You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameBenzylpenicilloyl Polylysine
Accession NumberDB00895  (APRD00822)
TypeSmall Molecule
GroupsApproved
Description

Benzylpenicilloyl Polylysine is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects.

Structure
Thumb
Synonyms
Benzyl penicilloyl-polylysine
Benzylpenicilloyl G polylysine
Benzylpenicilloyl-polylysine
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Pre-peninjection60 umol/.25mLintradermal; subcutaneousAller Quest Llc1974-07-25Not applicableUs
Pre-pensolution0.000060 mintradermalAlk Abello Inc1975-12-31Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
CategoriesNot Available
UNII76479814OY
CAS number31855-75-1
WeightAverage: 626.765
Monoisotopic: 626.309783168
Chemical FormulaC28H46N6O8S
InChI KeyInChIKey=IMPVZRLKKKXMKQ-SGDOCVTFSA-N
InChI
InChI=1S/C22H32N4O6S.C6H14N2O2/c1-22(2)17(21(31)32)26-19(33-22)16(25-15(27)12-13-8-4-3-5-9-13)18(28)24-11-7-6-10-14(23)20(29)30;7-4-2-1-3-5(8)6(9)10/h3-5,8-9,14,16-17,19,26H,6-7,10-12,23H2,1-2H3,(H,24,28)(H,25,27)(H,29,30)(H,31,32);5H,1-4,7-8H2,(H,9,10)/t14-,16?,17+,19-;5-/m11/s1
IUPAC Name
SMILES
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentN-acyl-alpha amino acids and derivatives
Alternative Parents
Substituents
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid amide
  • Beta amino acid or derivatives
  • D-alpha-amino acid
  • Phenylacetamide
  • Alpha-amino acid
  • Medium-chain fatty acid
  • Heterocyclic fatty acid
  • Amino fatty acid
  • Fatty acyl
  • Fatty acid
  • Benzenoid
  • Dicarboxylic acid or derivatives
  • Monocyclic benzene moiety
  • Thiazolidine
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Dialkylthioether
  • Hemithioaminal
  • Thioether
  • Secondary amine
  • Secondary aliphatic amine
  • Carboxylic acid
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
  • Aliphatic acyclic compound
Molecular FrameworkNot Available
External Descriptors
Pharmacology
IndicationFor use as a adjunct in assessing the risk of administering penicillin (benzylpenicillin or penicillin G).
PharmacodynamicsBenylpenicilloyl polylysine is penicilloyl bound to polylysine and is considered to be the major determinant of penicillin metabolism; it is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. If skin testing using benzylpenicilloyl and penicillin G (as the sole source of minor determinants) is negative, approximately 97% of patients with a negative skin test will tolerate penicillin.
Mechanism of actionThe skin test for penicillin demonstrates the presence or absence of specific IgE antibodies to major and minor penicillin determinants. IgE antibodies to major determinants can be detected by using benzylpenicilloyl polylysine. A penicillin skin test predicts only the presence of IgE antibodies for the major or minor penicillin determinants at the time of application and does not predict the future development of IgE-mediated reactions during subsequent courses of penicillin. Benzylpenicilloyl polylysine reacts specifically with penicilloyl skin sensitizing antibodies (reagins) to produce immediate wheal and flare reactions which may reflect increased risk of allergic reactions to subsequent penicillin therapy.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicitySymptoms of overdose include urticaria, generalized pruritus, local swelling, generalized flushing, anaphylaxis, bronchospasm, fainting and maculopapular eruption.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Allerquest llc
Packagers
Dosage forms
FormRouteStrength
Injectionintradermal; subcutaneous60 umol/.25mL
Solutionintradermal0.000060 m
Prices
Unit descriptionCostUnit
Pre-pen ampul72.0USD ampul
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP-0.8Not Available
Predicted Properties
PropertyValueSource
logP-3.8ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count6ChemAxon
Polar Surface Area170.85 Å2ChemAxon
Rotatable Bond Count17ChemAxon
Refractivity122.22 m3·mol-1ChemAxon
Polarizability50.05 Å3ChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS Codes
  • 36:30.00
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
AzelastineAzelastine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
BrompheniramineBrompheniramine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
CarbinoxamineCarbinoxamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
CetirizineCetirizine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
ChlorphenamineChlorphenamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
ClemastineClemastine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
CyclizineCyclizine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
CyproheptadineCyproheptadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
DesloratadineDesloratadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
Dexchlorpheniramine maleateDexchlorpheniramine maleate may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
DimenhydrinateDimenhydrinate may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
DiphenhydramineDiphenhydramine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
DopamineDopamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
DoxylamineDoxylamine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
EphedrineEphedrine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
EpinephrineEpinephrine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
FexofenadineFexofenadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
HydroxyzineHydroxyzine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
LevocetirizineLevocetirizine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
LoratadineLoratadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
MeclizineMeclizine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
MidodrineMidodrine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
NorepinephrineNorepinephrine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
OlopatadineOlopatadine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
PhenylephrinePhenylephrine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
PizotifenPizotifen may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
PseudoephedrinePseudoephedrine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
TriprolidineTriprolidine may decrease effectiveness of Benzylpenicilloyl Polylysine as a diagnostic agent.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Igg binding
Specific Function:
Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.
Gene Name:
FCER1G
Uniprot ID:
P30273
Molecular Weight:
9667.355 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chandra RK, Joglekar SA, Tomas E: Penicillin allergy: anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin. Arch Dis Child. 1980 Nov;55(11):857-60. [PubMed:7436456 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Ige receptor activity
Specific Function:
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
Gene Name:
FCER1A
Uniprot ID:
P12319
Molecular Weight:
29595.67 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Chandra RK, Joglekar SA, Tomas E: Penicillin allergy: anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin. Arch Dis Child. 1980 Nov;55(11):857-60. [PubMed:7436456 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on May 01, 2016 15:29