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Identification
NameMiconazole
Accession NumberDB01110  (APRD01115)
TypeSmall Molecule
GroupsApproved, Investigational, Vet Approved
Description

An imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]

Structure
Thumb
Synonyms
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
Daktarin iv
Miconazole
Monistat iv (tn)
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Oravigtablet50 mg/1buccalDara Bio Sciences, Inc.2012-11-01Not applicableUs
Oravigtablet50 mg/1buccalPraelia Pharmaceuticals Inc2012-11-012015-12-29Us
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Miconazole Nitratesuppository200 mg/1vaginalActavis Mid Atlantic LLC2002-09-03Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
3m Cavilon Antifungalcream2 g/1000gtopical3 M Health Care2010-11-30Not applicableUs
7 Day Vaginalcream2 g/100gtopicalCardinal Health2009-03-16Not applicableUs
Aloe Vesta Antifungalointment20 mg/gtopicalConva Tec, Inc.1997-10-03Not applicableUs
Aloe Vesta Clear Antifungalointment2 g/100gtopicalConvatec Inc.2013-12-20Not applicableUs
Anti-fungalcream.02 g/gtopicalUniversal Distribution Center LLC2015-04-15Not applicableUs
Antifungalcream20 mg/gtopicalPSS World Medical, Inc.2012-09-05Not applicableUs
Antifungalcream20 mg/gtopicalActavis Pharma, Inc.2007-05-01Not applicableUs
Antifungal Skin Care CvskitProduct Quest Mfg.2016-04-14Not applicableUs
Athlet Foot Well At Walgreenspowder2 g/100mLtopicalWalgreens2015-04-15Not applicableUs
Athletes Footspray2 g/100gtopicalWalgreen Company2005-06-09Not applicableUs
Athletes Footspray2 g/100gtopicalWalgreen Company2005-06-09Not applicableUs
Athletes Foot Sprayspray2 g/100gtopicalCVS Pharmacy2006-03-02Not applicableUs
Azolentincture20 mg/mLtopicalStratus Pharmaceuticals, Inc.2011-12-01Not applicableUs
Baza Antifungalcream20 mg/gtopicalColoplast Manufacturing US, LLC2009-06-15Not applicableUs
Bf-micozocream20 mg/gtopicalBright Future Pharmaceuticals Factory2011-03-08Not applicableUs
Budpak Antifungal Miconazole Nitratecream.02 g/gtopicalBudpak Inc.2013-11-29Not applicableUs
Care One Miconazole 1kitAmerican Sales Company2010-11-19Not applicableUs
Care One Miconazole 3kitAmerican Sales Company2004-07-27Not applicableUs
Care One Miconazole 7cream2 g/100gvaginalAmerican Sales Company1999-10-11Not applicableUs
Careone Miconazole 3kitAmerican Sales Company2014-04-13Not applicableUs
Carrington Antifungalcream20 mg/gtopicalMedline Industries, Inc.2007-01-01Not applicableUs
Clearly Confidentcream20 mg/gtopicalGaneden Biotech, Inc.2013-12-17Not applicableUs
Conazolspray20 mg/gtopicalMarcas Usa Llc2014-06-25Not applicableUs
Conazolcream20 mg/gtopicalMarcas Usa Llc2014-08-01Not applicableUs
Critic Aid Clear AFointment20 mg/gtopicalColoplast Manufacturing US, LLC2009-06-15Not applicableUs
Dermagungalcream.02 g/100gtopicalDerma Rite Industries, Llc2005-12-12Not applicableUs
Desenexpowder2 g/100gtopicalNovartis Consumer Health, Inc.2009-08-03Not applicableUs
Dg Health Miconazolecream2 g/100gvaginalDolgencorp, LLC2010-01-17Not applicableUs
Dg Health Miconazole 3kitDolgencorp Inc2010-02-22Not applicableUs
Elta Trivasecream20 g/1000gtopicalSwiss American Products2002-04-30Not applicableUs
Equaline Athletes Footspray2 g/100gtopicalSupervalu Inc2004-09-11Not applicableUs
Equaline Miconazole 1kitSupervalu Inc2010-06-11Not applicableUs
Equaline Miconazole 1kitSupervalu Inc2010-06-11Not applicableUs
Equaline Miconazole 3kitSupervalu Inc2012-01-16Not applicableUs
Equaline Miconazole 3kitSupervalu Inc2006-03-16Not applicableUs
Equaline Miconazole 7cream2 g/100gvaginalSupervalu Inc2004-11-10Not applicableUs
Equate Athletes Footspray2 g/100gtopicalWal Mart Stores Inc2011-09-18Not applicableUs
Equate Miconazole 1kitWal Mart Stores Inc2013-08-12Not applicableUs
Equate Miconazole 1kitWal Mart Stores Inc2010-06-09Not applicableUs
Exchange Select Miconazole 1kitArmy & Air Force Exchange Service2016-03-25Not applicableUs
Family Wellness Miconazole 3kitFamily Dollar Services Inc2013-03-29Not applicableUs
Femmesil Creme Maximum Strengthcream2 g/100gtopicalAidance Skincare & Topical Solutions, LLC2012-09-07Not applicableUs
Femmesil Maximum Strengthointment2 g/100gtopicalAidance Skincare & Topical Solutions, LLC2012-09-07Not applicableUs
Foot Silkapowder2 g/100mLtopicalGenomma Lab2016-02-25Not applicableUs
Fungoid Tincturetincture20 mg/mLtopicalPedinol Pharmacal, Inc.1994-01-01Not applicableUs
Fungoid Tincture Treatment KitkitPedinol Pharmacal, Inc.1994-01-01Not applicableUs
Genrx Daily Defense Antifungalpowder20 mg/gtopicalPure Tek Corporation2013-01-08Not applicableUs
Genrx Daily Defense Antifungalcream20 mg/mLtopicalPure Tek Corporation2013-01-08Not applicableUs
Good Neighbor Pharmacy Miconazole 1kitAmerisource Bergen2010-06-11Not applicableUs
Good Neighbor Pharmacy Miconazole 3kitAmerisource Bergen2012-09-04Not applicableUs
Good Neighbor Pharmacy Miconazole 7cream2 g/100gvaginalAmerisource Bergen1999-10-11Not applicableUs
Good Neighbor Pharmacy Miconazole NitratekitAmerisource Bergen2000-05-02Not applicableUs
Good Sense Miconazole 1kitL. Perrigo Company2010-06-29Not applicableUs
Good Sense Miconazole 3kitL Perrigo Company2000-02-25Not applicableUs
Good Sense Miconazole 3kitL Perrigo Company2007-04-02Not applicableUs
Good Sense Miconazole 7cream2 g/100gvaginalL Perrigo Company2000-02-22Not applicableUs
Good Sense Miconazole 7cream2 g/100gvaginalL Perrigo Company1999-07-30Not applicableUs
Green Tetterineointment2 g/100gtopicalS.S.S. Company1994-07-31Not applicableUs
Harris Teeter Miconazole 3kitHarris Teeter, LLC2015-11-21Not applicableUs
Harris Teeter Miconazole 7cream2 g/100gvaginalHarris Teeter, LLC2015-11-21Not applicableUs
Healthy Accents Miconazole 3kitDZA Brands LLC2008-04-01Not applicableUs
Healthy Accents Miconazole 7cream2 g/100gvaginalDZA Brands LLC2014-12-03Not applicableUs
Healthy Accents Miconazole 7cream2 g/100gvaginalDZA Brands LLC2008-03-03Not applicableUs
Hongo Killeraerosol, spray.2 g/10gtopicalEfficient Laboratories Inc2004-10-01Not applicableUs
Image Essentials Miconazole TreatmentkitKmart Corporation2015-02-24Not applicableUs
Image Essentials Miconazole TreatmentkitKmart Corporation2014-12-03Not applicableUs
Image Essentials Miconazole TreatmentkitKmart Corporation2015-08-20Not applicableUs
Image Essentials Miconazole TreatmentkitKmart Corporation2015-08-20Not applicableUs
Image Essentials Miconazole TreatmentkitKmart Corporation2015-02-04Not applicableUs
Kaiser Permanente Miconazole Nitratecream20 mg/gtopicalKAISER FOUNDATION HOSPITALS1991-10-01Not applicableUs
Kendall Antifungalcream2 g/100gtopicalCOVIDIEN INC.2011-04-14Not applicableUs
Lagicam Antifungalcream40 mg/gvaginalGenomma Lab Usa, Inc.2005-03-02Not applicableUs
Leader Medicatedaerosol, spray2.6 g/130gtopicalCardinal Health Inc.2010-03-15Not applicableUs
Leader Medicatedpowder1.42 g/71gtopicalCardinal Health Inc.2010-10-31Not applicableUs
Leader Miconazole 1kitCardinal Health2011-01-19Not applicableUs
Lotrimin AF Antifungalspray20 mg/gtopicalMSD Consumer Care, Inc.2013-09-30Not applicableUs
Lotrimin Antifungalaerosol, powder20 mg/gtopicalMSD Consumer Care, Inc.1993-09-01Not applicableUs
Lotrimin Antifungalaerosol, powder20 mg/gtopicalMSD Consumer Care, Inc.1993-09-01Not applicableUs
Lotrimin Antifungalpowder20 mg/gtopicalMSD Consumer Care, Inc.1993-09-01Not applicableUs
Lotrimin Antifungalaerosol, powder20 mg/gtopicalMSD Consumer Care, Inc.1993-09-01Not applicableUs
Macerrx Webcream2 g/100gtopicalClinical Therapeutic Solutions2013-06-06Not applicableUs
Makesensecream2 g/100gtopicalCherry Hill Sales Co2014-07-15Not applicableUs
Medicated Anti-fungal Miconazoleliquid2 g/100gtopicalAmerican Spraytech, Llc2010-06-02Not applicableUs
Meijer Miconazole 3cream40 mg/gvaginalMeijer Distribution Inc2005-03-02Not applicableUs
Micatincream20 mg/gtopicalWell Spring Pharmaceutical Corporation2009-06-24Not applicableUs
Micatin Cream - 2%cream2 %topicalWellspring Pharmaceutical Canada Corp1974-12-31Not applicableCanada
Micatin Powder Spray - Unscented 2%aerosol2 %topicalWellspring Pharmaceutical Canada Corp1997-06-16Not applicableCanada
Miconazolecream20 mg/gtopicalGalentic Pharma (India) Priva Te Limited2013-07-18Not applicableUs
Miconazolecream20 mg/gtopicalKinray, Inc.2013-03-21Not applicableUs
Miconazolecream2 g/100gtopicalChain Drug Consortium, LLC2009-05-15Not applicableUs
Miconazole 1kitMeijer Distribution Inc2010-06-09Not applicableUs
Miconazole 1kitWestern Family Foods Inc2011-07-11Not applicableUs
Miconazole 1kitCVS Pharmacy2010-06-08Not applicableUs
Miconazole 1kitRite Aid Corporation2010-06-16Not applicableUs
Miconazole 1kitSafeway2010-08-30Not applicableUs
Miconazole 1kitMeijer Distribution Inc2010-06-11Not applicableUs
Miconazole 1kitRite Aid Corporation2010-06-09Not applicableUs
Miconazole 1kitH E B2010-06-07Not applicableUs
Miconazole 1kitWalgreen Company2010-06-10Not applicableUs
Miconazole 1kitH E B2010-06-07Not applicableUs
Miconazole 1kitHy Vee Inc2010-06-13Not applicableUs
Miconazole 1kitKroger Company2013-07-23Not applicableUs
Miconazole 1kitMeijer Distribution Inc2010-06-09Not applicableUs
Miconazole 1kitHy Vee Inc2010-06-13Not applicableUs
Miconazole 1kitWalgreen Company2011-12-15Not applicableUs
Miconazole 1kitWalgreen Company2010-06-08Not applicableUs
Miconazole 1kitKroger Company2010-06-08Not applicableUs
Miconazole 1 Feminine CarekitRite Aid Corporation2010-06-09Not applicableUs
Miconazole 1 Yeast Infection ReliefkitCVS Pharmacy2010-06-08Not applicableUs
Miconazole 3kitHy Vee Inc2009-07-01Not applicableUs
Miconazole 3kitWalgreen Company2004-07-19Not applicableUs
Miconazole 3kitRite Aid Corporation2006-08-18Not applicableUs
Miconazole 3kitWalgreen Company2005-07-08Not applicableUs
Miconazole 3kitKroger Company2000-02-23Not applicableUs
Miconazole 3kitRite Aid Corporation2014-02-12Not applicableUs
Miconazole 3kitMeijer Distribution Inc2000-02-04Not applicableUs
Miconazole 3kitKroger Company2004-08-17Not applicableUs
Miconazole 3kitH E B2006-03-14Not applicableUs
Miconazole 3cream40 mg/gvaginalShopko Stores Operating Co., LLC2005-03-02Not applicableUs
Miconazole 3kitWalgreen Company2006-09-06Not applicableUs
Miconazole 3kitWalgreen Company2005-07-01Not applicableUs
Miconazole 3kitWestern Family Foods Inc2005-01-21Not applicableUs
Miconazole 3kitCVS Pharmacy2014-02-28Not applicableUs
Miconazole 3 Combination PackkitRite Aid2001-03-01Not applicableUs
Miconazole 3 Combination PackkitvaginalCardinal Health2001-02-02Not applicableUs
Miconazole 3 Combination PackkitvaginalCardinal Health2002-12-02Not applicableUs
Miconazole 3 Combination PackkitWakefern Food Corporation2007-05-29Not applicableUs
Miconazole 3 Combination PackkitWal Mart Stores, Inc.2007-06-11Not applicableUs
Miconazole 3 Combination PackkitChain Drug Consortium, LLC2003-09-11Not applicableUs
Miconazole 3 Combination PackkitFred's Inc.2009-06-09Not applicableUs
Miconazole 3 Combination PackkitvaginalMajor Pharmaceuticals2002-12-02Not applicableUs
Miconazole 3 Combination PackkitCVS Pharmacy2001-03-01Not applicableUs
Miconazole 3 DaykitPublix Super Markets Inc2009-06-26Not applicableUs
Miconazole 3 Day Ovule Treatment 400mgsuppository400 mgvaginalVita Health Products Inc1996-12-31Not applicableCanada
Miconazole 7cream2 g/100gvaginalWalgreen Company2000-12-01Not applicableUs
Miconazole 7cream2 g/100gvaginalChain Drug Consortium, LLC2003-09-11Not applicableUs
Miconazole 7cream2 g/100gvaginalCVS2009-09-15Not applicableUs
Miconazole 7cream2 g/100gvaginalWestern Family Foods Inc1999-10-08Not applicableUs
Miconazole 7cream20 mg/gvaginalPreferred Pharmaceuticals, Inc.2012-07-27Not applicableUs
Miconazole 7cream2 g/100gvaginalSafeway1999-09-08Not applicableUs
Miconazole 7cream2 g/100gvaginalKroger Company1999-04-28Not applicableUs
Miconazole 7cream2 g/100gvaginalCardinal Health (Leader)2014-05-31Not applicableUs
Miconazole 7cream2 g/100gvaginalExchange Select2002-07-12Not applicableUs
Miconazole 7cream2 g/100gvaginalWal Mart Stores, Inc.2008-03-03Not applicableUs
Miconazole 7cream2 g/100gvaginalH E B2006-01-09Not applicableUs
Miconazole 7cream2 g/100gvaginalChain Drug Marketing Association Inc.2010-07-01Not applicableUs
Miconazole 7cream2 g/100gvaginalRexall2010-07-01Not applicableUs
Miconazole 7cream2 g/100gvaginalRite Aid2001-03-01Not applicableUs
Miconazole 7cream2 g/100gvaginalActavis Pharma, Inc.2011-09-16Not applicableUs
Miconazole 7suppository100 mg/1vaginalActavis Pharma, Inc.1993-11-19Not applicableUs
Miconazole 7cream2 g/100gvaginalKroger Company2002-07-15Not applicableUs
Miconazole 7cream2 mg/100gvaginalShopko Stores Operating Co., LLC1997-01-13Not applicableUs
Miconazole 7cream2 g/100gvaginalMajor Pharmaceuticals2009-04-21Not applicableUs
Miconazole 7cream2 g/100gvaginalFred's Inc.2009-06-09Not applicableUs
Miconazole 7cream2 g/100gvaginalCVS Pharmacy1999-09-02Not applicableUs
Miconazole 7suppository100 mg/1vaginalMc Kesson2011-12-09Not applicableUs
Miconazole 7cream2 g/100gvaginalMeijer Distribution Inc2000-02-04Not applicableUs
Miconazole 7cream2 g/100gvaginalHy Vee Inc2000-02-15Not applicableUs
Miconazole 7cream2 g/100gvaginalFamily Dollar Services Inc.2006-06-06Not applicableUs
Miconazole 7cream2 g/100gvaginalWestern Family Foods Inc2011-08-10Not applicableUs
Miconazole 7 - Crm Vag 2%cream2 %vaginalTechnilab Pharma Inc.1996-11-042005-08-05Canada
Miconazole Nitratecream20 mg/gtopicalRebel Distributors Corp2003-09-01Not applicableUs
Miconazole Nitratecream20 mg/gtopicalPreferred Pharmaceuticals, Inc.2014-09-02Not applicableUs
Miconazole Nitratepowder1.42 g/71gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Miconazole Nitrateaerosol, spray3 g/150gtopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole Nitratepowder1.42 g/71gtopicalAmerisource Bergen Drug Corporation2012-01-10Not applicableUs
Miconazole Nitrateaerosol, spray3 g/150gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Miconazole Nitratecream20 mg/gvaginalG&W Laboratories, Inc.1996-02-22Not applicableUs
Miconazole Nitratepowder1.42 g/71gtopicalCVS Pharmacy2012-01-04Not applicableUs
Miconazole Nitratepowder1.42 g/71gtopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole Nitratesuppository100 ug/1vaginalRebel Distributors Corp1997-04-30Not applicableUs
Miconazole Nitrateaerosol, spray1.3 g/131gtopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole Nitratesuppository100 ug/1vaginalG&W Laboratories, Inc.1997-04-30Not applicableUs
Miconazole Nitrateaerosol, spray2.6 g/130gtopicalTopco Associates LLC2012-01-03Not applicableUs
Miconazole Nitratecream20 mg/gtopicalQualitest Pharmaceuticals2003-09-01Not applicableUs
Miconazole Nitrateaerosol, spray3 g/150gtopicalHarmon Store Inc.2012-01-17Not applicableUs
Miconazole Nitratecream20 mg/gtopicalPhysicians Total Care, Inc.2012-03-20Not applicableUs
Miconazole Nitratepowder1.42 g/71gtopicalHarmon Store Inc.2014-01-27Not applicableUs
Miconazole Nitrateaerosol, powder2.6 g/130gtopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole Nitratecream20 mg/gvaginalRebel Distributors Corp2008-01-01Not applicableUs
Miconazole Nitrateaerosol, powder2.6 g/130gtopicalWal Mart Stores, Inc.2014-02-25Not applicableUs
Miconazole Nitratecream40 mg/gvaginalTaro Pharmaceuticals U.S.A., Inc.2005-03-02Not applicableUs
Miconazole Nitratepowder1.42 g/71gtopicalChain Drug Consortium, LLC2011-06-10Not applicableUs
Miconazole Nitratecream20 mg/gvaginalPreferred Pharmaceuticals Inc.2016-02-01Not applicableUs
Miconazole Nitratecream20 mg/gvaginalTaro Pharmaceuticals U.S.A., Inc.1997-01-13Not applicableUs
Miconazole Nitrateaerosol, spray3 g/150gtopicalChain Drug Consortium, LLC2010-01-05Not applicableUs
Miconazole Nitrateaerosol, powder2.6 g/130gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Miconazole Nitratecream20 mg/gvaginalCentral Texas Community Health Centers1996-02-22Not applicableUs
Miconazole Nitratepowder1.42 g/71gtopicalTopco Associates LLC2014-10-31Not applicableUs
Miconazole Nitratecream20 mg/gtopicalTaro Pharmaceuticals U.S.A., Inc.1991-10-01Not applicableUs
Miconazole Nitratepowder1.42 g/71gtopicalCVS Pharmacy2014-01-01Not applicableUs
Miconazole Nitrateaerosol, powder2.6 g/130gtopicalPremier Brands of America Inc.2013-01-01Not applicableUs
Miconazole Nitratespray3 g/150gtopicalWalgreens Company2010-05-18Not applicableUs
Miconazole Nitrate 2% Cream Antifungalcream2 g/100gtopicalTrifecta Pharmaceuticals Usa Llc2016-03-22Not applicableUs
Miconazole Nitrate Vaginal Cream 2%cream2 %vaginalVita Health Products Inc2003-03-13Not applicableCanada
Miconazole Nitrate Vaginal Cream USP, 2%cream2 %vaginalTaro Pharmaceuticals Inc1997-08-12Not applicableCanada
Miconolecream20 mg/gtopicalOption Labs2013-10-15Not applicableUs
Micozolecream2 %vaginalTaro Pharmaceuticals Inc1997-08-11Not applicableCanada
Micro-guard (af)powder20 mg/gtopicalColoplast Manufacturing US, LLC2009-06-15Not applicableUs
Molecular AF Molecular Creamcream.3 g/14gtopicalRenu Laboratories, Inc.2015-03-31Not applicableUs
Monazole 7 - Crm 20mg/gcream20 mgvaginalTechnilab Pharma Inc.1997-01-212001-09-05Canada
Monistat 1 Combination PackkitInsight Pharmaceuticals2001-06-29Not applicableUs
Monistat 1 Combination PackkitInsight Pharmaceuticals2001-06-29Not applicableUs
Monistat 1 Combination Pack Triple ActionkitInsight Pharmaceuticals2001-06-29Not applicableUs
Monistat 1 Vaginal Ovulesuppository1200 mgvaginalInsight Pharmaceuticals LLC1999-02-26Not applicableCanada
Monistat 3 3-day Pre-filled Applicatorscream40 mg/gvaginalInsight Pharmaceuticals1998-03-30Not applicableUs
Monistat 3 Combination PackkitInsight Pharmaceuticals2009-12-10Not applicableUs
Monistat 3 Combination PackkitInsight Pharmaceuticals1996-04-16Not applicableUs
Monistat 3 Combination PackkitMc Neil Ppc, Inc.2009-12-10Not applicableUs
Monistat 3 Combination PackkitPhysicians Total Care, Inc.2012-03-27Not applicableUs
Monistat 3 Combination PackkitMc Neil Ppc, Inc.2009-12-10Not applicableUs
Monistat 3 Combination Pack 3 Ovule InsertskitInsight Pharmaceuticals1996-04-16Not applicableUs
Monistat 3 Combination Pack Triple ActionkitInsight Pharmaceuticals1996-04-16Not applicableUs
Monistat 3 Vaginal Creamcream4 %vaginalInsight Pharmaceuticals LLC2001-10-10Not applicableCanada
Monistat 3 Vaginal Ovulesovule400 mgvaginalInsight Pharmaceuticals LLC1981-12-31Not applicableCanada
Monistat 7 7-day Disposable Applicatorscream20 mg/gvaginalInsight Pharmaceuticals2010-04-15Not applicableUs
Monistat 7 Combination Pack 7-day Pre-filled ApplicatorskitInsight Pharmaceuticals1993-04-26Not applicableUs
Monistat 7 Combination Pack 7-day Pre-filled ApplicatorskitMc Neil Ppc, Inc.2011-10-15Not applicableUs
Monistat 7 Combination Pack Triple ActionkitMc Neil, Ppc, Inc.2010-04-10Not applicableUs
Monistat 7 Combination Pack Triple ActionkitInsight Pharmaceuticals1993-04-26Not applicableUs
Monistat 7 Sup Vag 100mgsuppository100 mgvaginalMcneil Consumer Healthcare Division Of Johnson & Johnson Inc1978-12-312005-07-22Canada
Monistat 7 Vaginal Creamcream2 %vaginalInsight Pharmaceuticals LLC1978-12-31Not applicableCanada
Monistat 7 With Reusable Applicatorcream20 mg/gvaginalInsight Pharmaceuticals1993-04-26Not applicableUs
Monistat Derm Creamcream2 %topicalInsight Pharmaceuticals LLC1980-12-31Not applicableCanada
Nail Mdcream200 mg/mgtopicalOmg Medical Group, Llc2013-02-14Not applicableUs
Novana Antifungal Barrier With Miconazolecream.02 mL/mLtopicalNovana Medical, Llc2012-04-04Not applicableUs
Premier Value Miconazole 3cream40 mg/gvaginalChain Drug Consortium2005-03-02Not applicableUs
Previsense Antifungal Moisture Barrier With Protease Technologycream2 g/100gtopicalMolnlycke Health Care2016-04-01Not applicableUs
Quality Choice 3 Day Vaginalcream40 mg/gvaginalChain Drug Marketing Association2005-03-02Not applicableUs
Remedy Antifungalpowder2 g/100gtopicalMedline Industries, Inc.2012-11-19Not applicableUs
Remedy Antifungalpowder2 g/100gtopicalMedline Industries, Inc.2012-11-19Not applicableUs
Remedy Antifungal Targeted Treatmentpowder20 mg/gtopicalMedline Industries, Inc.2007-01-01Not applicableUs
Remedy Antifungal With Olivaminecream2 g/100gtopicalMedline Industries, Inc.2007-01-01Not applicableUs
Remedy With Phytoplex Antifungal Clearointment2 g/100gtopicalMedline Industries Inc.2011-08-01Not applicableUs
Rexall Miconazole 3kitDolgencorp Inc2010-12-14Not applicableUs
Secura Antifungal Extra Thickcream20 mg/gtopicalSmith & Nephew Medical Ltd2003-08-01Not applicableUs
Secura Antifungal Extra Thickcream20 mg/gtopicalSmith & Nephew, Inc.2003-08-012018-06-30Us
Secura Antifungal Greaselesscream20 mg/gtopicalSmith & Nephew Medical Ltd2003-08-01Not applicableUs
Secura Antifungal Greaselesscream20 mg/gtopicalSmith & Nephew, Inc.2003-08-012018-06-30Us
Selan Antifungalcream2 g/100gtopicalPj Noyes Co. Inc.2003-11-05Not applicableUs
Signature Care Athletes Footspray2 g/100gtopicalSafeway2015-10-09Not applicableUs
Signature Care Miconazole 1kitSafeway2015-09-28Not applicableUs
Signature Care Miconazole 3kitSafeway2015-10-06Not applicableUs
Signature Care Miconazole 3kitSafeway2015-12-09Not applicableUs
Signature Care Miconazole 7cream2 g/100gvaginalSafeway2015-11-03Not applicableUs
Smart Sense 3 Day TreatmentkitKmart Corporation2011-05-25Not applicableUs
Smart Sense 3 Day Treatment Vaginal AntifungalkitKmart Corporation2011-05-16Not applicableUs
Smart Sense 7 Day Treatmentcream2 g/100gvaginalKmart Corporation2011-02-10Not applicableUs
Smart Sense Miconazole 1kitKmart Corporation2010-06-16Not applicableUs
Smart Sense Miconazole 1kitKmart Corporation2010-06-15Not applicableUs
Smart Sense Miconazole 1kitKmart Corporation2010-06-15Not applicableUs
Soothe and Cool Treatcream20 mg/100gtopicalMedline Industries, Inc.2007-01-01Not applicableUs
Sunmark Antifungalcream20 mg/gtopicalMc Kesson1991-10-01Not applicableUs
Sunmark Miconazole 3kitMc Kesson2004-07-20Not applicableUs
Sunmark Miconazole 3kitMc Kesson2003-09-05Not applicableUs
Sunmark Miconazole 3kitMc Kesson2003-09-05Not applicableUs
Sunmark Miconazole 7cream2 g/100gvaginalMc Kesson2003-07-31Not applicableUs
Sunmark Miconazole 7cream2 g/100gvaginalMc Kesson2003-11-25Not applicableUs
Terrasil Rapid-relief VaginalkitAidance Skincare & Topical Solutions, LLC2014-04-18Not applicableUs
Thera Antifungal Bodypowder20 mg/gtopicalMc Kesson Medical Surgical Inc.2011-09-01Not applicableUs
Tineacide Antifungalcream.7 g/35gtopicalBlaine Labs Inc.2013-06-01Not applicableUs
Ting Spray Powderaerosol, powder2.56 g/128gtopicalInsight Pharmaceuticals2009-07-16Not applicableUs
Topcare Miconazole 1kitTopco Associates LLC2010-06-15Not applicableUs
Topcare Miconazole 1kitTopco Associates LLC2010-06-17Not applicableUs
Topcare Miconazole 3 Combination PackkitTopco Associates LLC2000-05-10Not applicableUs
Topcare Miconazole 3 Combination PackkitTopco Associates LLC2004-11-17Not applicableUs
Topcare Miconazole 3 Yeast Infection Reliefcream40 mg/gvaginalTopco Associates LLC2005-03-02Not applicableUs
Topcare Miconazole 7cream2 g/100gvaginalTopco Associates LLC2000-02-29Not applicableUs
Touchless Care Antifungalspray2 g/100gtopicalCrawford Healthcare, Inc.2014-12-29Not applicableUs
Triple Paste-AFointment2 g/100gtopicalSummers Laboratories Inc2013-10-30Not applicableUs
Up and Up Jock Itch Reliefspray2 g/100gtopicalTarget Corporation2013-09-25Not applicableUs
Up and Up MiconazolekitTarget Corporation2010-07-08Not applicableUs
Up and Up Miconazole 1kitTarget Corporation2010-09-03Not applicableUs
Up and Up Miconazole 3kitTarget Corporation2009-08-12Not applicableUs
Up and Up Miconazole 3kitTarget Corporation2009-08-17Not applicableUs
Up and Up Miconazole 7cream2 g/100gvaginalTarget Corporation2009-08-26Not applicableUs
Vagistat-3kitNovartis Consumer Health, Inc.2000-02-25Not applicableUs
Vite20liquid.3 mg/15mLtopicalBlaine Labs Inc.2016-04-01Not applicableUs
Welmedix Homecare Pro 2-IN-1 Antifungal and Skin Protectantointment2 g/100gtopicalThe Akshay Wellness Group, Inc.2013-04-01Not applicableUs
White Tetterineointment2 g/100gtopicalS.S.S. Company1995-02-28Not applicableUs
Zeasorbpowder20.6 mg/gtopicalStiefel Laboratories Inc2011-03-14Not applicableUs
Zeasorbpowder20.6 mg/gtopicalStiefel Laboratories Inc2011-03-14Not applicableUs
Zeasorb AFpowder20.6 mg/gtopicalPhysicians Total Care, Inc.2008-03-31Not applicableUs
Unapproved/Other Products Not Available
International Brands
NameCompany
DaktarinNot Available
DecocortNot Available
Femizol-MNot Available
Gyno-DaktarinNot Available
MiconazexNot Available
MonistatNot Available
Monistat-DermNot Available
Zeasorb-AFNot Available
ZimycanNot Available
Brand mixtures
NameLabellerIngredients
DermasanaOmg Medical Group, Llc
Monicure ComboInsight Pharmaceuticals LLC
Monistat 1 Combination PackInsight Pharmaceuticals LLC
Monistat 3 Dual-pakInsight Pharmaceuticals LLC
Monistat 7 Dual-pakInsight Pharmaceuticals LLC
Rash Relief AntifungalTouchless Care Concepts LLC
VusionPrestium Pharma, Inc.
Salts
Name/CASStructureProperties
Miconazole nitrate
ThumbNot applicableDBSALT001242
Categories
UNII7NNO0D7S5M
CAS number22916-47-8
WeightAverage: 416.129
Monoisotopic: 413.986023908
Chemical FormulaC18H14Cl4N2O
InChI KeyInChIKey=BYBLEWFAAKGYCD-UHFFFAOYSA-N
InChI
InChI=1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2
IUPAC Name
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
SMILES
ClC1=CC(Cl)=C(COC(CN2C=CN=C2)C2=C(Cl)C=C(Cl)C=C2)C=C1
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzylethers
Direct ParentBenzylethers
Alternative Parents
Substituents
  • Benzylether
  • 1,3-dichlorobenzene
  • Halobenzene
  • Chlorobenzene
  • N-substituted imidazole
  • Aryl halide
  • Aryl chloride
  • Heteroaromatic compound
  • Imidazole
  • Azole
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Dialkyl ether
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.
PharmacodynamicsMiconazole is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Miconazole was approved by the FDA in 1974. Miconazole prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Mechanism of actionMiconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityOral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.
Affected organisms
  • Fungi, yeast and protozoans
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9735
Blood Brain Barrier+0.9823
Caco-2 permeable+0.6096
P-glycoprotein substrateNon-substrate0.545
P-glycoprotein inhibitor INon-inhibitor0.7958
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterInhibitor0.6806
CYP450 2C9 substrateNon-substrate0.8407
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.7017
CYP450 1A2 substrateInhibitor0.9472
CYP450 2C9 inhibitorInhibitor0.939
CYP450 2D6 inhibitorInhibitor0.9413
CYP450 2C19 inhibitorInhibitor0.9591
CYP450 3A4 inhibitorInhibitor0.8861
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.9961
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.853
BiodegradationNot ready biodegradable0.9933
Rat acute toxicity2.8478 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5
hERG inhibition (predictor II)Inhibitor0.8505
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Creamtopical2 g/1000g
Powdertopical2 g/100mL
Spraytopical2 g/100g
Creamtopical.02 g/g
Ointmenttopical20 mg/g
Creamtopical.02 g/100g
Creamtopical
Powdertopical2 g/100g
Creamtopical20 g/1000g
Kit
Tincturetopical20 mg/mL
Creamtopical20 mg/mL
Creamvaginal2 g/100g
Aerosol, spraytopical.2 g/10g
Creamtopical20 mg/g
Powdertopical1.42 g/71g
Spraytopical20 mg/g
Aerosol, powdertopical20 mg/g
Powdertopical20 mg/g
Liquidtopical2 g/100g
Creamtopical2 %
Aerosoltopical2 %
Kitvaginal
Suppositoryvaginal400 mg
Creamvaginal2 mg/100g
Suppositoryvaginal100 mg/1
Aerosol, powdertopical2.6 g/130g
Aerosol, spraytopical1.3 g/131g
Aerosol, spraytopical2.6 g/130g
Aerosol, spraytopical3 g/150g
Creamvaginal20 mg/g
Spraytopical3 g/150g
Suppositoryvaginal100 ug/1
Suppositoryvaginal200 mg/1
Creamtopical.3 g/14g
Creamvaginal20 mg
Kit; capsule; creamoral; topical
Suppositoryvaginal1200 mg
Ovule; creamtopical; vaginal
Creamvaginal4 %
Ovulevaginal400 mg
Suppository; creamtopical; vaginal
Suppositoryvaginal100 mg
Creamvaginal2 %
Creamtopical200 mg/mg
Creamtopical.02 mL/mL
Tabletbuccal50 mg/1
Liquidtopical
Creamtopical2 g/100g
Creamtopical20 mg/100g
Creamtopical.7 g/35g
Aerosol, powdertopical2.56 g/128g
Creamvaginal40 mg/g
Ointmenttopical2 g/100g
Kit
Liquidtopical.3 mg/15mL
Ointmenttopical
Powdertopical20.6 mg/g
Prices
Unit descriptionCostUnit
Vusion 0.25-15-81.35% Ointment 50 gm Tube284.34USD tube
Miconazole 3 3 200 mg Suppository Box51.2USD box
Monistat-Derm 2% Cream 28.35 gm Tube41.99USD tube
Monistat-Derm 2% Cream 15 gm Tube32.0USD tube
Monistat 1 combination pack16.81USD each
Monistat 7 combination pack15.96USD each
Miconazole Nitrate 2% Cream 28 gm Tube12.99USD tube
Miconazole powder4.59USD g
Monistat 1 6.5% ointment3.6USD g
Miconazole nitrate powder3.55USD g
Vusion ointment3.17USD g
Monistat-derm 2% cream1.11USD g
Miconazole nitrate 2% cream0.19USD g
CVS Pharmacy miconazole 7 cream0.18USD g
Miconazole 7 cream0.15USD g
Antifungal 2% cream0.1USD g
Micatin 2% aerosol spray0.05USD g
Lotrimin af 2% liquid spray0.04USD g
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5514698 No1994-03-212014-03-21Us
US6153635 No2000-11-282020-11-28Us
US6916485 No2002-09-112022-09-11Us
US7651698 No2002-09-112022-09-11Us
US8147852 No2008-03-302028-03-30Us
US8518442 No2002-09-112022-09-11Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point159-163 °CNot Available
water solubility1g/100mL (20 °C)Not Available
logP6.1Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.000763 mg/mLALOGPS
logP5.86ALOGPS
logP5.96ChemAxon
logS-5.7ALOGPS
pKa (Strongest Basic)6.77ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area27.05 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity103.07 m3·mol-1ChemAxon
Polarizability39.54 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
MSMass Spectrum (Electron Ionization)splash10-0bt9-4900000000-3f143064c2acde7e15a4View in MoNA
References
Synthesis Reference

DrugSyn.org

US3717655
General ReferencesNot Available
External Links
ATC CodesA01AB09A07AC01D01AC02D01AC52G01AF04J02AB01S02AA13
AHFS Codes
  • 84:04.08.08
PDB EntriesNot Available
FDA labelDownload (650 KB)
MSDSDownload (73.7 KB)
Interactions
Drug Interactions
Drug
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Miconazole.
ChlorpropamideMiconazole may increase the hypoglycemic activities of Chlorpropamide.
FosphenytoinThe serum concentration of Fosphenytoin can be increased when it is combined with Miconazole.
GliclazideMiconazole may increase the hypoglycemic activities of Gliclazide.
GlimepirideMiconazole may increase the hypoglycemic activities of Glimepiride.
GlipizideMiconazole may increase the hypoglycemic activities of Glipizide.
GlyburideMiconazole may increase the hypoglycemic activities of Glyburide.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Miconazole.
TolazamideMiconazole may increase the hypoglycemic activities of Tolazamide.
TolbutamideMiconazole may increase the hypoglycemic activities of Tolbutamide.
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Miconazole.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Yeast
Pharmacological action
yes
Actions
inhibitor
General Function:
Sterol 14-demethylase activity
Specific Function:
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
Gene Name:
ERG11
Uniprot ID:
P10613
Molecular Weight:
60674.965 Da
References
  1. White TC, Marr KA, Bowden RA: Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin Microbiol Rev. 1998 Apr;11(2):382-402. [PubMed:9564569 ]
  2. Ghannoum MA, Rice LB: Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. Clin Microbiol Rev. 1999 Oct;12(4):501-17. [PubMed:10515900 ]
  3. Edlind T, Smith L, Henry K, Katiyar S, Nickels J: Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling. Mol Microbiol. 2002 Oct;46(1):257-68. [PubMed:12366848 ]
  4. Georgopapadakou NH, Walsh TJ: Antifungal agents: chemotherapeutic targets and immunologic strategies. Antimicrob Agents Chemother. 1996 Feb;40(2):279-91. [PubMed:8834867 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Tetrahydrobiopterin binding
Specific Function:
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by ...
Gene Name:
NOS3
Uniprot ID:
P29474
Molecular Weight:
133287.62 Da
References
  1. Wolff DJ, Datto GA, Samatovicz RA: The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents. J Biol Chem. 1993 May 5;268(13):9430-6. [PubMed:7683652 ]
  2. Bogle RG, Whitley GS, Soo SC, Johnstone AP, Vallance P: Effect of anti-fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase. Br J Pharmacol. 1994 Apr;111(4):1257-61. [PubMed:7518297 ]
  3. Sennequier N, Wolan D, Stuehr DJ: Antifungal imidazoles block assembly of inducible NO synthase into an active dimer. J Biol Chem. 1999 Jan 8;274(2):930-8. [PubMed:9873034 ]
  4. Dudek RR, Conforto A, Pinto V, Wildhirt S, Suzuki H: Inhibition of endothelial nitric oxide synthase by cytochrome P-450 reductase inhibitors. Proc Soc Exp Biol Med. 1995 May;209(1):60-4. [PubMed:7536941 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Tetrahydrobiopterin binding
Specific Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-n...
Gene Name:
NOS2
Uniprot ID:
P35228
Molecular Weight:
131116.3 Da
References
  1. Wolff DJ, Datto GA, Samatovicz RA: The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents. J Biol Chem. 1993 May 5;268(13):9430-6. [PubMed:7683652 ]
  2. Bogle RG, Whitley GS, Soo SC, Johnstone AP, Vallance P: Effect of anti-fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase. Br J Pharmacol. 1994 Apr;111(4):1257-61. [PubMed:7518297 ]
  3. Sennequier N, Wolan D, Stuehr DJ: Antifungal imidazoles block assembly of inducible NO synthase into an active dimer. J Biol Chem. 1999 Jan 8;274(2):930-8. [PubMed:9873034 ]
  4. Dudek RR, Conforto A, Pinto V, Wildhirt S, Suzuki H: Inhibition of endothelial nitric oxide synthase by cytochrome P-450 reductase inhibitors. Proc Soc Exp Biol Med. 1995 May;209(1):60-4. [PubMed:7536941 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity
Specific Function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key ...
Gene Name:
KCNMA1
Uniprot ID:
Q12791
Molecular Weight:
137558.115 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium channel regulator activity
Specific Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivati...
Gene Name:
KCNMB1
Uniprot ID:
Q16558
Molecular Weight:
21797.27 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium channel regulator activity
Specific Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 n...
Gene Name:
KCNMB2
Uniprot ID:
Q9Y691
Molecular Weight:
27129.37 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium channel regulator activity
Specific Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inac...
Gene Name:
KCNMB3
Uniprot ID:
Q9NPA1
Molecular Weight:
31603.26 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium channel regulator activity
Specific Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel o...
Gene Name:
KCNMB4
Uniprot ID:
Q86W47
Molecular Weight:
23948.465 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Protein phosphatase binding
Specific Function:
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMe...
Gene Name:
KCNN4
Uniprot ID:
O15554
Molecular Weight:
47695.12 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Small conductance calcium-activated potassium channel activity
Specific Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).
Gene Name:
KCNN1
Uniprot ID:
Q92952
Molecular Weight:
59986.87 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Small conductance calcium-activated potassium channel activity
Specific Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Gene Name:
KCNN2
Uniprot ID:
Q9H2S1
Molecular Weight:
63759.03 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Small conductance calcium-activated potassium channel activity
Specific Function:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Gene Name:
KCNN3
Uniprot ID:
Q9UGI6
Molecular Weight:
82025.305 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Alvarez J, Montero M, Garcia-Sancho J: High affinity inhibition of Ca(2+)-dependent K+ channels by cytochrome P-450 inhibitors. J Biol Chem. 1992 Jun 15;267(17):11789-93. [PubMed:1376313 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Specific Function:
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are r...
Gene Name:
KCNH2
Uniprot ID:
Q12809
Molecular Weight:
126653.52 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Kikuchi K, Nagatomo T, Abe H, Kawakami K, Duff HJ, Makielski JC, January CT, Nakashima Y: Blockade of HERG cardiac K+ current by antifungal drug miconazole. Br J Pharmacol. 2005 Mar;144(6):840-8. [PubMed:15778703 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity
Specific Function:
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.
Gene Name:
KCNH6
Uniprot ID:
Q9H252
Molecular Weight:
109923.705 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Kikuchi K, Nagatomo T, Abe H, Kawakami K, Duff HJ, Makielski JC, January CT, Nakashima Y: Blockade of HERG cardiac K+ current by antifungal drug miconazole. Br J Pharmacol. 2005 Mar;144(6):840-8. [PubMed:15778703 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity
Specific Function:
Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Gene Name:
KCNH7
Uniprot ID:
Q9NS40
Molecular Weight:
134998.525 Da
References
  1. Hatton CJ, Peers C: Effects of cytochrome P-450 inhibitors on ionic currents in isolated rat type I carotid body cells. Am J Physiol. 1996 Jul;271(1 Pt 1):C85-92. [PubMed:8760033 ]
  2. Kikuchi K, Nagatomo T, Abe H, Kawakami K, Duff HJ, Makielski JC, January CT, Nakashima Y: Blockade of HERG cardiac K+ current by antifungal drug miconazole. Br J Pharmacol. 2005 Mar;144(6):840-8. [PubMed:15778703 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. [PubMed:15969931 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid 11-beta-monooxygenase activity
Specific Function:
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Gene Name:
CYP11B1
Uniprot ID:
P15538
Molecular Weight:
57572.44 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular Weight:
57882.48 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Gene Name:
CYP2A6
Uniprot ID:
P11509
Molecular Weight:
56501.005 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. [PubMed:11961113 ]
  2. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  3. Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. [PubMed:12235267 ]
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Drug created on June 13, 2005 07:24 / Updated on June 30, 2016 01:51