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Identification
NameEstriol
Accession NumberDB04573  (EXPT01361, DB05375)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionA hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
Structure
Thumb
Synonyms
(16alpha,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol
(16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol
1,3,5(10)-Estratriene-3,16-alpha,17beta-triol
16-alpha-Hydroxyestradiol
16alpha-hydroxyestradiol
16α-hydroxyestradiol
3,16alpha,17beta-Trihydroxy-delta(1,3,5)-estratriene
Deuslon-a
Estriel
Estriol
Oestriol
Trihydroxyestrin
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AacifemineOrganon
ColpoestriolTemis-Lostalo
OvestinMerck Sharp & Dohme
Synapause EOrganon
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Estriol tripropionate
Thumb
  • InChI Key: ONMZMZJEZHMWQL-REUUDLSRSA-N
  • Monoisotopic Mass: 456.251188884
  • Average Mass: 456.5711
DBSALT000069
Categories
UNIIFB33469R8E
CAS number50-27-1
WeightAverage: 288.3814
Monoisotopic: 288.172544634
Chemical FormulaC18H24O3
InChI KeyInChIKey=PROQIPRRNZUXQM-ZXXIGWHRSA-N
InChI
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
IUPAC Name
(1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-triene-5,13,14-triol
SMILES
[H][C@@]12C[C@@H](O)[[email protected]](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassEstrane steroids
Direct ParentEstrogens and derivatives
Alternative Parents
Substituents
  • Estrogen-skeleton
  • 17-hydroxysteroid
  • 16-hydroxysteroid
  • 16-alpha-hydroxysteroid
  • Hydroxysteroid
  • 3-hydroxysteroid
  • Phenanthrene
  • Tetralin
  • Benzenoid
  • Cyclic alcohol
  • Secondary alcohol
  • Polyol
  • 1,2-diol
  • Hydrocarbon derivative
  • Organooxygen compound
  • Alcohol
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationUsed as a test to determine the general health of an unborn fetus.
PharmacodynamicsEstriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
Mechanism of actionEstriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child. The drug interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estriol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism
SubstrateEnzymesProduct
Estriol
Not Available
Estriol-16-GlucuronideDetails
Estriol
Not Available
Estriol-17-glucuronideDetails
Estriol
Not Available
Estriol-3-glucuronideDetails
Estriol
Not Available
16-alpha,17-beta-estriol 17-beta-D-glucuronideDetails
Estriol
Not Available
Estriol 3-sulfate 16-glucuronideDetails
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityORAL (LD50): Acute: >2000 mg/kg [Rat].
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9966
Blood Brain Barrier+0.7057
Caco-2 permeable+0.7591
P-glycoprotein substrateSubstrate0.7862
P-glycoprotein inhibitor INon-inhibitor0.9208
P-glycoprotein inhibitor IINon-inhibitor0.9805
Renal organic cation transporterNon-inhibitor0.8619
CYP450 2C9 substrateNon-substrate0.7536
CYP450 2D6 substrateNon-substrate0.7993
CYP450 3A4 substrateSubstrate0.6892
CYP450 1A2 substrateNon-inhibitor0.6618
CYP450 2C9 inhibitorNon-inhibitor0.9399
CYP450 2D6 inhibitorNon-inhibitor0.9619
CYP450 2C19 inhibitorNon-inhibitor0.7086
CYP450 3A4 inhibitorNon-inhibitor0.8932
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9152
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9147
BiodegradationNot ready biodegradable0.9811
Rat acute toxicity1.9758 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.948
hERG inhibition (predictor II)Inhibitor0.7684
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point82-86Organon Laboratories Limited, England; British Patent 879,014; October 4, 1961.
logP2.45HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.119 mg/mLALOGPS
logP2.54ALOGPS
logP2.67ChemAxon
logS-3.4ALOGPS
pKa (Strongest Acidic)10.33ChemAxon
pKa (Strongest Basic)-3.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area60.69 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity81.27 m3·mol-1ChemAxon
Polarizability33.07 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (2.96 KB)
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MS (3 TMS)splash10-005a-1983000000-2f46d0d29b48132f7670View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0a4i-5900000000-2102cb581ac98fea87b0View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0a4i-1900000000-1fab12be883127f80c67View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0a4i-5900000000-2102cb581ac98fea87b0View in MoNA
LC-MS/MSLC-MS/MS Spectrum - EI-B (JEOL JMS-01-SG-2) , Positivesplash10-000i-4970000000-1aa2bbf3f32fd687c37dView in MoNA
MSMass Spectrum (Electron Ionization)splash10-000i-3950000000-c2f0781bc5056d66aaf5View in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
References
Synthesis Reference

James V. Freeman, Gary M. Johnson, “Synthesis of 6.alpha.-functionalized estriol haptens and protein conjugates thereof.” U.S. Patent US5902888, issued June, 1973.

US5902888
General References
  1. Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR: Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003 Dec 1;171(11):6267-74. [PubMed:14634144 ]
  2. Trimesta [Link]
External Links
ATC CodesG03CC06G03CA04
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (75.9 KB)
Interactions
Drug Interactions
Drug
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Estriol.
AbciximabEstriol may decrease the anticoagulant activities of Abciximab.
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Estriol.
AcenocoumarolEstriol may decrease the anticoagulant activities of Acenocoumarol.
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Estriol.
AcetaminophenThe serum concentration of Estriol can be increased when it is combined with Acetaminophen.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Estriol.
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Estriol.
AfatinibThe serum concentration of Estriol can be increased when it is combined with Afatinib.
AlbendazoleThe serum concentration of Estriol can be increased when it is combined with Albendazole.
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Estriol.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Estriol.
AldosteroneThe serum concentration of Estriol can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Estriol can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Estriol can be increased when it is combined with Alfentanil.
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Estriol.
AmantadineThe serum concentration of Estriol can be increased when it is combined with Amantadine.
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Estriol.
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Estriol.
Aminohippuric acidThe serum concentration of Estriol can be increased when it is combined with Aminohippuric acid.
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Estriol.
AmiodaroneThe serum concentration of Estriol can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Estriol.
AmitriptylineThe serum concentration of Estriol can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Estriol can be increased when it is combined with Amlodipine.
AmprenavirThe serum concentration of Estriol can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Estriol can be increased when it is combined with Amsacrine.
AnastrozoleThe therapeutic efficacy of Anastrozole can be decreased when used in combination with Estriol.
AncrodEstriol may decrease the anticoagulant activities of Ancrod.
Anthrax immune globulin humanEstriol may increase the thrombogenic activities of Anthrax immune globulin human.
Antithrombin III humanEstriol may decrease the anticoagulant activities of Antithrombin III human.
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Estriol.
ArdeparinEstriol may decrease the anticoagulant activities of Ardeparin.
ArgatrobanEstriol may decrease the anticoagulant activities of Argatroban.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Estriol.
AstemizoleThe serum concentration of Estriol can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Estriol.
AtazanavirThe serum concentration of Estriol can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Estriol.
AtenololThe serum concentration of Estriol can be increased when it is combined with Atenolol.
AtorvastatinThe serum concentration of Estriol can be increased when it is combined with Atorvastatin.
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Estriol.
AzelastineThe serum concentration of Estriol can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Estriol can be increased when it is combined with Azithromycin.
BecaplerminEstriol may decrease the anticoagulant activities of Becaplermin.
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Estriol.
BenzocaineThe serum concentration of Estriol can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Estriol can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Estriol.
BiperidenThe serum concentration of Estriol can be increased when it is combined with Biperiden.
BivalirudinEstriol may decrease the anticoagulant activities of Bivalirudin.
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Estriol.
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Estriol.
BosutinibThe serum concentration of Estriol can be increased when it is combined with Bosutinib.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Estriol.
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Estriol.
BromocriptineThe serum concentration of Estriol can be increased when it is combined with Bromocriptine.
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Estriol.
BuprenorphineThe serum concentration of Estriol can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Estriol can be increased when it is combined with Buspirone.
C1 Esterase Inhibitor (Human)Estriol may increase the thrombogenic activities of C1 Esterase Inhibitor (Human).
C1 Esterase Inhibitor (Recombinant)Estriol may increase the thrombogenic activities of C1 Esterase Inhibitor (Recombinant).
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Estriol.
CabazitaxelThe serum concentration of Estriol can be increased when it is combined with Cabazitaxel.
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Estriol.
CaffeineThe serum concentration of Estriol can be increased when it is combined with Caffeine.
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Estriol.
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Estriol.
CanagliflozinThe serum concentration of Estriol can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Estriol can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Estriol can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Estriol can be decreased when it is combined with Carbamazepine.
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Estriol.
CarvedilolThe serum concentration of Estriol can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Estriol can be increased when it is combined with Caspofungin.
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Estriol.
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Estriol.
CertoparinEstriol may decrease the anticoagulant activities of Certoparin.
Chenodeoxycholic acidThe therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Estriol.
ChloroquineThe serum concentration of Estriol can be increased when it is combined with Chloroquine.
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Estriol.
ChlorpromazineThe serum concentration of Estriol can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Estriol can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Estriol can be increased when it is combined with Chlorprothixene.
CholesterolThe serum concentration of Estriol can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Estriol can be decreased when it is combined with Cholic Acid.
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Estriol.
CilazaprilThe serum concentration of Estriol can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Estriol can be decreased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Estriol.
CiprofloxacinThe serum concentration of Estriol can be increased when it is combined with Ciprofloxacin.
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Estriol.
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Estriol.
CitalopramThe serum concentration of Estriol can be increased when it is combined with Citalopram.
Citric AcidEstriol may decrease the anticoagulant activities of Citric Acid.
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Estriol.
ClarithromycinThe serum concentration of Estriol can be increased when it is combined with Clarithromycin.
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Estriol.
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Estriol.
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Estriol.
ClofazimineThe serum concentration of Estriol can be increased when it is combined with Clofazimine.
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Estriol.
ClomipramineThe serum concentration of Estriol can be increased when it is combined with Clomipramine.
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Estriol.
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Estriol.
ClotrimazoleThe serum concentration of Estriol can be decreased when it is combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Estriol.
CobicistatThe serum concentration of Estriol can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Estriol.
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Estriol.
ColchicineThe serum concentration of Estriol can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Estriol can be increased when it is combined with Colforsin.
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Estriol.
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Estriol.
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Estriol.
CrizotinibThe serum concentration of Estriol can be increased when it is combined with Crizotinib.
CyclophosphamideThe serum concentration of Estriol can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Estriol can be decreased when it is combined with Cyclosporine.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Estriol.
DabrafenibThe serum concentration of Dabrafenib can be decreased when it is combined with Estriol.
DaclatasvirThe serum concentration of Estriol can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Estriol.
DactinomycinThe serum concentration of Estriol can be increased when it is combined with Dactinomycin.
DalteparinEstriol may decrease the anticoagulant activities of Dalteparin.
DanaparoidEstriol may decrease the anticoagulant activities of Danaparoid.
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Estriol.
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Estriol.
DasatinibThe serum concentration of Estriol can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Estriol can be decreased when it is combined with Daunorubicin.
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Estriol.
DehydroepiandrosteroneThe risk or severity of adverse effects can be increased when Dehydroepiandrosterone is combined with Estriol.
DehydroepiandrosteroneThe serum concentration of Dehydroepiandrosterone can be increased when it is combined with Estriol.
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Estriol.
DesipramineThe serum concentration of Estriol can be increased when it is combined with Desipramine.
DesirudinEstriol may decrease the anticoagulant activities of Desirudin.
DesloratadineThe serum concentration of Estriol can be increased when it is combined with Desloratadine.
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Estriol.
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Estriol.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Estriol.
DexamethasoneThe serum concentration of Estriol can be decreased when it is combined with Dexamethasone.
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Estriol.
DextranEstriol may decrease the anticoagulant activities of Dextran.
Dextran 40Estriol may decrease the anticoagulant activities of Dextran 40.
Dextran 70Estriol may decrease the anticoagulant activities of Dextran 70.
Dextran 75Estriol may decrease the anticoagulant activities of Dextran 75.
DextromethorphanThe serum concentration of Estriol can be increased when it is combined with Dextromethorphan.
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Estriol.
DiclofenacThe serum concentration of Estriol can be increased when it is combined with Diclofenac.
DicoumarolEstriol may decrease the anticoagulant activities of Dicoumarol.
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Estriol.
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Estriol.
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Estriol.
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Estriol.
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Estriol.
DigoxinThe serum concentration of Estriol can be decreased when it is combined with Digoxin.
DihydroergotamineThe serum concentration of Estriol can be increased when it is combined with Dihydroergotamine.
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Estriol.
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Estriol.
DiltiazemThe serum concentration of Estriol can be increased when it is combined with Diltiazem.
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Estriol.
DipyridamoleThe serum concentration of Estriol can be increased when it is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Estriol.
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Estriol.
DoxazosinThe serum concentration of Estriol can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Estriol can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Estriol can be decreased when it is combined with Doxorubicin.
DronabinolThe serum concentration of Estriol can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Estriol can be increased when it is combined with Dronedarone.
DyphyllineThe serum concentration of Dyphylline can be increased when it is combined with Estriol.
Edetic AcidEstriol may decrease the anticoagulant activities of Edetic Acid.
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Estriol.
ElbasvirThe serum concentration of Estriol can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Estriol.
EnalaprilThe serum concentration of Estriol can be increased when it is combined with Enalapril.
EnoxaparinEstriol may decrease the anticoagulant activities of Enoxaparin.
EnzalutamideThe serum concentration of Estriol can be increased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Estriol.
EquileninThe serum concentration of Equilenin can be increased when it is combined with Estriol.
EquilinThe serum concentration of Equilin can be increased when it is combined with Estriol.
ErgonovineThe serum concentration of Estriol can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Estriol can be increased when it is combined with Ergotamine.
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Estriol.
ErythromycinThe serum concentration of Estriol can be decreased when it is combined with Erythromycin.
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Estriol.
EstramustineThe serum concentration of Estriol can be increased when it is combined with Estramustine.
EstroneThe serum concentration of Estrone can be increased when it is combined with Estriol.
EstroneThe serum concentration of Estriol can be decreased when it is combined with Estrone.
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Estriol.
Ethyl biscoumacetateEstriol may decrease the anticoagulant activities of Ethyl biscoumacetate.
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Estriol.
EtoposideThe serum concentration of Estriol can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Estriol can be increased when it is combined with Etravirine.
ExemestaneThe therapeutic efficacy of Exemestane can be decreased when used in combination with Estriol.
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Estriol.
FelodipineThe serum concentration of Estriol can be increased when it is combined with Felodipine.
FentanylThe serum concentration of Estriol can be increased when it is combined with Fentanyl.
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Estriol.
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Estriol.
FexofenadineThe serum concentration of Estriol can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Estriol.
FidaxomicinThe serum concentration of Estriol can be increased when it is combined with Fidaxomicin.
FluconazoleThe serum concentration of Estriol can be increased when it is combined with Fluconazole.
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Estriol.
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Estriol.
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Estriol.
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Estriol.
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Estriol.
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Estriol.
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Estriol.
FluoxetineThe serum concentration of Estriol can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Estriol can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Estriol can be increased when it is combined with Fluphenazine.
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Estriol.
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Estriol.
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Estriol.
FlurazepamThe serum concentration of Estriol can be increased when it is combined with Flurazepam.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Estriol.
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Estriol.
FluvoxamineThe serum concentration of Estriol can be increased when it is combined with Fluvoxamine.
Fondaparinux sodiumEstriol may decrease the anticoagulant activities of Fondaparinux sodium.
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Estriol.
GefitinibThe serum concentration of Estriol can be increased when it is combined with Gefitinib.
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Estriol.
GenisteinThe serum concentration of Estriol can be increased when it is combined with Genistein.
GlyburideThe serum concentration of Estriol can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Estriol can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Estriol can be increased when it is combined with Gramicidin D.
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Estriol.
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Estriol.
GrepafloxacinThe serum concentration of Estriol can be increased when it is combined with Grepafloxacin.
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Estriol.
HaloperidolThe serum concentration of Estriol can be increased when it is combined with Haloperidol.
HeparinEstriol may decrease the anticoagulant activities of Heparin.
HirulogEstriol may decrease the anticoagulant activities of Hirulog.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Estriol.
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Estriol.
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Estriol.
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Estriol.
IdelalisibThe serum concentration of Estriol can be increased when it is combined with Idelalisib.
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Estriol.
ImatinibThe serum concentration of Estriol can be increased when it is combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Estriol.
ImipramineThe serum concentration of Estriol can be increased when it is combined with Imipramine.
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Estriol.
IndinavirThe serum concentration of Estriol can be decreased when it is combined with Indinavir.
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Estriol.
IndomethacinThe serum concentration of Estriol can be increased when it is combined with Indomethacin.
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Estriol.
IsavuconazoniumThe serum concentration of Estriol can be increased when it is combined with Isavuconazonium.
ItraconazoleThe serum concentration of Estriol can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Estriol can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Estriol.
IvermectinThe serum concentration of Estriol can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Estriol can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Estriol.
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Estriol.
KetoconazoleThe serum concentration of Estriol can be increased when it is combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Estriol.
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Estriol.
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Estriol.
LansoprazoleThe serum concentration of Estriol can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Estriol can be increased when it is combined with Lapatinib.
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Estriol.
LenalidomideEstriol may increase the thrombogenic activities of Lenalidomide.
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Estriol.
LepirudinEstriol may decrease the anticoagulant activities of Lepirudin.
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Estriol.
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Estriol.
LevofloxacinThe serum concentration of Estriol can be increased when it is combined with Levofloxacin.
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Estriol.
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Estriol.
LevothyroxineThe serum concentration of Estriol can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Estriol can be increased when it is combined with Lidocaine.
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Estriol.
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Estriol.
LiothyronineThe serum concentration of Estriol can be decreased when it is combined with Liothyronine.
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Estriol.
LiotrixThe serum concentration of Estriol can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Estriol can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Estriol can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Estriol.
LoperamideThe serum concentration of Estriol can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Estriol can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Estriol can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Losartan can be decreased when it is combined with Estriol.
LosartanThe serum concentration of Estriol can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Estriol can be increased when it is combined with Lovastatin.
LumacaftorThe serum concentration of Estriol can be decreased when it is combined with Lumacaftor.
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Estriol.
MaprotilineThe serum concentration of Estriol can be increased when it is combined with Maprotiline.
MebendazoleThe serum concentration of Estriol can be increased when it is combined with Mebendazole.
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Estriol.
MefloquineThe serum concentration of Estriol can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Estriol can be increased when it is combined with Megestrol acetate.
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Estriol.
MeprobamateThe serum concentration of Estriol can be increased when it is combined with Meprobamate.
MethadoneThe serum concentration of Estriol can be increased when it is combined with Methadone.
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Estriol.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Estriol.
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Estriol.
MetoprololThe serum concentration of Estriol can be increased when it is combined with Metoprolol.
MibefradilThe serum concentration of Estriol can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Estriol can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Estriol can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Estriol can be decreased when it is combined with Mifepristone.
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Estriol.
MitomycinThe serum concentration of Estriol can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Estriol can be decreased when it is combined with Mitoxantrone.
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Estriol.
MorphineThe serum concentration of Morphine can be decreased when it is combined with Estriol.
MorphineThe serum concentration of Estriol can be increased when it is combined with Morphine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Estriol.
NadololThe serum concentration of Nadolol can be decreased when it is combined with Estriol.
NadroparinEstriol may decrease the anticoagulant activities of Nadroparin.
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Estriol.
NaltrexoneThe serum concentration of Estriol can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Estriol can be increased when it is combined with Naringenin.
NefazodoneThe serum concentration of Estriol can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Estriol can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Estriol can be increased when it is combined with Neostigmine.
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Estriol.
NicardipineThe serum concentration of Estriol can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Estriol can be decreased when it is combined with Nifedipine.
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Estriol.
NilotinibThe serum concentration of Estriol can be increased when it is combined with Nilotinib.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Estriol.
NisoldipineThe serum concentration of Estriol can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Estriol can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Estriol can be increased when it is combined with Nitrendipine.
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Estriol.
NorethisteroneThe serum concentration of Estriol can be decreased when it is combined with Norethisterone.
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Estriol.
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Estriol.
OmeprazoleThe serum concentration of Estriol can be increased when it is combined with Omeprazole.
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Estriol.
OspemifeneThe risk or severity of adverse effects can be increased when Estriol is combined with Ospemifene.
OtamixabanEstriol may decrease the anticoagulant activities of Otamixaban.
P-NitrophenolThe serum concentration of Estriol can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Estriol.
PaclitaxelThe serum concentration of Estriol can be increased when it is combined with Paclitaxel.
Palmitic AcidThe serum concentration of Estriol can be increased when it is combined with Palmitic Acid.
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Estriol.
PantoprazoleThe serum concentration of Estriol can be increased when it is combined with Pantoprazole.
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Estriol.
ParoxetineThe serum concentration of Estriol can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Estriol.
Pentosan PolysulfateEstriol may decrease the anticoagulant activities of Pentosan Polysulfate.
PerindoprilThe serum concentration of Estriol can be increased when it is combined with Perindopril.
PhenindioneEstriol may decrease the anticoagulant activities of Phenindione.
PhenobarbitalThe serum concentration of Estriol can be decreased when it is combined with Phenobarbital.
PhenprocoumonEstriol may decrease the anticoagulant activities of Phenprocoumon.
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Estriol.
PimozideThe serum concentration of Estriol can be increased when it is combined with Pimozide.
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Estriol.
Platelet Activating FactorThe serum concentration of Estriol can be decreased when it is combined with Platelet Activating Factor.
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Estriol.
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Estriol.
PonatinibThe serum concentration of Estriol can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Estriol can be increased when it is combined with Posaconazole.
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Estriol.
PravastatinThe serum concentration of Estriol can be increased when it is combined with Pravastatin.
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Estriol.
PrazosinThe serum concentration of Estriol can be increased when it is combined with Prazosin.
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Estriol.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Estriol.
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Estriol.
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Estriol.
ProbenecidThe serum concentration of Estriol can be increased when it is combined with Probenecid.
ProgesteroneThe serum concentration of Estriol can be decreased when it is combined with Progesterone.
PromethazineThe serum concentration of Estriol can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Estriol can be increased when it is combined with Propafenone.
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Estriol.
PropranololThe serum concentration of Estriol can be increased when it is combined with Propranolol.
Protein CEstriol may decrease the anticoagulant activities of Protein C.
ProtocatechualdehydeEstriol may decrease the anticoagulant activities of Protocatechualdehyde.
ProtriptylineThe serum concentration of Estriol can be increased when it is combined with Protriptyline.
QuercetinThe serum concentration of Estriol can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Estriol.
QuinacrineThe serum concentration of Estriol can be increased when it is combined with Quinacrine.
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Estriol.
QuinidineThe serum concentration of Estriol can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Quinine can be decreased when it is combined with Estriol.
QuinineThe serum concentration of Estriol can be increased when it is combined with Quinine.
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with Estriol.
RanitidineThe serum concentration of Estriol can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Estriol can be increased when it is combined with Ranolazine.
ReboxetineThe serum concentration of Estriol can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Estriol can be increased when it is combined with Regorafenib.
ReserpineThe serum concentration of Estriol can be decreased when it is combined with Reserpine.
ReviparinEstriol may decrease the anticoagulant activities of Reviparin.
RifampicinThe serum concentration of Estriol can be decreased when it is combined with Rifampicin.
RilpivirineThe serum concentration of Estriol can be increased when it is combined with Rilpivirine.
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Estriol.
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Estriol.
RitonavirThe serum concentration of Estriol can be decreased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Estriol.
RolapitantThe serum concentration of Estriol can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Estriol.
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Estriol.
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Estriol.
SaquinavirThe serum concentration of Estriol can be decreased when it is combined with Saquinavir.
ScopolamineThe serum concentration of Estriol can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Estriol can be increased when it is combined with Selegiline.
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Estriol.
SertralineThe serum concentration of Estriol can be increased when it is combined with Sertraline.
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Estriol.
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Estriol.
SimeprevirThe serum concentration of Estriol can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Estriol can be increased when it is combined with Simvastatin.
SirolimusThe serum concentration of Estriol can be decreased when it is combined with Sirolimus.
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Estriol.
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Estriol.
Somatropin recombinantThe therapeutic efficacy of Somatropin recombinant can be decreased when used in combination with Estriol.
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Estriol.
SorafenibThe serum concentration of Estriol can be increased when it is combined with Sorafenib.
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Estriol.
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Estriol.
SpironolactoneThe serum concentration of Estriol can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Estriol can be decreased when it is combined with St. John's Wort.
StaurosporineThe serum concentration of Estriol can be increased when it is combined with Staurosporine.
StreptozocinThe serum concentration of Estriol can be decreased when it is combined with Streptozocin.
SulfinpyrazoneThe serum concentration of Estriol can be increased when it is combined with Sulfinpyrazone.
SulodexideEstriol may decrease the anticoagulant activities of Sulodexide.
SumatriptanThe serum concentration of Estriol can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Estriol can be increased when it is combined with Sunitinib.
TacrineThe serum concentration of Estriol can be increased when it is combined with Tacrine.
TacrolimusThe serum concentration of Estriol can be decreased when it is combined with Tacrolimus.
TamoxifenThe serum concentration of Estriol can be decreased when it is combined with Tamoxifen.
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Estriol.
Taurocholic AcidThe serum concentration of Estriol can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Estriol.
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Estriol.
TelmisartanThe serum concentration of Estriol can be increased when it is combined with Telmisartan.
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Estriol.
TemsirolimusThe serum concentration of Estriol can be increased when it is combined with Temsirolimus.
TerazosinThe serum concentration of Estriol can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Estriol can be increased when it is combined with Terfenadine.
TesmilifeneThe serum concentration of Estriol can be decreased when it is combined with Tesmilifene.
TestosteroneThe serum concentration of Estriol can be increased when it is combined with Testosterone.
ThalidomideEstriol may increase the thrombogenic activities of Thalidomide.
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Estriol.
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Estriol.
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Estriol.
TicagrelorThe serum concentration of Estriol can be increased when it is combined with Ticagrelor.
TimololThe serum concentration of Timolol can be decreased when it is combined with Estriol.
TipranavirEstriol may increase the dermatologic adverse activities of Tipranavir.
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Estriol.
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Estriol.
TolvaptanThe serum concentration of Estriol can be increased when it is combined with Tolvaptan.
TopotecanThe serum concentration of Topotecan can be decreased when it is combined with Estriol.
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Estriol.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Estriol.
TrazodoneThe serum concentration of Estriol can be decreased when it is combined with Trazodone.
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Estriol.
TrifluoperazineThe serum concentration of Estriol can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Estriol can be increased when it is combined with Triflupromazine.
TrimethoprimThe serum concentration of Estriol can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Estriol can be increased when it is combined with Trimipramine.
TroleandomycinThe serum concentration of Estriol can be increased when it is combined with Troleandomycin.
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Estriol.
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Estriol.
Ursodeoxycholic acidThe therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Estriol.
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Estriol.
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Estriol.
VenlafaxineThe serum concentration of Estriol can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Estriol can be decreased when it is combined with Verapamil.
VinblastineThe serum concentration of Estriol can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Estriol.
VinorelbineThe serum concentration of Estriol can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Estriol.
Vitamin CThe serum concentration of Estriol can be increased when it is combined with Vitamin C.
WarfarinEstriol may decrease the anticoagulant activities of Warfarin.
XimelagatranEstriol may decrease the anticoagulant activities of Ximelagatran.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Estriol.
ZimelidineThe serum concentration of Estriol can be increased when it is combined with Zimelidine.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription fact...
Gene Name:
ESR1
Uniprot ID:
P03372
Molecular Weight:
66215.45 Da
References
  1. Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69. [PubMed:2011412 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by...
Gene Name:
ESR2
Uniprot ID:
Q92731
Molecular Weight:
59215.765 Da
References
  1. Mishra RG, Stanczyk FZ, Burry KA, Oparil S, Katzenellenbogen BS, Nealen ML, Katzenellenbogen JA, Hermsmeyer RK: Metabolite ligands of estrogen receptor-beta reduce primate coronary hyperreactivity. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H295-303. Epub 2005 Sep 30. [PubMed:16199482 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL: Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31. [PubMed:8779894 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Kim WY, Benet LZ: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. [PubMed:15290871 ]
Comments
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Drug created on September 07, 2007 15:04 / Updated on August 17, 2016 12:24