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Identification
NameBrompheniramine
Accession NumberDB00835  (APRD00832)
TypeSmall Molecule
GroupsApproved
Description

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. [PubChem]

Structure
Thumb
Synonyms
[3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine
1-(P-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
2-(P-Bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine
3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine
3-(P-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
BPN
Bromfeniramina
Brompheniramin
Bromphéniramine
Brompheniraminum
External Identifiers
  • AHR 1843
  • D 721
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dimegan Inj 10mg/mlliquid10 mgDexo Sa Labs Pharms1988-12-311997-05-30Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dimetane Elixir 2mg/5mlelixir2 mgoralWhitehall Robins Inc.1993-12-311997-08-07Canada
Dimetane Tab 4mgtablet4 mgoralWhitehall Robins Inc.1957-12-312000-07-26Canada
J-tan Pdliquid1 mg/mLoralJay Mac Pharmaceuticals Llc2007-05-29Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
BromfedWockhardt USA, LLC
BromfenexEthex Corporation
DimetaneWyeth
LodraneECR Pharmaceuticals
Brand mixtures
NameLabellerIngredients
7 Select Cold and Allergy Childrens7 Eleven
Alahist DMPoly Pharmaceuticals, Inc.
Altidec AAlternative Pharmacal Corporation
Altipres-BAlternative Pharmacal Corporation
Ap-hist DMAllegis Pharmaceuticals, LLC
Assured Childrens Cold and CoughBio Pharm, Inc.
Atuss DaAber Pharmaceuticals, Llc
Auro Tap Childrens Cold and AllergyAurohealth LLC
Auromine Childrens Cold and AllergyAurohealth LLC
Balahist DM SyrupBallay Pharmaceuticals, Inc.
Bio Dtuss DmxAdvanced Generic Corporation
Bio T Pres-BAdvanced Generic Corporation
Bpm-DM-phenCintex Services, Llc
Brohist DAllegis Pharmaceuticals, LLC
Brom TappRij Pharmaceutical Corporation
Brom Tapp DMRij Pharmaceutical Corporation
Bromfed DMClinical Solutions Wholesale
Bromfeddm DMPhysicians Total Care, Inc.
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan HydrobromidePaddock Laboratories, LLC
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and DextromethorphanhydrobromideMorton Grove Pharmaceuticals, Inc.
Brompheniramine Maleate, Pseudoephedrine Hydrochloride, and Dextromethorphan HydrobromideBoca Pharmacal, LLC
BrotappSilarx Pharmaceuticals, Inc
Brotapp DM Cold and CoughSilarx Pharmaceuticals, Inc
Brotapp PE-DM Cough and Cold LiquidSilarx Pharmaceutical, Inc
Brovex PebMcr American Pharmaceuticals, Inc.
Brovex Peb DMMcr American Pharmaceuticals, Inc.
Brovex PsbMcr American Pharmaceuticals, Inc.
Brovex Psb DMMcr American Pharmaceuticals, Inc.
Careone Childrens Cold and AllergyAmerican Sales Company
Careone Childrens Cold and CoughAmerican Sales Company
Centussin DhcCenturion Labs, Llc
Childrens Cold and AllergySelect Brand Dist.
Childrens Cold and Allergy ReliefSafeway, Inc.
Childrens Cold and CoughSelect Brand Dist.
Childrens Cold and Cough ReliefFamily Dollar (FAMILY WELLNESS)
Childrens Dibromm Cold and AllergySelect Brand Dist.
Childrens Dibromm Cold and CoughFreds Inc
Childrens Dimetapp Cold and AllergyRichmond Division of Wyeth
Childrens Dimetapp Cold and CoughRichmond Division of Wyeth
Childrens Metapp DaytimeGuardian Drug Company
Childrens Wal Tap DMWalgreen Company
Childrens Wal Tap DM Cough and ColdWalgreen Company
Childrens Wal Tap Elixer Cold and AllergyWalgreens
Cold & Allergy Relief - LiqStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Cold and Allergy ChildrensMeijer Distribution Inc
Cold and CoughH E B
Cold and Cough ChildrensCVS Pharmacy
Cold and Cough DMPublix Super Markets Inc
Cold LiquidTanta Pharmaceuticals Inc
Cold Liquid Grape FlavourPharmetics (2011) Inc
Cold ReliefPerrigo International
Cold Relief DMPerrigo International
Cold SyrupJamp Pharma Corporation
Cough, Cold & Allergy ReliefStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Daytime Cold and Cough and Nighttime Cold and Congestion ChildrensTarget Corporation
Decongestant Antihistaminic SyrupPharmascience Inc
Dg Health Cold and Allergy ChildrensDolgencorp Inc
Dibromm Cold and Allergy ChildrensQUALITY CHOICE (Chain Drug Marketing Association)
Dibromm DMMajor Pharmaceuticals
Dibromm With PEMajor Pharmaceuticals
Dicel CDCentrix Pharmaceutical
DimaphenMajor Pharmaceuticals
Dimaphen DMMajor Pharmaceuticals
Dimetane DxCreekwood Pharmaceuticals Inc.
Dimetane Expectorant CPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetane Expectorant DcPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetane Expectorant LiqWhitehall Robins Inc.
Dimetane Expectorant-C SyrWhitehall Robins Inc.
Dimetane Expectorant-DC SyrWhitehall Robins Inc.
DimetappPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetapp Chewable TabletsWhitehall Robins Inc.
Dimetapp Chewables for KidsPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetapp Children's Cold & Allergy TabletsWhitehall Robins Inc.
Dimetapp Children's Cold & FeverWhitehall Robins Inc.
Dimetapp ClearWhitehall Robins Inc.
Dimetapp Cough & Cold Liqui-gels - CapWhitehall Robins Inc.
Dimetapp Cough, Cold & FluWhitehall Robins Inc.
Dimetapp DM Cough & ColdPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetapp DM ElixirWhitehall Robins Inc.
Dimetapp DM TabWhitehall Robins Inc.
Dimetapp ElixirWhitehall Robins Inc.
Dimetapp ExtentabsWhitehall Robins Inc.
Dimetapp Extra StrengthPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetapp Extra Strength DM Cough & ColdPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetapp Liqui-gels CapWhitehall Robins Inc.
Dimetapp Oral Infant Cold and Fever DropsWyeth Consumer Healthcare Inc.
Dimetapp Oral Infant Cold DropsWyeth Consumer Healthcare Inc.
Dimetapp Oral Infant DropsWhitehall Robins Inc.
Dimetapp TabWhitehall Robins Inc.
Dimetapp-CPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Dimetapp-C SyrWhitehall Robins Inc.
DM Cough and Cold LiquidTanta Pharmaceuticals Inc
DM Cough and Cold Liquid Cherry FlavourPharmetics (2011) Inc
DM Cough and Cold ReliefPharmetics (2011) Inc
DM Cough and Cold SyrupJamp Pharma Corporation
Endacof DMLarken Laboratories, Inc.
Equaline Childrens Cold and CoughSupervalu Inc
Equate Childrens Cold and CoughWal Mart Stores Inc
Extra Strength Cold LiquidTanta Pharmaceuticals Inc
Extra Strength Cold SyrupJamp Pharma Corporation
Extra Strength DM Cough and Cold LiquidTanta Pharmaceuticals Inc
Extra Strength DM Cough and Cold SyrupJamp Pharma Corporation
Glenmax PebGlendale Inc
Glenmax Peb DMGlendale Inc
Glenmax Peb DM ForteGlendale Inc
Good Neighbor Pharmacy Cold and Allergy ChildrensAmerisource Bergen
Good Neighbor Pharmacy Cold and CoughAmerisource Bergen
Good Sense Childrens Cold and AllergyL. Perrigo Company
Good Sense Childrens Cold and Cough ElixirL Perrigo Company
Health Mart Cold and Allergy ChildrensMc Kesson
Health Mart Cold and Cough ChildrensMc Kesson
Healthy Accents Childrens Cold and CoughDZA Brands LLC
Healthy Accents Cold and Allergy ChildrensDZA Brands LLC
Healthy Accents Cold and Cough DMDZA Brands LLC
J-cof DhcJay Mac Pharmaceuticals
J-tan D PdJay Mac Pharmaceuticals Llc
Kids Cold Chewable TabletsTanta Pharmaceuticals Inc
Leader Childrens Cold and AllergyCardinal Health
Leader Childrens Cold and CoughCardinal Health
Lodrane DECR Pharmaceuticals
Lohist DMLarken Laboratories, Inc.
Lohist PebLarken Laboratories, Inc.
Lohist Peb DMLarken Laboratories, Inc.
M-end PER.A. Mc Neil Company
M-end WcR.A. Mc Neil Company
Mar-cof BPMarnel Pharmaceutcals, Inc.
Neo DMLaser Pharmaceuticals Llc
Niva-hist DMNivagen Pharmaceuticals, Inc.
Oral Infant Cold DropsTanta Pharmaceuticals Inc
Pharmetapp ElixirTherapex Division De E Z Em Canada Inc
PluratussCreekwood Pharmaceutical, Inc.
Poly-tussin AcPoly Pharmaceuticals, Inc.
Presgen BKramer Novis
Q Tapp Cold and AllergyQualitest Pharmaceuticals
Q Tapp Cold and CoughQualitest Pharmaceuticals
Q-tappQualitest Pharmaceuticals
Q-tapp DM ElixirQualitest Pharmaceuticals
Relcof DMBurel Pharmaceuticals, Inc
Relhist BPBurel Pharmaceuticals, Inc
Robitussin Children's ColdPfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Robitussin Children's Cough & Cold BedtimePfizer Consumer Healthcare A Division Of Pfizer Canada Inc
Rompe Pecho Sf FluEfficient Laboratories Inc
Ru-hist DAllegis Pharmaceuticals, LLC
Runny Nose and CoughAccudial Pharmaceutical, Inc.
Rx Act Cold and Allergy ChildrensH E B
RydexCenturion Labs
Rynex DMEDWARDS PHARMACEUTICALS, INC.
Rynex PEEDWARDS PHARMACEUTICALS, INC.
Rynex PseEDWARDS PHARMACEUTICALS, INC.
Shoprite Childrens Cold and AllergyWakefern Food Corporation
Shoprite Childrens Cold and CoughWakefern Food Corporation
Signature Care Childrens Cold and CoughSafeway
Smart Sense Cold and Allergy ChildrensKmart Corporation
Smart Sense Cold and CoughKmart Corporation
StaflexMagna Pharmaceuticals, Inc.
Sunmark Cold and Allergy ChildrensMc Kesson
Sunmark Cold and Cough DM ChildrensMc Kesson
Tantapp ElixirTanta Pharmaceuticals Inc
Topcare Childrens Cold and Allergy ElixerTopco Associates LLC
Topcare Childrens Cold and Cough ElixirTopco Associates LLC
Triaminic Cold and AllergyNovartis Consumer Health, Inc.
Tussi Pres BKramer Novis
Up and Up Childrens Cold and CoughTarget Corporation
Vazobid-PDWraser Pharmaceuticals
Wal Tap Elixir ChildrensWalgreen Company
Salts
Name/CASStructureProperties
Brompheniramine maleate
ThumbNot applicableDBSALT000940
Categories
UNIIH57G17P2FN
CAS number86-22-6
WeightAverage: 319.239
Monoisotopic: 318.073161265
Chemical FormulaC16H19BrN2
InChI KeyInChIKey=ZDIGNSYAACHWNL-UHFFFAOYSA-N
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
IUPAC Name
[3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
SMILES
CN(C)CCC(C1=CC=C(Br)C=C1)C1=CC=CC=N1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as pheniramines. These are compounds containing a pheniramine moiety, which is structurally characterized by the presence of a 2-benzylpyridine linked to an dimethyl(propyl)amine to form a dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine skeleton.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPyridines and derivatives
Sub ClassPheniramines
Direct ParentPheniramines
Alternative Parents
Substituents
  • Pheniramine
  • Phenylpropylamine
  • Aralkylamine
  • Halobenzene
  • Bromobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl bromide
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organobromide
  • Organohalogen compound
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.
PharmacodynamicsBrompheniramine is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine. In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Brompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Mechanism of actionBrompheniramine works by acting as an antagonist of the H1 histamine receptors. It also functions as a moderately effective anticholingeric agent, likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.
Related Articles
AbsorptionAntihistamines are well absorbed from the gastrointestinal tract after oral administration.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic (cytochrome P-450 system), some renal.

Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityOral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9648
Blood Brain Barrier+0.9576
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.6242
P-glycoprotein inhibitor INon-inhibitor0.8782
P-glycoprotein inhibitor IINon-inhibitor0.93
Renal organic cation transporterInhibitor0.7955
CYP450 2C9 substrateNon-substrate0.8345
CYP450 2D6 substrateSubstrate0.8346
CYP450 3A4 substrateSubstrate0.5898
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8932
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8398
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7748
Ames testNon AMES toxic0.9351
CarcinogenicityNon-carcinogens0.9349
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.0758 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9121
hERG inhibition (predictor II)Inhibitor0.7207
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Alpharma us pharmaceuticals division
  • Kv pharmaceutical co
  • Pharmaceutical assoc inc div beach products
  • Usl pharma inc
  • Watson laboratories inc
  • Wyeth ayerst laboratories
  • Wyeth consumer healthcare
  • Barr laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Newtron pharmaceuticals inc
  • Nexgen pharma inc
  • Par pharmaceutical inc
  • Pioneer pharmaceuticals inc
  • Sandoz inc
  • Vitarine pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
Tablet, coatedoral
Tablet, chewableoral
Liquidoral
Kit
Liquid10 mg
Elixiroral2 mg
Tabletoral4 mg
Tablet (chewable)oral
Tablet (extended-release)oral
Dropsoral
Solutionoral
Elixiroral
Liquidoral1 mg/mL
Capsuleoral
Tabletoral
Syruporal
Prices
Unit descriptionCostUnit
Brompheniramine maleate powder9.83USD g
Brovex ct 12 mg tablet chew1.58USD tablet
Brompheniramine 12 mg tablet chew1.42USD tablet
Bromfenex-pd capsule sa0.56USD capsule
Bromfed-dm cough syrup0.21USD ml
Brom-pseud-dm syrup0.14USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point< 25 °CPhysProp
boiling point149.5 °C at 5.00E-01 mm HgPhysProp
water solubilityFreely soluble (maleate salt)Not Available
logP3.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0127 mg/mLALOGPS
logP3.63ALOGPS
logP3.75ChemAxon
logS-4.4ALOGPS
pKa (Strongest Basic)9.48ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area16.13 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity83.67 m3·mol-1ChemAxon
Polarizability32.08 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated)splash10-014i-4954000000-f0a4889ab8cd0d5dcaccView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated)splash10-00di-0090000000-02a74d4d4927d8e443aaView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated)splash10-014i-0920000000-ad3d20cb0f1b7362fbc3View in MoNA
MSMass Spectrum (Electron Ionization)splash10-0002-5490000000-9c3b804de0b552198b85View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

Sperber, N., Papa, D. and Schwenk, E.; US. Patent 2,567,245; September 11, 1951; assigned
to Schering Corporation.
Sperber, N., Papa, D. and Schwenk, E.; U.S. Patent 2,676,964: April 27,1954; assigned to
Schering Corporation.

General ReferencesNot Available
External Links
ATC CodesR06AB51R06AB01
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (73.1 KB)
Interactions
Drug Interactions
Drug
AclidiniumAclidinium may increase the anticholinergic activities of Brompheniramine.
AmphetamineAmphetamine may decrease the sedative activities of Brompheniramine.
AzelastineBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Brompheniramine.
BenzphetamineBenzphetamine may decrease the sedative activities of Brompheniramine.
Benzylpenicilloyl PolylysineBrompheniramine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BetahistineThe therapeutic efficacy of Betahistine can be decreased when used in combination with Brompheniramine.
Botulinum Toxin Type ABrompheniramine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BBrompheniramine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
BuprenorphineBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
CathinoneCathinone may decrease the sedative activities of Brompheniramine.
CimetropiumBrompheniramine may increase the anticholinergic activities of Cimetropium Bromide.
DextroamphetamineDextroamphetamine may decrease the sedative activities of Brompheniramine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
EluxadolineBrompheniramine may increase the activities of Eluxadoline.
EthanolBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Glucagon recombinant.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Brompheniramine.
HydrocodoneBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Brompheniramine.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Brompheniramine.
LisdexamfetamineLisdexamfetamine may decrease the sedative activities of Brompheniramine.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Brompheniramine.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
MethamphetamineMethamphetamine may decrease the sedative activities of Brompheniramine.
MethotrimeprazineBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetyrosineBrompheniramine may increase the sedative activities of Metyrosine.
MianserinMianserin may increase the anticholinergic activities of Brompheniramine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
MirabegronThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Mirabegron.
MirtazapineBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MorphineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
OrphenadrineBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
ParaldehydeBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Paroxetine.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
PhendimetrazinePhendimetrazine may decrease the sedative activities of Brompheniramine.
PhenterminePhentermine may decrease the sedative activities of Brompheniramine.
Potassium ChlorideBrompheniramine may increase the ulcerogenic activities of Potassium Chloride.
PramipexoleBrompheniramine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Brompheniramine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Brompheniramine.
RamosetronBrompheniramine may increase the activities of Ramosetron.
RopiniroleBrompheniramine may increase the sedative activities of Ropinirole.
RotigotineBrompheniramine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Brompheniramine.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Brompheniramine.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Brompheniramine.
SuvorexantBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Brompheniramine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
ThalidomideBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
TiotropiumBrompheniramine may increase the anticholinergic activities of Tiotropium.
TopiramateThe risk or severity of adverse effects can be increased when Brompheniramine is combined with Topiramate.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Brompheniramine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Brompheniramine.
ZolpidemBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Avoid alcohol.
  • Take with food.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Histamine receptor activity
Specific Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Gene Name:
HRH1
Uniprot ID:
P35367
Molecular Weight:
55783.61 Da
References
  1. Bokesoy TA, Onaran HO: Atypical Schild plots with histamine H1 receptor agonists and antagonists in the rabbit aorta. Eur J Pharmacol. 1991 May 2;197(1):49-56. [PubMed:1680053 ]
  2. Onaran HO, Bokesoy TA: Kinetics of antagonism at histamine-H1 receptors in isolated rabbit arteries. Naunyn Schmiedebergs Arch Pharmacol. 1990 Apr;341(4):316-23. [PubMed:1970615 ]
  3. Yanni JM, Stephens DJ, Parnell DW, Spellman JM: Preclinical efficacy of emedastine, a potent, selective histamine H1 antagonist for topical ocular use. J Ocul Pharmacol. 1994 Winter;10(4):665-75. [PubMed:7714410 ]
  4. Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [PubMed:7855217 ]
  5. Yasuda SU, Yasuda RP: Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [PubMed:10212017 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Phosphatidylinositol phospholipase c activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM1
Uniprot ID:
P11229
Molecular Weight:
51420.375 Da
References
  1. Yasuda SU, Yasuda RP: Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [PubMed:10212017 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
G-protein coupled acetylcholine receptor activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then trigge...
Gene Name:
CHRM2
Uniprot ID:
P08172
Molecular Weight:
51714.605 Da
References
  1. Yasuda SU, Yasuda RP: Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [PubMed:10212017 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Receptor activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM3
Uniprot ID:
P20309
Molecular Weight:
66127.445 Da
References
  1. Yasuda SU, Yasuda RP: Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [PubMed:10212017 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Guanyl-nucleotide exchange factor activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Gene Name:
CHRM4
Uniprot ID:
P08173
Molecular Weight:
53048.65 Da
References
  1. Yasuda SU, Yasuda RP: Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [PubMed:10212017 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
antagonist
General Function:
Phosphatidylinositol phospholipase c activity
Specific Function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM5
Uniprot ID:
P08912
Molecular Weight:
60073.205 Da
References
  1. Yasuda SU, Yasuda RP: Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [PubMed:10212017 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23