You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on DrugBank.
Identification
NameTemafloxacin
Accession NumberDB01405
TypeSmall Molecule
GroupsWithdrawn
Description

Temafloxacin is a fluoroquinolone antibiotic drug which was withdrawn from sale in the U.S. shortly after its approval in 1992 because of serious adverse reactions resulting in three deaths. [Wikipedia]

Structure
Thumb
Synonyms
SynonymLanguageCode
TemafloxacinaSpanishNot Available
TemafloxacineFrenchNot Available
TemafloxacinumLatinNot Available
Salts
Name/CAS Structure Properties
Temafloxacin hydrochloride
Thumb
  • InChI Key: QKDHBVNJCZBTMR-UHFFFAOYNA-N
  • Monoisotopic Mass: 417.130026072
  • Average Mass: 417.3811
DBSALT000794
Brand names
NameCompany
OmnifloxNot Available
Brand mixturesNot Available
Categories
CAS number108319-06-8
WeightAverage: 417.3811
Monoisotopic: 417.130026072
Chemical FormulaC21H18F3N3O3
InChI KeyQKDHBVNJCZBTMR-UHFFFAOYSA-N
InChI
InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
IUPAC Name
1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
SMILES
CC1CN(CCN1)C1=C(F)C=C2C(=O)C(=CN(C2=C1)C1=C(F)C=C(F)C=C1)C(O)=O
Mass SpecNot Available
Taxonomy
KingdomOrganic Compounds
SuperclassHeterocyclic Compounds
ClassQuinolines and Derivatives
SubclassPhenylquinolines
Direct parentPhenylquinolines
Alternative parentsQuinoline Carboxylic Acids; Fluoroquinolones; Hydroquinolones; Hydroquinolines; Pyridinecarboxylic Acids; Fluorobenzenes; Aryl Fluorides; Diazinanes; Piperazines; Tertiary Amines; Enolates; Polyamines; Dialkylamines; Carboxylic Acids; Organofluorides
Substituentsquinoline-3-carboxylic acid; fluoroquinolone; dihydroquinolone; dihydroquinoline; pyridine carboxylic acid; pyridine carboxylic acid or derivative; fluorobenzene; benzene; 1,4-diazinane; pyridine; aryl halide; aryl fluoride; piperazine; tertiary amine; polyamine; secondary amine; enolate; secondary aliphatic amine; carboxylic acid derivative; carboxylic acid; organonitrogen compound; amine; organohalogen; organofluoride
Classification descriptionThis compound belongs to the phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group.
Pharmacology
IndicationFor the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.
PharmacodynamicsTemafloxacin (marketed by Abbott Laboratories as Omniflox), is a fluoroquinolone antibiotic drug which was withdrawn from sale in the U.S. shortly after its approval in 1992 because of serious adverse reactions resulting in three deaths. Flouroquinolones such as lomefloxacin possess excellent activity against gram-negative aerobic bacteria such as E.coli and Neisseria gonorrhoea as well as gram-positive bacteria including S. pneumoniae and Staphylococcus aureus. They also posses effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter.
Mechanism of actionThe bactericidal action of temafloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.
AbsorptionStudies in healthy volunteers indicate that the average bioavailability of temafloxacin exceeds 90%, with little intersubject variability.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic.

Route of eliminationNot Available
Half lifeApproximately 8 hours in patients with normal renal function.
ClearanceNot Available
ToxicitySevere adverse reactions, including allergic reactions and hemolytic anemia, developed in about fifty patients during the first four months of its use, leading to three patient deaths
Affected organisms
  • Enteric bacteria and other eubacteria
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
Property Value Probability
Human Intestinal Absorption + 0.9914
Blood Brain Barrier - 0.9863
Caco-2 permeable - 0.7526
P-glycoprotein substrate Substrate 0.8741
P-glycoprotein inhibitor I Non-inhibitor 0.8985
P-glycoprotein inhibitor II Non-inhibitor 0.9081
Renal organic cation transporter Non-inhibitor 0.7441
CYP450 2C9 substrate Non-substrate 0.8128
CYP450 2D6 substrate Non-substrate 0.9072
CYP450 3A4 substrate Non-substrate 0.7309
CYP450 1A2 substrate Non-inhibitor 0.8664
CYP450 2C9 substrate Non-inhibitor 0.9304
CYP450 2D6 substrate Non-inhibitor 0.9413
CYP450 2C19 substrate Non-inhibitor 0.9048
CYP450 3A4 substrate Non-inhibitor 0.8858
CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.6993
Ames test AMES toxic 0.9067
Carcinogenicity Non-carcinogens 0.8318
Biodegradation Not ready biodegradable 1.0
Rat acute toxicity 2.0973 LD50, mol/kg Not applicable
hERG inhibition (predictor I) Weak inhibitor 0.8332
hERG inhibition (predictor II) Non-inhibitor 0.7289
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
Statesolid
Experimental Properties
PropertyValueSource
logP-0.20BIOBYTE (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.0144ALOGPS
logP0.94ALOGPS
logP1.08ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)5.6ChemAxon
pKa (Strongest Basic)8.76ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area72.88 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity104.53 m3·mol-1ChemAxon
Polarizability39.7 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
SpectraNot Available
References
Synthesis ReferenceNot Available
General ReferenceNot Available
External Links
ResourceLink
KEGG DrugD02469
PubChem Compound60021
PubChem Substance46508032
ChemSpider54143
WikipediaTemafloxacin
ATC CodesJ01MA05
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Interactions
Drug Interactions
Drug
CalciumFormation of non-absorbable complexes
Iron DextranFormation of non-absorbable complexes
MagnesiumFormation of non-absorbable complexes
Food InteractionsNot Available

Targets

1. DNA gyrase subunit A

Kind: protein

Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
DNA gyrase subunit A P43700 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Frank KE, Devasthale PV, Gentry EJ, Ravikumar VT, Keschavarz-Shokri A, Mitscher LA, Nilius A, Shen LL, Shawar R, Baker WR: A simple, inexpensive apparatus for performance of preparative scale solution phase multiple parallel synthesis of drug analogs. II. Biological evaluation of a retrospective library of quinolone antiinfective agents. Comb Chem High Throughput Screen. 1998 Jun;1(2):89-99. Pubmed
  4. Nakanishi N, Yoshida S, Wakebe H, Inoue M, Yamaguchi T, Mitsuhashi S: Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus. Antimicrob Agents Chemother. 1991 Dec;35(12):2562-7. Pubmed
  5. Nakanishi N, Yoshida S, Wakebe H, Inoue M, Mitsuhashi S: Mechanisms of clinical resistance to fluoroquinolones in Enterococcus faecalis. Antimicrob Agents Chemother. 1991 Jun;35(6):1053-9. Pubmed
  6. Appelbaum PC: Mechanisms and frequency of resistance to temafloxacin. Am J Med. 1991 Dec 30;91(6A):27S-30S. Pubmed

2. DNA topoisomerase 4 subunit A

Kind: protein

Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Pharmacological action: yes

Actions: inhibitor

Components

Name UniProt ID Details
DNA topoisomerase 4 subunit A P43702 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Nakanishi N, Yoshida S, Wakebe H, Inoue M, Yamaguchi T, Mitsuhashi S: Mechanisms of clinical resistance to fluoroquinolones in Staphylococcus aureus. Antimicrob Agents Chemother. 1991 Dec;35(12):2562-7. Pubmed
  4. Nakanishi N, Yoshida S, Wakebe H, Inoue M, Mitsuhashi S: Mechanisms of clinical resistance to fluoroquinolones in Enterococcus faecalis. Antimicrob Agents Chemother. 1991 Jun;35(6):1053-9. Pubmed
  5. Appelbaum PC: Mechanisms and frequency of resistance to temafloxacin. Am J Med. 1991 Dec 30;91(6A):27S-30S. Pubmed

Enzymes

1. Cytochrome P450 1A2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 1A2 P05177 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Comments
comments powered by Disqus
Drug created on July 13, 2007 14:27 / Updated on September 16, 2013 17:14