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Identification
NamePromethazine
Accession NumberDB01069  (APRD00601)
TypeSmall Molecule
GroupsApproved
Description

A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. [PubChem]

Structure
Thumb
Synonyms
SynonymLanguageCode
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazineNot AvailableNot Available
10-(2-Dimethylaminopropyl)phenothiazineNot AvailableNot Available
10-[2-(dimethylamino)Propyl]phenothiazineNot AvailableNot Available
N-(2'-dimethylamino-2'-Methyl)ethylphenothiazineNot AvailableNot Available
N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamineNot AvailableNot Available
N,N,α-trimethyl-10H-phenothiazine-10-ethanamineNot AvailableNot Available
ProazamineNot AvailableNot Available
PrometazinaNot AvailableNot Available
PromethazineNot AvailableNot Available
PromethazinumNot AvailableNot Available
Prescription ProductsNot Available
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Promethazine Hydrochloridetablet12.5 mgoralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2008-02-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2008-02-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2008-05-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscular; intravenousWest ward Pharmaceutical Corp2008-04-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest ward Pharmaceutical Corp2008-04-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousHospira, Inc.2009-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousHospira, Inc.2009-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralLiberty Pharmaceuticals, Inc.2012-07-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository25 mgrectalPaddock Laboratories, Inc.2003-06-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository12.5 mgrectalPaddock Laboratories, Inc.2003-06-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository12.5 mgrectalWatson Laboratories, Inc.2013-02-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository25 mgrectalWatson Laboratories, Inc.2013-04-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralWatson Laboratories, Inc.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralWatson Laboratories, Inc.1973-09-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralQualitest Pharmaceuticals2006-04-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralQualitest Pharmaceuticals2006-07-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralQualitest Pharmaceuticals2006-07-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralQualitest Pharmaceuticals2006-07-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazinetablet12.5 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousTeva Parenteral Medicines, Inc.2002-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution50 mg/mLintramuscular; intravenousTeva Parenteral Medicines, Inc.2002-10-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository50 mgrectalG&W Laboratories, Inc.1987-08-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mgrectalG&W Laboratories, Inc.2002-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository12.5 mgrectalG&W Laboratories, Inc.2004-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralSandoz Inc1975-12-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralSandoz Inc1975-02-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralMajor Pharmaceuticals2008-05-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralMajor Pharmaceuticals2011-07-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousBaxter Healthcare Corporation2009-12-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralBlenheim Pharmacal, Inc.2010-05-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralKvk Tech, Inc.2014-07-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralKvk Tech, Inc.2014-07-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralKvk Tech, Inc.2014-07-09Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralApotheca, Inc1999-06-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralSTAT Rx USA LLC2006-07-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralSTAT Rx USA LLC1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralAtlantic Biologicals Corps1982-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralRebel Distributors Corp1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralRebel Distributors Corp2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mgrectalRebel Distributors Corp2003-06-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralRebel Distributors Corp1982-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralRebel Distributors Corp2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mgrectalRebel Distributors Corp2002-02-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2012-08-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2012-12-21Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-04-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralTris Pharma Inc2012-08-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralAidarex Pharmaceuticals LLC2012-07-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralAidarex Pharmaceuticals LLC2012-07-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousX Gen Pharmaceuticals, Inc.2011-05-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousX Gen Pharmaceuticals, Inc.2015-01-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution50 mg/mLintramuscular; intravenousX Gen Pharmaceuticals, Inc.2015-01-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenergansuppository12.5 mgrectalPrestium Pharma, Inc.2014-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenergansuppository25 mgrectalPrestium Pharma, Inc.2014-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenergansuppository50 mgrectalPrestium Pharma, Inc.2014-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository12.5 mgrectalRenaissance Pharma, Inc.2014-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mgrectalRenaissance Pharma, Inc.2014-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository50 mgrectalRenaissance Pharma, Inc.2014-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralRebel Distributors Corp2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralSTAT Rx USA LLC1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralPd Rx Pharmaceuticals, Inc.2008-02-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mgrectalPd Rx Pharmaceuticals, Inc.2006-05-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralPd Rx Pharmaceuticals, Inc.2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralPd Rx Pharmaceuticals, Inc.2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository12.5 mgrectalPerrigo New York Inc2006-06-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mgrectalPerrigo New York Inc2006-05-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository25 mgrectalREMEDYREPACK INC.2013-05-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralLake Erie Medical DBA Quality Care Products LLC2010-11-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralLake Erie Medical DBA Quality Care Products LLC2010-10-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralHi Tech Pharmacal Co., Inc.1998-09-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralUnit Dose Services2012-07-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralMylan Institutional Inc.2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralNorthwind Pharmaceuticals2014-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralNorthwind Pharmaceuticals2014-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/301oralNorthwind Pharmaceuticals2014-05-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/301oralNorthwind Pharmaceuticals2014-05-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-03-25Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-05-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mgintramuscularREMEDYREPACK INC.2013-04-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2014-02-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-05-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mgrectalREMEDYREPACK INC.2013-06-04Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-05-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-10-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-12-05Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2014-10-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-12-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2014-11-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2013-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscularREMEDYREPACK INC.2014-02-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscularREMEDYREPACK INC.2014-06-11Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution50 mg/mLintramuscularGeneral Injectables & Vaccines, Inc2010-08-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralH.J. Harkins Company, Inc.2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mgrectalH.J. Harkins Company, Inc.2002-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralState of Florida DOH Central Pharmacy2009-07-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralA S Medication Solutions Llc2006-04-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralA S Medication Solutions Llc2012-07-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralA S Medication Solutions Llc2012-07-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazineinjection50 mg/mLintramuscularPhysicians Total Care, Inc.2002-08-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mgrectalPhysicians Total Care, Inc.2003-02-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralPhysicians Total Care, Inc.1995-08-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository50 mgrectalPhysicians Total Care, Inc.1996-06-17Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralPhysicians Total Care, Inc.1994-12-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2005-09-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralPhysicians Total Care, Inc.1997-03-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2000-02-29Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository12.5 mgrectalPhysicians Total Care, Inc.2003-05-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralPhysicians Total Care, Inc.2005-05-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralDispensing Solutions, Inc.2006-04-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazineinjection25 mg/mLintramuscular; intravenousCardinal Health2002-08-22Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralCardinal Health2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousCardinal Health1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousCardinal Health1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralCardinal Health1982-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralCardinal Health2006-09-08Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousCardinal Health1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousCardinal Health2010-01-26Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralCardinal Health2012-08-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralPd Rx Pharmaceuticals, Inc.2008-02-12Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralPd Rx Pharmaceuticals, Inc.2008-05-20Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mgrectalPd Rx Pharmaceuticals, Inc.2002-02-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository12.5 mgrectalPd Rx Pharmaceuticals, Inc.2003-06-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralCaraco Pharmaceutical Laboratories, Ltd.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralCaraco Pharmaceutical Laboratories, Ltd.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralCaraco Pharmaceutical Laboratories, Ltd.2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralCaraco Pharmaceutical Laboratories, Ltd.2009-03-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralClinical Solutions Wholesale2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralClinical Solutions Wholesale1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralGolden State Medical Supply, Inc.2006-07-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralGolden State Medical Supply, Inc.2006-07-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralGolden State Medical Supply, Inc.2006-07-31Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralMorton Grove Pharmaceuticals, Inc.1982-11-15Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection, solution25 mg/mLintramuscular; intravenousBaxter Healthcare Corporation2009-12-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection, solution50 mg/mLintramuscularBaxter Healthcare Corporation2009-12-10Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralREMEDYREPACK INC.2014-10-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralDIRECT RX2014-01-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralProficient Rx LP2009-01-27Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralbryant ranch prepack2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralbryant ranch prepack1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralbryant ranch prepack2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2008-08-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2009-08-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralReady Meds2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralReady Meds2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralTYA Pharmaceuticals2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralTYA Pharmaceuticals1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralAmneal Pharmaceuticals2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralAmneal Pharmaceuticals2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralAmneal Pharmaceuticals, LLC2009-12-30Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralAmneal Pharmaceuticals2011-03-03Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralCadila Healthcare Limited2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralCadila Healthcare Limited2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralCadila Healthcare Limited2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralMed Vantx, Inc.2006-07-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralDispensing Solutions, Inc.2006-07-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralBlue Point Laboratories2014-01-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralBlue Point Laboratories2014-01-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralBlue Point Laboratories2014-01-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralAmerican Health Packaging2013-07-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralAmerican Health Packaging2013-07-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mgrectalDispensing Solutions Inc.2003-12-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousDispensing Solutions Inc.2009-05-28Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mgoralZydus Pharmaceuticals (USA) Inc.2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralZydus Pharmaceuticals (USA) Inc.2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mgoralZydus Pharmaceuticals (USA) Inc.2005-12-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralPreferred Pharmaceuticals, Inc.2013-09-23Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralPreferred Pharmaceuticals, Inc.1973-09-19Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralPreferred Pharmaceuticals, Inc.2014-01-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralPreferred Pharmaceuticals, Inc.2013-11-13Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralPreferred Pharmaceuticals, Inc.2013-04-24Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralLife Line Home Care Services, Inc.2006-07-18Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralMc Kesson Contract Packaging2011-09-14Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mgoralMc Kesson Contract Packaging2012-02-02Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sominextablet25 mgoralGlaxo Smith Kline Consumer Healthcare Lp2010-11-082017-09-30Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sominextablet50 mgoralGlaxo Smith Kline Consumer Healthcare Lp2010-11-082015-07-31Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Sominextablet25 mgoralMedtech Products Inc.2012-06-01Not AvailableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
International Brands
NameCompany
AvomineNot Available
FarganNot Available
FarganesseNot Available
LergiganNot Available
ProthiazineNot Available
ReceptozineNot Available
RomerganNot Available
Brand mixtures
Brand NameIngredients
Phenergan VC Expectorant SyrupPhenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride
Salts
Name/CASStructureProperties
Promethazine hydrochloride
58-33-3
Thumb
  • InChI Key: XXPDBLUZJRXNNZ-UHFFFAOYNA-N
  • Monoisotopic Mass: 320.111397079
  • Average Mass: 320.88
DBSALT000427
Categories
CAS number60-87-7
WeightAverage: 284.419
Monoisotopic: 284.13471934
Chemical FormulaC17H20N2S
InChI KeyPWWVAXIEGOYWEE-UHFFFAOYSA-N
InChI
InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
IUPAC Name
dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine
SMILES
CC(CN1C2=CC=CC=C2SC2=CC=CC=C12)N(C)C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazines
Sub ClassPhenothiazines
Direct ParentPhenothiazines
Alternative Parents
Substituents
  • Phenothiazine
  • Alkyldiarylamine
  • Diarylthioether
  • Benzenoid
  • Para-thiazine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Thioether
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of allergic disorders, and nausea/vomiting.
PharmacodynamicsPromethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Mechanism of actionLike other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone.
AbsorptionOn average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Volume of distributionNot Available
Protein binding93%
Metabolism

Hepatic

Route of eliminationPromethazine hydrochloride is metabolized in the liver, with the sulfoxides of promethazine and N-desmethylpromethazine being the predominant metabolites appearing in the urine.
Half life16-19 hours
ClearanceNot Available
ToxicitySymptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9832
Blood Brain Barrier+0.9855
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8157
P-glycoprotein inhibitor IInhibitor0.8408
P-glycoprotein inhibitor IINon-inhibitor0.6473
Renal organic cation transporterInhibitor0.5156
CYP450 2C9 substrateNon-substrate0.7736
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.5338
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 substrateNon-inhibitor0.9341
CYP450 2D6 substrateInhibitor0.8931
CYP450 2C19 substrateNon-inhibitor0.9025
CYP450 3A4 substrateNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.567
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9088
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6959 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9786
hERG inhibition (predictor II)Inhibitor0.7661
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Injectionintramuscular25 mg/mL
Injectionintramuscular50 mg/mL
Injectionintramuscular; intravenous25 mg/mL
Injectionintramuscular; intravenous50 mg/mL
Injection, solutionintramuscular25 mg
Injection, solutionintramuscular50 mg/mL
Injection, solutionintramuscular; intravenous25 mg/mL
Injection, solutionintramuscular; intravenous50 mg/mL
Solutionoral6.25 mg/5mL
Suppositoryrectal12.5 mg
Suppositoryrectal25 mg
Suppositoryrectal50 mg
Syruporal6.25 mg/5mL
Tabletoral12.5 mg
Tabletoral25 mg
Tabletoral25 mg/301
Tabletoral50 mg
Prices
Unit descriptionCostUnit
Promethegan 12 50 mg Suppository Box101.64USD box
Phenergan 12 50 mg Suppository Box80.16USD box
Phenergan 12 25 mg Suppository Box62.59USD box
Promethegan 12 25 mg Suppository Box62.27USD box
Promethazine HCl 12 50 mg Suppository Box60.94USD box
Phenergan 12 12.5 mg Suppository Box54.58USD box
Phenergan 25 mg suppository8.32USD suppository
Promethegan 50 mg suppository8.14USD suppository
Phenergan 12.5 mg suppository7.94USD suppository
Phenergan 50 mg suppository7.39USD suppository
Promethazine 50 mg suppository4.88USD suppository
Promethegan 25 mg suppository4.62USD suppository
Phenadoz 25 mg suppository4.45USD suppository
Promethazine 25 mg suppository4.32USD suppository
Promethegan 12.5 mg suppository4.02USD suppository
Promethazine HCl 12.5 mg Suppository4.0USD suppository
Phenadoz 12.5 mg suppository3.89USD suppository
Phenergan 25 mg/ml ampul3.84USD ml
Promethazine 12.5 mg suppository3.82USD suppository
Phenergan 50 mg/ml ampul3.68USD ml
Promethazine HCl 50 mg/ml Solution 1ml Ampule2.8USD ampule
Promethazine 50 mg/ml ampul2.25USD ml
Promethazine hcl powder2.14USD g
Promethazine 25 mg/ml ampul1.1USD ml
Promethazine 25 mg/ml1.06USD ml
Promethazine HCl 50 mg tablet0.81USD tablet
Promethazine 50 mg tablet0.78USD tablet
Promethazine HCl 25 mg tablet0.73USD tablet
Phenergan 25 mg tablet0.62USD tablet
Promethazine 25 mg tablet0.51USD tablet
Promethazine 12.5 mg tablet0.49USD tablet
Promethazine-DM 6.25-15 mg/5ml Syrup0.18USD ml
Promethazine HCl 6.25 mg/5ml Syrup0.11USD ml
Promethazine VC Plain 6.25-5 mg/5ml Syrup0.09USD ml
Promethazine-Codeine 6.25-10 mg/5ml Syrup0.06USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point60 °CPhysProp
boiling point190-192 °C at 3.00E+00 mm HgPhysProp
water solubility15.6 mg/L (at 24 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP4.81HANSCH,C ET AL. (1995)
logS-4.26ADME Research, USCD
pKa9.1SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0245 mg/mLALOGPS
logP4.52ALOGPS
logP4.29ChemAxon
logS-4.1ALOGPS
pKa (Strongest Basic)9.05ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area6.48 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity88.5 m3·mol-1ChemAxon
Polarizability32.38 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.88 KB)
SpectraMS
References
Synthesis Reference

DrugSyn.org

US2530451
General Reference
  1. Peters RJ Jr, Kelder SH, Markham CM, Yacoubian GS Jr, Peters LA, Ellis A: Beliefs and social norms about codeine and promethazine hydrochloride cough syrup (CPHCS) onset and perceived addiction among urban Houstonian adolescents: an addiction trend in the city of lean. J Drug Educ. 2003;33(4):415-25. Pubmed
External Links
ATC CodesD04AA10R06AD02
AHFS Codes
  • 04:04.12
PDB EntriesNot Available
FDA labelDownload (93.4 KB)
MSDSDownload (74.8 KB)
Interactions
Drug Interactions
Drug
AmphetamineDecreased anorexic effect, may increase pyschotic symptoms
BenzphetamineAntipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
BromocriptineThe phenothiazine decreases the effect of bromocriptine
CisaprideIncreased risk of cardiotoxicity and arrhythmias
DesvenlafaxineIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
DexfenfluramineDecreased anorexic effect, may increase pyschotic symptoms.
DextroamphetamineDecreased anorexic effect, may increase pyschotic symptoms
DiethylpropionDecreased anorexic effect, may increase psychotic symptoms.
DonepezilPossible antagonism of action
FenfluramineDecreased anorexic effect, may increase psychotic symptoms.
GalantaminePossible antagonism of action
GatifloxacinIncreased risk of cardiotoxicity and arrhythmias
GrepafloxacinIncreased risk of cardiotoxicity and arrhythmias
GuanethidinePromethazine may decrease the effect of guanethidine.
LevofloxacinIncreased risk of cardiotoxicity and arrhythmias
MazindolDecreased anorexic effect, may increase psychotic symptoms.
MethamphetamineDecreased anorexic effect, may increase pyschotic symptoms
MetrizamideIncreased risk of convulsions
PhendimetrazineDecreased anorexic effect, may increase pyschotic symptoms
PhenmetrazineDecreased anorexic effect, may increase pyschotic symptoms
PhentermineDecreased anorexic effect, may increase psychotic symptoms.
PhenylpropanolamineDecreased anorexic effect, may increase psychotic symptoms.
RivastigminePossible antagonism of action
SparfloxacinIncreased risk of cardiotoxicity and arrhythmias
TacrineThe therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Promethazine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
TerbinafineTerbinafine may reduce the metabolism and clearance of Promethazine. Consider alternate therapy or monitor for therapeutic/adverse effects of Promethazine if Terbinafine is initiated, discontinued or dose changed.
TerfenadineIncreased risk of cardiotoxicity and arrhythmias
ThiotepaThiotepa, a strong CYP2B6 inhibitor, may decrease the metabolism and clearance of Promethazine, a CYP2B6 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Promethazine if Thiotepa is initiated, discontinued or dose changed.
TramadolIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
TranylcypromineIncreased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
TrazodoneIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
TrimethobenzamideTrimethobenzamide and Promethazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
TrimipramineIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
TriprolidineTriprolidine and Promethazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
TrospiumTrospium and Promethazine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
VenlafaxineIncreased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
ZolmitriptanUse of two serotonin modulators, such as zolmitriptan and promethazine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Food Interactions
  • Take with food to reduce irritation. Avoid alcohol.

Targets

1. Histamine H1 receptor

Kind: protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Histamine H1 receptor P35367 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Suzuki A, Yasui-Furukori N, Mihara K, Kondo T, Furukori H, Inoue Y, Kaneko S, Otani K: Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Ther Drug Monit. 2003 Apr;25(2):192-6. Pubmed
  3. Smith BN, Armstrong WE: Histamine enhances the depolarizing afterpotential of immunohistochemically identified vasopressin neurons in the rat supraoptic nucleus via H1-receptor activation. Neuroscience. 1993 Apr;53(3):855-64. Pubmed
  4. Miller RA, Tu AT: Factors in snake venoms that increase capillary permeability. J Pharm Pharmacol. 1989 Nov;41(11):792-4. Pubmed
  5. Claro E, Arbones L, Garcia A, Picatoste F: Phosphoinositide hydrolysis mediated by histamine H1-receptors in rat brain cortex. Eur J Pharmacol. 1986 Apr 16;123(2):187-96. Pubmed
  6. Ikeda H, Kubo N, Nakamura A, Harada N, Minamino M, Yamashita T: Histamine-induced calcium released from cultured human mucosal microvascular endothelial cells from nasal inferior turbinate. Acta Otolaryngol. 1997 Nov;117(6):864-70. Pubmed
  7. Paton DM, Webster DR: Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985 Nov-Dec;10(6):477-97. Pubmed

2. D(2) dopamine receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
D(2) dopamine receptor P14416 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

3. Muscarinic acetylcholine receptor M1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M1 P11229 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

4. Muscarinic acetylcholine receptor M2

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M2 P08172 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

5. Muscarinic acetylcholine receptor M3

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M3 P20309 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

6. Muscarinic acetylcholine receptor M4

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M4 P08173 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

7. Muscarinic acetylcholine receptor M5

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M5 P08912 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

8. Alpha-1A adrenergic receptor

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: unknown

Components

Name UniProt ID Details
Alpha-1A adrenergic receptor P35348 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. 5-hydroxytryptamine receptor 2A

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 2A P28223 Details

References:

  1. Bileviciute I, Stenfors C, Theodorsson E, Lundeberg T: Unilateral injection of calcitonin gene-related peptide (CGRP) induces bilateral oedema formation and release of CGRP-like immunoreactivity in the rat hindpaw. Br J Pharmacol. 1998 Nov;125(6):1304-12. Pubmed
  2. Kelley BM, Porter JH: The role of muscarinic cholinergic receptors in the discriminative stimulus properties of clozapine in rats. Pharmacol Biochem Behav. 1997 Aug;57(4):707-19. Pubmed
  3. Hoenicke EM, Vanecek SA, Woods JH: The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. J Pharmacol Exp Ther. 1992 Oct;263(1):276-84. Pubmed
  4. Martinez F, Coleman JW: A comparison of the effects of chlorpromazine and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro. Int J Immunopharmacol. 1990;12(2):185-91. Pubmed
  5. Fiorella D, Rabin RA, Winter JC: The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56. Pubmed

10. Calmodulin

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Calmodulin P62158 Details

References:

  1. Cohen ME, Sharp GW, Donowitz M: Suggestion of a role for calmodulin and phosphorylation in regulation of rabbit ileal electrolyte transport: effects of promethazine. Am J Physiol. 1986 Nov;251(5 Pt 1):G710-7. Pubmed
  2. Scott JA, Khaw BA, Fallon JT, Locke E, Rabito CA, Peto CA, Homcy CJ: The effect of phenothiazines upon maintenance of membrane integrity in the cultured myocardial cell. J Mol Cell Cardiol. 1986 Dec;18(12):1243-54. Pubmed
  3. Lohr KM, Feix JB, Kurth C: Chlorpromazine inhibits neutrophil chemotaxis beyond the chemotactic receptor-ligand interaction. J Infect Dis. 1984 Nov;150(5):643-52. Pubmed
  4. DiPaola M, Keith CH, Feldman D, Tycko B, Maxfield FR: Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides. J Cell Physiol. 1984 Feb;118(2):193-202. Pubmed
  5. Luchowski EM, Yousif F, Triggle DJ, Maurer SC, Sarmiento JG, Janis RA: Effects of metal cations and calmodulin antagonists on [3H] nitrendipine binding in smooth and cardiac muscle. J Pharmacol Exp Ther. 1984 Sep;230(3):607-13. Pubmed

Enzymes

1. Cytochrome P450 2D6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  3. Platts SH, Shi SJ, Meck JV: Akathisia with combined use of midodrine and promethazine. JAMA. 2006 May 3;295(17):2000-1. Pubmed

2. Cytochrome P450 2B6

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2B6 P20813 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 2C9

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. Pubmed

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Drug created on June 13, 2005 07:24 / Updated on October 08, 2013 14:25