You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameGlipizide
Accession NumberDB01067  (APRD00436)
TypeSmall Molecule
GroupsApproved
Description

An oral hypoglycemic agent which is rapidly absorbed and completely metabolized. [PubChem]

Structure
Thumb
Synonyms
1-Cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea
Aldiab
CP 28,720
CP 28720
CP-28,720
Digrin
Dipazide
Glibenese
Glibetin
Glican
Glidiab
Glipid
Glipizida
Glipizidum
Gluco-rite
Glucolip
Glucotrol
Glucozide
Glupitel
Glupizide
Glyde
Glydiazinamide
K 4024
Melizide
Mindiab
Minidab
Minidiab
Minodiab
N-{4-[beta-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-n'-cyclohexylurea
Napizide
Ozidia
Sucrazide
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Glipizidetablet, extended release5 mg/1oralREMEDYREPACK INC.2011-12-08Not applicableUs
Glipizide ERtablet, extended release10 mg/1oralCardinal Health1994-04-26Not applicableUs
Glipizide XLtablet, extended release2.5 mg/1oralCardinal Health1994-04-26Not applicableUs
Glipizide XLtablet, extended release5 mg/1oralGreenstone LLC2004-06-11Not applicableUs
Glipizide XLtablet, extended release10 mg/1oralGreenstone LLC2013-05-29Not applicableUs
Glipizide XLtablet, extended release5 mg/1oralGreenstone LLC2013-05-29Not applicableUs
Glipizide XLtablet, extended release10 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Glipizide XLtablet, extended release2.5 mg/1oralGreenstone LLC2013-05-29Not applicableUs
Glipizide XLtablet, extended release5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizide XLtablet, extended release10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizide XLtablet, extended release5 mg/1oralSt Marys Medical Park Pharmacy2014-05-23Not applicableUs
Glipizide XLtablet, extended release2.5 mg/1oralCardinal Health1994-04-26Not applicableUs
Glipizide XLtablet, extended release10 mg/1oralGreenstone LLC2004-06-11Not applicableUs
Glucotroltablet10 mg/1oralRoerig1984-05-08Not applicableUs
Glucotroltablet5 mg/1oralRoerig1984-05-08Not applicableUs
Glucotroltablet10 mg/1oralPd Rx Pharmaceuticals, Inc.1984-05-08Not applicableUs
Glucotrol XLtablet, extended release2.5 mg/1oralPhysicians Total Care, Inc.2003-05-08Not applicableUs
Glucotrol XLtablet, extended release2.5 mg/1oralRoerig2013-07-15Not applicableUs
Glucotrol XLtablet, extended release5 mg/1oralPhysicians Total Care, Inc.1994-08-01Not applicableUs
Glucotrol XLtablet, extended release10 mg/1oralPhysicians Total Care, Inc.1994-09-30Not applicableUs
Glucotrol XLtablet, extended release10 mg/1oralRoerig1999-04-10Not applicableUs
Glucotrol XLtablet, extended release5 mg/1oralRoerig1994-04-26Not applicableUs
Glucotrol XLtablet, extended release10 mg/1oralRoerig2013-05-09Not applicableUs
Glucotrol XLtablet, extended release5 mg/1oralRoerig2013-10-01Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Glipizidetablet5 mg/1oralNorthwind Pharmaceuticals2014-12-29Not applicableUs
Glipizidetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2014-09-05Not applicableUs
Glipizidetablet5 mg/1oralContract Pharmacy Services Pa2010-04-05Not applicableUs
Glipizidetablet5 mg/1oralIVAX Pharmaceuticals Inc.1995-09-122015-10-31Us
Glipizidetablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1994-05-10Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2010-11-23Not applicableUs
Glipizidetablet5 mg/1oralSTAT Rx USA LLC1995-02-27Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2011-04-28Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2012-09-24Not applicableUs
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizidetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.1995-04-07Not applicableUs
Glipizidetablet5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Glipizidetablet5 mg/1oralAphena Pharma Solutions Tennessee, Llc1995-04-07Not applicableUs
Glipizidetablet5 mg/1oralAccord Healthcare Inc.2011-03-01Not applicableUs
Glipizidetablet, extended release10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-08Not applicableUs
Glipizidetablet, film coated, extended release10 mg/1oralPar Pharmaceutical, Inc.2013-09-23Not applicableUs
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2013-10-03Not applicableUs
Glipizidetablet10 mg/1oralPhysicians Total Care, Inc.1994-11-18Not applicableUs
Glipizidetablet5 mg/1oralClinical Solutions Wholesale1995-04-07Not applicableUs
Glipizidetablet5 mg/1oralbryant ranch prepack1995-02-27Not applicableUs
Glipizidetablet10 mg/1oralLegacy Pharmaceutical Packaging, Llc1995-04-07Not applicableUs
Glipizidetablet5 mg/1oralMylan Pharmaceuticals Inc.1994-05-10Not applicableUs
Glipizidetablet5 mg/1oralAidarex Pharmaceuticals LLC2002-09-25Not applicableUs
Glipizidetablet10 mg/1oralUpsher Smith Laboratories, Inc.2015-03-09Not applicableUs
Glipizidetablet10 mg/1oralBlenheim Pharmacal, Inc.2013-09-30Not applicableUs
Glipizidetablet10 mg/1oralMylan Institutional Inc.1994-07-12Not applicableUs
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizidetablet5 mg/1oralSt Marys Medical Park Pharmacy2013-05-09Not applicableUs
Glipizidetablet10 mg/1oralMc Kesson Contract Packaging2011-11-22Not applicableUs
Glipizidetablet, film coated, extended release5 mg/1oralPar Pharmaceutical, Inc.2013-09-23Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2013-03-01Not applicableUs
Glipizidetablet5 mg/1oralPhysicians Total Care, Inc.1994-07-26Not applicableUs
Glipizidetablet10 mg/1oralClinical Solutions Wholesale1995-02-27Not applicableUs
Glipizidetablet5 mg/1oralbryant ranch prepack1995-02-27Not applicableUs
Glipizidetablet5 mg/1oralLegacy Pharmaceutical Packaging, Llc1995-04-07Not applicableUs
Glipizidetablet, film coated, extended release10 mg/1oralMylan Pharmaceuticals Inc.2015-10-28Not applicableUs
Glipizidetablet5 mg/1oralUpsher Smith Laboratories, Inc.2015-03-09Not applicableUs
Glipizidetablet5 mg/1oralBlenheim Pharmacal, Inc.2013-09-30Not applicableUs
Glipizidetablet5 mg/1oralMylan Institutional Inc.1994-07-12Not applicableUs
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizidetablet10 mg/1oralCardinal Health2010-11-04Not applicableUs
Glipizidetablet10 mg/1oralSt Marys Medical Park Pharmacy2013-05-09Not applicableUs
Glipizidetablet10 mg/1oralMed Vantx, Inc.2012-03-18Not applicableUs
Glipizidetablet5 mg/1oralMc Kesson Contract Packaging2011-10-03Not applicableUs
Glipizidetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-04-07Not applicableUs
Glipizidetablet10 mg/1oralSandoz Inc1995-04-07Not applicableUs
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2011-05-11Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2013-05-30Not applicableUs
Glipizidetablet10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Glipizidetablet10 mg/1oralClinical Solutions Wholesale1995-04-07Not applicableUs
Glipizidetablet5 mg/1oralProficient Rx LP2011-03-01Not applicableUs
Glipizidetablet, film coated, extended release5 mg/1oralMylan Pharmaceuticals Inc.2015-10-28Not applicableUs
Glipizidetablet10 mg/1oralUnit Dose Services1995-02-27Not applicableUs
Glipizidetablet10 mg/1oralH.J. Harkins Company, Inc.1995-02-27Not applicableUs
Glipizidetablet5 mg/1oralCardinal Health2010-11-04Not applicableUs
Glipizidetablet10 mg/1oralApotex Corp.2002-09-25Not applicableUs
Glipizidetablet5 mg/1oralTYA Pharmaceuticals2011-03-01Not applicableUs
Glipizidetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs
Glipizidetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-03-01Not applicableUs
Glipizidetablet5 mg/1oralBlenheim Pharmacal, Inc.2012-01-18Not applicableUs
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2011-09-26Not applicableUs
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2013-05-22Not applicableUs
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Glipizidetablet10 mg/1oralSun Pharmaceutical Industries, Inc.2009-07-31Not applicableUs
Glipizidetablet10 mg/1oralProficient Rx LP2011-03-01Not applicableUs
Glipizidetablet5 mg/1oralUnit Dose Services1995-02-27Not applicableUs
Glipizidetablet, film coated, extended release2.5 mg/1oralMylan Pharmaceuticals Inc.2015-10-28Not applicableUs
Glipizidetablet10 mg/1oralRebel Distributors Corp1995-02-27Not applicableUs
Glipizidetablet5 mg/1oralSandoz Inc1995-04-07Not applicableUs
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2014-06-16Not applicableUs
Glipizidetablet, film coated, extended release2.5 mg/1oralPhysicians Total Care, Inc.2005-07-25Not applicableUs
Glipizidetablet5 mg/1oralApotex Corp.2002-09-25Not applicableUs
Glipizidetablet10 mg/1oralPreferred Pharmaceuticals,Inc.2011-04-25Not applicableUs
Glipizidetablet10 mg/1oralWatson Laboratories, Inc.1995-02-27Not applicableUs
Glipizidetablet10 mg/1oralBlenheim Pharmacal, Inc.2010-09-09Not applicableUs
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2011-06-27Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2013-01-02Not applicableUs
Glipizidetablet5 mg/1oralSun Pharmaceutical Industries, Inc.2009-07-31Not applicableUs
Glipizidetablet5 mg/1oralProficient Rx LP1995-04-07Not applicableUs
Glipizidetablet10 mg/1oralA S Medication Solutions2011-07-18Not applicableUs
Glipizidetablet5 mg/1oralRebel Distributors Corp1995-02-27Not applicableUs
Glipizidetablet, extended release2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-08Not applicableUs
Glipizidetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-04-07Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2014-06-16Not applicableUs
Glipizidetablet, film coated, extended release5 mg/1oralPhysicians Total Care, Inc.2005-01-18Not applicableUs
Glipizidetablet10 mg/1oralGolden State Medical Supply Inc.2012-09-20Not applicableUs
Glipizidetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2013-02-18Not applicableUs
Glipizidetablet5 mg/1oralWatson Laboratories, Inc.1995-02-27Not applicableUs
Glipizidetablet10 mg/1oralNorthwind Pharmaceuticals2014-12-30Not applicableUs
Glipizidetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizidetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.1995-02-27Not applicableUs
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2014-10-03Not applicableUs
Glipizidetablet10 mg/1oralAphena Pharma Solutions Tennessee, Llc1995-04-07Not applicableUs
Glipizidetablet10 mg/1oralIVAX Pharmaceuticals Inc.1995-08-312015-11-30Us
Glipizidetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1994-05-10Not applicableUs
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2011-04-18Not applicableUs
Glipizidetablet10 mg/1oralSTAT Rx USA LLC1995-02-27Not applicableUs
Glipizidetablet, film coated, extended release5 mg/1oralREMEDYREPACK INC.2011-06-01Not applicableUs
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2013-01-03Not applicableUs
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizidetablet5 mg/1oralA S Medication Solutions2011-07-18Not applicableUs
Glipizidetablet10 mg/1oralAccord Healthcare Inc.2011-03-01Not applicableUs
Glipizidetablet, extended release5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-08Not applicableUs
Glipizidetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-05-31Not applicableUs
Glipizidetablet, film coated, extended release10 mg/1oralPhysicians Total Care, Inc.2004-01-30Not applicableUs
Glipizidetablet5 mg/1oralGolden State Medical Supply Inc.2012-09-20Not applicableUs
Glipizidetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2013-02-18Not applicableUs
Glipizidetablet10 mg/1oralMylan Pharmaceuticals Inc.1994-05-10Not applicableUs
Glipizidetablet10 mg/1oralAidarex Pharmaceuticals LLC2002-09-25Not applicableUs
Glipizide ERtablet, film coated, extended release2.5 mg/1oralAvera Mc Kennan Hospital2015-11-02Not applicableUs
Glipizide ERtablet, extended release2.5 mg/1oralActavis Elizabeth LLC2003-09-08Not applicableUs
Glipizide ERtablet, film coated, extended release10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-11-07Not applicableUs
Glipizide ERtablet, film coated, extended release10 mg/1oralPd Rx Pharmaceuticals, Inc.2003-11-07Not applicableUs
Glipizide ERtablet, film coated, extended release5 mg/1oralDispensing Solutions, Inc.2003-11-01Not applicableUs
Glipizide ERtablet, film coated, extended release2.5 mg/1oralWatson Laboratories, Inc.2006-04-01Not applicableUs
Glipizide ERtablet, film coated, extended release10 mg/1oralWatson Laboratories, Inc.2003-11-07Not applicableUs
Glipizide ERtablet, film coated, extended release10 mg/1oralCarilion Materials Management2003-11-07Not applicableUs
Glipizide ERtablet, film coated, extended release2.5 mg/1oralRebel Distributors Corp2006-04-01Not applicableUs
Glipizide ERtablet, film coated, extended release5 mg/1oralWatson Laboratories, Inc.2003-11-01Not applicableUs
Glipizide ERtablet, film coated, extended release2.5 mg/1oralAmerican Health Packaging2008-10-30Not applicableUs
Glipizide ERtablet, film coated, extended release5 mg/1oralUnit Dose Services2003-11-01Not applicableUs
Glipizide ERtablet, film coated, extended release2.5 mg/1oralbryant ranch prepack2006-04-01Not applicableUs
Glipizide ERtablet, extended release10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Glipizide ERtablet, film coated, extended release10 mg/1oralAmerican Health Packaging2008-06-09Not applicableUs
Glipizide ERtablet, extended release10 mg/1oralActavis Elizabeth LLC2003-09-08Not applicableUs
Glipizide ERtablet, film coated, extended release5 mg/1oralbryant ranch prepack2003-11-01Not applicableUs
Glipizide ERtablet, film coated, extended release10 mg/1oralPar Pharmaceuticals, Inc.2015-07-02Not applicableUs
Glipizide ERtablet, film coated, extended release5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-11-01Not applicableUs
Glipizide ERtablet, film coated, extended release10 mg/1oralDIRECT RX2015-01-01Not applicableUs
Glipizide ERtablet, film coated, extended release5 mg/1oralAmerican Health Packaging2008-06-09Not applicableUs
Glipizide ERtablet, extended release5 mg/1oralActavis Elizabeth LLC2003-09-08Not applicableUs
Glipizide ERtablet, film coated, extended release5 mg/1oralPar Pharmaceuticals, Inc.2015-07-02Not applicableUs
Glipizideertablet, film coated, extended release10 mg/1oralbryant ranch prepack2003-11-07Not applicableUs
Glipizideer ERtablet, film coated, extended release5 mg/1oralPd Rx Pharmaceuticals, Inc.2003-11-01Not applicableUs
Glipizideer ERtablet, film coated, extended release10 mg/1oralREMEDYREPACK INC.2013-11-12Not applicableUs
Glipizideer ERtablet, film coated, extended release10 mg/1oralAidarex Pharmaceuticals LLC2003-11-07Not applicableUs
Glipizideer ERtablet, film coated, extended release5 mg/1oralAidarex Pharmaceuticals LLC2003-11-01Not applicableUs
Glipizideer ERtablet, film coated, extended release2.5 mg/1oralREMEDYREPACK INC.2013-11-12Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
GlibenesePfizer
GlibénèseDexo
GlibetinJohnson
GlipinSwiss Pharm
GlixYSP
MindiabPfizer
MinidiabPfizer
Zitrol XRSquare
Brand mixtures
NameLabellerIngredients
Glipizide and Metformin HClHeritage Pharmaceuticals Inc.
Glipizide and Metformin HydrochlorideTeva Pharmaceuticals USA Inc
SaltsNot Available
Categories
UNIIX7WDT95N5C
CAS number29094-61-9
WeightAverage: 445.535
Monoisotopic: 445.178375067
Chemical FormulaC21H27N5O4S
InChI KeyInChIKey=ZJJXGWJIGJFDTL-UHFFFAOYSA-N
InChI
InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
IUPAC Name
N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-5-methylpyrazine-2-carboxamide
SMILES
CC1=CN=C(C=N1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentBenzenesulfonamides
Alternative Parents
Substituents
  • Benzenesulfonamide
  • Pyrazinecarboxamide
  • Pyrazine carboxylic acid or derivatives
  • Phenethylamine
  • Sulfonylurea
  • Cyclohexylamine
  • Pyrazine
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor use as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM; type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory.
PharmacodynamicsGlipizide, a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II. The primary mode of action of glipizide in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet tissue and is thus dependent on functioning beta cells in the pancreatic islets. In humans glipizide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. In man, stimulation of insulin secretion by glipizide in response to a meal is undoubtedly of major importance. Fasting insulin levels are not elevated even on long-term glipizide administration, but the postprandial insulin response continues to be enhanced after at least 6 months of treatment. Some patients fail to respond initially, or gradually lose their responsiveness to sulfonylurea drugs, including glipizide.
Mechanism of actionSulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
Related Articles
AbsorptionGastrointestinal absorption is uniform, rapid, and essentially complete.
Volume of distribution
  • 11 L
Protein binding98-99%, primarily to albumin.
Metabolism

Hepatic. The major metabolites of glipizide are products of aromatic hydroxylation and have no hypoglycemic activity. A minor metabolite which accounts for less than 2% of a dose, an acetylaminoethyl benzine derivatives, is reported to have 1/10 to 1/3 as much hypoglycemic activity as the parent compound.

SubstrateEnzymesProduct
Glipizide
Not Available
3-cis-HydroxyglipizideDetails
Glipizide
4-trans-HydroxyglipizideDetails
Route of eliminationThe primary metabolites are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine.
Half life2-5 hours
ClearanceNot Available
ToxicityThe acute oral toxicity was extremely low in all species tested (LD50 greater than 4 g/kg). Overdosage of sulfonylureas including glipizide can produce hypoglycemia.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
rs1057910 CYP2C9*1C AllelePoor drug metabolizer, lower dose requirements10208645
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9262
Blood Brain Barrier+0.5599
Caco-2 permeable-0.7025
P-glycoprotein substrateSubstrate0.5326
P-glycoprotein inhibitor INon-inhibitor0.7469
P-glycoprotein inhibitor IINon-inhibitor0.9302
Renal organic cation transporterNon-inhibitor0.8322
CYP450 2C9 substrateSubstrate0.5731
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.719
CYP450 1A2 substrateNon-inhibitor0.9501
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.7745
CarcinogenicityNon-carcinogens0.826
BiodegradationNot ready biodegradable0.9703
Rat acute toxicity2.1662 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9118
hERG inhibition (predictor II)Non-inhibitor0.8539
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, film coated, extended releaseoral10 mg/1
Tablet, film coated, extended releaseoral2.5 mg/1
Tablet, film coated, extended releaseoral5 mg/1
Tablet, film coatedoral
Tabletoral10 mg/1
Tabletoral5 mg/1
Tablet, extended releaseoral10 mg/1
Tablet, extended releaseoral2.5 mg/1
Tablet, extended releaseoral5 mg/1
Prices
Unit descriptionCostUnit
Glipizide powder36.11USD g
Glucotrol XL 10 mg 24 Hour tablet1.53USD tablet
Glucotrol xl 10 mg tablet1.37USD tablet
Metaglip 5-500 mg tablet1.33USD tablet
Metaglip 2.5-500 mg tablet1.32USD tablet
Metaglip 2.5-250 mg tablet1.2USD tablet
Glucotrol 10 mg tablet1.19USD tablet
Glucotrol XL 2.5 mg 24 Hour tablet0.99USD tablet
Glucotrol XL 5 mg 24 Hour tablet0.99USD tablet
GlipiZIDE XL 10 mg 24 Hour tablet0.84USD tablet
Glucotrol 5 mg tablet0.69USD tablet
Glucotrol xl 2.5 mg tablet0.69USD tablet
Glucotrol xl 5 mg tablet0.69USD tablet
Glipizide 10 mg tablet0.67USD tablet
GlipiZIDE XL 2.5 mg 24 Hour tablet0.63USD tablet
GlipiZIDE XL 5 mg 24 Hour tablet0.5USD tablet
Glipizide 5 mg tablet0.36USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2024502 No1997-11-112010-08-31Canada
US5024843 No1992-09-052009-09-05Us
US5591454 No1994-01-072014-01-07Us
USRE44459 No1999-03-262019-03-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point200-203U.S. Patent 3,669,966.
water solubility37.2 mg/LNot Available
logP1.91HANSCH,C ET AL. (1995)
pKa5.9PANTEN,U ET AL. (1989)
Predicted Properties
PropertyValueSource
Water Solubility0.0164 mg/mLALOGPS
logP1.83ALOGPS
logP1.43ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)4.32ChemAxon
pKa (Strongest Basic)0.059ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area130.15 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity115.62 m3·mol-1ChemAxon
Polarizability47.64 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Suresh Kumar Gidwani, Purushottam Singnurkar, Prashant Kumar Tewari, “Sustained release pharmaceutical composition containing glipizide and method for producing same.” U.S. Patent US6270797, issued February, 2000.

US6270797
General ReferencesNot Available
External Links
ATC CodesA10BB07
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (48.8 KB)
MSDSDownload (73.6 KB)
Interactions
Drug Interactions
Drug
7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE may increase the hypoglycemic activities of Glipizide.
AbirateroneThe metabolism of Glipizide can be decreased when combined with Abiraterone.
AcarboseAcarbose may increase the hypoglycemic activities of Glipizide.
AcebutololAcebutolol may increase the hypoglycemic activities of Glipizide.
AcenocoumarolGlipizide may increase the anticoagulant activities of Acenocoumarol.
AcetohexamideAcetohexamide may increase the hypoglycemic activities of Glipizide.
Acetylsalicylic acidAcetylsalicylic acid may increase the hypoglycemic activities of Glipizide.
AicarAicar may increase the hypoglycemic activities of Glipizide.
AlbiglutideAlbiglutide may increase the hypoglycemic activities of Glipizide.
AlogliptinAlogliptin may increase the hypoglycemic activities of Glipizide.
AlprenololAlprenolol may increase the hypoglycemic activities of Glipizide.
Aminosalicylic AcidAminosalicylic Acid may increase the hypoglycemic activities of Glipizide.
AmiodaroneThe metabolism of Glipizide can be decreased when combined with Amiodarone.
AmoxapineAmoxapine may increase the hypoglycemic activities of Glipizide.
AprepitantThe serum concentration of Glipizide can be increased when it is combined with Aprepitant.
AripiprazoleThe therapeutic efficacy of Glipizide can be decreased when used in combination with Aripiprazole.
ArotinololArotinolol may increase the hypoglycemic activities of Glipizide.
Arsenic trioxideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Arsenic trioxide.
ArticaineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Articaine.
AsenapineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Asenapine.
AtazanavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Atazanavir.
AtenololAtenolol may increase the hypoglycemic activities of Glipizide.
AtomoxetineThe metabolism of Glipizide can be decreased when combined with Atomoxetine.
AtorvastatinAtorvastatin may increase the hypoglycemic activities of Glipizide.
BefunololBefunolol may increase the hypoglycemic activities of Glipizide.
BendroflumethiazideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Bendroflumethiazide.
BenmoxinBenmoxin may increase the hypoglycemic activities of Glipizide.
BetamethasoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Betamethasone.
BetaxololBetaxolol may increase the hypoglycemic activities of Glipizide.
BevantololBevantolol may increase the hypoglycemic activities of Glipizide.
BexaroteneThe serum concentration of Glipizide can be decreased when it is combined with Bexarotene.
BezafibrateBezafibrate may increase the hypoglycemic activities of Glipizide.
BisoprololBisoprolol may increase the hypoglycemic activities of Glipizide.
BoceprevirThe metabolism of Glipizide can be decreased when combined with Boceprevir.
BopindololBopindolol may increase the hypoglycemic activities of Glipizide.
BortezomibThe metabolism of Glipizide can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Glipizide can be decreased when it is combined with Bosentan.
BrexpiprazoleThe therapeutic efficacy of Glipizide can be decreased when used in combination with Brexpiprazole.
BuforminBuformin may increase the hypoglycemic activities of Glipizide.
BufuralolBufuralol may increase the hypoglycemic activities of Glipizide.
BumetanideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Bumetanide.
BupranololBupranolol may increase the hypoglycemic activities of Glipizide.
BuserelinThe therapeutic efficacy of Glipizide can be decreased when used in combination with Buserelin.
CanagliflozinCanagliflozin may increase the hypoglycemic activities of Glipizide.
CapecitabineThe metabolism of Glipizide can be decreased when combined with Capecitabine.
CarbamazepineThe metabolism of Glipizide can be increased when combined with Carbamazepine.
CarbocisteineThe risk or severity of adverse effects can be increased when Glipizide is combined with Carbocisteine.
CaroxazoneCaroxazone may increase the hypoglycemic activities of Glipizide.
CarteololCarteolol may increase the hypoglycemic activities of Glipizide.
CarvedilolCarvedilol may increase the hypoglycemic activities of Glipizide.
CastanospermineCastanospermine may increase the hypoglycemic activities of Glipizide.
CeliprololCeliprolol may increase the hypoglycemic activities of Glipizide.
CeritinibThe serum concentration of Glipizide can be increased when it is combined with Ceritinib.
ChloramphenicolThe metabolism of Glipizide can be decreased when combined with Chloramphenicol.
ChlorothiazideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Chlorothiazide.
ChlorpropamideChlorpropamide may increase the hypoglycemic activities of Glipizide.
ChlorthalidoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Chlorthalidone.
CholecalciferolThe metabolism of Glipizide can be decreased when combined with Cholecalciferol.
CiglitazoneCiglitazone may increase the hypoglycemic activities of Glipizide.
CimetidineThe serum concentration of Glipizide can be increased when it is combined with Cimetidine.
CiprofibrateCiprofibrate may increase the hypoglycemic activities of Glipizide.
CitalopramCitalopram may increase the hypoglycemic activities of Glipizide.
ClarithromycinThe serum concentration of Glipizide can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Glipizide can be decreased when combined with Clemastine.
ClofibrateClofibrate may increase the hypoglycemic activities of Glipizide.
ClomipramineClomipramine may increase the hypoglycemic activities of Glipizide.
ClotrimazoleThe metabolism of Glipizide can be decreased when combined with Clotrimazole.
ClozapineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Clozapine.
CobicistatThe metabolism of Glipizide can be decreased when combined with Cobicistat.
ColesevelamThe serum concentration of Glipizide can be decreased when it is combined with Colesevelam.
ConivaptanThe serum concentration of Glipizide can be increased when it is combined with Conivaptan.
CorticotropinThe therapeutic efficacy of Glipizide can be decreased when used in combination with Corticotropin.
Cortisone acetateThe therapeutic efficacy of Glipizide can be decreased when used in combination with Cortisone acetate.
CrizotinibThe metabolism of Glipizide can be decreased when combined with Crizotinib.
CyclosporineThe metabolism of Glipizide can be decreased when combined with Cyclosporine.
Cyproterone acetateThe therapeutic efficacy of Glipizide can be decreased when used in combination with Cyproterone acetate.
DabrafenibThe therapeutic efficacy of Glipizide can be decreased when used in combination with Dabrafenib.
DanazolThe therapeutic efficacy of Glipizide can be decreased when used in combination with Danazol.
DapoxetineDapoxetine may increase the hypoglycemic activities of Glipizide.
DarunavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Darunavir.
DasatinibThe serum concentration of Glipizide can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Glipizide can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Glipizide can be decreased when combined with Delavirdine.
DesogestrelThe therapeutic efficacy of Glipizide can be decreased when used in combination with Desogestrel.
DexamethasoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Dexamethasone.
DiazoxideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Diazoxide.
DicoumarolGlipizide may increase the anticoagulant activities of Dicoumarol.
DienogestThe therapeutic efficacy of Glipizide can be decreased when used in combination with Dienogest.
DiflunisalDiflunisal may increase the hypoglycemic activities of Glipizide.
DihydroergotamineThe metabolism of Glipizide can be decreased when combined with Dihydroergotamine.
DihydrotestosteroneDihydrotestosterone may increase the hypoglycemic activities of Glipizide.
DiltiazemThe metabolism of Glipizide can be decreased when combined with Diltiazem.
DisopyramideGlipizide may increase the hypoglycemic activities of Disopyramide.
DoxycyclineThe metabolism of Glipizide can be decreased when combined with Doxycycline.
DronedaroneThe metabolism of Glipizide can be decreased when combined with Dronedarone.
DrospirenoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Drospirenone.
DulaglutideDulaglutide may increase the hypoglycemic activities of Glipizide.
EfavirenzThe serum concentration of Glipizide can be decreased when it is combined with Efavirenz.
EmpagliflozinEmpagliflozin may increase the hypoglycemic activities of Glipizide.
EnzalutamideThe serum concentration of Glipizide can be decreased when it is combined with Enzalutamide.
EpinephrineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Epinephrine.
ErythromycinThe metabolism of Glipizide can be decreased when combined with Erythromycin.
EscitalopramEscitalopram may increase the hypoglycemic activities of Glipizide.
Eslicarbazepine acetateThe serum concentration of Glipizide can be decreased when it is combined with Eslicarbazepine acetate.
EsmololEsmolol may increase the hypoglycemic activities of Glipizide.
EstradiolThe therapeutic efficacy of Glipizide can be decreased when used in combination with Estradiol.
Estrone sulfateThe therapeutic efficacy of Glipizide can be decreased when used in combination with Estrone sulfate.
Etacrynic acidThe therapeutic efficacy of Glipizide can be decreased when used in combination with Etacrynic acid.
EthanolThe risk or severity of adverse effects can be increased when Glipizide is combined with Ethanol.
Ethinyl EstradiolThe therapeutic efficacy of Glipizide can be decreased when used in combination with Ethinyl Estradiol.
Ethyl biscoumacetateGlipizide may increase the anticoagulant activities of Ethyl biscoumacetate.
Ethynodiol diacetateThe therapeutic efficacy of Glipizide can be decreased when used in combination with Ethynodiol diacetate.
EtofibrateEtofibrate may increase the hypoglycemic activities of Glipizide.
EtonogestrelThe therapeutic efficacy of Glipizide can be decreased when used in combination with Etonogestrel.
EtoperidoneEtoperidone may increase the hypoglycemic activities of Glipizide.
EtravirineThe serum concentration of Glipizide can be decreased when it is combined with Etravirine.
EverolimusThe therapeutic efficacy of Glipizide can be decreased when used in combination with Everolimus.
ExenatideExenatide may increase the hypoglycemic activities of Glipizide.
FenfluramineFenfluramine may increase the hypoglycemic activities of Glipizide.
FenofibrateFenofibrate may increase the hypoglycemic activities of Glipizide.
FloxuridineThe metabolism of Glipizide can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Glipizide can be decreased when combined with Fluconazole.
FludrocortisoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Fludrocortisone.
FluorouracilThe metabolism of Glipizide can be decreased when combined with Fluorouracil.
FluoxetineFluoxetine may increase the hypoglycemic activities of Glipizide.
FluoxymesteroneFluoxymesterone may increase the hypoglycemic activities of Glipizide.
FluvastatinThe metabolism of Glipizide can be decreased when combined with Fluvastatin.
FluvoxamineFluvoxamine may increase the hypoglycemic activities of Glipizide.
FosamprenavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Fosamprenavir.
FosaprepitantThe serum concentration of Glipizide can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Glipizide can be increased when combined with Fosphenytoin.
FurazolidoneFurazolidone may increase the hypoglycemic activities of Glipizide.
FurosemideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Furosemide.
Fusidic AcidThe serum concentration of Glipizide can be increased when it is combined with Fusidic Acid.
GemfibrozilGemfibrozil may increase the hypoglycemic activities of Glipizide.
GlibornurideGlibornuride may increase the hypoglycemic activities of Glipizide.
GliclazideGlipizide may increase the hypoglycemic activities of Gliclazide.
GlimepirideGlimepiride may increase the hypoglycemic activities of Glipizide.
GliquidoneGliquidone may increase the hypoglycemic activities of Glipizide.
GlyburideGlyburide may increase the hypoglycemic activities of Glipizide.
GoserelinThe therapeutic efficacy of Glipizide can be decreased when used in combination with Goserelin.
HistrelinThe therapeutic efficacy of Glipizide can be decreased when used in combination with Histrelin.
HydracarbazineHydracarbazine may increase the hypoglycemic activities of Glipizide.
HydrochlorothiazideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Hydrochlorothiazide.
HydrocortisoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Hydrocortisone.
HydroflumethiazideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Hydroflumethiazide.
Hydroxyprogesterone caproateThe therapeutic efficacy of Glipizide can be decreased when used in combination with Hydroxyprogesterone caproate.
IdelalisibThe serum concentration of Glipizide can be increased when it is combined with Idelalisib.
IloperidoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Iloperidone.
ImatinibThe metabolism of Glipizide can be decreased when combined with Imatinib.
IndalpineIndalpine may increase the hypoglycemic activities of Glipizide.
IndapamideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Indapamide.
IndenololIndenolol may increase the hypoglycemic activities of Glipizide.
IndinavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Indinavir.
Insulin AspartGlipizide may increase the hypoglycemic activities of Insulin Aspart.
Insulin DetemirGlipizide may increase the hypoglycemic activities of Insulin Detemir.
Insulin GlargineInsulin Glargine may increase the hypoglycemic activities of Glipizide.
Insulin GlulisineGlipizide may increase the hypoglycemic activities of Insulin Glulisine.
Insulin HumanGlipizide may increase the hypoglycemic activities of Insulin Human.
Insulin LisproInsulin Lispro may increase the hypoglycemic activities of Glipizide.
Insulin PorkInsulin Pork may increase the hypoglycemic activities of Glipizide.
IproclozideIproclozide may increase the hypoglycemic activities of Glipizide.
IproniazidIproniazid may increase the hypoglycemic activities of Glipizide.
IrbesartanThe metabolism of Glipizide can be decreased when combined with Irbesartan.
IsavuconazoniumThe metabolism of Glipizide can be decreased when combined with Isavuconazonium.
IsocarboxazidIsocarboxazid may increase the hypoglycemic activities of Glipizide.
IsradipineThe metabolism of Glipizide can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Glipizide can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Glipizide can be increased when it is combined with Ivacaftor.
KetoconazoleThe metabolism of Glipizide can be decreased when combined with Ketoconazole.
LabetalolLabetalol may increase the hypoglycemic activities of Glipizide.
LanreotideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Lanreotide.
LanreotideGlipizide may increase the hypoglycemic activities of Lanreotide.
LeflunomideThe metabolism of Glipizide can be decreased when combined with Leflunomide.
LeuprolideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Leuprolide.
LevobunololLevobunolol may increase the hypoglycemic activities of Glipizide.
LevomilnacipranLevomilnacipran may increase the hypoglycemic activities of Glipizide.
LevonorgestrelThe therapeutic efficacy of Glipizide can be decreased when used in combination with Levonorgestrel.
LinagliptinLinagliptin may increase the hypoglycemic activities of Glipizide.
Lipoic AcidLipoic Acid may increase the hypoglycemic activities of Glipizide.
LiraglutideLiraglutide may increase the hypoglycemic activities of Glipizide.
LopinavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Lopinavir.
LosartanThe metabolism of Glipizide can be decreased when combined with Losartan.
LovastatinThe metabolism of Glipizide can be decreased when combined with Lovastatin.
Lu AA21004Lu AA21004 may increase the hypoglycemic activities of Glipizide.
LuliconazoleThe serum concentration of Glipizide can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Glipizide can be decreased when it is combined with Lumacaftor.
LurasidoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Lurasidone.
MebanazineMebanazine may increase the hypoglycemic activities of Glipizide.
MecaserminGlipizide may increase the hypoglycemic activities of Mecasermin.
Medroxyprogesterone acetateThe therapeutic efficacy of Glipizide can be decreased when used in combination with Medroxyprogesterone acetate.
Megestrol acetateThe therapeutic efficacy of Glipizide can be decreased when used in combination with Megestrol acetate.
MesalazineMesalazine may increase the hypoglycemic activities of Glipizide.
MestranolThe therapeutic efficacy of Glipizide can be decreased when used in combination with Mestranol.
MetforminMetformin may increase the hypoglycemic activities of Glipizide.
MethotrimeprazineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Methotrimeprazine.
MethyclothiazideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Methyclothiazide.
Methylene blueMethylene blue may increase the hypoglycemic activities of Glipizide.
MethylprednisoloneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Methylprednisolone.
MethyltestosteroneMethyltestosterone may increase the hypoglycemic activities of Glipizide.
MetipranololMetipranolol may increase the hypoglycemic activities of Glipizide.
MetolazoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Metolazone.
MetoprololMetoprolol may increase the hypoglycemic activities of Glipizide.
MetreleptinMetreleptin may increase the hypoglycemic activities of Glipizide.
MiconazoleMiconazole may increase the hypoglycemic activities of Glipizide.
MifepristoneGlipizide may increase the hypoglycemic activities of Mifepristone.
MiglitolMiglitol may increase the hypoglycemic activities of Glipizide.
MiglustatMiglustat may increase the hypoglycemic activities of Glipizide.
MilnacipranMilnacipran may increase the hypoglycemic activities of Glipizide.
MinaprineMinaprine may increase the hypoglycemic activities of Glipizide.
MitiglinideMitiglinide may increase the hypoglycemic activities of Glipizide.
MitotaneThe serum concentration of Glipizide can be decreased when it is combined with Mitotane.
MoclobemideMoclobemide may increase the hypoglycemic activities of Glipizide.
ModafinilThe serum concentration of Glipizide can be decreased when it is combined with Modafinil.
NadololNadolol may increase the hypoglycemic activities of Glipizide.
NafcillinThe serum concentration of Glipizide can be decreased when it is combined with Nafcillin.
NateglinideNateglinide may increase the hypoglycemic activities of Glipizide.
NefazodoneThe metabolism of Glipizide can be decreased when combined with Nefazodone.
NelfinavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Nelfinavir.
NetupitantThe serum concentration of Glipizide can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Glipizide can be decreased when combined with Nevirapine.
NiacinThe therapeutic efficacy of Glipizide can be decreased when used in combination with Niacin.
NialamideNialamide may increase the hypoglycemic activities of Glipizide.
NicardipineThe metabolism of Glipizide can be decreased when combined with Nicardipine.
NilotinibThe therapeutic efficacy of Glipizide can be decreased when used in combination with Nilotinib.
NorethisteroneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Norethisterone.
NorgestimateThe therapeutic efficacy of Glipizide can be decreased when used in combination with Norgestimate.
OctamoxinOctamoxin may increase the hypoglycemic activities of Glipizide.
OctreotideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Octreotide.
OctreotideGlipizide may increase the hypoglycemic activities of Octreotide.
OlanzapineOlanzapine may increase the hypoglycemic activities of Glipizide.
OlaparibThe metabolism of Glipizide can be decreased when combined with Olaparib.
OmeprazoleThe metabolism of Glipizide can be decreased when combined with Omeprazole.
OsimertinibThe serum concentration of Glipizide can be increased when it is combined with Osimertinib.
OxandroloneOxandrolone may increase the hypoglycemic activities of Glipizide.
OxprenololOxprenolol may increase the hypoglycemic activities of Glipizide.
OxymetholoneOxymetholone may increase the hypoglycemic activities of Glipizide.
PalbociclibThe serum concentration of Glipizide can be increased when it is combined with Palbociclib.
PaliperidoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Paliperidone.
PargylinePargyline may increase the hypoglycemic activities of Glipizide.
ParoxetineParoxetine may increase the hypoglycemic activities of Glipizide.
PasireotideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Pasireotide.
PasireotideGlipizide may increase the hypoglycemic activities of Pasireotide.
PegvisomantPegvisomant may increase the hypoglycemic activities of Glipizide.
PenbutololPenbutolol may increase the hypoglycemic activities of Glipizide.
PentamidineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Pentamidine.
PentamidineGlipizide may increase the hypoglycemic activities of Pentamidine.
PentobarbitalThe metabolism of Glipizide can be increased when combined with Pentobarbital.
PhenelzinePhenelzine may increase the hypoglycemic activities of Glipizide.
PhenforminPhenformin may increase the hypoglycemic activities of Glipizide.
PhenindioneGlipizide may increase the anticoagulant activities of Phenindione.
PheniprazinePheniprazine may increase the hypoglycemic activities of Glipizide.
PhenobarbitalThe metabolism of Glipizide can be increased when combined with Phenobarbital.
PhenoxypropazinePhenoxypropazine may increase the hypoglycemic activities of Glipizide.
PhenprocoumonGlipizide may increase the anticoagulant activities of Phenprocoumon.
PhenytoinThe metabolism of Glipizide can be increased when combined with Phenytoin.
PindololPindolol may increase the hypoglycemic activities of Glipizide.
PioglitazonePioglitazone may increase the hypoglycemic activities of Glipizide.
PiperazineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Piperazine.
PipotiazineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Pipotiazine.
PirlindolePirlindole may increase the hypoglycemic activities of Glipizide.
PivhydrazinePivhydrazine may increase the hypoglycemic activities of Glipizide.
PolythiazideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Polythiazide.
PosaconazolePosaconazole may increase the hypoglycemic activities of Glipizide.
PractololPractolol may increase the hypoglycemic activities of Glipizide.
PramlintidePramlintide may increase the hypoglycemic activities of Glipizide.
PrednisoloneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Prednisolone.
PrednisoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Prednisone.
PrimidoneThe metabolism of Glipizide can be increased when combined with Primidone.
ProbenecidThe protein binding of Glipizide can be decreased when combined with Probenecid.
ProgesteroneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Progesterone.
PropranololPropranolol may increase the hypoglycemic activities of Glipizide.
PyrimethamineThe metabolism of Glipizide can be decreased when combined with Pyrimethamine.
QuetiapineThe therapeutic efficacy of Glipizide can be decreased when used in combination with Quetiapine.
QuinethazoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Quinethazone.
QuinineGlipizide may increase the hypoglycemic activities of Quinine.
RanitidineThe serum concentration of Glipizide can be increased when it is combined with Ranitidine.
RanolazineThe metabolism of Glipizide can be decreased when combined with Ranolazine.
RasagilineRasagiline may increase the hypoglycemic activities of Glipizide.
RepaglinideRepaglinide may increase the hypoglycemic activities of Glipizide.
RifabutinThe metabolism of Glipizide can be increased when combined with Rifabutin.
RifampicinThe serum concentration of Glipizide can be decreased when it is combined with Rifampicin.
RifapentineThe metabolism of Glipizide can be increased when combined with Rifapentine.
RisperidoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Risperidone.
RitonavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Ritonavir.
RosiglitazoneRosiglitazone may increase the hypoglycemic activities of Glipizide.
SafrazineSafrazine may increase the hypoglycemic activities of Glipizide.
Salicylic acidSalicylic acid may increase the hypoglycemic activities of Glipizide.
SaquinavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Saquinavir.
SaxagliptinSaxagliptin may increase the hypoglycemic activities of Glipizide.
SecobarbitalThe metabolism of Glipizide can be increased when combined with Secobarbital.
SelegilineSelegiline may increase the hypoglycemic activities of Glipizide.
SertralineSertraline may increase the hypoglycemic activities of Glipizide.
SildenafilThe metabolism of Glipizide can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Glipizide can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Glipizide can be increased when it is combined with Simeprevir.
SirolimusThe therapeutic efficacy of Glipizide can be decreased when used in combination with Sirolimus.
SitagliptinSitagliptin may increase the hypoglycemic activities of Glipizide.
SorafenibThe metabolism of Glipizide can be decreased when combined with Sorafenib.
SotalolSotalol may increase the hypoglycemic activities of Glipizide.
St. John's WortThe serum concentration of Glipizide can be decreased when it is combined with St. John's Wort.
StanozololStanozolol may increase the hypoglycemic activities of Glipizide.
StiripentolThe serum concentration of Glipizide can be increased when it is combined with Stiripentol.
SulfadiazineSulfadiazine may increase the hypoglycemic activities of Glipizide.
SulfamethoxazoleSulfamethoxazole may increase the hypoglycemic activities of Glipizide.
SulfisoxazoleSulfisoxazole may increase the hypoglycemic activities of Glipizide.
SulodexideSulodexide may increase the hypoglycemic activities of Glipizide.
SunitinibGlipizide may increase the hypoglycemic activities of Sunitinib.
TacrolimusThe therapeutic efficacy of Glipizide can be decreased when used in combination with Tacrolimus.
TelaprevirThe metabolism of Glipizide can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Glipizide can be decreased when combined with Telithromycin.
TemsirolimusThe therapeutic efficacy of Glipizide can be decreased when used in combination with Temsirolimus.
TestosteroneTestosterone may increase the hypoglycemic activities of Glipizide.
TicagrelorThe metabolism of Glipizide can be decreased when combined with Ticagrelor.
TiclopidineThe metabolism of Glipizide can be decreased when combined with Ticlopidine.
TimololTimolol may increase the hypoglycemic activities of Glipizide.
TipranavirThe therapeutic efficacy of Glipizide can be decreased when used in combination with Tipranavir.
TocilizumabThe serum concentration of Glipizide can be decreased when it is combined with Tocilizumab.
TolazamideTolazamide may increase the hypoglycemic activities of Glipizide.
TolbutamideGlipizide may increase the hypoglycemic activities of Tolbutamide.
ToloxatoneToloxatone may increase the hypoglycemic activities of Glipizide.
TorasemideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Torasemide.
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypoglycemic activities of Glipizide.
TranylcypromineTranylcypromine may increase the hypoglycemic activities of Glipizide.
TrazodoneTrazodone may increase the hypoglycemic activities of Glipizide.
TriamcinoloneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Triamcinolone.
TrichlormethiazideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Trichlormethiazide.
TrimethoprimThe metabolism of Glipizide can be decreased when combined with Trimethoprim.
TriptorelinThe therapeutic efficacy of Glipizide can be decreased when used in combination with Triptorelin.
TroglitazoneTroglitazone may increase the hypoglycemic activities of Glipizide.
Valproic AcidThe metabolism of Glipizide can be decreased when combined with Valproic Acid.
ValsartanThe metabolism of Glipizide can be decreased when combined with Valsartan.
VenlafaxineThe metabolism of Glipizide can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Glipizide can be decreased when combined with Verapamil.
VilazodoneVilazodone may increase the hypoglycemic activities of Glipizide.
VildagliptinVildagliptin may increase the hypoglycemic activities of Glipizide.
VogliboseVoglibose may increase the hypoglycemic activities of Glipizide.
VoriconazoleThe serum concentration of Glipizide can be increased when it is combined with Voriconazole.
VorinostatThe therapeutic efficacy of Glipizide can be decreased when used in combination with Vorinostat.
VortioxetineVortioxetine may increase the hypoglycemic activities of Glipizide.
WarfarinGlipizide may increase the anticoagulant activities of Warfarin.
ZafirlukastThe metabolism of Glipizide can be decreased when combined with Zafirlukast.
ZimelidineZimelidine may increase the hypoglycemic activities of Glipizide.
ZiprasidoneThe therapeutic efficacy of Glipizide can be decreased when used in combination with Ziprasidone.
Food Interactions
  • Avoid alcohol.
  • Avoid sugar and sugary food.
  • Take 30-60 minutes before breakfast.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Sulfonylurea receptor activity
Specific Function:
Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release.
Gene Name:
ABCC8
Uniprot ID:
Q09428
Molecular Weight:
176990.36 Da
References
  1. Gribble FM, Ashcroft FM: Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues. Metabolism. 2000 Oct;49(10 Suppl 2):3-6. [PubMed:11078468 ]
  2. Harrower A: Gliclazide modified release: from once-daily administration to 24-hour blood glucose control. Metabolism. 2000 Oct;49(10 Suppl 2):7-11. [PubMed:11078469 ]
  3. Lawrence CL, Proks P, Rodrigo GC, Jones P, Hayabuchi Y, Standen NB, Ashcroft FM: Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia. 2001 Aug;44(8):1019-25. [PubMed:11484080 ]
  4. Reimann F, Ashcroft FM, Gribble FM: Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9. [PubMed:11574406 ]
  5. Proks P, Reimann F, Green N, Gribble F, Ashcroft F: Sulfonylurea stimulation of insulin secretion. Diabetes. 2002 Dec;51 Suppl 3:S368-76. [PubMed:12475777 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation...
Gene Name:
PPARG
Uniprot ID:
P37231
Molecular Weight:
57619.58 Da
References
  1. Scarsi M, Podvinec M, Roth A, Hug H, Kersten S, Albrecht H, Schwede T, Meyer UA, Rucker C: Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach. Mol Pharmacol. 2007 Feb;71(2):398-406. Epub 2006 Nov 2. [PubMed:17082235 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
comments powered by Disqus
Drug created on June 13, 2005 07:24 / Updated on August 30, 2016 02:11