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Identification
NameEdoxaban
Accession NumberDB09075
TypeSmall Molecule
GroupsApproved
Description

Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF) and for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5-10 days of initial therapy with a parenteral anticoagulant. Traditionally, warfarin, a vitamin K antagonist, was used for stroke prevention in these individuals but effective use of this drug is limited by it’s delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions. This has prompted enthusiasm for newer agents such as dabigatran, apixaban, and rivaroxaban for effective clot prevention. In addition to once daily dosing, the benefits over warfarin also include significant reductions in hemorrhagic stroke and GI bleeding, and improved compliance, which is beneficial as many patients will be on lifelong therapy.

Structure
Thumb
SynonymsNot Available
External Identifiers
  • DU 176
  • DU 176b
  • DU-176
  • DU-176b
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Savaysatablet, film coated15 mg/1oralDaiichi Sankyo, Inc.2015-01-12Not applicableUs
Savaysatablet, film coated60 mg/1oralDaiichi Sankyo, Inc.2015-01-12Not applicableUs
Savaysatablet, film coated30 mg/1oralDaiichi Sankyo, Inc.2015-01-12Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
LixianaDaiichi-Sankyo
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Edoxaban tosylate
480449-71-6
ThumbNot applicableDBSALT001717
Edoxaban tosylate monohydrate
1229194-11-9
ThumbNot applicableDBSALT001718
Categories
UNIINDU3J18APO
CAS number480449-70-5
WeightAverage: 548.06
Monoisotopic: 547.1768513
Chemical FormulaC24H30ClN7O4S
InChI KeyHGVDHZBSSITLCT-JLJPHGGASA-N
InChI
InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1
IUPAC Name
N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-amido}cyclohexyl]ethanediamide
SMILES
CN(C)C(=O)[[email protected]]1CC[[email protected]](NC(=O)C(=O)NC2=NC=C(Cl)C=C2)[C@@H](C1)NC(=O)C1=NC2=C(CN(C)CC2)S1
Taxonomy
ClassificationNot classified
Pharmacology
IndicationEdoxaban is indicated to reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF). However, it should not be used in patients with creatinine clearance (CrCL) > 95 mL/min because of increased risk of ischemic stroke compared to warfarin at the highest dose studied (60 mg). It is also indicated for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5-10 days of initial therapy with a parenteral anticoagulant.
PharmacodynamicsAdministration of edoxaban results in prolongation of clotting time tests such as aPTT (activated partial thromboplastin time), PT (prothrombin time), and INR (international normalized ratio).
Mechanism of actionEdoxaban is a selective inhibitor of factor Xa, a serine endopeptidase of the clotting cascade required for cleavage of prothrombin into thrombin.
Related Articles
AbsorptionFollowing oral administration, peak plasma edoxaban concentrations are observed within 1-2 hours. Absolute bioavailability is 62%.
Volume of distribution

The steady state volume of distribution is 107 L.

Protein bindingIn vitro plasma protein binding is ~55%.
Metabolism

Edoxaban is not extensively metabolized by CYP3A4 resulting in minimal drug-drug interactions. However, it does interact with drugs that inhibit p-gp (p-glycoprotein), which is used to transport edoxaban across the intestinal wall. Unchanged edoxaban is the predominant form in plasma. There is minimal metabolism via hydrolysis (mediated by carboxylesterase 1), conjugation, and oxidation by CYP3A4. The predominant metabolite M-4, formed by hydrolysis, is human-specific and active and reaches less than 10% of the exposure of the parent compound in healthy subjects. Exposure to the other metabolites is less than 5% of exposure to edoxaban.

Route of eliminationEdoxaban is eliminated primarily as unchanged drug in urine. Renal clearance (11 L/hour) accounts for approximately 50% of the total clearance of edoxaban (22 L/hour). Metabolism and biliary/intestinal excretion account for the remaining clearance.
Half lifeThe terminal elimination half-life of edoxaban following oral administration is 10 to 14 hours.
Clearance

22 L/hr

ToxicityPremature discontinuation of any oral anticoagulant, including edoxaban, in the absence of adequate alternative anticoagulation increases the risk of ischemic events. If edoxaban is discontinued for reasons other than pathological bleeding or completion of a course of therapy, consider the use of another anticoagulant. Edoxaban increases the risk of potentially fatal major bleeding such as intracranial hemorrhage and gastrointestinal bleeding. Patients should be educated on how to watch for signs of major and minor bleeding and when to seek medical help. Co-administration of other anti-coagulants, anti-platelets, or thrombolytics may increase the risk of bleeding and should therefore be avoided.
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal AbsorptionNot AvailableNot Available
Blood Brain BarrierNot AvailableNot Available
Caco-2 permeableNot AvailableNot Available
P-glycoprotein substrateNot AvailableNot Available
P-glycoprotein inhibitor INot AvailableNot Available
P-glycoprotein inhibitor IINot AvailableNot Available
Renal organic cation transporterNot AvailableNot Available
CYP450 2C9 substrateNot AvailableNot Available
CYP450 2D6 substrateNot AvailableNot Available
CYP450 3A4 substrateNot AvailableNot Available
CYP450 1A2 substrateNot AvailableNot Available
CYP450 2C9 inhibitorNot AvailableNot Available
CYP450 2D6 inhibitorNot AvailableNot Available
CYP450 2C19 inhibitorNot AvailableNot Available
CYP450 3A4 inhibitorNot AvailableNot Available
CYP450 inhibitory promiscuityNot AvailableNot Available
Ames testNot AvailableNot Available
CarcinogenicityNot AvailableNot Available
BiodegradationNot AvailableNot Available
Rat acute toxicityNot AvailableNot applicable
hERG inhibition (predictor I)Not AvailableNot Available
hERG inhibition (predictor II)Not AvailableNot Available
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Tablet, film coatedoral15 mg/1
Tablet, film coatedoral30 mg/1
Tablet, film coatedoral60 mg/1
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US2013026553 No2011-08-222031-08-22Us
US7365205 No2003-06-122023-06-12Us
US9149532 No2008-03-282028-03-28Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
pKa6.7FDA Label
Predicted Properties
PropertyValueSource
Water Solubility0.0114 mg/mLALOGPS
logP1.61ALOGPS
logP0.9ChemAxon
logS-4.7ALOGPS
pKa (Strongest Acidic)10.74ChemAxon
pKa (Strongest Basic)6.33ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area136.63 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity140.14 m3·mol-1ChemAxon
Polarizability56.31 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis ReferenceNot Available
General References
  1. Turpie AG: New oral anticoagulants in atrial fibrillation. Eur Heart J. 2008 Jan;29(2):155-65. Epub 2007 Dec 19. [PubMed:18096568 ]
  2. Ogata K, Mendell-Harary J, Tachibana M, Masumoto H, Oguma T, Kojima M, Kunitada S: Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers. J Clin Pharmacol. 2010 Jul;50(7):743-53. doi: 10.1177/0091270009351883. Epub 2010 Jan 15. [PubMed:20081065 ]
  3. Yeh CH, Hogg K, Weitz JI: Overview of the new oral anticoagulants: opportunities and challenges. Arterioscler Thromb Vasc Biol. 2015 May;35(5):1056-65. doi: 10.1161/ATVBAHA.115.303397. Epub 2015 Mar 19. [PubMed:25792448 ]
  4. Senoo K, Lip GY: Comparative efficacy and safety of the non-vitamin K antagonist oral anticoagulants for patients with nonvalvular atrial fibrillation. Semin Thromb Hemost. 2015 Mar;41(2):146-53. doi: 10.1055/s-0035-1544156. Epub 2015 Feb 15. [PubMed:25682085 ]
  5. Parasrampuria DA, Truitt KE: Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting Factor Xa. Clin Pharmacokinet. 2015 Nov 30. [PubMed:26620048 ]
External Links
ATC CodesNot Available
AHFS Codes
  • 20:12.04.14
PDB EntriesNot Available
FDA labelDownload (600 KB)
MSDSNot Available
Interactions
Drug Interactions
Drug
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Edoxaban.
AbciximabEdoxaban may increase the anticoagulant activities of Abciximab.
AceclofenacAceclofenac may increase the anticoagulant activities of Edoxaban.
AcenocoumarolEdoxaban may increase the anticoagulant activities of Acenocoumarol.
AcetaminophenThe serum concentration of Edoxaban can be increased when it is combined with Acetaminophen.
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Edoxaban.
AdapaleneAdapalene may increase the anticoagulant activities of Edoxaban.
AfatinibThe serum concentration of Edoxaban can be increased when it is combined with Afatinib.
AlbendazoleThe serum concentration of Edoxaban can be increased when it is combined with Albendazole.
AldosteroneThe serum concentration of Edoxaban can be decreased when it is combined with Aldosterone.
AlectinibThe serum concentration of Edoxaban can be increased when it is combined with Alectinib.
AlfentanilThe serum concentration of Edoxaban can be increased when it is combined with Alfentanil.
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Edoxaban.
AllylestrenolThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Allylestrenol.
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Edoxaban.
AlprostadilAlprostadil may increase the anticoagulant activities of Edoxaban.
AlteplaseAlteplase may increase the anticoagulant activities of Edoxaban.
AltrenogestThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Altrenogest.
ALX-0081ALX-0081 may increase the anticoagulant activities of Edoxaban.
AmantadineThe serum concentration of Edoxaban can be increased when it is combined with Amantadine.
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Edoxaban.
Aminohippuric acidThe serum concentration of Edoxaban can be increased when it is combined with Aminohippuric acid.
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Edoxaban.
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Edoxaban.
AmiodaroneThe serum concentration of Edoxaban can be decreased when it is combined with Amiodarone.
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Edoxaban.
AmlodipineThe serum concentration of Edoxaban can be increased when it is combined with Amlodipine.
AmprenavirThe serum concentration of Edoxaban can be decreased when it is combined with Amprenavir.
AmsacrineThe serum concentration of Edoxaban can be increased when it is combined with Amsacrine.
AnagrelideAnagrelide may increase the anticoagulant activities of Edoxaban.
AncrodEdoxaban may increase the anticoagulant activities of Ancrod.
AnistreplaseAnistreplase may increase the anticoagulant activities of Edoxaban.
AntipyrineAntipyrine may increase the anticoagulant activities of Edoxaban.
Antithrombin III humanEdoxaban may increase the anticoagulant activities of Antithrombin III human.
ApixabanApixaban may increase the anticoagulant activities of Edoxaban.
ApremilastApremilast may increase the anticoagulant activities of Edoxaban.
ArdeparinEdoxaban may increase the anticoagulant activities of Ardeparin.
ArgatrobanEdoxaban may increase the anticoagulant activities of Argatroban.
AstaxanthinAstaxanthin may increase the anticoagulant activities of Edoxaban.
AstemizoleThe serum concentration of Edoxaban can be increased when it is combined with Astemizole.
AtazanavirThe serum concentration of Edoxaban can be increased when it is combined with Atazanavir.
AtenololThe serum concentration of Edoxaban can be increased when it is combined with Atenolol.
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Edoxaban.
AzapropazoneAzapropazone may increase the anticoagulant activities of Edoxaban.
AzelastineAzelastine may increase the anticoagulant activities of Edoxaban.
AzithromycinThe serum concentration of Edoxaban can be increased when it is combined with Azithromycin.
BalsalazideBalsalazide may increase the anticoagulant activities of Edoxaban.
BatroxobinBatroxobin may increase the anticoagulant activities of Edoxaban.
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Edoxaban.
BecaplerminEdoxaban may increase the anticoagulant activities of Becaplermin.
BemiparinBemiparin may increase the anticoagulant activities of Edoxaban.
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Edoxaban.
BenzocaineThe serum concentration of Edoxaban can be increased when it is combined with Benzocaine.
BepridilThe serum concentration of Edoxaban can be increased when it is combined with Bepridil.
BeraprostBeraprost may increase the anticoagulant activities of Edoxaban.
BiperidenThe serum concentration of Edoxaban can be increased when it is combined with Biperiden.
BivalirudinEdoxaban may increase the anticoagulant activities of Bivalirudin.
BoceprevirThe serum concentration of Edoxaban can be decreased when it is combined with Boceprevir.
BosutinibThe serum concentration of Edoxaban can be increased when it is combined with Bosutinib.
BromfenacBromfenac may increase the anticoagulant activities of Edoxaban.
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Edoxaban.
BuprenorphineThe serum concentration of Edoxaban can be increased when it is combined with Buprenorphine.
BuspironeThe serum concentration of Edoxaban can be increased when it is combined with Buspirone.
CabazitaxelThe serum concentration of Edoxaban can be increased when it is combined with Cabazitaxel.
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Edoxaban.
CaffeineThe serum concentration of Edoxaban can be increased when it is combined with Caffeine.
CanagliflozinThe serum concentration of Edoxaban can be increased when it is combined with Canagliflozin.
CandesartanThe serum concentration of Edoxaban can be increased when it is combined with Candesartan.
CangrelorCangrelor may increase the anticoagulant activities of Edoxaban.
CaptoprilThe serum concentration of Edoxaban can be increased when it is combined with Captopril.
CarbamazepineThe serum concentration of Edoxaban can be decreased when it is combined with Carbamazepine.
CarprofenCarprofen may increase the anticoagulant activities of Edoxaban.
CarvedilolThe serum concentration of Edoxaban can be increased when it is combined with Carvedilol.
CaspofunginThe serum concentration of Edoxaban can be increased when it is combined with Caspofungin.
CastanospermineCastanospermine may increase the anticoagulant activities of Edoxaban.
CelecoxibCelecoxib may increase the anticoagulant activities of Edoxaban.
CertoparinEdoxaban may increase the anticoagulant activities of Certoparin.
ChloroquineChloroquine may increase the anticoagulant activities of Edoxaban.
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Edoxaban.
ChlorpromazineThe serum concentration of Edoxaban can be increased when it is combined with Chlorpromazine.
ChlorpropamideThe serum concentration of Edoxaban can be increased when it is combined with Chlorpropamide.
ChlorprothixeneThe serum concentration of Edoxaban can be increased when it is combined with Chlorprothixene.
CholesterolThe serum concentration of Edoxaban can be increased when it is combined with Cholesterol.
Cholic AcidThe serum concentration of Edoxaban can be decreased when it is combined with Cholic Acid.
CilazaprilThe serum concentration of Edoxaban can be increased when it is combined with Cilazapril.
CilostazolCilostazol may increase the anticoagulant activities of Edoxaban.
CimetidineThe serum concentration of Edoxaban can be decreased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Edoxaban can be increased when it is combined with Ciprofloxacin.
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Edoxaban.
CitalopramThe serum concentration of Edoxaban can be increased when it is combined with Citalopram.
Citric AcidEdoxaban may increase the anticoagulant activities of Citric Acid.
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Edoxaban.
ClarithromycinThe serum concentration of Edoxaban can be increased when it is combined with Clarithromycin.
ClofazimineThe serum concentration of Edoxaban can be increased when it is combined with Clofazimine.
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Edoxaban.
ClonixinClonixin may increase the anticoagulant activities of Edoxaban.
ClopidogrelClopidogrel may increase the anticoagulant activities of Edoxaban.
ClotrimazoleThe serum concentration of Edoxaban can be decreased when it is combined with Clotrimazole.
CobicistatThe serum concentration of Edoxaban can be increased when it is combined with Cobicistat.
ColchicineThe serum concentration of Edoxaban can be increased when it is combined with Colchicine.
ColforsinThe serum concentration of Edoxaban can be increased when it is combined with Colforsin.
CollagenaseThe risk or severity of adverse effects can be increased when Edoxaban is combined with Collagenase.
Conjugated Equine EstrogensConjugated Equine Estrogens may decrease the anticoagulant activities of Edoxaban.
CrizotinibThe serum concentration of Edoxaban can be increased when it is combined with Crizotinib.
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Edoxaban.
CyclophosphamideThe risk or severity of adverse effects can be increased when Edoxaban is combined with Cyclophosphamide.
CyclophosphamideThe serum concentration of Edoxaban can be increased when it is combined with Cyclophosphamide.
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Edoxaban.
CyclosporineThe serum concentration of Edoxaban can be decreased when it is combined with Cyclosporine.
D-LimoneneD-Limonene may increase the anticoagulant activities of Edoxaban.
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Edoxaban.
DaclatasvirThe serum concentration of Edoxaban can be increased when it is combined with Daclatasvir.
DactinomycinThe serum concentration of Edoxaban can be increased when it is combined with Dactinomycin.
DalteparinEdoxaban may increase the anticoagulant activities of Dalteparin.
DanaparoidEdoxaban may increase the anticoagulant activities of Danaparoid.
DasatinibDasatinib may increase the anticoagulant activities of Edoxaban.
DaunorubicinThe serum concentration of Edoxaban can be decreased when it is combined with Daunorubicin.
DeferasiroxThe risk or severity of adverse effects can be increased when Edoxaban is combined with Deferasirox.
DefibrotideDefibrotide may increase the anticoagulant activities of Edoxaban.
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Edoxaban.
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Edoxaban is combined with Deoxycholic Acid.
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Edoxaban.
DesirudinEdoxaban may increase the anticoagulant activities of Desirudin.
DesloratadineThe serum concentration of Edoxaban can be increased when it is combined with Desloratadine.
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Edoxaban.
DesogestrelThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Desogestrel.
DexamethasoneThe serum concentration of Edoxaban can be decreased when it is combined with Dexamethasone.
DextranEdoxaban may increase the anticoagulant activities of Dextran.
Dextran 40Edoxaban may increase the anticoagulant activities of Dextran 40.
Dextran 70Edoxaban may increase the anticoagulant activities of Dextran 70.
Dextran 75Edoxaban may increase the anticoagulant activities of Dextran 75.
DextromethorphanThe serum concentration of Edoxaban can be increased when it is combined with Dextromethorphan.
DiclofenacDiclofenac may increase the anticoagulant activities of Edoxaban.
DicoumarolEdoxaban may increase the anticoagulant activities of Dicoumarol.
DienestrolDienestrol may decrease the anticoagulant activities of Edoxaban.
DienogestThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Dienogest.
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Edoxaban.
DiflunisalDiflunisal may increase the anticoagulant activities of Edoxaban.
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Edoxaban.
DigoxinThe serum concentration of Edoxaban can be decreased when it is combined with Digoxin.
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Edoxaban.
DiltiazemThe serum concentration of Edoxaban can be increased when it is combined with Diltiazem.
DipyridamoleDipyridamole may increase the anticoagulant activities of Edoxaban.
DitazoleDitazole may increase the anticoagulant activities of Edoxaban.
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Edoxaban.
DoxazosinThe serum concentration of Edoxaban can be increased when it is combined with Doxazosin.
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Edoxaban.
DoxorubicinThe serum concentration of Edoxaban can be decreased when it is combined with Doxorubicin.
DronabinolThe serum concentration of Edoxaban can be increased when it is combined with Dronabinol.
DronedaroneThe serum concentration of Edoxaban can be increased when it is combined with Dronedarone.
DrospirenoneThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Drospirenone.
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Edoxaban.
DroxicamDroxicam may increase the anticoagulant activities of Edoxaban.
DydrogesteroneThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Dydrogesterone.
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Edoxaban.
Edetic AcidEdoxaban may increase the anticoagulant activities of Edetic Acid.
ElbasvirThe serum concentration of Edoxaban can be increased when it is combined with Elbasvir.
EnalaprilThe serum concentration of Edoxaban can be increased when it is combined with Enalapril.
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Edoxaban.
EnoxaparinEdoxaban may increase the anticoagulant activities of Enoxaparin.
EnzalutamideThe serum concentration of Edoxaban can be increased when it is combined with Enzalutamide.
EpinastineEpinastine may increase the anticoagulant activities of Edoxaban.
EpirizoleEpirizole may increase the anticoagulant activities of Edoxaban.
EpoprostenolEpoprostenol may increase the anticoagulant activities of Edoxaban.
EptifibatideEptifibatide may increase the anticoagulant activities of Edoxaban.
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Edoxaban.
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Edoxaban.
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Edoxaban.
ErythromycinThe serum concentration of Edoxaban can be decreased when it is combined with Erythromycin.
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Edoxaban.
EstradiolEstradiol may decrease the anticoagulant activities of Edoxaban.
EstramustineThe serum concentration of Edoxaban can be increased when it is combined with Estramustine.
EstriolThe serum concentration of Edoxaban can be decreased when it is combined with Estriol.
EstroneThe serum concentration of Edoxaban can be decreased when it is combined with Estrone.
EtanerceptEtanercept may increase the anticoagulant activities of Edoxaban.
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Edoxaban.
Ethyl biscoumacetateEdoxaban may increase the anticoagulant activities of Ethyl biscoumacetate.
EtodolacEtodolac may increase the anticoagulant activities of Edoxaban.
EtofenamateEtofenamate may increase the anticoagulant activities of Edoxaban.
EtonogestrelThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Etonogestrel.
EtoposideThe serum concentration of Edoxaban can be increased when it is combined with Etoposide.
EtoricoxibEtoricoxib may increase the anticoagulant activities of Edoxaban.
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Edoxaban.
EtravirineThe serum concentration of Edoxaban can be increased when it is combined with Etravirine.
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Edoxaban.
exisulindexisulind may increase the anticoagulant activities of Edoxaban.
FelodipineThe serum concentration of Edoxaban can be increased when it is combined with Felodipine.
FenbufenFenbufen may increase the anticoagulant activities of Edoxaban.
FenoprofenFenoprofen may increase the anticoagulant activities of Edoxaban.
FentanylThe serum concentration of Edoxaban can be increased when it is combined with Fentanyl.
FexofenadineThe serum concentration of Edoxaban can be increased when it is combined with Fexofenadine.
FibrinolysinFibrinolysin may increase the anticoagulant activities of Edoxaban.
FidaxomicinThe serum concentration of Edoxaban can be increased when it is combined with Fidaxomicin.
FloctafenineFloctafenine may increase the anticoagulant activities of Edoxaban.
FluconazoleThe serum concentration of Edoxaban can be increased when it is combined with Fluconazole.
FlunixinFlunixin may increase the anticoagulant activities of Edoxaban.
FluoxetineThe serum concentration of Edoxaban can be increased when it is combined with Fluoxetine.
FlupentixolThe serum concentration of Edoxaban can be increased when it is combined with Flupentixol.
FluphenazineThe serum concentration of Edoxaban can be increased when it is combined with Fluphenazine.
FlurazepamThe serum concentration of Edoxaban can be increased when it is combined with Flurazepam.
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Edoxaban.
FluvoxamineThe serum concentration of Edoxaban can be increased when it is combined with Fluvoxamine.
Fondaparinux sodiumEdoxaban may increase the anticoagulant activities of Fondaparinux sodium.
GarlicThe serum concentration of Edoxaban can be decreased when it is combined with Garlic.
GefitinibThe serum concentration of Edoxaban can be increased when it is combined with Gefitinib.
GenisteinThe serum concentration of Edoxaban can be increased when it is combined with Genistein.
GestodeneThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Gestodene.
GlyburideThe serum concentration of Edoxaban can be increased when it is combined with Glyburide.
GlycerolThe serum concentration of Edoxaban can be increased when it is combined with Glycerol.
Gramicidin DThe serum concentration of Edoxaban can be increased when it is combined with Gramicidin D.
GrepafloxacinThe serum concentration of Edoxaban can be increased when it is combined with Grepafloxacin.
HaloperidolThe serum concentration of Edoxaban can be increased when it is combined with Haloperidol.
HeminHemin may increase the anticoagulant activities of Edoxaban.
HeparinEdoxaban may increase the anticoagulant activities of Heparin.
HexestrolHexestrol may decrease the anticoagulant activities of Edoxaban.
HirulogEdoxaban may increase the anticoagulant activities of Hirulog.
HMPL-004HMPL-004 may increase the anticoagulant activities of Edoxaban.
HydrocortisoneThe serum concentration of Edoxaban can be increased when it is combined with Hydrocortisone.
Hydroxyprogesterone caproateThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Hydroxyprogesterone caproate.
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Edoxaban is combined with Ibritumomab tiuxetan.
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Edoxaban.
IbudilastIbudilast may increase the anticoagulant activities of Edoxaban.
IbuprofenIbuprofen may increase the anticoagulant activities of Edoxaban.
IbuproxamIbuproxam may increase the anticoagulant activities of Edoxaban.
IcatibantIcatibant may increase the anticoagulant activities of Edoxaban.
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Edoxaban.
IdelalisibThe serum concentration of Edoxaban can be increased when it is combined with Idelalisib.
IfenprodilIfenprodil may increase the anticoagulant activities of Edoxaban.
IloprostIloprost may increase the anticoagulant activities of Edoxaban.
ImatinibThe serum concentration of Edoxaban can be increased when it is combined with Imatinib.
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Edoxaban.
IndinavirThe serum concentration of Edoxaban can be decreased when it is combined with Indinavir.
IndomethacinIndomethacin may increase the anticoagulant activities of Edoxaban.
IndoprofenIndoprofen may increase the anticoagulant activities of Edoxaban.
IsavuconazoniumThe serum concentration of Edoxaban can be increased when it is combined with Isavuconazonium.
IsoxicamIsoxicam may increase the anticoagulant activities of Edoxaban.
ItraconazoleThe serum concentration of Edoxaban can be increased when it is combined with Itraconazole.
IvacaftorThe serum concentration of Edoxaban can be increased when it is combined with Ivacaftor.
IvermectinThe serum concentration of Edoxaban can be increased when it is combined with Ivermectin.
KebuzoneKebuzone may increase the anticoagulant activities of Edoxaban.
KetamineThe serum concentration of Edoxaban can be increased when it is combined with Ketamine.
KetoconazoleThe serum concentration of Edoxaban can be increased when it is combined with Ketoconazole.
KetoprofenKetoprofen may increase the anticoagulant activities of Edoxaban.
KetorolacKetorolac may increase the anticoagulant activities of Edoxaban.
LansoprazoleThe serum concentration of Edoxaban can be increased when it is combined with Lansoprazole.
LapatinibThe serum concentration of Edoxaban can be increased when it is combined with Lapatinib.
LeflunomideLeflunomide may increase the anticoagulant activities of Edoxaban.
LepirudinEdoxaban may increase the anticoagulant activities of Lepirudin.
LevofloxacinThe serum concentration of Edoxaban can be increased when it is combined with Levofloxacin.
LevonorgestrelThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Levonorgestrel.
LevothyroxineThe serum concentration of Edoxaban can be decreased when it is combined with Levothyroxine.
LidocaineThe serum concentration of Edoxaban can be increased when it is combined with Lidocaine.
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Edoxaban.
LiothyronineThe serum concentration of Edoxaban can be decreased when it is combined with Liothyronine.
LiotrixThe serum concentration of Edoxaban can be decreased when it is combined with Liotrix.
LisinoprilThe serum concentration of Edoxaban can be increased when it is combined with Lisinopril.
LomitapideThe serum concentration of Edoxaban can be increased when it is combined with Lomitapide.
LoperamideThe serum concentration of Edoxaban can be increased when it is combined with Loperamide.
LopinavirThe serum concentration of Edoxaban can be increased when it is combined with Lopinavir.
LoratadineThe serum concentration of Edoxaban can be increased when it is combined with Loratadine.
LornoxicamLornoxicam may increase the anticoagulant activities of Edoxaban.
LosartanThe serum concentration of Edoxaban can be increased when it is combined with Losartan.
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Edoxaban.
LoxoprofenLoxoprofen may increase the anticoagulant activities of Edoxaban.
LumacaftorThe serum concentration of Edoxaban can be decreased when it is combined with Lumacaftor.
LumiracoxibLumiracoxib may increase the anticoagulant activities of Edoxaban.
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Edoxaban.
MaprotilineThe serum concentration of Edoxaban can be increased when it is combined with Maprotiline.
MasoprocolMasoprocol may increase the anticoagulant activities of Edoxaban.
MebendazoleThe serum concentration of Edoxaban can be increased when it is combined with Mebendazole.
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Edoxaban.
MedrogestoneThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Medrogestone.
Medroxyprogesterone acetateThe therapeutic efficacy of Edoxaban can be decreased when used in combination with Medroxyprogesterone acetate.
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Edoxaban.
MefloquineThe serum concentration of Edoxaban can be increased when it is combined with Mefloquine.
Megestrol acetateThe serum concentration of Edoxaban can be increased when it is combined with Megestrol acetate.
MeloxicamMeloxicam may increase the anticoagulant activities of Edoxaban.
MeprobamateThe serum concentration of Edoxaban can be increased when it is combined with Meprobamate.
MesalazineMesalazine may increase the anticoagulant activities of Edoxaban.
MestranolMestranol may decrease the anticoagulant activities of Edoxaban.
MetamizoleMetamizole may increase the anticoagulant activities of Edoxaban.
MethadoneThe serum concentration of Edoxaban can be increased when it is combined with Methadone.
MetoprololThe serum concentration of Edoxaban can be increased when it is combined with Metoprolol.
MibefradilThe serum concentration of Edoxaban can be increased when it is combined with Mibefradil.
MiconazoleThe serum concentration of Edoxaban can be increased when it is combined with Miconazole.
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Edoxaban.
MidazolamThe serum concentration of Edoxaban can be decreased when it is combined with Midazolam.
MifepristoneThe serum concentration of Edoxaban can be decreased when it is combined with Mifepristone.
MilrinoneMilrinone may increase the anticoagulant activities of Edoxaban.
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Edoxaban.
MitomycinThe serum concentration of Edoxaban can be increased when it is combined with Mitomycin.
MitoxantroneThe serum concentration of Edoxaban can be decreased when it is combined with Mitoxantrone.
MorphineThe serum concentration of Edoxaban can be increased when it is combined with Morphine.
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Edoxaban.
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Edoxaban.
NabumetoneNabumetone may increase the anticoagulant activities of Edoxaban.
NadroparinEdoxaban may increase the anticoagulant activities of Nadroparin.
NaftifineNaftifine may increase the anticoagulant activities of Edoxaban.
NaltrexoneThe serum concentration of Edoxaban can be increased when it is combined with Naltrexone.
NaproxenNaproxen may increase the anticoagulant activities of Edoxaban.
NaringeninThe serum concentration of Edoxaban can be increased when it is combined with Naringenin.
NCX 4016NCX 4016 may increase the anticoagulant activities of Edoxaban.
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Edoxaban.
NefazodoneThe serum concentration of Edoxaban can be decreased when it is combined with Nefazodone.
NelfinavirThe serum concentration of Edoxaban can be decreased when it is combined with Nelfinavir.
NeostigmineThe serum concentration of Edoxaban can be increased when it is combined with Neostigmine.
NepafenacNepafenac may increase the anticoagulant activities of Edoxaban.
NicardipineThe serum concentration of Edoxaban can be increased when it is combined with Nicardipine.
NifedipineThe serum concentration of Edoxaban can be decreased when it is combined with Nifedipine.
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Edoxaban.
NilotinibThe serum concentration of Edoxaban can be increased when it is combined with Nilotinib.
NimesulideNimesulide may increase the anticoagulant activities of Edoxaban.
NintedanibThe risk or severity of adverse effects can be increased when Edoxaban is combined with Nintedanib.
NisoldipineThe serum concentration of Edoxaban can be increased when it is combined with Nisoldipine.
NitrazepamThe serum concentration of Edoxaban can be increased when it is combined with Nitrazepam.
NitrendipineThe serum concentration of Edoxaban can be increased when it is combined with Nitrendipine.
NorethisteroneThe serum concentration of Edoxaban can be decreased when it is combined with Norethisterone.
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Edoxaban.
ObinutuzumabThe risk or severity of adverse effects can be increased when Edoxaban is combined with Obinutuzumab.
OlopatadineOlopatadine may increase the anticoagulant activities of Edoxaban.
OlsalazineOlsalazine may increase the anticoagulant activities of Edoxaban.
Omacetaxine mepesuccinateThe risk or severity of adverse effects can be increased when Edoxaban is combined with Omacetaxine mepesuccinate.
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Edoxaban.
OmeprazoleThe serum concentration of Edoxaban can be increased when it is combined with Omeprazole.
OrgoteinOrgotein may increase the anticoagulant activities of Edoxaban.
OtamixabanEdoxaban may increase the anticoagulant activities of Otamixaban.
OxaprozinOxaprozin may increase the anticoagulant activities of Edoxaban.
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Edoxaban.
P-NitrophenolThe serum concentration of Edoxaban can be increased when it is combined with P-Nitrophenol.
PaclitaxelThe serum concentration of Edoxaban can be increased when it is combined with Paclitaxel.
Palmitic AcidThe serum concentration of Edoxaban can be increased when it is combined with Palmitic Acid.
PantoprazoleThe serum concentration of Edoxaban can be increased when it is combined with Pantoprazole.
ParecoxibParecoxib may increase the anticoagulant activities of Edoxaban.
ParnaparinParnaparin may increase the anticoagulant activities of Edoxaban.
ParoxetineThe serum concentration of Edoxaban can be increased when it is combined with Paroxetine.
Pentosan PolysulfateEdoxaban may increase the anticoagulant activities of Pentosan Polysulfate.
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Edoxaban.
PerindoprilThe serum concentration of Edoxaban can be increased when it is combined with Perindopril.
PethidineThe risk or severity of adverse effects can be increased when Edoxaban is combined with Pethidine.
PhenindioneEdoxaban may increase the anticoagulant activities of Phenindione.
PhenobarbitalThe serum concentration of Edoxaban can be decreased when it is combined with Phenobarbital.
PhenprocoumonEdoxaban may increase the anticoagulant activities of Phenprocoumon.
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Edoxaban.
PimecrolimusPimecrolimus may increase the anticoagulant activities of Edoxaban.
PimozideThe serum concentration of Pimozide can be increased when it is combined with Edoxaban.
PirfenidonePirfenidone may increase the anticoagulant activities of Edoxaban.
PiroxicamPiroxicam may increase the anticoagulant activities of Edoxaban.
PlasminPlasmin may increase the anticoagulant activities of Edoxaban.
Platelet Activating FactorThe serum concentration of Edoxaban can be decreased when it is combined with Platelet Activating Factor.
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Edoxaban.
PonatinibThe serum concentration of Edoxaban can be increased when it is combined with Ponatinib.
PosaconazoleThe serum concentration of Edoxaban can be increased when it is combined with Posaconazole.
PrasugrelPrasugrel may increase the anticoagulant activities of Edoxaban.
PravastatinThe serum concentration of Edoxaban can be increased when it is combined with Pravastatin.
PrazosinThe serum concentration of Edoxaban can be increased when it is combined with Prazosin.
PrednisoneThe serum concentration of Edoxaban can be increased when it is combined with Prednisone.
ProbenecidThe serum concentration of Edoxaban can be increased when it is combined with Probenecid.
ProgesteroneThe serum concentration of Edoxaban can be decreased when it is combined with Progesterone.
PromethazineThe serum concentration of Edoxaban can be increased when it is combined with Promethazine.
PropacetamolPropacetamol may increase the anticoagulant activities of Edoxaban.
PropafenoneThe serum concentration of Edoxaban can be increased when it is combined with Propafenone.
PropranololThe serum concentration of Edoxaban can be increased when it is combined with Propranolol.
Protein CEdoxaban may increase the anticoagulant activities of Protein C.
ProtocatechualdehydeEdoxaban may increase the anticoagulant activities of Protocatechualdehyde.
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Edoxaban.
PTC299PTC299 may increase the anticoagulant activities of Edoxaban.
QuercetinThe serum concentration of Edoxaban can be increased when it is combined with Quercetin.
QuinacrineThe serum concentration of Edoxaban can be increased when it is combined with Quinacrine.
QuinestrolQuinestrol may decrease the anticoagulant activities of Edoxaban.
QuinidineThe serum concentration of Edoxaban can be increased when it is combined with Quinidine.
QuinineThe serum concentration of Edoxaban can be increased when it is combined with Quinine.
RanitidineThe serum concentration of Edoxaban can be increased when it is combined with Ranitidine.
RanolazineThe serum concentration of Edoxaban can be increased when it is combined with Ranolazine.
ReboxetineThe serum concentration of Edoxaban can be increased when it is combined with Reboxetine.
RegorafenibThe serum concentration of Edoxaban can be increased when it is combined with Regorafenib.
ReserpineThe serum concentration of Edoxaban can be decreased when it is combined with Reserpine.
ResveratrolResveratrol may increase the anticoagulant activities of Edoxaban.
ReteplaseReteplase may increase the anticoagulant activities of Edoxaban.
ReviparinEdoxaban may increase the anticoagulant activities of Reviparin.
RidogrelRidogrel may increase the anticoagulant activities of Edoxaban.
RifampicinThe serum concentration of Edoxaban can be decreased when it is combined with Rifampicin.
RilpivirineThe serum concentration of Edoxaban can be increased when it is combined with Rilpivirine.
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Edoxaban.
RitonavirThe serum concentration of Edoxaban can be decreased when it is combined with Ritonavir.
RivaroxabanEdoxaban may increase the anticoagulant activities of Rivaroxaban.
RofecoxibRofecoxib may increase the anticoagulant activities of Edoxaban.
RolapitantThe serum concentration of Edoxaban can be increased when it is combined with Rolapitant.
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Edoxaban.
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Edoxaban.
SalicylamideSalicylamide may increase the anticoagulant activities of Edoxaban.
Salicylic acidSalicylic acid may increase the anticoagulant activities of Edoxaban.
SalsalateSalsalate may increase the anticoagulant activities of Edoxaban.
SaquinavirThe serum concentration of Edoxaban can be decreased when it is combined with Saquinavir.
SCH-530348SCH-530348 may increase the anticoagulant activities of Edoxaban.
ScopolamineThe serum concentration of Edoxaban can be increased when it is combined with Scopolamine.
SelegilineThe serum concentration of Edoxaban can be increased when it is combined with Selegiline.
SelexipagSelexipag may increase the anticoagulant activities of Edoxaban.
SeratrodastSeratrodast may increase the anticoagulant activities of Edoxaban.
SertralineThe serum concentration of Edoxaban can be increased when it is combined with Sertraline.
SevofluraneSevoflurane may increase the anticoagulant activities of Edoxaban.
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Edoxaban.
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Edoxaban.
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Edoxaban.
SirolimusThe serum concentration of Edoxaban can be decreased when it is combined with Sirolimus.
SorafenibThe serum concentration of Edoxaban can be increased when it is combined with Sorafenib.
SpironolactoneThe serum concentration of Edoxaban can be increased when it is combined with Spironolactone.
SRT501SRT501 may increase the anticoagulant activities of Edoxaban.
St. John's WortThe metabolism of Edoxaban can be increased when combined with St. John's Wort.
StaurosporineThe serum concentration of Edoxaban can be increased when it is combined with Staurosporine.
StreptokinaseStreptokinase may increase the anticoagulant activities of Edoxaban.
StreptozocinThe serum concentration of Edoxaban can be decreased when it is combined with Streptozocin.
SugammadexSugammadex may increase the anticoagulant activities of Edoxaban.
SulfasalazineSulfasalazine may increase the anticoagulant activities of Edoxaban.
SulfinpyrazoneThe serum concentration of Edoxaban can be increased when it is combined with Sulfinpyrazone.
SulindacSulindac may increase the anticoagulant activities of Edoxaban.
SulodexideEdoxaban may increase the anticoagulant activities of Sulodexide.
SumatriptanThe serum concentration of Edoxaban can be increased when it is combined with Sumatriptan.
SunitinibThe serum concentration of Edoxaban can be increased when it is combined with Sunitinib.
SuprofenSuprofen may increase the anticoagulant activities of Edoxaban.
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Edoxaban.
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Edoxaban.
TacrineThe serum concentration of Edoxaban can be increased when it is combined with Tacrine.
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Edoxaban.
TacrolimusThe serum concentration of Edoxaban can be decreased when it is combined with Tacrolimus.
TamoxifenThe serum concentration of Edoxaban can be decreased when it is combined with Tamoxifen.
Taurocholic AcidThe serum concentration of Edoxaban can be increased when it is combined with Taurocholic Acid.
TelmisartanThe serum concentration of Edoxaban can be increased when it is combined with Telmisartan.
TemsirolimusThe risk or severity of adverse effects can be increased when Edoxaban is combined with Temsirolimus.
TemsirolimusThe serum concentration of Edoxaban can be increased when it is combined with Temsirolimus.
TenecteplaseTenecteplase may increase the anticoagulant activities of Edoxaban.
TenoxicamTenoxicam may increase the anticoagulant activities of Edoxaban.
TepoxalinTepoxalin may increase the anticoagulant activities of Edoxaban.
TerazosinThe serum concentration of Edoxaban can be increased when it is combined with Terazosin.
TerfenadineThe serum concentration of Edoxaban can be increased when it is combined with Terfenadine.
TeriflunomideTeriflunomide may increase the anticoagulant activities of Edoxaban.
TesmilifeneTesmilifene may increase the anticoagulant activities of Edoxaban.
TestosteroneThe serum concentration of Edoxaban can be increased when it is combined with Testosterone.
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Edoxaban.
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Edoxaban.
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Edoxaban.
TiboloneTibolone may increase the anticoagulant activities of Edoxaban.
TicagrelorTicagrelor may increase the anticoagulant activities of Edoxaban.
TiclopidineTiclopidine may increase the anticoagulant activities of Edoxaban.
TinzaparinTinzaparin may increase the anticoagulant activities of Edoxaban.
TipranavirThe serum concentration of Edoxaban can be decreased when it is combined with Tipranavir.
TirofibanTirofiban may increase the anticoagulant activities of Edoxaban.
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Edoxaban.
TolmetinTolmetin may increase the anticoagulant activities of Edoxaban.
TolvaptanThe serum concentration of Edoxaban can be increased when it is combined with Tolvaptan.
TositumomabThe risk or severity of adverse effects can be increased when Edoxaban is combined with Tositumomab.
TranilastTranilast may increase the anticoagulant activities of Edoxaban.
TrapidilTrapidil may increase the anticoagulant activities of Edoxaban.
TrazodoneThe serum concentration of Edoxaban can be decreased when it is combined with Trazodone.
TreprostinilTreprostinil may increase the anticoagulant activities of Edoxaban.
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Edoxaban.
TrifluoperazineThe serum concentration of Edoxaban can be increased when it is combined with Trifluoperazine.
TriflupromazineThe serum concentration of Edoxaban can be increased when it is combined with Triflupromazine.
TriflusalTriflusal may increase the anticoagulant activities of Edoxaban.
TrimethoprimThe serum concentration of Edoxaban can be decreased when it is combined with Trimethoprim.
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Edoxaban.
Trisalicylate-cholineTrisalicylate-choline may increase the anticoagulant activities of Edoxaban.
TroleandomycinThe serum concentration of Edoxaban can be increased when it is combined with Troleandomycin.
UrokinaseUrokinase may increase the anticoagulant activities of Edoxaban.
ValdecoxibValdecoxib may increase the anticoagulant activities of Edoxaban.
VenlafaxineThe serum concentration of Edoxaban can be increased when it is combined with Venlafaxine.
VerapamilThe serum concentration of Edoxaban can be decreased when it is combined with Verapamil.
VinblastineThe serum concentration of Edoxaban can be decreased when it is combined with Vinblastine.
VincristineThe serum concentration of Edoxaban can be decreased when it is combined with Vincristine.
VinorelbineThe serum concentration of Edoxaban can be increased when it is combined with Vinorelbine.
Vitamin EVitamin E may increase the anticoagulant activities of Edoxaban.
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Edoxaban.
WarfarinEdoxaban may increase the anticoagulant activities of Warfarin.
XimelagatranEdoxaban may increase the anticoagulant activities of Ximelagatran.
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Edoxaban.
ZeranolZeranol may decrease the anticoagulant activities of Edoxaban.
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Edoxaban.
ZileutonZileuton may increase the anticoagulant activities of Edoxaban.
ZimelidineThe serum concentration of Edoxaban can be increased when it is combined with Zimelidine.
ZomepiracZomepirac may increase the anticoagulant activities of Edoxaban.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Serine-type endopeptidase activity
Specific Function:
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Gene Name:
F10
Uniprot ID:
P00742
Molecular Weight:
54731.255 Da
References
  1. Turpie AG: New oral anticoagulants in atrial fibrillation. Eur Heart J. 2008 Jan;29(2):155-65. Epub 2007 Dec 19. [PubMed:18096568 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Mikkaichi T, Yoshigae Y, Masumoto H, Imaoka T, Rozehnal V, Fischer T, Okudaira N, Izumi T: Edoxaban transport via P-glycoprotein is a key factor for the drug's disposition. Drug Metab Dispos. 2014 Apr;42(4):520-8. doi: 10.1124/dmd.113.054866. Epub 2014 Jan 23. [PubMed:24459178 ]
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Drug created on May 15, 2015 10:35 / Updated on August 30, 2016 02:13