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Identification
NamePromethazine
Accession NumberDB01069  (APRD00601)
TypeSmall Molecule
GroupsApproved
Description

A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals. [PubChem]

Structure
Thumb
Synonyms
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
10-(2-Dimethylaminopropyl)phenothiazine
10-[2-(dimethylamino)Propyl]phenothiazine
N-(2'-dimethylamino-2'-Methyl)ethylphenothiazine
N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine
N,N,α-trimethyl-10H-phenothiazine-10-ethanamine
Proazamine
Prometazina
Promethazine
Promethazinum
External Identifiers
  • Lilly 1516
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Phenergan Injectable 25mg/mlsolution25 mgintramuscular; intravenousAventis Pharma Inc1949-12-312005-08-01Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Promethazine HClinjection, solution.5 mg/mLintravenousCantrell Drug Company2014-05-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine HClinjection, solution.625 mg/mLintravenousCantrell Drug Company2014-05-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine HClinjection, solution1 mg/mLintravenousCantrell Drug Company2014-05-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine HCl Inj 28.2mg/mlliquid28.2 mgintramuscular; intravenousDavid Bull Laboratories (Pty) Ltd.1985-12-311996-09-10Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Promethazine HCl Inj USPsolution25 mgintramuscular; intravenousAlveda Pharmaceuticals IncNot applicableNot applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Promethazine Hydrochloride Injection USPliquid25 mgintramuscular; intravenousSandoz Canada Incorporated1982-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Promethazine Hydrochloride Injection, USPsolution25 mgintramuscular; intravenousMylan Pharmaceuticals Ulc1994-12-312015-11-03Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Phenadozsuppository12.5 mg/1rectalPd Rx Pharmaceuticals, Inc.2003-06-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository12.5 mg/1rectalWatson Laboratories, Inc.2013-02-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository12.5 mg/1rectalPaddock Laboratories, Inc.2003-06-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository25 mg/1rectalPaddock Laboratories, Inc.2003-06-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository25 mg/1rectalActavis Pharma, Inc.2015-02-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository12.5 mg/1rectalActavis Pharma, Inc.2015-03-16Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository25 mg/1rectalWatson Laboratories, Inc.2013-04-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenadozsuppository25 mg/1rectalREMEDYREPACK INC.2013-05-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection, solution50 mg/mLintramuscularBaxter Healthcare Corporation2009-12-102015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenergansuppository50 mg/1rectalPrestium Pharma, Inc.2014-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection, solution25 mg/mLintramuscular; intravenousBaxter Healthcare Corporation2009-12-102015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenerganinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenergansuppository25 mg/1rectalPrestium Pharma, Inc.2014-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Phenergansuppository12.5 mg/1rectalPrestium Pharma, Inc.2014-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazinetablet12.5 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazineinjection25 mg/mLintramuscular; intravenousCardinal Health2002-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazineinjection50 mg/mLintramuscularPhysicians Total Care, Inc.2002-08-22Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine HCltablet25 mg/1oralCardinal Health2011-06-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralHi Tech Pharmacal Co., Inc.1998-09-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution50 mg/mLintramuscular; intravenousX Gen Pharmaceuticals, Inc.2015-01-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralSTAT Rx USA LLC1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralProficient Rx LP1982-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralDispensing Solutions, Inc.2006-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository12.5 mg/1rectalPhysicians Total Care, Inc.2003-05-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralMc Kesson Contract Packaging2011-09-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2008-02-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository12.5 mg/1rectalTaro Pharmaceuticals U.S.A., Inc.2015-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralRebel Distributors Corp2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralTYA Pharmaceuticals2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousDispensing Solutions Inc.2009-05-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution50 mg/mLintramuscular; intravenousCardinal Health2011-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2012-07-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralGolden State Medical Supply, Inc.2006-07-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralMajor Pharmaceuticals2015-03-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralAidarex Pharmaceuticals LLC2012-07-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralCadila Healthcare Limited2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralPreferred Pharmaceuticals, Inc.2013-04-24Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2008-02-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2005-09-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralQualitest Pharmaceuticals2006-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralKvk Tech, Inc.2014-07-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-05-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mg/1rectalPerrigo New York Inc2006-05-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralRebel Distributors Corp2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralReady Meds2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mg/1rectalDispensing Solutions Inc.2003-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousCardinal Health1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralPreferred Pharmaceuticals, Inc.2013-11-132015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralA S Medication Solutions Llc2006-04-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralClinical Solutions Wholesale1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralMajor Pharmaceuticals2011-07-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/301oralNorthwind Pharmaceuticals2014-05-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository50 mg/1rectalRenaissance Pharma, Inc.2014-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralCadila Healthcare Limited2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralPreferred Pharmaceuticals, Inc.2014-01-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralCardinal Health2012-08-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralPhysicians Total Care, Inc.1994-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralQualitest Pharmaceuticals2006-04-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralKvk Tech, Inc.2014-07-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository12.5 mg/1rectalPerrigo New York Inc2006-06-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralAidarex Pharmaceuticals LLC2012-07-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralReady Meds2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralAmerican Health Packaging2013-07-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousCardinal Health1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralMc Kesson Packaging Services Business Unit Of Mc Kesson Corporation2009-08-242015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralClinical Solutions Wholesale2009-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralMajor Pharmaceuticals2008-05-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/301oralNorthwind Pharmaceuticals2014-05-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mg/1rectalRenaissance Pharma, Inc.2014-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralRebel Distributors Corp1982-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralPreferred Pharmaceuticals, Inc.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2015-05-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralWatson Laboratories, Inc.1973-09-21Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralKvk Tech, Inc.2014-07-09Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-05-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralPd Rx Pharmaceuticals, Inc.2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralTris Pharma Inc2012-08-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralAmneal Pharmaceuticals2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralAmerican Health Packaging2013-07-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralCardinal Health2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralSun Pharmaceutical Industries, Inc.2009-03-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralLiberty Pharmaceuticals, Inc.2012-07-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralSandoz Inc1975-02-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralNorthwind Pharmaceuticals2014-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository12.5 mg/1rectalRenaissance Pharma, Inc.2014-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mg/1rectalRebel Distributors Corp2003-06-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralMc Kesson Packaging Services A Business Unit Of Mc Kesson Corporation1975-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2014-10-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralWatson Laboratories, Inc.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralBlenheim Pharmacal, Inc.2015-09-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/1intramuscularREMEDYREPACK INC.2013-04-11Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2012-08-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralAmneal Pharmaceuticals of New York, LLC2009-12-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesolution6.25 mg/5mLoralPreferred Pharmaceuticals, Inc.2013-09-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousCardinal Health2010-01-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralPhysicians Total Care, Inc.1995-08-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralSun Pharmaceutical Industries, Inc.2009-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousHospira, Inc.2009-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralSandoz Inc1975-12-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralNorthwind Pharmaceuticals2014-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralRebel Distributors Corp2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralbryant ranch prepack2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralBlue Point Laboratories2014-01-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralBlenheim Pharmacal, Inc.2010-05-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-05-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mg/1rectalPd Rx Pharmaceuticals, Inc.2006-05-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralHeritage Pharmaceuticals Inc.2013-02-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralAmneal Pharmaceuticals2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralZydus Pharmaceuticals (USA) Inc.2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousCardinal Health1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mg/1rectalPhysicians Total Care, Inc.2003-02-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralMorton Grove Pharmaceuticals, Inc.1982-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2008-05-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralMylan Institutional Inc.2007-02-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralRebel Distributors Corp1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralbryant ranch prepack1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralBlue Point Laboratories2014-01-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralDispensing Solutions, Inc.2006-04-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousBaxter Healthcare Corporation2009-12-102015-12-29Us 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralH.J. Harkins Company, Inc.2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralSun Pharmaceutical Industries, Inc.2009-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralBlenheim Pharmacal, Inc.2010-03-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-03-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralPd Rx Pharmaceuticals, Inc.2008-02-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralHeritage Pharmaceuticals Inc.2013-02-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralAmneal Pharmaceuticals2011-03-03Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralZydus Pharmaceuticals (USA) Inc.2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralCardinal Health2006-09-08Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralGolden State Medical Supply, Inc.2006-07-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection50 mg/mLintramuscularWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscularREMEDYREPACK INC.2014-02-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralLake Erie Medical DBA Quality Care Products LLC2010-10-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousX Gen Pharmaceuticals, Inc.2015-01-30Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralMed Vantx, Inc.2006-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralLife Line Home Care Services, Inc.2006-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2000-02-29Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralProficient Rx LP2009-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution50 mg/mLintramuscular; intravenousTeva Parenteral Medicines, Inc.2002-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralQualitest Pharmaceuticals2006-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralSTAT Rx USA LLC2006-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralUnit Dose Services2012-07-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralAtlantic Biologicals Corps1982-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralbryant ranch prepack2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralBlue Point Laboratories2014-01-13Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralPhysicians Total Care, Inc.2005-05-23Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralMc Kesson Contract Packaging2012-02-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution50 mg/mLintramuscularGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralSun Pharmaceutical Industries, Inc.2009-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralNcs Health Care Of Ky, Inc Dba Vangard Labs2009-01-27Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2008-02-12Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesuppository25 mg/1rectalTaro Pharmaceuticals U.S.A., Inc.2015-06-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralSTAT Rx USA LLC1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralHeritage Pharmaceuticals Inc.2013-02-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralTYA Pharmaceuticals1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralZydus Pharmaceuticals (USA) Inc.2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridesyrup6.25 mg/5mLoralCardinal Health1982-11-15Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralA S Medication Solutions Llc2012-07-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralGolden State Medical Supply, Inc.2006-07-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection25 mg/mLintramuscular; intravenousWest Ward Pharmaceutical Corp.1973-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralBlenheim Pharmacal, Inc.2011-08-25Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralREMEDYREPACK INC.2013-09-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousX Gen Pharmaceuticals, Inc.2011-05-02Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralCadila Healthcare Limited2005-12-14Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet12.5 mg/1oralPreferred Pharmaceuticals Inc.2015-08-19Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralPd Rx Pharmaceuticals, Inc.2008-05-20Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet50 mg/1oralPhysicians Total Care, Inc.1997-03-26Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralDIRECT RX2014-01-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochlorideinjection, solution25 mg/mLintramuscular; intravenousTeva Parenteral Medicines, Inc.2002-10-01Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralQualitest Pharmaceuticals2006-07-18Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethazine Hydrochloridetablet25 mg/1oralApotheca, Inc1999-06-10Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository50 mg/1rectalG&W Laboratories, Inc.1987-08-31Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mg/1rectalRebel Distributors Corp2002-02-05Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mg/1rectalREMEDYREPACK INC.2013-06-04Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository50 mg/1rectalPhysicians Total Care, Inc.1996-06-17Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mg/1rectalH.J. Harkins Company, Inc.2002-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository12.5 mg/1rectalG&W Laboratories, Inc.2004-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mg/1rectalPd Rx Pharmaceuticals, Inc.2002-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Promethegansuppository25 mg/1rectalG&W Laboratories, Inc.2002-02-28Not applicableUs 0a2ef1ad1c84951dc1392a8bbe1f3cb241c91ed59e44ad8268635315440d978c
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Histantil Tab 25mgtablet25 mgoralPharmascience Inc1983-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Histantil Tab 50mgtablet50 mgoralPharmascience Inc1983-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phenergan 50tablet50 mgoralColumbia Laboratories Canada Inc1996-12-312002-07-17Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phenergan Cream 2%cream2 %topicalRhone Poulenc Rorer Consumer Inc.1993-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phenergan Cream 2%cream2 %topicalColumbia Laboratories Canada Inc1996-07-302007-07-24Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phenergan Syrup 10mg/5mlsyrup10 mgoralRhone Poulenc Rorer Consumer Inc.1993-12-311996-09-09Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phenergan Tablet 10mgtablet10 mgoralRhone Poulenc Rorer Consumer Inc.1993-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phenergan Tablet 25mgtablet25 mgoralRhone Poulenc Rorer Consumer Inc.1993-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phenergan Tablet 25mgtablet25 mgoralNovartis Consumer Health Canada Inc.1996-12-311999-07-21Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
Phenergan Tablet 50mgtablet50 mgoralRhone Poulenc Rorer Consumer Inc.1992-12-311997-08-13Canada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
PMS-promethazine Syr 10mg/5mlsyrup10 mgoralPharmascience Inc1984-12-31Not applicableCanada 5f16b84899037e23705f146ff57e3794121879cb055f0954756d94bc690476b4
International Brands
NameCompany
AvomineNot Available
FarganNot Available
FarganesseNot Available
LergiganNot Available
ProthiazineNot Available
ReceptozineNot Available
RomerganNot Available
Brand mixtures
NameLabellerIngredients
Dextromethorphan Hydrobromide and Promethazine HydrochlorideAtlantic Biologicals Corps
Meperidine Hydrochloride and Promethazine HydrochlorideEci Pharmaceuticals Llc
Promatussin DM Adult Formula SyrWyeth Ayerst Canada Inc.
Promatussin DM Children FormulaWyeth Ltd.
Prometh With CodeineActavis Mid Atlantic LLC
Prometh With DextromethorphanActavis Mid Atlantic LLC
Promethazine DMQualitest Pharmaceuticals
Promethazine HCl, Phenylephrine HCl, Codeine PhosphateAmneal Pharmaceuticals of New York, LLC
Promethazine Hydrochloride and Codeine PhosphatePharmaceutical Associates, Inc.
Promethazine Hydrochloride and Dextomethorphan HydrobromideAmneal Pharmaceuticals
Promethazine Hydrochloride and Dextromethorphan HydrobromideRebel Distributors Corp
Promethazine Hydrochloride and Phenylephrine HydrochlorideActavis Mid Atlantic LLC
Promethazine Hydrochloride Phenylephrine Hydrochloride and Codeine Phosphatebryant ranch prepack
Promethazine Hydrochloride, Phenylephrine Hydrochloride, and Codeine PhosphateHi Tech Pharmacal Co., Inc.
Promethazine VcQualitest Pharmaceuticals
Promethazine Vc With CodeineActavis Mid Atlantic LLC
Promethazine With CodeineQualitest Pharmaceuticals
Promethazine With Codeine CoughMorton Grove Pharmaceuticals, Inc.
Salts
Name/CASStructureProperties
Promethazine hydrochloride
58-33-3
Thumb
  • InChI Key: XXPDBLUZJRXNNZ-UHFFFAOYNA-N
  • Monoisotopic Mass: 320.111397079
  • Average Mass: 320.88
DBSALT000427
Categories
UNIIFF28EJQ494
CAS number60-87-7
WeightAverage: 284.419
Monoisotopic: 284.13471934
Chemical FormulaC17H20N2S
InChI KeyInChIKey=PWWVAXIEGOYWEE-UHFFFAOYSA-N
InChI
InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
IUPAC Name
dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine
SMILES
CC(CN1C2=CC=CC=C2SC2=CC=CC=C12)N(C)C
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzothiazines
Sub ClassPhenothiazines
Direct ParentPhenothiazines
Alternative Parents
Substituents
  • Phenothiazine
  • Alkyldiarylamine
  • Diarylthioether
  • Benzenoid
  • Para-thiazine
  • Tertiary aliphatic amine
  • Tertiary amine
  • Azacycle
  • Thioether
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External DescriptorsNot Available
Pharmacology
IndicationFor the treatment of allergic disorders, and nausea/vomiting.
PharmacodynamicsPromethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Mechanism of actionLike other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone.
AbsorptionOn average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Volume of distributionNot Available
Protein binding93%
Metabolism

Hepatic

Route of eliminationPromethazine hydrochloride is metabolized in the liver, with the sulfoxides of promethazine and N-desmethylpromethazine being the predominant metabolites appearing in the urine.
Half life16-19 hours
ClearanceNot Available
ToxicitySymptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9832
Blood Brain Barrier+0.9855
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.8157
P-glycoprotein inhibitor IInhibitor0.8408
P-glycoprotein inhibitor IINon-inhibitor0.6473
Renal organic cation transporterInhibitor0.5156
CYP450 2C9 substrateNon-substrate0.7736
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.5338
CYP450 1A2 substrateInhibitor0.9107
CYP450 2C9 inhibitorNon-inhibitor0.9341
CYP450 2D6 inhibitorInhibitor0.8931
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8308
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.567
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.9088
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6959 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9786
hERG inhibition (predictor II)Inhibitor0.7661
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Tabletoral25 mg
Tabletoral50 mg
Capsuleoral
Suppositoryrectal12.5 mg/1
Suppositoryrectal25 mg/1
Creamtopical2 %
Solutionintramuscular; intravenous25 mg
Tabletoral10 mg
Syruporal10 mg
Injection, solutionintravenous.5 mg/mL
Injection, solutionintravenous.625 mg/mL
Injection, solutionintravenous1 mg/mL
Liquidintramuscular; intravenous28.2 mg
Injectionintramuscular25 mg/mL
Injectionintramuscular50 mg/mL
Injectionintramuscular; intravenous25 mg/mL
Injectionintramuscular; intravenous50 mg/mL
Injection, solutionintramuscular25 mg/1
Injection, solutionintramuscular50 mg/mL
Injection, solutionintramuscular; intravenous25 mg/mL
Injection, solutionintramuscular; intravenous50 mg/mL
Solutionoral6.25 mg/5mL
Syruporal6.25 mg/5mL
Tabletoral12.5 mg/1
Tabletoral25 mg/301
Tabletoral25 mg/1
Tabletoral50 mg/1
Syruporal
Solutionoral
Liquidintramuscular; intravenous25 mg
Liquidoral
Suppositoryrectal50 mg/1
Prices
Unit descriptionCostUnit
Promethegan 12 50 mg Suppository Box101.64USD box
Phenergan 12 50 mg Suppository Box80.16USD box
Phenergan 12 25 mg Suppository Box62.59USD box
Promethegan 12 25 mg Suppository Box62.27USD box
Promethazine HCl 12 50 mg Suppository Box60.94USD box
Phenergan 12 12.5 mg Suppository Box54.58USD box
Phenergan 25 mg suppository8.32USD suppository
Promethegan 50 mg suppository8.14USD suppository
Phenergan 12.5 mg suppository7.94USD suppository
Phenergan 50 mg suppository7.39USD suppository
Promethazine 50 mg suppository4.88USD suppository
Promethegan 25 mg suppository4.62USD suppository
Phenadoz 25 mg suppository4.45USD suppository
Promethazine 25 mg suppository4.32USD suppository
Promethegan 12.5 mg suppository4.02USD suppository
Promethazine HCl 12.5 mg Suppository4.0USD suppository
Phenadoz 12.5 mg suppository3.89USD suppository
Phenergan 25 mg/ml ampul3.84USD ml
Promethazine 12.5 mg suppository3.82USD suppository
Phenergan 50 mg/ml ampul3.68USD ml
Promethazine HCl 50 mg/ml Solution 1ml Ampule2.8USD ampule
Promethazine 50 mg/ml ampul2.25USD ml
Promethazine hcl powder2.14USD g
Promethazine 25 mg/ml ampul1.1USD ml
Promethazine 25 mg/ml1.06USD ml
Promethazine HCl 50 mg tablet0.81USD tablet
Promethazine 50 mg tablet0.78USD tablet
Promethazine HCl 25 mg tablet0.73USD tablet
Phenergan 25 mg tablet0.62USD tablet
Promethazine 25 mg tablet0.51USD tablet
Promethazine 12.5 mg tablet0.49USD tablet
Promethazine-DM 6.25-15 mg/5ml Syrup0.18USD ml
Promethazine HCl 6.25 mg/5ml Syrup0.11USD ml
Promethazine VC Plain 6.25-5 mg/5ml Syrup0.09USD ml
Promethazine-Codeine 6.25-10 mg/5ml Syrup0.06USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point60 °CPhysProp
boiling point190-192 °C at 3.00E+00 mm HgPhysProp
water solubility15.6 mg/L (at 24 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP4.81HANSCH,C ET AL. (1995)
logS-4.26ADME Research, USCD
pKa9.1SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.0245 mg/mLALOGPS
logP4.52ALOGPS
logP4.29ChemAxon
logS-4.1ALOGPS
pKa (Strongest Basic)9.05ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area6.48 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity88.5 m3·mol-1ChemAxon
Polarizability32.38 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (7.88 KB)
Spectra
Spectrum TypeDescriptionSplash Key
MSMass Spectrum (Electron Ionization)splash10-zb40000000-7167670dff3395a6ade2View in MoNA
References
Synthesis Reference

DrugSyn.org

US2530451
General References
  1. Peters RJ Jr, Kelder SH, Markham CM, Yacoubian GS Jr, Peters LA, Ellis A: Beliefs and social norms about codeine and promethazine hydrochloride cough syrup (CPHCS) onset and perceived addiction among urban Houstonian adolescents: an addiction trend in the city of lean. J Drug Educ. 2003;33(4):415-25. Pubmed
External Links
ATC CodesD04AA10R06AD02
AHFS Codes
  • 04:04.12
PDB EntriesNot Available
FDA labelDownload (93.4 KB)
MSDSDownload (74.8 KB)
Interactions
Drug Interactions
Drug
AbirateroneThe serum concentration of Promethazine can be increased when it is combined with Abiraterone.
AcepromazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Acepromazine.
AcetophenazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Acetophenazine.
AclidiniumAclidinium may increase the anticholinergic activities of Promethazine.
AmisulprideThe risk or severity of adverse effects can be increased when Promethazine is combined with Amisulpride.
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Promethazine.
AzelastinePromethazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Promethazine.
BenzquinamideThe risk or severity of adverse effects can be increased when Promethazine is combined with Benzquinamide.
Botulinum Toxin Type APromethazine may increase the anticholinergic activities of Botulinum Toxin Type A.
Botulinum Toxin Type BPromethazine may increase the anticholinergic activities of Botulinum Toxin Type B.
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
BuprenorphinePromethazine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
CarphenazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Carphenazine.
ChlormezanoneThe risk or severity of adverse effects can be increased when Promethazine is combined with Chlormezanone.
ChlorpromazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Chlorpromazine.
ChlorprothixeneThe risk or severity of adverse effects can be increased when Promethazine is combined with Chlorprothixene.
Cimetropium BromidePromethazine may increase the anticholinergic activities of Cimetropium Bromide.
CitalopramPromethazine may increase the QTc-prolonging activities of Citalopram.
ClozapineThe risk or severity of adverse effects can be increased when Promethazine is combined with Clozapine.
CobicistatThe serum concentration of Promethazine can be increased when it is combined with Cobicistat.
DabrafenibThe serum concentration of Promethazine can be decreased when it is combined with Dabrafenib.
DapoxetineThe risk or severity of adverse effects can be increased when Dapoxetine is combined with Promethazine.
DarunavirThe serum concentration of Promethazine can be increased when it is combined with Darunavir.
DofetilidePromethazine may increase the QTc-prolonging activities of Dofetilide.
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
EluxadolinePromethazine may increase the activities of Eluxadoline.
EpinephrinePromethazine may decrease the vasoconstricting activities of Epinephrine.
EthanolPromethazine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
FencamfamineThe risk or severity of adverse effects can be increased when Promethazine is combined with Fencamfamine.
FluoxetineThe metabolism of Promethazine can be decreased when combined with Fluoxetine.
FlupentixolThe risk or severity of adverse effects can be increased when Promethazine is combined with Flupentixol.
FluphenazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Fluphenazine.
FluspirileneThe risk or severity of adverse effects can be increased when Promethazine is combined with Fluspirilene.
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Promethazine.
Glucagon recombinantThe risk or severity of adverse effects can be increased when Promethazine is combined with Glucagon recombinant.
GoserelinPromethazine may increase the QTc-prolonging activities of Goserelin.
GranisetronGranisetron may increase the serotonergic activities of Promethazine.
HaloperidolThe risk or severity of adverse effects can be increased when Promethazine is combined with Haloperidol.
HydrocodonePromethazine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
Ipratropium bromideIpratropium bromide may increase the anticholinergic activities of Promethazine.
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Promethazine.
LeuprolidePromethazine may increase the QTc-prolonging activities of Leuprolide.
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Promethazine.
LoxapineThe risk or severity of adverse effects can be increased when Promethazine is combined with Loxapine.
LumacaftorThe serum concentration of Promethazine can be decreased when it is combined with Lumacaftor.
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
MesoridazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Mesoridazine.
MethotrimeprazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Methotrimeprazine.
MetoclopramideThe risk or severity of adverse effects can be increased when Metoclopramide is combined with Promethazine.
MetyrosineThe risk or severity of adverse effects can be increased when Metyrosine is combined with Promethazine.
MianserinMianserin may increase the anticholinergic activities of Promethazine.
MifepristoneMifepristone may increase the QTc-prolonging activities of Promethazine.
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
MirabegronThe risk or severity of adverse effects can be increased when Promethazine is combined with Mirabegron.
MolindoneThe risk or severity of adverse effects can be increased when Promethazine is combined with Molindone.
MorphineThe risk or severity of adverse effects can be increased when Promethazine is combined with Morphine.
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
NevirapineThe metabolism of Promethazine can be increased when combined with Nevirapine.
OlanzapineThe risk or severity of adverse effects can be increased when Promethazine is combined with Olanzapine.
OndansetronThe risk or severity of adverse effects can be increased when Promethazine is combined with Ondansetron.
OrphenadrinePromethazine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
PaliperidoneThe risk or severity of adverse effects can be increased when Promethazine is combined with Paliperidone.
PanobinostatThe serum concentration of Promethazine can be increased when it is combined with Panobinostat.
ParaldehydePromethazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Peginterferon alfa-2bThe serum concentration of Promethazine can be decreased when it is combined with Peginterferon alfa-2b.
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
PerphenazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Perphenazine.
PhenelzinePhenelzine may increase the orthostatic hypotensive activities of Promethazine.
PimozideThe risk or severity of adverse effects can be increased when Promethazine is combined with Pimozide.
PiperacetazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Piperacetazine.
Potassium ChloridePromethazine may increase the ulcerogenic activities of Potassium Chloride.
PramipexolePromethazine may increase the sedative activities of Pramipexole.
PramlintidePramlintide may increase the anticholinergic activities of Promethazine.
ProchlorperazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Prochlorperazine.
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Promethazine.
PromazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Promazine.
QuazepamThe serum concentration of Promethazine can be increased when it is combined with Quazepam.
QuetiapineThe risk or severity of adverse effects can be increased when Promethazine is combined with Quetiapine.
RacepinephrineThe therapeutic efficacy of Racepinephrine can be decreased when used in combination with Promethazine.
RamosetronPromethazine may increase the activities of Ramosetron.
RemoxiprideThe risk or severity of adverse effects can be increased when Promethazine is combined with Remoxipride.
ReserpineThe risk or severity of adverse effects can be increased when Promethazine is combined with Reserpine.
RisperidoneThe risk or severity of adverse effects can be increased when Promethazine is combined with Risperidone.
RitonavirThe metabolism of Promethazine can be decreased when combined with Ritonavir.
RopinirolePromethazine may increase the sedative activities of Ropinirole.
RotigotinePromethazine may increase the sedative activities of Rotigotine.
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Promethazine.
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Promethazine.
SertindoleThe risk or severity of adverse effects can be increased when Promethazine is combined with Sertindole.
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Promethazine.
SuvorexantPromethazine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TacrineThe therapeutic efficacy of Promethazine can be decreased when used in combination with Tacrine.
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
Tedizolid PhosphateTedizolid Phosphate may increase the serotonergic activities of Promethazine.
ThalidomidePromethazine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThioridazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Thioridazine.
ThiothixeneThe risk or severity of adverse effects can be increased when Promethazine is combined with Thiothixene.
TiclopidineThe metabolism of Promethazine can be decreased when combined with Ticlopidine.
TiotropiumPromethazine may increase the anticholinergic activities of Tiotropium.
TopiramateThe risk or severity of adverse effects can be increased when Promethazine is combined with Topiramate.
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Promethazine.
TranylcypromineTranylcypromine may increase the orthostatic hypotensive activities of Promethazine.
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Promethazine.
TrifluoperazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Trifluoperazine.
TriflupromazineThe risk or severity of adverse effects can be increased when Promethazine is combined with Triflupromazine.
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Promethazine.
ZiprasidoneThe risk or severity of adverse effects can be increased when Promethazine is combined with Ziprasidone.
ZolpidemPromethazine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZuclopenthixolThe risk or severity of adverse effects can be increased when Promethazine is combined with Zuclopenthixol.
Food Interactions
  • Take with food to reduce irritation. Avoid alcohol.

Targets

1. Histamine H1 receptor

Kind: Protein

Organism: Human

Pharmacological action: yes

Actions: antagonist

Components

Name UniProt ID Details
Histamine H1 receptor P35367 Details

References:

  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. Pubmed
  2. Suzuki A, Yasui-Furukori N, Mihara K, Kondo T, Furukori H, Inoue Y, Kaneko S, Otani K: Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Ther Drug Monit. 2003 Apr;25(2):192-6. Pubmed
  3. Smith BN, Armstrong WE: Histamine enhances the depolarizing afterpotential of immunohistochemically identified vasopressin neurons in the rat supraoptic nucleus via H1-receptor activation. Neuroscience. 1993 Apr;53(3):855-64. Pubmed
  4. Miller RA, Tu AT: Factors in snake venoms that increase capillary permeability. J Pharm Pharmacol. 1989 Nov;41(11):792-4. Pubmed
  5. Claro E, Arbones L, Garcia A, Picatoste F: Phosphoinositide hydrolysis mediated by histamine H1-receptors in rat brain cortex. Eur J Pharmacol. 1986 Apr 16;123(2):187-96. Pubmed
  6. Ikeda H, Kubo N, Nakamura A, Harada N, Minamino M, Yamashita T: Histamine-induced calcium released from cultured human mucosal microvascular endothelial cells from nasal inferior turbinate. Acta Otolaryngol. 1997 Nov;117(6):864-70. Pubmed
  7. Paton DM, Webster DR: Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines). Clin Pharmacokinet. 1985 Nov-Dec;10(6):477-97. Pubmed

2. D(2) dopamine receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
D(2) dopamine receptor P14416 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

3. Muscarinic acetylcholine receptor M1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M1 P11229 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

4. Muscarinic acetylcholine receptor M2

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M2 P08172 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

5. Muscarinic acetylcholine receptor M3

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M3 P20309 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

6. Muscarinic acetylcholine receptor M4

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M4 P08173 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

7. Muscarinic acetylcholine receptor M5

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
Muscarinic acetylcholine receptor M5 P08912 Details

References:

  1. Golembiewski JA, O’Brien D: A systematic approach to the management of postoperative nausea and vomiting. J Perianesth Nurs. 2002 Dec;17(6):364-76. Pubmed

8. Alpha-1A adrenergic receptor

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: unknown

Components

Name UniProt ID Details
Alpha-1A adrenergic receptor P35348 Details

References:

  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. 5-hydroxytryptamine receptor 2A

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: antagonist

Components

Name UniProt ID Details
5-hydroxytryptamine receptor 2A P28223 Details

References:

  1. Bileviciute I, Stenfors C, Theodorsson E, Lundeberg T: Unilateral injection of calcitonin gene-related peptide (CGRP) induces bilateral oedema formation and release of CGRP-like immunoreactivity in the rat hindpaw. Br J Pharmacol. 1998 Nov;125(6):1304-12. Pubmed
  2. Kelley BM, Porter JH: The role of muscarinic cholinergic receptors in the discriminative stimulus properties of clozapine in rats. Pharmacol Biochem Behav. 1997 Aug;57(4):707-19. Pubmed
  3. Hoenicke EM, Vanecek SA, Woods JH: The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors. J Pharmacol Exp Ther. 1992 Oct;263(1):276-84. Pubmed
  4. Martinez F, Coleman JW: A comparison of the effects of chlorpromazine and more selective histamine and 5-hydroxytryptamine antagonists on human IgG synthesis in vitro. Int J Immunopharmacol. 1990;12(2):185-91. Pubmed
  5. Fiorella D, Rabin RA, Winter JC: The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56. Pubmed

10. Calmodulin

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Calmodulin P62158 Details

References:

  1. Cohen ME, Sharp GW, Donowitz M: Suggestion of a role for calmodulin and phosphorylation in regulation of rabbit ileal electrolyte transport: effects of promethazine. Am J Physiol. 1986 Nov;251(5 Pt 1):G710-7. Pubmed
  2. Scott JA, Khaw BA, Fallon JT, Locke E, Rabito CA, Peto CA, Homcy CJ: The effect of phenothiazines upon maintenance of membrane integrity in the cultured myocardial cell. J Mol Cell Cardiol. 1986 Dec;18(12):1243-54. Pubmed
  3. Lohr KM, Feix JB, Kurth C: Chlorpromazine inhibits neutrophil chemotaxis beyond the chemotactic receptor-ligand interaction. J Infect Dis. 1984 Nov;150(5):643-52. Pubmed
  4. DiPaola M, Keith CH, Feldman D, Tycko B, Maxfield FR: Loss of alpha 2-macroglobulin and epidermal growth factor surface binding induced by phenothiazines and naphthalene sulfonamides. J Cell Physiol. 1984 Feb;118(2):193-202. Pubmed
  5. Luchowski EM, Yousif F, Triggle DJ, Maurer SC, Sarmiento JG, Janis RA: Effects of metal cations and calmodulin antagonists on [3H] nitrendipine binding in smooth and cardiac muscle. J Pharmacol Exp Ther. 1984 Sep;230(3):607-13. Pubmed

Enzymes

1. Cytochrome P450 2D6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2D6 P10635 Details

References:

  1. Flockhart DA. Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007). Accessed May 28, 2010.
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed
  3. Platts SH, Shi SJ, Meck JV: Akathisia with combined use of midodrine and promethazine. JAMA. 2006 May 3;295(17):2000-1. Pubmed

2. Cytochrome P450 2B6

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: substrate

Components

Name UniProt ID Details
Cytochrome P450 2B6 P20813 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

3. Cytochrome P450 2C9

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Cytochrome P450 2C9 P11712 Details

References:

  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. Pubmed

Transporters

1. Multidrug resistance protein 1

Kind: Protein

Organism: Human

Pharmacological action: unknown

Actions: inhibitor

Components

Name UniProt ID Details
Multidrug resistance protein 1 P08183 Details

References:

  1. Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. Pubmed

Comments
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Drug created on June 13, 2005 07:24 / Updated on October 08, 2013 14:25