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Identification
NameClindamycin
Accession NumberDB01190  (APRD00566)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Structure
Thumb
Synonyms
7-CDL
7(S)-Chloro-7-deoxylincomycin
Cleocin (tn)
Clindamicina
Clindamycin
Clindamycine
Clindamycinum
Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Auro-clindamycincapsule300 mgoralAuro Pharma Inc2015-03-02Not applicableCanada
Auro-clindamycincapsule150 mgoralAuro Pharma Inc2015-03-02Not applicableCanada
Ava-clindamycincapsule300 mgoralAvanstra Inc2011-08-222014-08-21Canada
Ava-clindamycincapsule150 mgoralAvanstra Inc2011-08-222014-08-21Canada
Cleocinsuppository100 mg/1vaginalPharmacia And Upjohn Company Llc1999-08-13Not applicableUs
Cleocinsuppository100 mg/1vaginalU.S. Pharmaceuticals1999-08-13Not applicableUs
Cleocincream20 mg/gvaginalPharmacia And Upjohn Company Llc1992-08-11Not applicableUs
Cleocin Hydrochloridecapsule150 mg/1oralPharmacia And Upjohn Company Llc1970-05-22Not applicableUs
Cleocin Hydrochloridecapsule75 mg/1oralPharmacia And Upjohn Company Llc1970-05-22Not applicableUs
Cleocin Hydrochloridecapsule300 mg/1oralPharmacia And Upjohn Company Llc1970-05-22Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc2014-04-10Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc1972-10-02Not applicableUs
Cleocin Phosphateinjection, solution12 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc2014-09-26Not applicableUs
Cleocin Phosphateinjection, solution12 mg/mLintravenousPharmacia And Upjohn Company Llc1990-08-30Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc2014-04-10Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc1972-10-02Not applicableUs
Cleocin Phosphateinjection, solution18 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc2014-09-26Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2012-10-19Not applicableUs
Cleocin Phosphateinjection, solution6 mg/mLintravenousPharmacia And Upjohn Company Llc1990-08-30Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc2014-04-10Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc1972-10-02Not applicableUs
Cleocin Phosphateinjection, solution18 mg/mLintravenousPharmacia And Upjohn Company Llc1990-08-30Not applicableUs
Cleocin Phosphateinjection, solution6 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc2014-09-26Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintramuscular; intravenousPharmacia And Upjohn Company Llc1972-10-02Not applicableUs
Cleocin Tsolution10 mg/mLtopicalPharmacia And Upjohn Company Llc1980-06-20Not applicableUs
Cleocin Tlotion10 mg/mLtopicalPharmacia And Upjohn Company Llc1989-05-31Not applicableUs
Cleocin Tgel10 mg/gtopicalPharmacia And Upjohn Company Llc1987-01-07Not applicableUs
Clinda-Tsolution1 %topicalValeant Canada Lp/valeant Canada s.e.c.2007-07-25Not applicableCanada
Clindagelgel1 g/10mLtopicalOnset Dermatologics LLC2013-11-25Not applicableUs
Clindamycincapsule150 mgoralSanis Health Inc2013-02-13Not applicableCanada
Clindamycincapsule300 mgoralSanis Health Inc2013-02-13Not applicableCanada
Clindamycin Hydrochloridecapsule150 mg/1oralKAISER FOUNDATION HOSPITALS2009-09-01Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralGreenstone LLC1970-05-22Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralKAISER FOUNDATION HOSPITALS2009-09-01Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralGreenstone LLC1970-05-22Not applicableUs
Clindamycin Injectionsolution150 mgintramuscular; intravenousFresenius Kabi Canada Ltd1995-12-31Not applicableCanada
Clindamycin Injection Sdzliquid150 mgintramuscular; intravenousSandoz Canada Incorporated2012-07-26Not applicableCanada
Clindamycin Injection USPliquid150 mgintramuscular; intravenousSandoz Canada Incorporated1999-01-19Not applicableCanada
Clindamycin Injection USPliquid150 mgintravenousSandoz Canada Incorporated1999-01-15Not applicableCanada
Clindamycin Injection, USPsolution150 mgintramuscular; intravenousAbbott Laboratories, Limited1995-12-312007-07-31Canada
Clindamycin Injection, USPsolution150 mgintramuscular; intravenousMylan Pharmaceuticals UlcNot applicableNot applicableCanada
Clindamycin IV Infusionsolution12 mgintravenousSandoz Canada Incorporated2013-12-05Not applicableCanada
Clindamycin IV Infusionsolution18 mgintravenousSandoz Canada Incorporated2013-12-05Not applicableCanada
Clindamycin IV Infusionsolution6 mgintravenousSandoz Canada IncorporatedNot applicableNot applicableCanada
Clindamycin Phosphatesolution10 mg/mLtopicalGreenstone LLC1980-06-20Not applicableUs
Clindamycin Phosphategel10 mg/gtopicalGreenstone LLC1987-01-07Not applicableUs
Clindamycin Phosphatelotion10 mg/mLtopicalGreenstone LLC1989-05-31Not applicableUs
Clindamycin Phosphatecream20 mg/gvaginalGreenstone LLC1992-08-11Not applicableUs
Clindamycin Phosphate Injection USP Liqliquid150 mgintramuscular; intravenousLyphomed, Division Of Fujisawa Canada Inc.1994-12-311996-09-10Canada
Clindamycine-150capsule150 mgoralPro Doc Limitee2003-12-10Not applicableCanada
Clindamycine-300capsule300 mgoralPro Doc Limitee2003-12-10Not applicableCanada
Clindessecream100 mg/5gvaginalPerrigo New York Inc2015-07-03Not applicableUs
Clindessecream20 mg/gvaginalTher Rx Corporation2009-11-01Not applicableUs
Clindetspad1 %topicalGlaxosmithkline Inc2002-06-10Not applicableCanada
Dalacin C 150 mgcapsule150 mgoralPfizer Canada Inc1970-12-31Not applicableCanada
Dalacin C 300 mgcapsule300 mgoralPfizer Canada Inc1995-12-31Not applicableCanada
Dalacin C Flavoured Granulespowder for solution75 mgoralPfizer Canada Inc1972-12-31Not applicableCanada
Dalacin C Phosphatesolution150 mgintramuscular; intravenousPfizer Canada Inc1973-12-31Not applicableCanada
Dalacin T 1%solution1 %topicalPfizer Canada Inc1991-12-31Not applicableCanada
Dalacin Vaginal Cream 20 mgcream20 mgvaginalPfizer Canada Inc1994-12-31Not applicableCanada
Evoclinaerosol, foam10 mg/gtopicalPrestium Pharma, Inc.2014-08-19Not applicableUs
Mylan-clindamycincapsule300 mgoralMylan Pharmaceuticals Ulc2004-09-14Not applicableCanada
Mylan-clindamycincapsule150 mgoralMylan Pharmaceuticals Ulc2004-09-14Not applicableCanada
Nu-clindamycincapsule150 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-clindamycincapsule300 mgoralNu Pharm IncNot applicableNot applicableCanada
PMS-clindamycincapsule150 mgoralPharmascience Inc2007-12-18Not applicableCanada
PMS-clindamycincapsule300 mgoralPharmascience Inc2007-12-18Not applicableCanada
Ran-clindamycincapsule300 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ran-clindamycincapsule150 mgoralRanbaxy Pharmaceuticals Canada Inc.Not applicableNot applicableCanada
Ratio-clindamycin Capsules - 300mgcapsule300 mgoralRatiopharm Inc Division Of Teva Canada Limited2000-02-242010-08-02Canada
Ratio-clindamycin Capsules-150mgcapsule150 mgoralRatiopharm Inc Division Of Teva Canada Limited2000-02-242010-08-02Canada
Riva-clindamycincapsule150 mgoralLaboratoire Riva Inc2000-08-142013-07-31Canada
Riva-clindamycincapsule300 mgoralLaboratoire Riva Inc2000-08-142013-07-31Canada
Riva-clindamycincapsule150 mgoralLaboratoire Riva Inc2009-08-312016-05-31Canada
Riva-clindamycincapsule300 mgoralLaboratoire Riva Inc2009-08-312016-05-31Canada
Taro-clindamycinsolution1 %topicalTaro Pharmaceuticals Inc2005-10-03Not applicableCanada
Teva-clindamycincapsule150 mgoralTeva Canada Limited2000-02-18Not applicableCanada
Teva-clindamycincapsule300 mgoralTeva Canada Limited2000-02-18Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-clindamycincapsule150 mgoralApotex Inc2002-02-20Not applicableCanada
Apo-clindamycincapsule300 mgoralApotex Inc2002-02-20Not applicableCanada
Cleocingranule, for solution75 mg/5mLoralPhysicians Total Care, Inc.2007-11-28Not applicableUs
Cleocin Pediatricgranule, for solution75 mg/5mLoralPharmacia And Upjohn Company Llc1986-04-17Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintravenousPharmacia And Upjohn Company Llc1987-10-16Not applicableUs
Cleocin Phosphateinjection, solution150 mg/mLintravenousPharmacia And Upjohn Company Llc1987-10-16Not applicableUs
Cleocin Phosphate (0009-6582) (standalone)injection, solution150 mg/mLintravenousPharmacia And Upjohn Company Llc1987-10-16Not applicableUs
Clin-single Use Kitkitintramuscular; intravenousBurke Therapeutics, LLC2015-08-11Not applicableUs
Clindacin Etzswab10 mg/1topicalMedimetriks Pharmaceuticals, Inc.2013-06-15Not applicableUs
Clindacin EtzkitMedimetriks Pharmaceuticals, Inc.2013-06-15Not applicableUs
Clindacin Pswab10 mg/1topicalMedimetriks Pharmaceuticals, Inc.2011-02-20Not applicableUs
Clindacin Pacswab10 mg/1topicalMedimetriks Pharmaceuticals, Inc.2011-02-20Not applicableUs
Clindamaxcream20 mg/gvaginalPHARMADERM. A division of Nycomed US Inc.2009-10-29Not applicableUs
Clindamaxgel10 mg/gtopicalPharma Derm, A Division Of Nycomed Us Inc.2009-10-01Not applicableUs
Clindamax Lotionsuspension10 mg/mLtopicalPharma Derm, A Division Of Nycomed Us Inc.2002-01-31Not applicableUs
Clindamycininjection, solution150 mg/mLintramuscular; intravenousCardinal Health2012-05-15Not applicableUs
Clindamycininjection, solution150 mg/mLintravenousSagent Pharmaceuticals2012-05-15Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousAlvogen Inc.2015-11-13Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousAlvogen Inc.2016-03-15Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousHospira, Inc.1987-07-24Not applicableUs
Clindamycininjection600 mg/50mLintravenousAkorn, Inc.2013-04-05Not applicableUs
Clindamycininjection, solution150 mg/mLintramuscular; intravenousHospira, Inc.1987-07-24Not applicableUs
Clindamycininjection150 mg/mLintramuscular; intravenousGENERAL INJECTABLES AND VACCINES, INC.2016-03-02Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousAlvogen Inc.2015-11-30Not applicableUs
Clindamycininjection900 mg/50mLintravenousAkorn, Inc.2013-04-05Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousAlvogen Inc.2016-01-27Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousHospira, Inc.1987-07-24Not applicableUs
Clindamycininjection, solution150 mg/mLintramuscular; intravenousHospira, Inc.1987-07-24Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousCardinal Health2011-06-09Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousAlvogen Inc.2016-01-21Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousHospira, Inc.1988-09-29Not applicableUs
Clindamycininjection, solution150 mg/mLintramuscular; intravenousHospira, Inc.1987-07-24Not applicableUs
Clindamycininjection, solution150 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-01-03Not applicableUs
Clindamycininjection, solution150 mg/mLintravenousFresenius Kabi USA, LLC2009-11-22Not applicableUs
Clindamycininjection, solution, concentrate150 mg/mLintravenousHospira, Inc.1987-07-24Not applicableUs
Clindamycininjection300 mg/50mLintravenousAkorn, Inc.2013-04-05Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralREMEDYREPACK INC.2013-09-26Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralCardinal Health2007-08-06Not applicableUs
Clindamycin Hydrochloridecapsule, gelatin coated150 mg/1oralContract Pharmacy Services Pa2010-07-02Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralProficient Rx LP2003-03-182016-03-31Us
Clindamycin Hydrochloridecapsule150 mg/1oralMajor Pharmaceuticals2009-04-10Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralUnit Dose Services2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule, gelatin coated300 mg/1oralCore Pharma, Llc2004-04-15Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralREMEDYREPACK INC.2014-10-24Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralApotheca Inc.2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralSTAT Rx USA LLC2001-02-02Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralPhysicians Total Care, Inc.1998-09-29Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralClinical Solutions Wholesale2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralPreferred Pharmaceuticals, Inc.2013-09-19Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralbryant ranch prepack1991-07-31Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralKAISER FOUNDATION HOSPITALS2014-03-11Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralNorthwind Pharmaceuticals2014-06-17Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralAurobindo Pharma Limited2009-08-26Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralProficient Rx LP2009-08-26Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralAvera Mc Kennan Hospital2015-06-08Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralAidarex Pharmaceuticals LLC2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralREMEDYREPACK INC.2014-03-11Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralPd Rx Pharmaceuticals, Inc.1991-07-31Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralRed Pharm Drug Inc.2006-11-01Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralRanbaxy Pharmaceuticals Inc.2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule75 mg/1oralMylan Pharmaceuticals Inc.2013-05-07Not applicableUs
Clindamycin Hydrochloridecapsule75 mg/1oralLannett Company, Inc.2005-08-12Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralUnit Dose Services2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralDIRECT RX2015-01-01Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-16Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralActavis Pharma, Inc.2014-09-09Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralStat Rx USA2001-02-02Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralPd Rx Pharmaceuticals, Inc.1991-07-31Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-11-08Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralClinical Solutions Wholesale2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralPreferred Pharmaceuticals, Inc.2011-11-08Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralbryant ranch prepack2003-03-18Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralKAISER FOUNDATION HOSPITALS2014-03-11Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralREMEDYREPACK INC.2010-12-16Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralREMEDYREPACK INC.2013-05-15Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralProficient Rx LP2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralTeva Pharmaceuticals USA Inc1990-09-302015-11-30Us
Clindamycin Hydrochloridecapsule150 mg/1oralLannett Company, Inc.2005-08-12Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralBlenheim Pharmacal, Inc.2010-11-01Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralAidarex Pharmaceuticals LLC2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralREMEDYREPACK INC.2011-07-11Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralREMEDYREPACK INC.2014-05-13Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralPd Rx Pharmaceuticals, Inc.2003-03-18Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralAmerican Health Packaging2008-04-22Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralRanbaxy Pharmaceuticals Inc.2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralMylan Pharmaceuticals Inc.2013-05-07Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralRebel Distributors Corp2001-02-02Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralMylan Institutional Inc.2000-05-01Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralPhysicians Total Care, Inc.2005-04-19Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralDIRECT RX2014-01-01Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralPreferred Pharmaceuticals, Inc.2012-01-16Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralG&W Laboratories, Inc.2016-03-14Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralActavis Pharma, Inc.2003-03-182016-03-31Us
Clindamycin Hydrochloridecapsule150 mg/1oralPd Rx Pharmaceuticals, Inc.2005-08-12Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralAv Pak2014-07-15Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralPreferred Pharmaceuticals, Inc.2013-03-08Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2007-08-06Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralTeva Pharmaceuticals USA Inc2005-08-092015-10-31Us
Clindamycin Hydrochloridecapsule150 mg/1oralA S Medication Solutions2009-08-26Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralKAISER FOUNDATION HOSPITALS2014-11-11Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralREMEDYREPACK INC.2011-04-06Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralMedsource Pharmaceuticals2009-08-26Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralREMEDYREPACK INC.2013-05-232016-04-05Us
Clindamycin Hydrochloridecapsule150 mg/1oralCardinal Health1989-09-20Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralContract Pharmacy Services Pa2010-08-09Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralProficient Rx LP2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralMylan Pharmaceuticals Inc.2013-05-07Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralLannett Company, Inc.2005-08-12Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralBlenheim Pharmacal, Inc.2012-11-02Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-11-08Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralAmerican Health Packaging2008-04-22Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralLiberty Pharmaceuticals, Inc.2001-03-23Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralRebel Distributors Corp2001-02-02Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralNorthwind Pharmaceuticals2014-06-01Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralAurobindo Pharma Limited2009-08-26Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralDIRECT RX2015-01-01Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralG&W Laboratories, Inc.2016-03-14Not applicableUs
Clindamycin Hydrochloridecapsule, gelatin coated150 mg/1oralCore Pharma, Llc2004-04-15Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralLake Erie Medical DBA Quality Care Products LLC2014-09-09Not applicableUs
Clindamycin Hydrochloridecapsule150 mg/1oralActavis Pharma, Inc.1991-07-31Not applicableUs
Clindamycin Hydrochloridecapsule300 mg/1oralAv Pak2014-07-15Not applicableUs
Clindamycin In 5 Percent Dextroseinjection, solution6 mg/mLintravenousSandoz Inc2014-03-01Not applicableUs
Clindamycin In 5 Percent Dextroseinjection, solution6 mg/mLintravenousSandoz Inc2013-02-07Not applicableUs
Clindamycin In 5 Percent Dextroseinjection, solution12 mg/mLintravenousSandoz Inc2014-03-01Not applicableUs
Clindamycin In 5 Percent Dextroseinjection, solution12 mg/mLintravenousSandoz Inc2013-02-07Not applicableUs
Clindamycin In 5 Percent Dextroseinjection, solution18 mg/mLintravenousSandoz Inc2014-03-01Not applicableUs
Clindamycin In 5 Percent Dextroseinjection, solution18 mg/mLintravenousSandoz Inc2013-02-07Not applicableUs
Clindamycin Palmitate Hydrochloridegranule, for solution75 mg/5mLoralPaddock Laboratories, LLC2010-01-21Not applicableUs
Clindamycin Palmitate Hydrochloridegranule, for solution75 mg/5mLoralREMEDYREPACK INC.2016-04-13Not applicableUs
Clindamycin Palmitate Hydrochloridesolution75 mg/5mLoralMarlex Pharmaceuticals Inc2015-08-01Not applicableUs
Clindamycin Palmitate Hydrochloridepowder, for solution75 mg/5mLoralAmneal Pharmaceuticals of New York, LLC2013-09-02Not applicableUs
Clindamycin Palmitate Hydrochloridesolution75 mg/5mLoralGreenstone LLC1971-09-16Not applicableUs
Clindamycin Palmitate Hydrochloride (pediatric)granule, for solution75 mg/5mLoralLyne Laboratories, Inc.2012-09-11Not applicableUs
Clindamycin Palmitate Hydrochloride (pediatric)granule, for solution75 mg/5mLoralRising Pharmaceuticals, Inc.2012-10-01Not applicableUs
Clindamycin Palmitate Hydrochloride (pediatric)solution75 mg/5mLoralAurobindo Pharma Limited2013-04-30Not applicableUs
Clindamycin Palmitate Hydrochloride (pediatric)solution75 mg/5mLoralNorth Star Rx Llc2013-04-30Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalActavis Pharma, Inc.2015-01-15Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalPhysicians Total Care, Inc.2003-06-04Not applicableUs
Clindamycin Phosphatecream20 mg/gvaginalPreferred Pharmaceuticals, Inc.2012-03-29Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.1997-06-05Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalQualitest Pharmaceuticals2015-08-15Not applicableUs
Clindamycin Phosphategel10 mg/gtopicalLake Erie Medical DBA Quality Care Products LLC2010-01-28Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalRebel Distributors Corp1997-06-05Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalPerrigo New York Inc2013-09-17Not applicableUs
Clindamycin Phosphatelotion10 mg/mLtopicalPhysicians Total Care, Inc.2003-06-03Not applicableUs
Clindamycin Phosphategel10 mg/gtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2010-01-28Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalPhysicians Total Care, Inc.2002-01-11Not applicableUs
Clindamycin Phosphateaerosol, foam10 mg/gtopicalPerrigo New York Inc2010-03-31Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalTaro Pharmaceuticals U.S.A., Inc.2004-03-31Not applicableUs
Clindamycin Phosphatelotion10 mg/mLtopicalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2002-01-31Not applicableUs
Clindamycin Phosphateinjection, solution150 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.1997-02-27Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalAv Kare, Inc.2015-09-29Not applicableUs
Clindamycin Phosphatecream20 mg/gvaginalE. Fougera & Co. a division of Fougera Pharmaceuticals Inc.2004-12-27Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalPerrigo New York Inc2006-05-31Not applicableUs
Clindamycin Phosphatecream20 mg/gvaginalPhysicians Total Care, Inc.2005-05-19Not applicableUs
Clindamycin Phosphategel10 mg/gtopicalPreferred Pharmaceuticals, Inc.2012-07-27Not applicableUs
Clindamycin Phosphategel10 mg/gtopicalPhysicians Total Care, Inc.2005-04-07Not applicableUs
Clindamycin Phosphatesolution10 mg/mLtopicalVersa Pharm Incorporated2010-07-10Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ClinimycinHayat
Dalacin CPfizer
Dalacin T Topical SolutionPfizer
ZindaclinCrawford
Brand mixtures
NameLabellerIngredients
AcanyaCoria Laboratories
BenzaclinValeant Pharmaceuticals North America LLC
Benzaclin Topical GelValeant Canada Lp Valeant Canada S.E.C.
Biacna Topical GelValeant Canada Lp Valeant Canada S.E.C.
Clindamycin - Benzoyl PeroxidePrasco Laboratories
Clindamycin and Benzoyl PeroxidePerrigo New York Inc
Clindamycin Phosphate and Benzoyl PeroxideMylan Pharmaceuticals Inc.
ClindasolGlaxosmithkline Inc
Clindoxyl Adv GelGlaxosmithkline Inc
Clindoxyl GelGlaxosmithkline Inc
DuacStiefel Laboratories Inc
NeuacMedimetriks Pharmaceuticals
Neuac KitMedimetriks Pharmaceuticals
OnextonValeant Pharmaceuticals North America LLC
Taro-clindamycin/benzoyl Peroxide GelTaro Pharmaceuticals Inc
VeltinStiefel Laboratories Inc
ZianaMedicis Pharmaceutical Corp
Salts
Name/CASStructureProperties
Clindamycin hydrochloride
ThumbNot applicableDBSALT001163
Clindamycin palmitate hydrochloride
ThumbNot applicableDBSALT001215
Clindamycin phosphate
24729-96-2
Thumb
  • InChI Key: UFUVLHLTWXBHGZ-KUWMELJBSA-N
  • Monoisotopic Mass: 504.146200983
  • Average Mass: 504.963
DBSALT000778
Categories
UNII3U02EL437C
CAS number18323-44-9
WeightAverage: 424.983
Monoisotopic: 424.179870573
Chemical FormulaC18H33ClN2O5S
InChI KeyInChIKey=KDLRVYVGXIQJDK-NOWPCOIGSA-N
InChI
InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9?,10-,11+,12?,13+,14-,15-,16-,18-/m1/s1
IUPAC Name
(2S,4R)-N-{2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl}-1-methyl-4-propylpyrrolidine-2-carboxamide
SMILES
CCC[C@@H]1C[[email protected]](N(C)C1)C(=O)NC(C(C)Cl)[[email protected]]1O[[email protected]](SC)[[email protected]](O)[C@@H](O)[[email protected]]1O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • S-glycosyl compound
  • Glycosyl compound
  • Pyrrolidine-2-carboxamide
  • Pyrrolidine carboxylic acid or derivatives
  • N-alkylpyrrolidine
  • Oxane
  • Monosaccharide
  • Saccharide
  • Pyrrolidine
  • Monothioacetal
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Polyol
  • Carboxamide group
  • 1,2-diol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Sulfenyl compound
  • Thioether
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organochloride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Alkyl halide
  • Alkyl chloride
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of serious infections caused by susceptible anaerobic bacteria, including Bacteroides spp., Peptostreptococcus, anaerobic streptococci, Clostridium spp., and microaerophilic streptococci. May be useful in polymicrobic infections such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, aspiration pneumonia and dental infections. May also be used to treat MSSA and respiratory infections caused by S. pneumoniae and S. pyogenes in patients who are intolerant to other indicated antibiotics or who are infected with resistant organism. May be used vaginally to treat vaginosis caused by Gardnerella vaginosa. Clindamycin reduces the toxin producing effects of S. aureus and S. pyogenes and as such, may be particularly useful for treating necrotizing fasciitis. May be used topically to treat acne.
PharmacodynamicsClindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Mechanism of actionSystemic/vaginal clindamycin inhibits protein synthesis of bacteria by binding to the 50S ribosomal subunits of the bacteria. Specifically, it binds primarily to the 23s RNA subunit. Topical clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes) , an anaerobe found in sebaceous glands and follicles.
Related Articles
AbsorptionRapidly absorbed after oral administration with peak serum concentrations observed after about 45 minutes. Absorption of an oral dose is virtually complete (90%) and the concomitant intake of food does not appreciably modify the serum concentrations; serum levels have been uniform and predictable from person to person and dose to dose. Clindamycin does not penetrate the blood brain barrier.
Volume of distributionNot Available
Protein binding92-94%
Metabolism

Hepatic

Route of eliminationApproximately 10% of the bioactivity is excreted in the urine and 3.6% in the feces; the remainder is excreted as bioinactive metabolites.
Half life2.4 hours
ClearanceNot Available
ToxicityAdverse effects include nausea (may be dose-limiting), diarrhea, pseudomembranous colitis, allergic reactions, hepatoxicity, transient neutropenia and eosinophilia and agranulocytosis. Pseudomembranous colitis occurs in 0.01 - 10% of patients and occurs more commonly than with other antibiotics. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Affected organisms
  • Enteric bacteria and other eubacteria
Pathways
PathwayCategorySMPDB ID
Clindamycin Action PathwayDrug actionSMP00249
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8143
Blood Brain Barrier-0.9697
Caco-2 permeable-0.8236
P-glycoprotein substrateSubstrate0.7653
P-glycoprotein inhibitor INon-inhibitor0.7311
P-glycoprotein inhibitor IIInhibitor0.7894
Renal organic cation transporterNon-inhibitor0.8784
CYP450 2C9 substrateNon-substrate0.8214
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6762
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8876
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9107
Ames testNon AMES toxic0.6967
CarcinogenicityNon-carcinogens0.9172
BiodegradationNot ready biodegradable0.994
Rat acute toxicity2.3192 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9887
hERG inhibition (predictor II)Non-inhibitor0.59
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Suppositoryvaginal100 mg/1
Injection, solutionintramuscular; intravenous12 mg/mL
Injection, solutionintramuscular; intravenous18 mg/mL
Injection, solutionintramuscular; intravenous6 mg/mL
Kitintramuscular; intravenous
Kit
Swabtopical10 mg/1
Geltopical1 g/10mL
Suspensiontopical10 mg/mL
Injectionintramuscular; intravenous150 mg/mL
Injectionintravenous300 mg/50mL
Injectionintravenous600 mg/50mL
Injectionintravenous900 mg/50mL
Injection, solutionintramuscular; intravenous150 mg/mL
Injection, solutionintravenous150 mg/mL
Injection, solution, concentrateintravenous150 mg/mL
Capsuleoral150 mg/1
Capsuleoral300 mg/1
Capsuleoral75 mg/1
Capsule, gelatin coatedoral150 mg/1
Capsule, gelatin coatedoral300 mg/1
Injection, solutionintravenous12 mg/mL
Injection, solutionintravenous18 mg/mL
Injection, solutionintravenous6 mg/mL
Liquidintramuscular; intravenous150 mg
Liquidintravenous150 mg
Solutionintravenous12 mg
Solutionintravenous18 mg
Solutionintravenous6 mg
Powder, for solutionoral75 mg/5mL
Solutionoral75 mg/5mL
Granule, for solutionoral75 mg/5mL
Creamvaginal20 mg/g
Geltopical10 mg/g
Lotiontopical10 mg/mL
Solutiontopical10 mg/mL
Kit
Creamtopical
Creamvaginal100 mg/5g
Padtopical1 %
Powder for solutionoral75 mg
Solutionintramuscular; intravenous150 mg
Solutiontopical1 %
Creamvaginal20 mg
Aerosol, foamtopical10 mg/g
Kittopical
Capsuleoral150 mg
Capsuleoral300 mg
Geltopical
Prices
Unit descriptionCostUnit
Clindagel 1% Gel 75ml Bottle324.48USD bottle
Evoclin 1% Foam 100 gm Can306.79USD can
Clindamycin Phosphate 1% Foam 100 gm Can286.04USD can
Evoclin 1% Foam 50 gm Can207.67USD can
Clindagel 1% Gel 40ml Bottle203.42USD bottle
Clindamycin Phosphate 1% Foam 50 gm Can186.9USD can
Clindamycin Phos-Benzoyl Perox 1-5% Gel 50 gm Jar176.42USD jar
Cleocin-T 1% Gel 60 gm Tube112.84USD tube
Cleocin-T 1% Lotion 60ml Bottle86.09USD bottle
Cleocin-T 60 1% Swab Box82.6USD box
Cleocin 2% Cream 40 gm Tube81.56USD tube
Cleocin 3 100 mg Suppository Box80.05USD box
Cleocin 75 mg/5ml Solution 100ml Bottle78.7USD bottle
Clindamycin hcl crystals74.9USD g
Clindamycin Phosphate 1% Gel 60 gm Tube71.42USD tube
Cleocin-T 1% Solution 60ml Bottle69.29USD bottle
Cleocin-T 1% Gel 30 gm Tube62.98USD tube
Clindamycin Phosphate 2% Cream 40 gm Tube54.99USD tube
Clindamycin Phosphate 60 1% Swab Box47.74USD box
Clindamycin Phosphate 1% Lotion 60ml Bottle46.92USD bottle
Clindesse 2% vaginal cream39.08USD g
Clindamycin Phosphate 1% Gel 30 gm Tube33.41USD tube
Clindamycin Phosphate 1% Solution 60ml Bottle24.07USD bottle
Clindamycin phosphate powdr21.42USD g
Clindamycin Phosphate 1% Solution 30ml Bottle14.99USD bottle
Cleocin hcl 300 mg capsule9.11USD capsule
Clindamycin phos crystals7.73USD g
Evoclin 1% foam4.9USD g
Clindagel 1% gel4.89USD ml
Cleocin 150 mg capsule4.66USD capsule
Dalacin C Phosphate 150 mg/ml4.53USD ml
Clindamycin hcl 300 mg capsule3.98USD capsule
Clindamycin phosphate 1% foam3.59USD g
Clindamycin 150 mg/ml3.48USD ml
Clindamycin (60 & 120 Ml) 150 mg/ml3.41USD ml
Cleocin hcl 150 mg capsule2.79USD capsule
Cleocin hcl 75 mg capsule2.28USD capsule
Dalacin C 300 mg Capsule2.12USD capsule
Cleocin 2% vaginal cream1.97USD g
Clindamycin 150 mg/ml addvan1.97USD ml
Cleocin phos 150 mg/ml vial1.91USD ml
Cleocin t 1% gel1.81USD g
Clindamycin ph 300 mg/2 ml vial1.74USD ml
Clindamax 2% vaginal cream1.37USD g
Clindamycin 2% vaginal cream1.27USD g
Clindamycin hcl 150 mg capsule1.21USD capsule
Clindets 1% pledgets1.1USD each
Dalacin C 150 mg Capsule1.06USD capsule
Apo-Clindamycin 300 mg Capsule1.02USD capsule
Mylan-Clindamycin 300 mg Capsule1.02USD capsule
Novo-Clindamycin 300 mg Capsule1.02USD capsule
Clindamycin ph 9 g/60 ml vial0.93USD ml
Apo-Clindamycin 150 mg Capsule0.51USD capsule
Mylan-Clindamycin 150 mg Capsule0.51USD capsule
Novo-Clindamycin 150 mg Capsule0.51USD capsule
Clinda-derm 1% solution0.4USD ml
Cleocin 900 mg-d5w-galaxy0.37USD ml
Cleocin 600 mg-d5w-galaxy0.3USD ml
Dalacin C Palmitate 15 mg/ml Solution0.14USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5266329 No1993-11-302010-11-30Us
US5993856 No1997-11-172017-11-17Us
US6387383 No2000-08-032020-08-03Us
US6495157 No2000-07-202020-07-20Us
US6899890 No2003-04-272023-04-27Us
US7141237 No2004-01-232024-01-23Us
US7374747 No2006-08-092026-08-09Us
US8288434 No2009-08-052029-08-05Us
US8663699 No2009-06-032029-06-03Us
US8895070 No2009-06-032029-06-03Us
US9078870 No2009-06-032029-06-03Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point142 [HCl salt]Not Available
water solubility30.6 mg/LNot Available
logP2.16HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility3.1 mg/mLALOGPS
logP1.76ALOGPS
logP1.04ChemAxon
logS-2.1ALOGPS
pKa (Strongest Acidic)12.16ChemAxon
pKa (Strongest Basic)7.55ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area102.26 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity105.72 m3·mol-1ChemAxon
Polarizability44.49 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

Donald E. Ayer, Carl A. Schlagel, Gordon L. Flynn, “Topical clindamycin preparations.” U.S. Patent US4018918, issued January, 1971.

US4018918
General References
  1. Daum RS: Clinical practice. Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med. 2007 Jul 26;357(4):380-90. [PubMed:17652653 ]
  2. Klempner MS, Styrt B: Clindamycin uptake by human neutrophils. J Infect Dis. 1981 Nov;144(5):472-9. [PubMed:6171600 ]
  3. Lamont RF: Can antibiotics prevent preterm birth--the pro and con debate. BJOG. 2005 Mar;112 Suppl 1:67-73. [PubMed:15715599 ]
  4. Plaisance KI, Drusano GL, Forrest A, Townsend RJ, Standiford HC: Pharmacokinetic evaluation of two dosage regimens of clindamycin phosphate. Antimicrob Agents Chemother. 1989 May;33(5):618-20. [PubMed:2751277 ]
External Links
ATC CodesJ01FF01G01AA10D10AF01D10AF51
AHFS Codes
  • 08:12.28.20
  • 84:04.04
PDB EntriesNot Available
FDA labelDownload (151 KB)
MSDSDownload (72.8 KB)
Interactions
Drug Interactions
Drug
AmiodaroneThe metabolism of Clindamycin can be decreased when combined with Amiodarone.
AprepitantThe serum concentration of Clindamycin can be increased when it is combined with Aprepitant.
AtazanavirThe metabolism of Clindamycin can be decreased when combined with Atazanavir.
AtomoxetineThe metabolism of Clindamycin can be decreased when combined with Atomoxetine.
BexaroteneThe serum concentration of Clindamycin can be decreased when it is combined with Bexarotene.
BoceprevirThe metabolism of Clindamycin can be decreased when combined with Boceprevir.
BortezomibThe metabolism of Clindamycin can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Clindamycin can be decreased when it is combined with Bosentan.
CarbamazepineThe metabolism of Clindamycin can be increased when combined with Carbamazepine.
CeritinibThe serum concentration of Clindamycin can be increased when it is combined with Ceritinib.
ClarithromycinThe metabolism of Clindamycin can be decreased when combined with Clarithromycin.
ClemastineThe metabolism of Clindamycin can be decreased when combined with Clemastine.
ClotrimazoleThe metabolism of Clindamycin can be decreased when combined with Clotrimazole.
CobicistatThe metabolism of Clindamycin can be decreased when combined with Cobicistat.
ConivaptanThe serum concentration of Clindamycin can be increased when it is combined with Conivaptan.
CrizotinibThe metabolism of Clindamycin can be decreased when combined with Crizotinib.
CyclosporineThe metabolism of Clindamycin can be decreased when combined with Cyclosporine.
DabrafenibThe serum concentration of Clindamycin can be decreased when it is combined with Dabrafenib.
DarunavirThe metabolism of Clindamycin can be decreased when combined with Darunavir.
DasatinibThe serum concentration of Clindamycin can be increased when it is combined with Dasatinib.
DeferasiroxThe serum concentration of Clindamycin can be decreased when it is combined with Deferasirox.
DelavirdineThe metabolism of Clindamycin can be decreased when combined with Delavirdine.
DexamethasoneThe serum concentration of Clindamycin can be decreased when it is combined with Dexamethasone.
DihydroergotamineThe metabolism of Clindamycin can be decreased when combined with Dihydroergotamine.
DiltiazemThe metabolism of Clindamycin can be decreased when combined with Diltiazem.
DoxycyclineThe metabolism of Clindamycin can be decreased when combined with Doxycycline.
DronedaroneThe metabolism of Clindamycin can be decreased when combined with Dronedarone.
EfavirenzThe serum concentration of Clindamycin can be decreased when it is combined with Efavirenz.
EnzalutamideThe serum concentration of Clindamycin can be decreased when it is combined with Enzalutamide.
ErythromycinThe therapeutic efficacy of Clindamycin can be decreased when used in combination with Erythromycin.
Eslicarbazepine acetateThe serum concentration of Clindamycin can be decreased when it is combined with Eslicarbazepine acetate.
EtravirineThe serum concentration of Clindamycin can be decreased when it is combined with Etravirine.
FluconazoleThe metabolism of Clindamycin can be decreased when combined with Fluconazole.
FluvoxamineThe metabolism of Clindamycin can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Clindamycin can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Clindamycin can be increased when it is combined with Fosaprepitant.
FosphenytoinThe metabolism of Clindamycin can be increased when combined with Fosphenytoin.
Fusidic AcidThe serum concentration of Clindamycin can be increased when it is combined with Fusidic Acid.
IdelalisibThe serum concentration of Clindamycin can be increased when it is combined with Idelalisib.
ImatinibThe metabolism of Clindamycin can be decreased when combined with Imatinib.
IndinavirThe metabolism of Clindamycin can be decreased when combined with Indinavir.
IsavuconazoniumThe metabolism of Clindamycin can be decreased when combined with Isavuconazonium.
IsradipineThe metabolism of Clindamycin can be decreased when combined with Isradipine.
ItraconazoleThe metabolism of Clindamycin can be decreased when combined with Itraconazole.
IvacaftorThe serum concentration of Clindamycin can be increased when it is combined with Ivacaftor.
KetoconazoleThe metabolism of Clindamycin can be decreased when combined with Ketoconazole.
LopinavirThe metabolism of Clindamycin can be decreased when combined with Lopinavir.
LovastatinThe metabolism of Clindamycin can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Clindamycin can be increased when it is combined with Luliconazole.
MifepristoneThe metabolism of Clindamycin can be decreased when combined with Mifepristone.
MitotaneThe serum concentration of Clindamycin can be decreased when it is combined with Mitotane.
ModafinilThe serum concentration of Clindamycin can be decreased when it is combined with Modafinil.
NafcillinThe serum concentration of Clindamycin can be decreased when it is combined with Nafcillin.
NefazodoneThe metabolism of Clindamycin can be decreased when combined with Nefazodone.
NelfinavirThe metabolism of Clindamycin can be decreased when combined with Nelfinavir.
NetupitantThe serum concentration of Clindamycin can be increased when it is combined with Netupitant.
NevirapineThe metabolism of Clindamycin can be decreased when combined with Nevirapine.
NilotinibThe metabolism of Clindamycin can be decreased when combined with Nilotinib.
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Clindamycin.
OlaparibThe metabolism of Clindamycin can be decreased when combined with Olaparib.
OsimertinibThe serum concentration of Clindamycin can be increased when it is combined with Osimertinib.
PalbociclibThe serum concentration of Clindamycin can be increased when it is combined with Palbociclib.
PentobarbitalThe metabolism of Clindamycin can be increased when combined with Pentobarbital.
PhenobarbitalThe metabolism of Clindamycin can be increased when combined with Phenobarbital.
PhenytoinThe metabolism of Clindamycin can be increased when combined with Phenytoin.
Picosulfuric acidThe therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Clindamycin.
PosaconazoleThe metabolism of Clindamycin can be decreased when combined with Posaconazole.
PrimidoneThe metabolism of Clindamycin can be increased when combined with Primidone.
RanolazineThe metabolism of Clindamycin can be decreased when combined with Ranolazine.
RifabutinThe metabolism of Clindamycin can be increased when combined with Rifabutin.
RifampicinThe metabolism of Clindamycin can be increased when combined with Rifampicin.
RifapentineThe metabolism of Clindamycin can be increased when combined with Rifapentine.
RitonavirThe metabolism of Clindamycin can be decreased when combined with Ritonavir.
SaquinavirThe metabolism of Clindamycin can be decreased when combined with Saquinavir.
SildenafilThe metabolism of Clindamycin can be decreased when combined with Sildenafil.
SiltuximabThe serum concentration of Clindamycin can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Clindamycin can be increased when it is combined with Simeprevir.
St. John's WortThe serum concentration of Clindamycin can be decreased when it is combined with St. John's Wort.
StiripentolThe serum concentration of Clindamycin can be increased when it is combined with Stiripentol.
SulfisoxazoleThe metabolism of Clindamycin can be decreased when combined with Sulfisoxazole.
TelaprevirThe metabolism of Clindamycin can be decreased when combined with Telaprevir.
TelithromycinThe metabolism of Clindamycin can be decreased when combined with Telithromycin.
TiclopidineThe metabolism of Clindamycin can be decreased when combined with Ticlopidine.
TocilizumabThe serum concentration of Clindamycin can be decreased when it is combined with Tocilizumab.
VenlafaxineThe metabolism of Clindamycin can be decreased when combined with Venlafaxine.
VerapamilThe metabolism of Clindamycin can be decreased when combined with Verapamil.
VoriconazoleThe metabolism of Clindamycin can be decreased when combined with Voriconazole.
ZiprasidoneThe metabolism of Clindamycin can be decreased when combined with Ziprasidone.
Food Interactions
  • Take with food.

Targets

Kind
Protein
Organism
Shigella flexneri
Pharmacological action
yes
Actions
inhibitor
General Function:
Structural constituent of ribosome
Specific Function:
Protein L10 is also a translational repressor protein. It controls the translation of the rplJL-rpoBC operon by binding to its mRNA (By similarity).Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Gene Name:
rplJ
Uniprot ID:
P0A7J6
Molecular Weight:
17711.38 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Schlunzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Yonath A, Franceschi F: Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. [PubMed:11677599 ]
2. 23S rRNA
Kind
Nucleotide
Organism
Enteric bacteria and other eubacteria
Pharmacological action
yes
Actions
inhibitor
References
  1. Schlunzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Yonath A, Franceschi F: Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. [PubMed:11677599 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on September 26, 2016 02:14