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Identification
NamePrednisone
Accession NumberDB00635  (APRD00340)
TypeSmall Molecule
GroupsApproved, Vet Approved
DescriptionA synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. [PubChem]
Structure
Thumb
Synonyms
1,2-Dehydrocortisone
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
Dehydrocortisone
Prednisona
Prednisonum
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alti-prednisone Tab 5mgtablet5 mgoralAltimed Pharma Inc.1984-12-311998-08-10Canada
Deltasone 50mgtablet50 mgoralPharmacia & Upjohn Inc1972-12-312000-08-02Canada
Deltasone 5mgtablet5 mgoralPharmacia & Upjohn Inc1972-12-312000-08-02Canada
Jaa Prednisone Tab 1mg USPtablet1.0 mgoralJaapharm Canada Inc.1993-05-15Not applicableCanada
Jaa Prednisone Tab 50mg USPtablet50 mgoralJaapharm Canada Inc.1993-12-31Not applicableCanada
Jaa Prednisone Tab 5mg USPtablet5 mgoralJaapharm Canada Inc.1993-12-31Not applicableCanada
Nu-prednisonetablet50 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-prednisonetablet1 mgoralNu Pharm IncNot applicableNot applicableCanada
Nu-prednisonetablet5 mgoralNu Pharm IncNot applicableNot applicableCanada
Prednisone 50 Tab 50mgtablet50 mgoralPro Doc Limitee1994-12-312016-07-18Canada
Prednisone Tab 5mgtablet5 mgoralPro Doc Limitee1959-12-31Not applicableCanada
Prednisone Tab 5mgtablet5 mgEverest Pharmaceuticals Ltd.1980-12-311999-07-14Canada
Rayostablet, delayed release1 mg/1oralHorizon Pharma Inc.2012-07-27Not applicableUs
Rayostablet, delayed release2 mg/1oralHorizon Pharma Inc.2012-07-27Not applicableUs
Rayostablet, delayed release5 mg/1oralHorizon Pharma Inc.2012-07-27Not applicableUs
Teva-prednisonetablet50 mgoralTeva Canada Limited1972-12-31Not applicableCanada
Teva-prednisonetablet5 mgoralTeva Canada Limited1967-12-31Not applicableCanada
Winpred Tab 1mgtablet1 mgoralAa Pharma Inc1978-12-31Not applicableCanada
Winpred Tab 5mgtablet5 mgoralValeant Canada Lp Valeant Canada S.E.C.1985-12-312013-07-30Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Prednisone Tab 1mg USPtablet1 mgoralApotex Inc1984-12-31Not applicableCanada
Apo Prednisone Tab 50mgtablet50 mgoralApotex Inc1982-12-31Not applicableCanada
Apo Prednisone Tab 5mgtablet5 mgoralApotex Inc1982-12-31Not applicableCanada
Deltasonetablet20 mg/20mgoralOculus Innovative Sciences2009-08-03Not applicableUs
Perrigo Prednisonetablet5 mg/1oralPerrigo Pharmaceuticals Company2006-05-19Not applicableUs
Perrigo Prednisonetablet20 mg/1oralPerrigo Pharmaceuticals Company2006-10-11Not applicableUs
Perrigo Prednisonetablet10 mg/1oralPerrigo Pharmaceuticals Company2006-05-19Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2012-09-13Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2012-09-12Not applicableUs
Prednisonetablet20 mg/1oralBlenheim Pharmacal, Inc.2013-07-31Not applicableUs
Prednisonetablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Prednisonetablet10 mg/1oralRebel Distributors Corp1985-12-04Not applicableUs
Prednisonetablet10 mg/1oralPhysicians Total Care, Inc.2002-04-11Not applicableUs
Prednisonetablet5 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC1972-05-22Not applicableUs
Prednisonetablet20 mg/1oralClinical Solutions Wholesale, Llc2009-08-03Not applicableUs
Prednisonetablet2.5 mg/1oralDispensing Solutions, Inc.1982-04-22Not applicableUs
Prednisonetablet10 mg/1oralAmerican Health Packaging2015-08-11Not applicableUs
Prednisonetablet20 mg/1oralPreferred Pharmaceuticals, Inc.2014-03-03Not applicableUs
Prednisonetablet50 mg/1oralProficient Rx LP2003-03-14Not applicableUs
Prednisonetablet5 mg/1oralC.O. Truxton, Inc.1972-04-21Not applicableUs
Prednisonetablet10 mg/1oralDepartment Of State Health Services, Pharmacy Branch2002-07-12Not applicableUs
Prednisonetablet2.5 mg/1oralRoxane Laboratories, Inc.1982-04-22Not applicableUs
Prednisonetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2009-08-03Not applicableUs
Prednisonetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.1972-05-22Not applicableUs
Prednisonetablet5 mg/1oralREMEDYREPACK INC.2010-11-09Not applicableUs
Prednisonetablet20 mg/1oralA S Medication Solutions Llc2009-08-03Not applicableUs
Prednisonetablet2.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1982-04-22Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2014-08-01Not applicableUs
Prednisonetablet5 mg/1oralA S Medication Solutions Llc1972-04-21Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2013-01-18Not applicableUs
Prednisonetablet50 mg/1oralCardinal Health2003-03-14Not applicableUs
Prednisonetablet10 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-07-12Not applicableUs
Prednisonetablet5 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2001-08-29Not applicableUs
Prednisonetablet10 mg/1oralKeltman Pharmaceuticals Inc.2008-07-07Not applicableUs
Prednisonetablet5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Prednisonetablet20 mg/1oralWest Ward Pharmaceuticals Corp1974-02-26Not applicableUs
Prednisonetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-08-29Not applicableUs
Prednisonetablet20 mg/1oralBlenheim Pharmacal, Inc.2015-05-20Not applicableUs
Prednisonetablet10 mg/1oralRoxane Laboratories, Inc.2003-02-13Not applicableUs
Prednisonetablet2.5 mg/1oralRoxane Laboratories, Inc.1982-04-22Not applicableUs
Prednisonetablet5 mg/1oralPerrigo New York Inc2006-10-02Not applicableUs
Prednisonetablet5 mg/1oralA S Medication Solutions Llc2009-08-03Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Prednisonetablet20 mg/1oralBlenheim Pharmacal, Inc.2010-03-17Not applicableUs
Prednisonetablet20 mg/1oralA S Medication Solutions Llc1974-02-26Not applicableUs
Prednisonetablet10 mg/1oralRebel Distributors Corp2002-07-12Not applicableUs
Prednisonetablet1 mg/1oralCardinal Health1982-04-22Not applicableUs
Prednisonetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC1972-04-21Not applicableUs
Prednisonetablet5 mg/1oralHikma Pharmaceutical1972-05-22Not applicableUs
Prednisonetablet10 mg/1oralRed Pharm Drug Inc.2002-07-12Not applicableUs
Prednisonetablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Prednisonetablet10 mg/1oralMc Kesson Contract Packaging2011-12-20Not applicableUs
Prednisonetablet50 mg/1oralbryant ranch prepack2003-03-14Not applicableUs
Prednisonetablet10 mg/1oralQualitest Pharmaceuticals2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralA S Medication Solutions1974-02-26Not applicableUs
Prednisonetablet2.5 mg/1oralDepartment Of State Health Services, Pharmacy Branch2004-12-21Not applicableUs
Prednisonesolution5 mg/mLoralRoxane Laboratories, Inc.1986-12-13Not applicableUs
Prednisonetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2009-08-03Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2013-02-28Not applicableUs
Prednisonetablet20 mg/201oralNorthwind Pharmaceuticals2014-04-29Not applicableUs
Prednisonetablet10 mg/1oralBlenheim Pharmacal, Inc.2011-06-15Not applicableUs
Prednisonetablet20 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Prednisonetablet5 mg/1oralSTAT Rx USA LLC1972-05-22Not applicableUs
Prednisonetablet50 mg/1oralPhysicians Total Care, Inc.2009-12-10Not applicableUs
Prednisonetablet5 mg/1oralAidarex Pharmaceuticals LLC2002-07-12Not applicableUs
Prednisonetablet5 mg/1oralLake Erie Medical DBA Quality Care Products LLC2002-07-12Not applicableUs
Prednisonetablet5 mg/1oralMed Vantx, Inc.2002-07-12Not applicableUs
Prednisonetablet10 mg/1oralGolden State Medical Supply, Inc.2009-08-03Not applicableUs
Prednisonetablet20 mg/1oralPreferred Pharmaceuticals, Inc.2011-07-21Not applicableUs
Prednisonetablet10 mg/1oralProficient Rx LP2002-07-12Not applicableUs
Prednisonetablet5 mg/1oralLiberty Pharmaceuticals, Inc.1987-11-01Not applicableUs
Prednisonetablet5 mg/1oralAphena Pharma Solutions Tennessee, Inc.1972-04-21Not applicableUs
Prednisonetablet5 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-30Not applicableUs
Prednisonetablet5 mg/1oralREMEDYREPACK INC.2012-10-02Not applicableUs
Prednisonetablet1 mg/1oralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs
Prednisonetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Prednisonetablet20 mg/1oralRebel Distributors Corp1974-02-26Not applicableUs
Prednisonetablet5 mg/1oralPhysicians Total Care, Inc.2002-11-27Not applicableUs
Prednisonetablet20 mg/1oralLake Erie Medical & Surgial Supply DBA Quality Care Products LLC1974-02-26Not applicableUs
Prednisonetablet5 mg/1oralClinical Solutions Wholesale1972-04-21Not applicableUs
Prednisonetablet1 mg/1oralDispensing Solutions, Inc.1982-04-22Not applicableUs
Prednisonetablet20 mg/1oralAmerican Health Packaging2015-09-01Not applicableUs
Prednisonetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2014-04-23Not applicableUs
Prednisonetablet10 mg/1oralbryant ranch prepack2002-07-12Not applicableUs
Prednisonetablet1 mg/1oralQualitest Pharmaceuticals2004-12-21Not applicableUs
Prednisonetablet5 mg/1oralActavis Pharma, Inc.1987-11-01Not applicableUs
Prednisonesolution5 mg/mLoralRoxane Laboratories, Inc.1984-11-08Not applicableUs
Prednisonetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2012-03-01Not applicableUs
Prednisonetablet5 mg/1oralUnit Dose Services1972-04-21Not applicableUs
Prednisonetablet10 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-02-13Not applicableUs
Prednisonetablet10 mg/1oralH.J. Harkins Company, Inc.2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralApotheca Inc.1974-02-26Not applicableUs
Prednisonetablet10 mg/1oralA S Medication Solutions Llc2002-07-12Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2014-02-06Not applicableUs
Prednisonetablet10 mg/1oralCardinal Health2003-02-13Not applicableUs
Prednisonetablet20 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2003-02-12Not applicableUs
Prednisonetablet10 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2001-08-29Not applicableUs
Prednisonetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2013-06-19Not applicableUs
Prednisonetablet10 mg/1oralDIRECT RX2014-01-01Not applicableUs
Prednisonetablet20 mg/1oralWest Ward Pharmaceuticals Corp2009-08-03Not applicableUs
Prednisonetablet10 mg/1oralAse Direct, Inc.2001-08-29Not applicableUs
Prednisonetablet20 mg/1oralRoxane Laboratories, Inc.2003-02-13Not applicableUs
Prednisonetablet1 mg/1oralWest ward Pharmaceutical Corp2010-11-012015-12-29Us
Prednisonetablet1 mg/1oralbryant ranch prepack2004-12-21Not applicableUs
Prednisonetablet20 mg/1oralQualitest Pharmaceuticals2003-02-12Not applicableUs
Prednisonetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2009-08-03Not applicableUs
Prednisonetablet2.5 mg/1oralWest Ward Pharmaceuticals Corp2004-01-08Not applicableUs
Prednisonetablet5 mg/1oralMedsource Pharmaceuticals2002-07-12Not applicableUs
Prednisonetablet5 mg/1oralA S Medication Solutions Llc2009-08-03Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs
Prednisonetablet10 mg/1oralBlenheim Pharmacal, Inc.2013-10-03Not applicableUs
Prednisonetablet50 mg/1oralA S Medication Solutions Llc2003-03-14Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2015-10-26Not applicableUs
Prednisonetablet5 mg/1oralCardinal Health1972-04-21Not applicableUs
Prednisonetablet20 mg/1oralSTAT Rx USA LLC1974-02-26Not applicableUs
Prednisonetablet10 mg/1oralHikma Pharmaceutical1985-12-04Not applicableUs
Prednisonesolution5 mg/mLoralCarilion Materials Management1986-12-13Not applicableUs
Prednisonetablet20 mg/1oralDIRECT RX2014-01-01Not applicableUs
Prednisonetablet10 mg/1oralDispensing Solutions, Inc.2003-02-13Not applicableUs
Prednisonetablet20 mg/1oralGolden State Medical Supply, Inc.2009-08-03Not applicableUs
Prednisonetablet20 mg/1oralPreferred Pharmaceuticals, Inc.2015-03-26Not applicableUs
Prednisonetablet5 mg/1oralProficient Rx LP2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralLiberty Pharmaceuticals, Inc.2009-08-03Not applicableUs
Prednisonetablet5 mg/1oralDepartment Of State Health Services, Pharmacy Branch2002-07-12Not applicableUs
Prednisonetablet5 mg/1oralRoxane Laboratories, Inc.1972-04-21Not applicableUs
Prednisonetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2009-08-03Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2011-09-26Not applicableUs
Prednisonetablet10 mg/201oralNorthwind Pharmaceuticals2014-04-28Not applicableUs
Prednisonetablet10 mg/1oralBlenheim Pharmacal, Inc.2011-07-05Not applicableUs
Prednisonetablet5 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Prednisonetablet10 mg/1oralSTAT Rx USA LLC2006-05-19Not applicableUs
Prednisonetablet1 mg/1oralPhysicians Total Care, Inc.2004-10-05Not applicableUs
Prednisonetablet10 mg/1oralAidarex Pharmaceuticals LLC2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2009-08-03Not applicableUs
Prednisonetablet5 mg/1oralAphena Pharma Solutions Tennessee, Llc1987-11-01Not applicableUs
Prednisonetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-08-11Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2013-06-17Not applicableUs
Prednisonetablet20 mg/1oralBlenheim Pharmacal, Inc.2014-02-25Not applicableUs
Prednisonetablet5 mg/1oralA S Medication Solutions Llc1972-04-21Not applicableUs
Prednisonetablet1 mg/1oralRebel Distributors Corp1982-04-22Not applicableUs
Prednisonetablet5 mg/1oralPhysicians Total Care, Inc.2005-02-25Not applicableUs
Prednisonetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC1987-11-01Not applicableUs
Prednisonetablet10 mg/1oralClinical Solutions Wholesale2002-07-12Not applicableUs
Prednisonetablet10 mg/1oralRed Pharm Drug Inc.1987-11-01Not applicableUs
Prednisonetablet5 mg/1oralSt Marys Medical Park Pharmacy2013-08-15Not applicableUs
Prednisonetablet20 mg/1oralbryant ranch prepack2003-02-12Not applicableUs
Prednisonetablet2.5 mg/1oralQualitest Pharmaceuticals2004-12-21Not applicableUs
Prednisonetablet10 mg/1oralActavis Pharma, Inc.1987-11-01Not applicableUs
Prednisonetablet5 mg/1oralRoxane Laboratories, Inc.1972-04-21Not applicableUs
Prednisonetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.1974-02-26Not applicableUs
Prednisonetablet50 mg/1oralREMEDYREPACK INC.2011-11-03Not applicableUs
Prednisonetablet10 mg/1oralUnit Dose Services1985-12-04Not applicableUs
Prednisonetablet1 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1982-04-22Not applicableUs
Prednisonetablet20 mg/1oralH.J. Harkins Company, Inc.2003-02-12Not applicableUs
Prednisonetablet20 mg/1oralSTAT Rx USA LLC1974-02-26Not applicableUs
Prednisonetablet5 mg/1oralPhysicians Total Care, Inc.2002-03-12Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2013-03-20Not applicableUs
Prednisonetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.2003-02-13Not applicableUs
Prednisonetablet20 mg/1oralMc Kesson Packaging Services A Business Unit Or Mc Kesson Corporation1987-11-01Not applicableUs
Prednisonetablet20 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2001-08-29Not applicableUs
Prednisonetablet5 mg/1oralPreferred Pharmaceuticals, Inc.2011-07-21Not applicableUs
Prednisonetablet50 mg/1oralDIRECT RX2015-01-01Not applicableUs
Prednisonetablet10 mg/1oralWest Ward Pharmaceuticals Corp2009-08-03Not applicableUs
Prednisonetablet50 mg/1oralRoxane Laboratories, Inc.2003-03-14Not applicableUs
Prednisonetablet20 mg/1oralHikma Pharmaceutical1974-02-26Not applicableUs
Prednisonetablet5 mg/1oralDispensing Solutions Inc.2008-05-29Not applicableUs
Prednisonetablet20 mg/1oralDIRECT RX2015-01-01Not applicableUs
Prednisonetablet20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-08-29Not applicableUs
Prednisonetablet2.5 mg/1oralbryant ranch prepack2004-12-21Not applicableUs
Prednisonetablet5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs1972-04-21Not applicableUs
Prednisonetablet5 mg/1oralBlenheim Pharmacal, Inc.2015-05-18Not applicableUs
Prednisonetablet10 mg/1oralWest Ward Pharmaceuticals Corp1985-12-04Not applicableUs
Prednisonetablet10 mg/1oralMedsource Pharmaceuticals2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralA S Medication Solutions Llc2009-08-03Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2013-11-12Not applicableUs
Prednisonetablet10 mg/1oralA S Medication Solutions Llc2003-02-13Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2011-12-13Not applicableUs
Prednisonetablet20 mg/1oralCardinal Health2003-02-13Not applicableUs
Prednisonetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2003-02-12Not applicableUs
Prednisonetablet20 mg/1oralPhysicians Total Care, Inc.2003-08-19Not applicableUs
Prednisonetablet5 mg/1oralAidarex Pharmaceuticals LLC2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralClinical Solutions Wholesale2003-02-13Not applicableUs
Prednisonetablet20 mg/1oralDispensing Solutions, Inc.2003-02-12Not applicableUs
Prednisonetablet5 mg/1oralAmerican Health Packaging2015-08-11Not applicableUs
Prednisonetablet20 mg/1oralPreferred Pharmaceuticals, Inc.2013-06-19Not applicableUs
Prednisonetablet20 mg/1oralProficient Rx LP2009-08-03Not applicableUs
Prednisonetablet20 mg/1oralC.O. Truxton, Inc.2003-02-13Not applicableUs
Prednisonetablet20 mg/1oralDepartment Of State Health Services, Pharmacy Branch2003-02-13Not applicableUs
Prednisonetablet1 mg/1oralRoxane Laboratories, Inc.1982-04-22Not applicableUs
Prednisonetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.2009-08-03Not applicableUs
Prednisonetablet5 mg/1oralREMEDYREPACK INC.2011-12-22Not applicableUs
Prednisonetablet5 mg/1oralREMEDYREPACK INC.2012-08-20Not applicableUs
Prednisonetablet10 mg/1oralBlenheim Pharmacal, Inc.2012-12-18Not applicableUs
Prednisonetablet10 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Prednisonetablet5 mg/1oralRebel Distributors Corp1972-05-22Not applicableUs
Prednisonetablet10 mg/1oralPerrigo New York Inc2006-05-19Not applicableUs
Prednisonetablet20 mg/1oralLake Erie Medical & Surgical Supply DBA Quality Care Products LLC2011-11-30Not applicableUs
Prednisonetablet5 mg/1oralREMEDYREPACK INC.2013-07-05Not applicableUs
Prednisonetablet10 mg/1oralBlenheim Pharmacal, Inc.2009-12-16Not applicableUs
Prednisonetablet10 mg/1oralA S Medication Solutions Llc2003-02-13Not applicableUs
Prednisonetablet5 mg/1oralRebel Distributors Corp2002-07-12Not applicableUs
Prednisonetablet10 mg/1oralPhysicians Total Care, Inc.2005-02-25Not applicableUs
Prednisonetablet20 mg/1oralLake Erie Medical DBA Quality Care Products LLC2003-02-13Not applicableUs
Prednisonetablet20 mg/1oralClinical Solutions Wholesale2009-08-03Not applicableUs
Prednisonetablet20 mg/1oralRed Pharm Drug Inc.2003-02-12Not applicableUs
Prednisonetablet20 mg/1oralREMEDYREPACK INC.2014-10-02Not applicableUs
Prednisonetablet5 mg/1oralMc Kesson Contract Packaging2011-10-12Not applicableUs
Prednisonetablet5 mg/1oralbryant ranch prepack2002-07-12Not applicableUs
Prednisonetablet5 mg/1oralQualitest Pharmaceuticals2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralActavis Pharma, Inc.1987-11-01Not applicableUs
Prednisonetablet1 mg/1oralRoxane Laboratories, Inc.1982-04-22Not applicableUs
Prednisonetablet20 mg/1oralPd Rx Pharmaceuticals, Inc.1987-11-01Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2011-08-30Not applicableUs
Prednisonetablet20 mg/1oralUnit Dose Services1974-02-26Not applicableUs
Prednisonetablet20 mg/1oralBlenheim Pharmacal, Inc.2011-06-15Not applicableUs
Prednisonetablet5 mg/1oralH.J. Harkins Company, Inc.2002-07-12Not applicableUs
Prednisonetablet5 mg/1oralSTAT Rx USA LLC2002-07-12Not applicableUs
Prednisonetablet10 mg/1oralPhysicians Total Care, Inc.2002-04-15Not applicableUs
Prednisonetablet20 mg/1oralAidarex Pharmaceuticals LLC2003-02-12Not applicableUs
Prednisonetablet5 mg/1oralPd Rx Pharmaceuticals, Inc.2002-07-12Not applicableUs
Prednisonetablet10 mg/1oralTYA Pharmaceuticals1985-12-04Not applicableUs
Prednisonetablet5 mg/1oralGolden State Medical Supply, Inc.2009-08-03Not applicableUs
Prednisonetablet10 mg/1oralPreferred Pharmaceuticals, Inc.2011-07-21Not applicableUs
Prednisonetablet5 mg/1oralProficient Rx LP2001-08-29Not applicableUs
Prednisonetablet5 mg/1oralWest Ward Pharmaceuticals Corp2009-08-03Not applicableUs
Prednisonetablet5 mg/1oralA S Medication Solutions Llc2002-07-12Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2013-02-13Not applicableUs
Prednisonetablet10 mg/1oralCardinal Health2003-02-13Not applicableUs
Prednisonetablet10 mg/1oralPd Rx Pharmaceuticals, Inc.1985-12-04Not applicableUs
Prednisonetablet1 mg/1oralJUBILANT CADISTA PHARMACEUTICALS, INC.2005-06-06Not applicableUs
Prednisonetablet20 mg/1oralKeltman Pharmaceuticals Inc.2007-04-23Not applicableUs
Prednisonetablet5 mg/1oralDIRECT RX2014-01-01Not applicableUs
Prednisonetablet10 mg/1oralLake Erie Medical DBA Quality Care Products LLC2001-08-29Not applicableUs
Prednisonetablet5 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2002-07-12Not applicableUs
Prednisonetablet20 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2003-02-13Not applicableUs
Prednisonetablet10 mg/1oralBlenheim Pharmacal, Inc.2015-05-18Not applicableUs
Prednisonetablet5 mg/1oralWest Ward Pharmaceuticals Corp1972-05-22Not applicableUs
Prednisonetablet20 mg/1oralSafecor Health, LLC2014-09-30Not applicableUs
Prednisonetablet20 mg/1oralA S Medication Solutions Llc2009-08-03Not applicableUs
Prednisonetablet10 mg/1oralREMEDYREPACK INC.2014-06-03Not applicableUs
Prednisone Intensolsolution, concentrate5 mg/mLoralRoxane Laboratories, Inc.1985-02-20Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
Delta-CortefUpjohn
MeticortenNot Available
OrasoneNot Available
Brand mixtures
NameLabellerIngredients
Metreton TabSchering Plough Canada Inc
SaltsNot Available
Categories
UNIIVB0R961HZT
CAS number53-03-2
WeightAverage: 358.4281
Monoisotopic: 358.178023942
Chemical FormulaC21H26O5
InChI KeyInChIKey=XOFYZVNMUHMLCC-ZPOLXVRWSA-N
InChI
InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
IUPAC Name
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-diene-5,17-dione
SMILES
[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • 21-hydroxysteroid
  • Progestogin-skeleton
  • Pregnane-skeleton
  • 20-oxosteroid
  • 17-hydroxysteroid
  • Oxosteroid
  • 11-oxosteroid
  • 3-oxosteroid
  • 3-oxo-delta-1,4-steroid
  • Delta-1,4-steroid
  • Cyclohexanone
  • Tertiary alcohol
  • Cyclic alcohol
  • Alpha-hydroxy ketone
  • Cyclic ketone
  • Ketone
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison's disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn's disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin's or non-Hodgkin's lynphomas, Waldenstrom's macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optoc neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler's syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis.
PharmacodynamicsPrednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has some mineralocorticoid activity and thus may affect ion exchange in the kidney.
Mechanism of actionPrednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisone can stimulate secretion of various components of gastric juice. Suppression of the production of corticotropin may lead to suppression of endogenous corticosteroids. Prednisone has slight mineralocorticoid activity, whereby entry of sodium into cells and loss of intracellular potassium is stimulated. This is particularly evident in the kidney, where rapid ion exchange leads to sodium retention and hypertension.
Related Articles
AbsorptionReadily absorbed from the gastrointestinal tract. Rayos, the delayed-release formulation, has a 4-hour release time. To compare, the delayed-release formulation has a Tmax of 6.0 - 6.5 hours in healthy male subjects, whereas the immediate-release formulation has a Tmax of 2.0 hours. The rate of absorption, Cmax, and exposure is comparable between formulations.
Volume of distributionNot Available
Protein bindingExtensively bound to plasma proteins.
Metabolism

Prednisone is completely converted to the active metabolite prednisolone by 11β-hydroxysteroid dehydrogenases. It is then further metabolized mainly in the liver. The exposure of prednisolone is 4-6 fold higher than that of prednisone.

SubstrateEnzymesProduct
Prednisone
PrednisoloneDetails
Route of eliminationExcreted in the urine as sulfate and glucuronide conjugates.
Half lifeHalf life of both the immediate- and delayed- release formulation is 2 to 3 hours.
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Prednisone Action PathwayDrug actionSMP00440
Prednisone Metabolism PathwayDrug metabolismSMP00631
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9918
Blood Brain Barrier+0.9383
Caco-2 permeable-0.5096
P-glycoprotein substrateSubstrate0.7861
P-glycoprotein inhibitor INon-inhibitor0.7847
P-glycoprotein inhibitor IINon-inhibitor0.8383
Renal organic cation transporterNon-inhibitor0.7463
CYP450 2C9 substrateNon-substrate0.8496
CYP450 2D6 substrateNon-substrate0.9138
CYP450 3A4 substrateSubstrate0.7407
CYP450 1A2 substrateNon-inhibitor0.9406
CYP450 2C9 inhibitorNon-inhibitor0.9072
CYP450 2D6 inhibitorNon-inhibitor0.9418
CYP450 2C19 inhibitorNon-inhibitor0.9253
CYP450 3A4 inhibitorNon-inhibitor0.8902
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9095
Ames testNon AMES toxic0.9132
CarcinogenicityNon-carcinogens0.9597
BiodegradationNot ready biodegradable0.925
Rat acute toxicity1.8914 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.95
hERG inhibition (predictor II)Non-inhibitor0.584
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Schering corp sub schering plough corp
  • Roxane laboratories inc
  • Wockhardt eu operations (swiss) ag
  • Muro pharmaceutical inc
  • Halsey drug co inc
  • Bayer pharmaceuticals corp
  • Pharmacia and upjohn co
  • Ferndale laboratories inc
  • Solvay pharmaceuticals
  • Parke davis div warner lambert co
  • Schwarz pharma inc
  • American therapeutics inc
  • Amneal pharmaceuticals ny llc
  • Cm bundy co
  • Cadista pharmaceuticals inc
  • Contract pharmacal corp
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Elkins sinn div ah robins co inc
  • Everylife
  • John j ferrante
  • Heather drug co inc
  • Impax laboratories inc
  • Inwood laboratories inc sub forest laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Kv pharmaceutical co
  • Lannett co inc
  • Lederle laboratories div american cyanamid co
  • Marshall pharmacal corp
  • Mutual pharmaceutical co inc
  • Nylos trading co inc
  • Panray corp sub ormont drug and chemical co inc
  • L perrigo co
  • Pharmavite pharmaceuticals
  • Phoenix laboratories inc
  • Purepac pharmaceutical co
  • Private formulations inc
  • Rexall drug co
  • Sandoz inc
  • Scherer laboratories inc
  • Sperti drug products inc
  • Superpharm corp
  • Teva pharmaceuticals usa inc
  • Udl laboratories inc
  • Upsher smith laboratories inc
  • Valeant pharmaceuticals international
  • Vangard laboratories inc div midway medical co
  • Vintage pharmaceuticals inc
  • Vitarine pharmaceuticals inc
  • Watson laboratories inc
  • West ward pharmaceutical corp
  • Whiteworth towne paulsen inc
Packagers
Dosage forms
FormRouteStrength
Tabletoral20 mg/20mg
Tabletoral1.0 mg
Tabletoral50 mg
Tabletoral5 mg
Tabletoral
Solutionoral5 mg/mL
Tabletoral1 mg/1
Tabletoral10 mg/1
Tabletoral10 mg/201
Tabletoral2.5 mg/1
Tabletoral20 mg/1
Tabletoral20 mg/201
Tabletoral5 mg/1
Tabletoral50 mg/1
Solution, concentrateoral5 mg/mL
Tablet5 mg
Tablet, delayed releaseoral1 mg/1
Tablet, delayed releaseoral2 mg/1
Tablet, delayed releaseoral5 mg/1
Tabletoral1 mg
Prices
Unit descriptionCostUnit
Sterapred DS 21 10 mg tablet Disp Pack64.0USD disp
Prednisone powder3.36USD g
Sterapred ds 10 mg tablet unipak2.93USD tablet
Prednisone 5 mg/ml solution1.17USD ml
PredniSONE 5 mg/5ml Solution0.5USD ml
Prednisone 50 mg tablet0.47USD tablet
Prednisone 20 mg tablet0.29USD tablet
Prednisone 10 mg tablet0.27USD tablet
Prednisone 2.5 mg tablet0.25USD tablet
Prednisone 1 mg tablet0.23USD tablet
Apo-Prednisone 50 mg Tablet0.18USD tablet
Winpred 1 mg Tablet0.12USD tablet
Apo-Prednisone 1 mg Tablet0.11USD tablet
Prednisone 5 mg tablet0.08USD tablet
Apo-Prednisone 5 mg Tablet0.04USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6488960 No2000-03-142020-03-14Us
US6677326 No2000-03-142020-03-14Us
US8168218 No2008-01-072028-01-07Us
US8309124 No2004-04-232024-04-23Us
US8394407 No2004-04-232024-04-23Us
US9040085 No2004-04-232024-04-23Us
US9186332 No2004-04-232024-04-23Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point230 - 235 °C (decomposes)MSDS
water solubilityVery slightly solubleMSDS
logP1.46MSDS
Predicted Properties
PropertyValueSource
Water Solubility0.111 mg/mLALOGPS
logP2.07ALOGPS
logP1.66ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)12.58ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area91.67 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity97.57 m3·mol-1ChemAxon
Polarizability38.17 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (12.5 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-05fs-2951000000-1a9b3a7e18f6088d28dbView in MoNA
References
Synthesis Reference

Jean Buendia, Michel Vivat, “Process for the production of prednisone 17.21-diacylates.” U.S. Patent US4601854, issued May, 1982.

US4601854
General ReferencesNot Available
External Links
ATC CodesH02AB07A07EA03
AHFS Codes
  • 68:04.00
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (132 KB)
Interactions
Drug Interactions
Drug
1,10-PhenanthrolineThe risk or severity of adverse effects can be increased when Prednisone is combined with 1,10-Phenanthroline.
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Prednisone.
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Prednisone.
AcetaminophenThe serum concentration of Prednisone can be increased when it is combined with Acetaminophen.
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Prednisone.
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Prednisone.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Prednisone.
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Prednisone.
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Prednisone.
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Prednisone.
AlbendazoleThe serum concentration of Prednisone can be increased when it is combined with Albendazole.
AldesleukinPrednisone may decrease the antineoplastic activities of Aldesleukin.
AldosteroneThe serum concentration of Prednisone can be decreased when it is combined with Aldosterone.
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Prednisone.
AlectinibThe serum concentration of Prednisone can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Prednisone can be increased when it is combined with Alfentanil.
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Prednisone.
AlogliptinThe therapeutic efficacy of Alogliptin can be decreased when used in combination with Prednisone.
Aluminum hydroxideThe bioavailability of Prednisone can be decreased when combined with Aluminum hydroxide.
Aluminum phosphateThe bioavailability of Prednisone can be decreased when combined with Aluminum phosphate.
AmantadineThe serum concentration of Prednisone can be increased when it is combined with Amantadine.
AmbenoniumThe risk or severity of adverse effects can be increased when Prednisone is combined with Ambenonium.
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Prednisone.
Aminohippuric acidThe serum concentration of Prednisone can be increased when it is combined with Aminohippuric acid.
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Prednisone.
AmiodaroneThe serum concentration of Prednisone can be increased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Prednisone can be increased when it is combined with Amitriptyline.
AmlodipineThe serum concentration of Prednisone can be increased when it is combined with Amlodipine.
Amphotericin BPrednisone may increase the hypokalemic activities of Amphotericin B.
AmprenavirThe serum concentration of Prednisone can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Prednisone can be increased when it is combined with Amsacrine.
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Prednisone.
AprepitantThe serum concentration of Prednisone can be increased when it is combined with Aprepitant.
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Prednisone.
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Prednisone.
AstemizoleThe serum concentration of Prednisone can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Prednisone can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Prednisone can be increased when it is combined with Atenolol.
AtomoxetineThe metabolism of Prednisone can be decreased when combined with Atomoxetine.
AtorvastatinThe serum concentration of Prednisone can be increased when it is combined with Atorvastatin.
Atracurium besylateAtracurium besylate may increase the adverse neuromuscular activities of Prednisone.
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Prednisone.
AzelastineThe serum concentration of Prednisone can be increased when it is combined with Azelastine.
AzithromycinThe serum concentration of Prednisone can be increased when it is combined with Azithromycin.
BazedoxifeneThe serum concentration of Prednisone can be increased when it is combined with Bazedoxifene.
BendroflumethiazidePrednisone may increase the hypokalemic activities of Bendroflumethiazide.
BenzocaineThe serum concentration of Prednisone can be increased when it is combined with Benzocaine.
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Prednisone.
BepridilThe serum concentration of Prednisone can be increased when it is combined with Bepridil.
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Prednisone.
BevacizumabBevacizumab may increase the cardiotoxic activities of Prednisone.
BexaroteneThe serum concentration of Prednisone can be decreased when it is combined with Bexarotene.
BiperidenThe serum concentration of Prednisone can be increased when it is combined with Biperiden.
Bismuth SubcitrateThe bioavailability of Prednisone can be decreased when combined with Bismuth Subcitrate.
BoceprevirThe serum concentration of Prednisone can be increased when it is combined with Boceprevir.
BortezomibThe metabolism of Prednisone can be decreased when combined with Bortezomib.
BosentanThe serum concentration of Prednisone can be decreased when it is combined with Bosentan.
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Prednisone.
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Prednisone.
BromocriptineThe serum concentration of Prednisone can be increased when it is combined with Bromocriptine.
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Prednisone.
BumetanidePrednisone may increase the hypokalemic activities of Bumetanide.
BuprenorphineThe serum concentration of Prednisone can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Prednisone can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Prednisone.
CaffeineThe serum concentration of Prednisone can be increased when it is combined with Caffeine.
CalcitriolThe therapeutic efficacy of Calcitriol can be decreased when used in combination with Prednisone.
Calcium carbonateThe bioavailability of Prednisone can be decreased when combined with Calcium carbonate.
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Prednisone.
CanagliflozinThe therapeutic efficacy of Canagliflozin can be decreased when used in combination with Prednisone.
CanagliflozinThe serum concentration of Prednisone can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Prednisone can be increased when it is combined with Candesartan.
CaptoprilThe serum concentration of Prednisone can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Prednisone can be decreased when it is combined with Carbamazepine.
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Prednisone.
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Prednisone.
CarvedilolThe serum concentration of Prednisone can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Prednisone can be increased when it is combined with Caspofungin.
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Prednisone.
CeritinibThe serum concentration of Prednisone can be increased when it is combined with Ceritinib.
CeritinibPrednisone may increase the hyperglycemic activities of Ceritinib.
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Prednisone.
ChloroquineThe serum concentration of Prednisone can be increased when it is combined with Chloroquine.
ChlorothiazidePrednisone may increase the hypokalemic activities of Chlorothiazide.
ChlorotrianiseneThe serum concentration of Prednisone can be increased when it is combined with Chlorotrianisene.
ChlorpromazineThe serum concentration of Prednisone can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Prednisone.
ChlorpropamideThe serum concentration of Prednisone can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Prednisone can be increased when it is combined with Chlorprothixene.
ChlorthalidonePrednisone may increase the hypokalemic activities of Chlorthalidone.
CholesterolThe serum concentration of Prednisone can be increased when it is combined with Cholesterol.
CholestyramineCholestyramine can cause a decrease in the absorption of Prednisone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholic AcidThe serum concentration of Prednisone can be decreased when it is combined with Cholic Acid.
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Prednisone.
CilazaprilThe serum concentration of Prednisone can be increased when it is combined with Cilazapril.
CimetidineThe serum concentration of Prednisone can be decreased when it is combined with Cimetidine.
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Prednisone.
CiprofloxacinThe serum concentration of Prednisone can be increased when it is combined with Ciprofloxacin.
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Prednisone.
CitalopramThe serum concentration of Prednisone can be increased when it is combined with Citalopram.
ClarithromycinThe serum concentration of Prednisone can be increased when it is combined with Clarithromycin.
ClemastineThe metabolism of Prednisone can be decreased when combined with Clemastine.
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Prednisone.
ClofazimineThe serum concentration of Prednisone can be increased when it is combined with Clofazimine.
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Prednisone.
ClomipramineThe serum concentration of Prednisone can be increased when it is combined with Clomipramine.
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Prednisone.
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Prednisone.
ClotrimazoleThe metabolism of Prednisone can be decreased when combined with Clotrimazole.
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Prednisone.
CobicistatThe serum concentration of Prednisone can be increased when it is combined with Cobicistat.
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Prednisone.
ColchicineThe serum concentration of Prednisone can be increased when it is combined with Colchicine.
ColesevelamColesevelam can cause a decrease in the absorption of Prednisone resulting in a reduced serum concentration and potentially a decrease in efficacy.
ColestipolColestipol can cause a decrease in the absorption of Prednisone resulting in a reduced serum concentration and potentially a decrease in efficacy.
ColforsinThe serum concentration of Prednisone can be increased when it is combined with Colforsin.
ConivaptanThe serum concentration of Prednisone can be increased when it is combined with Conivaptan.
Conjugated Equine EstrogensThe serum concentration of Prednisone can be increased when it is combined with Conjugated Equine Estrogens.
Corticorelin ovine triflutateThe therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Prednisone.
CoumaphosThe risk or severity of adverse effects can be increased when Prednisone is combined with Coumaphos.
CrizotinibThe metabolism of Prednisone can be decreased when combined with Crizotinib.
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Prednisone.
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Prednisone.
CyclosporineThe serum concentration of the active metabolites of Prednisone can be increased when Prednisone is used in combination with Cyclosporine.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Prednisone.
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Prednisone.
DabrafenibThe serum concentration of Prednisone can be decreased when it is combined with Dabrafenib.
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Prednisone.
DaclatasvirThe serum concentration of Prednisone can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Prednisone can be increased when it is combined with Dactinomycin.
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Prednisone.
DarunavirThe serum concentration of Prednisone can be increased when it is combined with Darunavir.
DasatinibThe serum concentration of Prednisone can be increased when it is combined with Dasatinib.
DaunorubicinThe serum concentration of Prednisone can be decreased when it is combined with Daunorubicin.
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Prednisone.
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Prednisone.
DecamethoniumThe risk or severity of adverse effects can be increased when Prednisone is combined with Decamethonium.
DeferasiroxThe serum concentration of Prednisone can be decreased when it is combined with Deferasirox.
DeferasiroxThe risk or severity of adverse effects can be increased when Prednisone is combined with Deferasirox.
DelavirdineThe metabolism of Prednisone can be decreased when combined with Delavirdine.
DemecariumThe risk or severity of adverse effects can be increased when Prednisone is combined with Demecarium.
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Prednisone.
DesipramineThe serum concentration of Prednisone can be increased when it is combined with Desipramine.
DeslanosideDeslanoside may decrease the cardiotoxic activities of Prednisone.
DesloratadineThe serum concentration of Prednisone can be increased when it is combined with Desloratadine.
DexamethasoneThe serum concentration of Prednisone can be decreased when it is combined with Dexamethasone.
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Prednisone.
DextromethorphanThe serum concentration of Prednisone can be increased when it is combined with Dextromethorphan.
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Prednisone.
DichlorvosThe risk or severity of adverse effects can be increased when Prednisone is combined with Dichlorvos.
DiclofenacThe serum concentration of Prednisone can be increased when it is combined with Diclofenac.
DienestrolThe serum concentration of Prednisone can be increased when it is combined with Dienestrol.
DiethylstilbestrolThe serum concentration of Prednisone can be increased when it is combined with Diethylstilbestrol.
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Prednisone.
DigitoxinDigitoxin may decrease the cardiotoxic activities of Prednisone.
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Prednisone.
DigoxinDigoxin may decrease the cardiotoxic activities of Prednisone.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Prednisone.
DihydroergotamineThe metabolism of Prednisone can be decreased when combined with Dihydroergotamine.
DihydrotestosteronePrednisone may increase the fluid retaining activities of Dihydrotestosterone.
DiltiazemThe metabolism of Prednisone can be decreased when combined with Diltiazem.
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Prednisone.
DipyridamoleThe serum concentration of Prednisone can be increased when it is combined with Dipyridamole.
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Prednisone.
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Prednisone.
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Prednisone.
DonepezilThe risk or severity of adverse effects can be increased when Prednisone is combined with Donepezil.
DoxazosinThe serum concentration of Prednisone can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Prednisone can be increased when it is combined with Doxepin.
DoxorubicinThe serum concentration of Prednisone can be decreased when it is combined with Doxorubicin.
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Prednisone.
DoxycyclineThe metabolism of Prednisone can be decreased when combined with Doxycycline.
DronabinolThe serum concentration of Prednisone can be increased when it is combined with Dronabinol.
DronedaroneThe metabolism of Prednisone can be decreased when combined with Dronedarone.
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Prednisone.
EchothiophateThe risk or severity of adverse effects can be increased when Prednisone is combined with Echothiophate.
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Prednisone.
EdrophoniumThe risk or severity of adverse effects can be increased when Prednisone is combined with Edrophonium.
EfavirenzThe serum concentration of Prednisone can be decreased when it is combined with Efavirenz.
ElbasvirThe serum concentration of Prednisone can be increased when it is combined with Elbasvir.
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Prednisone.
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Prednisone.
EnalaprilThe serum concentration of Prednisone can be increased when it is combined with Enalapril.
EnzalutamideThe serum concentration of Prednisone can be decreased when it is combined with Enzalutamide.
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Prednisone.
ErgonovineThe serum concentration of Prednisone can be increased when it is combined with Ergonovine.
ErgotamineThe serum concentration of Prednisone can be increased when it is combined with Ergotamine.
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Prednisone.
ErythromycinThe metabolism of Prednisone can be decreased when combined with Erythromycin.
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Prednisone.
Eslicarbazepine acetateThe serum concentration of Prednisone can be decreased when it is combined with Eslicarbazepine acetate.
EstradiolThe serum concentration of Prednisone can be increased when it is combined with Estradiol.
EstramustineThe serum concentration of Prednisone can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Prednisone can be increased when it is combined with Estriol.
EstroneThe serum concentration of Prednisone can be increased when it is combined with Estrone.
Etacrynic acidPrednisone may increase the hypokalemic activities of Etacrynic acid.
Ethinyl EstradiolThe serum concentration of Prednisone can be increased when it is combined with Ethinyl Estradiol.
EtoposideThe serum concentration of Prednisone can be increased when it is combined with Etoposide.
EtravirineThe serum concentration of Prednisone can be decreased when it is combined with Etravirine.
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Prednisone.
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Prednisone.
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Prednisone.
FelodipineThe serum concentration of Prednisone can be increased when it is combined with Felodipine.
FentanylThe serum concentration of Prednisone can be increased when it is combined with Fentanyl.
FenthionThe risk or severity of adverse effects can be increased when Prednisone is combined with Fenthion.
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Prednisone.
FexofenadineThe serum concentration of Prednisone can be increased when it is combined with Fexofenadine.
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Prednisone.
FingolimodPrednisone may increase the immunosuppressive activities of Fingolimod.
FluconazoleThe serum concentration of Prednisone can be increased when it is combined with Fluconazole.
FluoxetineThe serum concentration of Prednisone can be increased when it is combined with Fluoxetine.
FluoxymesteronePrednisone may increase the fluid retaining activities of Fluoxymesterone.
FlupentixolThe serum concentration of Prednisone can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Prednisone can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Prednisone can be increased when it is combined with Flurazepam.
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Prednisone.
FluvoxamineThe metabolism of Prednisone can be decreased when combined with Fluvoxamine.
FosamprenavirThe metabolism of Prednisone can be decreased when combined with Fosamprenavir.
FosaprepitantThe serum concentration of Prednisone can be increased when it is combined with Fosaprepitant.
FosphenytoinThe serum concentration of Prednisone can be decreased when it is combined with Fosphenytoin.
FurosemidePrednisone may increase the hypokalemic activities of Furosemide.
Fusidic AcidThe serum concentration of Prednisone can be increased when it is combined with Fusidic Acid.
GalantamineThe risk or severity of adverse effects can be increased when Prednisone is combined with Galantamine.
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Prednisone is combined with Gallamine Triethiodide.
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Prednisone.
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Prednisone.
GenisteinThe serum concentration of Prednisone can be increased when it is combined with Genistein.
Ginkgo bilobaThe risk or severity of adverse effects can be increased when Prednisone is combined with Ginkgo biloba.
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Prednisone.
GliclazideThe therapeutic efficacy of Gliclazide can be decreased when used in combination with Prednisone.
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Prednisone.
GlipizideThe therapeutic efficacy of Glipizide can be decreased when used in combination with Prednisone.
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Prednisone.
GlyburideThe therapeutic efficacy of Glyburide can be decreased when used in combination with Prednisone.
GlyburideThe serum concentration of Prednisone can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Prednisone can be increased when it is combined with Glycerol.
Glycerol PhenylbutyrateThe therapeutic efficacy of Glycerol Phenylbutyrate can be decreased when used in combination with Prednisone.
Gramicidin DThe serum concentration of Prednisone can be increased when it is combined with Gramicidin D.
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Prednisone.
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Prednisone.
HaloperidolThe serum concentration of Prednisone can be increased when it is combined with Haloperidol.
HexestrolThe serum concentration of Prednisone can be increased when it is combined with Hexestrol.
Huperzine AThe risk or severity of adverse effects can be increased when Prednisone is combined with Huperzine A.
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Prednisone.
HydrochlorothiazidePrednisone may increase the hypokalemic activities of Hydrochlorothiazide.
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Prednisone.
HydrocortisoneThe serum concentration of Prednisone can be increased when it is combined with Hydrocortisone.
HydroflumethiazidePrednisone may increase the hypokalemic activities of Hydroflumethiazide.
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Prednisone.
IdelalisibThe serum concentration of Prednisone can be increased when it is combined with Idelalisib.
ImatinibThe metabolism of Prednisone can be decreased when combined with Imatinib.
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Prednisone.
ImipramineThe serum concentration of Prednisone can be increased when it is combined with Imipramine.
IndacaterolIndacaterol may increase the hypokalemic activities of Prednisone.
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Prednisone.
IndapamidePrednisone may increase the hypokalemic activities of Indapamide.
IndinavirThe serum concentration of Prednisone can be increased when it is combined with Indinavir.
IndomethacinThe serum concentration of Prednisone can be increased when it is combined with Indomethacin.
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Prednisone.
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Prednisone.
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Prednisone.
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Prednisone.
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Prednisone.
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Prednisone.
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Prednisone.
IsavuconazoniumThe metabolism of Prednisone can be decreased when combined with Isavuconazonium.
IsoflurophateThe risk or severity of adverse effects can be increased when Prednisone is combined with Isoflurophate.
IsoniazidThe serum concentration of Isoniazid can be decreased when it is combined with Prednisone.
IsradipineThe metabolism of Prednisone can be decreased when combined with Isradipine.
ItraconazoleThe serum concentration of Prednisone can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Prednisone can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Prednisone can be increased when it is combined with Ivermectin.
KetamineThe serum concentration of Prednisone can be increased when it is combined with Ketamine.
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Prednisone.
KetoconazoleThe serum concentration of Prednisone can be increased when it is combined with Ketoconazole.
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Prednisone.
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Prednisone.
LansoprazoleThe serum concentration of Prednisone can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Prednisone can be increased when it is combined with Lapatinib.
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Prednisone.
LeflunomideThe risk or severity of adverse effects can be increased when Prednisone is combined with Leflunomide.
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Prednisone.
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Prednisone.
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Prednisone.
LevofloxacinThe serum concentration of Prednisone can be increased when it is combined with Levofloxacin.
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Prednisone.
LevothyroxineThe serum concentration of Prednisone can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Prednisone can be increased when it is combined with Lidocaine.
LinagliptinThe therapeutic efficacy of Linagliptin can be decreased when used in combination with Prednisone.
LiothyronineThe serum concentration of Prednisone can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Prednisone can be decreased when it is combined with Liotrix.
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Prednisone.
LisinoprilThe serum concentration of Prednisone can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Prednisone can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Prednisone can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Prednisone can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Prednisone can be increased when it is combined with Loratadine.
LosartanThe serum concentration of Prednisone can be increased when it is combined with Losartan.
LovastatinThe metabolism of Prednisone can be decreased when combined with Lovastatin.
LuliconazoleThe serum concentration of Prednisone can be increased when it is combined with Luliconazole.
LumacaftorThe serum concentration of Prednisone can be decreased when it is combined with Lumacaftor.
MagaldrateThe bioavailability of Prednisone can be decreased when combined with Magaldrate.
Magnesium carbonateThe bioavailability of Prednisone can be decreased when combined with Magnesium carbonate.
Magnesium hydroxideThe bioavailability of Prednisone can be decreased when combined with Magnesium hydroxide.
Magnesium oxideThe bioavailability of Prednisone can be decreased when combined with Magnesium oxide.
Magnesium TrisilicateThe bioavailability of Prednisone can be decreased when combined with Magnesium Trisilicate.
MalathionThe risk or severity of adverse effects can be increased when Prednisone is combined with Malathion.
MannitolThe serum concentration of Mannitol can be increased when it is combined with Prednisone.
MaprotilineThe serum concentration of Prednisone can be increased when it is combined with Maprotiline.
MebendazoleThe serum concentration of Prednisone can be increased when it is combined with Mebendazole.
MefloquineThe serum concentration of Prednisone can be increased when it is combined with Mefloquine.
MefloquineThe risk or severity of adverse effects can be increased when Prednisone is combined with Mefloquine.
Megestrol acetateThe serum concentration of Prednisone can be increased when it is combined with Megestrol acetate.
MemantineThe risk or severity of adverse effects can be increased when Prednisone is combined with Memantine.
MeprobamateThe serum concentration of Prednisone can be increased when it is combined with Meprobamate.
MesalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Prednisone.
MestranolThe serum concentration of Prednisone can be increased when it is combined with Mestranol.
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Prednisone.
MethadoneThe serum concentration of Prednisone can be increased when it is combined with Methadone.
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Prednisone.
MethyclothiazidePrednisone may increase the hypokalemic activities of Methyclothiazide.
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Prednisone.
MethyltestosteronePrednisone may increase the fluid retaining activities of Methyltestosterone.
MetolazonePrednisone may increase the hypokalemic activities of Metolazone.
MetoprololThe serum concentration of Prednisone can be increased when it is combined with Metoprolol.
MibefradilThe serum concentration of Prednisone can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Prednisone can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Prednisone can be decreased when it is combined with Midazolam.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Prednisone.
MifepristoneThe therapeutic efficacy of Prednisone can be decreased when used in combination with Mifepristone.
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Prednisone.
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Prednisone.
MinaprineThe risk or severity of adverse effects can be increased when Prednisone is combined with Minaprine.
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Prednisone.
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Prednisone.
MitomycinThe serum concentration of Prednisone can be increased when it is combined with Mitomycin.
MitotaneThe serum concentration of Prednisone can be decreased when it is combined with Mitotane.
MitoxantroneThe serum concentration of Prednisone can be decreased when it is combined with Mitoxantrone.
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Prednisone.
MivacuriumMivacurium may increase the adverse neuromuscular activities of Prednisone.
ModafinilThe serum concentration of Prednisone can be decreased when it is combined with Modafinil.
MorphineThe serum concentration of Prednisone can be increased when it is combined with Morphine.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Prednisone.
NadololThe serum concentration of Nadolol can be increased when it is combined with Prednisone.
NafcillinThe serum concentration of Prednisone can be decreased when it is combined with Nafcillin.
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Prednisone.
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Prednisone.
NaltrexoneThe serum concentration of Prednisone can be increased when it is combined with Naltrexone.
NaringeninThe serum concentration of Prednisone can be increased when it is combined with Naringenin.
NatalizumabThe risk or severity of adverse effects can be increased when Prednisone is combined with Natalizumab.
NateglinideThe therapeutic efficacy of Nateglinide can be decreased when used in combination with Prednisone.
NefazodoneThe serum concentration of Prednisone can be increased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Prednisone can be increased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Prednisone can be increased when it is combined with Neostigmine.
NeostigmineThe risk or severity of adverse effects can be increased when Prednisone is combined with Neostigmine.
NetupitantThe serum concentration of Prednisone can be increased when it is combined with Netupitant.
NevirapineThe serum concentration of Prednisone can be decreased when it is combined with Nevirapine.
NicardipineThe serum concentration of Prednisone can be increased when it is combined with Nicardipine.
NicorandilThe risk or severity of adverse effects can be increased when Prednisone is combined with Nicorandil.
NifedipineThe serum concentration of Prednisone can be decreased when it is combined with Nifedipine.
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Prednisone.
NilotinibThe metabolism of Prednisone can be decreased when combined with Nilotinib.
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Prednisone.
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Prednisone.
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Prednisone.
NisoldipineThe serum concentration of Prednisone can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Prednisone can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Prednisone can be increased when it is combined with Nitrendipine.
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Prednisone.
NorethisteroneThe serum concentration of Prednisone can be decreased when it is combined with Norethisterone.
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Prednisone.
OlaparibThe metabolism of Prednisone can be decreased when combined with Olaparib.
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Prednisone.
OmeprazoleThe serum concentration of Prednisone can be increased when it is combined with Omeprazole.
OsimertinibThe serum concentration of Prednisone can be increased when it is combined with Osimertinib.
OuabainOuabain may decrease the cardiotoxic activities of Prednisone.
OxandrolonePrednisone may increase the fluid retaining activities of Oxandrolone.
OxymetholonePrednisone may increase the fluid retaining activities of Oxymetholone.
P-NitrophenolThe serum concentration of Prednisone can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Prednisone can be increased when it is combined with Paclitaxel.
PalbociclibThe serum concentration of Prednisone can be increased when it is combined with Palbociclib.
Palmitic AcidThe serum concentration of Prednisone can be increased when it is combined with Palmitic Acid.
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Prednisone.
PantoprazoleThe serum concentration of Prednisone can be increased when it is combined with Pantoprazole.
ParoxetineThe serum concentration of Prednisone can be increased when it is combined with Paroxetine.
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Prednisone.
PentobarbitalThe serum concentration of Prednisone can be decreased when it is combined with Pentobarbital.
PerindoprilThe serum concentration of Prednisone can be increased when it is combined with Perindopril.
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Prednisone.
PhenobarbitalThe serum concentration of Prednisone can be decreased when it is combined with Phenobarbital.
PhenobarbitalThe serum concentration of Phenobarbital can be increased when it is combined with Prednisone.
Phenylacetic acidThe therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Prednisone.
PhenytoinThe serum concentration of Prednisone can be decreased when it is combined with Phenytoin.
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Prednisone.
PhysostigmineThe risk or severity of adverse effects can be increased when Prednisone is combined with Physostigmine.
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Prednisone.
PimozideThe serum concentration of Prednisone can be increased when it is combined with Pimozide.
PioglitazoneThe therapeutic efficacy of Pioglitazone can be decreased when used in combination with Prednisone.
PiretanidePrednisone may increase the hypokalemic activities of Piretanide.
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Prednisone.
Platelet Activating FactorThe serum concentration of Prednisone can be decreased when it is combined with Platelet Activating Factor.
Polyestradiol phosphateThe serum concentration of Prednisone can be increased when it is combined with Polyestradiol phosphate.
PolythiazidePrednisone may increase the hypokalemic activities of Polythiazide.
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Prednisone.
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Prednisone.
PosaconazoleThe serum concentration of Prednisone can be increased when it is combined with Posaconazole.
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Prednisone.
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Prednisone.
PrazosinThe serum concentration of Prednisone can be increased when it is combined with Prazosin.
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Prednisone.
PrimidoneThe serum concentration of Prednisone can be decreased when it is combined with Primidone.
ProbenecidThe serum concentration of Prednisone can be increased when it is combined with Probenecid.
ProgesteroneThe serum concentration of Prednisone can be decreased when it is combined with Progesterone.
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Prednisone.
PromethazineThe serum concentration of Prednisone can be increased when it is combined with Promethazine.
PropafenoneThe serum concentration of Prednisone can be increased when it is combined with Propafenone.
PropranololThe serum concentration of Prednisone can be increased when it is combined with Propranolol.
ProtriptylineThe serum concentration of Prednisone can be increased when it is combined with Protriptyline.
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Prednisone.
PyridostigmineThe risk or severity of adverse effects can be increased when Prednisone is combined with Pyridostigmine.
QuercetinThe serum concentration of Prednisone can be increased when it is combined with Quercetin.
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Prednisone.
QuinacrineThe serum concentration of Prednisone can be increased when it is combined with Quinacrine.
QuinestrolThe serum concentration of Prednisone can be increased when it is combined with Quinestrol.
QuinethazonePrednisone may increase the hypokalemic activities of Quinethazone.
QuinidineThe serum concentration of Prednisone can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Prednisone can be increased when it is combined with Quinine.
Rabies vaccineThe risk or severity of adverse effects can be increased when Prednisone is combined with Rabies vaccine.
RanitidineThe serum concentration of Prednisone can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Prednisone.
RapacuroniumRapacuronium may increase the adverse neuromuscular activities of Prednisone.
ReboxetineThe serum concentration of Prednisone can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Prednisone can be increased when it is combined with Regorafenib.
RepaglinideThe therapeutic efficacy of Repaglinide can be decreased when used in combination with Prednisone.
ReserpineThe serum concentration of Prednisone can be decreased when it is combined with Reserpine.
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Prednisone.
RifabutinThe serum concentration of Prednisone can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Prednisone can be decreased when it is combined with Rifampicin.
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Prednisone.
RifapentineThe serum concentration of Prednisone can be decreased when it is combined with Rifapentine.
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Prednisone.
RilpivirineThe serum concentration of Prednisone can be increased when it is combined with Rilpivirine.
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Prednisone.
RitonavirThe serum concentration of Prednisone can be increased when it is combined with Ritonavir.
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Prednisone.
RivastigmineThe risk or severity of adverse effects can be increased when Prednisone is combined with Rivastigmine.
RoflumilastRoflumilast may increase the immunosuppressive activities of Prednisone.
RolapitantThe serum concentration of Prednisone can be increased when it is combined with Rolapitant.
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Prednisone.
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Prednisone.
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Prednisone.
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Prednisone.
SaquinavirThe serum concentration of Prednisone can be increased when it is combined with Saquinavir.
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Prednisone.
ScopolamineThe serum concentration of Prednisone can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Prednisone can be increased when it is combined with Selegiline.
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Prednisone.
SertralineThe serum concentration of Prednisone can be increased when it is combined with Sertraline.
SildenafilThe metabolism of Prednisone can be decreased when combined with Sildenafil.
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Prednisone.
SiltuximabThe serum concentration of Prednisone can be decreased when it is combined with Siltuximab.
SimeprevirThe serum concentration of Prednisone can be increased when it is combined with Simeprevir.
SimvastatinThe serum concentration of Prednisone can be increased when it is combined with Simvastatin.
Sipuleucel-TThe therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Prednisone.
SirolimusThe serum concentration of Prednisone can be decreased when it is combined with Sirolimus.
SitagliptinThe therapeutic efficacy of Sitagliptin can be decreased when used in combination with Prednisone.
Sodium phenylbutyrateThe therapeutic efficacy of Sodium phenylbutyrate can be decreased when used in combination with Prednisone.
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Prednisone.
Somatropin recombinantThe therapeutic efficacy of Prednisone can be decreased when used in combination with Somatropin recombinant.
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Prednisone.
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Prednisone.
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Prednisone.
SpironolactoneThe serum concentration of Prednisone can be increased when it is combined with Spironolactone.
St. John's WortThe serum concentration of Prednisone can be decreased when it is combined with St. John's Wort.
StanozololPrednisone may increase the fluid retaining activities of Stanozolol.
StaurosporineThe serum concentration of Prednisone can be increased when it is combined with Staurosporine.
StiripentolThe serum concentration of Prednisone can be increased when it is combined with Stiripentol.
StreptozocinThe serum concentration of Prednisone can be decreased when it is combined with Streptozocin.
SulfinpyrazoneThe serum concentration of Prednisone can be increased when it is combined with Sulfinpyrazone.
SulfisoxazoleThe metabolism of Prednisone can be decreased when combined with Sulfisoxazole.
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Prednisone.
SumatriptanThe serum concentration of Prednisone can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Prednisone can be increased when it is combined with Sunitinib.
Synthetic Conjugated Estrogens, AThe serum concentration of Prednisone can be increased when it is combined with Synthetic Conjugated Estrogens, A.
Synthetic Conjugated Estrogens, BThe serum concentration of Prednisone can be increased when it is combined with Synthetic Conjugated Estrogens, B.
TacrineThe serum concentration of Prednisone can be increased when it is combined with Tacrine.
TacrineThe risk or severity of adverse effects can be increased when Prednisone is combined with Tacrine.
TacrolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Prednisone.
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Prednisone.
TamoxifenThe serum concentration of Prednisone can be decreased when it is combined with Tamoxifen.
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Prednisone.
Taurocholic AcidThe serum concentration of Prednisone can be increased when it is combined with Taurocholic Acid.
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Prednisone.
TelaprevirThe serum concentration of Prednisone can be increased when it is combined with Telaprevir.
TelithromycinThe serum concentration of Prednisone can be increased when it is combined with Telithromycin.
TelmisartanThe serum concentration of Prednisone can be increased when it is combined with Telmisartan.
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Prednisone.
TerazosinThe serum concentration of Prednisone can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Prednisone can be increased when it is combined with Terfenadine.
TesamorelinThe serum concentration of the active metabolites of Prednisone can be reduced when Prednisone is used in combination with Tesamorelin resulting in a loss in efficacy.
TesmilifeneThe serum concentration of Prednisone can be decreased when it is combined with Tesmilifene.
TestosteronePrednisone may increase the fluid retaining activities of Testosterone.
TestosteroneThe serum concentration of Prednisone can be increased when it is combined with Testosterone.
TiboloneThe serum concentration of Prednisone can be increased when it is combined with Tibolone.
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Prednisone.
TiclopidineThe metabolism of Prednisone can be decreased when combined with Ticlopidine.
TimololThe serum concentration of Timolol can be increased when it is combined with Prednisone.
TocilizumabThe serum concentration of Prednisone can be decreased when it is combined with Tocilizumab.
TofacitinibPrednisone may increase the immunosuppressive activities of Tofacitinib.
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Prednisone.
TolbutamideThe therapeutic efficacy of Tolbutamide can be decreased when used in combination with Prednisone.
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Prednisone.
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Prednisone.
TorasemidePrednisone may increase the hypokalemic activities of Torasemide.
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Prednisone.
TrastuzumabTrastuzumab may increase the neutropenic activities of Prednisone.
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Prednisone.
TrazodoneThe serum concentration of Prednisone can be decreased when it is combined with Trazodone.
TrichlorfonThe risk or severity of adverse effects can be increased when Prednisone is combined with Trichlorfon.
TrichlormethiazidePrednisone may increase the hypokalemic activities of Trichlormethiazide.
TrifluoperazineThe serum concentration of Prednisone can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Prednisone can be increased when it is combined with Triflupromazine.
TrimethoprimThe serum concentration of Prednisone can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Prednisone can be increased when it is combined with Trimipramine.
TroglitazoneThe therapeutic efficacy of Troglitazone can be decreased when used in combination with Prednisone.
TroleandomycinThe serum concentration of Prednisone can be increased when it is combined with Troleandomycin.
TubocurarineThe risk or severity of adverse effects can be increased when Prednisone is combined with Tubocurarine.
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Prednisone.
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Prednisone.
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Prednisone.
VenlafaxineThe metabolism of Prednisone can be decreased when combined with Venlafaxine.
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Prednisone.
VerapamilThe metabolism of Prednisone can be decreased when combined with Verapamil.
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Prednisone.
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Prednisone.
VinblastineThe serum concentration of Prednisone can be decreased when it is combined with Vinblastine.
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Prednisone.
VincristineThe serum concentration of Vincristine can be increased when it is combined with Prednisone.
VincristineThe serum concentration of Prednisone can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Prednisone can be increased when it is combined with Vinorelbine.
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Prednisone.
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Prednisone.
VoriconazoleThe serum concentration of Prednisone can be increased when it is combined with Voriconazole.
WarfarinPrednisone may increase the anticoagulant activities of Warfarin.
ZeranolThe serum concentration of Prednisone can be increased when it is combined with Zeranol.
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Prednisone.
ZimelidineThe serum concentration of Prednisone can be increased when it is combined with Zimelidine.
ZiprasidoneThe metabolism of Prednisone can be decreased when combined with Ziprasidone.
Food Interactions
  • Avoid alcohol.
  • Avoid taking with grapefruit juice.
  • Take with food to reduce irritation.
  • When Rayos, the delayed-release tablet, is taken without food, Cmax and bioavailability were lower compared to the fed state.

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon grow...
Gene Name:
NR3C1
Uniprot ID:
P04150
Molecular Weight:
85658.57 Da
References
  1. Liu BG, Li ZY, Du M: [Effects of jingui shenqi pill combined prednisone on expression of glucocorticoid receptor and its clinical effect in treating bullous pemphigoid patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Oct;26(10):881-4. [PubMed:17121036 ]
  2. Friel PN, Alexander T, Wright JV: Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6. [PubMed:16597193 ]
  3. Diez JJ, Iglesias P: Pharmacological therapy of Cushing's syndrome: drugs and indications. Mini Rev Med Chem. 2007 May;7(5):467-80. [PubMed:17504182 ]
  4. Yano A, Fujii Y, Iwai A, Kawakami S, Kageyama Y, Kihara K: Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6012-7. [PubMed:17062674 ]
  5. Yano A, Fujii Y, Iwai A, Kageyama Y, Kihara K: Glucocorticoids suppress tumor angiogenesis and in vivo growth of prostate cancer cells. Clin Cancer Res. 2006 May 15;12(10):3003-9. [PubMed:16707595 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
ligand
General Function:
11-beta-hydroxysteroid dehydrogenase [nad(p)] activity
Specific Function:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Gene Name:
HSD11B1
Uniprot ID:
P28845
Molecular Weight:
32400.665 Da
References
  1. Raza K, Hardy R, Cooper MS: The 11beta-hydroxysteroid dehydrogenase enzymes--arbiters of the effects of glucocorticoids in synovium and bone. Rheumatology (Oxford). 2010 Nov;49(11):2016-23. doi: 10.1093/rheumatology/keq212. Epub 2010 Jul 15. [PubMed:20634231 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Ferry JJ, Wagner JG: The nonlinear pharmacokinetics of prednisone and prednisolone. II. Plasma protein binding of prednisone and prednisolone in rabbit and human plasma. Biopharm Drug Dispos. 1987 May-Jun;8(3):261-72. [PubMed:3593903 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  2. Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. [PubMed:14661924 ]
  3. Dilger K, Schwab M, Fromm MF: Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein. Inflamm Bowel Dis. 2004 Sep;10(5):578-83. [PubMed:15472518 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. [PubMed:8786566 ]
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Drug created on June 13, 2005 07:24 / Updated on September 25, 2016 02:16