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Identification
NameLevetiracetam
Accession NumberDB01202  (APRD01068)
TypeSmall Molecule
GroupsApproved, Investigational
Description

Levetiracetam is an anticonvulsant medication used to treat epilepsy. Levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. Levetiracetam binds to the synaptic vesicle protein SV2A, which is thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of levetiracetam binding to synaptic vesicle protein SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice.

Structure
Thumb
Synonyms
Levetiracetam
Levetiracetame
Levetiracetamum
Levitiracetam
External Identifiers
  • UCB 22059
  • UCB L059
  • UCB-22059
  • UCB-L059
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Abbott-levetiracetamtablet750 mgoralAbbott Laboratories, Limited2014-05-302015-12-31Canada
Abbott-levetiracetamtablet500 mgoralAbbott Laboratories, Limited2014-05-302015-12-31Canada
Abbott-levetiracetamtablet250 mgoralAbbott Laboratories, Limited2014-05-302015-12-31Canada
Act Levetiracetamtablet750 mgoralActavis Pharma Company2005-12-07Not applicableCanada
Act Levetiracetamtablet500 mgoralActavis Pharma Company2005-12-07Not applicableCanada
Act Levetiracetamtablet250 mgoralActavis Pharma Company2005-12-07Not applicableCanada
Auro-levetiracetamtablet750 mgoralAuro Pharma Inc2012-02-14Not applicableCanada
Auro-levetiracetamtablet500 mgoralAuro Pharma Inc2012-03-15Not applicableCanada
Auro-levetiracetamtablet250 mgoralAuro Pharma Inc2012-02-14Not applicableCanada
Ava-levetiracetamtablet750 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-levetiracetamtablet500 mgoralAvanstra Inc2011-10-112014-08-21Canada
Ava-levetiracetamtablet250 mgoralAvanstra Inc2011-10-112014-08-21Canada
Bio-levetiracetamtablet500 mgoralBiomed PharmaNot applicableNot applicableCanada
Bio-levetiracetamtablet250 mgoralBiomed PharmaNot applicableNot applicableCanada
Bio-levetiracetamtablet750 mgoralBiomed PharmaNot applicableNot applicableCanada
Dom-levetiracetamtablet750 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Dom-levetiracetamtablet500 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Dom-levetiracetamtablet250 mgoralDominion Pharmacal2008-04-16Not applicableCanada
Elepsia XRtablet, extended release1500 mg/1oralSun Pharma Advanced Research Company Limited2015-03-13Not applicableUs
Elepsia XRtablet, extended release1000 mg/1oralSun Pharma Advanced Research Company Limited2015-03-13Not applicableUs
Jamp-levetiracetamtablet750 mgoralJamp Pharma Corporation2013-04-29Not applicableCanada
Jamp-levetiracetamtablet500 mgoralJamp Pharma Corporation2013-04-29Not applicableCanada
Jamp-levetiracetamtablet250 mgoralJamp Pharma Corporation2013-04-29Not applicableCanada
Keppratablet, film coated750 mg/1oralPhysicians Total Care, Inc.2005-04-15Not applicableUs
Keppratablet, film coated250 mg/1oralUCB, Inc.2000-04-24Not applicableUs
Keppratablet, film coated500 mg/1oralSTAT Rx USA LLC2000-04-24Not applicableUs
Kepprainjection, solution, concentrate100 mg/mLintravenousCardinal Health2006-07-31Not applicableUs
Keppratablet, film coated500 mg/1oralPhysicians Total Care, Inc.2003-10-30Not applicableUs
Kepprasolution100 mg/mLoralUCB, Inc.2003-10-20Not applicableUs
Keppratablet, film coated750 mg/1oralREMEDYREPACK INC.2013-02-282016-04-05Us
Kepprainjection, solution, concentrate100 mg/mLintravenousUCB, Inc.2006-08-23Not applicableUs
Keppratablet750 mgoralUcb Canada Inc2003-07-23Not applicableCanada
Keppratablet, film coated1000 mg/1oralRx Pak Division Of Mc Kesson Corporation2014-05-16Not applicableUs
Keppratablet1000 mg/1oralUCB Farchim S.A.2000-04-242016-04-05Us
Keppratablet, film coated500 mg/1oralRx Pak Division Of Mc Kesson Corporation2014-05-16Not applicableUs
Keppratablet, film coated1000 mg/1oralUCB, Inc.2000-04-24Not applicableUs
Keppratablet750 mg/1oralUCB Farchim S.A.2000-04-242016-04-05Us
Keppratablet500 mgoralUcb Canada Inc2003-07-23Not applicableCanada
Keppratablet, film coated750 mg/1oralUCB, Inc.2000-04-24Not applicableUs
Keppratablet500 mg/1oralRebel Distributors Corp2000-04-24Not applicableUs
Keppratablet250 mgoralUcb Canada Inc2003-07-23Not applicableCanada
Keppratablet, film coated750 mg/1oralRx Pak Division Of Mc Kesson Corporation2014-05-16Not applicableUs
Keppratablet, film coated500 mg/1oralUCB, Inc.2000-04-24Not applicableUs
Keppratablet, film coated750 mg/1oralSTAT Rx USA LLC2000-04-24Not applicableUs
Keppratablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2000-04-24Not applicableUs
Keppra XRtablet, film coated, extended release750 mg/1oralRx Pak Division Of Mc Kesson Corporation2014-05-16Not applicableUs
Keppra XRtablet, film coated, extended release500 mg/1oralRx Pak Division Of Mc Kesson Corporation2014-05-16Not applicableUs
Keppra XRtablet, film coated, extended release750 mg/1oralUCB, Inc.2009-04-01Not applicableUs
Keppra XRtablet, film coated, extended release500 mg/1oralUCB, Inc.2008-09-24Not applicableUs
Levetiracetaminjection10 mg/mLintravenousMylan Institutional LLC2011-11-10Not applicableUs
Levetiracetamtablet250 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Levetiracetaminjection5 mg/mLintravenousMylan Institutional LLC2011-11-10Not applicableUs
Levetiracetamtablet750 mgoralSivem Pharmaceuticals Ulc2015-07-22Not applicableCanada
Levetiracetamtablet500 mgoralSivem Pharmaceuticals Ulc2015-07-22Not applicableCanada
Levetiracetamtablet750 mgoralSanis Health Inc2010-07-26Not applicableCanada
Levetiracetamtablet500 mgoralSanis Health Inc2010-07-26Not applicableCanada
Levetiracetamtablet250 mgoralSivem Pharmaceuticals Ulc2015-07-22Not applicableCanada
Levetiracetamtablet750 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Levetiracetamtablet250 mgoralSanis Health Inc2010-07-26Not applicableCanada
Levetiracetamtablet500 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Levetiracetamtablet750 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Levetiracetamtablet250 mgoralCobalt Pharmaceuticals CompanyNot applicableNot applicableCanada
Levetiracetaminjection15 mg/mLintravenousMylan Institutional LLC2011-11-10Not applicableUs
Levetiracetamtablet500 mgoralJubilant Generics LimitedNot applicableNot applicableCanada
Levetiracetam Tabletstablet750 mgoralAccord Healthcare Inc2013-03-20Not applicableCanada
Levetiracetam Tabletstablet500 mgoralAccord Healthcare Inc2013-03-20Not applicableCanada
Levetiracetam Tabletstablet250 mgoralAccord Healthcare Inc2013-03-20Not applicableCanada
Nat-levetiracetamtablet750 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-levetiracetamtablet500 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Nat-levetiracetamtablet250 mgoralNatco Pharma (Canada) Inc2015-07-22Not applicableCanada
Novo-levetiracetamtablet750 mgoralNovopharm LimitedNot applicableNot applicableCanada
Nu-levetiracetamtablet250 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-levetiracetamtablet500 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-levetiracetamtablet750 mgoralNu Pharm IncNot applicableNot applicableCanada
PHL-levetiracetamtablet750 mgoralPharmel Inc2008-04-16Not applicableCanada
PHL-levetiracetamtablet500 mgoralPharmel Inc2008-04-16Not applicableCanada
PHL-levetiracetamtablet250 mgoralPharmel Inc2008-04-16Not applicableCanada
PMS-levetiracetamtablet250 mgoralPharmascience Inc2007-06-07Not applicableCanada
PMS-levetiracetamtablet500 mgoralPharmascience Inc2007-06-07Not applicableCanada
PMS-levetiracetamtablet750 mgoralPharmascience Inc2007-06-07Not applicableCanada
Priva-levetiracetamtablet750 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-levetiracetamtablet500 mgoralPharmapar IncNot applicableNot applicableCanada
Priva-levetiracetamtablet250 mgoralPharmapar IncNot applicableNot applicableCanada
Pro-levetiracetam - 250tablet250 mgoralPro Doc Limitee2013-06-06Not applicableCanada
Pro-levetiracetam - 500tablet500 mgoralPro Doc Limitee2009-06-16Not applicableCanada
Pro-levetiracetam - 750tablet750 mgoralPro Doc Limitee2009-10-08Not applicableCanada
Ran-levetiracetamtablet250 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-03-22Not applicableCanada
Ran-levetiracetamtablet750 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-03-22Not applicableCanada
Ran-levetiracetamtablet500 mgoralRanbaxy Pharmaceuticals Canada Inc.2013-03-22Not applicableCanada
Spritamtablet, for suspension250 mg/1oralAprecia Pharmaceuticals Company2016-02-05Not applicableUs
Spritamtablet, for suspension1000 mg/1oralAprecia Pharmaceuticals Company2016-02-05Not applicableUs
Spritamtablet, for suspension750 mg/1oralAprecia Pharmaceuticals Company2016-02-05Not applicableUs
Spritamtablet, for suspension500 mg/1oralAprecia Pharmaceuticals Company2016-02-05Not applicableUs
Torrent-levetiracetamtablet750 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-levetiracetamtablet500 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Torrent-levetiracetamtablet250 mgoralTorrent Pharmaceuticals LimitedNot applicableNot applicableCanada
Van-levetiracetamtablet750 mgoralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Van-levetiracetamtablet500 mgoralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Van-levetiracetamtablet250 mgoralVanc Pharmaceuticals IncNot applicableNot applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-levetiracetamtablet250 mgoralApotex Inc2006-10-20Not applicableCanada
Apo-levetiracetamtablet750 mgoralApotex Inc2006-10-20Not applicableCanada
Apo-levetiracetamtablet500 mgoralApotex Inc2006-10-20Not applicableCanada
Levetiracetamtablet, film coated250 mg/1oralAmerican Health Packaging2014-12-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralLupin Pharmaceuticals, Inc.2009-01-01Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralPrinston Pharmaceutical Inc.2012-09-11Not applicableUs
Levetiracetamsolution100 mg/mLoralSandoz Inc.2009-01-15Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralLUPIN LIMITED2009-01-15Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralLupin Pharmaceuticals, Inc.2009-01-01Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralMylan Pharmaceuticals Inc.2009-12-10Not applicableUs
Levetiracetaminjection100 mg/mLintravenousWest Ward Pharmaceuticals Corp2015-06-01Not applicableUs
Levetiracetamsolution100 mg/mLoralRoxane Laboratories, Inc2009-01-15Not applicableUs
Levetiracetamtablet250 mg/1oralREMEDYREPACK INC.2011-10-17Not applicableUs
Levetiracetamtablet, film coated, extended release750 mg/1oralSolco Healthcare US, LLC2014-05-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2010-02-01Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralRebel Distributors Corp2011-09-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralUnit Dose Services2009-01-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2008-11-04Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralNorth Star Rx Llc2009-01-15Not applicableUs
Levetiracetamtablet500 mg/1oralPhysicians Total Care, Inc.2009-10-15Not applicableUs
Levetiracetamtablet, extended release500 mg/1oralPar Pharmaceutical Inc.2011-09-13Not applicableUs
Levetiracetaminjection100 mg/mLintravenousHospira, Inc.2012-04-06Not applicableUs
Levetiracetaminjection, solution100 mg/mLintravenousNexus Pharmaceuticals Inc2010-06-03Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralLucid Pharma Llc2014-11-06Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralCamber Pharmaceuticals2012-01-09Not applicableUs
Levetiracetamsolution100 mg/mLoralMorton Grove Pharmaceuticals, Inc.2010-03-18Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2010-02-01Not applicableUs
Levetiracetamtablet1000 mg/1oralRebel Distributors Corp2009-10-15Not applicableUs
Levetiracetamsolution100 mg/mLoralCardinal Health2011-11-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralRebel Distributors Corp2011-09-01Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralbryant ranch prepack2009-01-01Not applicableUs
Levetiracetamsolution100 mg/mLoralNorth Star Rx Llc2009-01-15Not applicableUs
Levetiracetamtablet1000 mg/1oralPhysicians Total Care, Inc.2009-10-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-01-23Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralREMEDYREPACK INC.2015-11-12Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralHetero Drugs Ltd.,2010-10-08Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralCamber Pharmaceuticals2012-01-09Not applicableUs
Levetiracetamtablet, film coated, extended release500 mg/1oralApotex Corp.2011-09-12Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralAmneal Pharmaceuticals of New York, LLC2013-02-28Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralAmerican Health Packaging2010-12-29Not applicableUs
Levetiracetamsolution100 mg/mLoralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2011-11-01Not applicableUs
Levetiracetamtablet, extended release750 mg/1oralBlue Point Laboratories2014-02-13Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralPrinston Pharmaceutical Inc.2012-09-11Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralHetero Drugs Ltd.,2010-10-08Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralDispensing Solutions, Inc.2009-01-15Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralLUPIN LIMITED2009-01-01Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralMylan Pharmaceuticals Inc.2008-11-04Not applicableUs
Levetiracetamsolution100 mg/mLoralPharmaceutical Associates, Inc.2009-02-11Not applicableUs
Levetiracetamtablet500 mg/1oralREMEDYREPACK INC.2011-09-21Not applicableUs
Levetiracetamtablet, film coated, extended release500 mg/1oralSolco Healthcare US, LLC2014-05-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2010-02-01Not applicableUs
Levetiracetamtablet750 mg/1oralMajor Pharmaceuticals2013-08-02Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralUnit Dose Services2009-01-01Not applicableUs
Levetiracetamtablet, film coated, extended release750 mg/1oralQualitest Pharmaceuticals2012-07-20Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralNorth Star Rx Llc2009-01-15Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralTrigen Laboratories, Inc.2012-03-31Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralLucid Pharma Llc2014-11-06Not applicableUs
Levetiracetamsolution100 mg/mLoralTris Pharma Inc2012-10-19Not applicableUs
Levetiracetamtablet500 mg/1oralRebel Distributors Corp2009-10-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralCardinal Health2011-09-26Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralKaralex Pharma LLC2011-09-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralbryant ranch prepack2009-01-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2012-01-23Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralREMEDYREPACK INC.2015-10-09Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralHetero Drugs Ltd.,2010-10-08Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralAmneal Pharmaceuticals of New York, LLC2013-02-28Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralAmerican Health Packaging2012-04-02Not applicableUs
Levetiracetamtablet, extended release500 mg/1oralBlue Point Laboratories2014-02-13Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralPrinston Pharmaceutical Inc.2012-09-11Not applicableUs
Levetiracetamtablet, extended release750 mg/1oralLupin Pharmaceuticals, Inc.2011-09-12Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralLUPIN LIMITED2009-01-01Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralREMEDYREPACK INC.2016-01-12Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralLupin Pharmaceuticals, Inc.2009-01-01Not applicableUs
Levetiracetamsolution100 mg/mLoralSilarx Pharmaceuticals, Inc.2009-04-03Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralMylan Pharmaceuticals Inc.2008-11-04Not applicableUs
Levetiracetamsolution100 mg/mLoralPharmaceutical Associates, Inc.2015-06-04Not applicableUs
Levetiracetamtablet250 mg/1oralREMEDYREPACK INC.2011-12-07Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralSecan Pharmaceuticals, Inc.2015-12-18Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralTaro Pharmaceuticals U.S.A., Inc.2010-02-01Not applicableUs
Levetiracetamtablet500 mg/1oralMajor Pharmaceuticals2009-07-31Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralUnit Dose Services2009-01-01Not applicableUs
Levetiracetamtablet, film coated, extended release500 mg/1oralQualitest Pharmaceuticals2012-07-20Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralNorth Star Rx Llc2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Levetiracetamtablet, extended release750 mg/1oralTorrent Pharmaceuticals Limited2012-05-29Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralLucid Pharma Llc2014-11-06Not applicableUs
Levetiracetaminjection, solution, concentrate500 mg/5mLintravenousSagent Pharmaceuticals2013-11-01Not applicableUs
Levetiracetamsolution100 mg/mLoralAtlantic Biologicals Corps2009-01-16Not applicableUs
Levetiracetamtablet1000 mg/1oralDr. Reddy's Laboratories Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralKaralex Pharma LLC2011-09-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralbryant ranch prepack2009-01-01Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralAidarex Pharmaceuticals LLC2009-01-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralREMEDYREPACK INC.2015-07-03Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralAurobindo Pharma Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralAmneal Pharmaceuticals of New York, LLC2013-02-28Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralAmerican Health Packaging2010-01-28Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralMethapharm, Inc.2010-10-18Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralPrinston Pharmaceutical Inc.2012-09-11Not applicableUs
Levetiracetamtablet, extended release500 mg/1oralLupin Pharmaceuticals, Inc.2011-09-12Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralLUPIN LIMITED2009-01-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralCardinal Health2012-08-29Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralREMEDYREPACK INC.2016-03-14Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralSecan Pharmaceuticals, Inc.2015-12-18Not applicableUs
Levetiracetamsolution100 mg/mLoralTaro Pharmaceuticals U.S.A., Inc.2009-02-10Not applicableUs
Levetiracetamtablet250 mg/1oralMajor Pharmaceuticals2013-08-02Not applicableUs
Levetiracetamsolution100 mg/mLoralHi Tech Pharmacal Co., Inc.2012-02-28Not applicableUs
Levetiracetamsolution100 mg/mLoralQualitest Pharmaceuticals2012-04-11Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralNorth Star Rx Llc2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralState of Florida DOH Central Pharmacy2013-09-01Not applicableUs
Levetiracetamtablet, extended release500 mg/1oralTorrent Pharmaceuticals Limited2012-05-29Not applicableUs
Levetiracetamsolution100 mg/mLoralBreckenridge Pharmaceutical, Inc.2013-11-19Not applicableUs
Levetiracetamsolution100 mg/mLoralLLC Federal Solutions2013-09-24Not applicableUs
Levetiracetamsolution100 mg/5mLoralGolden State Medical Supply, Inc.2009-02-10Not applicableUs
Levetiracetamsolution100 mg/mLoralAtlantic Biologicals Corps2009-10-27Not applicableUs
Levetiracetamtablet750 mg/1oralDr. Reddy's Laboratories Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralKaralex Pharma LLC2011-09-01Not applicableUs
Levetiracetaminjection, solution100 mg/mLintravenousFresenius Kabi USA, LLC2010-06-03Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralAidarex Pharmaceuticals LLC2009-01-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralREMEDYREPACK INC.2015-06-19Not applicableUs
Levetiracetamsolution100 mg/mLoralAurobindo Pharma Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralAmneal Pharmaceuticals of New York, LLC2013-02-28Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralAmerican Health Packaging2010-01-28Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralMethapharm, Inc.2010-10-18Not applicableUs
Levetiracetamtablet750 mg/1oralExelan Pharmaceuticals, Inc.2009-01-15Not applicableUs
Levetiracetamsolution100 mg/mLoralLupin Pharmaceuticals, Inc.2013-01-25Not applicableUs
Levetiracetamtablet, extended release750 mg/1oralLUPIN LIMITED2011-09-12Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralREMEDYREPACK INC.2016-01-07Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralCardinal Health2012-08-29Not applicableUs
Levetiracetamsolution100 mg/mLoralCardinal Health2015-06-04Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralAjanta Pharma Limited2015-08-10Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralMylan Pharmaceuticals Inc.2008-11-04Not applicableUs
Levetiracetamsolution100 mg/mLoralPharmaceutical Associates, Inc.2015-06-04Not applicableUs
Levetiracetamtablet500 mg/1oralREMEDYREPACK INC.2011-10-12Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralSecan Pharmaceuticals, Inc.2015-12-18Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralMylan Institutional Inc.2010-03-24Not applicableUs
Levetiracetamtablet1000 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-01-15Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralAv Pak2009-03-20Not applicableUs
Levetiracetamtablet, film coated, extended release750 mg/1oralActavis Pharma, Inc.2011-09-12Not applicableUs
Levetiracetamtablet750 mg/1oralSTAT Rx USA LLC2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Levetiracetamtablet1000 mg/1oralTorrent Pharmaceuticals Limited2009-01-15Not applicableUs
Levetiracetamtablet1000 mg/1oralBreckenridge Pharmaceutical, Inc.2011-11-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralREMEDYREPACK INC.2013-05-06Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralClinical Solutions Wholesale2009-01-15Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralAccord Healthcare Inc.2011-03-14Not applicableUs
Levetiracetamtablet500 mg/1oralDr. Reddy's Laboratories Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralKaralex Pharma LLC2011-09-01Not applicableUs
Levetiracetaminjection100 mg/mLintravenousSun Pharmaceutical Industries Limited2010-06-17Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralAidarex Pharmaceuticals LLC2009-01-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralREMEDYREPACK INC.2015-02-26Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralAurobindo Pharma Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralTYA Pharmaceuticals2009-01-01Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralBlue Point Laboratories2014-02-24Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralMethapharm, Inc.2010-10-18Not applicableUs
Levetiracetamtablet500 mg/1oralExelan Pharmaceuticals, Inc.2009-01-15Not applicableUs
Levetiracetamsolution100 mg/mLoralLupin Pharmaceuticals, Inc.2014-11-01Not applicableUs
Levetiracetamtablet, extended release500 mg/1oralLUPIN LIMITED2011-09-12Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralCardinal Health2009-11-192015-12-29Us
Levetiracetamtablet, film coated1000 mg/1oralSolco Healthcare US, LLC2012-09-11Not applicableUs
Levetiracetamsolution100 mg/mLoralAtlantic Biologicals Corps2012-02-28Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralAjanta Pharma Limited2015-08-10Not applicableUs
Levetiracetamtablet, film coated, extended release500 mg/1oralActavis Elizabeth LLC2011-09-12Not applicableUs
Levetiracetamtablet, film coated, extended release750 mg/1oralTeva Pharmaceuticals USA Inc2011-09-14Not applicableUs
Levetiracetamtablet, film coated, extended release500 mg/1oralActavis Pharma, Inc.2011-09-12Not applicableUs
Levetiracetamtablet500 mg/1oralSTAT Rx USA LLC2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levetiracetamtablet750 mg/1oralTorrent Pharmaceuticals Limited2009-01-15Not applicableUs
Levetiracetamtablet750 mg/1oralBreckenridge Pharmaceutical, Inc.2011-11-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralREMEDYREPACK INC.2013-03-18Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralClinical Solutions Wholesale2009-01-01Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralAccord Healthcare Inc.2011-03-14Not applicableUs
Levetiracetamtablet250 mg/1oralDr. Reddy's Laboratories Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralLotus Pharmaceutical Co., Ltd. Nantou Plant2015-03-062016-01-09Us
Levetiracetamtablet, film coated500 mg/1oralDIRECT RX2014-01-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralREMEDYREPACK INC.2015-03-03Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralAurobindo Pharma Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralBoca Pharmacal, LLC2014-09-12Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralBlue Point Laboratories2014-02-24Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralMethapharm, Inc.2010-10-18Not applicableUs
Levetiracetamtablet250 mg/1oralExelan Pharmaceuticals, Inc.2009-01-15Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralAmerican Health Packaging2014-12-15Not applicableUs
Levetiracetaminjection, solution500 mg/5mLintravenousAuro Medics Pharma Llc2016-02-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralCardinal Health2009-11-192015-12-29Us
Levetiracetamtablet, film coated750 mg/1oralSolco Healthcare US, LLC2012-09-11Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralREMEDYREPACK INC.2016-03-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralAjanta Pharma Limited2015-08-10Not applicableUs
Levetiracetamtablet, film coated, extended release750 mg/1oralActavis Elizabeth LLC2011-09-12Not applicableUs
Levetiracetamtablet, film coated, extended release500 mg/1oralTeva Pharmaceuticals USA Inc2011-09-14Not applicableUs
Levetiracetamtablet750 mg/1oralREMEDYREPACK INC.2010-11-08Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-01Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralMylan Institutional Inc.2008-11-04Not applicableUs
Levetiracetamtablet1000 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralAv Pak2009-03-20Not applicableUs
Levetiracetaminjection, solution, concentrate500 mg/5mLintravenousX Gen Pharmaceuticals, Inc.2011-08-05Not applicableUs
Levetiracetamtablet250 mg/1oralDIRECT RX2014-01-01Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralCamber Pharmaceuticals2012-01-09Not applicableUs
Levetiracetamtablet, film coated, extended release1000 mg/1oralApotex Corp.2015-02-25Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralAurobindo Pharma Limited2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralBoca Pharmacal, LLC2014-09-12Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralBlue Point Laboratories2014-02-24Not applicableUs
Levetiracetamsolution100 mg/mLoralVista Pharm, Inc2010-01-25Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralMc Kesson Contract Packaging2011-11-23Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralAmerican Health Packaging2014-12-15Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralTeva Pharmaceuticals USA Inc2009-01-152015-11-30Us
Levetiracetamtablet, film coated500 mg/1oralSolco Healthcare US, LLC2012-09-11Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralREMEDYREPACK INC.2016-02-25Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralAjanta Pharma Limited2015-08-10Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralActavis Elizabeth LLC2011-04-04Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralTeva Pharmaceuticals USA Inc2009-01-152016-02-29Us
Levetiracetamtablet, film coated, extended release750 mg/1oralSun Pharma Global FZE2013-09-09Not applicableUs
Levetiracetamtablet500 mg/1oralPd Rx Pharmaceuticals, Inc.2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralMylan Institutional Inc.2008-11-04Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2013-02-06Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralAv Pak2009-03-20Not applicableUs
Levetiracetaminjection, solution, concentrate100 mg/mLintravenousAmerican Regent, Inc.2012-02-21Not applicableUs
Levetiracetamtablet250 mg/1oralSTAT Rx USA LLC2009-01-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levetiracetamtablet500 mg/1oralTorrent Pharmaceuticals Limited2009-01-15Not applicableUs
Levetiracetamtablet500 mg/1oralBreckenridge Pharmaceutical, Inc.2011-11-01Not applicableUs
Levetiracetamtablet750 mg/1oralRebel Distributors Corp2009-10-15Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralClinical Solutions Wholesale2009-01-01Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralAccord Healthcare Inc.2011-03-14Not applicableUs
Levetiracetamtablet, film coated, extended release500 mg/1oralPhysicians Total Care, Inc.2011-11-22Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralBlue Point Laboratories2014-02-24Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralHetero Drugs Ltd.,2010-10-08Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralMc Kesson Contract Packaging2011-10-12Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralAmerican Health Packaging2014-12-15Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralTeva Pharmaceuticals USA Inc2009-01-152015-11-30Us
Levetiracetamtablet, film coated250 mg/1oralSolco Healthcare US, LLC2012-09-11Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralREMEDYREPACK INC.2016-02-12Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralLupin Pharmaceuticals, Inc.2009-01-15Not applicableUs
Levetiracetaminjection100 mg/mLintravenousWest Ward Pharmaceuticals Corp2011-10-13Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralTeva Pharmaceuticals USA Inc2009-01-15Not applicableUs
Levetiracetamtablet, film coated, extended release500 mg/1oralSun Pharma Global FZE2013-09-09Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralRebel Distributors Corp2009-01-01Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralMylan Institutional Inc.2008-11-04Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2013-02-06Not applicableUs
Levetiracetamtablet, extended release750 mg/1oralPar Pharmaceutical Inc.2011-09-13Not applicableUs
Levetiracetamsolution100 mg/mLoralActavis Mid Atlantic LLC2009-01-15Not applicableUs
Levetiracetamsolution100 mg/mLoralOrit Laboratories LLC2012-04-30Not applicableUs
Levetiracetamtablet, film coated1000 mg/1oralLucid Pharma Llc2014-11-06Not applicableUs
Levetiracetamtablet250 mg/1oralTorrent Pharmaceuticals Limited2009-01-15Not applicableUs
Levetiracetamtablet250 mg/1oralBreckenridge Pharmaceutical, Inc.2011-11-01Not applicableUs
Levetiracetamtablet250 mg/1oralRebel Distributors Corp2009-10-15Not applicableUs
Levetiracetamsolution100 mg/mLoralCardinal Health2009-09-20Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralAccord Healthcare Inc.2011-03-14Not applicableUs
Levetiracetamtablet750 mg/1oralPhysicians Total Care, Inc.2011-06-07Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralLake Eire Medical & Surgical Supply DBA Quality Care Products LLC2011-11-14Not applicableUs
Levetiracetamtablet, film coated500 mg/1oralREMEDYREPACK INC.2015-11-12Not applicableUs
Levetiracetamtablet, film coated750 mg/1oralCamber Pharmaceuticals2012-01-09Not applicableUs
Levetiracetamtablet, film coated, extended release750 mg/1oralApotex Corp.2011-09-12Not applicableUs
Levetiracetamsolution100 mg/mLoralAmneal Pharmaceuticals of New York, LLC2009-10-27Not applicableUs
Levetiracetamtablet, film coated250 mg/1oralBoca Pharmacal, LLC2014-09-12Not applicableUs
Levetiracetam Extended-releasetablet, film coated, extended release500 mg/1oralAnchen Pharmaceuticals, Inc.2011-10-04Not applicableUs
Levetiracetam Extended-releasetablet, film coated, extended release750 mg/1oralAnchen Pharmaceuticals, Inc.2011-10-04Not applicableUs
Levetiracetam Extended-releasetablet, extended release750 mg/1oralGolden State Medical Supply, Inc.2011-09-12Not applicableUs
Levetiracetam Extended-releasetablet, extended release500 mg/1oralGolden State Medical Supply, Inc.2011-09-12Not applicableUs
Levetiracetam Levetiracetamsolution100 mg/mLoralCamber Pharmaceuticals, Inc.2015-06-11Not applicableUs
Levetiractamtablet250 mg/1oralREMEDYREPACK INC.2011-11-07Not applicableUs
Roweepratablet, film coated500 mg/1oralOwp Pharmaceuticals, Inc.2016-01-11Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII44YRR34555
CAS number102767-28-2
WeightAverage: 170.212
Monoisotopic: 170.105527699
Chemical FormulaC8H14N2O2
InChI KeyHPHUVLMMVZITSG-LURJTMIESA-N
InChI
InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
IUPAC Name
(2S)-2-(2-oxopyrrolidin-1-yl)butanamide
SMILES
CC[[email protected]](N1CCCC1=O)C(N)=O
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acids and derivatives
Alternative Parents
Substituents
  • Alpha-amino acid or derivatives
  • Fatty amide
  • Pyrrolidone
  • 2-pyrrolidone
  • N-alkylpyrrolidine
  • Fatty acyl
  • Tertiary carboxylic acid amide
  • Pyrrolidine
  • Carboxamide group
  • Primary carboxylic acid amide
  • Lactam
  • Organoheterocyclic compound
  • Azacycle
  • Carbonyl group
  • Organic nitrogen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organic oxygen compound
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Pharmacology
IndicationUsed as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.
PharmacodynamicsNot Available
Mechanism of actionThe precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizures. Levetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization. Levetiracetam also displayed inhibitory properties in the kindling model in rats, another model of human complex partial seizures, both during kindling development and in the fully kindled state. The predictive value of these animal models for specific types of human epilepsy is uncertain. Levetiracetam is thought to stimulate synaptic vesicle protein 2A (SV2A), inhibiting neurotransmitter release.
Related Articles
AbsorptionRapidly and almost completely absorbed after oral administration (99%). Peak plasma concentrations occurring in about an hour following oral administration in fasted subjects.
Volume of distributionNot Available
Protein bindingVery low (<10%)
Metabolism

The major metabolic pathway of levetiracetam (24% of dose) is an enzymatic hydrolysis of the acetamide group. No CYP450 metabolism detected.

Route of eliminationSixty-six percent (66%) of the dose is renally excreted unchanged. The metabolites have no known pharmacological activity and are renally excreted. The mechanism of excretion is glomerular filtration with subsequent partial tubular reabsorption.
Half life6-8 hours
Clearance
  • 0.96 mL/min/kg
ToxicitySide effects include aggression, agitation, coma, drowsiness, reduced consciousness, slowed breathing
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.988
Blood Brain Barrier+0.9821
Caco-2 permeable-0.6114
P-glycoprotein substrateSubstrate0.5137
P-glycoprotein inhibitor INon-inhibitor0.5612
P-glycoprotein inhibitor IINon-inhibitor0.8786
Renal organic cation transporterNon-inhibitor0.7024
CYP450 2C9 substrateNon-substrate0.8801
CYP450 2D6 substrateNon-substrate0.8184
CYP450 3A4 substrateNon-substrate0.5191
CYP450 1A2 substrateNon-inhibitor0.9394
CYP450 2C9 inhibitorNon-inhibitor0.7603
CYP450 2D6 inhibitorNon-inhibitor0.9471
CYP450 2C19 inhibitorNon-inhibitor0.8459
CYP450 3A4 inhibitorNon-inhibitor0.9669
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9502
Ames testNon AMES toxic0.8783
CarcinogenicityNon-carcinogens0.9094
BiodegradationNot ready biodegradable0.9305
Rat acute toxicity2.1707 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9206
hERG inhibition (predictor II)Non-inhibitor0.8735
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tablet, extended releaseoral1000 mg/1
Tablet, extended releaseoral1500 mg/1
Tabletoral250 mg
Tabletoral500 mg
Tabletoral750 mg
Injectionintravenous10 mg/mL
Injectionintravenous100 mg/mL
Injectionintravenous15 mg/mL
Injectionintravenous5 mg/mL
Injection, solutionintravenous100 mg/mL
Injection, solutionintravenous500 mg/5mL
Injection, solution, concentrateintravenous100 mg/mL
Injection, solution, concentrateintravenous500 mg/5mL
Solutionoral100 mg/mL
Solutionoral100 mg/5mL
Tabletoral1000 mg/1
Tabletoral250 mg/1
Tabletoral500 mg/1
Tabletoral750 mg/1
Tablet, extended releaseoral500 mg/1
Tablet, extended releaseoral750 mg/1
Tablet, film coatedoral1000 mg/1
Tablet, film coatedoral250 mg/1
Tablet, film coatedoral500 mg/1
Tablet, film coatedoral750 mg/1
Tablet, film coated, extended releaseoral1000 mg/1
Tablet, film coated, extended releaseoral500 mg/1
Tablet, film coated, extended releaseoral750 mg/1
Tablet, for suspensionoral1000 mg/1
Tablet, for suspensionoral250 mg/1
Tablet, for suspensionoral500 mg/1
Tablet, for suspensionoral750 mg/1
Prices
Unit descriptionCostUnit
Keppra 500 mg/5 ml vial9.28USD ml
Keppra 1000 mg tablet9.01USD tablet
Levetiracetam 1000 mg tablet7.18USD tablet
Keppra xr 750 mg tablet6.46USD tablet
Keppra xr 500 mg tablet6.43USD tablet
Keppra 500 mg tablet5.09USD tablet
Levetiracetam 750 mg tablet4.86USD tablet
Keppra 750 mg tablet4.74USD tablet
Keppra XR 500 mg 24 Hour tablet4.47USD tablet
Keppra 250 mg tablet3.62USD tablet
Levetiracetam 500 mg tablet3.59USD tablet
Levetiracetam 250 mg tablet2.93USD tablet
Apo-Levetiracetam 750 mg Tablet1.7USD tablet
Co Levetiracetam 750 mg Tablet1.7USD tablet
Pms-Levetiracetam 750 mg Tablet1.7USD tablet
Apo-Levetiracetam 500 mg Tablet1.23USD tablet
Co Levetiracetam 500 mg Tablet1.23USD tablet
Pms-Levetiracetam 500 mg Tablet1.23USD tablet
Apo-Levetiracetam 250 mg Tablet1.01USD tablet
Co Levetiracetam 250 mg Tablet1.01USD tablet
Pms-Levetiracetam 250 mg Tablet1.01USD tablet
Keppra 100 mg/ml Solution0.95USD ml
Levetiracetam 100 mg/ml Solution0.68USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6471992 No1998-02-202018-02-20Us
US7858122 No2008-09-172028-09-17Us
US8802142 Yes2011-12-072031-12-07Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP-0.6Not Available
Predicted Properties
PropertyValueSource
Water Solubility298.0 mg/mLALOGPS
logP-0.64ALOGPS
logP-0.59ChemAxon
logS0.24ALOGPS
pKa (Strongest Acidic)16.09ChemAxon
pKa (Strongest Basic)-1.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area63.4 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity44.08 m3·mol-1ChemAxon
Polarizability17.79 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Tooru Futagawa, Jean-Pierre Canvat, Emile Cavoy, Michel Deleers, Michel Hamende, Vincent Zimmermann, “Process for the preparation of levetiracetam.” U.S. Patent US6107492, issued September, 1996.

US6107492
General ReferencesNot Available
External Links
ATC CodesN03AX14
AHFS Codes
  • 28:12.92
PDB EntriesNot Available
FDA labelDownload (52.5 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AzelastineLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Levetiracetam.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
BuprenorphineLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
EthanolLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
HydrocodoneLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Levetiracetam.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
MefloquineThe therapeutic efficacy of Levetiracetam can be decreased when used in combination with Mefloquine.
MethotrimeprazineLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MetyrosineLevetiracetam may increase the sedative activities of Metyrosine.
MianserinThe therapeutic efficacy of Levetiracetam can be decreased when used in combination with Mianserin.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
MirtazapineLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
OrlistatThe serum concentration of Levetiracetam can be decreased when it is combined with Orlistat.
OrphenadrineLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
ParaldehydeLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
ParoxetineThe risk or severity of adverse effects can be increased when Levetiracetam is combined with Paroxetine.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
PramipexoleLevetiracetam may increase the sedative activities of Pramipexole.
RopiniroleLevetiracetam may increase the sedative activities of Ropinirole.
RotigotineLevetiracetam may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Levetiracetam.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
SuvorexantLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
ThalidomideLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ZolpidemLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Food Interactions
  • Take without regard to meals. Food does not affect bioavailabilty.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Transmembrane transporter activity
Specific Function:
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).
Gene Name:
SV2A
Uniprot ID:
Q7L0J3
Molecular Weight:
82694.665 Da
References
  1. Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B: The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9861-6. Epub 2004 Jun 21. [PubMed:15210974 ]
  2. Stahl SM: Psychopharmacology of anticonvulsants: levetiracetam as a synaptic vesicle protein modulator. J Clin Psychiatry. 2004 Sep;65(9):1162-3. [PubMed:15367040 ]
  3. Lambeng N, Grossmann M, Chatelain P, Fuks B: Solubilization and immunopurification of rat brain synaptic vesicle protein 2A with maintained binding properties. Neurosci Lett. 2006 May 1;398(1-2):107-12. Epub 2006 Jan 24. [PubMed:16434140 ]
  4. Gillard M, Chatelain P, Fuks B: Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein. Eur J Pharmacol. 2006 Apr 24;536(1-2):102-8. Epub 2006 Mar 10. [PubMed:16556440 ]
  5. Newton HB, Dalton J, Goldlust S, Pearl D: Retrospective analysis of the efficacy and tolerability of levetiracetam in patients with metastatic brain tumors. J Neurooncol. 2007 Sep;84(3):293-6. Epub 2007 Apr 13. [PubMed:17431542 ]
  6. Johannessen Landmark C: Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs. 2008;22(1):27-47. [PubMed:18072813 ]
  7. De Smedt T, Raedt R, Vonck K, Boon P: Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data. CNS Drug Rev. 2007 Spring;13(1):43-56. [PubMed:17461889 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-...
Gene Name:
CACNA1B
Uniprot ID:
Q00975
Molecular Weight:
262493.84 Da
References
  1. De Smedt T, Raedt R, Vonck K, Boon P: Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data. CNS Drug Rev. 2007 Spring;13(1):43-56. [PubMed:17461889 ]
  2. Lukyanetz EA, Shkryl VM, Kostyuk PG: Selective blockade of N-type calcium channels by levetiracetam. Epilepsia. 2002 Jan;43(1):9-18. [PubMed:11879381 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. [PubMed:17045309 ]
  2. Luna-Tortos C, Fedrowitz M, Loscher W: Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. doi: 10.1016/j.neuropharm.2008.08.032. Epub 2008 Sep 11. [PubMed:18824002 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. [PubMed:17045309 ]
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Drug created on June 13, 2005 07:24 / Updated on June 26, 2016 03:07