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Identification
NamePrilocaine
Accession NumberDB00750  (APRD00180)
TypeSmall Molecule
GroupsApproved
DescriptionA local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Structure
Thumb
Synonyms
2-(Propylamino)-O-propionotoluidide
2-Methyl-alpha-propylaminopropionanilide
alpha-N-Propylamino-2-methylpropionanilide
N-(2-Methylphenyl)-2-(propylamino)propanamide
O-Methyl-2-propylaminopropionanilide
O-Methyl-alpha-propylaminopropionanilide
Prilocain
Prilocaina
Prilocaïne
Prilocaine base
Prilocainum
Propitocaine
External Identifiers
  • Astra 1512
  • L 67
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
4% Citanest Plain Dentalsolution40 mgblock/infiltrationDentsply Canada Limited2015-12-23Not applicableCanada
AgoneazekittopicalAlvix Laboratories, LLC2016-01-12Not applicableUs
Dentsply 4% Prilocaine Hydrochloride Dental Injectionsolution40 mgblock/infiltrationDentsply Canada Limited1964-12-312016-06-03Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Citanest Plaininjection, solution40 mg/mLdentalDentsply Pharmaceutical Inc.1965-11-18Not applicableUs
Prilocaine Hydrochlorideinjection, solution40 mg/mLsubcutaneousSeptodont Inc.2011-01-01Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CitanestAstraZeneca
PrilotekalGoldshield
TakiprilMeduna
XylonestAstraZeneca
Brand mixtures
NameLabellerIngredients
4% Citanest Forte Dental With Epinephrine 1:200,000Dentsply Canada Limited
Citanest ForteDentsply Pharmaceutical Inc.
Dentsply 4% Prilocaine and Epinephrine Injection 1:200,000Dentsply Canada Limited
EmlaActavis Pharma, Inc.
Emla CrmAstrazeneca Canada Inc
Emla PatchAstrazeneca Canada Inc
IV Infusion CpiPure Tek Corporation
Lidocaine 2.5% and Prilocaine 2.5% CreamWelgo, Llc
Lidocaine and PrilocaineImpax Generics
Lidocaine-prilocaine-cream BaseHumco Holding Group, Inc.
OraqixDentsply Pharmaceutical
Prilocaine HCl 4% Epineph 1:200000injNovocol Pharmaceutical Of Canada Inc
Prilocaine Hydrochloride With EpinephrineSeptodont Inc.
Relador Pak PlusAccelis Pharma
Relador Pak With Occlusive DressingAccelis Pharma
Salts
Name/CASStructureProperties
Prilocaine Hydrochloride
ThumbNot applicableDBSALT000962
Categories
UNII046O35D44R
CAS number721-50-6
WeightAverage: 220.3107
Monoisotopic: 220.157563272
Chemical FormulaC13H20N2O
InChI KeyInChIKey=MVFGUOIZUNYYSO-UHFFFAOYSA-N
InChI
InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
IUPAC Name
N-(2-methylphenyl)-2-(propylamino)propanamide
SMILES
CCCNC(C)C(=O)NC1=CC=CC=C1C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • N-arylamide
  • Aminotoluene
  • Toluene
  • Benzenoid
  • Monocyclic benzene moiety
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Secondary amine
  • Secondary aliphatic amine
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationUsed as a local anaesthetic and is often used in dentistry.
PharmacodynamicsPrilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.
Mechanism of actionPrilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein binding98%
MetabolismNot Available
Route of eliminationPrilocaine is metabolized in both the liver and the kidney and excreted via the kidney.
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Prilocaine Action PathwayDrug actionSMP00401
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9557
Blood Brain Barrier+0.9285
Caco-2 permeable+0.7888
P-glycoprotein substrateSubstrate0.6968
P-glycoprotein inhibitor INon-inhibitor0.8019
P-glycoprotein inhibitor IINon-inhibitor0.9165
Renal organic cation transporterNon-inhibitor0.895
CYP450 2C9 substrateNon-substrate0.7803
CYP450 2D6 substrateNon-substrate0.5124
CYP450 3A4 substrateNon-substrate0.5253
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9232
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6298
Ames testNon AMES toxic0.7941
CarcinogenicityNon-carcinogens0.6653
BiodegradationNot ready biodegradable0.9577
Rat acute toxicity2.1374 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9676
hERG inhibition (predictor II)Non-inhibitor0.8577
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Solutionblock/infiltration40 mg
Kittopical
Injection, solutiondental
Injection, solutiondental40 mg/mL
Solutionblock/infiltration
Patchtopical
Kit
Creamtopical
Gelperiodontal
Geltopical
Liquidblock/infiltration
Injection, solutionsubcutaneous40 mg/mL
Injection, solutionsubcutaneous
Kittopical
Prices
Unit descriptionCostUnit
Prilocaine hcl powder3.98USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6031007 No1997-04-012017-04-01Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point37-38 °CPhysProp
boiling point159-162 °C at 1.00E-01 mm HgPhysProp
water solubility541 mg/LNot Available
logP2.11HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.326 mg/mLALOGPS
logP1.87ALOGPS
logP2.68ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)13.51ChemAxon
pKa (Strongest Basic)8.82ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area41.13 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity67.86 m3·mol-1ChemAxon
Polarizability25.98 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (8.45 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US3160662
General ReferencesNot Available
External Links
ATC CodesN01BB04N01BB54
AHFS Codes
  • 72:00.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.4 KB)
Interactions
Drug Interactions
Drug
7-NitroindazoleThe risk or severity of adverse effects can be increased when Prilocaine is combined with 7-Nitroindazole.
AcepromazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Acepromazine.
AceprometazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Aceprometazine.
AcetaminophenThe risk or severity of adverse effects can be increased when Acetaminophen is combined with Prilocaine.
adipiplonThe risk or severity of adverse effects can be increased when Prilocaine is combined with adipiplon.
AgomelatineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Agomelatine.
AlfaxaloneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Alfaxalone.
AlfentanilThe risk or severity of adverse effects can be increased when Prilocaine is combined with Alfentanil.
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Alphacetylmethadol.
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Prilocaine.
AmisulprideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Amisulpride.
AmitriptylineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Amitriptyline.
AmobarbitalThe risk or severity of adverse effects can be increased when Prilocaine is combined with Amobarbital.
AmoxapineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Amoxapine.
AmperozideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Amperozide.
Amyl NitriteThe risk or severity of adverse effects can be increased when Amyl Nitrite is combined with Prilocaine.
AntipyrineThe risk or severity of adverse effects can be increased when Antipyrine is combined with Prilocaine.
AripiprazoleThe risk or severity of adverse effects can be increased when Prilocaine is combined with Aripiprazole.
ArticaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Articaine.
AsenapineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Asenapine.
AzaperoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Azaperone.
AzelastinePrilocaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Prilocaine.
BaclofenThe risk or severity of adverse effects can be increased when Prilocaine is combined with Baclofen.
BarbitalThe risk or severity of adverse effects can be increased when Prilocaine is combined with Barbital.
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Prilocaine.
Benzyl alcoholThe risk or severity of adverse effects can be increased when Prilocaine is combined with Benzyl alcohol.
BrexpiprazoleThe risk or severity of adverse effects can be increased when Prilocaine is combined with Brexpiprazole.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
BrimonidineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Brimonidine.
BromazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Bromazepam.
BrompheniramineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Brompheniramine.
BrotizolamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Brotizolam.
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Prilocaine.
BuprenorphineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Buprenorphine.
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Prilocaine.
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Prilocaine.
ButacaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Butacaine.
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Prilocaine.
ButambenThe risk or severity of adverse effects can be increased when Prilocaine is combined with Butamben.
ButethalThe risk or severity of adverse effects can be increased when Prilocaine is combined with Butethal.
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Prilocaine.
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Prilocaine.
CarbinoxamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Carbinoxamine.
CarfentanilThe risk or severity of adverse effects can be increased when Prilocaine is combined with Carfentanil.
CarisoprodolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Carisoprodol.
CelecoxibThe risk or severity of adverse effects can be increased when Celecoxib is combined with Prilocaine.
CetirizineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Cetirizine.
Chloral hydrateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chloral hydrate.
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Prilocaine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chlormezanone.
ChloroprocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chloroprocaine.
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Prilocaine.
ChlorphenamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chlorphenamine.
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Prilocaine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chlorprothixene.
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Chlorzoxazone.
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Prilocaine.
CitalopramThe risk or severity of adverse effects can be increased when Prilocaine is combined with Citalopram.
ClemastineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clemastine.
ClidiniumThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clidinium.
ClobazamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clobazam.
clomethiazoleThe risk or severity of adverse effects can be increased when Prilocaine is combined with clomethiazole.
ClomipramineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clomipramine.
ClonazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clonazepam.
ClonidineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Clonidine.
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Prilocaine.
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Prilocaine.
CocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Cocaine.
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Prilocaine.
CyclizineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Cyclizine.
CyclobenzaprineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Cyclobenzaprine.
CyproheptadineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Cyproheptadine.
DantroleneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dantrolene.
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Prilocaine.
DapoxetineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dapoxetine.
DapsoneThe risk or severity of adverse effects can be increased when Dapsone is combined with Prilocaine.
deramciclaneThe risk or severity of adverse effects can be increased when Prilocaine is combined with deramciclane.
DesfluraneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Desflurane.
DesipramineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Desipramine.
DesloratadineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Desloratadine.
DetomidineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Detomidine.
DexbrompheniramineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dexbrompheniramine.
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Prilocaine.
DextromoramideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dextromoramide.
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Prilocaine.
DezocineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dezocine.
DiazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Diazepam.
DifenoxinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Difenoxin.
DihydrocodeineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dihydrocodeine.
DihydroetorphineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dihydroetorphine.
DihydromorphineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dihydromorphine.
DimenhydrinateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dimenhydrinate.
DiphenhydramineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Diphenhydramine.
DiphenoxylateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Diphenoxylate.
DoramectinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Doramectin.
DoxepinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Doxepin.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
DoxylamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Doxylamine.
DPDPEThe risk or severity of adverse effects can be increased when Prilocaine is combined with DPDPE.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
DroperidolThe risk or severity of adverse effects can be increased when Droperidol is combined with Prilocaine.
DrotebanolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Drotebanol.
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Prilocaine.
EcgonineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ecgonine.
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Prilocaine is combined with ECGONINE METHYL ESTER.
EfavirenzThe risk or severity of adverse effects can be increased when Prilocaine is combined with Efavirenz.
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Prilocaine.
EntacaponeThe risk or severity of adverse effects can be increased when Prilocaine is combined with Entacapone.
EscitalopramThe risk or severity of adverse effects can be increased when Prilocaine is combined with Escitalopram.
EstazolamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Estazolam.
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Prilocaine.
EthanolPrilocaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Prilocaine.
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Prilocaine.
EthosuximideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ethosuximide.
EthotoinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ethotoin.
Ethyl carbamateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ethyl carbamate.
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ethyl loflazepate.
EthylmorphineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ethylmorphine.
EtidocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Etidocaine.
EtifoxineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Etifoxine.
EtizolamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Etizolam.
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Prilocaine.
EtoperidoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Etoperidone.
EtorphineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Etorphine.
EzogabineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ezogabine.
FelbamateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Felbamate.
FencamfamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fencamfamine.
FenfluramineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fenfluramine.
FentanylThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fentanyl.
FexofenadineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fexofenadine.
FlibanserinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Flibanserin.
FludiazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fludiazepam.
FlunarizineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Flunarizine.
FlunitrazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Flunitrazepam.
FluoxetineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Prilocaine.
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Prilocaine.
FluspirileneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fluspirilene.
FlutamideThe risk or severity of adverse effects can be increased when Flutamide is combined with Prilocaine.
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fluticasone Propionate.
FluvoxamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fluvoxamine.
FosphenytoinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fosphenytoin.
FospropofolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Fospropofol.
GabapentinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Gabapentin.
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Prilocaine is combined with gabapentin enacarbil.
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Prilocaine is combined with Gamma Hydroxybutyric Acid.
GlutethimideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Glutethimide.
GuanfacineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Guanfacine.
HalazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Halazepam.
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Prilocaine.
HalothaneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Halothane.
HeroinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Heroin.
HexobarbitalThe risk or severity of adverse effects can be increased when Prilocaine is combined with Hexobarbital.
HyaluronidaseThe risk or severity of adverse effects can be increased when Hyaluronidase is combined with Prilocaine.
HydrocodoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Hydrocodone.
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Prilocaine.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
HydroxyzineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Hydroxyzine.
IloperidoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Iloperidone.
ImipramineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Imipramine.
IndalpineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Indalpine.
IsofluraneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Isoflurane.
IsomethepteneThe risk or severity of adverse effects can be increased when Isometheptene is combined with Prilocaine.
Isosorbide DinitrateThe risk or severity of adverse effects can be increased when Isosorbide Dinitrate is combined with Prilocaine.
Isosorbide MononitrateThe risk or severity of adverse effects can be increased when Isosorbide Mononitrate is combined with Prilocaine.
KetamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ketamine.
KetazolamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ketazolam.
KetobemidoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ketobemidone.
LamotrigineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Lamotrigine.
LevetiracetamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Levetiracetam.
LevobupivacaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Levobupivacaine.
LevocabastineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Levocabastine.
LevocetirizineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Levocetirizine.
LevodopaThe risk or severity of adverse effects can be increased when Prilocaine is combined with Levodopa.
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Levomethadyl Acetate.
LevomilnacipranThe risk or severity of adverse effects can be increased when Prilocaine is combined with Levomilnacipran.
LevorphanolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Levorphanol.
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Prilocaine.
LithiumThe risk or severity of adverse effects can be increased when Prilocaine is combined with Lithium.
LofentanilThe risk or severity of adverse effects can be increased when Prilocaine is combined with Lofentanil.
LoratadineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Loratadine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Prilocaine.
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Prilocaine.
Lu AA21004The risk or severity of adverse effects can be increased when Prilocaine is combined with Lu AA21004.
LurasidoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Lurasidone.
MafenideThe risk or severity of adverse effects can be increased when Mafenide is combined with Prilocaine.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
Magnesium SulfateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Magnesium Sulfate.
MaprotilineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Maprotiline.
MeclizineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Meclizine.
MedetomidineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Medetomidine.
MelatoninThe risk or severity of adverse effects can be increased when Prilocaine is combined with Melatonin.
MelperoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Melperone.
MepivacaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Mepivacaine.
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Prilocaine.
MesoridazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Mesoridazine.
MetaxaloneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Metaxalone.
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Prilocaine.
Methadyl AcetateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methadyl Acetate.
MethapyrileneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methapyrilene.
MethaqualoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methaqualone.
MethocarbamolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methocarbamol.
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Prilocaine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methotrimeprazine.
MethoxyfluraneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methoxyflurane.
MethsuximideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methsuximide.
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Prilocaine is combined with Methylphenobarbital.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Prilocaine.
MetyrosinePrilocaine may increase the sedative activities of Metyrosine.
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Prilocaine.
MilnacipranThe risk or severity of adverse effects can be increased when Prilocaine is combined with Milnacipran.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
MirtazapinePrilocaine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MirtazapineThe risk or severity of adverse effects can be increased when Mirtazapine is combined with Prilocaine.
MolindoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Prilocaine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Prilocaine.
NabiloneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Nabilone.
NalbuphineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Nalbuphine.
NitrazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Nitrazepam.
Nitric OxideThe risk or severity of adverse effects can be increased when Nitric Oxide is combined with Prilocaine.
NitrofurantoinThe risk or severity of adverse effects can be increased when Nitrofurantoin is combined with Prilocaine.
NitroglycerinThe risk or severity of adverse effects can be increased when Nitroglycerin is combined with Prilocaine.
NitroprussideThe risk or severity of adverse effects can be increased when Nitroprusside is combined with Prilocaine.
Nitrous oxideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Nitrous oxide.
NormethadoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Normethadone.
NortriptylineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Nortriptyline.
OlanzapineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Olanzapine.
OlopatadineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Olopatadine.
OndansetronThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ondansetron.
OpiumThe risk or severity of adverse effects can be increased when Prilocaine is combined with Opium.
OrphenadrinePrilocaine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OrphenadrineThe risk or severity of adverse effects can be increased when Orphenadrine is combined with Prilocaine.
OsanetantThe risk or severity of adverse effects can be increased when Prilocaine is combined with Osanetant.
OxazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Oxazepam.
OxprenololThe risk or severity of adverse effects can be increased when Prilocaine is combined with Oxprenolol.
OxybuprocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Oxybuprocaine.
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Prilocaine.
OxymorphoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Oxymorphone.
PaliperidoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Paliperidone.
ParaldehydePrilocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParaldehydeThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Prilocaine.
ParoxetineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Paroxetine.
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Prilocaine.
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Prilocaine.
PerampanelThe risk or severity of adverse effects can be increased when Prilocaine is combined with Perampanel.
PerospironeThe risk or severity of adverse effects can be increased when Prilocaine is combined with Perospirone.
PerphenazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Perphenazine.
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Prilocaine.
PhenazopyridineThe risk or severity of adverse effects can be increased when Phenazopyridine is combined with Prilocaine.
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Prilocaine.
PhenoxyethanolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Phenoxyethanol.
PhenytoinThe risk or severity of adverse effects can be increased when Phenytoin is combined with Prilocaine.
PimozideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Pimozide.
PipamperoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Pipamperone.
PipotiazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Pipotiazine.
PizotifenThe risk or severity of adverse effects can be increased when Prilocaine is combined with Pizotifen.
PomalidomideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Pomalidomide.
PramipexolePrilocaine may increase the sedative activities of Pramipexole.
PramocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Pramocaine.
PrazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Prazepam.
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Prilocaine.
PrimaquineThe risk or severity of adverse effects can be increased when Primaquine is combined with Prilocaine.
PrimidoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Primidone.
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Prilocaine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Prilocaine.
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Prilocaine.
PromethazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Promethazine.
ProparacaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Proparacaine.
PropofolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Propofol.
PropoxycaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Propoxycaine.
ProtriptylineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Protriptyline.
PSD502The risk or severity of adverse effects can be increased when Prilocaine is combined with PSD502.
QuazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Quetiapine.
QuinineThe risk or severity of adverse effects can be increased when Quinine is combined with Prilocaine.
RamelteonThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ramelteon.
RemifentanilThe risk or severity of adverse effects can be increased when Prilocaine is combined with Remifentanil.
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Prilocaine.
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Prilocaine.
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Prilocaine.
RomifidineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Romifidine.
RopinirolePrilocaine may increase the sedative activities of Ropinirole.
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Prilocaine.
RotigotinePrilocaine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Prilocaine.
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Prilocaine is combined with S-Ethylisothiourea.
ScopolamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Scopolamine.
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Prilocaine.
SertindoleThe risk or severity of adverse effects can be increased when Prilocaine is combined with Sertindole.
SertralineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Sertraline.
SevofluraneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Sevoflurane.
Sodium NitriteThe risk or severity of adverse effects can be increased when Sodium Nitrite is combined with Prilocaine.
Sodium oxybateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Sodium oxybate.
StiripentolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Stiripentol.
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Prilocaine.
SulfadiazineThe risk or severity of adverse effects can be increased when Sulfadiazine is combined with Prilocaine.
SulfamethoxazoleThe risk or severity of adverse effects can be increased when Sulfamethoxazole is combined with Prilocaine.
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Prilocaine.
SuvorexantThe risk or severity of adverse effects can be increased when Prilocaine is combined with Suvorexant.
TapentadolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tapentadol.
TasimelteonThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tasimelteon.
Technetium Tc-99m tilmanoceptPrilocaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Prilocaine.
TetrabenazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tetrabenazine.
TetracaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tetracaine.
TetrodotoxinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tetrodotoxin.
ThalidomidePrilocaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThalidomideThe risk or severity of adverse effects can be increased when Thalidomide is combined with Prilocaine.
ThiamylalThe risk or severity of adverse effects can be increased when Prilocaine is combined with Thiamylal.
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Prilocaine.
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Prilocaine.
ThiothixeneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Thiothixene.
TiagabineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tiagabine.
TiletamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tiletamine.
TizanidineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tizanidine.
TolcaponeThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tolcapone.
TopiramateThe risk or severity of adverse effects can be increased when Prilocaine is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Prilocaine.
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Trans-2-Phenylcyclopropylamine.
TranylcypromineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Tranylcypromine.
TrazodoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Trazodone.
TriazolamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Triazolam.
TrifluoperazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Prilocaine.
TrimipramineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Trimipramine.
TriprolidineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Triprolidine.
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Prilocaine.
VigabatrinThe risk or severity of adverse effects can be increased when Prilocaine is combined with Vigabatrin.
VilazodoneThe risk or severity of adverse effects can be increased when Prilocaine is combined with Vilazodone.
VortioxetineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Vortioxetine.
XylazineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Xylazine.
ZaleplonThe risk or severity of adverse effects can be increased when Prilocaine is combined with Zaleplon.
ZiconotideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Ziconotide.
ZimelidineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Zimelidine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Prilocaine.
ZolazepamThe risk or severity of adverse effects can be increased when Prilocaine is combined with Zolazepam.
ZolpidemThe risk or severity of adverse effects can be increased when Zolpidem is combined with Prilocaine.
ZonisamideThe risk or severity of adverse effects can be increased when Prilocaine is combined with Zonisamide.
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Prilocaine.
ZotepineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Zotepine.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Prilocaine is combined with Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity involved in sa node cell action potential
Specific Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is respon...
Gene Name:
SCN5A
Uniprot ID:
Q14524
Molecular Weight:
226937.475 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on June 13, 2005 07:24 / Updated on September 25, 2016 02:15