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Identification
NameAciclovir
Accession NumberDB00787  (APRD00567, EXPT00406, DB05347)
TypeSmall Molecule
GroupsApproved
DescriptionA guanosine analog antiviral drug that acts as an antimetabolite. Aciclovir is used for the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles). Aciclovir has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. Currently approved drugs for the treatment of herpes labialis (cold sores) exhibit low levels of efficacy due to the limited ability of the drugs to penetrate the skin to the site where the herpes virus is replicating. Iontophoresis uses electric current to enhance the delivery of drugs through the skin.
Structure
Thumb
Synonyms
Aciclovirum
Acycloguanosine
Acyclovir
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acyclovirtablet800 mg/1oralRebel Distributors Corp1998-10-30Not applicableUs
Acyclovirsuspension200 mg/5mLoralRenaissance Pharma, Inc.2014-09-03Not applicableUs
Acyclovirtablet200 mgoralSanis Health Inc2010-04-052014-08-01Canada
Acyclovirointment50 mg/gtopicalOceanside Pharmaceuticals2012-10-03Not applicableUs
Acyclovirtablet800 mgoralSanis Health Inc2010-04-052014-08-01Canada
Acyclovirointment50 mg/gtopicalActavis Pharma, Inc.2014-04-11Not applicableUs
Acyclovirtablet400 mgoralSanis Health Inc2010-04-05Not applicableCanada
Acyclovir Sodium for Injectionpowder for solution500 mgintravenousAbbott Laboratories, Limited1998-02-112007-07-31Canada
Acyclovir Sodium for Injectionpowder for solution1 gintravenousAbbott Laboratories, Limited1998-02-112007-07-31Canada
Acyclovir Sodium for Injectionpowder for solution500 mgintravenousNovopharm Limited1998-02-04Not applicableCanada
Acyclovir Sodium for Injectionpowder for solution1 gintravenousNovopharm Limited1998-02-042005-08-10Canada
Acyclovir Sodium Injectionsolution25 mgintravenousHospira Healthcare Corporation1998-03-18Not applicableCanada
Acyclovir Sodium Injectionsolution50 mgintravenousSterimax IncNot applicableNot applicableCanada
Acyclovir Sodium Injectionsolution25 mgintravenousIvax Pharmaceuticals IncorporatedNot applicableNot applicableCanada
Acyclovir Sodium Injectionsolution50 mgintravenousFresenius Kabi Canada Ltd1998-05-08Not applicableCanada
Acyclovir Sodium Injectionsolution50 mgintravenousFresenius Kabi Canada Ltd1998-05-08Not applicableCanada
Acyclovir-200tablet200 mgoralPro Doc Limitee1998-06-022010-07-13Canada
Acyclovir-400tablet400 mgoralPro Doc Limitee1998-06-022010-07-13Canada
Acyclovir-800tablet800 mgoralPro Doc Limitee1998-06-022010-07-13Canada
Alti-acyclovir - 400mgtablet400 mgoralAltimed Pharma Inc.1997-01-022001-09-05Canada
Alti-acyclovir - 800mgtablet800 mgoralAltimed Pharma Inc.1997-01-072005-05-27Canada
Alti-acyclovir - Tab 200mgtablet200 mgoralAltimed Pharma Inc.1997-01-022001-09-05Canada
Mylan-acyclovirtablet400 mgoralMylan Pharmaceuticals Ulc2000-06-30Not applicableCanada
Mylan-acyclovirtablet800 mgoralMylan Pharmaceuticals Ulc2000-06-30Not applicableCanada
Mylan-acyclovirtablet200 mgoralMylan Pharmaceuticals Ulc2000-09-14Not applicableCanada
Ntp-acyclovirtablet800 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-acyclovirtablet200 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Ntp-acyclovirtablet400 mgoralTeva Canada LimitedNot applicableNot applicableCanada
Nu-acyclovir - Tab 200mgtablet200 mgoralNu Pharm Inc1996-12-312012-09-04Canada
Nu-acyclovir - Tab 400mgtablet400 mgoralNu Pharm Inc1996-12-312012-09-04Canada
Nu-acyclovir - Tab 800mgtablet800 mgoralNu Pharm Inc1996-12-312012-09-04Canada
Ratio-acyclovirtablet200 mgoralTeva Canada Limited1994-12-31Not applicableCanada
Ratio-acyclovirtablet800 mgoralTeva Canada Limited1994-12-31Not applicableCanada
Ratio-acyclovirtablet400 mgoralTeva Canada Limited1994-12-31Not applicableCanada
Sitavigtablet, delayed release50 mg/1buccalCipher Pharmaceuticals Us Llc2014-03-20Not applicableUs
Teva-acyclovirtablet200 mgoralTeva Canada Limited2006-10-23Not applicableCanada
Teva-acyclovirtablet400 mgoralTeva Canada Limited2006-10-23Not applicableCanada
Teva-acyclovirtablet800 mgoralTeva Canada Limited2006-10-23Not applicableCanada
Zoviraxsuspension200 mg/5mLoralPrestium Pharma, Inc.2014-02-07Not applicableUs
Zoviraxtablet800 mg/1oralGlaxo Smith Kline Llc1991-05-07Not applicableUs
Zoviraxsuspension200 mgoralGlaxosmithkline Inc1991-12-31Not applicableCanada
Zoviraxcapsule200 mg/1oralREMEDYREPACK INC.2014-11-102016-04-05Us
Zoviraxcapsule200 mg/1oralPrestium Pharma, Inc.2014-02-07Not applicableUs
Zoviraxcream5 %topicalValeant Canada Lp Valeant Canada S.E.C.1993-12-31Not applicableCanada
Zoviraxointment50 mg/gtopicalValeant Pharmaceuticals North America LLC1982-03-29Not applicableUs
Zoviraxcapsule200 mg/1oralREMEDYREPACK INC.2015-02-16Not applicableUs
Zoviraxtablet800 mg/1oralPrestium Pharma, Inc.2014-02-07Not applicableUs
Zoviraxointment5 %topicalValeant Canada Lp Valeant Canada S.E.C.1982-12-31Not applicableCanada
Zoviraxcream50 mg/gtopicalValeant Pharmaceuticals North America LLC2002-12-30Not applicableUs
Zoviraxpowder for solution500 mgintravenousGlaxosmithkline Inc1983-12-312002-10-08Canada
Zoviraxtablet400 mg/1oralPrestium Pharma, Inc.2014-02-07Not applicableUs
Zoviraxcream50 mg/gtopicalRebel Distributors Corp2004-10-29Not applicableUs
Zoviraxpowder for solution1 gintravenousGlaxosmithkline Inc1992-12-312002-10-08Canada
Zovirax 400tablet400 mgoralGlaxosmithkline Inc1991-12-312014-02-20Canada
Zovirax 800tablet800 mgoralGlaxosmithkline Inc1991-12-312011-08-03Canada
Zovirax Cap 200mgcapsule200 mgoralGlaxo Wellcome Inc.1990-12-311997-08-13Canada
Zovirax Tab 200mgtablet200 mgoralGlaxosmithkline Inc1986-12-312016-01-11Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Acyclovirtablet800 mg/1oralApotheca Inc.2006-03-13Not applicableUs
Acyclovircapsule200 mg/1oralAidarex Pharmaceuticals LLC1997-04-23Not applicableUs
Acyclovirtablet400 mg/1oralApotex Corp.2007-06-09Not applicableUs
Acyclovirtablet800 mg/1oralUnit Dose Services2009-10-22Not applicableUs
Acyclovirtablet400 mg/1oralREMEDYREPACK INC.2011-07-13Not applicableUs
Acyclovirtablet400 mg/1oralProficient Rx LP2013-11-29Not applicableUs
Acyclovirtablet800 mg/1oralCadila Healthcare Limited2014-09-10Not applicableUs
Acyclovirointment50 mg/gtopicalMylan Institutional Inc.2013-11-27Not applicableUs
Acyclovircapsule200 mg/1oralCardinal Health2013-05-02Not applicableUs
Acyclovircapsule200 mg/1oralMajor Pharmaceuticals2007-04-19Not applicableUs
Acyclovirtablet400 mg/1oralBlenheim Pharmacal, Inc.2010-03-11Not applicableUs
Acyclovirtablet800 mg/1oralHeritage Pharmaceuticals Inc.2013-08-08Not applicableUs
Acyclovirtablet800 mg/1oralZydus Pharmaceuticals (USA) Inc.2014-09-10Not applicableUs
Acyclovirtablet800 mg/1oralClinical Solutions Wholesale1997-04-30Not applicableUs
Acyclovirtablet400 mg/1oralPreferred Pharmaceuticals Inc.2016-03-14Not applicableUs
Acyclovircapsule200 mg/1oralPd Rx Pharmaceuticals, Inc.2010-03-232016-04-05Us
Acyclovirtablet800 mg/1oralDIRECT RX2014-01-01Not applicableUs
Acyclovirtablet800 mg/1oralbryant ranch prepack1999-03-05Not applicableUs
Acyclovirtablet400 mg/1oralREMEDYREPACK INC.2013-02-21Not applicableUs
Acyclovirtablet800 mg/1oralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Acyclovircapsule200 mg/1oralTeva Pharmaceuticals USA Inc1997-04-23Not applicableUs
Acyclovircapsule200 mg/1oralH.J. Harkins Company, Inc.2011-05-27Not applicableUs
Acyclovircapsule200 mg/1oralPd Rx Pharmaceuticals, Inc.1997-04-23Not applicableUs
Acyclovirtablet400 mg/1oralBlenheim Pharmacal, Inc.2010-11-10Not applicableUs
Acyclovircapsule200 mg/1oralRebel Distributors Corp1998-10-30Not applicableUs
Acyclovirointment50 mg/gtopicalAv Kare, Inc.2015-02-05Not applicableUs
Acyclovirtablet800 mg/1oralPreferred Pharmaceuticals Inc.2016-02-01Not applicableUs
Acyclovirtablet800 mg/1oralCarlsbad Technology, Inc.2009-10-22Not applicableUs
Acyclovirtablet800 mg/1oralREMEDYREPACK INC.2011-08-01Not applicableUs
Acyclovircapsule200 mg/1oralRanbaxy Laboratories Ltd.1999-02-08Not applicableUs
Acyclovirtablet800 mg/1oralDAVA Pharmaceuticals, Inc.1997-11-19Not applicableUs
Acyclovirtablet800 mg/1oralCadila Pharmaceuticals Limited2012-03-08Not applicableUs
Acyclovirtablet800 mg/1oralAv Pak2014-07-18Not applicableUs
Acyclovirsuspension200 mg/5mLoralPhysicians Total Care, Inc.2006-10-03Not applicableUs
Acyclovirtablet800 mg/1oralMylan Pharmaceuticals Inc.2010-06-15Not applicableUs
Acyclovirtablet800 mg/1oralBlenheim Pharmacal, Inc.2013-12-10Not applicableUs
Acyclovirtablet400 mg/1oralCamber Pharmaceuticals, Inc.2013-11-29Not applicableUs
Acyclovircapsule200 mg/1oralPreferred Pharmaceuticals, Inc.2013-03-26Not applicableUs
Acyclovirtablet800 mg/1oralGolden State Medical Supply, Inc.1999-03-05Not applicableUs
Acyclovirinjection, solution50 mg/mLintravenousFresenius Kabi USA, LLC2000-10-17Not applicableUs
Acyclovirtablet400 mg/1oralMedsource Pharmaceuticals2014-09-10Not applicableUs
Acyclovircapsule200 mg/1oralProficient Rx LP1997-04-23Not applicableUs
Acyclovirtablet400 mg/1oralMajor Pharmaceuticals2007-02-09Not applicableUs
Acyclovirtablet800 mg/1oralStat Rx USA1998-09-30Not applicableUs
Acyclovirtablet400 mg/1oralAidarex Pharmaceuticals LLC1997-04-23Not applicableUs
Acyclovirtablet800 mg/1oralApotex Corp.2006-03-13Not applicableUs
Acyclovirtablet800 mg/1oralREMEDYREPACK INC.2016-04-04Not applicableUs
Acyclovirtablet400 mg/1oralREMEDYREPACK INC.2011-07-14Not applicableUs
Acyclovirtablet800 mg/1oralProficient Rx LP2013-11-29Not applicableUs
Acyclovirtablet400 mg/1oralMed Vantx, Inc.1997-04-23Not applicableUs
Acyclovirtablet800 mg/1oralNorthwind Pharmaceuticals2014-05-14Not applicableUs
Acyclovirtablet400 mg/1oralCardinal Health1999-03-05Not applicableUs
Acyclovircapsule200 mg/1oralPhysicians Total Care, Inc.1998-07-27Not applicableUs
Acyclovirtablet400 mg/1oralTeva Pharmaceuticals USA Inc1997-04-23Not applicableUs
Acyclovirtablet800 mg/1oralBlenheim Pharmacal, Inc.2010-07-20Not applicableUs
Acyclovircapsule200 mg/1oralHeritage Pharmaceuticals Inc.2014-06-02Not applicableUs
Acyclovirtablet400 mg/1oralPreferred Pharmaceuticals, Inc.2009-10-22Not applicableUs
Acyclovircapsule200 mg/1oralGolden State Medical Supply, Inc.2012-09-20Not applicableUs
Acyclovirinjection, powder, lyophilized, for solution500 mg/1intravenousWest Ward Pharmaceuticals Corp2016-02-29Not applicableUs
Acyclovirtablet400 mg/1oralPd Rx Pharmaceuticals, Inc.2009-10-22Not applicableUs
Acyclovirtablet400 mg/1oralDIRECT RX2014-01-01Not applicableUs
Acyclovirtablet400 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation2009-10-22Not applicableUs
Acyclovirtablet800 mg/1oralLake Erie Medical DBA Quality Care Products LLC2006-03-13Not applicableUs
Acyclovirtablet800 mg/1oralREMEDYREPACK INC.2011-09-20Not applicableUs
Acyclovirinjection, powder, lyophilized, for solution50 mg/mLintravenousAPP Pharmaceuticals, LLC2000-10-17Not applicableUs
Acyclovirtablet400 mg/1oralRed Pharm Drug Inc.2009-04-01Not applicableUs
Acyclovirtablet800 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Acyclovirtablet400 mg/1oralPd Rx Pharmaceuticals, Inc.2011-12-07Not applicableUs
Acyclovirtablet400 mg/1oralBlenheim Pharmacal, Inc.2011-03-02Not applicableUs
Acyclovirtablet400 mg/1oralRebel Distributors Corp1998-10-30Not applicableUs
Acyclovircapsule200 mg/1oralAv Kare, Inc.2013-07-08Not applicableUs
Acyclovirtablet400 mg/1oralGolden State Medical Supply, Inc.2012-09-21Not applicableUs
Acyclovircapsule200 mg/1oralREMEDYREPACK INC.2015-02-16Not applicableUs
Acyclovirsuspension200 mg/5mLoralPreferred Pharmaceuticals, Inc.2012-07-27Not applicableUs
Acyclovircapsule200 mg/1oralGolden State Medical Supply, Inc.1999-01-26Not applicableUs
Acyclovirtablet400 mg/1oralAmerican Health Packaging2014-01-29Not applicableUs
Acyclovirtablet800 mg/1oralREMEDYREPACK INC.2011-05-09Not applicableUs
Acyclovircapsule200 mg/1oralProficient Rx LP2009-10-22Not applicableUs
Acyclovircapsule200 mg/1oralCadila Pharmaceuticals Limited2014-03-11Not applicableUs
Acyclovirsuspension200 mg/5mLoralHi Tech Pharmacal Co., Inc.2005-06-07Not applicableUs
Acyclovirointment50 mg/gtopicalMylan Pharmaceuticals Inc.2013-04-03Not applicableUs
Acyclovirtablet400 mg/1oralBlenheim Pharmacal, Inc.2015-06-02Not applicableUs
Acyclovirtablet800 mg/1oralCamber Pharmaceuticals, Inc.2013-11-29Not applicableUs
Acyclovirtablet400 mg/1oralNorthwind Pharmaceuticals, LLC2014-10-22Not applicableUs
Acyclovircapsule200 mg/1oralCardinal Health2011-12-07Not applicableUs
Acyclovirtablet400 mg/1oralMajor Pharmaceuticals2010-06-14Not applicableUs
Acyclovirtablet400 mg/1oralStat Rx USA1998-09-30Not applicableUs
Acyclovirtablet400 mg/1oralRebel Distributors Corp2009-10-22Not applicableUs
Acyclovircapsule200 mg/1oralCarlsbad Technology, Inc.2009-10-22Not applicableUs
Acyclovircapsule200 mg/1oralREMEDYREPACK INC.2011-07-14Not applicableUs
Acyclovirtablet400 mg/1oralRanbaxy Laboratories Ltd.1999-02-08Not applicableUs
Acyclovircapsule200 mg/1oralDAVA Pharmaceuticals, Inc.1997-04-22Not applicableUs
Acyclovircapsule200 mg/1oralAv Pak2013-05-02Not applicableUs
Acyclovirtablet400 mg/1oralPhysicians Total Care, Inc.1998-11-17Not applicableUs
Acyclovirtablet800 mg/1oralTeva Pharmaceuticals USA Inc1997-04-30Not applicableUs
Acyclovircapsule200 mg/1oralBlenheim Pharmacal, Inc.2013-11-11Not applicableUs
Acyclovircapsule400 mg/1oralREMEDYREPACK INC.2013-02-27Not applicableUs
Acyclovirtablet800 mg/1oralPreferred Pharmaceuticals, Inc.2009-10-22Not applicableUs
Acyclovircapsule200 mg/1oralGolden State Medical Supply, Inc.1997-04-22Not applicableUs
Acyclovirinjection, powder, lyophilized, for solution1 g/1intravenousWest Ward Pharmaceuticals Corp2016-02-29Not applicableUs
Acyclovirtablet800 mg/1oralPd Rx Pharmaceuticals, Inc.2013-11-29Not applicableUs
Acyclovirtablet800 mg/1oralDIRECT RX2015-01-01Not applicableUs
Acyclovirointment50 mg/gtopicalAmneal Pharmaceuticals of New York, LLC2014-01-03Not applicableUs
Acyclovirtablet800 mg/1oralGolden State Medical Supply, Inc.2012-09-21Not applicableUs
Acyclovirtablet800 mg/1oralREMEDYREPACK INC.2015-07-27Not applicableUs
Acyclovircapsule200 mg/1oralREMEDYREPACK INC.2011-12-06Not applicableUs
Acyclovircapsule200 mg/1oralbryant ranch prepack1997-04-23Not applicableUs
Acyclovircapsule200 mg/1oralAmerican Health Packaging2014-01-29Not applicableUs
Acyclovirtablet400 mg/1oralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Acyclovirtablet800 mg/1oralPd Rx Pharmaceuticals, Inc.2011-12-07Not applicableUs
Acyclovircapsule200 mg/1oralBlenheim Pharmacal, Inc.2012-10-24Not applicableUs
Acyclovircapsule200 mg/1oralHeritage Pharmaceuticals, Inc.2010-06-14Not applicableUs
Acyclovirtablet400 mg/1oralAv Kare, Inc.1999-03-05Not applicableUs
Acyclovirtablet400 mg/1oralBlenheim Pharmacal, Inc.2015-09-02Not applicableUs
Acyclovirtablet800 mg/1oralAidarex Pharmaceuticals LLC1997-04-30Not applicableUs
Acyclovircapsule200 mg/1oralQuinn Pharmaceuticals, Llc2015-02-01Not applicableUs
Acyclovircapsule200 mg/1oralApotex Corp.2006-03-20Not applicableUs
Acyclovirtablet800 mg/1oralAmerican Health Packaging2014-01-29Not applicableUs
Acyclovircapsule200 mg/1oralREMEDYREPACK INC.2011-05-09Not applicableUs
Acyclovirtablet800 mg/1oralProficient Rx LP2006-03-13Not applicableUs
Acyclovirtablet400 mg/1oralCadila Healthcare Limited2014-09-10Not applicableUs
Acyclovirtablet400 mg/1oralUnit Dose Services2007-06-09Not applicableUs
Acyclovirsuspension200 mg/5mLoralActavis Mid Atlantic LLC2002-09-03Not applicableUs
Acyclovirtablet400 mg/1oralNorthwind Pharmaceuticals, LLC2015-03-03Not applicableUs
Acyclovirtablet200 mg/1oralCardinal Health1997-04-23Not applicableUs
Acyclovirtablet800 mg/1oralBlenheim Pharmacal, Inc.2010-11-08Not applicableUs
Acyclovirsuspension200 mg/5mLoralAtlantic Biologicals Corps2005-06-07Not applicableUs
Acyclovirtablet800 mg/1oralRebel Distributors Corp2009-10-22Not applicableUs
Acyclovirtablet400 mg/1oralREMEDYREPACK INC.2016-02-01Not applicableUs
Acyclovirtablet400 mg/1oralCarlsbad Technology, Inc.2009-10-22Not applicableUs
Acyclovirtablet400 mg/1oralREMEDYREPACK INC.2011-07-28Not applicableUs
Acyclovirtablet800 mg/1oralRanbaxy Laboratories Ltd.1999-02-08Not applicableUs
Acyclovirtablet400 mg/1oralDAVA Pharmaceuticals, Inc.1997-11-19Not applicableUs
Acyclovirtablet400 mg/1oralAv Pak1999-03-05Not applicableUs
Acyclovirtablet800 mg/1oralPhysicians Total Care, Inc.1998-11-17Not applicableUs
Acyclovirtablet400 mg/1oralMylan Pharmaceuticals Inc.2010-06-15Not applicableUs
Acyclovirtablet400 mg/1oralBlenheim Pharmacal, Inc.2013-09-30Not applicableUs
Acyclovirtablet400 mg/1oralREMEDYREPACK INC.2015-09-17Not applicableUs
Acyclovirsuspension200 mg/5mLoralPreferred Pharmaceuticals, Inc2011-03-18Not applicableUs
Acyclovirtablet400 mg/1oralGolden State Medical Supply, Inc.1999-03-05Not applicableUs
Acyclovirtablet400 mg/1oralLake Erie Medical DBA Quality Care Products LLC2012-09-21Not applicableUs
Acyclovirtablet800 mg/1oralAphena Pharma Solutions Tennessee, Llc2012-09-21Not applicableUs
Acyclovirtablet400 mg/1oralDIRECT RX2015-01-01Not applicableUs
Acyclovirtablet400 mg/1oralCadila Pharmaceuticals Limited2012-03-07Not applicableUs
Acyclovirtablet400 mg/1oralHeritage Pharmaceuticals Inc.2013-08-08Not applicableUs
Acyclovirtablet800 mg/1oralAv Kare, Inc.1999-03-05Not applicableUs
Acyclovircapsule200 mg/1oralCardinal Health2007-04-19Not applicableUs
Acyclovirtablet400 mg/1oralREMEDYREPACK INC.2015-12-10Not applicableUs
Acyclovirtablet800 mg/1oralREMEDYREPACK INC.2011-05-16Not applicableUs
Acyclovirtablet400 mg/1oralbryant ranch prepack2011-05-27Not applicableUs
Acyclovirtablet400 mg/1oralZydus Pharmaceuticals (USA) Inc.2014-09-10Not applicableUs
Acyclovirtablet400 mg/1oralState of Florida DOH Central Pharmacy2013-12-01Not applicableUs
Acyclovirtablet400 mg/1oralClinical Solutions Wholesale1997-04-23Not applicableUs
Acyclovircapsule200 mg/1oralBlenheim Pharmacal, Inc.2011-02-15Not applicableUs
Acyclovir Sodiuminjection, solution500 mg/10mLintravenousAuro Medics Pharma Llc2013-10-11Not applicableUs
Acyclovir Sodiuminjection, solution1000 mg/20mLintravenousAuro Medics Pharma Llc2013-10-11Not applicableUs
Apo-acyclovir - Tab 200mgtablet200 mgoralApotex Inc1997-08-22Not applicableCanada
Apo-acyclovir - Tab 400mgtablet400 mgoralApotex Inc1997-08-22Not applicableCanada
Apo-acyclovir - Tab 800mgtablet800 mgoralApotex Inc1997-08-22Not applicableCanada
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ZovirNot Available
Brand mixtures
NameLabellerIngredients
XereseValeant Pharmaceuticals North America LLC
Salts
Name/CASStructureProperties
Aciclovir Sodium
69657-51-8
Thumb
  • InChI Key:
  • Monoisotopic Mass:
  • Average Mass:
DBSALT000004
Categories
UNIIX4HES1O11F
CAS number59277-89-3
WeightAverage: 225.2046
Monoisotopic: 225.086189243
Chemical FormulaC8H11N5O3
InChI KeyInChIKey=MKUXAQIIEYXACX-UHFFFAOYSA-N
InChI
InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
IUPAC Name
2-amino-9-[(2-hydroxyethoxy)methyl]-6,9-dihydro-3H-purin-6-one
SMILES
NC1=NC(=O)C2=C(N1)N(COCCO)C=N2
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as hypoxanthines. These are compounds containing the purine derivative 1H-purin-6(9H)-one. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassImidazopyrimidines
Sub ClassPurines and purine derivatives
Direct ParentHypoxanthines
Alternative Parents
Substituents
  • Hypoxanthine
  • 6-oxopurine
  • Pyrimidone
  • Pyrimidine
  • Primary aromatic amine
  • N-substituted imidazole
  • Heteroaromatic compound
  • Vinylogous amide
  • Imidazole
  • Azole
  • Azacycle
  • Hydrocarbon derivative
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Pharmacology
IndicationFor the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.
PharmacodynamicsAciclovir (INN) or acyclovir (USAN, former BAN) is a synthetic deoxyguanosine analog and it is the prototype antiviral agent that is activated by viral thymidine kinase. The selective activity of aciclovir is due to its affinity for the thymidine kinase enzyme encoded by HSV and VZV. EC50 value of acyclovir against clinical herpes virus isolates was 1.3 μM (range: < 0.56 to 3.3 μM).
Mechanism of actionViral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir to the aciclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator. One may consider aciclovir to be a prodrug as it is metabolized to more active compounds. Aciclovir is selective and low in cytotoxicity as the cellular thymidine kinase of normal, uninfected cells does not use aciclovir effectively as a substrate.
Related Articles
AbsorptionThe oral bioavailability is 10% to 20%, and decreases with increasing dose. Food does not affect the absorption of acyclovir. The following are the pharmacokinetic parameters for 50 mg buccal tablet, Sitavig, in the saliva: AUC 0 - 24 hours = 2900±2400 mcg.h/mL; Cmax = 440±241 mcg/mL; Tmax = 7.95 ± 4.08 hours.
Volume of distributionNot Available
Protein binding9%-33%
Metabolism

Hepatic, Acyclovir is metabolized to 9-[(carboxymethoxy)methyl]guanine (CMMG) and 8­ hydroxy-acyclovir (8-OH-ACV) by oxidation and hydroxylation. It is suggested in studies that acyclovir is first metabolized to acyclovir aldehyde by alcohol dehydrogenase and then converted to CMMG. The build up of acyclovir aldehyde may be the cause of acyclovir-induced nephrotoxicity in the absence of crystalluria.

SubstrateEnzymesProduct
Aciclovir
Not Available
9-carboxymethoxymethylguanineDetails
Route of eliminationPrimarily excreted unchanged by the kidneys via active tubular secretion.
Half life2.5-3.3 hours
ClearanceNot Available
ToxicityAciclovir may cause nephrotoxicity (crystallization of aciclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of aciclovir therapy. However, there is no well-defined relationship between aciclovir concentrations in the blood and these adverse effects.
Affected organisms
  • Human Herpes Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Actavis elizabeth llc
  • Apotex inc etobicoke site
  • Belcher pharmaceuticals inc
  • Dava pharmaceuticals inc
  • Genpharm inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • Lek pharmaceutical and chemical co dd
  • Mylan pharmaceuticals inc
  • Ranbaxy laboratories ltd
  • Roxane laboratories inc
  • Stason industrial corp
  • Teva pharmaceuticals usa inc
  • Teva pharmaceuticals usa
  • Watson laboratories inc
  • Glaxosmithkline
  • Actavis mid atlantic llc
  • Hi tech pharmacal co inc
  • Carlsbad technology inc
  • Mylan laboratories inc
  • Abbott laboratories
  • Baxter healthcare corp anesthesia and critical care
  • Apothecon inc div bristol myers squibb
  • App pharmaceuticals llc
  • Bedford laboratories div ben venue laboratories inc
  • Hospira inc
  • Teva parenteral medicines inc
Packagers
Dosage forms
FormRouteStrength
Capsuleoral200 mg/1
Capsuleoral400 mg/1
Injection, powder, lyophilized, for solutionintravenous1 g/1
Injection, powder, lyophilized, for solutionintravenous50 mg/mL
Injection, powder, lyophilized, for solutionintravenous500 mg/1
Injection, solutionintravenous50 mg/mL
Suspensionoral200 mg/5mL
Tabletoral200 mg/1
Tabletoral400 mg/1
Tabletoral800 mg/1
Injection, solutionintravenous1000 mg/20mL
Injection, solutionintravenous500 mg/10mL
Powder for solutionintravenous500 mg
Solutionintravenous25 mg
Solutionintravenous50 mg
Tabletoral200 mg
Tabletoral400 mg
Tabletoral800 mg
Tablet, delayed releasebuccal50 mg/1
Creamtopical
Creamtopical5 %
Creamtopical50 mg/g
Ointmenttopical5 %
Ointmenttopical50 mg/g
Powder for solutionintravenous1 g
Suspensionoral200 mg
Capsuleoral200 mg
Prices
Unit descriptionCostUnit
Zovirax 200 mg/5ml Suspension 473ml Bottle264.95USD bottle
Zovirax 5% Ointment 15 gm Tube191.56USD tube
Zovirax 5% Cream 5 gm Tube165.07USD tube
Zovirax 5% Cream 2 gm Tube69.44USD tube
Zovirax 5% cream30.22USD g
Zovirax 800 mg tablet11.83USD tablet
Zovirax 400 mg tablet6.09USD tablet
Zovirax 800 mg Tablet5.71USD tablet
Acyclovir 800 mg tablet3.81USD tablet
Zovirax 200 mg capsule3.08USD capsule
Acyclovir 800 mg Tablet2.99USD tablet
Apo-Acyclovir 800 mg Tablet2.99USD tablet
Mylan-Acyclovir 800 mg Tablet2.99USD tablet
Novo-Acyclovir 800 mg Tablet2.99USD tablet
Nu-Acyclovir 800 mg Tablet2.99USD tablet
Ratio-Acyclovir 800 mg Tablet2.99USD tablet
Zovirax 400 mg Tablet2.9USD tablet
Acyclovir 400 mg tablet2.26USD tablet
Acyclovir 400 mg Tablet1.63USD tablet
Apo-Acyclovir 400 mg Tablet1.63USD tablet
Mylan-Acyclovir 400 mg Tablet1.63USD tablet
Novo-Acyclovir 400 mg Tablet1.63USD tablet
Nu-Acyclovir 400 mg Tablet1.63USD tablet
Ratio-Acyclovir 400 mg Tablet1.63USD tablet
Zovirax 200 mg Tablet1.44USD tablet
Acyclovir 200 mg capsule1.01USD capsule
Acyclovir 200 mg Tablet0.81USD tablet
Apo-Acyclovir 200 mg Tablet0.81USD tablet
Mylan-Acyclovir 200 mg Tablet0.81USD tablet
Novo-Acyclovir 200 mg Tablet0.81USD tablet
Ratio-Acyclovir 200 mg Tablet0.81USD tablet
Acyclovir 200 mg/5ml Suspension0.3USD ml
Zovirax 40 mg/ml Suspension0.28USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2098108 No2001-07-032012-01-29Canada
US6514980 No1999-01-242019-01-24Us
US7223387 No2001-07-242021-07-24Us
US8592434 No2010-06-162030-06-16Us
US8747896 No2007-06-032027-06-03Us
US8791127 No2007-03-232027-03-23Us
USRE39264 No1996-08-022016-08-02Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point255 °CPhysProp
water solubility2.5 mg/mL at 37°CFDA label
logP-1.56KRISTL,A ET AL. (1993)
Caco2 permeability-6.15ADME Research, USCD
pKa2.27 and 9.25 FDA label
Predicted Properties
PropertyValueSource
Water Solubility9.08 mg/mLALOGPS
logP-0.95ALOGPS
logP-1ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)7.99ChemAxon
pKa (Strongest Basic)2.63ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area114.76 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity54.63 m3·mol-1ChemAxon
Polarizability21.51 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
References
Synthesis Reference

DrugSyn.org

US4294831
General References
  1. O'Brien JJ, Campoli-Richards DM: Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1989 Mar;37(3):233-309. [PubMed:2653790 ]
  2. Gunness P, Aleksa K, Bend J, Koren G: Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite. Transl Res. 2011 Nov;158(5):290-301. doi: 10.1016/j.trsl.2011.07.002. Epub 2011 Aug 3. [PubMed:22005269 ]
  3. Morrel EM, Spruance SL, Goldberg DI: Topical iontophoretic administration of acyclovir for the episodic treatment of herpes labialis: a randomized, double-blind, placebo-controlled, clinic-initiated trial. Clin Infect Dis. 2006 Aug 15;43(4):460-7. Epub 2006 Jul 3. [PubMed:16838235 ]
External Links
ATC CodesS01AD03D06BB53J05AB01D06BB03
AHFS Codes
  • 08:18.32
  • 84:04.06
PDB Entries
FDA labelNot Available
MSDSDownload (37 KB)
Interactions
Drug Interactions
Drug
TeriflunomideThe serum concentration of Aciclovir can be increased when it is combined with Teriflunomide.
Food Interactions
  • Increase liquid intake.
  • Take without regard to meals.

Targets

Kind
Protein
Organism
HHV-1
Pharmacological action
yes
Actions
inhibitor
General Function:
Rna-dna hybrid ribonuclease activity
Specific Function:
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefo...
Gene Name:
Not Available
Uniprot ID:
P04293
Molecular Weight:
136419.66 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Sergerie Y, Boivin G: Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes. Antiviral Res. 2008 Jan;77(1):77-80. Epub 2007 Sep 17. [PubMed:17913252 ]
  4. Suzuki M, Okuda T, Shiraki K: Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. Epub 2006 May 30. [PubMed:16797734 ]
  5. Liu S, Knafels JD, Chang JS, Waszak GA, Baldwin ET, Deibel MR Jr, Thomsen DR, Homa FL, Wells PA, Tory MC, Poorman RA, Gao H, Qiu X, Seddon AP: Crystal structure of the herpes simplex virus 1 DNA polymerase. J Biol Chem. 2006 Jun 30;281(26):18193-200. Epub 2006 Apr 24. [PubMed:16638752 ]
Kind
Protein
Organism
HHV-3
Pharmacological action
yes
Actions
inhibitor
General Function:
Rna-dna hybrid ribonuclease activity
Specific Function:
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefo...
Gene Name:
Not Available
Uniprot ID:
P09252
Molecular Weight:
134046.615 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Sergerie Y, Boivin G: Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes. Antiviral Res. 2008 Jan;77(1):77-80. Epub 2007 Sep 17. [PubMed:17913252 ]
  4. Suzuki M, Okuda T, Shiraki K: Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. Epub 2006 May 30. [PubMed:16797734 ]
  5. Liu S, Knafels JD, Chang JS, Waszak GA, Baldwin ET, Deibel MR Jr, Thomsen DR, Homa FL, Wells PA, Tory MC, Poorman RA, Gao H, Qiu X, Seddon AP: Crystal structure of the herpes simplex virus 1 DNA polymerase. J Biol Chem. 2006 Jun 30;281(26):18193-200. Epub 2006 Apr 24. [PubMed:16638752 ]
Kind
Protein
Organism
HHV-1
Pharmacological action
yes
Actions
potentiator
General Function:
Thymidine kinase activity
Specific Function:
In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.
Gene Name:
TK
Uniprot ID:
P03176
Molecular Weight:
40971.555 Da
References
  1. Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR: Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir. FEBS Lett. 1999 Jan 25;443(2):121-5. [PubMed:9989588 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. [PubMed:11861798 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-in...
Gene Name:
SLC22A6
Uniprot ID:
Q4U2R8
Molecular Weight:
61815.78 Da
References
  1. Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. [PubMed:11861798 ]
  2. Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H: Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. [PubMed:10945832 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. [PubMed:11861798 ]
  2. Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T: Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002 Oct;83(1):57-66. [PubMed:12358729 ]
  3. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. [PubMed:11306713 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Bile acid:sodium symporter activity
Specific Function:
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.
Gene Name:
SLC10A2
Uniprot ID:
Q12908
Molecular Weight:
37713.405 Da
References
  1. Tolle-Sander S, Lentz KA, Maeda DY, Coop A, Polli JE: Increased acyclovir oral bioavailability via a bile acid conjugate. Mol Pharm. 2004 Jan 12;1(1):40-8. [PubMed:15832499 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Monovalent cation:proton antiporter activity
Specific Function:
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport...
Gene Name:
SLC47A1
Uniprot ID:
Q96FL8
Molecular Weight:
61921.585 Da
References
  1. Nies AT, Damme K, Schaeffeler E, Schwab M: Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs. Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1565-77. doi: 10.1517/17425255.2012.722996. Epub 2012 Sep 13. [PubMed:22970772 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Drug transmembrane transporter activity
Specific Function:
Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.
Gene Name:
SLC47A2
Uniprot ID:
Q86VL8
Molecular Weight:
65083.915 Da
References
  1. Nies AT, Damme K, Schaeffeler E, Schwab M: Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs. Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1565-77. doi: 10.1517/17425255.2012.722996. Epub 2012 Sep 13. [PubMed:22970772 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on October 01, 2016 02:24