Voltage-gated potassium channel subunit beta-1
Details
- Name
- Voltage-gated potassium channel subunit beta-1
- Synonyms
- 1.1.1.-
- K(+) channel subunit beta-1
- KCNA1B
- Kv-beta-1
- Gene Name
- KCNAB1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052265|Voltage-gated potassium channel subunit beta-1 MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQL ALLREVEMNWYLKLCDLSSEHTTVCTTGMPHRNLGKSGLRVSCLGLGTWVTFGGQISDEV AERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETE RGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTS RWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLAC GIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAV AWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS
- Number of residues
- 419
- Molecular Weight
- 46563.13
- Theoretical pI
- Not Available
- GO Classification
- Functionsaldo-keto reductase (NADP) activity / ion channel binding / NADPH binding / potassium channel regulator activity / protein domain specific binding / voltage-gated potassium channel activityProcessesbrain development / diaphragm development / heart development / learning or memory / myoblast differentiation / negative regulation of delayed rectifier potassium channel activity / negative regulation of voltage-gated potassium channel activity / oxidation-reduction process / potassium ion transport / regulation of delayed rectifier potassium channel activity / regulation of potassium ion transmembrane transport / skeletal muscle tissue developmentComponentscytosol / dendrite cytoplasm / extrinsic component of cytoplasmic side of plasma membrane / juxtaparanode region of axon / perikaryon / plasma membrane / potassium channel complex / proximal dendrite / voltage-gated potassium channel complex
- General Function
- Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).
- Specific Function
- Aldo-keto reductase (nadp) activity
- Pfam Domain Function
- Aldo_ket_red (PF00248)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052266|Voltage-gated potassium channel subunit beta-1 (KCNAB1) ATGCTGGCAGCCCGGACAGGGGCAGCGGGGAGTCAGATCTCAGAGGAGAACACCAAGTTA AGGAGACAGTCTGGGTTTTCTGTAGCAGGGAAAGACAAATCTCCCAAGAAAGCCTCAGAA AACGCTAAAGACAGCAGCCTTAGTCCCTCAGGGGAAAGCCAGCTCAGGGCGCGTCAACTG GCTCTGCTGCGCGAAGTGGAGATGAACTGGTACCTAAAGCTCTGCGACCTGTCCAGCGAG CACACCACCGTCTGCACCACAGGCATGCCGCACAGGAATCTTGGAAAATCAGGACTCAGA GTTTCTTGCTTGGGTCTTGGAACATGGGTGACATTTGGAGGTCAAATTTCAGATGAGGTT GCTGAACGGCTGATGACCATCGCCTATGAAAGTGGTGTTAACCTCTTTGATACTGCCGAA GTCTATGCTGCTGGAAAGGCTGAAGTGATTCTGGGGAGCATCATCAAGAAGAAAGGCTGG AGGAGGTCCAGTCTGGTCATAACAACCAAACTCTACTGGGGTGGAAAAGCTGAAACAGAA AGAGGGCTGTCAAGAAAGCATATTATTGAAGGATTGAAGGGCTCCCTCCAGAGGCTGCAG CTCGAGTATGTGGATGTGGTCTTTGCAAATCGACCGGACAGTAACACTCCCATGGAAGAA ATTGTCCGAGCCATGACACATGTGATAAACCAAGGCATGGCGATGTACTGGGGCACCTCG AGATGGAGTGCTATGGAGATCATGGAAGCCTATTCTGTAGCAAGACAGTTCAATATGATC CCACCGGTCTGTGAACAAGCTGAGTACCATCTTTTCCAGAGAGAGAAAGTGGAGGTCCAG CTGCCAGAGCTCTACCACAAAATAGGTGTTGGCGCAATGACATGGTCTCCACTTGCCTGT GGAATCATCTCAGGAAAATACGGAAACGGGGTGCCTGAAAGTTCCAGGGCTTCACTGAAG TGCTACCAGTGGTTGAAAGAAAGAATTGTAAGTGAAGAAGGGAGAAAACAGCAAAACAAG CTAAAAGACCTTTCCCCAATTGCGGAGCGTCTGGGATGCACACTACCTCAGCTAGCTGTT GCGTGGTGCCTGAGAAATGAAGGTGTGAGTTCTGTGCTCCTGGGATCATCCACTCCTGAA CAACTCATTGAAAACCTTGGTGCCATTCAGGTTCTCCCAAAGATGACATCACATGTGGTA AATGAGATTGATAACATACTGCGCAACAAGCCCTACAGCAAGAAGGACTATAGATCATAA
- Chromosome Location
- 3
- Locus
- 3q25.31
- External Identifiers
Resource Link UniProtKB ID Q14722 UniProtKB Entry Name KCAB1_HUMAN HGNC ID HGNC:6228 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details DB01069 Promethazine approved, investigational unknown inducer Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details