralMajor Pharmaceuticals2015-06-15Not applicableUs
Lisinopriltablet10 mg/1oralContract Pharmacy Services Pa2010-08-12Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-09-19Not applicableUs
Lisinopriltablet20 mg/1oralLegacy Pharmaceutical Packaging2010-10-01Not applicableUs
Lisinopriltablet20 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet5 mg/1oralAmerican Health Packaging2013-12-23Not applicableUs
Lisinopriltablet40 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralAidarex Pharmaceuticals LLC2006-01-13Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Lisinopriltablet, film coated20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet2.5 mg/1oralCamber Pharmaceuticals Inc.2013-11-15Not applicableUs
Lisinopriltablet10 mg/1oralPreferred Pharmaceuticals, Inc.2013-12-03Not applicableUs
Lisinopriltablet40 mg/1oralAphena Pharma Solutions Tennessee, Llc2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2006-01-13Not applicableUs
Lisinopriltablet2.5 mg/1oralREMEDYREPACK INC.2011-07-13Not applicableUs
Lisinopriltablet40 mg/1oralWest Ward Pharmaceuticals Corp2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralSafecor Health, LLC2014-10-01Not applicableUs
Lisinopriltablet40 mg/1oralMylan Institutional Inc.2002-08-01Not applicableUs
Lisinopriltablet5 mg/1oralREMEDYREPACK INC.2015-10-08Not applicableUs
Lisinopriltablet2.5 mg/1oralKAISER FOUNDATION HOSPITALS2013-08-05Not applicableUs
Lisinopriltablet30 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet5 mg/1oralWest Ward Pharmaceuticals Corp2013-02-13Not applicableUs
Lisinopriltablet20 mg/1oralInternational Laboratories, Inc.2008-02-01Not applicableUs
Lisinopriltablet5 mg/1oralMylan Pharmaceuticals Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralInternational Laboratories, Inc.2015-05-12Not applicableUs
Lisinopriltablet40 mg/1oralEon Labs, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralCardinal Health2012-08-27Not applicableUs
Lisinopriltablet30 mg/1oralPhysicians Total Care, Inc.2007-04-12Not applicableUs
Lisinopriltablet20 mg/1oralCardinal Health2006-01-13Not applicableUs
Lisinopriltablet40 mg/1oralQualitest Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralCardinal Health2012-10-05Not applicableUs
Lisinopriltablet20 mg/1oralWatson Laboratories, Inc.2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralCitron Pharma LLC2006-02-22Not applicableUs
Lisinopriltablet20 mg/1oralWockhardt Limited2007-04-19Not applicableUs
Lisinopriltablet5 mg/1oralApotex Corp.2008-02-18Not applicableUs
Lisinopriltablet20 mg/1oralHikma Pharmaceutical2013-08-22Not applicableUs
Lisinopriltablet5 mg/1oralDIRECT RX2015-01-01Not applicableUs
Lisinopriltablet10 mg/1oralSt Marys Medical Park Pharmacy2002-07-01Not applicableUs
Lisinopriltablet40 mg/1oralbryant ranch prepack2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralRanbaxy Pharmaceuticals Inc.2002-07-02Not applicableUs
Lisinopriltablet5 mg/1oralTYA Pharmaceuticals2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralWockhardt USA LLC.2007-04-19Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals Inc.2016-04-12Not applicableUs
Lisinopriltablet2.5 mg/1oralBlenheim Pharmacal, Inc.2014-01-14Not applicableUs
Lisinopriltablet5 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet5 mg/1oralMajor Pharmaceuticals2015-06-15Not applicableUs
Lisinopriltablet10 mg/1oralMed Vantx, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralRebel Distributors Corp2008-02-01Not applicableUs
Lisinopriltablet20 mg/1oralKeltman Pharmaceuticals Inc.2010-12-10Not applicableUs
Lisinopriltablet10 mg/1oralAccord Healthcare Inc.2013-09-15Not applicableUs
Lisinopriltablet40 mg/1oralBlue Point Laboratories2014-02-04Not applicableUs
Lisinopriltablet30 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralAidarex Pharmaceuticals LLC2002-07-01Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Lisinopriltablet, film coated10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2007-04-19Not applicableUs
Lisinopriltablet40 mg/1oralBlu Pharmaceuticals, LLC2009-02-02Not applicableUs
Lisinopriltablet20 mg/1oralPreferred Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet2.5 mg/1oralAphena Pharma Solutions Tennessee, Llc2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralExelan Pharmaceuticals Inc.2014-03-15Not applicableUs
Lisinopriltablet2.5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2002-07-01Not applicableUs
Lisinopriltablet30 mg/1oralREMEDYREPACK INC.2011-06-21Not applicableUs
Lisinopriltablet20 mg/1oralWest Ward Pharmaceuticals Corp2002-07-01Not applicableUs
Lisinopriltablet10 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Lisinopriltablet20 mg/1oralMylan Institutional Inc.2002-08-01Not applicableUs
Lisinopriltablet5 mg/1oralCardinal Health2013-12-23Not applicableUs
Lisinopriltablet30 mg/1oralIVAX Pharmaceuticals, Inc.2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralUnit Dose Services2002-07-01Not applicableUs
Lisinopriltablet5 mg/1oralAccord Healthcare Inc.2016-03-21Not applicableUs
Lisinopriltablet10 mg/1oralWest Ward Pharmaceuticals Corp2013-02-13Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-07-05Not applicableUs
Lisinopriltablet40 mg/1oralNorthwind Pharmaceuticals, LLC2015-03-10Not applicableUs
Lisinopriltablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Lisinopriltablet10 mg/1oralREMEDYREPACK INC.2013-05-28Not applicableUs
Lisinopril 10mgtablet10 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Lisinopril 2.5mgtablet2.5 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Lisinopril 20mgtablet20 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Lisinopril 40mgtablet40 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Lisinopril 5mgtablet5 mg/1oralMcKesson Contract Packaging2013-08-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AcebitorGlaxoSmithKline
AceminAstraZeneca
AcerbonAstraZeneca
Acinoprilsanofi-aventis
BellisinRanbaxy
BioprilBiochem
DaprilMedochemie
FibsolSigma
FisoprilSanofi-Aventis
HiprilMicro Labs
LinoprilKlinger (Brazil)
LisiprilHexal (Czech Republic), Orion (Finland)
NopertenDexa (Indonesia)
PresitenMagnachem
RanolipRanbaxy
RanoprilRanbaxy
RantexBiotech
SinoprenRanbaxy
SinoprilEczacibasi (Russia)
TensoprilMerck
Brand mixtures
NameLabellerIngredients
Apo-lisinopril/hctzApotex Inc
Ava-lisinopril HctAvanstra Inc
Lisinopril and HctzNorthwind Pharmaceuticals, LLC
Lisinopril and HydrochlorothiazideIVAX Pharmaceuticals, Inc.
Lisinopril and HydrochlorthiazideREMEDYREPACK INC.
Lisinopril With HydrochlorothiazideWest Ward Pharmaceuticals Corp
Lisinopril/hctz (type Z)Sanis Health Inc
Lisnopril/hctz (type P)Sanis Health Inc
Lytensopril-90Physician Therapeutics Llc
Mylan-lisinopril HctzMylan Pharmaceuticals Ulc
Ntp-lisinopril/hctz (type P)Teva Canada Limited
Ntp-lisinopril/hctz (type Z)Teva Canada Limited
Nu-lisinopril/hctzNu Pharm Inc
PrinzideMerck Canada Inc
Sandoz Lisinopril HctSandoz Canada Incorporated
Teva-lisinopril/hctz (type P)Teva Canada Limited
Teva-lisinopril/hctz (type Z)Teva Canada Limited
ZestoreticAstra Zeneca Pharmaceuticals Lp
Zestoretic Tab 10/12.5mgAstrazeneca Canada Inc
Zestoretic Tab 20/12.5mgAstrazeneca Canada Inc
Zestoretic Tab 20/25mgAstrazeneca Canada Inc
SaltsNot Available
Categories
UNIIE7199S1YWR
CAS number83915-83-7
WeightAverage: 405.4879
Monoisotopic: 405.226371117
Chemical FormulaC21H31N3O5
InChI KeyInChIKey=RLAWWYSOJDYHDC-BZSNNMDCSA-N
InChI
InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1
IUPAC Name
(2S)-1-[(2S)-6-amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]pyrrolidine-2-carboxylic acid
SMILES
NCCCC[[email protected]](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[[email protected]]1C(O)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as peptides. These are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentPeptides
Alternative Parents
Substituents
  • Alpha peptide
  • N-acyl-alpha amino acid or derivatives
  • N-acyl-alpha-amino acid
  • Alpha-amino acid amide
  • L-alpha-amino acid
  • Phenylpropylamine
  • Alpha-amino acid or derivatives
  • N-substituted-alpha-amino acid
  • Alpha-amino acid
  • Pyrrolidine carboxylic acid or derivatives
  • Pyrrolidine carboxylic acid
  • N-acylpyrrolidine
  • Aralkylamine
  • Amino fatty acid
  • Fatty acyl
  • Benzenoid
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Tertiary amine
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Secondary amine
  • Secondary aliphatic amine
  • Carboxylic acid
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or β-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
PharmacodynamicsLisinopril is an orally active ACE inhibitor that antagonizes the effect of the RAAS. The RAAS is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. During sympathetic stimulation or when renal blood pressure or blood flow is reduced, renin is released from the granular cells of the juxtaglomerular apparatus in the kidneys. In the blood stream, renin cleaves circulating angiotensinogen to ATI, which is subsequently cleaved to ATII by ACE. ATII increases blood pressure using a number of mechanisms. First, it stimulates the secretion of aldosterone from the adrenal cortex. Aldosterone travels to the distal convoluted tubule (DCT) and collecting tubule of nephrons where it increases sodium and water reabsorption by increasing the number of sodium channels and sodium-potassium ATPases on cell membranes. Second, ATII stimulates the secretion of vasopressin (also known as antidiuretic hormone or ADH) from the posterior pituitary gland. ADH stimulates further water reabsorption from the kidneys via insertion of aquaporin-2 channels on the apical surface of cells of the DCT and collecting tubules. Third, ATII increases blood pressure through direct arterial vasoconstriction. Stimulation of the Type 1 ATII receptor on vascular smooth muscle cells leads to a cascade of events resulting in myocyte contraction and vasoconstriction. In addition to these major effects, ATII induces the thirst response via stimulation of hypothalamic neurons. ACE inhibitors inhibit the rapid conversion of ATI to ATII and antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, a vasodilator. Inhibiting the deactivation of bradykinin increases bradykinin levels and may further sustain the effects of lisinopril by causing increased vasodilation and decreased blood pressure.
Mechanism of actionThere are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Lisinopril, one of the few ACE inhibitors that is not a prodrug, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Lisinopril also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors.
Related Articles
AbsorptionApproximately 25%, but widely variable between individuals (6 to 60%) in all doses tested (5-80 mg); absorption is unaffected by food
Volume of distributionNot Available
Protein bindingLisinopril does not appear to be bound to serum proteins other than ACE.
Metabolism

Does not undergo metabolism, excreted unchanged in urine.

Route of eliminationLisinopril does not undergo metabolism and is excreted unchanged entirely in the urine.
Half lifeEffective half life of accumulation following multiple dosing is 12 hours.
Clearance
  • 10 L/h [child weighting 30 kg receiving doses of 0.1 to 0.2 mg/kg]
ToxicitySymptoms of overdose include severe hypotension, electrolyte disturbances, and renal failure. LD50= 2000 mg/kg(orally in rat). Most frequent adverse effects include headache, dizziness, cough, fatigue and diarrhea.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Lisinopril Action PathwayDrug actionSMP00150
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.6426
Blood Brain Barrier-0.8815
Caco-2 permeable-0.7605
P-glycoprotein substrateSubstrate0.6515
P-glycoprotein inhibitor INon-inhibitor0.9512
P-glycoprotein inhibitor IINon-inhibitor0.969
Renal organic cation transporterNon-inhibitor0.8574
CYP450 2C9 substrateNon-substrate0.8793
CYP450 2D6 substrateNon-substrate0.7622
CYP450 3A4 substrateNon-substrate0.725
CYP450 1A2 substrateNon-inhibitor0.8999
CYP450 2C9 inhibitorNon-inhibitor0.9708
CYP450 2D6 inhibitorNon-inhibitor0.9653
CYP450 2C19 inhibitorNon-inhibitor0.8266
CYP450 3A4 inhibitorNon-inhibitor0.907
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9821
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9389
BiodegradationNot ready biodegradable0.6844
Rat acute toxicity1.8723 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9641
hERG inhibition (predictor II)Non-inhibitor0.8708
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Actavis elizabeth llc
  • Apotex inc etobicoke site
  • Aurobindo pharma ltd
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lek pharmaceuticals d d
  • Lupin ltd
  • Mylan pharmaceuticals inc
  • Ranbaxy pharmaceuticals inc
  • Sandoz inc
  • Teva pharmaceuticals usa inc
  • Vintage pharmaceuticals llc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Wockhardt ltd
  • Merck research laboratories div merck co inc
  • Astrazeneca uk ltd
Packagers
Dosage forms
FormRouteStrength
Tabletoral40 mg
Tabletoral10 1/1
Tabletoral10 mg/301
Tabletoral2.5 mg/1
Tabletoral30 mg/1
Tabletoral40 mg/1
Tablet, film coatedoral10 mg/1
Tablet, film coatedoral2.5 mg/1
Tablet, film coatedoral20 mg/1
Tablet, film coatedoral30 mg/1
Tablet, film coatedoral40 mg/1
Tablet, film coatedoral5 mg/1
Tabletoral
Kit
Tabletoral10 mg
Tabletoral10 mg/1
Tabletoral2.5 mg
Tabletoral20 mg/1
Tabletoral20 mg
Tabletoral5 mg/1
Tabletoral5 mg
Prices
Unit descriptionCostUnit
Prinivil 90 20 mg tablet Bottle111.71USD bottle
Prinzide 30 20-12.5 mg tablet Bottle45.99USD bottle
Prinivil 30 2.5 mg tablet Bottle22.48USD bottle
Lisinopril 100% powder21.6USD g
Zestril 40 mg tablet2.53USD tablet
Zestril 30 mg tablet2.41USD tablet
Prinivil 40 mg tablet2.23USD tablet
Zestoretic 20-25 mg tablet2.01USD tablet
Zestoretic 20-12.5 mg tablet2.0USD tablet
Prinzide 20-25 mg tablet1.98USD tablet
Zestoretic 10-12.5 mg tablet1.89USD tablet
Zestoretic 10-12.5 tablet1.75USD tablet
Lisinopril 30 mg tablet1.53USD tablet
Lisinopril 40 mg tablet1.44USD tablet
Prinzide 20-12.5 mg tablet1.38USD tablet
Prinzide 10-12.5 mg tablet1.37USD tablet
Zestril 20 mg tablet1.37USD tablet
Zestril 10 mg tablet1.33USD tablet
Zestoretic 20-25 tablet1.28USD tablet
Zestril 5 mg tablet1.28USD tablet
Zestoretic 20-12.5 tablet1.26USD tablet
Lisinopril 20 mg tablet1.09USD tablet
Prinivil 20 mg tablet1.05USD tablet
Zestril 2.5 mg tablet1.04USD tablet
Lisinopril 10 mg tablet1.01USD tablet
Prinivil 10 mg tablet1.01USD tablet
Lisinopril 5 mg tablet0.99USD tablet
Prinivil 5 mg tablet0.96USD tablet
Apo-Lisinopril 20 mg Tablet0.71USD tablet
Co Lisinopril 20 mg Tablet0.71USD tablet
Mylan-Lisinopril 20 mg Tablet0.71USD tablet
Novo-Lisinopril (Type P) 20 mg Tablet0.71USD tablet
Novo-Lisinopril (Type Z) 20 mg Tablet0.71USD tablet
Pms-Lisinopril 20 mg Tablet0.71USD tablet
Ran-Lisinopril 20 mg Tablet0.71USD tablet
Ratio-Lisinopril P 20 mg Tablet0.71USD tablet
Ratio-Lisinopril Z 20 mg Tablet0.71USD tablet
Sandoz Lisinopril 20 mg Tablet0.71USD tablet
Lisinopril 2.5 mg tablet0.65USD tablet
Apo-Lisinopril 10 mg Tablet0.59USD tablet
Co Lisinopril 10 mg Tablet0.59USD tablet
Mylan-Lisinopril 10 mg Tablet0.59USD tablet
Novo-Lisinopril (Type P) 10 mg Tablet0.59USD tablet
Novo-Lisinopril (Type Z) 10 mg Tablet0.59USD tablet
Pms-Lisinopril 10 mg Tablet0.59USD tablet
Ran-Lisinopril 10 mg Tablet0.59USD tablet
Ratio-Lisinopril P 10 mg Tablet0.59USD tablet
Ratio-Lisinopril Z 10 mg Tablet0.59USD tablet
Sandoz Lisinopril 10 mg Tablet0.59USD tablet
Apo-Lisinopril 5 mg Tablet0.49USD tablet
Co Lisinopril 5 mg Tablet0.49USD tablet
Mylan-Lisinopril 5 mg Tablet0.49USD tablet
Novo-Lisinopril (Type P) 5 mg Tablet0.49USD tablet
Novo-Lisinopril (Type Z) 5 mg Tablet0.49USD tablet
Pms-Lisinopril 5 mg Tablet0.49USD tablet
Ran-Lisinopril 5 mg Tablet0.49USD tablet
Ratio-Lisinopril P 5 mg Tablet0.49USD tablet
Ratio-Lisinopril Z 5 mg Tablet0.49USD tablet
Sandoz Lisinopril 5 mg Tablet0.49USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubility9.7E+004 mg/LMERCK INDEX (1996)
logP-1.01MERCK INDEX (1996); pH 7
pKa2.5 (at 25 °C)MERCK INDEX (1996)
Predicted Properties
PropertyValueSource
Water Solubility0.216 mg/mLALOGPS
logP-1.2ALOGPS
logP-3.1ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)3.17ChemAxon
pKa (Strongest Basic)10.21ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area132.96 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity107.37 m3·mol-1ChemAxon
Polarizability43.5 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0a4r-0194100000-d9a47a283478b88bb101View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-9040000000-8d6d4ae6ba18da11e336View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-001i-9000000000-77e20f7eb799eea58ab0View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Vincenzo Cannata, Valeriano Merli, Stefano Saguatti, “Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril.” U.S. Patent US6166217, issued September, 1972.

US6166217
General References
  1. Abdelmalek MF, Douglas DD: Lisinopril-induced isolated visceral angioedema: review of ACE-inhibitor-induced small bowel angioedema. Dig Dis Sci. 1997 Apr;42(4):847-50. [PubMed:9125659 ]
  2. Hasslacher C: Influence of the ACE inhibitor lisinopril on blood pressure, metabolism, and renal function parameter in hypertensive type II diabetic patients: a postmarketing surveillance study. J Diabetes Complications. 1996 May-Jun;10(3):136-8. [PubMed:8807458 ]
  3. Nielsen SE, Sugaya T, Tarnow L, Lajer M, Schjoedt KJ, Astrup AS, Baba T, Parving HH, Rossing P: Tubular and glomerular injury in diabetes and the impact of ACE inhibition. Diabetes Care. 2009 Sep;32(9):1684-8. doi: 10.2337/dc09-0429. Epub 2009 Jun 5. [PubMed:19502542 ]
  4. Patchett AA, Harris E, Tristram EW, Wyvratt MJ, Wu MT, Taub D, Peterson ER, Ikeler TJ, ten Broeke J, Payne LG, Ondeyka DL, Thorsett ED, Greenlee WJ, Lohr NS, Hoffsommer RD, Joshua H, Ruyle WV, Rothrock JW, Aster SD, Maycock AL, Robinson FM, Hirschmann R, Sweet CS, Ulm EH, Gross DM, Vassil TC, Stone CA: A new class of angiotensin-converting enzyme inhibitors. Nature. 1980 Nov 20;288(5788):280-3. [PubMed:6253826 ]
External Links
ATC CodesC09AA03C09BA03C09BB03C10BX07
AHFS Codes
  • 24:32.04
PDB Entries
FDA labelDownload (267 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Lisinopril.
AldesleukinThe risk or severity of adverse effects can be increased when Aldesleukin is combined with Lisinopril.
AlfuzosinAlfuzosin may increase the hypotensive activities of Lisinopril.
AliskirenAliskiren may increase the hyperkalemic activities of Lisinopril.
AllopurinolThe risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Lisinopril.
AmifostineLisinopril may increase the hypotensive activities of Amifostine.
AprotininAprotinin may decrease the antihypertensive activities of Lisinopril.
ArdeparinArdeparin may increase the hyperkalemic activities of Lisinopril.
AzathioprineLisinopril may increase the myelosuppressive activities of Azathioprine.
BrimonidineBrimonidine may increase the antihypertensive activities of Lisinopril.
ButabarbitalButabarbital may increase the hypotensive activities of Lisinopril.
ButethalButethal may increase the hypotensive activities of Lisinopril.
CanagliflozinCanagliflozin may increase the hyperkalemic activities of Lisinopril.
CiprofloxacinLisinopril may increase the arrhythmogenic activities of Ciprofloxacin.
DapoxetineDapoxetine may increase the orthostatic hypotensive activities of Lisinopril.
DiazoxideDiazoxide may increase the hypotensive activities of Lisinopril.
DrospirenoneLisinopril may increase the hyperkalemic activities of Drospirenone.
DuloxetineLisinopril may increase the orthostatic hypotensive activities of Duloxetine.
EplerenoneEplerenone may increase the hyperkalemic activities of Lisinopril.
EverolimusThe risk or severity of adverse effects can be increased when Everolimus is combined with Lisinopril.
HeparinHeparin may increase the hyperkalemic activities of Lisinopril.
HeptabarbitalHeptabarbital may increase the hypotensive activities of Lisinopril.
HexobarbitalHexobarbital may increase the hypotensive activities of Lisinopril.
IcatibantIcatibant may decrease the antihypertensive activities of Lisinopril.
InfliximabThe risk or severity of adverse effects can be increased when Lisinopril is combined with Infliximab.
IronThe risk or severity of adverse effects can be increased when Lisinopril is combined with Iron.
Iron DextranThe risk or severity of adverse effects can be increased when Lisinopril is combined with Iron Dextran.
LanthanumThe serum concentration of Lisinopril can be decreased when it is combined with Lanthanum.
LevodopaLisinopril may increase the orthostatic hypotensive activities of Levodopa.
LithiumThe serum concentration of Lithium can be increased when it is combined with Lisinopril.
MethohexitalMethohexital may increase the hypotensive activities of Lisinopril.
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Lisinopril.
MolsidomineMolsidomine may increase the hypotensive activities of Lisinopril.
MoxonidineMoxonidine may increase the hypotensive activities of Lisinopril.
NicorandilNicorandil may increase the hypotensive activities of Lisinopril.
ObinutuzumabLisinopril may increase the hypotensive activities of Obinutuzumab.
PentobarbitalPentobarbital may increase the hypotensive activities of Lisinopril.
PentoxifyllinePentoxifylline may increase the hypotensive activities of Lisinopril.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Lisinopril.
PregabalinThe risk or severity of adverse effects can be increased when Lisinopril is combined with Pregabalin.
PrimidonePrimidone may increase the hypotensive activities of Lisinopril.
QuinineQuinine may increase the hypotensive activities of Lisinopril.
RisperidoneLisinopril may increase the hypotensive activities of Risperidone.
RituximabLisinopril may increase the hypotensive activities of Rituximab.
SacubitrilThe risk or severity of adverse effects can be increased when Lisinopril is combined with Sacubitril.
SecobarbitalSecobarbital may increase the hypotensive activities of Lisinopril.
SirolimusThe risk or severity of adverse effects can be increased when Sirolimus is combined with Lisinopril.
SitagliptinThe risk or severity of adverse effects can be increased when Sitagliptin is combined with Lisinopril.
Sodium aurothiomalateThe risk or severity of adverse effects can be increased when Lisinopril is combined with Sodium aurothiomalate.
TadalafilTadalafil may increase the antihypertensive activities of Lisinopril.
TemsirolimusThe risk or severity of adverse effects can be increased when Temsirolimus is combined with Lisinopril.
TizanidineTizanidine may increase the hypotensive activities of Lisinopril.
TolvaptanTolvaptan may increase the hyperkalemic activities of Lisinopril.
TorasemideTorasemide may increase the hypotensive activities of Lisinopril.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Lisinopril.
TreprostinilTreprostinil may increase the hypotensive activities of Lisinopril.
TriamtereneTriamterene may increase the hyperkalemic activities of Lisinopril.
TrichlormethiazideTrichlormethiazide may increase the hypotensive activities of Lisinopril.
TrimethoprimTrimethoprim may increase the hyperkalemic activities of Lisinopril.
ValsartanThe risk or severity of adverse effects can be increased when Valsartan is combined with Lisinopril.
VardenafilVardenafil may increase the antihypertensive activities of Lisinopril.
YohimbineYohimbine may decrease the antihypertensive activities of Lisinopril.
Food Interactions
  • Herbs that may attenuate the antihypertensive effect of lisinopril include: bayberry, blue cohash, cayenne, ephedra, ginger, ginseng (American), kola and licorice.
  • High salt intake may attenuate the antihypertensive effect of lisinopril.
  • Lisinopril decreases the excretion of potassium. Salt substitutes containing potassium increase the risk of hyperkalemia.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Gene Name:
ACE
Uniprot ID:
P12821
Molecular Weight:
149713.675 Da
References
  1. Andujar-Sanchez M, Jara-Perez V, Camara-Artigas A: Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett. 2007 Jul 24;581(18):3449-54. Epub 2007 Jun 27. [PubMed:17618628 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Piepho RW: Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7. [PubMed:11030016 ]
  4. Song JC, White CM: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. [PubMed:11929321 ]
  5. Tellez-Sanz R, Garcia-Fuentes L, Baron C: Calorimetric analysis of lisinopril binding to angiotensin I-converting enzyme. FEBS Lett. 1998 Feb 13;423(1):75-80. [PubMed:9506845 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function.(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63.
Gene Name:
ACE2
Uniprot ID:
Q9BYF1
Molecular Weight:
92462.4 Da
References
  1. Parish RC, Miller LJ: Adverse effects of angiotensin converting enzyme (ACE) inhibitors. An update. Drug Saf. 1992 Jan-Feb;7(1):14-31. [PubMed:1536695 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  3. Piepho RW: Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm. 2000 Oct 1;57 Suppl 1:S3-7. [PubMed:11030016 ]
  4. Song JC, White CM: Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet. 2002;41(3):207-24. [PubMed:11929321 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Takara K, Kakumoto M, Tanigawara Y, Funakoshi J, Sakaeda T, Okumura K: Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. [PubMed:11895100 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Proton-dependent oligopeptide secondary active transmembrane transporter activity
Specific Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
Gene Name:
SLC15A1
Uniprot ID:
P46059
Molecular Weight:
78805.265 Da
References
  1. Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. [PubMed:15618677 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on January 08, 2014 09:42