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Identification
NameSalbutamol
Accession NumberDB01001  (APRD00553)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma.

Structure
Thumb
Synonyms
Albuterol
Levalbuterol
Proventil
Salbutamol
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Airomirmetered-dose aerosol100 mcginhalationValeant Canada Lp Valeant Canada S.E.C.1998-08-13Not applicableCanada
Albuterol Sulfatesolution1.5 mg/3mLrespiratory (inhalation)Mylan Pharmaceuticals Inc.2009-10-30Not applicableUs
Albuterol Sulfatesolution.75 mg/3mLrespiratory (inhalation)Mylan Pharmaceuticals Inc.2009-10-30Not applicableUs
Asmavent Nebules P.F.liquid2.5 mginhalationTechnilab Pharma Inc.1997-06-272001-09-05Canada
Asmavent Respirator Solution Inh 5mg/mlsolution5 mginhalationTechnilab Pharma Inc.1993-12-312005-08-05Canada
Bci Salbutamol Inhalation Solutionsolution2 mginhalationBaker Cummins IncNot applicableNot applicableCanada
Bci Salbutamol Inhalation Solutionsolution1 mginhalationBaker Cummins Inc2005-07-042006-10-03Canada
Dom-salbutamol Respirator Solution-1mg/mlsolution1 mginhalationDominion Pharmacal1997-05-16Not applicableCanada
Levalbuterol Hydrochloridesolution.31 mg/3mLrespiratory (inhalation)Watson Laboratories, Inc.2012-08-202015-12-29Us
Levalbuterol Hydrochloridesolution.31 mg/3mLrespiratory (inhalation)Prasco Laboratories2012-08-20Not applicableUs
Levalbuterol Hydrochloridesolution.63 mg/3mLrespiratory (inhalation)Watson Laboratories, Inc.2012-08-202015-12-29Us
Levalbuterol Hydrochloridesolution1.25 mg/3mLrespiratory (inhalation)Ritedose Pharmaceuticals, LLC2012-12-01Not applicableUs
Levalbuterol Hydrochloridesolution.63 mg/3mLrespiratory (inhalation)Ritedose Pharmaceuticals, LLC2012-12-01Not applicableUs
Levalbuterol Hydrochloridesolution1.25 mg/3mLrespiratory (inhalation)Prasco Laboratories2012-08-20Not applicableUs
Levalbuterol Hydrochloridesolution.63 mg/3mLrespiratory (inhalation)Prasco Laboratories2012-08-20Not applicableUs
Levalbuterol Hydrochloridesolution1.25 mg/3mLrespiratory (inhalation)Watson Laboratories, Inc.2012-08-202015-12-29Us
Med Salbutamol Inhalation Solution 1mg/mlsolution1 mginhalationMedican Pharma Incorporated1994-12-312011-03-29Canada
Mylan-salbutamol Respirator Solutionsolution5 mginhalationMylan Pharmaceuticals Ulc1997-11-262012-10-19Canada
Novo-salbutamol HFAmetered-dose aerosol100 mcginhalationTeva Canada Limited2009-12-31Not applicableCanada
Novo-salmol Inhaler 100mcg/aemmetered-dose aerosol100 mcgoralNovopharm Limited1991-12-312005-08-10Canada
Novo-salmol Tab 2mgtablet2 mgoralNovopharm Limited1984-12-312005-08-10Canada
Novo-salmol Tab 4mgtablet4 mgoralNovopharm Limited1984-12-312005-08-10Canada
Nu-salbutamol - Tab 2mgtablet2 mgoralNu Pharm Inc1995-12-312012-09-04Canada
Nu-salbutamol - Tab 4mgtablet4 mgoralNu Pharm Inc1995-12-312012-09-04Canada
Nu-salbutamol Plastic Ampules 2 mg/mlsolution2 mginhalationNu Pharm Inc1997-12-032012-09-04Canada
Nu-salbutamol Plastic Ampules 1 mg/mlsolution1 mginhalationNu Pharm Inc1997-12-032012-09-04Canada
PHL-salbutamol Oral Liquidsolution0.4 mgoralPharmel Inc2004-12-09Not applicableCanada
PHL-salbutamol Respirator Solutionsolution5 mginhalation; oralPharmel IncNot applicableNot applicableCanada
PHL-salbutamol Respirator Solutionsolution2 mginhalationPharmel Inc1998-02-16Not applicableCanada
PHL-salbutamol Respirator Solutionsolution1 mginhalationPharmel Inc1998-02-16Not applicableCanada
PHL-salbutamol Respirator Solutionsolution0.5 mginhalationPharmel Inc1998-02-16Not applicableCanada
PMS-salbutamolsolution0.5 mginhalationPharmascience Inc1996-12-31Not applicableCanada
PMS-salbutamolsolution5 mginhalation; oralPharmascience Inc1994-12-31Not applicableCanada
PMS-salbutamolsolution1 mginhalationPharmascience Inc1996-12-31Not applicableCanada
PMS-salbutamolsolution2 mginhalationPharmascience Inc1996-12-31Not applicableCanada
PMS-salbutamol Oral Liquidsolution0.4 mgoralPharmascience Inc2003-05-28Not applicableCanada
Proair HFAaerosol, metered90 ug/1respiratory (inhalation)Teva Respiratory, LLC2012-12-03Not applicableUs
Proair HFAaerosol, metered90 ug/1respiratory (inhalation)TYA Pharmaceuticals2012-12-03Not applicableUs
Proair HFAaerosol, metered90 ug/1respiratory (inhalation)Preferred Pharmaceuticals, Inc2012-02-13Not applicableUs
Proair HFAaerosol, metered90 ug/1respiratory (inhalation)Rebel Distributors Corp1981-01-01Not applicableUs
Proair HFAaerosol, metered90 ug/1respiratory (inhalation)Proficient Rx LP2012-12-03Not applicableUs
Proair HFAaerosol, metered90 ug/1respiratory (inhalation)Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-03-21Not applicableUs
Proair Respiclickpowder, metered90 ug/1respiratory (inhalation)Teva Respiratory, LLC2015-04-27Not applicableUs
Proairhfa HFAaerosol, metered90 ug/1respiratory (inhalation)H.J. Harkins Company, Inc.2004-12-01Not applicableUs
Proairhfa HFAaerosol, metered90 ug/1respiratory (inhalation)REMEDYREPACK INC.2013-06-13Not applicableUs
Proairhfa HFAaerosol, metered90 ug/1respiratory (inhalation)REMEDYREPACK INC.2013-06-04Not applicableUs
Proventil HFAaerosol, metered108 ug/1respiratory (inhalation)Merck Sharp & Dohme Corp.2001-10-01Not applicableUs
Proventil HFAaerosol, metered108 ug/1respiratory (inhalation)Lake Erie Medical DBA Quality Care Products LLC2001-10-01Not applicableUs
Proventil HFAaerosol, metered108 ug/1respiratory (inhalation)Physicians Total Care, Inc.2009-07-17Not applicableUs
Proventil HFAaerosol, metered108 ug/1respiratory (inhalation)Rebel Distributors Corp.2001-10-01Not applicableUs
Ratio-salbutamolmetered-dose aerosol100 mcginhalationRatiopharm Inc Division Of Teva Canada Limited1989-12-312009-07-17Canada
Ratio-salbutamolsolution2 mginhalationTeva Canada Limited2000-02-29Not applicableCanada
Ratio-salbutamolsolution0.5 mginhalationTeva Canada Limited2000-02-29Not applicableCanada
Ratio-salbutamolsolution1 mginhalationTeva Canada Limited1993-12-31Not applicableCanada
Ratio-salbutamolsolution5 mginhalationTeva Canada Limited1989-12-31Not applicableCanada
Ratio-salbutamol HFAmetered-dose aerosol100 mcginhalationRatiopharm Inc Division Of Teva Canada Limited2001-11-092010-08-02Canada
Sabulin Inhaler 100mcg/metered Dose Aerosolmetered-dose aerosol100 mcginhalationGenpharm Ulc1989-12-312004-07-30Canada
Salbu-2 - Tab 2mgtablet2 mgoralPro Doc Limitee1996-12-312003-07-31Canada
Salbu-4 - Tab 4mgtablet4 mgoralPro Doc Limitee1996-12-062003-07-31Canada
Salbutamol HFAmetered-dose aerosol100 mcginhalationSanis Health Inc2014-02-13Not applicableCanada
Salbutamol Inhalation Solutionsolution2 mginhalationIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Salbutamol Inhalation Solutionsolution1 mginhalationIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Salbutamol Inhalation Solution P.F.-1mg/mlliquid1 mginhalationBdh Inc.1997-07-162000-08-03Canada
Salbutamol Nebuamp 0.05%liquid0.05 %inhalationAstrazeneca Canada Inc1996-10-312001-07-23Canada
Salbutamol Nebuamp 0.1%liquid0.1 %inhalationAstrazeneca Canada Inc1996-10-312002-07-30Canada
Salbutamol Nebuamp 0.2%liquid0.2 %inhalationAstrazeneca Canada Inc1996-10-312001-07-23Canada
Sandoz Salbutamolsolution5 mginhalationSandoz Canada Incorporated1995-12-31Not applicableCanada
Teva-salbutamol Sterinebs P.F.solution2 mginhalationTeva Canada Limited1995-12-31Not applicableCanada
Teva-salbutamol Sterinebs P.F.solution1 mginhalationTeva Canada Limited1992-12-31Not applicableCanada
Ventodisk 200mcgpowder200 mcginhalationGlaxosmithkline Inc1997-06-112007-04-03Canada
Ventodisk 400mcgpowder400 mcginhalationGlaxosmithkline Inc1997-06-022007-04-03Canada
Ventodisk Pwr 200mcg/blisterpowder200 mcginhalationGlaxo Canada Inc1989-12-311998-07-30Canada
Ventodisk Pwr 400mcg/blisterpowder400 mcginhalationGlaxo Canada Inc1989-12-311998-07-30Canada
Ventolin Diskuspowder200 mcginhalationGlaxosmithkline Inc2001-01-02Not applicableCanada
Ventolin HFAaerosol, metered90 ug/1respiratory (inhalation)Clinical Solutions Wholesale2006-06-09Not applicableUs
Ventolin HFAaerosol, metered108 ug/1respiratory (inhalation)H.J. Harkins Company, Inc.2006-06-09Not applicableUs
Ventolin HFAmetered-dose aerosol100 mcginhalationGlaxosmithkline Inc2001-11-22Not applicableCanada
Ventolin HFAaerosol, metered108 ug/1respiratory (inhalation)Physicians Total Care, Inc.2009-11-11Not applicableUs
Ventolin HFAaerosol, metered108 ug/1respiratory (inhalation)Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC2006-06-09Not applicableUs
Ventolin HFAaerosol, metered108 ug/1respiratory (inhalation)STAT Rx USA LLC2006-06-09Not applicableUs
Ventolin HFAaerosol, metered90 ug/1respiratory (inhalation)Preferred Pharmaceuticals, Inc.2013-10-10Not applicableUs
Ventolin HFAaerosol, metered108 ug/1respiratory (inhalation)Dispensing Solutions Inc.2009-07-22Not applicableUs
Ventolin HFAaerosol, metered90 ug/1respiratory (inhalation)Unit Dose Services2006-06-09Not applicableUs
Ventolin HFAaerosol, metered90 ug/1respiratory (inhalation)Glaxo Smith Kline Llc2006-06-09Not applicableUs
Ventolin HFAaerosol, metered90 ug/1respiratory (inhalation)Proficient Rx LP2006-06-09Not applicableUs
Ventolin I.M. Injection 0.5mg Salbutamol In 1 Ml (500mcg/ml)solution0.5 mgintramuscularGlaxosmithkline Inc2000-05-022007-04-19Canada
Ventolin I.V. Bolus Injection 0.25mg Salbutamol In 5ml (50mcg/ml)solution0.25 mgintravenousGlaxosmithkline Inc1999-09-282002-01-29Canada
Ventolin I.V. Infusion Solution 5.0mg Salbutamol In 5ml (1000mcg/ml)solution1 mgintravenousGlaxosmithkline Inc1999-05-24Not applicableCanada
Ventolin Im Inj 0.5mg/mlliquid.5 mgintramuscularGlaxo Canada Inc1992-12-312000-08-02Canada
Ventolin Inhalermetered-dose aerosol100 mcginhalationGlaxosmithkline Inc1997-09-302003-01-22Canada
Ventolin Inhaler 100mcg/aemmetered-dose aerosol100 mcginhalationGlaxo Canada Inc1972-12-311998-07-30Canada
Ventolin Injection Liq IV 5mg/5mlliquid1 mgintravenousGlaxo Canada Inc1994-12-312000-08-02Canada
Ventolin IV Bolus Inj 0.05mg/mlliquid.25 mgintravenousGlaxo Canada Inc1992-12-312000-08-02Canada
Ventolin Nebules P.F. - 2.5mg/2.5mlsolution2.5 mginhalationGlaxosmithkline Inc2000-05-21Not applicableCanada
Ventolin Nebules P.F. - 5mg/2.5mlsolution5 mginhalationGlaxosmithkline Inc2000-10-02Not applicableCanada
Ventolin Nebules P.F. Liq Inh 1.25mg/2.5mlliquid1.25 mginhalationGlaxo Canada Inc1993-12-312002-11-05Canada
Ventolin Nebules P.F. Sol 2.5mg/2.5mlliquid2.5 mginhalationGlaxo Canada Inc1991-12-312000-08-02Canada
Ventolin Nebules P.F.- 1.25mg/2.5mlsolution1.25 mginhalationGlaxosmithkline Inc2002-06-122005-08-04Canada
Ventolin Nebules PF Sol 5mg/2.5mlliquid5 mginhalationGlaxo Canada Inc1992-12-312001-08-01Canada
Ventolin Oral Liquidliquid0.4 mgoralGlaxosmithkline Inc1998-12-012009-01-19Canada
Ventolin Oral Liquid 0.4mg/mlliquid.4 mgoralGlaxo Canada Inc1993-12-311999-08-12Canada
Ventolin Respirator Solutionsolution5 mginhalationGlaxosmithkline Inc1998-12-01Not applicableCanada
Ventolin Respirator Solution 5mg/mlsolution5 mginhalationGlaxo Canada Inc1993-12-311999-08-12Canada
Ventolin Rotacapspowder400 mcginhalationGlaxosmithkline Inc1998-03-302002-01-29Canada
Ventolin Rotacapspowder200 mcginhalationGlaxosmithkline Inc1997-11-242002-01-29Canada
Ventolin Rotacaps 200mcgcapsule200 mcginhalationGlaxo Canada Inc1993-12-311998-07-30Canada
Ventolin Rotacaps 400mcgcapsule400 mcginhalationGlaxo Canada Inc1993-12-311998-07-30Canada
Ventolin Tab 4mgtablet4 mgoralGlaxo Canada Inc1993-12-311996-09-10Canada
Ventolinhfa HFAaerosol, metered90 ug/1respiratory (inhalation)REMEDYREPACK INC.2015-08-25Not applicableUs
Ventolinhfa HFAaerosol, metered90 ug/1respiratory (inhalation)REMEDYREPACK INC.2014-01-30Not applicableUs
Ventolinhfa HFAaerosol, metered90 ug/1respiratory (inhalation)REMEDYREPACK INC.2013-06-10Not applicableUs
Ventolinhfa HFAaerosol, metered108 ug/1respiratory (inhalation)Rebel Distributors Corp.2006-06-09Not applicableUs
Xopenexsolution1.25 mg/3mLrespiratory (inhalation)Akorn, Inc.2015-02-27Not applicableUs
Xopenexsolution.63 mg/3mLrespiratory (inhalation)Physicians Total Care, Inc.2000-12-18Not applicableUs
Xopenexsolution1.25 mg/3mLrespiratory (inhalation)REMEDYREPACK INC.2013-06-13Not applicableUs
Xopenexsolution.63 mg/3mLrespiratory (inhalation)Akorn, Inc.2015-02-27Not applicableUs
Xopenexsolution, concentrate1.25 mg/.5mLrespiratory (inhalation)Sunovion Pharmaceuticals Inc.2004-08-01Not applicableUs
Xopenexsolution, concentrate1.25 mg/.5mLrespiratory (inhalation)Cardinal Health2004-08-01Not applicableUs
Xopenexsolution.31 mg/3mLrespiratory (inhalation)Akorn, Inc.2015-02-27Not applicableUs
Xopenexsolution, concentrate1.25 mg/.5mLrespiratory (inhalation)Akorn, Inc.2015-02-26Not applicableUs
Xopenexsolution1.25 mg/3mLrespiratory (inhalation)Sunovion Pharmaceuticals Inc.1999-04-01Not applicableUs
Xopenexsolution.63 mg/3mLrespiratory (inhalation)Sunovion Pharmaceuticals Inc.1999-04-01Not applicableUs
Xopenexsolution.31 mg/3mLrespiratory (inhalation)Sunovion Pharmaceuticals Inc.2002-03-01Not applicableUs
Xopenexsolution, concentrate1.25 mg/.5mLrespiratory (inhalation)Physicians Total Care, Inc.2009-04-21Not applicableUs
Xopenexsolution1.25 mg/3mLrespiratory (inhalation)Rebel Distributors Corp1999-04-01Not applicableUs
Xopenexsolution1.25 mg/3mLrespiratory (inhalation)Physicians Total Care, Inc.2005-10-20Not applicableUs
Xopenex HFAaerosol, metered45 ug/1oralSunovion Pharmaceuticals Inc.2005-12-01Not applicableUs
Xopenex HFAaerosol, metered45 ug/1oralPhysicians Total Care, Inc.2007-10-01Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Albuteroltablet4 mg/1oralMylan Pharmaceuticals Inc.1991-01-17Not applicableUs
Albuteroltablet2 mg/1oralMylan Pharmaceuticals Inc.1991-01-17Not applicableUs
Albuteroltablet4 mg/1oralMylan Institutional Inc.1997-04-29Not applicableUs
Albuteroltablet2 mg/1oralMylan Institutional Inc.1997-04-29Not applicableUs
Albuteroltablet4 mg/1oralPd Rx Pharmaceuticals, Inc.2011-05-04Not applicableUs
Albuterolaerosol, metered90 ug/1oralRebel Distributors Corp1996-08-14Not applicableUs
Albuterol Sulfatesolution2.5 mg/.5mLrespiratory (inhalation)Nephron Pharmaceuticals Corporation2001-06-26Not applicableUs
Albuterol Sulfatetablet, film coated, extended release8 mg/1oralMylan Pharmaceuticals Inc.2007-01-30Not applicableUs
Albuterol Sulfatesyrup2 mg/5mLoralTeva Pharmaceuticals USA Inc1992-05-01Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Ritedose Pharmaceuticals, LLC2011-12-05Not applicableUs
Albuterol Sulfatesolution1.5 mg/3mLrespiratory (inhalation)Physicians Total Care, Inc.2007-04-26Not applicableUs
Albuterol Sulfatesyrup2 mg/5mLoralActavis Pharma, Inc.2016-02-192016-04-21Us
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)REMEDYREPACK INC.2013-06-10Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Proficient Rx LP1997-09-17Not applicableUs
Albuterol Sulfatesolution2.5 mg/.5mLrespiratory (inhalation)Cardinal Health2001-06-26Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Sandoz Inc.2011-08-17Not applicableUs
Albuterol Sulfatesolution1.5 mg/3mLrespiratory (inhalation)Nephron Pharmaceuticals Corporation2004-06-28Not applicableUs
Albuterol Sulfatesolution2 mg/5mLoralPreferred Pharmaceuticals, Inc.2012-01-10Not applicableUs
Albuterol Sulfatesolution5 mg/mLrespiratory (inhalation)Physicians Total Care, Inc.1994-10-19Not applicableUs
Albuterol Sulfatetablet2 mg/1oralREMEDYREPACK INC.2013-05-07Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLintrabronchialREMEDYREPACK INC.2015-05-18Not applicableUs
Albuterol Sulfatesolution2 mg/5mLoralQualitest Pharmaceuticals2006-12-27Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Nephron Pharmaceuticals Corporation1997-09-17Not applicableUs
Albuterol Sulfatetablet, film coated, extended release4 mg/1oralMylan Pharmaceuticals Inc.2007-01-30Not applicableUs
Albuterol Sulfatesyrup2 mg/5mLoralPhysicians Total Care, Inc.1994-10-13Not applicableUs
Albuterol Sulfatetablet2 mg/1oralREMEDYREPACK INC.2013-03-06Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Aidarex Pharmaceuticals LLC2011-12-05Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLintrabronchialActavis Pharma, Inc.2010-11-04Not applicableUs
Albuterol Sulfatesolution.75 mg/3mLrespiratory (inhalation)Nephron Pharmaceuticals Corporation2010-03-31Not applicableUs
Albuterol Sulfatesolution5 mg/mLrespiratory (inhalation)Preferred Pharmaceuticals, Inc.2012-07-27Not applicableUs
Albuterol Sulfatesyrup2 mg/5mLocclusive dressing techniqueDispensing Solutions, Inc.1998-01-30Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Clinical Solutions Wholesale1997-09-17Not applicableUs
Albuterol Sulfatesolution5 mg/mLrespiratory (inhalation)Bausch & Lomb Incorporated1998-06-18Not applicableUs
Albuterol Sulfatesolution1.25 mg/3mLintrabronchialWatson Laboratories, Inc.2007-09-25Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLintrabronchialPreferred Pharmaceuticals, Inc.2015-04-21Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Physicians Total Care, Inc.2003-10-21Not applicableUs
Albuterol Sulfatesyrup2 mg/5mLoralRebel Distributors Corp1998-01-30Not applicableUs
Albuterol Sulfatesolution.63 mg/3mLintrabronchialWatson Laboratories, Inc.2007-09-25Not applicableUs
Albuterol Sulfatesyrup2 mg/5mLoralPreferred Pharmaceuticals, Inc2011-06-03Not applicableUs
Albuterol Sulfatetablet2.4 mg/1oralPhysicians Total Care, Inc.1993-08-13Not applicableUs
Albuterol Sulfatetablet4 mg/1oralAmerican Health Packaging2015-09-01Not applicableUs
Albuterol Sulfatetablet2 mg/1oralPreferred Pharmaceuticals, Inc.1989-12-05Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLintrabronchialA S Medication Solutions Llc2010-11-04Not applicableUs
Albuterol Sulfatesolution5 mg/mLrespiratory (inhalation)Hi Tech Pharmacal Co., Inc.1998-01-15Not applicableUs
Albuterol Sulfatetablet2 mg/1oralAmerican Health Packaging2015-09-01Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Rebel Distributors Corp.1997-09-17Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Mylan Pharmaceuticals, Inc.2012-10-15Not applicableUs
Albuterol Sulfatetablet4 mg/1oralPreferred Pharmaceuticals, Inc.1989-12-05Not applicableUs
Albuterol Sulfatetablet4 mg/1oralMutual Pharmaceutical Company, Inc.1989-12-05Not applicableUs
Albuterol Sulfatesyrup2 mg/5mLoralHi Tech Pharmacal Co., Inc.1998-01-30Not applicableUs
Albuterol Sulfatetablet4 mg/1oralbryant ranch prepack1989-12-05Not applicableUs
Albuterol Sulfatesolution1.5 mg/3mLrespiratory (inhalation)Cardinal Health2004-06-28Not applicableUs
Albuterol Sulfatesolution5 mg/mLrespiratory (inhalation)Rebel Distributors Corp.1998-01-15Not applicableUs
Albuterol Sulfatesolution.83 mg/mLrespiratory (inhalation)Preferred Pharmaceuticals, Inc1997-09-17Not applicableUs
Albuterol Sulfatetablet2 mg/1oralMutual Pharmaceutical Company, Inc.1989-12-05Not applicableUs
Albuterol Sulfatesyrup2 mg/5mLoralLake Erie Medical DBA Quality Care Products LLC2011-02-21Not applicableUs
Albuterol Sulfatetablet2 mg/1oralbryant ranch prepack1989-12-05Not applicableUs
Albuterol Sulfatesolution2.5 mg/3mLrespiratory (inhalation)Cardinal Health1997-09-17Not applicableUs
Albuterol Sulfate ERtablet, extended release8 mg/1oralDAVA Pharmaceuticals, Inc.2002-09-30Not applicableUs
Albuterol Sulfate ERtablet, extended release4 mg/1oralDAVA Pharmaceuticals, Inc.2002-09-30Not applicableUs
Apo-salvent 5mg/mlsolution5 mginhalation; oralApotex Inc1994-12-31Not applicableCanada
Apo-salvent Aem 100mcgmetered-dose aerosol100 mcginhalationApotex Inc1989-12-31Not applicableCanada
Apo-salvent Cfc Freemetered-dose aerosol100 mcginhalationApotex Inc2002-08-22Not applicableCanada
Apo-salvent Sterulessolution0.5 mginhalationApotex Inc2001-08-28Not applicableCanada
Apo-salvent Sterulessolution2 mginhalationApotex Inc1998-02-10Not applicableCanada
Apo-salvent Sterulessolution1 mginhalationApotex Inc1997-06-25Not applicableCanada
Apo-salvent Tablets - 2mgtablet2 mgoralApotex Inc1995-12-31Not applicableCanada
Apo-salvent Tablets - 4mgtablet4 mgoralApotex Inc1995-12-31Not applicableCanada
Levalbuterolsolution1.25 mg/3mLrespiratory (inhalation)Mylan Pharmaceuticals Inc.2013-03-15Not applicableUs
Levalbuterolsolution.63 mg/3mLrespiratory (inhalation)Mylan Pharmaceuticals Inc.2013-03-15Not applicableUs
Levalbuterolsolution1.25 mg/3mLrespiratory (inhalation)Teva Pharmaceuticals USA Inc2013-04-29Not applicableUs
Levalbuterolsolution.31 mg/3mLrespiratory (inhalation)Mylan Pharmaceuticals Inc.2013-03-15Not applicableUs
Levalbuterolsolution, concentrate1.25 mg/.5mLrespiratory (inhalation)Teva Pharmaceuticals USA Inc2014-12-16Not applicableUs
Levalbuterolsolution1.25 mg/3mLrespiratory (inhalation)Ritedose Pharmaceuticals, LLC2016-03-14Not applicableUs
Levalbuterolsolution.63 mg/3mLrespiratory (inhalation)Teva Pharmaceuticals USA Inc2013-04-29Not applicableUs
Levalbuterolsolution.63 mg/3mLrespiratory (inhalation)Ritedose Pharmaceuticals, LLC2016-03-14Not applicableUs
Levalbuterolsolution.31 mg/3mLrespiratory (inhalation)Teva Pharmaceuticals USA Inc2013-04-29Not applicableUs
Levalbuterolsolution.31 mg/3mLrespiratory (inhalation)Ritedose Pharmaceuticals, LLC2016-03-14Not applicableUs
Levalbuterol Hydrochloridesolution1.25 mg/.5mLrespiratory (inhalation)Cardinal Health2009-08-28Not applicableUs
Levalbuterol Hydrochloridesolution1.25 mg/3mLrespiratory (inhalation)Actavis Pharma, Inc.2014-06-10Not applicableUs
Levalbuterol Hydrochloridesolution.63 mg/3mLrespiratory (inhalation)Actavis Pharma, Inc.2014-06-10Not applicableUs
Levalbuterol Hydrochloridesolution1.25 mg/.5mLrespiratory (inhalation)Mylan Pharmaceuticals Inc.2009-08-28Not applicableUs
Levalbuterol Hydrochloridesolution.31 mg/3mLrespiratory (inhalation)Actavis Pharma, Inc.2014-06-10Not applicableUs
Levalbuterol Inhalationsolution.31 mg/3mLrespiratory (inhalation)Dr. Reddy?S Laboratories, Inc.2014-09-16Not applicableUs
Levalbuterol Inhalationsolution.63 mg/3mLrespiratory (inhalation)Dr. Reddy?S Laboratories, Inc.2014-09-16Not applicableUs
Levalbuterol Inhalationsolution1.25 mg/3mLrespiratory (inhalation)Dr. Reddy?S Laboratories, Inc.2014-09-16Not applicableUs
Levalbuterol Inhalationsolution1.25 mg/3mLrespiratory (inhalation)REMEDYREPACK INC.2015-05-26Not applicableUs
Vospire ERtablet, extended release8 mg/1oralDAVA Pharmaceuticals, Inc.2002-09-30Not applicableUs
Vospire ERtablet, extended release4 mg/1oralDAVA Pharmaceuticals, Inc.2002-09-30Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AccuNebNot Available
AerolinNot Available
AsmolNot Available
AsthalinNot Available
AsthaventNot Available
ProAirTeva
PROAIRHFANot Available
ProventilNot Available
SalamolNot Available
VentilanGlaxoSmithKline
VentolinGlaxoSmithKline
VentolineGlaxoSmithKline
VENTOLINHFANot Available
VentorlinGlaxoSmithKline
VoSpireNot Available
Brand mixtures
NameLabellerIngredients
Apo-salvent-ipravent SterulesApotex Inc
Combivent Inhalation AerosolBoehringer Ingelheim (Canada) Ltd Ltee
Combivent RespimatBoehringer Ingelheim Pharmaceuticals Inc.
Combivent UdvBoehringer Ingelheim (Canada) Ltd Ltee
DuonebMylan Specialty
IpramolIvax Pharmaceuticals Incorporated
Ipratropium Bromide and Albuterol SulfateTeva Pharmaceuticals USA Inc
Ratio-ipra Sal UdvTeva Canada Limited
Teva-combo SterinebsTeva Canada Limited
Salts
Name/CASStructureProperties
Levalbuterol hydrochloride
ThumbNot applicableDBSALT001453
Salbutamol sulfate
Thumb
  • InChI Key: BNPSSFBOAGDEEL-UHFFFAOYNA-N
  • Monoisotopic Mass: 576.271666328
  • Average Mass: 576.7
DBSALT000257
Salbutamol tartrate
ThumbNot applicableDBSALT001385
Categories
UNIIQF8SVZ843E
CAS number18559-94-9
WeightAverage: 239.3107
Monoisotopic: 239.152143543
Chemical FormulaC13H21NO3
InChI KeyInChIKey=NDAUXUAQIAJITI-UHFFFAOYSA-N
InChI
InChI=1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
IUPAC Name
4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
SMILES
CC(C)(C)NCC(O)C1=CC(CO)=C(O)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzyl alcohols. These are organic compounds containing the phenylmethanol substructure.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzyl alcohols
Direct ParentBenzyl alcohols
Alternative Parents
Substituents
  • Benzyl alcohol
  • Aralkylamine
  • Phenol
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Secondary amine
  • Secondary aliphatic amine
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, and other chronic bronchopulmonary disorders such as COPD.
PharmacodynamicsSalbutamol (INN) or albuterol (USAN), a moderately selective beta(2)-receptor agonist similar in structure to terbutaline, is widely used as a bronchodilator to manage asthma and other chronic obstructive airway diseases. The R-isomer, levalbuterol, is responsible for bronchodilation while the S-isomer increases bronchial reactivity. The R-enantiomer is sold in its pure form as Levalbuterol. The manufacturer of levalbuterol, Sepracor, has implied (although not directly claimed) that the presence of only the R-enantiomer produces fewer side-effects.
Mechanism of actionSalbutamol is a beta(2)-adrenergic agonist and thus it stimulates beta(2)-adrenergic receptors. Binding of albuterol to beta(2)-receptors in the lungs results in relaxation of bronchial smooth muscles. It is believed that salbutamol increases cAMP production by activating adenylate cyclase, and the actions of salbutamol are mediated by cAMP. Increased intracellular cyclic AMP increases the activity of cAMP-dependent protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular calcium concentrations. A lowered intracellular calcium concentration leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, salbutamol inhibits the release of bronchoconstricting agents from mast cells, inhibits microvascular leakage, and enhances mucociliary clearance.
Related Articles
AbsorptionSystemic absorption is rapid following aerosol administration.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hydrolyzed by esterases in tissue and blood to the active compound colterol. The drug is also conjugatively metabolized to salbutamol 4'-O-sulfate.

SubstrateEnzymesProduct
Salbutamol
Not Available
Salbutamol 4-O-sulfateDetails
Route of eliminationApproximately 72% of the inhaled dose is excreted in the urine within 24 hours, 28% as unchanged drug and 44% as metabolite.
Half life1.6 hours
ClearanceNot Available
ToxicityLD50=1100 mg/kg (orally in mice)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9812
Blood Brain Barrier-0.9659
Caco-2 permeable-0.7112
P-glycoprotein substrateSubstrate0.684
P-glycoprotein inhibitor INon-inhibitor0.8781
P-glycoprotein inhibitor IINon-inhibitor0.9673
Renal organic cation transporterNon-inhibitor0.8974
CYP450 2C9 substrateNon-substrate0.7897
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7074
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.9197
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9287
CYP450 3A4 inhibitorNon-inhibitor0.9343
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8834
Ames testNon AMES toxic0.8409
CarcinogenicityNon-carcinogens0.8863
BiodegradationNot ready biodegradable0.9734
Rat acute toxicity2.5275 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9564
hERG inhibition (predictor II)Non-inhibitor0.9288
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Armstrong pharmaceuticals inc
  • Genpharm inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Pliva inc
  • Schering corp sub schering plough corp
  • Glaxosmithkline
  • Teva global respiratory research llc
  • 3m pharmaceuticals inc
  • Dey lp
  • Actavis mid atlantic llc
  • Apotex inc richmond hill
  • Apotex inc
  • Bausch and lomb inc
  • Cobalt laboratories inc
  • Copley pharmaceutical inc
  • Hi tech pharmacal co inc
  • Holopack international
  • Landela pharmaceutical
  • Nephron pharmaceuticals corp
  • Nephron corp
  • Novex pharma
  • Roxane laboratories inc
  • Teva parenteral medicines inc
  • Watson laboratories inc
  • Wockhardt eu operations (swiss) ag
  • Amneal pharmaceuticals
  • Mova pharmaceuticals corp
  • Teva pharmaceuticals usa inc
  • Vintage pharmaceuticals llc
  • Vistapharm inc
  • Mylan pharmaceuticals inc
  • Muro pharmaceutical inc
  • Dava pharmaceuticals inc
  • American therapeutics inc
  • Mutual pharmaceutical co inc
  • Sandoz inc
  • Ucb inc
  • Warner chilcott div warner lambert co
  • Breath ltd
  • Sepracor inc
  • Teva Pharmaceuticals
Packagers
Dosage forms
FormRouteStrength
Metered-dose aerosolinhalation100 mcg
Aerosol, meteredoral90 ug/1
Tabletoral2 mg/1
Tabletoral4 mg/1
Solutionintrabronchial.63 mg/3mL
Solutionintrabronchial1.25 mg/3mL
Solutionintrabronchial2.5 mg/3mL
Solutionoral2 mg/5mL
Solutionrespiratory (inhalation).75 mg/3mL
Solutionrespiratory (inhalation).83 mg/mL
Solutionrespiratory (inhalation)1.5 mg/3mL
Solutionrespiratory (inhalation)2.5 mg/.5mL
Solutionrespiratory (inhalation)2.5 mg/3mL
Solutionrespiratory (inhalation)5 mg/mL
Syrupocclusive dressing technique2 mg/5mL
Syruporal2 mg/5mL
Tabletoral2.4 mg/1
Tablet, film coated, extended releaseoral4 mg/1
Tablet, film coated, extended releaseoral8 mg/1
Tablet, extended releaseoral4 mg/1
Tablet, extended releaseoral8 mg/1
Tabletoral2 mg
Tabletoral4 mg
Metered-dose aerosolinhalation; oral
Spray, meteredrespiratory (inhalation)
Solutioninhalation
Solutionrespiratory (inhalation)
Solutionrespiratory (inhalation).31 mg/3mL
Solutionrespiratory (inhalation).63 mg/3mL
Solutionrespiratory (inhalation)1.25 mg/3mL
Solution, concentraterespiratory (inhalation)1.25 mg/.5mL
Solutionrespiratory (inhalation)1.25 mg/.5mL
Metered-dose aerosoloral100 mcg
Solutioninhalation0.5 mg
Solutioninhalation; oral5 mg
Solutionoral0.4 mg
Powder, meteredrespiratory (inhalation)90 ug/1
Aerosol, meteredrespiratory (inhalation)108 ug/1
Solutioninhalation5 mg
Liquidinhalation1 mg
Liquidinhalation0.05 %
Liquidinhalation0.1 %
Liquidinhalation0.2 %
Solutioninhalation1 mg
Solutioninhalation2 mg
Powderinhalation400 mcg
Powderinhalation200 mcg
Aerosol, meteredrespiratory (inhalation)90 ug/1
Solutionintramuscular0.5 mg
Solutionintravenous0.25 mg
Solutionintravenous1 mg
Liquidintramuscular.5 mg
Liquidintravenous1 mg
Liquidintravenous.25 mg
Solutioninhalation2.5 mg
Liquidinhalation1.25 mg
Liquidinhalation2.5 mg
Solutioninhalation1.25 mg
Liquidinhalation5 mg
Liquidoral0.4 mg
Liquidoral.4 mg
Capsuleinhalation200 mcg
Capsuleinhalation400 mcg
Aerosol, meteredoral45 ug/1
Prices
Unit descriptionCostUnit
Xopenex 0.63 mg/3 ml solution64.2USD ml
Proventil HFA 108 (90 Base)mcg/act Aerosol 6.7 gm Inhaler55.09USD inhaler
Xopenex HFA 45 mcg/act Aerosol 15 gm Inhaler53.84USD inhaler
AccuNeb 0.63 mg/3ml Neb. Solution 1 Box= 25 Vials53.14USD plastic
AccuNeb 1.25 mg/3ml Neb. Solution 1 Box= 25 Vials53.14USD plastic
ProAir HFA 108 (90 Base)mcg/act Aerosol 8.5 gm Inhaler45.99USD inhaler
Ventolin HFA 108 (90 Base)mcg/act Aerosol 18 gm Inhaler39.99USD inhaler
Proair hfa 90 mcg inhaler12.62USD g
Proventil hfa 90 mcg inhaler8.07USD g
Xopenex hfa 45 mcg inhaler6.12USD g
Xopenex 0.31 mg/3ml (1 Box = 24, 3ml Vials)4.87USD plastic
Xopenex 1.25 mg/3ml (1 Box = 24, 3ml Vials)4.87USD plastic
Xopenex 0.63 mg/3ml (1 Box = 24, 3ml Vials)4.71USD plastic
Xopenex 1.25 mg/3 ml solution2.96USD ml
Ventolin hfa 90 mcg inhaler2.01USD g
Xopenex 0.31 mg/3 ml solution1.56USD ml
Ventolin 5 mg/ml Solution1.13USD ml
Ventolin Nebules P.F. 2 mg/ml Unit Dose Solution0.88USD ml
Accuneb 0.63 mg/3 ml inh solution0.68USD ml
Accuneb 1.25 mg/3 ml inh solution0.68USD ml
Mylan-Salbutamol 5 mg/ml Solution0.62USD ml
Pms-Salbutamol 5 mg/ml Solution0.62USD ml
Ratio-Salbutamol 5 mg/ml Solution0.62USD ml
Sandoz Salbutamol 5 mg/ml Solution0.62USD ml
Mylan-Salbutamol Sterinebs P.F. 2 mg/ml Unit Dose Solution0.48USD ml
Pms-Salbutamol Polyneb 2 mg/ml Unit Dose Solution0.48USD ml
Ratio-Salbutamol Uni Dose P.F. 2 mg/ml Unit Dose Solution0.48USD ml
Ventolin Nebules P.F. 1 mg/ml Solution0.47USD ml
Mylan-Salbutamol Sterinebs P.F. 1 mg/ml Solution0.25USD ml
Pms-Salbutamol 1 mg/ml Solution0.25USD ml
Ratio-Salbutamol Sulf U.D.P.F. 1 mg/ml Solution0.25USD ml
Apo-Salvent 4 mg Tablet0.22USD tablet
Pms-Salbutamol 0.5 mg/ml Solution0.16USD ml
Ratio-Salbutamol Unit Dose P.F 0.5 mg/ml Solution0.16USD ml
Apo-Salvent 2 mg Tablet0.13USD tablet
Pms-Salbutamol 400 mcg/ml Liquid0.05USD ml
Ratio-Salbutamol Hfa 100 mcg/dose Metered Dose Aerosol0.04USD dose
Airomir Cfc-Free 100 mcg/dose Metered Dose Aerosol0.03USD dose
Apo-Salvent Cfc Free 100 mcg/dose Metered Dose Aerosol0.03USD dose
Ventolin Hfa 100 mcg/dose Metered Dose Aerosol0.03USD dose
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2125665 No2001-06-122012-12-04Canada
CA2125667 No2000-06-132012-12-04Canada
US5775321 No1995-07-072015-07-07Us
US5836299 No1995-11-172015-11-17Us
US5964416 No1996-10-042016-10-04Us
US6006745 No1996-12-282016-12-28Us
US6149054 No1996-12-192016-12-19Us
US6161724 Yes1998-07-162018-07-16Us
US6170717 Yes1998-06-232018-06-23Us
US6176442 No1996-10-042016-10-04Us
US6315173 Yes1998-06-232018-06-23Us
US6352684 No1992-11-282009-11-28Us
US6431168 Yes1998-12-082018-12-08Us
US6435372 Yes1998-07-162018-07-16Us
US6446627 No1997-12-182017-12-18Us
US6451289 No2001-03-212021-03-21Us
US6453795 No1996-12-052016-12-05Us
US6510969 Yes1998-06-232018-06-23Us
US6558651 Yes1997-06-192017-06-19Us
US6632842 No2001-12-282021-12-28Us
US6701917 No2001-06-232021-06-23Us
US6702997 No2001-12-282021-12-28Us
US6718972 No2001-06-232021-06-23Us
US6726124 No1996-10-042016-10-04Us
US6743413 Yes2001-12-012021-12-01Us
US6748947 No2001-06-232021-06-23Us
US6846413 No1998-08-282018-08-28Us
US6871646 No2001-06-232021-06-23Us
US6938796 Yes1998-07-162018-07-16Us
US6966467 Yes1998-06-232018-06-23Us
US6977042 No1998-08-282018-08-28Us
US6988496 No2000-02-232020-02-23Us
US6997349 Yes1998-07-162018-07-16Us
US7104470 No1996-10-042016-10-04Us
US7105152 No2003-09-122023-09-12Us
US7107986 Yes1998-12-062018-12-06Us
US7143908 Yes1998-07-162018-07-16Us
US7246615 No1996-05-312016-05-31Us
US7256310 No2004-10-082024-10-08Us
US7284474 No2004-08-262024-08-26Us
US7350676 Yes1999-02-242019-02-24Us
US7396341 No2006-10-102026-10-10Us
US7500444 Yes2006-08-262026-08-26Us
US7540282 No2003-05-062023-05-06Us
US7566445 No1997-06-042017-06-04Us
US7802568 No1999-02-262019-02-26Us
US7832351 Yes2003-12-192023-12-19Us
US7837235 No2008-03-132028-03-13Us
US7896264 No2005-05-262025-05-26Us
US7988001 No2001-08-042021-08-04Us
US8006690 No2001-06-232021-06-23Us
US8132712 No2008-09-072028-09-07Us
US8651103 No2008-03-262028-03-26Us
US8733341 No2009-12-162029-12-16Us
US8765153 No2003-12-082023-12-08Us
US8834849 No1997-06-042017-06-04Us
US8978966 No2012-01-132032-01-13Us
US9027967 No2007-03-312027-03-31Us
US9216260 No2011-06-282031-06-28Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point147-149Lunts, L.H.C. and Toon, P.; U.S. Patent 3,644,353; February 22,1972; assigned to Allen & Hanburys Ltd.
water solubility1.41E+004 mg/LYALKOWSKY,SH & HE,Y (2003)
logP1.4Not Available
logS-1.22ADME Research, USCD
pKa10.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.15 mg/mLALOGPS
logP0.44ALOGPS
logP0.34ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)10.12ChemAxon
pKa (Strongest Basic)9.4ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area72.72 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity67.87 m3·mol-1ChemAxon
Polarizability26.86 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Toshikuni Kawazi, Masahiro Ono, Nobuko Inoue, “Salbutamol-containing plaster and method of producing same.” U.S. Patent US5068103, issued February, 1984.

US5068103
General ReferencesNot Available
External Links
ATC CodesR03AC02R03AK04R03AL02R03CC02
AHFS Codes
  • 12:12.08.12
  • 48:12.04.12
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (52.5 KB)
Interactions
Drug Interactions
Drug
AcebutololThe risk or severity of adverse effects can be increased when Acebutolol is combined with Salbutamol.
AmitriptylineThe risk or severity of adverse effects can be increased when Amitriptyline is combined with Salbutamol.
AmphetamineThe risk or severity of adverse effects can be increased when Amphetamine is combined with Salbutamol.
AtomoxetineAtomoxetine may increase the tachycardic activities of Salbutamol.
AtosibanThe risk or severity of adverse effects can be increased when Salbutamol is combined with Atosiban.
BenzphetamineThe risk or severity of adverse effects can be increased when Benzphetamine is combined with Salbutamol.
BetahistineThe therapeutic efficacy of Salbutamol can be decreased when used in combination with Betahistine.
ChlorphentermineThe risk or severity of adverse effects can be increased when Chlorphentermine is combined with Salbutamol.
CitalopramSalbutamol may increase the QTc-prolonging activities of Citalopram.
ClenbuterolThe risk or severity of adverse effects can be increased when Clenbuterol is combined with Salbutamol.
DobutamineThe risk or severity of adverse effects can be increased when Dobutamine is combined with Salbutamol.
DofetilideSalbutamol may increase the QTc-prolonging activities of Dofetilide.
DopamineThe risk or severity of adverse effects can be increased when Dopamine is combined with Salbutamol.
DoxofyllineThe risk or severity of adverse effects can be increased when Salbutamol is combined with Doxofylline.
DronabinolDronabinol may increase the tachycardic activities of Salbutamol.
EpinephrineThe risk or severity of adverse effects can be increased when Epinephrine is combined with Salbutamol.
EsmololEsmolol may decrease the activities of Salbutamol.
FenoterolThe risk or severity of adverse effects can be increased when Fenoterol is combined with Salbutamol.
FormoterolThe risk or severity of adverse effects can be increased when Formoterol is combined with Salbutamol.
GoserelinSalbutamol may increase the QTc-prolonging activities of Goserelin.
IobenguaneThe therapeutic efficacy of Iobenguane can be decreased when used in combination with Salbutamol.
IsoprenalineThe risk or severity of adverse effects can be increased when Isoprenaline is combined with Salbutamol.
LabetalolThe risk or severity of adverse effects can be increased when Labetalol is combined with Salbutamol.
LeuprolideSalbutamol may increase the QTc-prolonging activities of Leuprolide.
LinezolidLinezolid may increase the hypertensive activities of Salbutamol.
LoxapineThe risk or severity of adverse effects can be increased when Salbutamol is combined with Loxapine.
MephentermineThe risk or severity of adverse effects can be increased when Mephentermine is combined with Salbutamol.
MetaraminolThe risk or severity of adverse effects can be increased when Metaraminol is combined with Salbutamol.
MethamphetamineThe risk or severity of adverse effects can be increased when Methamphetamine is combined with Salbutamol.
MethoxamineThe risk or severity of adverse effects can be increased when Methoxamine is combined with Salbutamol.
MidodrineThe risk or severity of adverse effects can be increased when Midodrine is combined with Salbutamol.
MifepristoneMifepristone may increase the QTc-prolonging activities of Salbutamol.
NadololNadolol may decrease the activities of Salbutamol.
NaphazolineThe risk or severity of adverse effects can be increased when Naphazoline is combined with Salbutamol.
NorepinephrineThe risk or severity of adverse effects can be increased when Norepinephrine is combined with Salbutamol.
OrciprenalineThe risk or severity of adverse effects can be increased when Orciprenaline is combined with Salbutamol.
OxymetazolineThe risk or severity of adverse effects can be increased when Oxymetazoline is combined with Salbutamol.
PhenelzineThe risk or severity of adverse effects can be increased when Phenelzine is combined with Salbutamol.
PhenmetrazineThe risk or severity of adverse effects can be increased when Phenmetrazine is combined with Salbutamol.
PhentermineThe risk or severity of adverse effects can be increased when Phentermine is combined with Salbutamol.
PhenylephrineThe risk or severity of adverse effects can be increased when Phenylephrine is combined with Salbutamol.
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Phenylpropanolamine is combined with Salbutamol.
RitodrineThe risk or severity of adverse effects can be increased when Ritodrine is combined with Salbutamol.
SalmeterolThe risk or severity of adverse effects can be increased when Salmeterol is combined with Salbutamol.
Tedizolid PhosphateTedizolid Phosphate may increase the hypertensive activities of Salbutamol.
TerbutalineThe risk or severity of adverse effects can be increased when Terbutaline is combined with Salbutamol.
TorasemideSalbutamol may increase the hypokalemic activities of Torasemide.
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Salbutamol.
TrichlormethiazideSalbutamol may increase the hypokalemic activities of Trichlormethiazide.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Protein homodimerization activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Gene Name:
ADRB2
Uniprot ID:
P07550
Molecular Weight:
46458.32 Da
References
  1. Brichetto L, Milanese M, Song P, Patrone M, Crimi E, Rehder K, Brusasco V: Beclomethasone rapidly ablates allergen-induced beta 2-adrenoceptor pathway dysfunction in human isolated bronchi. Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L133-9. Epub 2002 Aug 16. [PubMed:12388338 ]
  2. Chong LK, Suvarna K, Chess-Williams R, Peachell PT: Desensitization of beta2-adrenoceptor-mediated responses by short-acting beta2-adrenoceptor agonists in human lung mast cells. Br J Pharmacol. 2003 Feb;138(3):512-20. [PubMed:12569076 ]
  3. Yamanishi T, Chapple CR, Yasuda K, Yoshida K, Chess-Williams R: Role of beta-adrenoceptor subtypes in mediating relaxation of the pig bladder trigonal muscle in vitro. Neurourol Urodyn. 2003;22(4):338-42. [PubMed:12808710 ]
  4. Brouri F, Hanoun N, Mediani O, Saurini F, Hamon M, Vanhoutte PM, Lechat P: Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis. Eur J Pharmacol. 2004 Feb 6;485(1-3):227-34. [PubMed:14757145 ]
  5. Choudhry S, Ung N, Avila PC, Ziv E, Nazario S, Casal J, Torres A, Gorman JD, Salari K, Rodriguez-Santana JR, Toscano M, Sylvia JS, Alioto M, Castro RA, Salazar M, Gomez I, Fagan JK, Salas J, Clark S, Lilly C, Matallana H, Selman M, Chapela R, Sheppard D, Weiss ST, Ford JG, Boushey HA, Drazen JM, Rodriguez-Cintron W, Silverman EK, Burchard EG: Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med. 2005 Mar 15;171(6):563-70. Epub 2004 Nov 19. [PubMed:15557128 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Receptor signaling protein activity
Specific Function:
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Gene Name:
ADRB1
Uniprot ID:
P08588
Molecular Weight:
51322.1 Da
References
  1. Baker JG: The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22. [PubMed:15655528 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on June 28, 2016 03:06