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Identification
NameGlipizide
Accession NumberDB01067  (APRD00436)
TypeSmall Molecule
GroupsApproved
Description

An oral hypoglycemic agent which is rapidly absorbed and completely metabolized. [PubChem]

Structure
Thumb
Synonyms
1-Cyclohexyl-3-({p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl}sulfonyl)urea
Aldiab
CP 28,720
CP 28720
CP-28,720
Digrin
Dipazide
Glibenese
Glibetin
Glican
Glidiab
Glipid
Glipizida
Glipizidum
Gluco-rite
Glucolip
Glucotrol
Glucozide
Glupitel
Glupizide
Glyde
Glydiazinamide
K 4024
Melizide
Mindiab
Minidab
Minidiab
Minodiab
N-{4-[beta-(5-methylpyrazine-2-carboxamido)ethyl]benzenesulphonyl}-n'-cyclohexylurea
Napizide
Ozidia
Sucrazide
External Identifiers Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Glipizidetablet, extended release5 mg/1oralREMEDYREPACK INC.2011-12-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, extended release10 mg/1oralCardinal Health1994-04-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release2.5 mg/1oralCardinal Health1994-04-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release5 mg/1oralSt Marys Medical Park Pharmacy2014-05-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release10 mg/1oralGreenstone LLC2004-06-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release5 mg/1oralGreenstone LLC2004-06-112017-03-31Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release10 mg/1oralGreenstone LLC2013-05-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release10 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release5 mg/1oralGreenstone LLC2013-05-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release2.5 mg/1oralGreenstone LLC2013-05-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide XLtablet, extended release2.5 mg/1oralCardinal Health1994-04-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotroltablet10 mg/1oralPd Rx Pharmaceuticals, Inc.1984-05-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotroltablet10 mg/1oralRoerig1984-05-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotroltablet5 mg/1oralRoerig1984-05-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotrol XLtablet, extended release2.5 mg/1oralRoerig2013-07-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotrol XLtablet, extended release2.5 mg/1oralPhysicians Total Care, Inc.2003-05-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotrol XLtablet, extended release5 mg/1oralPhysicians Total Care, Inc.1994-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotrol XLtablet, extended release10 mg/1oralRoerig1999-04-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotrol XLtablet, extended release10 mg/1oralPhysicians Total Care, Inc.1994-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotrol XLtablet, extended release5 mg/1oralRoerig1994-04-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotrol XLtablet, extended release10 mg/1oralRoerig2013-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glucotrol XLtablet, extended release5 mg/1oralRoerig2013-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Glipizidetablet, extended release2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release10 mg/1oralPar Pharmaceutical, Inc.2013-09-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralContract Pharmacy Services Pa2010-04-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release2.5 mg/1oralPhysicians Total Care, Inc.2005-07-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralSt Marys Medical Park Pharmacy2013-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralMylan Institutional Inc.1994-07-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralLegacy Pharmaceutical Packaging, Llc1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralProficient Rx LP2011-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralMylan Pharmaceuticals Inc.1994-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralBlenheim Pharmacal, Inc.2010-09-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2011-09-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralMc Kesson Contract Packaging2011-11-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralGolden State Medical Supply Inc.2012-09-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralTYA Pharmaceuticals2011-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1994-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralAccord Healthcare Inc.2011-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralPhysicians Total Care, Inc.1994-11-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2013-05-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralProficient Rx LP1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralMylan Pharmaceuticals Inc.1994-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralMylan Institutional Inc.1994-07-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralMc Kesson Contract Packaging2011-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralGolden State Medical Supply Inc.2012-09-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1994-05-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralAccord Healthcare Inc.2011-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralPhysicians Total Care, Inc.1994-07-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2013-05-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2011-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release10 mg/1oralMylan Pharmaceuticals Inc.2015-10-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralUnit Dose Services1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralClinical Solutions Wholesale1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralSTAT Rx USA LLC1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2013-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release5 mg/1oralREMEDYREPACK INC.2011-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release5 mg/1oralMylan Pharmaceuticals Inc.2015-10-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralUpsher Smith Laboratories, Inc.2015-03-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralUnit Dose Services1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralSTAT Rx USA LLC1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2013-01-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2011-04-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralPreferred Pharmaceuticals,Inc.2011-04-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralClinical Solutions Wholesale1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2014-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release2.5 mg/1oralMylan Pharmaceuticals Inc.2015-10-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralUpsher Smith Laboratories, Inc.2015-03-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralH.J. Harkins Company, Inc.1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralAidarex Pharmaceuticals LLC2002-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralBlenheim Pharmacal, Inc.2013-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2012-09-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2011-04-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2013-02-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralClinical Solutions Wholesale1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralbryant ranch prepack1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralSandoz Inc1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2014-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralAidarex Pharmaceuticals LLC2002-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralAphena Pharma Solutions Tennessee, Llc1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralCardinal Health2010-11-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2014-09-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralBlenheim Pharmacal, Inc.2013-09-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralNorthwind Pharmaceuticals2014-12-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2010-11-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2013-02-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralSun Pharmaceutical Industries, Inc.2009-07-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralbryant ranch prepack1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralWatson Laboratories, Inc.1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release5 mg/1oralPhysicians Total Care, Inc.2005-01-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2013-10-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release5 mg/1oralPar Pharmaceutical, Inc.2013-09-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralIVAX Pharmaceuticals Inc.1995-08-312015-11-30Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralApotex Corp.2002-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, extended release5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralRebel Distributors Corp1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralSandoz Inc1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2014-06-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2011-05-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralAphena Pharma Solutions Tennessee, Llc1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralCardinal Health2010-11-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralSt Marys Medical Park Pharmacy2013-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralNorthwind Pharmaceuticals2014-12-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralLegacy Pharmaceutical Packaging, Llc1995-04-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralSun Pharmaceutical Industries, Inc.2009-07-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralProficient Rx LP2011-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralWatson Laboratories, Inc.1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralBlenheim Pharmacal, Inc.2012-01-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, film coated, extended release10 mg/1oralPhysicians Total Care, Inc.2004-01-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralREMEDYREPACK INC.2013-03-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralREMEDYREPACK INC.2011-05-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralIVAX Pharmaceuticals Inc.1995-09-122015-10-31Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralApotex Corp.2002-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet10 mg/1oralMed Vantx, Inc.2012-03-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet, extended release10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizidetablet5 mg/1oralRebel Distributors Corp1995-02-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release2.5 mg/1oralRebel Distributors Corp2006-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release2.5 mg/1oralAvera Mc Kennan Hospital2015-11-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, extended release2.5 mg/1oralActavis Elizabeth LLC2003-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release10 mg/1oralCarilion Materials Management2003-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release10 mg/1oralPar Pharmaceuticals, Inc.2015-07-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release2.5 mg/1oralbryant ranch prepack2006-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release2.5 mg/1oralAmerican Health Packaging2008-10-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release10 mg/1oralDIRECT RX2015-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release5 mg/1oralPar Pharmaceuticals, Inc.2015-07-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release5 mg/1oralbryant ranch prepack2003-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release2.5 mg/1oralWatson Laboratories, Inc.2006-04-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release10 mg/1oralAmerican Health Packaging2008-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release10 mg/1oralWatson Laboratories, Inc.2003-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release5 mg/1oralUnit Dose Services2003-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release5 mg/1oralAmerican Health Packaging2008-06-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release10 mg/1oralPd Rx Pharmaceuticals, Inc.2003-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release5 mg/1oralWatson Laboratories, Inc.2003-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, extended release10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, extended release10 mg/1oralActavis Elizabeth LLC2003-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release5 mg/1oralDispensing Solutions, Inc.2003-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, extended release5 mg/1oralActavis Elizabeth LLC2003-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizide ERtablet, film coated, extended release10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizideertablet, film coated, extended release10 mg/1oralbryant ranch prepack2003-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizideer ERtablet, film coated, extended release2.5 mg/1oralREMEDYREPACK INC.2013-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizideer ERtablet, film coated, extended release10 mg/1oralAidarex Pharmaceuticals LLC2003-11-07Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizideer ERtablet, film coated, extended release5 mg/1oralPd Rx Pharmaceuticals, Inc.2003-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizideer ERtablet, film coated, extended release5 mg/1oralAidarex Pharmaceuticals LLC2003-11-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Glipizideer ERtablet, film coated, extended release10 mg/1oralREMEDYREPACK INC.2013-11-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter ProductsNot Available
International Brands
NameCompany
GlibenesePfizer
GlibénèseDexo
GlibetinJohnson
GlipinSwiss Pharm
GlixYSP
MindiabPfizer
MinidiabPfizer
Zitrol XRSquare
Brand mixtures
NameLabellerIngredients
Glipizide and Metformin HClHeritage Pharmaceuticals Inc.
Glipizide and Metformin HydrochlorideTeva Pharmaceuticals USA Inc
SaltsNot Available
Categories
UNIIX7WDT95N5C
CAS number29094-61-9
WeightAverage: 445.535
Monoisotopic: 445.178375067
Chemical FormulaC21H27N5O4S
InChI KeyInChIKey=ZJJXGWJIGJFDTL-UHFFFAOYSA-N
InChI
InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
IUPAC Name
N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-5-methylpyrazine-2-carboxamide
SMILES
CC1=CN=C(C=N1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzenesulfonamides
Direct ParentBenzenesulfonamides
Alternative Parents
Substituents
  • Benzenesulfonamide
  • Pyrazinecarboxamide
  • Pyrazine carboxylic acid or derivatives
  • Phenethylamine
  • Sulfonylurea
  • Cyclohexylamine
  • Pyrazine
  • Heteroaromatic compound
  • Aminosulfonyl compound
  • Sulfonyl
  • Sulfonic acid derivative
  • Sulfonamide
  • Secondary carboxylic acid amide
  • Carboxamide group
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor use as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM; type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory.
PharmacodynamicsGlipizide, a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II. The primary mode of action of glipizide in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet tissue and is thus dependent on functioning beta cells in the pancreatic islets. In humans glipizide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. In man, stimulation of insulin secretion by glipizide in response to a meal is undoubtedly of major importance. Fasting insulin levels are not elevated even on long-term glipizide administration, but the postprandial insulin response continues to be enhanced after at least 6 months of treatment. Some patients fail to respond initially, or gradually lose their responsiveness to sulfonylurea drugs, including glipizide.
Mechanism of actionSulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
AbsorptionGastrointestinal absorption is uniform, rapid, and essentially complete.
Volume of distribution
  • 11 L
Protein binding98-99%, primarily to albumin.
Metabolism

Hepatic. The major metabolites of glipizide are products of aromatic hydroxylation and have no hypoglycemic activity. A minor metabolite which accounts for less than 2% of a dose, an acetylaminoethyl benzine derivatives, is reported to have 1/10 to 1/3 as much hypoglycemic activity as the parent compound.

SubstrateEnzymesProduct
Glipizide
Not Available
3-cis-HydroxyglipizideDetails
Glipizide
4-trans-HydroxyglipizideDetails
Route of eliminationThe primary metabolites are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine.
Half life2-5 hours
ClearanceNot Available
ToxicityThe acute oral toxicity was extremely low in all species tested (LD50 greater than 4 g/kg). Overdosage of sulfonylureas including glipizide can produce hypoglycemia.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated Effects
Interacting Gene/EnzymeSNP RS IDAllele nameDefining changeEffectReference(s)
Cytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
rs1057910 CYP2C9*1C AllelePoor drug metabolizer, lower dose requirements10208645
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9262
Blood Brain Barrier+0.5599
Caco-2 permeable-0.7025
P-glycoprotein substrateSubstrate0.5326
P-glycoprotein inhibitor INon-inhibitor0.7469
P-glycoprotein inhibitor IINon-inhibitor0.9302
Renal organic cation transporterNon-inhibitor0.8322
CYP450 2C9 substrateSubstrate0.5731
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.719
CYP450 1A2 substrateNon-inhibitor0.9501
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testNon AMES toxic0.7745
CarcinogenicityNon-carcinogens0.826
BiodegradationNot ready biodegradable0.9703
Rat acute toxicity2.1662 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9118
hERG inhibition (predictor II)Non-inhibitor0.8539
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, film coated, extended releaseoral10 mg/1
Tablet, film coated, extended releaseoral2.5 mg/1
Tablet, film coated, extended releaseoral5 mg/1
Tablet, film coatedoral
Tabletoral10 mg/1
Tabletoral5 mg/1
Tablet, extended releaseoral10 mg/1
Tablet, extended releaseoral2.5 mg/1
Tablet, extended releaseoral5 mg/1
Prices
Unit descriptionCostUnit
Glipizide powder36.11USD g
Glucotrol XL 10 mg 24 Hour tablet1.53USD tablet
Glucotrol xl 10 mg tablet1.37USD tablet
Metaglip 5-500 mg tablet1.33USD tablet
Metaglip 2.5-500 mg tablet1.32USD tablet
Metaglip 2.5-250 mg tablet1.2USD tablet
Glucotrol 10 mg tablet1.19USD tablet
Glucotrol XL 2.5 mg 24 Hour tablet0.99USD tablet
Glucotrol XL 5 mg 24 Hour tablet0.99USD tablet
GlipiZIDE XL 10 mg 24 Hour tablet0.84USD tablet
Glucotrol 5 mg tablet0.69USD tablet
Glucotrol xl 2.5 mg tablet0.69USD tablet
Glucotrol xl 5 mg tablet0.69USD tablet
Glipizide 10 mg tablet0.67USD tablet
GlipiZIDE XL 2.5 mg 24 Hour tablet0.63USD tablet
GlipiZIDE XL 5 mg 24 Hour tablet0.5USD tablet
Glipizide 5 mg tablet0.36USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
CountryPatent NumberApprovedExpires (estimated)
Canada20245021997-11-112010-08-31
United States50248431992-09-052009-09-05
United States55914541994-01-072014-01-07
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point200-203U.S. Patent 3,669,966.
water solubility37.2 mg/LNot Available
logP1.91HANSCH,C ET AL. (1995)
pKa5.9PANTEN,U ET AL. (1989)
Predicted Properties
PropertyValueSource
Water Solubility0.0164 mg/mLALOGPS
logP1.83ALOGPS
logP1.43ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)4.32ChemAxon
pKa (Strongest Basic)0.059ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area130.15 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity115.62 m3·mol-1ChemAxon
Polarizability47.64 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Suresh Kumar Gidwani, Purushottam Singnurkar, Prashant Kumar Tewari, “Sustained release pharmaceutical composition containing glipizide and method for producing same.” U.S. Patent US6270797, issued February, 2000.

US6270797
General ReferencesNot Available
External Links
ATC CodesA10BB07
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (48.8 KB)
MSDSDownload (73.6 KB)
Interactions
Drug Interactions
Drug
AcetohexamideAcetohexamide may increase the hypoglycemic activities of Glipizide.
Acetylsalicylic acidAcetylsalicylic acid may increase the hypoglycemic activities of Glipizide.
AlogliptinAlogliptin may increase the hypoglycemic activities of Glipizide.
AmitriptylineAmitriptyline may increase the hypoglycemic activities of Glipizide.
CanagliflozinCanagliflozin may increase the hypoglycemic activities of Glipizide.
CarbocisteineThe risk or severity of adverse effects can be increased when Glipizide is combined with Carbocisteine.
CeritinibThe serum concentration of Glipizide can be increased when it is combined with Ceritinib.
ChloramphenicolThe metabolism of Glipizide can be decreased when combined with Chloramphenicol.
ChlorpropamideChlorpropamide may increase the hypoglycemic activities of Glipizide.
CimetidineThe serum concentration of Glipizide can be increased when it is combined with Cimetidine.
ClarithromycinThe serum concentration of Glipizide can be increased when it is combined with Clarithromycin.
ColesevelamThe serum concentration of Glipizide can be decreased when it is combined with Colesevelam.
DabrafenibThe serum concentration of Glipizide can be decreased when it is combined with Dabrafenib.
DexketoprofenThe risk or severity of adverse effects can be increased when Dexketoprofen is combined with Glipizide.
DicoumarolGlipizide may increase the anticoagulant activities of Dicoumarol.
DihydrotestosteroneDihydrotestosterone may increase the hypoglycemic activities of Glipizide.
EthanolThe risk or severity of adverse effects can be increased when Glipizide is combined with Ethanol.
ExenatideExenatide may increase the hypoglycemic activities of Glipizide.
FenofibrateFenofibrate may increase the hypoglycemic activities of Glipizide.
FloxuridineThe metabolism of Glipizide can be decreased when combined with Floxuridine.
FluconazoleThe metabolism of Glipizide can be decreased when combined with Fluconazole.
GliclazideGliclazide may increase the hypoglycemic activities of Glipizide.
GlimepirideGlimepiride may increase the hypoglycemic activities of Glipizide.
GliquidoneGliquidone may increase the hypoglycemic activities of Glipizide.
GlyburideGlyburide may increase the hypoglycemic activities of Glipizide.
Insulin AspartInsulin Aspart may increase the hypoglycemic activities of Glipizide.
Insulin DetemirInsulin Detemir may increase the hypoglycemic activities of Glipizide.
Insulin GlargineInsulin Glargine may increase the hypoglycemic activities of Glipizide.
Insulin GlulisineInsulin Glulisine may increase the hypoglycemic activities of Glipizide.
Insulin LisproInsulin Lispro may increase the hypoglycemic activities of Glipizide.
Insulin RegularInsulin Regular may increase the hypoglycemic activities of Glipizide.
Insulin, isophaneInsulin, isophane may increase the hypoglycemic activities of Glipizide.
LeuprolideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Leuprolide.
LinagliptinLinagliptin may increase the hypoglycemic activities of Glipizide.
Lipoic AcidLipoic Acid may increase the hypoglycemic activities of Glipizide.
LumacaftorThe serum concentration of Glipizide can be decreased when it is combined with Lumacaftor.
MecamylamineThe risk or severity of adverse effects can be increased when Glipizide is combined with Mecamylamine.
MetforminMetformin may increase the hypoglycemic activities of Glipizide.
MetreleptinMetreleptin may increase the hypoglycemic activities of Glipizide.
MiconazoleMiconazole may increase the hypoglycemic activities of Glipizide.
MifepristoneThe serum concentration of Glipizide can be increased when it is combined with Mifepristone.
NadololNadolol may increase the hypoglycemic activities of Glipizide.
OxandroloneOxandrolone may increase the hypoglycemic activities of Glipizide.
ParoxetineParoxetine may increase the hypoglycemic activities of Glipizide.
PegvisomantPegvisomant may increase the hypoglycemic activities of Glipizide.
PhenelzinePhenelzine may increase the hypoglycemic activities of Glipizide.
PhenytoinThe metabolism of Glipizide can be increased when combined with Phenytoin.
PorfimerGlipizide may increase the photosensitizing activities of Porfimer.
PosaconazolePosaconazole may increase the hypoglycemic activities of Glipizide.
ProbenecidThe protein binding of Glipizide can be decreased when combined with Probenecid.
RanitidineThe serum concentration of Glipizide can be increased when it is combined with Ranitidine.
RepaglinideRepaglinide may increase the hypoglycemic activities of Glipizide.
RifampicinThe serum concentration of Glipizide can be decreased when it is combined with Rifampicin.
Salicylate-sodiumSalicylate-sodium may increase the hypoglycemic activities of Glipizide.
SaxagliptinSaxagliptin may increase the hypoglycemic activities of Glipizide.
SecobarbitalThe metabolism of Glipizide can be increased when combined with Secobarbital.
SitagliptinSitagliptin may increase the hypoglycemic activities of Glipizide.
SparfloxacinSparfloxacin may increase the hypoglycemic activities of Glipizide.
SulfisoxazoleSulfisoxazole may increase the hypoglycemic activities of Glipizide.
TestosteroneTestosterone may increase the hypoglycemic activities of Glipizide.
TolbutamideTolbutamide may increase the hypoglycemic activities of Glipizide.
TranylcypromineTranylcypromine may increase the hypoglycemic activities of Glipizide.
TrichlormethiazideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Trichlormethiazide.
TroglitazoneTroglitazone may increase the hypoglycemic activities of Glipizide.
VerteporfinGlipizide may increase the photosensitizing activities of Verteporfin.
VildagliptinVildagliptin may increase the hypoglycemic activities of Glipizide.
VoriconazoleThe serum concentration of Glipizide can be increased when it is combined with Voriconazole.
Food Interactions
  • Avoid alcohol.
  • Avoid sugar and sugary food.
  • Take 30-60 minutes before breakfast.

Targets

1. ATP-binding cassette sub-family C member 8

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
ATP-binding cassette sub-family C member 8 Q09428 Details

References:

  1. Gribble FM, Ashcroft FM: Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues. Metabolism. 2000 Oct;49(10 Suppl 2):3-6. Pubmed
  2. Harrower A: Gliclazide modified release: from once-daily administration to 24-hour blood glucose control. Metabolism. 2000 Oct;49(10 Suppl 2):7-11. Pubmed
  3. Lawrence CL, Proks P, Rodrigo GC, Jones P, Hayabuchi Y, Standen NB, Ashcroft FM: Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia. 2001 Aug;44(8):1019-25. Pubmed
  4. Reimann F, Ashcroft FM, Gribble FM: Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9. Pubmed
  5. Proks P, Reimann F, Green N, Gribble F, Ashcroft F: Sulfonylurea stimulation of insulin secretion. Diabetes. 2002 Dec;51 Suppl 3:S368-76. Pubmed

2. Peroxisome proliferator-activated receptor gamma

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: agonist

Components

Name UniProt ID Details
Peroxisome proliferator-activated receptor gamma P37231 Details

References:

  1. Scarsi M, Podvinec M, Roth A, Hug H, Kersten S, Albrecht H, Schwede T, Meyer UA, Rucker C: Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach. Mol Pharmacol. 2007 Feb;71(2):398-406. Epub 2006 Nov 2. Pubmed

Enzymes

1. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. Pubmed

2. Cytochrome P450 3A4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 3A4 P08684 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on January 11, 2014 08:47